aspartic acid has been researched along with Epilepsy in 129 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Adenosine and adenosine analogues have potent anticonvulsant effects on various seizure models, including kindling, an animal model of temporal lobe epilepsy." | 7.69 | Adenosine A1 receptors in the rat brain in the kindling model of epilepsy. ( Beani, L; Bianchi, C; Borea, PA; Muzzolini, A; Simonato, M; Varani, K, 1994) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 7.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Metabolite maps of N-acetyl aspartate, choline and creatine were generated using (1)H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy." | 3.76 | Grid-free interactive and automated data processing for MR chemical shift imaging data. ( Confort-Gouny, S; Cozzone, PJ; Guye, M; Kober, F; Le Fur, Y; Nicoli, F, 2010) |
| " Using in vitro brain slices, we investigated the effects of uptake inhibition on two types of epileptiform activity, bicuculline-induced paroxysmal activity, and epileptiform responses in the freeze-lesion epilepsy model." | 3.73 | Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibition. ( Campbell, S; Hablitz, JJ, 2005) |
| "Compared with normal gray matter, hypothalamic hamartomas were hyperintense on T2-weighted images (93%), hypointense on T1-weighted images (74%), and had reduced N-acetylaspartate and increased myoinositol content shown by MR spectroscopy." | 3.72 | MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. ( Berkovic, SF; Coleman, LT; Freeman, JL; Harvey, AS; Jackson, GD; Kean, MJ; Rosenfeld, JV; Wellard, RM, 2004) |
| "Adenosine and adenosine analogues have potent anticonvulsant effects on various seizure models, including kindling, an animal model of temporal lobe epilepsy." | 3.69 | Adenosine A1 receptors in the rat brain in the kindling model of epilepsy. ( Beani, L; Bianchi, C; Borea, PA; Muzzolini, A; Simonato, M; Varani, K, 1994) |
| "The effects of ketamine and (+)cyclazocine on three in vitro models of epilepsy: the "Mg2+ free", the 4-aminopyridine (4-AP) and, for comparison, the penicillin model were studied." | 3.67 | Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats. ( de Carolis, AS; Frank, C; Sagratella, S, 1987) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 3.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Epilepsy is too complex to be considered as a disease; it is more of a syndrome, characterized by seizures, which can be caused by a diverse array of afflictions." | 2.55 | Control of seizures by ketogenic diet-induced modulation of metabolic pathways. ( Akabani, G; Aramayo, R; Clanton, RM; Wu, G, 2017) |
| "Patients with schizophrenia have a two- to three-fold increased risk of premature death as compared to patients without this disease." | 2.46 | Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia. ( Arida, RM; Cavalheiro, EA; Cysneiros, RM; Gattaz, WF; Schmitt, A; Scorza, FA, 2010) |
| "Furthermore, Aβ42, implicated in Alzheimer's disease, undergoes β-sheet to α-helix transition in presence of PIMT." | 1.56 | The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase. ( Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S, 2020) |
| "Semiology, seizure frequency, and therapy were assessed for all patients." | 1.46 | Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism. ( Bisulli, F; Ferri, L; Gramegna, LL; Licchetta, L; Lodi, R; Naldi, I; Rizzo, G; Testa, C; Tinuper, P; Tonon, C, 2017) |
