aspartic acid has been researched along with Colorectal Cancer in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.08) | 18.7374 |
| 1990's | 25 (52.08) | 18.2507 |
| 2000's | 15 (31.25) | 29.6817 |
| 2010's | 6 (12.50) | 24.3611 |
| 2020's | 1 (2.08) | 2.80 |
| Authors | Studies |
|---|---|
| Doubleday, PF; Fornelli, L; Kelleher, NL; Ntai, I | 1 |
| Breder, VV; Gagarin, IM; Mazurenko, NN; Mochal'nikova, VV; Tsyganova, IV | 1 |
| Brünner, N; Bunch, L; Christensen, S; Jensen, AA; Jensen, NF; Pedersen, SF; Pedraz-Cuesta, E; Romer, MU; Stenvang, J | 1 |
| Cai, Z; Chen, H; Cheng, KW; Go, MY; Jin, Y; Kang, W; Li, W; Li, X; Ng, SS; Qian, Y; Sung, JJ; To, KF; Tong, JH; Wong, CC; Wu, JL; Xu, J; Yu, J | 1 |
| Inoue, N; Kasahara, M; Miyaishi, A; Osawa, K; Osawa, Y; Shimada, E; Tabuchi, Y; Takahashi, J; Tanaka, K; Tsutou, A; Yamamoto, M; Yoshida, K | 1 |
| Ciardiello, F; De Luca, A; Morgillo, F; Normanno, N; Tejpar, S; Van Cutsem, E | 1 |
| Armas, ML; Corsino, PE; Jaiswal, AS; Law, BK; Narayan, S; Panda, H | 1 |
| Isa, MR; Ismail, S; Rahman, J; Wan Zurinah, WN; Zulhabri, O | 1 |
| Azuma, T; Hayashi, N; Ikeda, A; Izumi, Y; Kawano, S; Kibi, M; Kobayashi, T; Nishiumi, S; Okuno, T; Takenawa, T; Yoshida, M; Yoshie, T | 1 |
| Chen, JZ; Huang, YF; Mao, C; Tang, JL; Yang, ZY; Zheng, DY | 1 |
| Baron, B; Bleiberg, H; Blijham, GH; Couvreur, ML; De Greve, J; Genicot, B; Jansen, RL; Kok, TC; Nortier, JW; Wagener, T; Wils, J | 1 |
| Allegra, CJ; Benson, AB; Catalano, P; Johnston, PG; O'Dwyer, PJ; Rao, MS | 1 |
| Hwang, YH; Park, SP; Suh, CK | 1 |
| Anselmi, L; Arrigoni, A; Bertario, L; Bonelli, L; Bruzzi, P; Fornasarig, M; Gentile, M; Gismondi, V; Mareni, C; Meta, M; Ponz de Leon, M; Radice, P; Sala, P; Varesco, L; Viel, A | 1 |
| Abbruzzese, JL; Ardalan, B; Balcerzak, SP; Benedetti, JK; Gaynor, ER; Macdonald, JS; Whitehead, RP; Williamson, S | 1 |
| Aronson, M; Cleary, SP; Cotterchio, M; Croitoru, ME; Di Nicola, N; Gallinger, S; Gryfe, R; Knight, J; Manno, M; Redston, M; Selander, T | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Esumi, H; Ogura, T; Suzuki, A | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| O'Dwyer, PJ | 2 |
| Creaven, PJ; Meropol, NJ; Petrelli, NJ | 1 |
| Ardalan, B; Doroshow, JH; Fleming, TR; Holcombe, RF; Leichman, CG; Mangalik, A; Meyers, FJ; Muggia, FM; Tangen, CM; Weiss, GR | 1 |
| Breivik, J; Eriksen, JA; Fossum, B; Gaudernack, G; Gedde-Dahl, T; Spurkland, A; Thorsby, E | 1 |
| Cao, S; Rustum, YM; Spector, T | 1 |
| Ahlgren, JD; Anderson, N; Kemeny, N; Lokich, JJ | 1 |
| Hudes, GR; Kitson, J; Litwin, S; O'Dwyer, PJ; Walczak, J; Watts, P; Weiner, LM | 1 |
| Blomgren, H; Ragnhammar, P | 1 |
| Brennan, J; Greene, F; Hageboutros, A; Hudes, GR; LaCreta, FP; O'Dwyer, PJ | 1 |
| Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H | 1 |
| Bokemeyer, C; Dörken, B; Harstrick, A; Hiddemann, W; Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H | 1 |
| Ardalan, B; Franceschi, D; Jaime, M; Luis, R | 1 |
| Dutrillaux, B; Muleris, M; Poupon, MF; Remvikos, Y; Soulie, P | 1 |
| Brady, F; Brown, G; Harte, RJ; Jones, T; Luthra, SJ; Matthews, JC; O'Reilly, SM; Osman, S; Price, PM; Tilsley, DW | 1 |
| Belt, RJ; Bready, B; Dakhil, SR; Goodwin, JW; Gray, R; Hoff, PM; McGarry, W; Pazdur, R; Royce, ME; Winn, R | 1 |
| Büchele, T; Dempke, W; Grothey, A; Schmoll, HJ | 1 |
| Arrigo, AP; Bruey, JM; Fromentin, A; Garrido, C; Hilpert, S; Paul, C; Solary, E | 1 |
| Arbuck, SG; Benson, AB; Haller, DG; Hines, JD; Manola, J; Mayer, RJ; O'Dwyer, PJ; Ryan, LM; Valone, FH; Wadler, S; Weiner, LM | 1 |
