aspartic acid has been researched along with Disease Exacerbation in 185 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 9.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 7.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients." | 7.74 | Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. ( Basurto-Islas, G; Binder, LI; García-Sierra, F; Guillozet-Bongaarts, AL; Luna-Muñoz, J; Mena, R, 2008) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 5.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle." | 3.96 | Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020) |
| "Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)." | 3.85 | Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017) |
| "To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS)." | 3.80 | Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. ( Blinkenberg, M; Hanson, LG; Mathiesen, HK; Paulson, OB; Skimminge, A; Sorensen, PS; Wu, X, 2014) |
| "Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy." | 3.80 | 3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 3.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients." | 3.74 | Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. ( Basurto-Islas, G; Binder, LI; García-Sierra, F; Guillozet-Bongaarts, AL; Luna-Muñoz, J; Mena, R, 2008) |
| " Primary central nervous system lymphoma (PCNSL) is a highly aggressive tumor responsive to high-dose methotrexate based regimens." | 3.73 | Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. ( Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL, 2005) |
| " We also did not find a correlation between the amount of Glx and the initial Glasgow Coma Scale score, duration of coma, nor with changes in spectral metabolites, including N-acetyl aspartate, choline, and myoinositol." | 3.72 | Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. ( Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K, 2004) |
| " Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination." | 3.72 | Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003) |
| "Late infantile metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder that causes severe demyelination of the nervous system." | 2.75 | Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. ( Barton, NW; Fogh, J; Hanson, LG; i Dali, C; Lund, AM; Nair, N, 2010) |
| "To evaluate the mechanisms underlying disease progression in the early phase of PPMS by measuring metabolite concentrations in normal-appearing white matter (NAWM) and cortical gray matter (CGM) and to assess their relationship with clinical outcomes." | 2.71 | Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis. ( Chard, DT; Ingle, GT; McLean, MA; Miller, DH; Ramió-Torrentà, L; Sastre-Garriga, J; Thompson, AJ, 2005) |
| " Treatment was well tolerated; 4/27 patients experienced > or = ECOG grade 3 toxicity at full 5-FU dosage (500 mg/m2 bolus/infusion)." | 2.67 | A phase I-II study of N-(phosphonacetyl)-L-aspartic acid (PALA) added to 5-fluorouracil and folinic acid in advanced colorectal cancer. ( Canney, PA; Cassidy, J; Jodrell, DI; Kaye, SB; Kerr, DJ; Oster, W; Steward, WP; Yosef, H, 1994) |
| "Axonal damage in multiple sclerosis has become an important issue." | 2.41 | Imaging axonal damage in multiple sclerosis by means of MR spectroscopy. ( Arnold, DL; Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Mortilla, M; Narayanan, S, 2000) |
| "However, an objective measure of disease progression and therapeutic response is sorely needed." | 2.40 | Biological markers in the diagnosis and treatment of ALS. ( Arnold, DL; Cashman, NR; Kalra, S, 1999) |
| "Inhibiting pancreatic cancer progression after chemotherapy is a rational application of this metabolism-disturbing combination strategy." | 1.48 | Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy. ( Chen, C; Fei, K; Guo, L; Ju, R; Li, J; Li, S; Ye, C; Zhang, D; Zhu, L, 2018) |
| "Schizophrenia is a chronic, often progressive, disorder." | 1.48 | Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. ( Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM, 2018) |
| "Background GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1, encoding β-galactosidase." | 1.43 | MRI/MRS as a surrogate marker for clinical progression in GM1 gangliosidosis. ( Adams, D; Baker, EH; Golas, G; Johnston, J; Kwon, HJ; Latour, Y; Portner, C; Regier, DS; Thomas, S; Tifft, CJ; Vezina, G; Wiggs, E; Yang, S, 2016) |
| "Patients with colorectal tumors that express increased levels of SLC25A22 have shorter survival times than patients whose tumors have lower levels." | 1.43 | SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. ( Cai, Z; Chen, H; Cheng, KW; Go, MY; Jin, Y; Kang, W; Li, W; Li, X; Ng, SS; Qian, Y; Sung, JJ; To, KF; Tong, JH; Wong, CC; Wu, JL; Xu, J; Yu, J, 2016) |
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| "Canavan disease is a major point of focus for efforts to define NAA function, with available evidence suggesting NAA serves as an acetyl donor for fatty acid synthesis during myelination." | 1.43 | N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. ( Bilaniuk, LT; De Vivo, DC; Francis, JS; Gray, SJ; Janson, CG; Leone, P; Markov, V; McCown, TJ; Samulski, RJ; Wang, DJ; Wojtas, I, 2016) |
| "Amnestic mild cognitive impairment (aMCI) has been considered to be a transitional state between healthy aging and very mild Alzheimer's disease (AD)." | 1.42 | [Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy]. ( Akiguchi, I; Shiino, A; Watanabe, T, 2015) |
| "We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD)." | 1.40 | Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. ( Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M, 2014) |
| "A novel leukoencephalopathy, termed hypomyelinating leukoencephalopathy affecting early myelinating structures (HEMS), was recently described." | 1.39 | Novel hypomyelinating leukoencephalopathy affecting early myelinating structures: clinical course in two brothers. ( Ariaudo, G; Balottin, U; Bastianello, S; Orcesi, S; Pichiecchio, A; Tonduti, D; van der Knaap, MS; Wolf, NI, 2013) |
| "Dominant optic atrophy is a rare inherited optic nerve degeneration caused by mutations in the mitochondrial fusion gene OPA1." | 1.38 | The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. ( Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J, 2012) |
| "Neurological involvement in X-linked mucopolysaccharidosis type II (Hunter syndrome) is indicative of more severe disease, but is not attenuated by current enzyme replacement therapy which does not significantly penetrate the blood-brain barrier." | 1.36 | Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome). ( Davies, NP; Davison, JE; Gissen, P; Hendriksz, CJ; Peet, AC; Sun, Y, 2010) |
