aspartic acid has been researched along with Diabetes Mellitus, Type 2 in 51 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glycogen levels were also lower in this region." | 5.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "Older adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density." | 1.91 | Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study. ( Bain, J; Colón-Emeric, C; Ilkayeva, O; Lee, RH; Muehlbauer, M; Pieper, C; Wixted, D, 2023) |
| "The hypercalcemia was specifically induced by calcium L-aspartate and eldecalcitol." | 1.91 | A Case of Milk-Alkali Syndrome Caused by Diuretic-Induced Alkalosis and Polypharmacy. ( Goda, K; Kenzaka, T; Mizutani, N, 2023) |
| "Children of mothers with gestational diabetes mellitus (GDM) are more prone to acquire type 2 diabetes and obesity as adults." | 1.91 | Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus. ( Feng, Y; Jie, Q; Liang, W; Qin, J; Wu, W; Yang, D; Zhi, X, 2023) |
| "The number of patients with diabetic neuropathic pain (DNP) continues to increase, but available treatments are limited." | 1.72 | Reactive Oxygen Species Contributes to Type 2 Diabetic Neuropathic Pain via the Thioredoxin-Interacting Protein-NOD-Like Receptor Protein 3- N -Methyl-D-Aspartic Acid Receptor 2B Pathway. ( Cao, H; Li, J; Li, X; Luo, GH; Wang, JW; Wei, N; Wu, SS; Ye, XY; Zhang, ZH, 2022) |
| "Eighty six patients with Type 2 diabetes mellitus (T2DM) were enrolled for this study." | 1.43 | [Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus]. ( Niu, H; Shen, J; Shi, X; Wang, R; Wang, S; Wu, J; Yang, H; Zhang, Y; Zhou, S, 2016) |
| "The metabolic alterations of type 2 diabetes are associated with protection against IR injury at onset but detrimental effects in late diabetes mellitus consistent with progressive dysfunction of glucose oxidation." | 1.39 | Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. ( Birkler, RI; Bøtker, HE; Dalgas, C; Johannsen, M; Løfgren, B; Povlsen, JA; Støttrup, NB, 2013) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| "In the type 2 diabetes model GABA levels were increased suggesting that brain glycogen serves a role in maintaining a proper ratio between excitatory and inhibitory neurotransmitters in type 2 diabetes." | 1.38 | Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2012) |
| "Glycogen levels were also lower in this region." | 1.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "Patients with type 2 diabetes and major depression (n=20) were scanned along with patients with diabetes alone (n=24) and healthy controls (n=21) on a 1." | 1.34 | Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. ( Ajilore, O; Binesh, N; Darwin, C; Haroon, E; Kumar, A; Kumaran, S; Miller, J; Mintz, J; Thomas, MA, 2007) |
| "A total of 83% of participants had type 2 diabetes." | 1.33 | T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study. ( Beck, SR; Bowden, DW; Burdon, KP; Freedman, BI; Langefeld, CD; Liu, Y; Rich, SS; Wagenknecht, LE, 2005) |
| "To clarify the genetic background of IDDMS, we analyzed HLA-DRB1, -DQB1 and -DQA1 alleles, phenotypes, and genotypes and compared them with acute-onset type 1 diabetes, non-insulin-dependent diabetes mellitus (NIDDM), and control subjects." | 1.33 | Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. ( Kazahari, M; Kikuchi, N; Koike, A; Matsuura, N; Nomoto, K; Ohtsu, S; Takubo, N; Yokota, F, 2005) |