| "Twenty-seven patients with migraine (8 with aura and 19 without aura) and 19 matched healthy controls were included in the study." | 1.39 | Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state. ( Alvarez-Linera, J; González de la Aleja, J; Hernández-Gallego, J; Hernández-Tamames, JA; Martínez-Salio, A; Mato-Abad, V; Molina, JA; Ramos, A, 2013) |
| "We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy." | 1.38 | Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012) |
| "Intracranial arachnoid cysts (ACs) are usually asymptomatic, benign developmental anomalies." | 1.35 | Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients. ( Ozcan, C; Ozisik, HI; Sarac, K, 2008) |
| "These data argue that within the seizure onset zone, the tight correlation between total power and NAA/Cr suggests that total electrical output is powered by available mitochondrial function." | 1.35 | Intracranial EEG power and metabolism in human epilepsy. ( Hetherington, HP; Pan, JW; Spencer, DD; Spencer, SS; Zaveri, HP, 2009) |
| "A 9-year-old girl with akinetic-rigid parkinsonism with tremor is described." | 1.33 | Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. ( Cantú-Martínez, L; Flores, Lde L; González, HC; Martínez, HR; Onofre-Castillo, J; Villarreal, HJ, 2006) |
| "An association between complex febrile convulsions and the development of hippocampal atrophy, which is characterized by neuron loss and gliosis, has been suggested but is still controversial." | 1.30 | Proton spectroscopy in children with epilepsy and febrile convulsions. ( Holopainen, IE; Komu, ME; Lundbom, NM; Manner, TE; Sillanpää, ML; Sonninen, PH; Valtonen, ME, 1998) |
| "Dexmedetomidine and the lower dose of atipamezole (0." | 1.29 | Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. ( Haapalinna, A; Halonen, T; Riekkinen, P; Valtonen, P, 1995) |
| " Both the dose-response relationship and the time course of the suppression of tonic seizures by topiramate were similar to the attenuation of glutamate level in SER." | 1.29 | Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER). ( Ishihara, K; Ishii, A; Kanda, T; Kurokawa, M; Kuwana, Y; Nakamura, J; Sasa, M; Serikawa, T; Tamura, S; Yamada, J, 1996) |
| "Recently epilepsy is analysed on terms of two different conditions, seizure susceptibility and seizure induction." | 1.28 | [Changes in content of excitatory amino acids in the brain and cerebrospinal fluid]. ( Eguchi, T; Enoki, Y; Hirabayashi, H; Nakase, H; Sakaki, T; Tada, T, 1990) |
| "Patients with partial epilepsy had a pattern of amino acids in CSF similar to that in patients with primary generalized seizures." | 1.28 | Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients. ( Halonen, T; Hartikainen, P; Kutvonen, R; Matilainen, R; Pitkänen, A; Riekkinen, P, 1989) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| " A dose-response relation for NMDA activation indicated that bath application of 1 and 5 microM NMDA had little or no effect on the response to a paired stimulus pulse (triggered response) and did not induce spontaneous bursting." | 1.27 | The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. ( Anderson, WW; Swartzwelder, HS; Wilson, WA, 1987) |
| "L-Allylglycine treatment led to a substantial decrease in the concentration of detectable GABA-immunoreactive bouton-like dots in the stratum oriens, radiatum and lacunosum-moleculare and in the deep hilar region, but did not produce statistically significant changes in this parameter in the outer and intermediate zones of the dentate molecular layer." | 1.27 | Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate. ( Meldrum, BS; Ottersen, OP; Storm-Mathisen, J; Swan, JH, 1987) |