| "Fourteen patients with juvenile absence epilepsy with typical absence seizures and 10 healthy volunteer controls were included in this study." | 1.36 | A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages. ( Erdinc, O; Gumustas, OG; Kabay, SC; Karaman, HO; Ozden, H, 2010) |
| "He was diagnosed as having familial hemophagocytic lymphohistiocytosis and treated with the HLH 2004 protocol." | 1.35 | Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis. ( Gibikote, S; Kumar, S; Moses, PD; Puliyel, MM; Rose, W, 2009) |
| "High grade gliomas are known to release excitotoxic concentrations of glutamate, a process thought to contribute to their malignant phenotype through enhanced autocrine stimulation of their proliferation and destruction of the surrounding nervous tissue." | 1.35 | Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. ( Abarca-Quinones, J; Gallez, B; Hermans, E; Jordan, BF; Maloteaux, JM; Vanhoutte, N, 2009) |
| "Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion." | 1.35 | Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. ( Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH, 2008) |
| "Prion diseases are fatal chronic neurodegenerative diseases." | 1.34 | MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. ( Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P, 2007) |
| "The data suggest that the Weill Cornell late infantile neuronal ceroid lipofuscinosis (LINCL) scale, together with several of the MRI measurements, may be useful in the assessment of severity and progression of LINCL and for the evaluation of novel therapeutic strategies." | 1.34 | Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. ( Ballon, D; Crystal, RG; Dyke, JP; Hackett, NR; Heier, L; Hollmann, C; Kaplitt, MG; Kekatpure, MV; Kosofsky, B; Mao, X; Shungu, D; Sondhi, D; Souweidane, MM; Worgall, S, 2007) |
| "The patients with IDDMS were older at diagnosis and had a greater body mass index (BMI) than those with IDDM (A + E)." | 1.33 | Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. ( Kazahari, M; Kikuchi, N; Koike, A; Matsuura, N; Nomoto, K; Ohtsu, S; Takubo, N; Yokota, F, 2005) |
| "In these patients spasticity began in the legs and progressed slowly and steadily." | 1.32 | Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes? ( Butman, JA; Floeter, MK; Pagan, F; Statland, J; Zhai, P, 2003) |
| "The fulminating form of subacute sclerosing panencephalitis is an extremely rare condition." | 1.32 | Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings. ( Alkan, A; Aslan, M; Kutlu, R; Sarac, K; Sigirci, A; Yakinci, C, 2004) |
| "A slowly progressive sensory ataxia and tremor manifested at the age of 3 to 16 years and distal spasticity in adolescence." | 1.32 | Five new cases of a recently described leukoencephalopathy with high brain lactate. ( Aärimaa, T; Autti, T; Häkkinen, AM; Koillinen, H; Kuusi, T; Linnankivi, T; Lönnqvist, T; Lundbom, N; Pihko, H; Sainio, K; Valanne, L, 2004) |
| "Pretreatment with pargyline attenuated the MPTP-induced clinical signs, MRI and MRS changes, and the histopathological and immunoreactivity alterations." | 1.32 | Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. ( Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA, 2003) |
| "Bone metastasis, clinical T-stage, tumor grade, and serum prostate-specific antigen (PSA) have been shown to have prognostic importance in the outcome of prostate cancer." | 1.31 | Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7. ( Costa, S; Ferreira, P; Lopes, C; Medeiros, RM; Morais, A; Oliveira, J; Pinto, D; Vasconcelos, A, 2002) |
| "Circulating tumor cells were identified in all four patients." | 1.31 | K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells. ( Krygier, S; Luchtefeld, MA; Senagore, AJ; Thebo, JS, 2001) |
| "The diagnosis of gliomatosis cerebri with MR imaging is known to be difficult." | 1.31 | MR spectroscopy in gliomatosis cerebri. ( Bendszus, M; Burger, R; Klein, R; Schichor, C; Solymosi, L; Tonn, JC; Warmuth-Metz, M, 2000) |
| "In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume." | 1.31 | Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease. ( Adalsteinsson, E; Kleinhans, N; Pfefferbaum, A; Spielman, DM; Sullivan, EV, 2000) |
| "Infantile hydrocephalus is most often caused by an obstruction in the cerebrospinal fluid flow pathway and results in ventricular dilatation and chronic trauma to the surrounding brain." | 1.30 | Progressive changes in cortical metabolites at three stages of infantile hydrocephalus studied by in vitro NMR spectroscopy. ( Andersohn, RW; Harris, NG; Jones, HC; Rocca, JR, 1997) |
| "The metabolic disturbances indicate disease progression but are less pronounced than in older patients with hemimegalencephaly." | 1.30 | Proton magnetic resonance spectroscopy of linear nevus sebaceus syndrome. ( Christen, HJ; Frahm, J; Hanefeld, FA; Kruse, B; Pouwels, PJ, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (8.65) | 18.2507 |
| 2000's | 94 (50.81) | 29.6817 |
| 2010's | 72 (38.92) | 24.3611 |
| 2020's | 3 (1.62) | 2.80 |
| Authors | Studies |
|---|---|
| Blicher, JU | 1 |
| Eskildsen, SF | 1 |
| Stærmose, TG | 1 |
| Møller, AT | 1 |
| Figlewski, K | 1 |
| Near, J | 1 |
| Kochalska, K | 1 |
| Oakden, W | 1 |
| Słowik, T | 1 |
| Chudzik, A | 1 |
| Pankowska, A | 1 |
| Łazorczyk, A | 1 |
| Kozioł, P | 1 |
| Andres-Mach, M | 1 |
| Pietura, R | 1 |
| Rola, R | 1 |
| Stanisz, GJ | 1 |
| Orzylowska, A | 1 |
| Solanky, BS | 1 |
| John, NA | 1 |
| DeAngelis, F | 1 |
| Stutters, J | 1 |
| Prados, F | 1 |
| Schneider, T | 1 |
| Parker, RA | 1 |
| Weir, CJ | 1 |
| Monteverdi, A | 1 |
| Plantone, D | 1 |
| Doshi, A | 1 |
| MacManus, D | 1 |
| Marshall, I | 2 |
| Barkhof, F | 1 |
| Gandini Wheeler-Kingshott, CAM | 1 |
| Chataway, J | 1 |
| Ta, D | 1 |
| Ishaque, A | 1 |
| Srivastava, O | 1 |
| Hanstock, C | 2 |
| Seres, P | 1 |
| Eurich, DT | 1 |
| Luk, C | 1 |
| Briemberg, H | 1 |
| Frayne, R | 1 |
| Genge, AL | 1 |
| Graham, SJ | 1 |
| Korngut, L | 1 |
| Zinman, L | 1 |
| Kalra, S | 3 |
| Kirov, II | 1 |
| Liu, S | 1 |
| Tal, A | 1 |
| Wu, WE | 1 |
| Davitz, MS | 1 |
| Babb, JS | 3 |
| Rusinek, H | 1 |
| Herbert, J | 1 |
| Gonen, O | 5 |
| Giacanelli, M | 1 |
| Petrucci, A | 1 |
| Lispi, L | 1 |
| Luna, R | 1 |
| Neri, G | 1 |
| Gurrieri, F | 1 |
| Angelini, C | 1 |
| Waragai, M | 2 |
| Moriya, M | 2 |
