aspartic acid has been researched along with Diabetes Mellitus, Type 1 in 54 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The response of the subjects with IDDM was similar to that of the normal subjects." | 2.70 | Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea. ( Hamadeh, MJ; Hoffer, LJ, 2001) |
| "Forty-eight IDDM patients and 59 nondiabetic unrelated control subjects were recruited from the population in Taiwan." | 2.67 | HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan. ( Chen, KH; Chuang, LM; Hsieh, RP; Hu, CY; Jou, TS; Lee, JS; Lin, BJ; Tai, TY; Tsai, WY; Wu, HP, 1994) |
| "In 25 children, 6-14 years of age, with type 1 diabetes across 3 sites, we acquired T1WI and axial 2D MRSI along with phantom studies to calibrate scanner effects." | 1.91 | Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children. ( Alonso, GT; Anderson, AW; Cai, LY; Ghetti, S; Glaser, N; Gwal, K; Jaser, SS; Jones, RS; Jordan, LC; Juvera, J; Kang, H; Landman, BA; Lee, CA; LeStourgeon, LM; Mahon, A; Ozturk, A; Patel, NJ; Pruthi, S; Rewers, A; Rewers, MJ; Taki, I; Tanase, C, 2023) |
| "DKA at type 1 diabetes diagnosis results in morphologic and functional brain changes." | 1.40 | Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. ( Cameron, FJ; Finney, K; Inder, TE; Jennings, J; Koves, I; Mackay, M; Nadebaum, C; Neil, JJ; Northam, EA; Scratch, SE; Wellard, RM, 2014) |
| "The impact of type 1 diabetes mellitus (T1DM) on a comprehensive neurochemical profile of the human brain has not been reported yet." | 1.39 | Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T. ( Eberly, LE; Kumar, AF; Mangia, S; Moheet, AA; Roberts, RJ; Seaquist, ER; Tkáč, I, 2013) |
| "A total of 83% of participants had type 2 diabetes." | 1.33 | T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study. ( Beck, SR; Bowden, DW; Burdon, KP; Freedman, BI; Langefeld, CD; Liu, Y; Rich, SS; Wagenknecht, LE, 2005) |
| "Autoimmune diabetes is a complex, multifactorial disease caused by the interaction of genetic and environmental factors." | 1.33 | [HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA)]. ( Caputo, M; Cedola, N; Cerrone, GE; Frechtel, GD; Gonzalez, C; Lopez, AP; Mazza, C; Puchulu, FM; Targovnik, HM, 2005) |
| "To clarify the genetic background of IDDMS, we analyzed HLA-DRB1, -DQB1 and -DQA1 alleles, phenotypes, and genotypes and compared them with acute-onset type 1 diabetes, non-insulin-dependent diabetes mellitus (NIDDM), and control subjects." | 1.33 | Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. ( Kazahari, M; Kikuchi, N; Koike, A; Matsuura, N; Nomoto, K; Ohtsu, S; Takubo, N; Yokota, F, 2005) |
| "Myo-inositol was even more elevated in patients with polyneuropathy (p = 0." | 1.32 | Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. ( Feuerbach, S; Fründ, R; Geissler, A; Schölmerich, J; Zietz, B, 2003) |