| "Myo-inositol was even more elevated in patients with polyneuropathy (p = 0." | 1.32 | Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. ( Feuerbach, S; Fründ, R; Geissler, A; Schölmerich, J; Zietz, B, 2003) |
| "D76N was not associated with type 2 diabetes, either in our population or when all reported studies in Caucasians were combined." | 1.32 | Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes? ( Elbein, SC; Karim, MA, 2004) |
| "However, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24." | 1.30 | Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM. ( Babaya, N; Fujisawa, T; Hamada, Y; Ikegami, H; Kawabata, Y; Kawaguchi, Y; Nojima, K; Ogihara, T; Shen, GQ; Shintani, M; Ueda, H; Yamada, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.92) | 18.7374 |
| 1990's | 5 (9.80) | 18.2507 |
| 2000's | 16 (31.37) | 29.6817 |
| 2010's | 20 (39.22) | 24.3611 |
| 2020's | 8 (15.69) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Xian, TZ | 1 |
| Wu, MX | 1 |
| Li, C | 1 |
| Wang, W | 1 |
| Man, F | 1 |
| Zhang, X | 1 |
| Wang, X | 2 |
| Pan, Q | 1 |
| Guo, L | 1 |
| Wang, JW | 1 |
| Ye, XY | 1 |
| Wei, N | 1 |
| Wu, SS | 1 |
| Zhang, ZH | 1 |
| Luo, GH | 1 |
| Li, X | 1 |
| Li, J | 1 |
| Cao, H | 1 |
| Lv, Y | 3 |
| Zheng, Y | 3 |
| Zhao, X | 3 |
| Li, Z | 3 |
| Wang, G | 3 |
| Lee, RH | 1 |
| Bain, J | 1 |
| Muehlbauer, M | 1 |
| Ilkayeva, O | 1 |
| Pieper, C | 1 |
| Wixted, D | 1 |
| Colón-Emeric, C | 1 |
| Mizutani, N | 1 |
| Goda, K | 1 |
| Kenzaka, T | 1 |
| Liang, W | 1 |
| Feng, Y | 1 |
| Yang, D | 1 |
| Qin, J | 1 |
| Zhi, X | 1 |
| Wu, W | 1 |
| Jie, Q | 1 |
| Fukuda, M | 1 |
| Nagao, Y | 1 |
| Li, S | 1 |
| Yin, C | 1 |
| Zhao, W | 1 |
| Lian, X | 1 |
| Hong, Q | 1 |
| Luo, HH | 1 |
| Feng, XF | 1 |
| Yang, XL | 1 |
| Hou, RQ | 1 |
| Fang, ZZ | 1 |
| Wu, GY | 1 |
| Zhang, Q | 2 |
| Wu, JL | 1 |
| Jing, L | 1 |
| Tan, Y | 1 |
| Qiu, TC | 1 |
| Zhao, J | 1 |
| Wang, S | 2 |
| Wang, J | 1 |
| Zhang, R | 1 |
| Zhao, A | 1 |
| Zheng, X | 1 |
| Yan, D | 1 |
| Jiang, F | 1 |
| Jia, W | 2 |
| Hu, C | 1 |
| Vangipurapu, J | 1 |
| Stancáková, A | 1 |
| Smith, U | 1 |
| Kuusisto, J | 1 |
| Laakso, M | 1 |
| Fried, PJ | 1 |
| Pascual-Leone, A | 1 |
| Bolo, NR | 1 |
| Lin, Y | 1 |
| Zhou, J | 1 |
| Sha, L | 1 |
| Li, Y | 1 |
| Qu, X | 1 |
| Liu, L | 1 |
| Chen, H | 1 |
| An, Z | 1 |
| Wang, Y | 2 |
| Sun, C | 1 |
| Povlsen, JA | 1 |
| Løfgren, B | 1 |
| Dalgas, C | 1 |
| Birkler, RI | 1 |
| Johannsen, M | 1 |
| Støttrup, NB | 1 |
| Bøtker, HE | 1 |
| Zhang, M | 2 |
| Sun, X | 2 |
| Zhang, Z | 2 |
| Meng, Q | 2 |
| Chen, J | 1 |
| Ma, X | 1 |
| Geng, H | 2 |
| Sun, L | 2 |
| Hajek, T | 1 |
| Calkin, C | 1 |
| Blagdon, R | 1 |
| Slaney, C | 1 |
| Alda, M | 1 |
| Sinha, S | 1 |
| Ekka, M | 1 |
| Sharma, U | 1 |
| P, R | 1 |
| Pandey, RM | 1 |
| Jagannathan, NR | 1 |
| Tong, J | 1 |
| Zhu, X | 1 |
| Qian, R | 1 |
| Liang, Q | 1 |
| Yin, YW | 1 |
| Wang, Q | 1 |
| Sun, QQ | 1 |
| Hu, AM | 1 |
| Liu, HL | 1 |
| Stamenkovic, JA | 1 |
| Andersson, LE | 1 |
| Adriaenssens, AE | 1 |
| Bagge, A | 1 |
| Sharoyko, VV | 1 |
| Gribble, F | 1 |
| Reimann, F | 1 |
| Wollheim, CB | 1 |
| Mulder, H | 1 |
| Spégel, P | 1 |
| Kieffer, DM | 1 |
| Harteveld, CL | 1 |
| Lee, DH | 1 |
| Schiemsky, T | 1 |
| Desmet, KJ | 1 |
| Gillard, P | 1 |
| Shi, X | 1 |
| Zhang, Y | 1 |
| Niu, H | 1 |
| Wang, R | 1 |
| Shen, J | 1 |
| Zhou, S | 1 |
| Yang, H | 1 |
| Wu, J | 1 |
| Achilles, EI | 1 |
| Maus, V | 1 |
| Fink, GR | 1 |
| Maintz, D | 1 |
| van Eimeren, T | 1 |
| Mpotsaris, A | 1 |
| Heikkilä, O | 1 |
| Lundbom, N | 1 |