| " On the other hand, although GLU and ASP themselves have minimal neurotoxic action, a relatively higher dosage than that of their analogues is needed to produce epileptic seizures." | 1.27 | [Epileptic seizure model utilizing additive effects of excitatory amino acids]. ( Kumashiro, H; Mori, N; Sato, T, 1988) |
| "Reversible encephalopathy was observed in 6 (7." | 1.26 | Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate. ( Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (31.01) | 18.7374 |
| 1990's | 28 (21.71) | 18.2507 |
| 2000's | 38 (29.46) | 29.6817 |
| 2010's | 22 (17.05) | 24.3611 |
| 2020's | 1 (0.78) | 2.80 |
| Authors | Studies |
|---|---|
| Chatterjee, T | 1 |
| Das, G | 1 |
| Chatterjee, BK | 1 |
| Dhar, J | 1 |
| Ghosh, S | 1 |
| Chakrabarti, P | 1 |
| Naldi, I | 1 |
| Bisulli, F | 1 |
| Testa, C | 1 |
| Rizzo, G | 1 |
| Ferri, L | 1 |
| Gramegna, LL | 1 |
| Licchetta, L | 1 |
| Lodi, R | 1 |
| Tonon, C | 1 |
| Tinuper, P | 1 |
| Barta, H | 1 |
| Jermendy, A | 1 |
| Kolossvary, M | 1 |
| Kozak, LR | 1 |
| Lakatos, A | 1 |
| Meder, U | 1 |
| Szabo, M | 1 |
| Rudas, G | 1 |
| BoAli, A | 1 |
| Tlili-Graiess, K | 1 |
| AlHashem, A | 1 |
| AlShahwan, S | 1 |
| Zuccoli, G | 1 |
| Tabarki, B | 1 |
| Meller, S | 1 |
| Brandt, C | 1 |
| Theilmann, W | 1 |
| Klein, J | 1 |
| Löscher, W | 2 |
| Jones, JM | 1 |
| Meisler, MH | 1 |
| Tschampa, HJ | 1 |
| Urbach, H | 1 |
| Träber, F | 1 |
| Sprinkart, AM | 1 |
| Greschus, S | 1 |
| Malter, MP | 1 |
| Surges, R | 1 |
| Gieseke, J | 1 |
| Block, W | 1 |
| Barros-Barbosa, AR | 1 |
| Fonseca, AL | 1 |
| Guerra-Gomes, S | 1 |
| Ferreirinha, F | 1 |
| Santos, A | 1 |
| Rangel, R | 1 |
| Lobo, MG | 1 |
| Correia-de-Sá, P | 1 |
| Cordeiro, JM | 1 |
| Juhász, C | 1 |
| Hu, J | 1 |
| Xuan, Y | 1 |
| Chugani, HT | 1 |
| Clanton, RM | 1 |
| Wu, G | 1 |
| Akabani, G | 1 |
| Aramayo, R | 1 |
| Liu, H | 1 |
| Fang, F | 1 |
| Zhu, H | 1 |
| Xia, SA | 1 |
| Han, D | 1 |
| Hu, L | 1 |
| Lei, H | 1 |
| Liu, M | 1 |
| Ozisik, HI | 1 |
| Sarac, K | 1 |
| Ozcan, C | 1 |
| Radwan, NM | 1 |
| El Hay Ahmed, NA | 1 |
| Ibrahim, KM | 1 |
| Khedr, ME | 1 |
| Aziz, MA | 1 |
| Khadrawy, YA | 1 |
| Pinheiro, GM | 1 |
| Basso, EA | 1 |
| Fiorin, BC | 1 |
| Cendes, F | 2 |
| Rittner, R | 1 |
| Oliveira, AN | 1 |
| Höehr, NF | 1 |
| Wibom, R | 1 |
| Lasorsa, FM | 1 |
| Töhönen, V | 1 |
| Barbaro, M | 1 |
| Sterky, FH | 1 |
| Kucinski, T | 1 |
| Naess, K | 1 |
| Jonsson, M | 1 |
| Pierri, CL | 1 |
| Palmieri, F | 1 |
| Wedell, A | 1 |
| Pan, JW | 2 |
| Zaveri, HP | 1 |
| Spencer, DD | 2 |
| Hetherington, HP | 2 |
| Spencer, SS | 1 |
| Nyitrai, G | 1 |
| Lasztóczi, B | 1 |
| Kardos, J | 1 |
| Serrano Castro, PJ | 1 |
| Naranjo Fernandez, C | 1 |
| Quiroga Subirana, P | 1 |
| Payan Ortiz, M | 1 |
| Le Fur, Y | 2 |
| Nicoli, F | 1 |
| Guye, M | 1 |
| Confort-Gouny, S | 2 |
| Cozzone, PJ | 2 |
| Kober, F | 1 |
| Scorza, FA | 1 |
| Schmitt, A | 1 |
| Cysneiros, RM | 1 |
| Arida, RM | 1 |
| Cavalheiro, EA | 2 |
| Gattaz, WF | 1 |
| Shao, XL | 1 |
| Zhou, ZS | 1 |
| Hong, W | 1 |
| Xie, W | 1 |
| Yu, Y | 1 |
| Zhao, Y | 1 |
| Striano, P | 1 |
| Morana, G | 1 |
| Pezzella, M | 1 |
| Bellini, T | 1 |
| Rossi, A | 1 |
| Lee, EM | 1 |
| Park, GY | 1 |
| Im, KC | 1 |
| Kim, ST | 1 |
| Woo, CW | 1 |
| Chung, JH | 1 |
| Kim, KS | 1 |
| Kim, JS | 1 |
| Shon, YM | 1 |
| Kim, YI | 1 |
| Kang, JK | 1 |
| Dogan, M | 1 |
| Dogan, DG | 1 |
| Kahraman, AS | 1 |
| Ozcan, O | 1 |
| Yakinci, C | 1 |
| Alkan, A | 1 |
| Filatova, YB | 1 |