| Krygier, S; Luchtefeld, MA; Senagore, AJ; Thebo, JS | 1 |
| Elsaleh, H; Gnanasampanthan, G; Iacopetta, B; McCaul, K | 1 |
| Harstrick, A; Köhne-Wömpner, CH; Rustum, YM; Schmoll, HJ | 1 |
| Eisenberg, BL; Fowler, WC; Hoffman, JP | 1 |
| Botet, J; Conti, JA; Costa, P; Kemeny, N; Martin, D; McCulloch, W; Niedzwiecki, D; Seiter, K; Wiseberg, J | 1 |
| Costa, P; Kemeny, N; Kurtz, RC; Martin, D; Murray, M; Niedzwiecki, D; Seiter, K; Urmacher, C | 1 |
| Cheson, BD | 1 |
| Goldberg, RM; Krook, JE; Kugler, JW; Laurie, JA; Moertel, CG; O'Connell, MJ; Pfeifle, DM; Rubin, J; Wieand, HS; Windschitl, HE | 1 |
| Comis, RL; Litwin, S; O'Dwyer, PJ; Paul, AR; Walczak, J; Weiner, LM | 1 |
| Colofiore, J; Derby, S; Kemeny, N; Martin, DS; Salvia, B; Sawyer, RC; Schneider, A | 1 |
11 review(s) available for aspartic acid and Colorectal Cancer
| Article | Year |
|---|---|
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Aspartic Acid; Base Sequence; Biomarkers, Tumor; Cetuximab; Codon; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Exons; Genes, ras; Humans; Molecular Sequence Data; Neoplasm Metastasis; Panitumumab; Patient Selection; Point Mutation; ras Proteins; Signal Transduction; Valine | 2009 |
KRAS p.G13D mutation and codon 12 mutations are not created equal in predicting clinical outcomes of cetuximab in metastatic colorectal cancer: a systematic review and meta-analysis.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Aspartic Acid; Cetuximab; Codon; Colorectal Neoplasms; Disease-Free Survival; Female; Glycine; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Treatment Outcome | 2013 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
Biochemical modulation as an approach to reversal of antimetabolite resistance.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Drug Resistance, Multiple; Fluorouracil; Humans; Interferons; Methylthioinosine; Multicenter Studies as Topic; Phosphonoacetic Acid; Purines; Pyrimidines; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Metastatic colorectal cancer: advances in biochemical modulation and new drug development.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; Diarrhea; Digestive System; Drug Administration Schedule; Fluorouracil; Gastrointestinal Agents; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-alpha; Leucovorin; Octreotide; Phosphonoacetic Acid; Prodrugs; Randomized Controlled Trials as Topic; Thymidylate Synthase; Topoisomerase I Inhibitors | 1995 |
Recent advances in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic | 1993 |
How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Liver Neoplasms; Methotrexate; Phosphonoacetic Acid | 1995 |
The dead end of 5-fluorouracil double modulation and promise of continuous infusion schedules in the treatment of metastatic colorectal cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Combined Modality Therapy; Dipyridamole; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Humans; Immunologic Factors; Infusions, Intravenous; Injections, Intravenous; Interferons; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Proteins; Nucleotides; Palliative Care; Phosphonoacetic Acid; Randomized Controlled Trials as Topic; Thymidylate Synthase | 1996 |
Biomodulation of Fluorouracil in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Synergism; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Methotrexate; Phosphonoacetic Acid; Trimetrexate | 1998 |
Where do we stand with 5-fluorouracil?