| Timonen, M | 1 |
| Groop, PH | 1 |
| Heikkinen, S | 1 |
| Mäkimattila, S | 1 |
| Odeberg, J | 1 |
| Larsson, CA | 1 |
| Råstam, L | 1 |
| Lindblad, U | 1 |
| Ouederni, TB | 1 |
| Sanchez-Corona, J | 1 |
| Flores Martinez, SE | 1 |
| Ben Maiz, H | 1 |
| Skhiri, HA | 1 |
| Abid, HK | 1 |
| Benammar-Elgaaied, A | 1 |
| Tiehuis, A | 1 |
| van der Meer, F | 1 |
| Mali, W | 1 |
| Pleizier, M | 1 |
| Biessels, GJ | 1 |
| Kappelle, J | 1 |
| Luijten, P | 1 |
| Sickmann, HM | 2 |
| Waagepetersen, HS | 2 |
| Schousboe, A | 2 |
| Benie, AJ | 2 |
| Bouman, SD | 2 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| D'Alfonso, R | 1 |
| Marini, MA | 1 |
| Frittitta, L | 1 |
| Sorge, R | 1 |
| Frontoni, S | 1 |
| Porzio, O | 1 |
| Mariani, LM | 1 |
| Lauro, D | 1 |
| Gambardella, S | 1 |
| Trischitta, V | 1 |
| Federici, M | 1 |
| Lauro, R | 1 |
| Sesti, G | 1 |
| Stefan, N | 1 |
| Kovacs, P | 1 |
| Stumvoll, M | 1 |
| Hanson, RL | 1 |
| Lehn-Stefan, A | 1 |
| Permana, PA | 1 |
| Baier, LJ | 1 |
| Tataranni, PA | 1 |
| Silver, K | 1 |
| Bogardus, C | 1 |
| Geissler, A | 1 |
| Fründ, R | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Zietz, B | 1 |
| Rudofsky, G | 1 |
| Reismann, P | 1 |
| Witte, S | 1 |
| Humpert, PM | 1 |
| Isermann, B | 1 |
| Chavakis, T | 1 |
| Tafel, J | 1 |
| Nosikov, VV | 1 |
| Hamann, A | 1 |
| Nawroth, P | 1 |
| Bierhaus, A | 1 |
| Chen, MW | 1 |
| Yang, MG | 1 |
| Wang, CJ | 1 |
| Wang, YM | 1 |
| Xu, XP | 1 |
| Liu, SQ | 1 |
| Sun, HY | 1 |
| Elbein, SC | 1 |
| Karim, MA | 1 |
| Liu, Y | 1 |
| Burdon, KP | 1 |
| Langefeld, CD | 1 |
| Beck, SR | 1 |
| Wagenknecht, LE | 1 |
| Rich, SS | 1 |
| Bowden, DW | 1 |
| Freedman, BI | 1 |
| Ohtsu, S | 1 |
| Takubo, N | 1 |
| Kazahari, M | 1 |
| Nomoto, K | 1 |
| Yokota, F | 1 |
| Kikuchi, N | 1 |
| Koike, A | 1 |
| Matsuura, N | 1 |
| Ajilore, O | 1 |
| Haroon, E | 1 |
| Kumaran, S | 1 |
| Darwin, C | 1 |
| Binesh, N | 1 |
| Mintz, J | 1 |
| Miller, J | 1 |
| Thomas, MA | 1 |
| Kumar, A | 1 |
| Schäffler, A | 1 |
| Zeitoun, M | 1 |
| Wobser, H | 1 |
| Buechler, C | 1 |
| Aslanidis, C | 1 |
| Herfarth, H | 1 |
| Modi, S | 1 |
| Bhattacharya, M | 1 |
| Sekhri, T | 1 |
| Rana, P | 1 |
| Tripathi, RP | 1 |
| Khushu, S | 1 |
| Shen, GQ | 1 |
| Ikegami, H | 1 |
| Kawaguchi, Y | 1 |
| Fujisawa, T | 1 |
| Hamada, Y | 1 |
| Ueda, H | 1 |
| Shintani, M | 1 |
| Nojima, K | 1 |
| Kawabata, Y | 1 |
| Yamada, K | 1 |
| Babaya, N | 1 |
| Ogihara, T | 1 |
| Dubois-Laforgue, D | 2 |
| Caillat-Zucman, S | 2 |
| Djilali-Saiah, I | 1 |
| Larger, E | 1 |
| Mercadier, A | 1 |
| Boitard, C | 2 |
| Bach, JF | 1 |
| Timsit, J | 2 |
| Bissé, E | 1 |
| Zorn, N | 1 |
| Eigel, A | 1 |
| Lizama, M | 1 |
| Huaman-Guillen, P | 1 |
| März, W | 1 |
| Van Dorsselaer, A | 1 |
| Wieland, H | 1 |
| Cai, H | 1 |
| Colagiuri, S | 1 |
| Wilcken, DE | 1 |
| Maegawa, H | 1 |
| Shi, K | 1 |
| Hidaka, H | 1 |
| Iwai, N | 1 |
| Nishio, Y | 1 |
| Egawa, K | 1 |
| Kojima, H | 1 |
| Haneda, M | 1 |
| Yasuda, H | 1 |
| Nakamura, Y | 1 |
| Kinoshita, M | 1 |
| Kikkawa, R | 1 |
| Kashiwagi, A | 1 |
| Song, DK | 1 |
| Ahn, YH | 1 |
| Bae, JH | 1 |
| Park, WK | 1 |
| Hong, YS | 1 |
| Ho, WK | 1 |
| Earm, YE | 1 |
| Filer, LJ | 1 |
| Stegink, LD | 1 |
| Deaver, OE | 1 |
| Wander, RC | 1 |
| McCusker, RH | 1 |
| Berdanier, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspartic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Changes in cerebral metabolites in type 2 diabetes mellitus: A meta-analysis of proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Diabetes Mellitus, Type 2; Humans; In | 2017 |
Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabetes mellitus: a meta-analysis of 15,059 subjects.
Topics: Amino Acid Substitution; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Genetic Pre | 2015 |
1 trial available for aspartic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial.
Topics: Aspartic Acid; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide-1 Receptor; Glycated Hemo | 2022 |
48 other studies available for aspartic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Reactive Oxygen Species Contributes to Type 2 Diabetic Neuropathic Pain via the Thioredoxin-Interacting Protein-NOD-Like Receptor Protein 3- N -Methyl-D-Aspartic Acid Receptor 2B Pathway.
Topics: Animals; Aspartic Acid; Caspases; Cell Cycle Proteins; Diabetes Mellitus, Experimental; Diabetes Mel | 2022 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study.
Topics: Aged; Amino Acids; Asparagine; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Fatty | 2023 |
A Case of Milk-Alkali Syndrome Caused by Diuretic-Induced Alkalosis and Polypharmacy.
Topics: Aged; Aged, 80 and over; Alkalosis; Aspartic Acid; Calcium; Diabetes Mellitus, Type 2; Diuretics; Fe | 2023 |
Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus.
Topics: Animals; Asparagine; Aspartic Acid; B-Lymphocytes, Regulatory; Diabetes Mellitus, Type 2; Diabetes, | 2023 |
Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report.
Topics: Arginine; Aspartic Acid; Biomarkers; Deafness; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Growth | 2019 |
Application of Hydrogen Proton Magnetic Resonance Technology Combined with Brain Neurometabolite Analysis in the Treatment of Cognitive Impairment Caused by Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Aspartic Acid; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Female; Humans; Hydrog | 2020 |
Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk.
Topics: Adolescent; Adult; Aging; Asian People; Asparagine; Aspartic Acid; China; Diabetes Mellitus, Type 2; | 2020 |
Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cas | 2019 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; | 2019 |
Metabolite differences in the lenticular nucleus in type 2 diabetes mellitus shown by proton MR spectroscopy.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Diabetes Mel | 2013 |
Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.
Topics: Animals; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Heart Function Tests; Hem | 2013 |
Brain metabolite changes in patients with type 2 diabetes and cerebral infarction using proton magnetic resonance spectroscopy.
Topics: Aged; Aspartic Acid; Blood Glucose; Brain; Cerebral Infarction; Choline; Creatine; Diabetes Mellitus | 2014 |
Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Creatine; Cross-Sectional Studies; Diabetes Mellitus, | 2015 |
Assessment of changes in brain metabolites in Indian patients with type-2 diabetes mellitus using proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Chemistry; Choline; Creatinine; Diabetes Mellitus, Type 2; Glucose; Glutamic Ac | 2014 |
Brain metabolite alterations demonstrated by proton magnetic resonance spectroscopy in diabetic patients with retinopathy.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Corpus Striatum; Diabetes Mellitus, Type | 2014 |
Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.