| "Eleven IDDM patients with no history of severe hypoglycemia (group A) were compared with 11 IDDM patients who had a history of five or more episodes of severe hypoglycemia (group B)." | 1.30 | Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia. ( Best, JJ; Deary, IJ; Frier, BM; Perros, P; Sellar, RJ, 1997) |
| "By contrast, IDDM patients with no Ab showed no particular association with HLA class II allele although they had clinical and metabolic characteristics similar to that of Ab-positive subjects." | 1.30 | Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects. ( Boitard, C; Caillat-Zucman, S; Djilali-Saiah, I; Dubois-Laforgue, D; Timsit, J, 1997) |
| "Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively." | 1.30 | The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules. ( Buus, S; Holm, A; Johansen, BH; Paulsen, G; Quarsten, H; Sollid, LM; Thorpe, CJ, 1998) |
| "Sixty-nine IDDM patients and 47 healthy controls in a Southern Chinese population were HLA-DQB1 genotyped by one-step sequence specific polymerase chain reaction (ssPCR)." | 1.30 | Contribution of the absence of aspartic acid at position 57 of the HLA-DQ beta chain to predisposition to insulin-dependent diabetes mellitus in a southern Chinese population. ( Cheng, H; Fu, Z; Yan, T; Zhang, S; Zhong, G, 1998) |
| "In human IDDM it has been suggested that the presence of an aspartate at position 57 of the DQ beta-chain might be important in determining resistance to development of IDDM." | 1.29 | Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. ( Chandler, P; Day, S; Hutchings, PR; Kioussis, D; Lund, T; O'Reilly, L; Ozegbe, P; Picard, J; Quartey-Papafio, R; Simpson, E, 1995) |
| "HLA-DQ beta alleles are genetic susceptibility markers in New Zealand, and other Caucasian populations." | 1.29 | HLA-DQ beta typing and non-Asp57 alleles in IDDM and nondiabetic subjects in New Zealand. ( Brown, LJ; Forbes, LV; Scott, RS, 1993) |
| "HLA-DQ beta 1 alleles may be genetic susceptibility markers for IDDM in the Senegalese population, as they are in Caucasian populations." | 1.29 | HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of Senegal. ( Chauffert, M; Chevenne, D; Cisse, A; Michel, S; Parfait, B; Trivin, F, 1995) |
| "MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder." | 1.29 | Role of HLA class II alleles in Korean patients with IDDM. ( Chung, YS; Fugisawa, T; Fujisawa, T; Huh, KB; Ikegami, H; Kim, DH; Kim, KR; Kim, YS; Lee, DS; Lee, EJ; Lee, HC; Lim, SK; Ogihara, T; Park, JO; Park, SW, 1996) |
| "Thus, susceptibility to Type 1 diabetes in Spanish patients is associated, quantitatively, with non-Asp 57 DQ beta and Arg 52 DQ alpha alleles." | 1.28 | Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles. ( Bertera, S; Chantres, MT; Dorman, JS; Gutierrez-Lopez, MD; Serrano-Rios, M; Trucco, M; Vavassori, C, 1992) |
