aspartic acid has been researched along with Cognitive Dysfunction in 53 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared with HC, schizophrenia patients had lower cognitive performance, higher methionine concentrations, decreased concentrations of glutamic acid, cysteine, aspartic acid, arginine, the ratio of glutamic acid to gamma-aminobutyric acid (Glu/GABA), and DAT availability in the left caudate nucleus (CN) and putamen." | 4.12 | Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia. ( Chen, YY; Chou, YH; Liu, MN; Yang, BH; Yang, KC, 2022) |
| "The NAA/Cr (N-acetyl aspartate/creatine) of the bilateral hippocampus of the cognitive impairment group was lower than those of both control group of stroke and health (p < 0." | 3.85 | Study on the clinical application of the MRS in the cognitive assessment after stroke. ( Chen, W; Gong, ZK; Sheng, C; Wang, M; Wang, SY; Wang, XX, 2017) |
| "Therefore, effective treatments for aging have not yet been developed, and the establishment of therapeutic strategies has not progressed accordingly." | 1.72 | N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice. ( Izuo, N; Kitazawa, A; Miyanishi, H; Muramatsu, SI; Nitta, A, 2022) |
| "Diagnosis of Parkinson's disease (PD) cognitive impairment at early stages is challenging compared to the stage of PD dementia where functional impairment is apparent and easily diagnosed." | 1.62 | Frontal lobe metabolic alterations characterizing Parkinson's disease cognitive impairment. ( Chaudhary, S; Goyal, V; Jagannathan, NR; Kalaivani, M; Kaloiya, GS; Kumaran, SS; Mehta, N; Sagar, R; Srivastava, AK, 2021) |
| "Thirty-five patients with brain metastases underwent baseline single slice multi-voxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20)." | 1.46 | Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. ( Bulik, M; Burkon, P; Dobiaskova, M; Hynkova, L; Jancalek, R; Kazda, T; Laack, NN; Pospisil, P; Slampa, P, 2017) |
| "SNI mice developed mechanical allodynia and motor coordination impairment 30 days after SNI surgery." | 1.43 | D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice. ( D'Aniello, A; de Bartolomeis, A; de Novellis, V; Guida, F; Iannotta, M; Luongo, L; Maione, S; Marabese, I; Marmo, F; Palazzo, E; Romano, R; Rossi, F; Stella, L; Usiello, A, 2016) |
| "Amnestic mild cognitive impairment (aMCI) is often the prodromal stage to AD." | 1.43 | (1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease. ( Chen, W; Chen, X; Guo, Z; Hou, H; Liu, X; Shen, Y; Wei, F, 2016) |
| "Amnestic mild cognitive impairment (aMCI) has been considered to be a transitional state between healthy aging and very mild Alzheimer's disease (AD)." | 1.42 | [Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy]. ( Akiguchi, I; Shiino, A; Watanabe, T, 2015) |
| "The mild cognitive impairment in Parkinson's disease (PD-MCI) has received increasing attention, of which the diagnosis is challenging." | 1.39 | Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment. ( Gan, R; Huang, B; Huang, Z; Nie, K; Wang, L; Zhang, Y; Zhao, J, 2013) |
| "The diagnosis of mild or questionable Alzheimer's disease (AD) depends on clinical criteria that often leave a margin for doubt." | 1.37 | Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease. ( Andreiuolo, PA; Bottino, CM; de Oliveira-Souza, R; Moll, J; Silveira de Souza, A; Tovar-Moll, F, 2011) |