Topics: Animals; Aspartic Acid; Cell Line; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Secreting Cells; Gl | 2015 |
Hemoglobin A2-Leuven (α2δ2 143(H21) His>Asp): a novel delta-chain variant potentially interfering in hemoglobin A1c measurement using cation exchange HPLC.
Topics: Adult; Aspartic Acid; Cations; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; D | 2016 |
[Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus].
Topics: Adult; Aspartic Acid; Case-Control Studies; Cerebrum; Choline; Cognition; Cognition Disorders; Creat | 2016 |
[Hemichorea with Contralateral High Signal Intensity Putaminal Lesion on T1-Weighted Images in Non-Ketotic Hyperglycemia].
Topics: Aspartic Acid; Choline; Chorea; Creatine; Diabetes Complications; Diabetes Mellitus, Type 2; Diffusi | 2016 |
Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism.
Topics: Adult; Anthropometry; Aspartic Acid; Blood Glucose; Choline; Creatine; Diabetes Mellitus, Type 2; Hu | 2008 |
The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus.
Topics: Alleles; Aspartic Acid; Data Collection; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Age | 2008 |
The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population.
Topics: Aspartic Acid; Black People; Diabetes Mellitus, Type 2; Ethnicity; Female; Genetic Predisposition to | 2009 |
MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Di | 2010 |
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Diabetes Mellitus, Type 2; gamma | 2010 |
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Diabetes Mellitus, Type 2; gamma-Aminobuty | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.
Topics: Adult; Aged; Alleles; Aspartic Acid; Cohort Studies; Diabetes Mellitus, Type 2; Fibroblasts; Gene Fr | 2003 |
Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.
Topics: Adult; Amino Acid Substitution; Animals; Arizona; Aspartic Acid; Base Sequence; Body Composition; Co | 2003 |
Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Chlorides; Choline; Creatinine; Diabetes Mellitus, Type | 2003 |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
Topics: Amino Acid Substitution; Aspartic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabet | 2004 |
[Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province].
Topics: Adult; Alleles; Aspartic Acid; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; H | 2004 |
Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes?
Topics: Age of Onset; Amino Acid Substitution; Asparagine; Aspartic Acid; Case-Control Studies; Diabetes Mel | 2004 |
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Topics: Aged; Albuminuria; Aspartic Acid; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus | 2005 |
Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.
Topics: Age of Onset; Arginine; Asian People; Aspartic Acid; Autoantibodies; Case-Control Studies; Child; Ch | 2005 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disord | 2007 |
Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases.
Topics: Amino Acid Substitution; Aspartic Acid; Chronic Disease; Cohort Studies; Cytokines; Diabetes Mellitu | 2007 |
Assessment of the metabolic profile in Type 2 diabetes mellitus and hypothyroidism through proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Diabetes Mellitus, Type 2; Female; Humans; Hypothyro | 2008 |
Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Aspartic Acid; Body Mass Index; Data Interpretation, | 1998 |
Mutations in HFE, the hemochromatosis candidate gene, in patients with NIDDM.
Topics: Amino Acid Substitution; Aspartic Acid; Cysteine; Diabetes Mellitus, Type 2; Hemochromatosis; Hemoch | 1998 |
Hemoglobin Rambam (beta69[E13]Gly-->Asp), a pitfall in the assessment of diabetic control: characterization by electrospray mass spectrometry and HPLC.
Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; | 1998 |
A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes.
Topics: Albuminuria; Amino Acid Substitution; Angina Pectoris; Aspartic Acid; Cerebrovascular Disorders; Dia | 1998 |
The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.
Topics: 3' Untranslated Regions; Alleles; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Fe | 1999 |
Evidence of enhancement of malate-aspartate shuttle activity in beta cells of streptozotocin-induced non-insulin-dependent diabetic rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Blood Glucose; Cells, Cultured; Diabetes Mellitus, E | 2000 |
Clinical characteristics of type 2 diabetes in patients with mutations of HFE.
Topics: Amino Acid Substitution; Aspartic Acid; Cysteine; Diabetes Mellitus, Type 2; Female; Ferritins; Hemo | 2000 |
Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects.
Topics: Adult; Aspartame; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Erythrocytes; | 1989 |
Diet effects on membrane phospholipid fatty acids and mitochondrial function in BHE rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspartic Acid; Coconut Oil; Corn Oil; Dia | 1986 |