| "Insulin-dependent diabetes mellitus (IDDM) in Caucasians is closely associated with the HLA-DQ gene, especially the residue 57 of the DQ beta chain." | 1.28 | Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people. ( Cha, T; Ikegami, H; Noma, Y; Ogihara, T; Shima, K; Tahara, Y; Yamato, E, 1990) |
| "Thirty-five (48." | 1.28 | High frequency of aspartic acid at position 57 of HLA-DQ beta-chain in Japanese IDDM patients and nondiabetic subjects. ( Awata, T; Iwamoto, Y; Juji, T; Kanazawa, Y; Kuzuya, T; Matsuda, A; Okuyama, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.26) | 18.7374 |
| 1990's | 28 (51.85) | 18.2507 |
| 2000's | 13 (24.07) | 29.6817 |
| 2010's | 6 (11.11) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, LY | 1 |
| Tanase, C | 1 |
| Anderson, AW | 1 |
| Patel, NJ | 1 |
| Lee, CA | 1 |
| Jones, RS | 1 |
| LeStourgeon, LM | 1 |
| Mahon, A | 1 |
| Taki, I | 1 |
| Juvera, J | 1 |
| Pruthi, S | 1 |
| Gwal, K | 1 |
| Ozturk, A | 1 |
| Kang, H | 1 |
| Rewers, A | 1 |
| Rewers, MJ | 1 |
| Alonso, GT | 1 |
| Glaser, N | 1 |
| Ghetti, S | 1 |
| Jaser, SS | 1 |
| Landman, BA | 1 |
| Jordan, LC | 1 |
| Crawford, SA | 1 |
| Groegler, J | 1 |
| Dang, M | 1 |
| Michel, C | 1 |
| Powell, RL | 1 |
| Hohenstein, AC | 1 |
| Reyes, K | 1 |
| Haskins, K | 1 |
| Wiles, TA | 1 |
| Delong, T | 1 |
| Hansen, TM | 1 |
| Brock, B | 1 |
| Juhl, A | 1 |
| Drewes, AM | 1 |
| Vorum, H | 1 |
| Andersen, CU | 1 |
| Jakobsen, PE | 1 |
| Karmisholt, J | 1 |
| Frøkjær, JB | 1 |
| Brock, C | 1 |
| Mangia, S | 1 |
| Kumar, AF | 1 |
| Moheet, AA | 1 |
| Roberts, RJ | 1 |
| Eberly, LE | 1 |
| Seaquist, ER | 1 |
| Tkáč, I | 1 |
| Cameron, FJ | 1 |
| Scratch, SE | 1 |
| Nadebaum, C | 1 |
| Northam, EA | 1 |
| Koves, I | 1 |
| Jennings, J | 1 |
| Finney, K | 1 |
| Neil, JJ | 1 |
| Wellard, RM | 2 |
| Mackay, M | 1 |
| Inder, TE | 1 |
| Zhang, H | 1 |
| Huang, M | 1 |
| Gao, L | 1 |
| Lei, H | 1 |
| Kato, I | 1 |
| Oya, T | 1 |
| Suzuki, H | 1 |
| Takasawa, K | 1 |
| Ichsan, AM | 1 |
| Nakada, S | 1 |
| Ishii, Y | 1 |
| Shimada, Y | 1 |
| Sasahara, M | 1 |
| Tobe, K | 1 |
| Takasawa, S | 1 |
| Okamoto, H | 1 |
| Hiraga, K | 1 |
| Wootton-Gorges, SL | 1 |
| Buonocore, MH | 1 |
| Caltagirone, RA | 1 |
| Kuppermann, N | 1 |
| Glaser, NS | 1 |
| Wang, WT | 1 |
| Lee, P | 1 |
| Yeh, HW | 1 |
| Smirnova, IV | 1 |
| Choi, IY | 1 |
| Geissler, A | 1 |
| Fründ, R | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Zietz, B | 1 |
| Rudofsky, G | 1 |
| Reismann, P | 1 |
| Witte, S | 1 |
| Humpert, PM | 1 |
| Isermann, B | 1 |
| Chavakis, T | 1 |
| Tafel, J | 1 |
| Nosikov, VV | 1 |
| Hamann, A | 1 |
| Nawroth, P | 1 |
| Bierhaus, A | 1 |
| Yu, J | 1 |
| Shin, CH | 1 |
| Yang, SW | 1 |
| Park, MH | 1 |
| Eisenbarth, GS | 1 |
| Liu, Y | 1 |
| Burdon, KP | 1 |
| Langefeld, CD | 1 |
| Beck, SR | 1 |
| Wagenknecht, LE | 1 |