| Voronina, TA | 1 |
| Klodt, PM | 1 |
| Kudrin, VS | 2 |
| Nerobkova, LN | 1 |
| Rider, FK | 1 |
| Avakyan, GN | 1 |
| Udow, S | 1 |
| Bunge, M | 1 |
| Ryner, L | 1 |
| Mhanni, AA | 1 |
| Salman, MS | 1 |
| Deng, Y | 1 |
| Wang, M | 1 |
| Wang, W | 1 |
| Ma, C | 1 |
| He, N | 1 |
| González de la Aleja, J | 1 |
| Ramos, A | 1 |
| Mato-Abad, V | 1 |
| Martínez-Salio, A | 1 |
| Hernández-Tamames, JA | 1 |
| Molina, JA | 1 |
| Hernández-Gallego, J | 1 |
| Alvarez-Linera, J | 1 |
| Ziyeh, S | 1 |
| Thiel, T | 1 |
| Spreer, J | 1 |
| Klisch, J | 1 |
| Schumacher, M | 1 |
| Gillessen, T | 1 |
| Budd, SL | 1 |
| Lipton, SA | 1 |
| Yan, HD | 1 |
| Ishihara, K | 3 |
| Serikawa, T | 3 |
| Sasa, M | 4 |
| Wieser, HG | 1 |
| Rudolph, U | 1 |
| Blau, N | 1 |
| Boison, D | 1 |
| Imhof, HG | 1 |
| Bernays, R | 1 |
| Yonekawa, Y | 1 |
| Freeman, JL | 1 |
| Coleman, LT | 1 |
| Wellard, RM | 2 |
| Kean, MJ | 1 |
| Rosenfeld, JV | 1 |
| Jackson, GD | 2 |
| Berkovic, SF | 1 |
| Harvey, AS | 1 |
| Kim, JH | 1 |
| Campbell, SL | 1 |
| Hablitz, JJ | 2 |
| Chen, L | 1 |
| Liao, WP | 1 |
| Sorenson, J | 1 |
| Santhanam, AV | 1 |
| Smith, LA | 1 |
| Akiyama, M | 1 |
| Sessa, WC | 1 |
| Katusic, ZS | 1 |
| Mueller, SG | 3 |
| D Laxer, K | 1 |
| Barakos, JA | 2 |
| Cashdollar, N | 3 |
| Flenniken, DL | 2 |
| Vermathen, P | 2 |
| Matson, GB | 2 |
| Weiner, MW | 4 |
| Chernov, MF | 1 |
| Kubo, O | 1 |
| Hayashi, M | 1 |
| Izawa, M | 1 |
| Maruyama, T | 1 |
| Usukura, M | 1 |
| Ono, Y | 1 |
| Hori, T | 1 |
| Takakura, K | 1 |
| Briellmann, RS | 1 |
| Laxer, KD | 3 |
| Campbell, S | 1 |
| Kang, N | 1 |
| Xu, J | 1 |
| Xu, Q | 1 |
| Nedergaard, M | 1 |
| Kang, J | 1 |
| Lopez, RC | 1 |
| Schuff, N | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Martínez, HR | 1 |
| Cantú-Martínez, L | 1 |
| González, HC | 1 |
| Flores, Lde L | 1 |
| Villarreal, HJ | 1 |
| Onofre-Castillo, J | 1 |
| Yapici, Z | 1 |
| Dörtcan, N | 1 |
| Baykan, BB | 1 |
| Okan, F | 1 |
| Dinçer, A | 1 |
| Baykal, C | 1 |
| Eraksoy, M | 1 |
| Roach, S | 1 |
| Hiremath, GK | 1 |
| Najm, IM | 1 |
| Gundersen, V | 1 |
| Chapman, A | 2 |
| Keane, PE | 1 |
| Meldrum, BS | 5 |
| Simiand, J | 1 |
| Vernieres, JC | 1 |
| Craig, CR | 2 |
| Engelsen, B | 1 |
| Elsayed, S | 1 |
| van Gelder, NM | 4 |
| Janjua, NA | 2 |
| Metrakos, K | 1 |
| MacGibbon, B | 1 |
| Metrakos, JD | 1 |
| Wiley, RG | 1 |
| Gralla, RJ | 1 |
| Casper, ES | 1 |
| Kemeny, N | 1 |
| Coutinho-Netto, J | 1 |
| Abdul-Ghani, AS | 1 |
| Collins, JF | 1 |
| Bradford, HF | 1 |
| Simonato, M | 1 |
| Varani, K | 1 |
| Muzzolini, A | 1 |
| Bianchi, C | 1 |
| Beani, L | 1 |
| Borea, PA | 1 |
| Flavin, HJ | 2 |
| Seyfried, TN | 2 |
| Monaco, F | 1 |
| Gianelli, M | 2 |
| Schiavella, MP | 1 |
| Naldi, P | 1 |
| Cantello, R | 2 |
| Torta, R | 1 |
| Verzé, L | 1 |
| Mutani, R | 2 |
| Breiter, SN | 1 |
| Arroyo, S | 1 |
| Mathews, VP | 1 |
| Lesser, RP | 1 |
| Bryan, RN | 1 |
| Barker, PB | 1 |
| Valtonen, P | 1 |
| Haapalinna, A | 1 |
| Riekkinen, P | 2 |
| Halonen, T | 2 |
| Duncan, JS | 3 |
| Gadian, DG | 1 |
| Kanda, T | 1 |
| Kurokawa, M | 1 |
| Tamura, S | 1 |
| Nakamura, J | 1 |
| Ishii, A | 1 |
| Kuwana, Y | 1 |
| Yamada, J | 1 |
| Chapman, AG | 1 |
| Elwes, RD | 1 |
| Millan, MH | 1 |
| Polkey, CE | 1 |
| Yamamoto, A | 1 |
| Takagi, H | 1 |
| Kitamura, D | 1 |
| Tatsuoka, H | 1 |
| Nakano, H | 1 |
| Kawano, H | 1 |
| Kuroyanagi, H | 2 |
| Yahagi, Y | 1 |
| Kobayashi, S | 1 |
| Koizumi, K | 1 |
| Sakai, T | 1 |
| Saito, K | 1 |
| Chiba, T | 1 |
| Kawamura, K | 1 |