| Nojo, T | 1 |
| Robertson, DS | 1 |
| Joers, JM | 1 |
| Deelchand, DK | 2 |
| Lyu, T | 1 |
| Emir, UE | 1 |
| Hutter, D | 1 |
| Gomez, CM | 1 |
| Bushara, KO | 1 |
| Eberly, LE | 2 |
| Öz, G | 3 |
| Kim, D | 1 |
| Hwang, H | 1 |
| Choi, S | 1 |
| Kwon, SH | 1 |
| Lee, S | 1 |
| Park, JH | 1 |
| Kim, S | 2 |
| Ko, HS | 1 |
| Ju, R | 1 |
| Fei, K | 1 |
| Li, S | 1 |
| Chen, C | 1 |
| Zhu, L | 1 |
| Li, J | 1 |
| Zhang, D | 1 |
| Guo, L | 1 |
| Ye, C | 1 |
| Polacek, H | 1 |
| Kantorova, E | 1 |
| Hnilicova, P | 1 |
| Grendar, M | 1 |
| Zelenak, K | 1 |
| Kurca, E | 1 |
| Sivaraman, S | 1 |
| Kraguljac, NV | 1 |
| White, DM | 1 |
| Morgan, CJ | 1 |
| Gonzales, SS | 1 |
| Lahti, AC | 1 |
| Weng, YC | 1 |
| Hsiao, IT | 1 |
| Huang, CY | 1 |
| Huang, KL | 1 |
| Liu, CH | 1 |
| Chang, TY | 1 |
| Yen, TC | 1 |
| Lin, KJ | 1 |
| Huang, CC | 1 |
| Cheong, I | 1 |
| Marjańska, M | 1 |
| Manousakis, G | 1 |
| Guliani, G | 1 |
| Walk, D | 1 |
| Terry, AR | 1 |
| Hay, N | 1 |
| Hansen, TM | 1 |
| Brock, B | 1 |
| Juhl, A | 1 |
| Drewes, AM | 1 |
| Vorum, H | 1 |
| Andersen, CU | 1 |
| Jakobsen, PE | 1 |
| Karmisholt, J | 1 |
| Frøkjær, JB | 1 |
| Brock, C | 1 |
| Kantarci, K | 4 |
| Gongvatana, A | 1 |
| Harezlak, J | 1 |
| Buchthal, S | 1 |
| Daar, E | 1 |
| Schifitto, G | 1 |
| Campbell, T | 1 |
| Taylor, M | 1 |
| Singer, E | 1 |
| Algers, J | 1 |
| Zhong, J | 1 |
| Brown, M | 1 |
| McMahon, D | 1 |
| So, YT | 1 |
| Mi, D | 1 |
| Heaton, R | 1 |
| Robertson, K | 1 |
| Yiannoutsos, C | 1 |
| Cohen, RA | 1 |
| Navia, B | 1 |
| Stromillo, ML | 2 |
| Giorgio, A | 2 |
| Rossi, F | 1 |
| Battaglini, M | 2 |
| Hakiki, B | 1 |
| Malentacchi, G | 1 |
| Santangelo, M | 1 |
| Gasperini, C | 1 |
| Bartolozzi, ML | 2 |
| Portaccio, E | 1 |
| Amato, MP | 1 |
| De Stefano, N | 8 |
| Darrah, E | 1 |
| Giles, JT | 1 |
| Ols, ML | 1 |
| Bull, HG | 1 |
| Andrade, F | 1 |
| Rosen, A | 1 |
| Bellenberg, B | 1 |
| Busch, M | 1 |
| Trampe, N | 1 |
| Gold, R | 1 |
| Chan, A | 1 |
| Lukas, C | 1 |
| Natsubori, T | 1 |
| Inoue, H | 1 |
| Abe, O | 1 |
| Takano, Y | 1 |
| Iwashiro, N | 1 |
| Aoki, Y | 1 |
| Koike, S | 1 |
| Yahata, N | 1 |
| Katsura, M | 1 |
| Gonoi, W | 1 |
| Sasaki, H | 1 |
| Takao, H | 1 |
| Kasai, K | 1 |
| Yamasue, H | 1 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Lin, Y | 1 |
| Yao, J | 1 |
| Chen, Y | 1 |
| Pang, L | 1 |
| Li, H | 1 |
| Cao, Z | 1 |
| You, K | 1 |
| Dai, H | 1 |
| Wu, R | 1 |
| Wu, X | 1 |
| Hanson, LG | 2 |
| Skimminge, A | 1 |
| Sorensen, PS | 1 |
| Paulson, OB | 1 |
| Mathiesen, HK | 1 |
| Blinkenberg, M | 1 |
| Hata, S | 1 |
| Suzuki, T | 1 |
| Ishii, R | 1 |
| Fujii, C | 1 |
| Tokuda, T | 1 |
| Arai, H | 1 |
| Ohrui, T | 1 |
| Higuchi, S | 1 |
| Yoshida, M | 1 |
| Igarashi, K | 1 |
| Iwai, N | 1 |
| Uemura, K | 1 |
| Llufriu, S | 1 |
| Kornak, J | 1 |
| Ratiney, H | 1 |
| Oh, J | 1 |
| Brenneman, D | 1 |
| Cree, BA | 1 |
| Sampat, M | 1 |
| Hauser, SL | 1 |
| Nelson, SJ | 3 |
| Pelletier, D | 1 |
| Muruganandham, M | 1 |
| Clerkin, PP | 1 |
| Smith, BJ | 1 |
| Anderson, CM | 1 |
| Morris, A | 1 |
| Capizzano, AA | 1 |
| Magnotta, V | 1 |
| McGuire, SM | 1 |
| Smith, MC | 1 |
| Bayouth, JE | 1 |
| Buatti, JM | 1 |
| Trentini, A | 1 |
| Comabella, M | 1 |
| Tintoré, M | 1 |
| Koel-Simmelink, MJ | 2 |
| Killestein, J | 1 |
| Roos, B | 1 |
| Rovira, A | 2 |
| Korth, C | 1 |
| Ottis, P | 1 |
| Blankenstein, MA | 1 |
| Montalban, X | 2 |
| Bellini, T | 1 |
| Teunissen, CE | 2 |
| Zhou, L | 1 |
| Fan, Y | 1 |
| Rollet-Kurhajec, KC | 1 |
| Moodie, EE | 1 |
| Walmsley, S | 1 |
| Cooper, C | 1 |
| Pick, N | 1 |
| Klein, MB | 1 |
| Watanabe, T | 2 |
| Shiino, A | 1 |
| Akiguchi, I | 1 |
| Garcia-Montero, AC | 1 |
| Jara-Acevedo, M | 1 |
| Alvarez-Twose, I | 1 |
| Teodosio, C | 1 |
| Sanchez-Muñoz, L | 1 |
| Muñiz, C | 1 |
| Muñoz-Gonzalez, JI | 1 |
| Mayado, A | 1 |
| Matito, A | 1 |
| Caldas, C | 1 |
| Morgado, JM | 1 |
| Escribano, L | 1 |
| Orfao, A | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Regier, DS | 1 |
| Kwon, HJ | 1 |
| Johnston, J | 1 |
| Golas, G | 1 |
| Yang, S | 1 |
| Wiggs, E | 1 |
| Latour, Y | 1 |
| Thomas, S | 1 |
| Portner, C | 1 |
| Adams, D | 1 |
| Vezina, G | 1 |
| Baker, EH | 1 |
| Tifft, CJ | 1 |
| Liemburg, E | 1 |
| Sibeijn-Kuiper, A | 1 |
| Bais, L | 1 |
| Pijnenborg, G | 1 |
| Knegtering, H | 1 |
| van der Velde, J | 1 |
| Opmeer, E | 1 |
| de Vos, A | 1 |
| Dlabac-De Lange, J | 1 |
| Wunderink, L | 1 |
| Aleman, A | 1 |
| Sedel, F | 1 |
| Chabrol, B | 1 |
| Audoin, B | 2 |
| Kaphan, E | 1 |
| Tranchant, C | 1 |
| Burzykowski, T | 1 |
| Tourbah, A | 1 |
| Vanier, MT | 1 |
| Galanaud, D | 1 |
| Löbel, U | 1 |
| Hwang, S | 1 |
| Edwards, A | 1 |
| Li, Y | 1 |
| Li, X | 2 |
| Broniscer, A | 1 |
| Patay, Z | 1 |
| Wong, CC | 1 |
| Qian, Y | 1 |
| Xu, J | 1 |
| Kang, W | 1 |
| Tong, JH | 1 |
| To, KF | 1 |
| Jin, Y | 1 |
| Li, W | 1 |
| Chen, H | 1 |
| Go, MY | 1 |
| Wu, JL | 1 |
| Cheng, KW | 1 |
| Ng, SS | 1 |
| Sung, JJ | 1 |
| Cai, Z | 1 |
| Yu, J | 1 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 2 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 1 |
| Saudou, F | 1 |
| Humbert, S | 1 |
| Yang, XW | 1 |
| Osmand, A | 1 |
| Steffan, JS | 1 |
| Masliah, E | 2 |
| Finkbeiner, S | 1 |
| Pardini, M | 1 |
| Botzkowski, D | 1 |
| Müller, S | 1 |
| Vehoff, J | 1 |
| Kuhle, J | 1 |
| Ruberte, E | 1 |
| Würfel, J | 1 |
| Gass, A | 1 |
| Valmaggia, C | 1 |
| Tettenborn, B | 1 |
| Putzki, N | 1 |
| Yaldizli, Ö | 1 |
| Sawiak, SJ | 1 |
| Wood, NI | 1 |
| Morton, AJ | 1 |
| Francis, JS | 1 |
| Wojtas, I | 1 |
| Markov, V | 1 |
| Gray, SJ | 1 |
| McCown, TJ | 1 |
| Samulski, RJ | 1 |
| Bilaniuk, LT | 1 |
| Wang, DJ | 1 |
| De Vivo, DC | 1 |
| Janson, CG | 1 |
| Leone, P | 1 |
| Boonzaier, NR | 1 |
| Larkin, TJ | 1 |
| Matys, T | 1 |
| van der Hoorn, A | 1 |
| Yan, JL | 1 |
| Price, SJ | 1 |
| Kato, I | 1 |
| Oya, T | 1 |
| Suzuki, H | 1 |
| Takasawa, K | 1 |
| Ichsan, AM | 1 |
| Nakada, S | 1 |
| Ishii, Y | 1 |
| Shimada, Y | 1 |
| Sasahara, M | 1 |
| Tobe, K | 1 |
| Takasawa, S | 1 |
| Okamoto, H | 1 |
| Hiraga, K | 1 |
| Sankar, T | 1 |
| Caramanos, Z | 1 |
| Assina, R | 1 |
| Villemure, JG | 1 |
| Leblanc, R | 1 |
| Langleben, A | 1 |
| Arnold, DL | 10 |
| Preul, MC | 1 |
| Traka, M | 1 |
| Wollmann, RL | 1 |
| Cerda, SR | 1 |
| Dugas, J | 1 |
| Barres, BA | 1 |
| Popko, B | 1 |
| Baik, SK | 1 |
| Kim, YW | 1 |
| Kim, HJ | 1 |
| Lee, JW | 1 |
| Cho, BM | 1 |
| Kim, DH | 1 |
| Choi, SH | 1 |
| Lee, SH | 1 |
| Chang, KH | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Chappell, FM | 1 |