| Rich, SS | 1 |
| Bowden, DW | 1 |
| Freedman, BI | 1 |
| Sarac, K | 1 |
| Akinci, A | 1 |
| Alkan, A | 1 |
| Aslan, M | 1 |
| Baysal, T | 1 |
| Ozcan, C | 1 |
| Caputo, M | 1 |
| Cerrone, GE | 1 |
| Lopez, AP | 1 |
| Gonzalez, C | 1 |
| Mazza, C | 1 |
| Cedola, N | 1 |
| Puchulu, FM | 1 |
| Targovnik, HM | 1 |
| Frechtel, GD | 1 |
| Rankins, D | 1 |
| Cameron, F | 1 |
| McDonnell, C | 1 |
| Northam, E | 1 |
| Ohtsu, S | 1 |
| Takubo, N | 1 |
| Kazahari, M | 1 |
| Nomoto, K | 1 |
| Yokota, F | 1 |
| Kikuchi, N | 1 |
| Koike, A | 1 |
| Matsuura, N | 1 |
| Quartey-Papafio, R | 1 |
| Lund, T | 1 |
| Chandler, P | 1 |
| Picard, J | 1 |
| Ozegbe, P | 1 |
| Day, S | 1 |
| Hutchings, PR | 1 |
| O'Reilly, L | 1 |
| Kioussis, D | 1 |
| Simpson, E | 1 |
| Sanjeevi, CB | 1 |
| Lybrand, TP | 1 |
| DeWeese, C | 1 |
| Landin-Olsson, M | 1 |
| Kockum, I | 1 |
| Dahlquist, G | 1 |
| Sundkvist, G | 1 |
| Stenger, D | 1 |
| Lernmark, A | 1 |
| Chuang, LM | 1 |
| Jou, TS | 1 |
| Hu, CY | 1 |
| Wu, HP | 1 |
| Tsai, WY | 1 |
| Lee, JS | 1 |
| Hsieh, RP | 1 |
| Chen, KH | 1 |
| Tai, TY | 1 |
| Lin, BJ | 1 |
| Maruyama, T | 1 |
| Shimada, A | 1 |
| Kasuga, A | 1 |
| Kasatani, T | 1 |
| Ozawa, Y | 1 |
| Ishii, M | 1 |
| Takei, I | 1 |
| Suzuki, Y | 1 |
| Kobayashi, A | 1 |
| Takeda, S | 1 |
| Forbes, LV | 1 |
| Brown, LJ | 1 |
| Scott, RS | 1 |
| Patel, P | 1 |
| Lo, YM | 1 |
| Bell, JI | 1 |
| Wainscoat, JS | 1 |
| Chauffert, M | 1 |
| Cisse, A | 1 |
| Chevenne, D | 1 |
| Parfait, B | 1 |
| Michel, S | 1 |
| Trivin, F | 1 |
| Lee, HC | 1 |
| Ikegami, H | 2 |
| Fujisawa, T | 1 |
| Ogihara, T | 2 |
| Park, SW | 1 |
| Chung, YS | 1 |
| Park, JO | 1 |
| Lee, EJ | 1 |
| Lim, SK | 1 |
| Kim, KR | 1 |
| Huh, KB | 1 |
| Kim, YS | 1 |
| Lee, DS | 1 |
| Kim, DH | 1 |
| Fugisawa, T | 1 |
| Perros, P | 1 |
| Deary, IJ | 1 |
| Sellar, RJ | 1 |
| Best, JJ | 1 |
| Frier, BM | 1 |
| Antoniou, AN | 1 |
| Elliott, J | 1 |
| Rosmarakis, E | 1 |
| Dyson, PJ | 1 |
| Dubois-Laforgue, D | 1 |
| Timsit, J | 1 |
| Djilali-Saiah, I | 1 |
| Boitard, C | 1 |
| Caillat-Zucman, S | 1 |
| Bowen, J | 1 |
| Richards, T | 1 |
| Maravilla, K | 1 |
| Quarsten, H | 1 |
| Paulsen, G | 1 |
| Johansen, BH | 1 |
| Thorpe, CJ | 1 |
| Holm, A | 1 |
| Buus, S | 1 |
| Sollid, LM | 1 |
| Bartnes, K | 1 |
| Li, X | 1 |
| Briand, JP | 1 |
| Travers, PJ | 1 |
| Hannestad, K | 1 |
| Corper, AL | 1 |
| Stratmann, T | 1 |
| Apostolopoulos, V | 1 |
| Scott, CA | 1 |
| Garcia, KC | 1 |
| Kang, AS | 1 |
| Wilson, IA | 1 |
| Teyton, L | 1 |
| Ettinger, RA | 1 |
| Liu, AW | 1 |
| Nepom, GT | 1 |
| Kwok, WW | 1 |
| Zhang, S | 1 |
| Cheng, H | 1 |
| Fu, Z | 1 |
| Zhong, G | 1 |
| Yan, T | 1 |
| Weintrob, N | 1 |
| Sprecher, E | 1 |
| Israel, S | 1 |
| Pinhas-Hamiel, O | 1 |
| Kwon, OJ | 1 |
| Bloch, K | 1 |
| Abramov, N | 1 |
| Arbel, A | 1 |
| Josefsberg, Z | 1 |