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| Watanabe, T | 1 |
| Mori, H | 1 |
| Shirasawa, T | 2 |
| Holopainen, IE | 1 |
| Valtonen, ME | 1 |
| Komu, ME | 1 |
| Sonninen, PH | 1 |
| Manner, TE | 1 |
| Lundbom, NM | 1 |
| Sillanpää, ML | 1 |
| Simantov, R | 1 |
| Crispino, M | 1 |
| Hoe, W | 1 |
| Broutman, G | 1 |
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| Rothstein, JD | 1 |
| Baudry, M | 1 |
| Chugani, DC | 1 |
| Sundram, BS | 1 |
| Behen, M | 1 |
| Lee, ML | 1 |
| Moore, GJ | 1 |
| Aasly, J | 1 |
| Silfvenius, H | 1 |
| Aas, TC | 1 |
| Sonnewald, U | 1 |
| Olivecrona, M | 1 |
| Juul, R | 1 |
| White, LR | 1 |
| Omori, K | 1 |
| Inagaki, C | 1 |
| Ghijsen, WE | 1 |
| da Silva Aresta Belo, AI | 1 |
| Zuiderwijk, M | 1 |
| Lopez da Silva, FH | 1 |
| Akimitsu, T | 1 |
| Kurisu, K | 1 |
| Hanaya, R | 1 |
| Iida, K | 1 |
| Kiura, Y | 1 |
| Arita, K | 1 |
| Matsubayashi, H | 1 |
| Kitada, K | 1 |
| van der Knaap, MS | 1 |
| Verhoeven, NM | 1 |
| Maaswinkel-Mooij, P | 1 |
| Pouwels, PJ | 1 |
| Onkenhout, W | 1 |
| Peeters, EA | 1 |
| Stöckler-Ipsiroglu, S | 1 |
| Jakobs, C | 1 |
| Ranjeva, JP | 1 |
| McLean, MA | 2 |
| Woermann, FG | 2 |
| Barker, GJ | 2 |
| Mizuno, S | 1 |
| Takahashi, Y | 1 |
| Kato, Z | 1 |
| Goto, H | 1 |
| Kondo, N | 1 |
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| Bartlett, PA | 1 |
| Ronne Engström, E | 1 |
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| Flink, R | 1 |
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| Raevskiĭ, KS | 1 |
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| Pohler, G | 1 |
| Lodge, D | 2 |
| Psarropoulou, C | 1 |
| Haas, HL | 1 |
| Stasheff, SF | 1 |
| Anderson, WW | 2 |
| Clark, S | 1 |
| Wilson, WA | 2 |
| Porter, RJ | 1 |
| Gean, PW | 1 |
| Shinnick-Gallagher, P | 1 |
| Anderson, AC | 1 |
| Smith, CC | 1 |
| Bowen, DM | 1 |
| Francis, PT | 1 |
| Snowden, JS | 1 |
| Neary, D | 1 |
| Sloviter, RS | 2 |
| Dempster, DW | 1 |
| Allen, IC | 1 |
| Grieve, A | 1 |
| Griffiths, R | 1 |
| Swartzwelder, HS | 1 |
| Stone, TW | 1 |
| Connick, JH | 1 |
| Winn, P | 1 |
| Hastings, MH | 1 |
| English, M | 1 |
| Swan, JH | 1 |
| Ottersen, OP | 1 |
| Storm-Mathisen, J | 1 |
| Sagratella, S | 1 |
| Frank, C | 1 |
| de Carolis, AS | 1 |
| Sato, T | 1 |
| Mori, N | 1 |
| Kumashiro, H | 1 |
| Slevin, JT | 1 |
| Kasarskis, EJ | 1 |
| Vanaman, TC | 1 |
| Zurini, M | 1 |
| Nolting, B | 1 |
| Hönack, D | 1 |
| Araki, K | 1 |
| Harada, M | 1 |
| Ueda, Y | 1 |
| Takino, T | 1 |
| Kuriyama, K | 1 |
| McNamara, JO | 1 |
| Bonhaus, DW | 1 |
| Shin, C | 1 |
| Pumain, R | 1 |
| Louvel, J | 1 |
| Kurcewicz, I | 1 |
| Lehmann, A | 1 |
| Hagberg, H | 1 |
| Lazarewicz, JW | 1 |
| Jacobson, I | 1 |
| Hamberger, A | 1 |
| Heinemann, U | 1 |
| Turski, L | 1 |
| Calderazzo-Filho, LS | 1 |
| Bortolotto, ZA | 1 |
| Ikonomidou-Turski, C | 1 |
| Turski, WA | 1 |
| Hartman, ER | 1 |
| Rasmussen, T | 1 |
| Courtois, A | 1 |
| Koyama, I | 1 |
| Saradzhishvili, PM | 1 |
| Vetgoron, FG | 1 |
| Okudzhava, VM | 1 |
| Sprinkle, T | 1 |
| Greer, M | 1 |
| Williams, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001] | Phase 1 | 4 participants (Actual) | Interventional | 2006-02-28 | Terminated | ||
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for aspartic acid and Epilepsy
| Article | Year |
|---|---|
Control of seizures by ketogenic diet-induced modulation of metabolic pathways.
Topics: Amino Acids, Essential; Aspartic Acid; Demyelinating Diseases; Diet, Ketogenic; Epilepsy; Fatty Acid | 2017 |
Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia.