| Armitage, PA | 1 |
| Bastin, ME | 1 |
| Wardlaw, JM | 1 |
| Thambisetty, M | 1 |
| Hye, A | 1 |
| Foy, C | 1 |
| Daly, E | 1 |
| Glover, A | 1 |
| Cooper, A | 1 |
| Simmons, A | 1 |
| Murphy, D | 1 |
| Lovestone, S | 1 |
| Giovagnoli, AR | 1 |
| Aresi, A | 1 |
| Reati, F | 1 |
| Riva, A | 1 |
| Gobbo, C | 1 |
| Bizzi, A | 1 |
| Pyra, T | 1 |
| Hui, B | 1 |
| Concha, L | 1 |
| Wong, JC | 1 |
| Beaulieu, C | 1 |
| Johnston, W | 1 |
| Imamura, A | 1 |
| Miyajima, H | 1 |
| Ito, R | 1 |
| Orii, KO | 1 |
| Iacobaeus, E | 1 |
| Khademi, M | 1 |
| Brundin, L | 1 |
| Norgren, N | 1 |
| Schepens, M | 1 |
| Bouwman, F | 1 |
| Twaalfhoven, HA | 1 |
| Blom, HJ | 1 |
| Jakobs, C | 1 |
| Dijkstra, CD | 1 |
| Vanhoutte, N | 1 |
| Abarca-Quinones, J | 1 |
| Jordan, BF | 1 |
| Gallez, B | 1 |
| Maloteaux, JM | 1 |
| Hermans, E | 1 |
| Lentz, MR | 2 |
| Kim, WK | 1 |
| Lee, V | 1 |
| Bazner, S | 1 |
| Halpern, EF | 1 |
| Venna, N | 1 |
| Williams, K | 1 |
| Rosenberg, ES | 1 |
| González, RG | 2 |
| Weigand, SD | 2 |
| Przybelski, SA | 1 |
| Shiung, MM | 1 |
| Whitwell, JL | 1 |
| Negash, S | 1 |
| Knopman, DS | 2 |
| Boeve, BF | 3 |
| O'Brien, PC | 3 |
| Petersen, RC | 3 |
| Jack, CR | 3 |
| Pilatus, U | 1 |
| Lais, C | 1 |
| Rochmont, Adu M | 1 |
| Kratzsch, T | 1 |
| Frölich, L | 1 |
| Maurer, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pantel, J | 1 |
| Benedetti, B | 1 |
| Rovaris, M | 2 |
| Rocca, MA | 1 |
| Caputo, D | 1 |
| Zaffaroni, M | 1 |
| Capra, R | 1 |
| Bertolotto, A | 1 |
| Martinelli, V | 2 |
| Comi, G | 3 |
| Filippi, M | 3 |
| Kabay, SC | 1 |
| Gumustas, OG | 1 |
| Karaman, HO | 1 |
| Ozden, H | 1 |
| Erdinc, O | 1 |
| Puliyel, MM | 1 |
| Rose, W | 1 |
| Kumar, S | 1 |
| Moses, PD | 1 |
| Gibikote, S | 1 |
| Sobti, RC | 1 |
| Berhane, N | 1 |
| Mehedi, SA | 1 |
| Kler, R | 1 |
| Hosseini, SA | 1 |
| Kuttiat, V | 1 |
| Wanchu, A | 1 |
| Zahr, NM | 1 |
| Crawford, EL | 1 |
| Hsu, O | 1 |
| Vinco, S | 1 |
| Mayer, D | 1 |
| Rohlfing, T | 1 |
| Sullivan, EV | 2 |
| Pfefferbaum, A | 2 |
| Matsusue, E | 1 |
| Fink, JR | 1 |
| Rockhill, JK | 1 |
| Ogawa, T | 1 |
| Maravilla, KR | 1 |
| Qian, J | 1 |
| Herrera, JJ | 1 |
| Narayana, PA | 1 |
| Lombardo, F | 1 |
| Frijia, F | 1 |
| Bongioanni, P | 1 |
| Canapicchi, R | 1 |
| Minichilli, F | 1 |
| Bianchi, F | 1 |
| Hlavata, H | 1 |
| Rossi, B | 1 |
| Montanaro, D | 1 |
| Ciccarelli, O | 1 |
| Altmann, DR | 1 |
| McLean, MA | 2 |
| Wheeler-Kingshott, CA | 1 |
| Wimpey, K | 1 |
| Miller, DH | 3 |
| Thompson, AJ | 3 |
| Geurts, JJ | 1 |
| van Horssen, J | 1 |
| Georgoulopoulou, E | 1 |
| Gellera, C | 1 |
| Bragato, C | 1 |
| Sola, P | 1 |
| Chiari, A | 1 |
| Bernabei, C | 1 |
| Mandrioli, J | 1 |
| Portella, MJ | 1 |
| de Diego-Adeliño, J | 1 |
| Gómez-Ansón, B | 2 |
| Morgan-Ferrando, R | 1 |
| Vives, Y | 1 |
| Puigdemont, D | 1 |
| Pérez-Egea, R | 1 |
| Ruscalleda, J | 2 |
| Pérez, V | 1 |
| Davison, JE | 1 |
| Hendriksz, CJ | 1 |
| Sun, Y | 1 |
| Davies, NP | 1 |
| Gissen, P | 1 |
| Peet, AC | 1 |
| i Dali, C | 1 |
| Barton, NW | 1 |
| Fogh, J | 1 |
| Nair, N | 1 |
| Lund, AM | 1 |
| Zaaraoui, W | 1 |
| Reuter, F | 1 |
| Rico, A | 1 |
| Faivre, A | 1 |
| Crespy, L | 1 |
| Malikova, I | 1 |
| Soulier, E | 1 |
| Viout, P | 1 |
| Le Fur, Y | 1 |
| Confort-Gouny, S | 2 |
| Cozzone, PJ | 2 |
| Pelletier, J | 1 |
| Ranjeva, JP | 2 |
| Brugger, S | 1 |
| Davis, JM | 1 |
| Leucht, S | 1 |
| Stone, JM | 1 |
| Kim, JH | 1 |
| Choi, BS | 1 |
| Jung, C | 1 |
| Chang, Y | 1 |
| Fujita, K | 1 |
| Harada, M | 1 |
| Yuasa, T | 1 |
| Sasaki, M | 1 |
| Izumi, Y | 1 |
| Kaji, R | 1 |
| Messadi, A | 1 |
| Fekih-Mrissa, N | 1 |
| Zaouali, J | 1 |
| Layouni, S | 1 |
| Nsiri, B | 1 |
| Yedeas, M | 1 |
| Raies, A | 1 |
| Mrissa, R | 1 |
| Gritli, N | 1 |
| Walecki, J | 1 |
| Barcikowska, M | 1 |
| Ćwikła, JB | 1 |
| Gabryelewicz, T | 1 |
| Nicolasjilwan, M | 1 |
| Lopes, MB | 1 |
| Larner, J | 1 |
| Wintermark, M | 1 |
| Schiff, D | 1 |
| Yu, MK | 1 |
| Ye, W | 1 |
| Wang, WT | 1 |
| Lee, P | 1 |
| Yeh, HW | 1 |
| Smirnova, IV | 1 |
| Choi, IY | 2 |
| Uccelli, A | 1 |
| Milanese, M | 1 |
| Principato, MC | 1 |
| Morando, S | 1 |
| Bonifacino, T | 1 |
| Vergani, L | 1 |
| Giunti, D | 1 |
| Voci, A | 1 |
| Carminati, E | 1 |
| Giribaldi, F | 1 |
| Caponnetto, C | 1 |
| Bonanno, G | 1 |
| Wang, X | 1 |
| Zhang, A | 1 |
| Han, Y | 1 |
| Wang, P | 1 |
| Sun, H | 1 |
| Song, G | 1 |
| Dong, T | 1 |
| Yuan, Y | 1 |
| Yuan, X | 1 |
| Zhang, M | 1 |
| Xie, N | 1 |
| Zhang, H | 1 |
| Dong, H | 1 |
| Dong, W | 1 |
| Lim, TS | 1 |
| Hong, YH | 1 |
| Lee, HY | 1 |
| Choi, JY | 1 |
| Kim, HS | 1 |
| Moon, SY | 1 |
| Ferraioli, G | 1 |
| Tinelli, C | 1 |
| Malfitano, A | 1 |
| Dal Bello, B | 1 |
| Filice, G | 1 |
| Filice, C | 1 |
| Above, E | 1 |
| Barbarini, G | 1 |
| Brunetti, E | 1 |
| Calderon, W | 1 |
| Di Gregorio, M | 1 |
| Lissandrin, R | 1 |
| Ludovisi, S | 1 |
| Maiocchi, L | 1 |
| Michelone, G | 1 |
| Mondelli, M | 1 |
| Patruno, SF | 1 |
| Perretti, A | 1 |
| Poma, G | 1 |
| Sacchi, P | 1 |
| Zaramella, M | 1 |
| Zicchetti, M | 1 |
| Dogan, M | 1 |
| Dogan, DG | 1 |
| Kahraman, AS | 1 |
| Ozcan, O | 1 |
| Yakinci, C | 2 |
| Alkan, A | 2 |
| Zano, S | 1 |
| Wijayasinghe, YS | 1 |
| Malik, R | 1 |
| Smith, J | 1 |
| Viola, RE | 1 |
| Wang, PS | 1 |
| Chen, HC | 1 |
| Wu, HM | 1 |
| Lirng, JF | 1 |
| Wu, YT | 1 |
| Soong, BW | 1 |
| Pagonabarraga, J | 1 |
| Rotger, R | 1 |
| Llebaria, G | 1 |
| García-Sánchez, C | 1 |
| Pascual-Sedano, B | 1 |
| Gironell, A | 1 |
| Delfino, M | 1 |
| Kulisevsky, J | 1 |
| Sarzi, E | 1 |
| Angebault, C | 1 |
| Seveno, M | 1 |
| Gueguen, N | 1 |
| Chaix, B | 1 |
| Bielicki, G | 1 |
| Boddaert, N | 1 |
| Mausset-Bonnefont, AL | 1 |
| Cazevieille, C | 1 |
| Rigau, V | 1 |
| Renou, JP | 1 |
| Wang, J | 1 |
| Delettre, C | 1 |
| Brabet, P | 1 |
| Puel, JL | 1 |
| Hamel, CP | 1 |
| Reynier, P | 1 |
| Lenaers, G | 1 |
| Tonduti, D | 1 |
| Pichiecchio, A | 1 |
| Wolf, NI | 1 |
| Ariaudo, G | 1 |
| van der Knaap, MS | 2 |
| Bastianello, S | 1 |
| Balottin, U | 1 |
| Orcesi, S | 1 |
| Sarchielli, P | 1 |
| Presciutti, O | 1 |
| Tarducci, R | 2 |
| Gobbi, G | 2 |
| Alberti, A | 1 |
| Pelliccioli, GP | 2 |
| Chiarini, P | 1 |
| Gallai, V | 1 |
| Medeiros, RM | 1 |
| Morais, A | 1 |
| Vasconcelos, A | 1 |
| Costa, S | 1 |
| Pinto, D | 1 |
| Oliveira, J | 1 |
| Ferreira, P | 1 |
| Lopes, C | 1 |
| Bozzali, M | 1 |
| Kesavadas, C | 1 |
| Ghezzi, A | 1 |
| Grossman, RI | 4 |
| Scotti, G | 2 |
| Falini, A | 2 |
| Parry, A | 1 |
| Corkill, R | 1 |
| Blamire, AM | 2 |
| Palace, J | 1 |