| "Amnestic mild cognitive impairment (MCI) is highly predictive of Alzheimer's disease but the pace of deterioration varies across patients." | 1.37 | Longitudinal magnetic resonance spectroscopy as marker of cognitive deterioration in mild cognitive impairment. ( Fayed, N; Modrego, PJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 37 (69.81) | 24.3611 |
| 2020's | 16 (30.19) | 2.80 |
| Authors | Studies |
|---|---|
| Shad, KF | 1 |
| Soubra, W | 1 |
| Cordato, DJ | 1 |
| Miyanishi, H | 1 |
| Kitazawa, A | 1 |
| Izuo, N | 1 |
| Muramatsu, SI | 1 |
| Nitta, A | 1 |
| Zhang, J | 1 |
| Zhang, Y | 3 |
| Liu, Y | 2 |
| Niu, X | 1 |
| Gozdas, E | 1 |
| Hinkley, L | 1 |
| Fingerhut, H | 1 |
| Dacorro, L | 1 |
| Gu, M | 1 |
| Sacchet, MD | 1 |
| Hurd, R | 1 |
| Hosseini, SMH | 1 |
| Yang, KC | 1 |
| Chen, YY | 1 |
| Liu, MN | 1 |
| Yang, BH | 1 |
| Chou, YH | 1 |
| Huang, X | 1 |
| Lai, S | 1 |
| Lu, X | 1 |
| Wang, Y | 1 |
| Chen, G | 1 |
| Chen, P | 1 |
| Ye, K | 1 |
| Duan, M | 1 |
| Song, K | 1 |
| Zhong, S | 1 |
| Jia, Y | 1 |
| Levin, O | 1 |
| Vints, WAJ | 1 |
| Ziv, G | 1 |
| Katkutė, G | 1 |
| Kušleikienė, S | 1 |
| Valatkevičienė, K | 1 |
| Sheoran, S | 1 |
| Drozdova-Statkevičienė, M | 1 |
| Gleiznienė, R | 1 |
| Pääsuke, M | 1 |
| Dudonienė, V | 1 |
| Himmelreich, U | 1 |
| Česnaitienė, VJ | 1 |
| Masiulis, N | 1 |
| Morley, KC | 1 |
| Lagopoulos, J | 1 |
| Logge, W | 1 |
| Chitty, K | 1 |
| Moustafa, AA | 1 |
| Haber, PS | 1 |
| Li, S | 1 |
| Yin, C | 1 |
| Zhao, W | 1 |
| Lian, X | 1 |
| Hong, Q | 1 |
| Wong, D | 1 |
| Atiya, S | 1 |
| Fogarty, J | 1 |
| Montero-Odasso, M | 1 |
| Pasternak, SH | 1 |
| Brymer, C | 1 |
| Borrie, MJ | 1 |
| Bartha, R | 1 |
| Chaudhary, S | 1 |
| Kumaran, SS | 1 |
| Goyal, V | 1 |
| Kalaivani, M | 1 |
| Kaloiya, GS | 1 |
| Sagar, R | 1 |
| Mehta, N | 1 |
| Srivastava, AK | 1 |
| Jagannathan, NR | 1 |
| Yesilkaya, UH | 1 |
| Sen, M | 1 |
| Balcioglu, YH | 1 |
| Alirezaei, Z | 1 |
| Amouheidari, A | 1 |
| Hassanpour, M | 1 |
| Davanian, F | 1 |
| Iraji, S | 1 |
| Shokrani, P | 1 |
| Nazem-Zadeh, MR | 1 |
| Ding, Y | 1 |
| Lin, H | 1 |
| Chen, X | 2 |
| Zhu, B | 1 |
| Xu, X | 2 |
| Shen, W | 1 |
| Gao, M | 1 |
| He, N | 1 |
| Ta, D | 1 |
| Ishaque, A | 1 |
| Srivastava, O | 1 |
| Hanstock, C | 1 |
| Seres, P | 1 |
| Eurich, DT | 1 |
| Luk, C | 1 |
| Briemberg, H | 1 |
| Frayne, R | 1 |
| Genge, AL | 1 |
| Graham, SJ | 1 |
| Korngut, L | 1 |
| Zinman, L | 1 |
| Kalra, S | 1 |
| Wang, SY | 1 |
| Wang, M | 1 |
| Wang, XX | 1 |
| Chen, W | 2 |
| Sheng, C | 1 |
| Gong, ZK | 1 |
| Shih, CM | 1 |
| Lai, JJ | 1 |
| Chang, CC | 1 |
| Chen, CS | 1 |
| Yeh, YC | 1 |
| Jaw, TS | 1 |
| Hsu, JS | 1 |
| Li, CW | 1 |
| Waragai, M | 1 |
| Moriya, M | 1 |
| Nojo, T | 1 |
| Piaceri, I | 1 |
| Bessi, V | 1 |
| Matà, S | 1 |
| Polito, C | 1 |
| Tedde, A | 1 |
| Berti, V | 1 |
| Bagnoli, S | 1 |
| Braccia, A | 1 |
| Del Mastio, M | 1 |
| Pignone, AM | 1 |
| Pupi, A | 1 |
| Sorbi, S | 1 |
| Nacmias, B | 1 |
| Reid, MA | 1 |
| Salibi, N | 1 |
| White, DM | 1 |
| Gawne, TJ | 1 |
| Denney, TS | 1 |
| Lahti, AC | 1 |
| Wolfrum, C | 1 |
| Peleg-Raibstein, D | 1 |
| Kroll, JL | 1 |
| Steele, AM | 1 |
| Pinkham, AE | 1 |
| Choi, C | 1 |
| Khan, DA | 1 |
| Patel, SV | 1 |
| Chen, JR | 1 |
| Aslan, S | 1 |
| Sherwood Brown, E | 1 |
| Ritz, T | 1 |
| Alakkas, A | 1 |
| Ellis, RJ | 1 |