Topics: Antipsychotic Agents; Aspartic Acid; Death, Sudden, Cardiac; Epilepsy; Glutamine; Humans; Prefrontal | 2010 |
Excitatory amino acid neurotoxicity.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Calcium; Epilepsy; Glutamic Acid; Hum | 2002 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Magnetic resonance spectroscopy in animal models of epilepsy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Choline; Creatine; Disease Models, Animal; Epilepsy; | 2007 |
Co-localization of excitatory and inhibitory transmitters in the brain.
Topics: Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Mossy Fibers, Hippocampal; | 2008 |
Mechanism of anticonvulsant action of valproate.
Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life; | 1982 |
Magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Creatinine; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; gamm | 1996 |
Clinical applications of magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Brain Mapping; Epilepsy; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; Fron | 1997 |
Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy.
Topics: Animals; Aspartic Acid; Brain; Disease Progression; Epilepsy; Epilepsy, Tonic-Clonic; Mice; Mice, In | 1998 |
[Molecular mechanism underlying epileptic seizure: forwards development of novel drugs for untreatable epilepsy].
Topics: Amidohydrolases; Animals; Anticonvulsants; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cerulop | 1999 |
Magnetic resonance spectroscopy of brain in epilepsy.
Topics: Aspartic Acid; Brain; Brain Mapping; Child; Dominance, Cerebral; Energy Metabolism; Epilepsy; gamma- | 2000 |
Rational basis for the development of new antiepileptic drugs.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Electroencephalography; Epilepsy; Glutamates; Glutam | 1991 |
Excitatory amino acids in epilepsy and novel anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Glutamic Acid; Humans; Receptors, N-M | 1991 |
Excitatory amino acid transmitters in epilepsy.
Topics: Anticonvulsants; Aspartic Acid; Epilepsy; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans | 1991 |
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; | 1985 |
Endogenous excitotoxic agents.
Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Gluta | 1987 |
2 trials available for aspartic acid and Epilepsy
| Article | Year |
|---|---|
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy | 2001 |
109 other studies available for aspartic acid and Epilepsy
| Article | Year |
|---|---|
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothi | 2020 |
Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Epilepsy; Female; Gyrus Cinguli; Humans; Magne | 2017 |
Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.
Topics: Aspartic Acid; Brain; Creatine; Epilepsy; Female; Hearing Loss; Hospital Mortality; Humans; Hypother | 2018 |
Novel Homozygous Mutation of the AIMP1 Gene: A Milder Neuroimaging Phenotype With Preservation of the Deep White Matter.
Topics: Adolescent; Adult; Aspartic Acid; Child; Consanguinity; Cytokines; Developmental Disabilities; Epile | 2019 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
Topics: Animals; Asparagine; Aspartic Acid; Disease Models, Animal; Embryo, Mammalian; Endonucleases; Epilep | 2014 |
Proton magnetic resonance spectroscopy in focal cortical dysplasia at 3T.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Child, Preschool; Choline; Creatine; Drug Resistant E | 2015 |
Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Carbon Isotopes; Child; Disks Large Homolog 4 Protein; Epile | 2016 |
Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Epilepsy; Female; Fluorodeoxyglucose F18; F | 2016 |
Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Disease Models, Animal; Electric Stimulation; Electroencephal | 2008 |
Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients.
Topics: Adolescent; Adult; Arachnoid Cysts; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Creatine; E | 2008 |
Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.
Topics: Alanine Transaminase; Amino Acids; Analysis of Variance; Animals; Aspartate Aminotransferases; Aspar | 2009 |
A fast 1H NMR spectroscopy procedure for quantitative determination of N-acetylaspartate in urine samples.
Topics: Adult; Aspartic Acid; Epilepsy; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2009 |
AGC1 deficiency associated with global cerebral hypomyelination.
Topics: Amino Acid Transport Systems, Acidic; Antiporters; Aspartic Acid; Cerebrum; Child, Preschool; Epilep | 2009 |
Intracranial EEG power and metabolism in human epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Creatine; Electrodes, Implanted; Electroencephalography; En | 2009 |
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationsh | 2010 |
Vohwinkel Syndrome secondary to missense mutation D66H in GJB2 gene (connexin 26) can include epileptic manifestations.
Topics: Aspartic Acid; Connexin 26; Connexins; Epilepsy; Histidine; Humans; Keratoderma, Palmoplantar; Male; | 2010 |
Grid-free interactive and automated data processing for MR chemical shift imaging data.
Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Elect | 2010 |
[Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy].
Topics: Aspartic Acid; Child; Child, Preschool; Choline; Epilepsy; Female; Humans; Magnetic Resonance Imagin | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Rhombencephalosynapsis in a patient with mental retardation, epilepsy, and dysmorphisms.
Topics: Adolescent; Aspartic Acid; Body Dysmorphic Disorders; Creatine; Epilepsy; Humans; Intellectual Disab | 2011 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Adolescent; Anticonvulsants; Aspartic Acid; Biomarkers; Brain; Child; Creatinine; Disease Progressio | 2012 |
Changes in the levels of inhibitory and excitatory amino acids in the brain structures of female rats with cobalt epileptogenic focus during different phases of the estrous cycle.