| Brautbar, C | 1 |
| Vardi, P | 1 |
| Hamadeh, MJ | 1 |
| Hoffer, LJ | 1 |
| Trucco, M | 6 |
| Awata, T | 2 |
| Kuzuya, T | 2 |
| Matsuda, A | 2 |
| Iwamoto, Y | 2 |
| Kanazawa, Y | 2 |
| Gutierrez-Lopez, MD | 1 |
| Bertera, S | 1 |
| Chantres, MT | 1 |
| Vavassori, C | 1 |
| Dorman, JS | 3 |
| Serrano-Rios, M | 1 |
| Martinez-Laso, J | 1 |
| Vicario, JL | 1 |
| Corell, A | 1 |
| Martin-Villa, JM | 1 |
| Morales, P | 1 |
| Lledó, G | 1 |
| Arnaiz-Villena, A | 1 |
| Ju, LY | 1 |
| Sun, YP | 1 |
| Semana, G | 1 |
| Gu, XF | 1 |
| Krishnamoorty, R | 1 |
| Fauchet, R | 1 |
| Charron, D | 1 |
| Reijonen, H | 1 |
| Ilonen, J | 1 |
| Knip, M | 1 |
| Akerblom, HK | 1 |
| Boehm, BO | 2 |
| Scherbaum, WA | 1 |
| Schöffling, K | 2 |
| Kühnl, P | 1 |
| Althoff, P | 1 |
| Manfras, B | 2 |
| Usadel, KH | 1 |
| Tahara, Y | 1 |
| Cha, T | 1 |
| Yamato, E | 1 |
| Noma, Y | 1 |
| Shima, K | 1 |
| Olerup, O | 1 |
| Smith, CI | 1 |
| Hammarström, L | 1 |
| Rosak, C | 1 |
| Miyazaki, T | 1 |
| Uno, M | 1 |
| Uehira, M | 1 |
| Kikutani, H | 1 |
| Kishimoto, T | 1 |
| Kimoto, M | 1 |
| Nishimoto, H | 1 |
| Miyazaki, J | 1 |
| Yamamura, K | 1 |
| Okuyama, M | 1 |
| Juji, T | 1 |
| Vallet-Colom, I | 1 |
| Lévy-Marchal, C | 1 |
| Zarrouk, D | 1 |
| Tichet, J | 1 |
| Krishnamoorthy, R | 1 |
| Czernichow, P | 1 |
| Elion, J | 1 |
| Yamagata, K | 1 |
| Nakajima, H | 1 |
| Hanafusa, T | 1 |
| Noguchi, T | 1 |
| Miyazaki, A | 1 |
| Miyagawa, J | 1 |
| Sada, M | 1 |
| Amemiya, H | 1 |
| Tanaka, T | 1 |
| Kono, N | 1 |
| Bao, MZ | 1 |
| Wang, JX | 1 |
| Rønningen, KS | 1 |
| Iwe, T | 1 |
| Halstensen, TS | 1 |
| Spurkland, A | 1 |
| Thorsby, E | 1 |
| Rusting, R | 1 |
| Morel, PA | 1 |
| Todd, JA | 1 |
| McDevitt, HO | 1 |
1 review available for aspartic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
To be or not to be Asp 57, that is the question.
Topics: Amino Acid Sequence; Aspartic Acid; Child; Diabetes Mellitus, Type 1; Genetic Markers; Haplotypes; H | 1992 |
2 trials available for aspartic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan.
Topics: Adolescent; Alleles; Aspartic Acid; China; Codon; Diabetes Mellitus, Type 1; Gene Frequency; Genotyp | 1994 |
Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Diabetes Mellitus, Type 1; Diet, Protein-Restricted; Fem | 2001 |
51 other studies available for aspartic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.
Topics: Aspartic Acid; Brain; Child; Choline; Creatine; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Gl | 2023 |
Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate.
Topics: Animals; Aspartic Acid; Diabetes Mellitus, Type 1; Humans; In Vitro Techniques; Insulin; Insulin-Sec | 2023 |
Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Case-Control Studies; Diabetes Mellitus, Type 1; Diabe | 2019 |
Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T.