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chronotherapy; Colorectal Neoplasms; Dipyridamole; Drug Synergism; Fluorouracil; Humans; Interferons; Leucovorin; Levamisole; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Trimetrexate; Zidovudine | 1999 |
Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Interferons; Leucovorin; Methotrexate; Phosphonoacetic Acid | 1992 |
9 trial(s) available for aspartic acid and Colorectal Cancer
| Article | Year |
|---|---|
High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer: a randomised phase II-III trial of the EORTC Gastrointestinal Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome | 2003 |
A phase II pilot study of high-dose 24-hour continuous infusion of 5-FU and leucovorin and low-dose PALA for patients with colorectal cancer: a Southwest Oncology Group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Pilot Projects; Survival Rate; Treatment Outcome | 2004 |
Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.
Topics: Adult; Aged; Aged, 80 and over; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Diarrhea; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Survival Rate | 1995 |
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside (MMPR), and leucovorin in patients with advanced cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Leucovorin; Male; Methylthioinosine; Middle Aged; Phosphonoacetic Acid | 1997 |
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. Results of a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome | 1997 |
Sequential biochemical modulation of fluorouracil with folinic acid, N-phosphonacetyl-L-aspartic acid, and interferon alfa-2a in advanced colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Immunologic Factors; Infusions, Intravenous; Injections, Intravenous; Injections, Subcutaneous; Interferon-alpha; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome | 1999 |
Fluorouracil modulation in colorectal cancer: lack of improvement with N -phosphonoacetyl- l -aspartic acid or oral leucovorin or interferon, but enhanced therapeutic index with weekly 24-hour infusion schedule--an Eastern Cooperative Oncology Group/Cance
Topics: Administration, Oral; Aged; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Prognosis; Recombinant Proteins | 2001 |
A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA)
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Aspartic Acid; Colorectal Neoplasms; Drug Evaluation; Fluorouracil; Humans; Hyperbilirubinemia; Liver Neoplasms; Male; Phosphonoacetic Acid; Prothrombin Time; Retrospective Studies; Serum Albumin; Syndrome; Transaminases | 1991 |
A clinical trial of biochemical modulation of 5-fluorouracil with N-phosphonoacetyl-L-aspartate and thymidine in advanced gastric and anaplastic colorectal cancer.
Topics: Adult; Aged; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine | 1990 |
28 other study(ies) available for aspartic acid and Colorectal Cancer
| Article | Year |
|---|---|
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells.
Topics: Argininosuccinate Synthase; Aspartic Acid; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Humans; Intracellular Signaling Peptides and Proteins; Metabolomics; Mutation; Phosphoenolpyruvate Carboxykinase (ATP); Phosphoenolpyruvate Carboxykinase (GTP); Proteomics; Proto-Oncogene Proteins p21(ras); Signal Transduction | 2021 |
[The frequency and spectrum of KRAS mutations in metastatic colorectal cancer].
Topics: Adult; Aged; Amino Acid Substitution; Aspartic Acid; Colorectal Neoplasms; Female; Glycine; Humans; Incidence; Male; Middle Aged; Mutation; Neoplasm Staging; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Valine | 2013 |
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.
Topics: Amino Acid Transport System X-AG; Antineoplastic Agents; Aspartic Acid; Camptothecin; Cell Death; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Copper; Drug Resistance, Neoplasm; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Gene Expression; Gene Knockdown Techniques; Glutathione; HCT116 Cells; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Protein Transport; Tumor Suppressor Protein p53 | 2015 |
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.
Topics: Adenoma; Adult; Aged; Animals; Aspartic Acid; Biomarkers, Tumor; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Colon; Colorectal Neoplasms; Disease Progression; Female; Humans; Male; Mice; Mice, Nude; Middle Aged; Mitochondrial Membrane Transport Proteins; Mutation; Neoplasm Transplantation; Proto-Oncogene Proteins p21(ras) | 2016 |
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Topics: Aged; Asian People; Aspartic Acid; Case-Control Studies; Colorectal Neoplasms; DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glutamine; Histidine; Humans; Male; Middle Aged; Polymorphism, Genetic; Smoking | 2008 |
Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.
Topics: Aspartic Acid; Colorectal Neoplasms; DNA Repair; Enzyme Inhibitors; Flap Endonucleases; Humans; Models, Molecular; Structure-Activity Relationship | 2009 |
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Topics: Adenine; Adenoma; Adult; Aged; Aged, 80 and over; Aspartic Acid; Carcinoma; Codon; Colorectal Neoplasms; Exons; Female; Genes, ras; Glycine; Guanine; Humans; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational | 2012 |
A novel serum metabolomics-based diagnostic approach for colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Aspartic Acid; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Cystamine; Early Detection of Cancer; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Kynurenine; Logistic Models; Malates; Male; Metabolomics; Middle Aged; Multivariate Analysis; Reference Standards; ROC Curve; Statistics, Nonparametric | 2012 |
Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biomarkers, Tumor; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Interferon alpha-2; Interferon-alpha; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Prognosis; Recombinant Proteins; Retrospective Studies; Survival Rate; Thymidylate Synthase; Treatment Outcome | 2003 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain Neoplasms; Choline; Colorectal Neoplasms; Diagnosis, Differential; Fluorouracil; Humans; Lactic Acid; Leukoencephalopathy, Progressive Multifocal; Levamisole; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Metastasis; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon | 2003 |
Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas.