| Narayanan, S | 7 |
| Arnold, D | 1 |
| Styles, P | 2 |
| Matthews, PM | 6 |
| Podell, M | 1 |
| Hadjiconstantinou, M | 1 |
| Smith, MA | 1 |
| Neff, NH | 1 |
| Brockmann, K | 1 |
| Dechent, P | 1 |
| Meins, M | 1 |
| Haupt, M | 1 |
| Sperner, J | 1 |
| Stephani, U | 1 |
| Frahm, J | 2 |
| Hanefeld, F | 1 |
| Zhai, P | 1 |
| Pagan, F | 1 |
| Statland, J | 1 |
| Butman, JA | 1 |
| Floeter, MK | 1 |
| Nicoli, F | 1 |
| Lefur, Y | 1 |
| Denis, B | 1 |
| Patel, SH | 1 |
| Inglese, M | 2 |
| Glosser, G | 1 |
| Kolson, DL | 2 |
| Sener, RN | 1 |
| Liu, YJ | 1 |
| Chen, CY | 1 |
| Chung, HW | 1 |
| Huang, IJ | 1 |
| Lee, CS | 1 |
| Chin, SC | 1 |
| Liou, M | 1 |
| Plass, JR | 1 |
| Mol, O | 1 |
| Heegsma, J | 1 |
| Geuken, M | 1 |
| de Bruin, J | 1 |
| Elling, G | 1 |
| Müller, M | 1 |
| Faber, KN | 1 |
| Jansen, PL | 1 |
| Mazurek, AA | 1 |
| Ge, Y | 2 |
| Markowitz, CE | 1 |
| Tzika, AA | 1 |
| Astrakas, LG | 1 |
| Zarifi, MK | 1 |
| Zurakowski, D | 1 |
| Poussaint, TY | 1 |
| Goumnerova, L | 1 |
| Tarbell, NJ | 1 |
| Black, PM | 1 |
| Fuller, RA | 1 |
| Westmoreland, SV | 1 |
| Ratai, E | 1 |
| Greco, JB | 1 |
| Kim, JP | 1 |
| He, J | 1 |
| Sehgal, PK | 1 |
| Halpern, E | 1 |
| Lackner, AA | 1 |
| Nagae-Poetscher, LM | 1 |
| Bibat, G | 1 |
| Philippart, M | 1 |
| Rosemberg, S | 1 |
| Fatemi, A | 1 |
| Lacerda, MT | 1 |
| Costa, MO | 1 |
| Kok, F | 1 |
| Costa Leite, C | 1 |
| Horská, A | 1 |
| Barker, PB | 1 |
| Naidu, S | 1 |
| Willemsen, MA | 1 |
| Van Der Graaf, M | 1 |
| Heerschap, A | 1 |
| Van Domburg, PH | 1 |
| Gabreëls, FJ | 1 |
| Rotteveel, JJ | 1 |
| Vyakarnam, A | 1 |
| Sidebottom, D | 1 |
| Murad, S | 1 |
| Underhill, JA | 1 |
| Easterbrook, PJ | 1 |
| Dalgleish, AG | 1 |
| Peakman, M | 1 |
| Kutlu, R | 1 |
| Sigirci, A | 1 |
| Aslan, M | 1 |
| Sarac, K | 1 |
| Demougeot, C | 1 |
| Marie, C | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Linnankivi, T | 1 |
| Lundbom, N | 2 |
| Autti, T | 1 |
| Häkkinen, AM | 1 |
| Koillinen, H | 1 |
| Kuusi, T | 1 |
| Lönnqvist, T | 1 |
| Sainio, K | 1 |
| Valanne, L | 1 |
| Aärimaa, T | 1 |
| Pihko, H | 1 |
| Chan, AA | 1 |
| Pirzkall, A | 2 |
| Chang, SM | 1 |
| Verhey, LJ | 1 |
| Larson, D | 1 |
| McDermott, MW | 1 |
| Dillon, WP | 2 |
| Katz-Brull, R | 1 |
| Lenkinski, RE | 1 |
| Du Pasquier, RA | 1 |
| Koralnik, IJ | 1 |
| von Kienlin, M | 1 |
| Künnecke, B | 1 |
| Metzger, F | 1 |
| Steiner, G | 1 |
| Richards, JG | 1 |
| Ozmen, L | 1 |
| Jacobsen, H | 1 |
| Loetscher, H | 1 |
| Ashwal, S | 1 |
| Holshouser, B | 1 |
| Tong, K | 1 |
| Serna, T | 1 |
| Osterdock, R | 1 |
| Gross, M | 1 |
| Kido, D | 1 |
| Raizer, JJ | 1 |
| Koutcher, JA | 2 |
| Abrey, LE | 1 |
| Panageas, KS | 1 |
| DeAngelis, LM | 1 |
| Lis, E | 1 |
| Xu, S | 1 |
| Zakian, KL | 1 |
| Tkác, I | 1 |
| Charnas, LR | 1 |
| Bjoraker, KJ | 1 |
| Shapiro, EG | 1 |
| Gruetter, R | 1 |
| Biernacki, K | 1 |
| Antel, JP | 3 |
| Blain, M | 1 |
| Prat, A | 1 |
| Sastre-Garriga, J | 1 |
| Ingle, GT | 1 |
| Chard, DT | 1 |
| Ramió-Torrentà, L | 1 |
| Laprie, A | 1 |
| Haas-Kogan, DA | 1 |
| Cha, S | 1 |
| Banerjee, A | 1 |
| Le, TP | 1 |
| Lu, Y | 1 |
| Nelson, S | 1 |
| McKnight, TR | 1 |
| Kroner, A | 1 |
| Vogel, F | 1 |
| Kolb-Mäurer, A | 1 |
| Kruse, N | 1 |
| Toyka, KV | 1 |
| Hemmer, B | 1 |
| Rieckmann, P | 1 |
| Mäurer, M | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Taylor, JR | 1 |
| Brownlow, N | 1 |
| Domin, J | 1 |
| Dibb, NJ | 1 |
| Ohtsu, S | 1 |
| Takubo, N | 1 |
| Kazahari, M | 1 |
| Nomoto, K | 1 |
| Yokota, F | 1 |
| Kikuchi, N | 1 |
| Koike, A | 1 |
| Matsuura, N | 1 |
| Suzuki, A | 1 |
| Ogura, T | 1 |
| Esumi, H | 1 |
| Marino, S | 1 |
| Borsini, W | 1 |
| Buchner, S | 1 |
| Mortilla, M | 3 |
| Bramanti, P | 1 |
| Federico, A | 3 |
| Kato, Z | 2 |
| Asano, T | 1 |
| Kondo, N | 2 |
| Morshed, NM | 1 |
| Sobhan, MA | 1 |
| Nahar, JS | 1 |
| Keramat Ali, SM | 1 |
| Shams, M | 1 |
| Lichy, MP | 1 |
| Bachert, P | 1 |
| Hamprecht, F | 1 |
| Weber, MA | 1 |
| Debus, J | 1 |
| Schulz-Ertner, D | 1 |
| Schlemmer, HP | 1 |
| Kauczor, HU | 1 |
| Gunter, J | 1 |
| Reyes, D | 1 |
| Shiung, M | 1 |
| Smith, GE | 2 |
| Ivnik, RJ | 2 |
| Tangalos, EG | 2 |
| Appenzeller, S | 1 |
| Costallat, LT | 1 |
| Li, LM | 1 |
| Cendes, F | 2 |
| Naini, A | 1 |
| Mehrazin, M | 1 |
| Lu, J | 1 |
| Gordon, P | 1 |
| Mitsumoto, H | 1 |
| Niessen, HG | 1 |
| Debska-Vielhaber, G | 1 |
| Sander, K | 1 |
| Angenstein, F | 1 |
| Ludolph, AC | 1 |
| Hilfert, L | 1 |
| Willker, W | 1 |
| Leibfritz, D | 1 |
| Heinze, HJ | 1 |
| Kunz, WS | 1 |
| Vielhaber, S | 1 |
| Anlar, B | 1 |
| Broom, KA | 1 |
| Anthony, DC | 1 |
| Lowe, JP | 1 |
| Griffin, JL | 1 |
| Scott, H | 1 |
| Perry, VH | 1 |
| Sibson, NR | 1 |
| Mathew, R | 1 |
| Kongara, S | 1 |
| Beaudoin, B | 1 |
| Karp, CM | 1 |
| Bray, K | 1 |
| Degenhardt, K | 1 |
| Chen, G | 1 |
| Jin, S | 1 |
| White, E | 1 |
| Pascual, JM | 1 |
| Solivera, J | 1 |
| Prieto, R | 1 |
| Barrios, L | 1 |
| López-Larrubia, P | 1 |
| Cerdán, S | 1 |
| Roda, JM | 1 |
| Pascual, AM | 1 |
| Martínez-Bisbal, MC | 1 |
| Boscá, I | 1 |
| Valero, C | 1 |
| Coret, F | 1 |
| Martínez-Granados, B | 1 |
| Marti-Bonmati, L | 1 |
| Mir, A | 1 |
| Celda, B | 1 |
| Casanova, B | 1 |
| Worgall, S | 1 |
| Kekatpure, MV | 1 |
| Heier, L | 1 |
| Ballon, D | 2 |
| Dyke, JP | 1 |
| Shungu, D | 1 |
| Mao, X | 1 |
| Kosofsky, B | 1 |
| Kaplitt, MG | 1 |
| Souweidane, MM | 1 |
| Sondhi, D | 1 |
| Hackett, NR | 1 |
| Hollmann, C | 1 |
| Crystal, RG | 1 |
| Alimenti, A | 1 |
| Delavelle, J | 1 |
| Lazeyras, F | 1 |
| Yilmaz, H | 1 |
| Dietrich, PY | 1 |
| de Tribolet, N | 1 |
| Lövblad, KO | 1 |
| Jansen, AC | 1 |
| Cao, H | 1 |
| Kaplan, P | 1 |
| Silver, K | 2 |
| Leonard, G | 1 |
| De Meirleir, L | 1 |
| Lissens, W | 1 |
| Liebaers, I | 1 |
| Veilleux, M | 1 |
| Andermann, F | 2 |
| Hegele, RA | 1 |
| Andermann, E | 1 |
| Barkhatova, VP | 1 |
| Panteleeva, EA | 1 |
| Alferova, VP | 1 |
| Rebrova, OIu | 1 |
| Niiazbekova, AS | 1 |
| Zavalishin, IA | 1 |
| Basurto-Islas, G | 1 |
| Luna-Muñoz, J | 1 |
| Guillozet-Bongaarts, AL | 1 |
| Binder, LI | 1 |
| Mena, R | 1 |
| García-Sierra, F | 1 |
| Azevedo, D | 1 |
| Tatsch, M | 1 |
| Hototian, SR | 1 |
| Bazzarella, MC | 1 |
| Castro, CC | 1 |
| Bottino, CM | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Jodrell, DI | 1 |
| Oster, W | 1 |
| Kerr, DJ | 1 |
| Canney, PA | 1 |
| Yosef, H | 1 |
| Steward, WP | 1 |
| Kaye, SB | 1 |
| Cassidy, J | 1 |
| Alfieri, AA | 1 |
| Tsai, JC | 1 |
| Matei, C | 1 |
| Stolfi, RL | 1 |
| Martin, DS | 1 |
| Fu, L | 2 |
| Wolfson, C | 1 |