Topics: Adult; Aspartic Acid; Brain; Diabetes Mellitus, Type 1; Female; Glutamic Acid; Humans; Magnetic Reso | 2013 |
Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children.
Topics: Adolescent; Aspartic Acid; Brain; Child; Cognition Disorders; Diabetes Mellitus, Type 1; Diabetic Ke | 2014 |
Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Corpus Striatum; Diabetes Mellitus, Experime | 2015 |
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; Calcium-Calmodulin-D | 2008 |
Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.
Topics: Adolescent; Aspartic Acid; Basal Ganglia; Blood Glucose; Brain; Brain Damage, Chronic; Brain Edema; | 2010 |
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T.
Topics: Acute Disease; Algorithms; Animals; Aspartic Acid; Biological Transport, Active; Blood Glucose; Bloo | 2012 |
Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Chlorides; Choline; Creatinine; Diabetes Mellitus, Type | 2003 |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
Topics: Amino Acid Substitution; Aspartic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabet | 2004 |
Analysis of children with type 1 diabetes in Korea: high prevalence of specific anti-islet autoantibodies, immunogenetic similarities to Western populations with "unique" haplotypes, and lack of discrimination by aspartic acid at position 57 of DQB.
Topics: Adolescent; Adult; Aspartic Acid; Autoantibodies; Child; Child, Preschool; Diabetes Mellitus, Type 1 | 2004 |
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Topics: Aged; Albuminuria; Aspartic Acid; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus | 2005 |
Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Child; Choline; Creatinine; Diabetes | 2005 |
[HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA)].
Topics: Adolescent; Adult; Age of Onset; Argentina; Aspartic Acid; Autoimmune Diseases; Case-Control Studies | 2005 |
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes.
Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Fo | 2005 |
Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.
Topics: Age of Onset; Arginine; Asian People; Aspartic Acid; Autoantibodies; Case-Control Studies; Child; Ch | 2005 |
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
Topics: Amino Acid Sequence; Animals; Antigen-Presenting Cells; Aspartic Acid; Base Sequence; Cyclophosphami | 1995 |
Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study.
Topics: Adolescent; Amino Acid Sequence; Amino Acids; Arginine; Aspartic Acid; Child; Child, Preschool; Diab | 1995 |
Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay.
Topics: Adolescent; Adult; Aged; Alleles; Arginine; Aspartic Acid; Child; Child, Preschool; Diabetes Mellitu | 1994 |
HLA-DQ beta typing and non-Asp57 alleles in IDDM and nondiabetic subjects in New Zealand.
Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Gene | 1993 |
Rapid HLA typing by multiplex amplification refractory mutation system.
Topics: Alleles; Arginine; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Disease Susceptibility; | 1993 |
HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of Senegal.
Topics: Adolescent; Adult; Alleles; Aspartic Acid; Black People; Child; Diabetes Mellitus, Type 1; Female; G | 1995 |
Role of HLA class II alleles in Korean patients with IDDM.
Topics: Adult; Alleles; Arginine; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Genes, M | 1996 |
Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia.
Topics: Adult; Aspartic Acid; Atrophy; Blood Glucose; Brain; Cerebral Cortex; Choline; Cognition; Cohort Stu | 1997 |
MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection.
Topics: Amino Acid Sequence; Animals; Antibodies; Arginine; Aspartic Acid; Cells, Cultured; Diabetes Mellitu | 1998 |
Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.
Topics: Adolescent; Adult; Alleles; Aspartic Acid; Autoantibodies; Child; Diabetes Mellitus, Type 1; Haploty | 1997 |
MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA.
Topics: Adult; Amino Acid Substitution; Aspartic Acid; Basal Ganglia; Base Sequence; Brain; Cerebral Cortex; | 1998 |
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules.
Topics: Alanine; Alleles; Aspartic Acid; B-Lymphocytes; Binding Sites; Cell Line; Computer Simulation; Diabe | 1998 |
The P9 peptide sidechain specificity of I-Ad.
