aspartic acid has been researched along with Fibromyalgia in 8 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of memantine on metabolite levels in different areas of the brain and to determine whether changes in metabolite levels correlate with clinical variables in Fibromyalgia (FM) patients." | 9.19 | Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up. ( Andrés, E; Fayed, N; Garcia-Campayo, J; Herrera-Mercadal, P; López del Hoyo, Y; Magallon, R; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla-Guedea, M; Viguera, L, 2014) |
| "To evaluate the efficacy of memantine on metabolite levels in different areas of the brain and to determine whether changes in metabolite levels correlate with clinical variables in Fibromyalgia (FM) patients." | 5.19 | Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up. ( Andrés, E; Fayed, N; Garcia-Campayo, J; Herrera-Mercadal, P; López del Hoyo, Y; Magallon, R; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla-Guedea, M; Viguera, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, Y | 1 |
| Inokuchi, R | 1 |
| Suwa, H | 1 |
| Fayed, N | 2 |
| Olivan-Blázquez, B | 1 |
| Herrera-Mercadal, P | 1 |
| Puebla-Guedea, M | 1 |
| Pérez-Yus, MC | 1 |
| Andrés, E | 2 |
| López del Hoyo, Y | 1 |
| Magallon, R | 2 |
| Viguera, L | 1 |
| Garcia-Campayo, J | 2 |
| Foerster, BR | 1 |
| Nascimento, TD | 1 |
| DeBoer, M | 1 |
| Bender, MA | 1 |
| Rice, IC | 1 |
| Truong, DQ | 1 |
| Bikson, M | 1 |
| Clauw, DJ | 1 |
| Zubieta, JK | 1 |
| Harris, RE | 1 |
| DaSilva, AF | 1 |
| DeSantana, JM | 1 |
| Sluka, KA | 1 |
| Wood, PB | 1 |
| Ledbetter, CR | 1 |
| Glabus, MF | 1 |
| Broadwell, LK | 1 |
| Patterson, JC | 1 |
| Andrés-Bergareche, H | 1 |
| Luciano, JV | 1 |
| Beltrán, J | 1 |
| Feraco, P | 1 |
| Bacci, A | 1 |
| Pedrabissi, F | 2 |
| Passamonti, L | 1 |
| Zampogna, G | 1 |
| Malavolta, N | 1 |
| Leonardi, M | 1 |
| Emad, Y | 1 |
| Ragab, Y | 1 |
| Zeinhom, F | 1 |
| El-Khouly, G | 1 |
| Abou-Zeid, A | 1 |
| Rasker, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia[NCT01745003] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| The Chronic Pain Brain: Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing[NCT06143319] | 80 participants (Actual) | Observational | 2015-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspartic acid and Fibromyalgia
| Article | Year |
|---|---|
Reduced N-acetylaspartate in the hippocampus in patients with fibromyalgia: a meta-analysis.
Topics: Adult; Aspartic Acid; Databases, Factual; Fibromyalgia; Hippocampus; Humans; Magnetic Resonance Spec | 2013 |
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain.
Topics: Amides; Anesthetics, Local; Aspartic Acid; Chronic Disease; Cyclic AMP; Fatigue; Fibromyalgia; Gluta | 2008 |
3 trials available for aspartic acid and Fibromyalgia
| Article | Year |
|---|---|
Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up.
Topics: Adult; Aspartic Acid; Brain; Creatine; Dopamine Agents; Double-Blind Method; Female; Fibromyalgia; F | 2014 |
Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia.
Topics: Adult; Aspartic Acid; Brain; Female; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine | 2015 |
Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Chronic Pain; Creatinine; Dipeptides; Female; Fibromyalgia; Glutamic | 2011 |
3 other studies available for aspartic acid and Fibromyalgia
| Article | Year |
|---|---|
Hippocampal metabolite abnormalities in fibromyalgia: correlation with clinical features.
Topics: Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Fibromyalgia; Hippocampus; Humans; Magnetic | 2009 |
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; | 2010 |
Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Female; Fibromyalgia; | 2008 |