| Worsley, KJ | 1 |
| Collins, DL | 1 |
| Tedeschi, G | 1 |
| Raman, R | 1 |
| Bonavita, S | 1 |
| Duyn, JH | 1 |
| Alger, JR | 1 |
| Di Chiro, G | 1 |
| Wald, LL | 1 |
| Day, MR | 1 |
| Noworolski, SE | 1 |
| Henry, RG | 1 |
| Huhn, SL | 1 |
| Chang, S | 1 |
| Prados, MD | 1 |
| Sneed, PK | 1 |
| Larson, DA | 1 |
| Wara, WM | 1 |
| McDermott, M | 1 |
| Gutin, PH | 1 |
| Vigneron, DB | 1 |
| Jones, HC | 1 |
| Harris, NG | 1 |
| Rocca, JR | 1 |
| Andersohn, RW | 1 |
| Yamamoto, A | 1 |
| Takagi, H | 1 |
| Kitamura, D | 1 |
| Tatsuoka, H | 1 |
| Nakano, H | 1 |
| Kawano, H | 1 |
| Kuroyanagi, H | 1 |
| Yahagi, Y | 1 |
| Kobayashi, S | 1 |
| Koizumi, K | 1 |
| Sakai, T | 1 |
| Saito, K | 1 |
| Chiba, T | 1 |
| Kawamura, K | 1 |
| Suzuki, K | 1 |
| Mori, H | 1 |
| Shirasawa, T | 1 |
| Calabrese, G | 1 |
| Origgi, D | 1 |
| Lipari, S | 1 |
| Colombo, B | 1 |
| Kruse, B | 1 |
| Pouwels, PJ | 1 |
| Christen, HJ | 1 |
| Hanefeld, FA | 1 |
| Stanley, J | 1 |
| Francis, GS | 2 |
| Doraiswamy, PM | 1 |
| Charles, HC | 1 |
| Krishnan, KR | 1 |
| Terakawa, H | 1 |
| Abe, K | 1 |
| Watanabe, Y | 1 |
| Nakamura, M | 1 |
| Fujita, N | 1 |
| Hirabuki, N | 1 |
| Yanagihara, T | 1 |
| Cashman, NR | 1 |
| Federico, F | 1 |
| Simone, IL | 1 |
| Lucivero, V | 1 |
| Mezzapesa, DM | 1 |
| de Mari, M | 1 |
| Lamberti, P | 1 |
| Petruzzellis, M | 1 |
| Ferrari, E | 1 |
| Davie, CA | 1 |
| Silver, NC | 1 |
| Barker, GJ | 1 |
| Tofts, PS | 1 |
| McDonald, WI | 1 |
| Catalaa, I | 1 |
| Mannon, LJ | 1 |
| Yoo, J | 1 |
| Robinson, RA | 1 |
| Bendszus, M | 1 |
| Warmuth-Metz, M | 1 |
| Klein, R | 1 |
| Burger, R | 1 |
| Schichor, C | 1 |
| Tonn, JC | 1 |
| Solymosi, L | 1 |
| Cucurella, MG | 1 |
| Río, J | 1 |
| Pedraza, S | 1 |
| Tintoré, MM | 1 |
| Alonso, J | 1 |
| Adalsteinsson, E | 1 |
| Kleinhans, N | 1 |
| Spielman, DM | 1 |
| Xu, YC | 1 |
| Campeau, NG | 1 |
| Kokmen, E | 1 |
| Mizuno, S | 1 |
| Takahashi, Y | 1 |
| Goto, H | 1 |
| Hoshi, H | 1 |
| Arnaoutelis, R | 1 |
| Tartaglia, MC | 1 |
| Guidi, L | 1 |
| Holm, IE | 1 |
| Abelskov, K | 1 |
| Bojsen-Møller, M | 1 |
| Nielsen, AL | 1 |
| Jørgensen, AL | 1 |
| Pohl, C | 1 |
| Block, W | 1 |
| Karitzky, J | 1 |
| Träber, F | 1 |
| Schmidt, S | 1 |
| Grothe, C | 1 |
| Lamerichs, R | 1 |
| Schild, H | 1 |
| Klockgether, T | 1 |
| Malloy, CR | 1 |
| Balestri, P | 1 |
| Dotti, MT | 1 |
| Grosso, S | 1 |
| Morgese, G | 1 |
| Thebo, JS | 1 |
| Senagore, AJ | 1 |
| Krygier, S | 1 |
| Luchtefeld, MA | 1 |
| Pereira, AC | 1 |
| Cuoco, MA | 1 |
| Mota, GF | 1 |
| da Silva, FF | 1 |
| Freitas, HF | 1 |
| Bocchi, EA | 1 |
| Soler, JM | 1 |
| Mansur, AJ | 1 |
| Krieger, JE | 1 |
| Kobayashi, M | 1 |
| Takayama, H | 1 |
| Suga, S | 1 |
| Mihara, B | 1 |
| Bak, MI | 1 |
| Domzał-Stryga, A | 1 |
| Królicki, L | 1 |
| Kwieciński, H | 1 |
| Suhy, J | 1 |
| Miller, RG | 1 |
| Rule, R | 1 |
| Schuff, N | 1 |
| Licht, J | 1 |
| Dronsky, V | 1 |
| Gelinas, D | 1 |
| Maudsley, AA | 1 |
| Weiner, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis[NCT02405182] | 145 participants (Actual) | Observational | 2014-09-30 | Completed | |||
| Glutamate, Brain Connectivity and Duration of Untreated Psychosis[NCT02034253] | 134 participants (Actual) | Observational | 2014-01-31 | Completed | |||
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| Phase 1/2, Open Label, Sequential Cohort Study of a Single Intracranial Dose of AVASPA Gene Therapy for Treatment of Children With Typical Canavan Disease[NCT04833907] | Phase 1/Phase 2 | 24 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| OxCarbazepine as a Neuroprotective Agent in MS: A Phase 2a Trial[NCT02104661] | Phase 2 | 30 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428] | 71 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206] | 12 participants (Anticipated) | Observational | 2020-12-31 | Not yet recruiting | |||
| A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.[NCT01801709] | Phase 1/Phase 2 | 5 participants (Anticipated) | Interventional | 2014-06-30 | Active, not recruiting | ||
| Sjogren-Larsson Syndrome: A Longitudinal Study of Natural History, Clinical Variation and Evaluation of Biochemical Markers[NCT01971957] | 20 participants (Actual) | Observational [Patient Registry] | 2013-04-01 | Completed | |||
| A Phase II Study of the Combination of Gemcitabine and Imatinib Mesylate in Pemetrexed-pretreated Patients With Malignant Pleural Mesothelioma[NCT02303899] | Phase 2 | 22 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| An Open-label, Non-randomized, Phase I/II Study of Autologous Bone Marrow-Derived Mononuclear Stem Cells (BM-MNC) and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS[NCT02587806] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02587715] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02418325] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Terminated (stopped due to Lack of funding) | ||
| Genotype - Phenotype Correlations of Late Infantile Neuronal Ceroid Lipofuscinosis[NCT00151268] | 18 participants (Actual) | Observational | 2004-03-31 | Completed | |||
| Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease[NCT03862274] | 30 participants (Anticipated) | Observational | 2018-12-01 | Enrolling by invitation | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
11 reviews available for aspartic acid and Disease Exacerbation
| Article | Year |
|---|---|
Fuelling cancer cells.
Topics: Asparagine; Aspartic Acid; Disease Progression; Female; Humans; Lactic Acid; Male; Neoplasms; Oxygen | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Proton magnetic resonance spectroscopy and illness stage in schizophrenia--a systematic review and meta-analysis.
Topics: Aspartic Acid; Data Interpretation, Statistical; Disease Progression; Frontal Lobe; Humans; Magnetic | 2011 |
N-acetylaspartate: a literature review of animal research on brain ischaemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal | 2004 |
Magnetic resonance spectroscopy in the evaluation of central nervous system manifestations of systemic lupus erythematosus.
Topics: Aspartic Acid; Brain; Central Nervous System; Creatine; Disease Progression; Humans; Lupus Vasculiti | 2006 |
Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy.
Topics: Animals; Aspartic Acid; Brain; Disease Progression; Epilepsy; Epilepsy, Tonic-Clonic; Mice; Mice, In | 1998 |
Biological markers in the diagnosis and treatment of ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Progression; Elec | 1999 |
Imaging axonal damage in multiple sclerosis by means of MR spectroscopy.
