aspartic acid has been researched along with Epilepsies, Partial in 45 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 7.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Valproate (VPA) interferes with mitochondrial metabolism causing hyperammonemia, thereby shifting the balance reaction of glutamine (Gln)/glutamate (Glu) toward Gln." | 3.75 | Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. ( Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S, 2009) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 3.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Linear regression analyses between seizure duration and NAA/Cr decrease was not significant." | 2.69 | Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy. ( Andermann, F; Arnold, DL; Cendes, F; Dubeau, F; Li, LM; Miller, SP; Tasch, E, 2000) |
| "Important diagnostic value of HMRS in partial epilepsy without changes in MRI and with localized changes in EEG was documented." | 1.33 | [Preliminary assessment of HMRS clinical usefulness in children with partial epilepsy]. ( Gergont, A; Kaciński, M; Kroczka, S; Zajac, A, 2006) |
| "We present here a 4-year-old girl with gelastic epilepsy caused by hypothalamic hamartoma and report the magnetic resonance spectrometry and electroencephalographic (EEG) findings." | 1.31 | Gelastic seizure with hypothalamic hamartoma: proton magnetic resonance spectrometry and ictal electroencephalographic findings in a 4-year-old girl. ( Hayasaka, H; Kawamoto, Y; Nihira, H; Nikaido, K; Wakai, S, 2002) |
| "The patient developed a series of partial seizures during an 8 min period." | 1.28 | Seizure related elevations of extracellular amino acids in human focal epilepsy. ( Carlson, H; Hillered, L; Ronne-Engström, E; Ungerstedt, U, 1992) |
| "Before seizure, glutamate and aspartate concentration showed no significant changes in the S4 and S6 group compared with the Sh group." | 1.28 | [Sequential changes in content of excitatory amino acids in the epileptic focus during seizure]. ( Eguchi, T; Hirabayashi, H; Morimoto, T; Nakase, H; Sakaki, T; Tada, T, 1991) |
| "Patients with partial epilepsy had a pattern of amino acids in CSF similar to that in patients with primary generalized seizures." | 1.28 | Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients. ( Halonen, T; Hartikainen, P; Kutvonen, R; Matilainen, R; Pitkänen, A; Riekkinen, P, 1989) |
| "Glycine content was elevated markedly in some foci, whereas aspartic acid content was normal." | 1.26 | Amino acid abnormalities in epileptogenic foci. ( Hansen, S; Perry, TL, 1981) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Glycine content was markedly elevated in two of 16 epileptogenic foci." | 1.25 | Amino acids in human epileptogenic foci. ( Hansen, S; Kennedy, J; Perry, TL; Thompson, GB; Wada, JA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (28.89) | 18.7374 |
| 1990's | 14 (31.11) | 18.2507 |
| 2000's | 15 (33.33) | 29.6817 |
| 2010's | 3 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirov, II | 1 |
| Kuzniecky, R | 1 |
| Hetherington, HP | 1 |
| Soher, BJ | 1 |
| Davitz, MS | 1 |
| Babb, JS | 1 |
| Pardoe, HR | 1 |
| Pan, JW | 1 |
| Gonen, O | 1 |
| Leite, RA | 1 |
| Otaduy, MC | 1 |
| Silva, GE | 1 |
| Ferreira, ML | 1 |
| Aragão, Mde F | 1 |
| Bravo-Oro, A | 1 |
| Acosta-Yebra, D | 1 |
| Grimaldo-Zapata, IP | 1 |
| Reyes-Vaca, G | 1 |
| Garcia, M | 1 |
| Huppertz, HJ | 1 |
| Ziyeh, S | 1 |
| Buechert, M | 1 |
| Schumacher, M | 1 |
| Mader, I | 1 |
