aspartic acid has been researched along with Cystic Fibrosis in 7 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The glycine-to-aspartic acid missense mutation at codon 551 (G551D), which is within the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator (CFTR), is the third most common cystic fibrosis (CF) mutation, with a worldwide frequency of 3." | 3.68 | Cystic fibrosis patients bearing both the common missense mutation Gly----Asp at codon 551 and the delta F508 mutation are clinically indistinguishable from delta F508 homozygotes, except for decreased risk of meconium ileus. ( Brock, DJ; Corey, M; Durie, P; Hamosh, A; Keston, M; King, TM; Levison, H; McIntosh, I; Rosenstein, BJ; Tsui, LC, 1992) |
| "Pancreatic insufficiency was present in adult group, with recurrent pancreatitis in 1 present." | 1.48 | V232D mutation in patients with cystic fibrosis: Not so rare, not so mild. ( Barros-Angueira, F; Colon-Mejeras, C; Couce, ML; Fernández-Lorenzo, AE; Leis, R; Moreno-Álvarez, A; Sirvent-Gómez, J; Solar-Boga, A, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández-Lorenzo, AE | 1 |
| Moreno-Álvarez, A | 1 |
| Colon-Mejeras, C | 1 |
| Barros-Angueira, F | 1 |
| Solar-Boga, A | 1 |
| Sirvent-Gómez, J | 1 |
| Couce, ML | 1 |
| Leis, R | 1 |
| Venerando, A | 1 |
| Cesaro, L | 1 |
| Marin, O | 1 |
| Donella-Deana, A | 1 |
| Pinna, LA | 1 |
| Melin, P | 1 |
| Thoreau, V | 1 |
| Norez, C | 1 |
| Bilan, F | 1 |
| Kitzis, A | 1 |
| Becq, F | 1 |
| Picci, L | 1 |
| Cameran, M | 1 |
| Olante, P | 1 |
| Zacchello, F | 1 |
| Scarpa, M | 1 |
| Thomas, GR | 1 |
| Costelloe, EA | 1 |
| Lunn, DP | 1 |
| Stacey, KJ | 1 |
| Delaney, SJ | 1 |
| Passey, R | 1 |
| McGlinn, EC | 1 |
| McMorran, BJ | 1 |
| Ahadizadeh, A | 1 |
| Geczy, CL | 1 |
| Wainwright, BJ | 1 |
| Hume, DA | 1 |
| Padoan, R | 1 |
| Bassotti, A | 1 |
| Seia, M | 1 |
| Ambrosioni, A | 1 |
| Fiori, S | 1 |
| Prandoni, S | 1 |
| Rajnoldi, AC | 1 |
| Giunta, A | 1 |
| Corbetta, C | 1 |
| Hamosh, A | 1 |
| King, TM | 1 |
| Rosenstein, BJ | 1 |
| Corey, M | 1 |
| Levison, H | 1 |
| Durie, P | 1 |
| Tsui, LC | 1 |
| McIntosh, I | 1 |
| Keston, M | 1 |
| Brock, DJ | 1 |
7 other studies available for aspartic acid and Cystic Fibrosis
| Article | Year |
|---|---|
V232D mutation in patients with cystic fibrosis: Not so rare, not so mild.
Topics: Adult; Aged; Amino Acid Substitution; Aspartic Acid; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2018 |
A "SYDE" effect of hierarchical phosphorylation: possible relevance to the cystic fibrosis basic defect.
Topics: Amino Acid Sequence; Aspartic Acid; Casein Kinase II; Consensus Sequence; Cystic Fibrosis; Cystic Fi | 2014 |
The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.
Topics: Amino Acid Motifs; Animals; Aspartic Acid; COS Cells; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2004 |
Identification of a D579G homozygote cystic fibrosis patient with pancreatic sufficiency and minor lung involvement. Mutations in brief no. 221. Online.
Topics: Adult; Amino Acid Substitution; Aspartic Acid; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; F | 1999 |
G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Biomarkers; Bone Marrow Cells; Cell Movement; Cysti | 2000 |
A novel missense mutation (D110E) in exon 4 of CFTR (ABCC7) in a CF infant presenting with hypochloraemic metabolic alkalosis.
Topics: Alkalosis; Amino Acid Substitution; Aspartic Acid; Child, Preschool; Chlorides; Cystic Fibrosis; Cys | 2000 |
Cystic fibrosis patients bearing both the common missense mutation Gly----Asp at codon 551 and the delta F508 mutation are clinically indistinguishable from delta F508 homozygotes, except for decreased risk of meconium ileus.
Topics: Adolescent; Aspartic Acid; Child; Child, Preschool; Codon; Cystic Fibrosis; Cystic Fibrosis Transmem | 1992 |