Topics: Animals; Animals, Outbred Strains; Aspartic Acid; Cobalt; Epilepsy; Estrous Cycle; Excitatory Amino | 2011 |
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M | 2012 |
Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats.
Topics: Animals; Aspartic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kin | 2013 |
Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state.
Topics: Adult; Analysis of Variance; Aspartic Acid; Case-Control Studies; Epilepsy; Female; Glutamic Acid; G | 2013 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy | 2002 |
Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors.
Topics: Action Potentials; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; | 2003 |
Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures.
Topics: Adenosine; Adolescent; Adult; Anticonvulsants; Aspartic Acid; Brain; Child; Cysts; Electroencephalog | 2003 |
MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases.
Topics: Adolescent; Adult; Aspartic Acid; Cell Count; Cerebral Cortex; Child; Child, Preschool; Dominance, C | 2004 |
1H and 31P spectroscopic imaging of epilepsy: spectroscopic and histologic correlations.
Topics: Adult; Amygdala; Aspartic Acid; Brain; Choline; Creatine; Epilepsy; Epilepsy, Temporal Lobe; Female; | 2004 |
Glutamate transporters regulate excitability in local networks in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; | 2004 |
[Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii].
Topics: Acorus; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; H | 2004 |
Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries.
Topics: Adult; Aspartic Acid; Cerebral Arteries; Cyclic GMP; Endothelium, Vascular; Epilepsy; Female; Gene E | 2005 |
Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Electroencephalography; Epilepsi | 2004 |
Proton MRS of the peritumoral brain.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Edema; Brain Neoplasms; Epilepsy; Female; Huma | 2005 |
Metabolic characteristics of cortical malformations causing epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Epilepsy; Humans; Image Proces | 2005 |
Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibition.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; Cerebral Cortex; Disease Mode | 2005 |
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals | 2005 |
Spectroscopic evidence of hippocampal abnormalities in neocortical epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Epilepsy; Female; Functional Laterality; Hippoc | 2006 |
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.
Topics: Anticonvulsants; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Benzothiazoles; Carbamazepine; | 2006 |
Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy.
Topics: Adolescent; Aspartic Acid; Child; Child, Preschool; Creatine; Epilepsy; Female; Humans; Infant; Magn | 2007 |
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Brain; Choline O-Acetyltransferase; Dis | 1984 |
Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: an effect of medication?
Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Drug Therapy, Combination; Epilepsie | 1984 |
Plasma amino acids in 3/sec spike-wave epilepsy.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aspartic Acid; Child; Child, Preschool; Epilepsy; Female; G | 1980 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models | 1982 |
Is glutamate a trigger factor in epileptic hyperactivity?
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Epilep | 1981 |
Adenosine A1 receptors in the rat brain in the kindling model of epilepsy.
Topics: Adenosine; Animals; Aspartic Acid; Brain; Epilepsy; In Vitro Techniques; Kindling, Neurologic; Male; | 1994 |
Enhanced aspartate release related to epilepsy in (EL) mice.
Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca | 1994 |
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taur | 1994 |
Proton MR spectroscopy in patients with seizure disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Cortex; Child; Child, Preschool; Choline; Creatine | 1994 |
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1995 |
N-acetylaspartate and epilepsy.
Topics: Adult; Aspartic Acid; Brain Damage, Chronic; Brain Mapping; Child; Choline; Creatine; Dominance, Cer | 1995 |
Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER).
Topics: Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Excitatory Amino Acids; Female; Fructose; Glutami | 1996 |
Role of glutamate and aspartate in epileptogenesis; contribution of microdialysis studies in animal and man.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Electroencephalography; Epilepsies, Partial; Epilepsy; | 1996 |
Proton spectroscopy in children with epilepsy and febrile convulsions.
Topics: Aspartic Acid; Child; Child, Preschool; Choline; Electroencephalography; Epilepsy; Hippocampus; Huma | 1998 |
Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Brain Chemistry; Carrier Proteins; | 1999 |
Evidence of altered energy metabolism in autistic children.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Brain; Cerebellum; Child; Child, Preschool; Energy Met | 1999 |
Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Biopsy; Brain; Brain Chemistry; Child; Epilepsy; Female; gamma-Ami | 1999 |
Compensatory change in EAAC1 glutamate transporter in rat hippocampus CA1 region during kindling epileptogenesis.
Topics: Adaptation, Physiological; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cas | 1999 |
Epileptic seizures induced by N-acetyl-L-aspartate in rats: in vivo and in vitro studies.
Topics: Animals; Aspartic Acid; Electroencephalography; Epilepsy; Frontal Lobe; Hippocampus; Male; Rats; Rat | 2000 |
Mental retardation and behavioral problems as presenting signs of a creatine synthesis defect.
Topics: Aspartic Acid; Body Fluids; Brain Diseases, Metabolic; Child, Preschool; Creatine; Diagnosis, Differ | 2000 |
Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
Topics: Adult; Age Factors; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Disease | 2000 |
Proton MRS: lactate.