| Simister, RJ | 1 |
| McLean, MA | 2 |
| Barker, GJ | 2 |
| Duncan, JS | 2 |
| Lin, DD | 1 |
| Barker, PB | 1 |
| Kraut, MA | 1 |
| Comi, A | 1 |
| Vuori, K | 1 |
| Kankaanranta, L | 1 |
| Häkkinen, AM | 1 |
| Gaily, E | 1 |
| Valanne, L | 1 |
| Granström, ML | 1 |
| Joensuu, H | 1 |
| Blomstedt, G | 1 |
| Paetau, A | 1 |
| Lundbom, N | 1 |
| Cendes, F | 5 |
| Mueller, SG | 1 |
| D Laxer, K | 1 |
| Barakos, JA | 1 |
| Cashdollar, N | 1 |
| Flenniken, DL | 1 |
| Vermathen, P | 2 |
| Matson, GB | 3 |
| Weiner, MW | 3 |
| Varho, T | 1 |
| Komu, M | 1 |
| Sonninen, P | 1 |
| Lähdetie, J | 1 |
| Holopainen, IE | 1 |
| Milh, M | 1 |
| Becq, H | 1 |
| Villeneuve, N | 1 |
| Ben-Ari, Y | 1 |
| Aniksztejn, L | 1 |
| Krsek, P | 1 |
| Hajek, M | 1 |
| Dezortova, M | 1 |
| Jiru, F | 1 |
| Skoch, A | 1 |
| Marusic, P | 1 |
| Zamecnik, J | 1 |
| Kyncl, M | 1 |
| Tichy, M | 1 |
| Komarek, V | 1 |
| Kaciński, M | 1 |
| Zajac, A | 1 |
| Kroczka, S | 1 |
| Gergont, A | 1 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Engelsen, B | 1 |
| Elsayed, S | 1 |
| Perry, TL | 2 |
| Hansen, S | 2 |
| Andermann, F | 6 |
| Silver, K | 1 |
| Arnold, DL | 7 |
| Garcia, PA | 1 |
| Laxer, KD | 2 |
| van der Grond, J | 1 |
| Hugg, JW | 1 |
| Ende, G | 1 |
| Knowlton, RC | 1 |
| Chapman, AG | 1 |
| Elwes, RD | 1 |
| Millan, MH | 1 |
| Polkey, CE | 1 |
| Meldrum, BS | 1 |
| Stanley, JA | 1 |
| Dubeau, F | 4 |
| Pouwels, PJ | 1 |
| Brockmann, K | 1 |
| Kruse, B | 1 |
| Wilken, B | 1 |
| Wick, M | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 1 |
| Krakow, K | 1 |
| Wieshmann, UC | 1 |
| Woermann, FG | 1 |
| Symms, MR | 1 |
| Lemieux, L | 1 |
| Allen, PJ | 1 |
| Fish, DR | 1 |
| Sherwin, AL | 5 |
| Maton, BM | 1 |
| Najm, IM | 1 |
| Wang, Y | 1 |
| Lüders, HO | 1 |
| Ng, TC | 1 |
| Serles, W | 1 |
| Li, LM | 4 |
| Caramanos, Z | 1 |
| Gotman, J | 1 |
| Miller, SP | 1 |
| Tasch, E | 1 |
| Savic, I | 1 |
| Thomas, AM | 1 |
| Ke, Y | 1 |
| Curran, J | 1 |
| Fried, I | 1 |
| Engel, J | 1 |
| Wakai, S | 1 |
| Nikaido, K | 1 |
| Nihira, H | 1 |
| Kawamoto, Y | 1 |
| Hayasaka, H | 1 |
| Collins, RC | 1 |
| Mehta, S | 1 |
| Van Gelder, NM | 4 |
| Sacks, C | 1 |
| Anderman, F | 1 |
| Kennedy, J | 1 |
| Wada, JA | 1 |
| Thompson, GB | 1 |
| Carlson, H | 1 |
| Ronne-Engström, E | 1 |
| Ungerstedt, U | 1 |
| Hillered, L | 1 |
| Nakase, H | 1 |
| Tada, T | 1 |
| Eguchi, T | 1 |
| Hirabayashi, H | 1 |
| Morimoto, T | 1 |
| Sakaki, T | 1 |
| Schüler, P | 1 |
| Stefan, H | 1 |
| Schuierer, G | 1 |
| Hentschel, D | 1 |
| Ladebeck, R | 1 |
| Wittig, R | 1 |
| Huk, W | 1 |
| Neundörfer, B | 1 |
| Matthews, PM | 1 |
| Crill, WE | 1 |
| Schwindt, PC | 1 |
| Flatman, JA | 1 |
| Stafstrom, CE | 1 |
| Spain, W | 1 |
| Pitkänen, A | 1 |
| Matilainen, R | 1 |
| Halonen, T | 1 |
| Kutvonen, R | 1 |
| Hartikainen, P | 1 |
| Riekkinen, P | 1 |
| Kish, SJ | 1 |
| Dixon, LM | 1 |
| Abdul-Ghani, AS | 1 |
| Rasmussen, T | 2 |
| Courtois, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001] | Phase 1 | 4 participants (Actual) | Interventional | 2006-02-28 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aspartic acid and Epilepsies, Partial
| Article | Year |
|---|---|
[Reversible cortical atrophy secondary to anti-NMDA receptor antibody encephalitis].
Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Anticonvulsants; Aphasia, Broca; Aspartic Acid; Atr | 2015 |
MRS and fMRI in partial epilepsies.
Topics: Aspartic Acid; Biomarkers; Brain; Epilepsies, Partial; Humans; Magnetic Resonance Imaging; Magnetic | 2003 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