Topics: Animals; Aspartic Acid; Axons; Central Nervous System; Disability Evaluation; Disease Progression; H | 2000 |
Proton MR spectroscopy in multiple sclerosis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Disability Evaluation; Disease Progression; Energy Metaboli | 2000 |
Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution.
Topics: Aspartic Acid; Axons; Brain; Disability Evaluation; Disease Progression; Humans; Magnetic Resonance | 2001 |
[Proton MR spectroscopy studies of the brain in ALS patients].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Disease Progression; Female; Front | 2001 |
12 trials available for aspartic acid and Disease Exacerbation
| Article | Year |
|---|---|
NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study.
Topics: Adult; Amiloride; Aspartic Acid; Biomarkers; Child, Preschool; Cohort Studies; Cross-Sectional Studi | 2020 |
1H-magnetic resonance spectroscopy in diffuse and focal cervical cord lesions in multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cervical Vertebrae; Creatine; Cross-Sectional Studies; D | 2013 |
Randomized trial of erhuangfang for relapsing multiple sclerosis.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Aspartic Acid; Brain; Creatine; Disability Evaluation; | 2015 |
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis | 2008 |
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusio | 2009 |
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy.
Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Cognition; Creatine; Disease Progressio | 2010 |
Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Body Water; Brain Chemistry; Cohort Studies; Creatine; Disease Progress | 2003 |
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study.
Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffu | 2003 |
Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Choline | 2005 |
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disord | 2008 |
A phase I-II study of N-(phosphonacetyl)-L-aspartic acid (PALA) added to 5-fluorouracil and folinic acid in advanced colorectal cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neop | 1994 |
Longitudinal changes of metabolites in frontal lobes after hemorrhagic stroke of basal ganglia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Basal Ganglia Hemorrhage; Creatine; Disease Progression; Fem | 2001 |
162 other studies available for aspartic acid and Disease Exacerbation
| Article | Year |
|---|---|
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; | 2019 |
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements; | 2020 |
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progressio | 2021 |
Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Cross-Sectional Studies; Disease Progression; Female | 2017 |
ATP1A3 mutant patient with alternating hemiplegia of childhood and brain spectroscopic abnormalities.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Disease Progression; Hemiplegia; Humans; Magn | 2017 |
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Diseas | 2017 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.
Topics: Activities of Daily Living; Adult; Aged; Aspartic Acid; Ataxins; Brain; Brain Diseases, Metabolic; C | 2018 |
D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.
Topics: alpha-Synuclein; Animals; Aspartic Acid; Brain Stem; Disease Progression; Endoplasmic Reticulum Stre | 2018 |
Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Cell Respiratio | 2018 |
Increased glutamate and deep brain atrophy can predict the severity of multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonanc | 2019 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Diseas | 2018 |
Progress of Brain Amyloid Deposition in Familial Alzheimer's Disease with Taiwan D678H APP Mutation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P | 2018 |
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression | 2019 |
Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Case-Control Studies; Diabetes Mellitus, Type 1; Diabe | 2019 |
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2013 |
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic | 2013 |
Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity.
Topics: Antibodies; Arthritis, Rheumatoid; Aspartic Acid; Autoantibodies; Calcium; Cross Reactions; Disease | 2013 |
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Chronic Disease; Disease Progression; Female; Glutamic Acid; Gluta | 2014 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Hippocampal neurochemical changes in senescent mice induced with chronic injection of D-galactose and NaNO₂: an in vitro high-resolution NMR spectroscopy study at 9.4T.
Topics: Amyloid; Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Cell Proliferation; Congo Red; Disease | 2014 |
Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Creatine; Disability Evaluation; Disease Progression; Female; | 2014 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; De | 2014 |
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Case-Control Studies; Disability Evaluation; Disease Prog | 2014 |
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C | 2014 |
N-acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Biomarkers; Disability Evaluation; Disease Progression; Female; Follow- | 2014 |
Hepatic Fibrosis Progression in HIV-Hepatitis C Virus Co-Infection--The Effect of Sex on Risk of Significant Fibrosis Measured by Aspartate-to-Platelet Ratio Index.
Topics: Adult; Antiretroviral Therapy, Highly Active; Aspartate Aminotransferases; Aspartic Acid; Biomarkers | 2015 |
[Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy].
Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; | 2015 |
KIT D816V-mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression.
Topics: Adult; Amino Acid Substitution; Aspartic Acid; Bone Marrow Cells; Cell Lineage; Disease Progression; | 2016 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
MRI/MRS as a surrogate marker for clinical progression in GM1 gangliosidosis.
Topics: Adolescent; Age of Onset; Aspartic Acid; Atrophy; beta-Galactosidase; Cerebellum; Cerebrum; Child; C | 2016 |
Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study.
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Disease P | 2016 |
Normalisation of brain spectroscopy findings in Niemann-Pick disease type C patients treated with miglustat.
Topics: 1-Deoxynojirimycin; Adolescent; Adult; Aspartic Acid; Brain; Choline; Disability Evaluation; Disease | 2016 |
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child, | 2016 |
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.
Topics: Adenoma; Adult; Aged; Animals; Aspartic Acid; Biomarkers, Tumor; Carcinoma; Cell Line, Tumor; Cell M | 2016 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
The association between retinal nerve fibre layer thickness and N-acetyl aspartate levels in multiple sclerosis brain normal-appearing white matter: a longitudinal study using magnetic resonance spectroscopy and optical coherence tomography.
Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Humans; Longitudinal Studies; Magne | 2016 |
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; H | 2016 |
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
Topics: Amidohydrolases; Animals; Aspartic Acid; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcri | 2016 |
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I | 2017 |
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; Calcium-Calmodulin-D | 2008 |
Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.
Topics: Age Factors; Amidohydrolases; Animals; Animals, Newborn; Aspartic Acid; Axons; Behavior, Animal; Can | 2008 |
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Dise | 2008 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel | 2008 |
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease.
Topics: Aged; alpha-Macroglobulins; Alzheimer Disease; Aspartic Acid; Biomarkers; Complement Factor H; Disea | 2008 |
The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia.
Topics: Agnosia; Aspartic Acid; Atrophy; Brain; Brain Mapping; Disease Progression; Energy Metabolism; Femal | 2009 |
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease P | 2010 |
Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.
Topics: Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Child, Preschool; Choline; Corpus Callosum; Cr | 2008 |
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis.
Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic | 2009 |
Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Disease Progressi | 2009 |
Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; CD4-CD8 Ratio; Disease Progression; | 2009 |
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Atrophy; Biomarkers; Brain; Cerebrovascular Disorders; Cogni | 2009 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Biomarkers; Brain; Brain Chemistry; Cell Survival; Cross-Sectional Stud | 2009 |
A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages.
Topics: Adolescent; Aspartic Acid; Brain; Child; Choline; Creatine; Disease Progression; Down-Regulation; El | 2010 |
Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis.
Topics: Aspartic Acid; Bone Marrow; Brain; Child; Choline; Diagnosis, Differential; Disease Progression; Fat | 2009 |
Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Amino Acid Substitution; Aspartic Acid; Case- | 2010 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image | 2009 |
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr | 2010 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm | 2010 |
Spinal cord repair in MS: does mitochondrial metabolism play a role?
Topics: Adult; Aspartic Acid; Axons; Cervical Vertebrae; Disease Progression; Female; Follow-Up Studies; Hum | 2010 |
The brake on neurodegeneration: Increased mitochondrial metabolism in the injured MS spinal cord.
Topics: Aspartic Acid; Cervical Vertebrae; Disease Progression; Female; Humans; Magnetic Resonance Spectrosc | 2010 |
A novel SOD1 mutation in a young amyotrophic lateral sclerosis patient with a very slowly progressive clinical course.
Topics: Adult; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Disease Progr | 2010 |
Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients.
Topics: Adult; Age of Onset; Aspartic Acid; Choline; Chronic Disease; Depressive Disorder, Major; Disease Pr | 2011 |
Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome).
Topics: Adolescent; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Case-Control Studies; Child; Child, Pre | 2010 |
Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration.
Topics: Adult; Aspartic Acid; Cognition Disorders; Disease Progression; Female; Humans; Magnetic Resonance S | 2011 |
Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course.
Topics: Aged; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Creutzfeldt-Jakob Syndrome; Diffusion Mag | 2011 |
Temporal evolution of sporadic Creutzfeldt-Jakob disease monitored by 3-Tesla MR spectroscopy.
Topics: Aged; Aspartic Acid; Choline; Creutzfeldt-Jakob Syndrome; Disease Progression; Female; Humans; Magne | 2011 |
[Implication of platelet-activating factor receptor A224D mutation in susceptibility to relapsing-remitting multiple sclerosis: A Tunisian population study].
Topics: Adult; Alanine; Amino Acid Substitution; Aspartic Acid; Disease Progression; Female; Genetic Associa | 2012 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; | 2011 |
Subependymal seeding of low-grade oligodendroglial neoplasms: a case series.
Topics: Adult; Aspartic Acid; Creatine; Disease Progression; Ependyma; Fourth Ventricle; Glioma; Humans; Iso | 2012 |
The imaging diagnosis and prognosis assessment of patients with midbrain injury in the acute phase of craniocerebral injury.
Topics: Adolescent; Adult; Aspartic Acid; Child; Choline; Craniocerebral Trauma; Creatine; Disease Progressi | 2012 |
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T.
Topics: Acute Disease; Algorithms; Animals; Aspartic Acid; Biological Transport, Active; Blood Glucose; Bloo | 2012 |
Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Movement; Central Nervous System; Diseas | 2012 |
Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease.