Topics: Adenine; Adenoma; Adenomatous Polyposis Coli; Adult; Aged; Aspartic Acid; Case-Control Studies; Colorectal Neoplasms; Cysteine; DNA Glycosylases; DNA Mutational Analysis; DNA, Neoplasm; Female; Gene Deletion; Gene Frequency; Germ-Line Mutation; Glycine; Guanine; Humans; Italy; Male; Middle Aged; Tyrosine | 2004 |
Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.
Topics: Adenomatous Polyposis Coli; Aspartic Acid; Base Pair Mismatch; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cysteine; DNA Glycosylases; DNA Mutational Analysis; DNA, Neoplasm; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Glycine; Humans; Loss of Heterozygosity; Ontario; Phenotype; Risk Factors; Tyrosine | 2004 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.
Topics: Amino Acid Sequence; Aspartic Acid; Calcium; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Progression; Enzyme Activation; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phospholipase C gamma; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Repressor Proteins | 2006 |
p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).
Topics: Adenocarcinoma; Amino Acid Sequence; Aspartic Acid; CD4-Positive T-Lymphocytes; CD8 Antigens; Cells, Cultured; Colorectal Neoplasms; Female; Gene Amplification; Genes, ras; Glycine; Humans; Middle Aged; Molecular Sequence Data; Mutation; Peptides; Phenotype; Proto-Oncogene Proteins p21(ras); T-Lymphocytes | 1994 |
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Leucovorin; Neoplasm Transplantation; Phosphonoacetic Acid; Rats; Rats, Inbred F344; Uracil | 1994 |
Preservation of immune effector cell function following administration of a dose-intense 5-fluorouracil-chemotherapy regimen.
Topics: Adenocarcinoma; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Humans; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Killer Cells, Natural; Leukocytes, Mononuclear; Lymphocytes; Monocytes; Phenotype; Phosphonoacetic Acid | 1993 |
Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers.
Topics: Aspartic Acid; Chromosome Aberrations; Colorectal Neoplasms; Drug Resistance; Enzyme Inhibitors; Gene Rearrangement; Humans; Phosphonoacetic Acid; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Tumor, normal tissue, and plasma pharmacokinetic studies of fluorouracil biomodulation with N-phosphonacetyl-L-aspartate, folinic acid, and interferon alfa.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Area Under Curve; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Regional Blood Flow; Stomach Neoplasms; Tomography, Emission-Computed | 1999 |
Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Aspartic Acid; Biopolymers; Caspase 3; Caspase 9; Caspases; Cell Communication; Cell Count; Cell-Free System; Cisplatin; Colorectal Neoplasms; Coumarins; Etoposide; Heat-Shock Proteins; Mice; Molecular Weight; Mutagenesis, Site-Directed; Neoplasm Proteins; Oligopeptides; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 2000 |
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Topics: Aspartic Acid; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Genes, ras; Glycine; Humans; Neoplasm Metastasis; Neoplastic Cells, Circulating; Polymerase Chain Reaction | 2001 |
Ki-ras mutation type and the survival benefit from adjuvant chemotherapy in Dukes' C colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Genes, ras; Humans; Male; Middle Aged; Mutation; Patient Selection; Prognosis; Regression Analysis; Retrospective Studies; Survival Rate; Treatment Outcome | 2001 |
Hepatic resection following systemic chemotherapy for metastatic colorectal carcinoma.
Topics: Aged; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Retrospective Studies; Time Factors | 1992 |
Biochemical modulation of bolus fluorouracil by PALA in patients with advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Injections, Intravenous; Leukocyte Count; Male; Middle Aged; Phosphonoacetic Acid | 1992 |
Clinical trials referral resource. Treatment of advanced colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Phosphonoacetic Acid | 1991 |
Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Phosphonoacetic Acid; Survival Analysis | 1990 |
Biochemical modulation of 5-fluorouracil by PALA.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Evaluation; Drug Synergism; Fluorouracil; Humans; Phosphonoacetic Acid | 1990 |
Phase I trial of N-(phosphonacetyl)-L-aspartate, methotrexate, and 5-fluorouracil with leucovorin rescue in patients with advanced cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; Carcinoma, Squamous Cell; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1989 |