Neuroactive amino acids in focally epileptic human brain: a review.
Topics: Aspartic Acid; Brain; Epilepsies, Partial; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic | 1999 |
1 trial available for aspartic acid and Epilepsies, Partial
| Article | Year |
|---|---|
Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain Neoplasms; Child; C | 2000 |
40 other studies available for aspartic acid and Epilepsies, Partial
| Article | Year |
|---|---|
Whole brain neuronal abnormalities in focal epilepsy quantified with proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Cohort Studies; Epilepsies, Partial; Female; Humans; Magnetic | 2018 |
Proton magnetic spectroscopy agreed better with magnetic resonance image to lateralization of epileptogenic zone than with surface electroencephalography.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cross-Sectional Studies; Elect | 2013 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, | 2009 |
A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Carnosine; Epilepsies, Partial; Epilepsy, Generalized; Female; gam | 2003 |
Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging.
Topics: Aspartic Acid; Brain; Brain Chemistry; Cerebrovascular Circulation; Choline; Epilepsies, Partial; Hu | 2003 |
Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Cerebral Cortex; Child; Choline; Creatine; Diagnosis, | 2004 |
Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Electroencephalography; Epilepsi | 2004 |
Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Epilepsies, Partial; Female; Functional Lateral | 2005 |
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease | 2007 |
(1)H MR spectroscopic imaging in patients with MRI-negative extratemporal epilepsy: correlation with ictal onset zone and histopathology.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Child; Choline; Creatine; Electroencephalography; E | 2007 |
[Preliminary assessment of HMRS clinical usefulness in children with partial epilepsy].
Topics: Adolescent; Aspartic Acid; Brain; Child; Choline; Electroencephalography; Epilepsies, Partial; Femal | 2006 |
Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: an effect of medication?
Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Drug Therapy, Combination; Epilepsie | 1984 |
Amino acid abnormalities in epileptogenic foci.
Topics: Adolescent; Adult; Aged; Amino Acids; Aspartic Acid; Cerebral Cortex; Child; Epilepsies, Partial; Fr | 1981 |
Imaging of axonal damage in vivo in Rasmussen's syndrome.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Child; Chronic Disease; Creatine; Disease Progression; E | 1995 |
Correlation of seizure frequency with N-acetyl-aspartate levels determined by 1H magnetic resonance spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Creatine; Epilepsies, Partial; Humans; Image Processing, Co | 1997 |
Hippocampal N-acetylaspartate in neocortical epilepsy and mesial temporal lobe epilepsy.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temp | 1997 |
Role of glutamate and aspartate in epileptogenesis; contribution of microdialysis studies in animal and man.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Electroencephalography; Epilepsies, Partial; Epilepsy; | 1996 |
Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Choline; Electrodes, Implanted; Epilepsies, Partial; Epilepsy | 1998 |
Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS.