Topics: Animals; Antigen Presentation; Aspartic Acid; Capsid; Capsid Proteins; Cross Reactions; Diabetes Mel | 1999 |
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.
Topics: Alleles; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspartic Acid; Crystallography, X-Ray; Dia | 2000 |
Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus.
Topics: Alleles; Amino Acid Substitution; Antigens, Differentiation, B-Lymphocyte; Aspartic Acid; Cell Line, | 2000 |
Contribution of the absence of aspartic acid at position 57 of the HLA-DQ beta chain to predisposition to insulin-dependent diabetes mellitus in a southern Chinese population.
Topics: Adolescent; Adult; Alleles; Asian People; Aspartic Acid; Child; Child, Preschool; Diabetes Mellitus, | 1998 |
Type 1 diabetes environmental factors and correspondence analysis of HLA class II genes in the Yemenite Jewish community in Israel.
Topics: Adult; Aged; Alleles; Animals; Aspartic Acid; Cattle; Diabetes Mellitus, Type 1; Emigration and Immi | 2001 |
Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Gene Frequenc | 1992 |
Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.
Topics: Alleles; Arginine; Aspartic Acid; Base Sequence; Cells, Cultured; Diabetes Mellitus, Type 1; Disease | 1992 |
Exclusive HLA-DQ factors do not explain susceptibility to insulin-dependent diabetes.
Topics: Alleles; Arginine; Aspartic Acid; Diabetes Mellitus, Type 1; DNA Probes; Histocompatibility Testing; | 1991 |
Aspartic acid at position 57 of the HLA-DQ beta chain in insulin-dependent diabetes mellitus: an association with one DRw9-DQw9 subtype in the Chinese population.
Topics: Alleles; Asian People; Aspartic Acid; Base Sequence; China; Diabetes Mellitus, Type 1; Disease Susce | 1991 |
HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.
Topics: Adolescent; Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; D | 1991 |
Prevalence of HLA-DQ beta chain non-Asp alleles in type I (insulin-dependent) diabetics with young and older ages of onset.
Topics: Adolescent; Adult; Alleles; Aspartic Acid; Chi-Square Distribution; Child; Child, Preschool; Diabete | 1991 |
Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people.
Topics: Amino Acids; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; HLA-DQ Antigens; Humans; Japan | 1990 |
Different amino acids at position 57 of the HLA-DQ beta chain associated with susceptibility and resistance to IgA deficiency.
Topics: Amino Acid Sequence; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Genetic Marke | 1990 |
Aspartic acid at position 57 of the HLA-DQ beta chain is protective against future development of insulin-dependent (type 1) diabetes mellitus.
Topics: Adult; Amino Acid Sequence; Aspartic Acid; Autoantibodies; Diabetes Mellitus, Type 1; Female; Geneti | 1991 |
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Topics: Animals; Aspartic Acid; Base Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; F | 1990 |
High frequency of aspartic acid at position 57 of HLA-DQ beta-chain in Japanese IDDM patients and nondiabetic subjects.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Asian People; Aspartic Acid; Base Sequence; Chromosome | 1990 |
HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.
Topics: Alanine; Alleles; Aspartic Acid; Child; Codon; Diabetes Mellitus, Type 1; France; Gene Frequency; Ge | 1990 |
Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Topics: Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Genes, MHC Class II; Genetic Predisposition | 1989 |
HLA-DQ beta non-ASP-57 allele and incidence of diabetes in China and the USA.
Topics: Alleles; Aspartic Acid; China; Chromosome Mapping; Diabetes Mellitus, Type 1; Disease Susceptibility | 1989 |
The amino acid at position 57 of the HLA-DQ beta chain and susceptibility to develop insulin-dependent diabetes mellitus.
Topics: Adolescent; Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; D | 1989 |
The 57th variety.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Diabetes Mellitus, Type 1; Genetic Therapy; HLA-DQ Anti | 1988 |
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.
Topics: Aspartic Acid; Base Sequence; Codon; Diabetes Mellitus, Type 1; Disease Susceptibility; Female; Hapl | 1988 |