Topics: Adult; Alanine; Aspartic Acid; Biomarkers; Chromatography, High Pressure Liquid; Disease Progression | 2012 |
Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Disease Pr | 2012 |
Performance of real-time strain elastography, transient elastography, and aspartate-to-platelet ratio index in the assessment of fibrosis in chronic hepatitis C.
Topics: Adult; Area Under Curve; Aspartic Acid; Biopsy; Blood Platelets; Disease Progression; Elasticity Ima | 2012 |
A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Adolescent; Anticonvulsants; Aspartic Acid; Biomarkers; Brain; Child; Creatinine; Disease Progressio | 2012 |
Relationship between enzyme properties and disease progression in Canavan disease.
Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Catalysis; Disease Progression; Humans; Muta | 2013 |
Association between proton magnetic resonance spectroscopy measurements and CAG repeat number in patients with spinocerebellar ataxias 2, 3, or 6.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Case-Control Studies; Cerebellum; Creatine; Disease Progre | 2012 |
Spectroscopic changes associated with mild cognitive impairment and dementia in Parkinson's disease.
Topics: Aged, 80 and over; Aspartic Acid; Brain Chemistry; Cognition; Cognitive Dysfunction; Data Interpreta | 2012 |
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution | 2012 |
Novel hypomyelinating leukoencephalopathy affecting early myelinating structures: clinical course in two brothers.
Topics: Aspartic Acid; Cerebellum; Child; Child, Preschool; Disease Progression; Humans; Leukoencephalopathi | 2013 |
Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spe | 2002 |
Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7.
Topics: Aged; Aspartic Acid; Bone Neoplasms; Disease Progression; Exons; Genotype; Glutamic Acid; Humans; Lo | 2002 |
Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic | 2003 |
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus S | 2003 |
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr | 2003 |
Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes?
Topics: Adult; Aspartic Acid; Atrophy; Brain Stem; Choline; Creatinine; Disease Progression; Evoked Potentia | 2003 |
Whole-brain N-acetylaspartate level and cognitive performance in HIV infection.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Atrophy; Brain; Disease Progression; Energy Metabolism; | 2003 |
Pantothenate kinase-associated neurodegeneration: MR imaging, proton MR spectroscopy, and diffusion MR imaging findings.
Topics: Adolescent; Aspartic Acid; Brain; Cerebellar Nuclei; Choline; Creatine; Diagnosis, Differential; Dif | 2003 |
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Co | 2003 |
A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Aspartic Acid; ATP Binding Cassette Transpo | 2004 |
Reduced N-acetylaspartate levels and cognitive decline.
Topics: Alleles; Apolipoproteins E; Aspartic Acid; Brain Chemistry; Cognition Disorders; Disease Progression | 2004 |
Neuronal cell injury precedes brain atrophy in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Disease Progression; Female; Humans; Magnetic | 2004 |
Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Disea | 2004 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
Leukoencephalopathy, cerebral calcifications, and cysts: new observations.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; C | 2004 |
MR imaging and proton MR spectroscopic studies in Sjögren-Larsson syndrome: characterization of the leukoencephalopathy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Ventricles; Child; Child, Preschool; Choline; Crea | 2004 |
Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection.
Topics: Alleles; Aspartic Acid; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Disease Progression; Femal | 2004 |
Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings.
Topics: Aspartic Acid; Brain; Cerebral Cortex; Child, Preschool; Choline; Creatine; Diagnosis, Differential; | 2004 |
Five new cases of a recently described leukoencephalopathy with high brain lactate.
Topics: Adolescent; Aspartic Acid; Ataxia; Brain Chemistry; Brain Diseases, Metabolic; Brain Stem; Central N | 2004 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor | 2004 |
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy.
Topics: Adult; Aspartic Acid; Cerebellum; Cerebral Cortex; Choline; Creatine; Disease Progression; Female; H | 2004 |
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; | 2005 |
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Com | 2004 |
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous Syst | 2005 |
Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients.
Topics: Adolescent; Adrenoleukodystrophy; Aspartic Acid; Brain Chemistry; Child; Child, Preschool; Creatine; | 2005 |
Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis.
Topics: Adult; Aspartic Acid; Astrocytes; Atrophy; CD3 Complex; Cell Communication; Cells, Cultured; Central | 2005 |
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression | 2005 |
Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on disease course of multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Cells, Cultured; Cytokines; Disease Progr | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Benzamides; Disease Progression; Dose-Response Relati | 2006 |
Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.
Topics: Age of Onset; Arginine; Asian People; Aspartic Acid; Autoantibodies; Case-Control Studies; Child; Ch | 2005 |
NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.
Topics: Amino Acid Sequence; Aspartic Acid; Calcium; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; | 2006 |
Diffuse structural and metabolic brain changes in Fabry disease.
Topics: Adult; alpha-Galactosidase; Aspartic Acid; Axons; Brain; Brain Chemistry; Disease Progression; DNA; | 2006 |
Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis.
Topics: Adolescent; Antiviral Agents; Artifacts; Aspartic Acid; Choline; Disease Progression; Dominance, Cer | 2006 |
Excitatory aminoacid neurotransmitters in schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Bangladesh; Case-Control Studies; Disease Progression; Excitatory | 2005 |
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined | 2006 |
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition | 2007 |
Identification of a novel D109Y mutation in Cu/Zn superoxide dismutase (sod1) gene associated with amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Catalytic Doma | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Mo | 2007 |
Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS.
Topics: Aspartic Acid; Brain Chemistry; Confounding Factors, Epidemiologic; Disease Progression; Humans; Ino | 2007 |
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.
Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models, | 2007 |
Autophagy suppresses tumor progression by limiting chromosomal instability.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Autophagy; Autophagy-Related Prote | 2007 |
Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffuse Axona | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Topics: Adolescent; Adult; Aspartic Acid; Disease Progression; DNA Mutational Analysis; Family Health; Femal | 2007 |
[Neurotransmission mechanism of movement disorders in multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Disease Progression; Female; Glutamic Acid; Humans; Male; Middle A | 2007 |
Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E4; Aspartic Acid; Brain; Disease Progr | 2008 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
Imaging of axonal damage in vivo in Rasmussen's syndrome.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Child; Chronic Disease; Creatine; Disease Progression; E | 1995 |
Evaluation of chemotherapy and radiation enhancement and 31P NMR spectral changes induced by biochemical modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Di | 1997 |
Statistics for investigation of multimodal MR imaging data and an application to multiple sclerosis patients.
Topics: Aspartic Acid; Brain; Creatine; Disease Progression; Humans; Image Interpretation, Computer-Assisted | 1996 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro | 1997 |
Progressive changes in cortical metabolites at three stages of infantile hydrocephalus studied by in vitro NMR spectroscopy.
Topics: Age Factors; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Case-Control Studies; Cell M | 1997 |
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Huma | 1998 |
Proton magnetic resonance spectroscopy of linear nevus sebaceus syndrome.
Topics: Aspartic Acid; Brain Chemistry; Cerebral Cortex; Child, Preschool; Choline; Creatine; Disease Progre | 1998 |
Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study.
Topics: Aspartic Acid; Axons; Brain; Creatine; Disability Evaluation; Disease Progression; Humans; Longitudi | 1998 |
Prediction of cognitive decline in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition; Disease Progression; Humans; Mag | 1998 |
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro | 1999 |
Usefulness of proton magnetic resonance spectroscopy in differentiating parkinsonian syndromes.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Diagnosis, Differential; Disease Progression; | 1999 |
Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup?
Topics: Aspartic Acid; Axons; Cerebral Cortex; Chronic Disease; Demyelinating Diseases; Disease Progression; | 1999 |
Total brain N-acetylaspartate: a new measure of disease load in MS.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Cell Survival; Disease Progression; Female; Hum | 2000 |
H-ras gene mutations in salivary gland mucoepidermoid carcinomas.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Carcinoma, Mucoepidermoid; Child | 2000 |
MR spectroscopy in gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Choline; Creatine; Di | 2000 |
Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic | 2000 |
Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Disease Progression; Female; Human | 2000 |
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorde | 2000 |
Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
Topics: Adult; Age Factors; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Disease | 2000 |
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.
Topics: Adult; Aspartic Acid; Atrophy; Axons; Brain; Chromatography, High Pressure Liquid; Creatine; Disabil | 2001 |
Creutzfeldt-Jakob disease segregating in a three generation Danish family.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alleles; Asparagine; Aspartic Acid; Creutzfeldt-Jakob | 2001 |
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; | 2001 |
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu | 2001 |
Severe metabolic abnormalities in the white matter of patients with vacuolating megalencephalic leukoencephalopathy with subcortical cysts. A proton MR spectroscopic imaging study.
Topics: Adolescent; Adult; Aspartic Acid; Creatine; Cysts; Dementia, Vascular; Disease Progression; Female; | 2001 |
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Topics: Aspartic Acid; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Genes, ras; Glyci | 2001 |
Hemochromatosis gene variants in patients with cardiomyopathy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Cardiomyopathies; Cysteine; Disease Progression; Female; Gen | 2001 |
Editorial commentary to Narayanan et al. Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b.
Topics: Adjuvants, Immunologic; Aspartic Acid; Clinical Trials as Topic; Diffuse Axonal Injury; Disease Prog | 2001 |
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans | 2002 |