Topics: Adolescent; Age Factors; Aspartic Acid; Basal Ganglia; Brain; Brain Neoplasms; Cerebellum; Child; Ch | 1999 |
Multimodal MR imaging: functional, diffusion tensor, and chemical shift imaging in a patient with localization-related epilepsy.
Topics: Adult; Anisotropy; Aspartic Acid; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Huma | 1999 |
Postictal in situ MRS brain lactate in the rat kindling model.
Topics: Animals; Aspartic Acid; Brain Mapping; Creatine; Disease Models, Animal; Electroencephalography; Epi | 1999 |
Relation of interictal spike frequency to 1H-MRSI-measured NAA/Cr.
Topics: Adolescent; Adult; Aspartic Acid; Creatine; Electroencephalography; Epilepsies, Partial; Epilepsy, F | 1999 |
Spatial extent of neuronal metabolic dysfunction measured by proton MR spectroscopic imaging in patients with localization-related epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Child; Creatine; Electroencephalography; Epilepsies, Partial; Epil | 2000 |
Proton magnetic resonance spectroscopic imaging studies in patients with newly diagnosed partial epilepsy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Carbamazepine; Creatine; Epilepsies, Partial; Epilepsy, Tempo | 2000 |
In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Creatine; Diagnosis, Diff | 2000 |
Gelastic seizure with hypothalamic hamartoma: proton magnetic resonance spectrometry and ictal electroencephalographic findings in a 4-year-old girl.
Topics: Aspartic Acid; Cerebral Cortex; Child, Preschool; Choline; Creatine; Energy Metabolism; Epilepsies, | 2002 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Biochemical observations following administration of taurine to patients with epilepsy.
Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool | 1975 |
Amino acids in human epileptogenic foci.
Topics: Adolescent; Adult; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Child; Cystathionine; Epile | 1975 |
Seizure related elevations of extracellular amino acids in human focal epilepsy.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cerebral Cortex; Dialysis; Electroencephalography; Epilepsie | 1992 |
[Sequential changes in content of excitatory amino acids in the epileptic focus during seizure].
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Cats; Dialysis; Epilepsies, Partial; Extracellular Sp | 1991 |
[4-Tesla 1H MR spectroscopy in patients with temporal lobe epilepsy].
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Partial; Epileps | 1991 |
A proton magnetic resonance spectroscopy study of focal epilepsy in humans.
Topics: Aspartic Acid; Brain; Child; Chronic Disease; Encephalitis; Epilepsies, Partial; Female; Humans; Lac | 1990 |
Inward currents in cat neocortical neurons studied in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Electric Conductivity; Epilepsies, Partial; | 1986 |
Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients.
Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Carnosine; Dipeptides; Epilepsies, Partial; Epilepsy; | 1989 |
Aspartic acid aminotransferase activity is increased in actively spiking compared with non-spiking human epileptic cortex.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Aspartic Acid; Biopsy; Cerebral Cortex; Epilepsies, | 1988 |
Effect of alpha-amino-4-phosphonobutyrate on the release of endogenous glutamate and aspartate from cortical synaptosomes of epileptic rats.
Topics: Aminobutyrates; Animals; Anticonvulsants; Aspartic Acid; Cobalt; Epilepsies, Partial; Female; gamma- | 1985 |
Proceedings: An abnormality of secondary energy resources in epileptogenic human brain.
Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Cerebral Cortex; Child; Energy Metabolism; Epilepsies | 1972 |
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil | 1972 |
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro | 1972 |