Topics: Animals; Aspartic Acid; Epilepsy; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Protons | 2000 |
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Craniocerebral Trauma; Electroencephalo | 2001 |
Neurologic course of congenital disorders of glycosylation.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorde | 2001 |
[Features of neurotransmitter pool in cerebrospinal fluid of patients with epilepsy].
Topics: Adult; Aspartic Acid; Brain; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Huma | 2001 |
Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice.
Topics: Aging; Animals; Aspartic Acid; Cognition; Cognition Disorders; Epilepsy; Isomerism; Long-Term Potent | 2001 |
Biochemical observations following administration of taurine to patients with epilepsy.
Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool | 1975 |
Kindling seizure induction and excitatory amino acid.
Topics: Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Epilepsy; Glutamates; Glutamic Acid; Kind | 1992 |
Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; In Vitro Techniques; Mice; Mice, Ne | 1992 |
Enhanced aspartate release from hippocampal slices of epileptic (El) mice.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; M | 1991 |
Sequential changes in content of excitatory amino acids in the focus of epilepsy in seizure induction.
Topics: Amygdala; Animals; Aspartic Acid; Cats; Chromatography, High Pressure Liquid; Electroencephalography | 1991 |
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D | 1990 |
Increased aspartic acid release from the iron-induced epileptogenic focus.
Topics: Acute Disease; Animals; Aspartic Acid; Chronic Disease; Epilepsy; Glutamates; Glutamic Acid; Iron; M | 1990 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dos | 1990 |
[Changes in content of excitatory amino acids in the brain and cerebrospinal fluid].
Topics: Animals; Aspartic Acid; Brain; Cats; Disease Susceptibility; Epilepsy; Glutamates; Kindling, Neurolo | 1990 |
Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients.
Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Carnosine; Dipeptides; Epilepsies, Partial; Epilepsy; | 1989 |
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.
Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Dextromethorphan; Dose-Response Relationship, Dr | 1989 |
Action of anticonvulsants on hippocampal slices in Mg-free medium.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Ele | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; | 1989 |
Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techniques; Kindling, Neurologic | 1989 |
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; | 1985 |
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 1985 |
Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Corpus Striatum; Epilepsy; gamma-Aminobutyric A | 1986 |
On the role of seizure activity and endogenous excitatory amino acids in mediating seizure-associated hippocampal damage.
Topics: Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Survival; Dendrites; Epi | 1986 |
The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; Epilep | 1987 |
Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate.
Topics: Allylglycine; Animals; Aspartic Acid; Bicuculline; Cerebellum; Epilepsy; Evoked Potentials; gamma-Am | 1987 |
Neurotransmitter amino acids in epilepsy.
Topics: Amino Acids; Aspartic Acid; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutami | 1987 |
Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cyclazocine; E | 1987 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro | 1987 |
[Epileptic seizure model utilizing additive effects of excitatory amino acids].
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Drug Synergism; Electroencephalography; Epilepsy; Glu | 1988 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Aci | 1986 |
Excitatory amino acids and divalent cations in the kindling model of epilepsy.
Topics: Animals; Aspartic Acid; Calcium; Calcium-Binding Proteins; Cations, Divalent; Epilepsy; Glutamates; | 1986 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill | 1988 |
Alteration of amino acid content of cerebrospinal fluid from patients with epilepsy.
Topics: Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Epilepsy; Female; gamma-Aminobutyric Acid; Human | 1988 |
Role of the substantia nigra in the kindling model of limbic epilepsy.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Kindling, Neurologic; Limbic System; Musc | 1986 |
Long-term alterations in amino acid-induced ionic conductances in chronic epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cobalt; Electric Conductivity; Epilepsy; Glutamates; K | 1986 |
Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus.
Topics: Amino Acids; Animals; Aspartic Acid; Bicuculline; Calcium; Epilepsy; Ethanolamines; Extracellular Sp | 1986 |
Excitatory amino acids and epilepsy-induced changes in extracellular space size.
Topics: Animals; Aspartic Acid; Cats; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Kaini | 1986 |
Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.
Topics: Animals; Anticonvulsants; Aspartic Acid; Caudate Nucleus; Epilepsy; Ibotenic Acid; Male; N-Methylasp | 1987 |
Concentration of amino acids in the brain of cobalt-epileptic rat.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Cobalt; Disease Mode | 1973 |
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil | 1972 |
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro | 1972 |
Amino acids in the cobalt-induced epileptogenic and nonepileptogenic cat's cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy | 1972 |
[Changes in the levels of gamma-aminobutyric, glutamic and aspartic acids and glutamine in primary and reflected foci of epileptic activity].
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Electroencephalography; Epilepsy; Glutamate | 1970 |
Detection of argininosuccinic aciduria by gas chromatography.
Topics: Arginine; Aspartic Acid; Ataxia; Chemical Precipitation; Chromatography, Gas; Epilepsy; Esters; Huma | 1969 |