| Watson, CW | 1 |
| Umlauf, A | 1 |
| Heaton, RK | 1 |
| Letendre, S | 1 |
| Collier, A | 1 |
| Marra, C | 1 |
| Clifford, DB | 1 |
| Gelman, B | 1 |
| Sacktor, N | 1 |
| Morgello, S | 1 |
| Simpson, D | 1 |
| McCutchan, JA | 1 |
| Kallianpur, A | 1 |
| Gianella, S | 1 |
| Marcotte, T | 1 |
| Grant, I | 1 |
| Fennema-Notestine, C | 1 |
| Weng, YC | 1 |
| Hsiao, IT | 1 |
| Huang, CY | 1 |
| Huang, KL | 1 |
| Liu, CH | 1 |
| Chang, TY | 1 |
| Yen, TC | 1 |
| Lin, KJ | 1 |
| Huang, CC | 1 |
| Liu, T | 1 |
| Li, Z | 1 |
| He, J | 1 |
| Yang, N | 1 |
| Han, D | 1 |
| Li, Y | 1 |
| Tian, X | 1 |
| Liu, H | 1 |
| Manyande, A | 1 |
| Xiang, H | 1 |
| Xu, F | 1 |
| Wang, J | 1 |
| Guo, X | 1 |
| Cai, ZL | 1 |
| Xue, S | 1 |
| Zhou, X | 1 |
| Wu, F | 1 |
| Kantarci, K | 1 |
| Menezes, TL | 1 |
| Andrade-Valença, LP | 1 |
| Valença, MM | 1 |
| Tumati, S | 1 |
| Martens, S | 1 |
| Aleman, A | 1 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Mato Abad, V | 1 |
| Quirós, A | 1 |
| García-Álvarez, R | 1 |
| Loureiro, JP | 1 |
| Alvarez-Linera, J | 1 |
| Frank, A | 1 |
| Hernández-Tamames, JA | 1 |
| Suriyajakryuththana, W | 1 |
| Tuntiyatorn, L | 1 |
| Teepprasarn, N | 1 |
| Sukying, C | 1 |
| Glodzik, L | 1 |
| Sollberger, M | 1 |
| Gass, A | 1 |
| Gokhale, A | 1 |
| Rusinek, H | 1 |
| Babb, JS | 1 |
| Hirsch, JG | 1 |
| Amann, M | 1 |
| Monsch, AU | 1 |
| Gonen, O | 1 |
| Watanabe, T | 1 |
| Shiino, A | 1 |
| Akiguchi, I | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Cheong, JL | 1 |
| Bainbridge, A | 1 |
| Anderson, PJ | 1 |
| Lee, KJ | 1 |
| Burnett, AC | 1 |
| Thompson, DK | 1 |
| Roberts, G | 1 |
| Wood, SJ | 1 |
| Doyle, LW | 1 |
| Robertson, NJ | 1 |
| Meng, N | 1 |
| Shi, S | 1 |
| Su, Y | 1 |
| Palazzo, E | 1 |
| Luongo, L | 1 |
| Guida, F | 1 |
| Marabese, I | 1 |
| Romano, R | 1 |
| Iannotta, M | 1 |
| Rossi, F | 1 |
| D'Aniello, A | 1 |
| Stella, L | 1 |
| Marmo, F | 1 |
| Usiello, A | 1 |
| de Bartolomeis, A | 1 |
| Maione, S | 1 |
| de Novellis, V | 1 |
| Guo, Z | 1 |
| Liu, X | 1 |
| Hou, H | 1 |
| Wei, F | 1 |
| Shen, Y | 1 |
| Kim, JE | 1 |
| Kim, GH | 1 |
| Hwang, J | 1 |
| Kim, JY | 1 |
| Renshaw, PF | 1 |
| Yurgelun-Todd, DA | 1 |
| Kim, B | 1 |
| Kang, I | 1 |
| Jeon, S | 1 |
| Ma, J | 1 |
| Lyoo, IK | 1 |
| Yoon, S | 1 |
| Pospisil, P | 1 |
| Kazda, T | 1 |
| Hynkova, L | 1 |
| Bulik, M | 1 |
| Dobiaskova, M | 1 |
| Burkon, P | 1 |
| Laack, NN | 1 |
| Slampa, P | 1 |
| Jancalek, R | 1 |
| Choudhary, AK | 1 |
| Lee, YY | 1 |
| Foy, CM | 1 |
| Daly, EM | 1 |
| Glover, A | 1 |
| O'Gorman, R | 1 |
| Simmons, A | 1 |
| Murphy, DG | 1 |
| Lovestone, S | 1 |
| Wang, T | 1 |
| Xiao, S | 1 |
| Li, X | 1 |
| Ding, B | 1 |
| Ling, H | 1 |
| Chen, K | 1 |
| Fang, Y | 1 |
| Yang, H | 1 |
| Lyutvinskiy, Y | 1 |
| Soininen, H | 1 |
| Zubarev, RA | 1 |
| Jessen, F | 1 |
| Lewczuk, P | 1 |
| Gür, O | 1 |
| Block, W | 1 |
| Ende, G | 1 |
| Frölich, L | 1 |
| Hammen, T | 1 |
| Arlt, S | 1 |
| Kornhuber, J | 1 |
| Kucinski, T | 1 |
| Popp, J | 1 |
| Peters, O | 1 |
| Maier, W | 1 |
| Träber, F | 1 |
| Wiltfang, J | 1 |
| Fayed, N | 2 |
| Modrego, PJ | 2 |
| Rojas-Salinas, G | 1 |
| Aguilar, K | 1 |
| Walecki, J | 1 |
| Barcikowska, M | 1 |
| Ćwikła, JB | 1 |
| Gabryelewicz, T | 1 |
| Silveira de Souza, A | 1 |
| de Oliveira-Souza, R | 1 |
| Moll, J | 1 |
| Tovar-Moll, F | 1 |
| Andreiuolo, PA | 1 |
| Bottino, CM | 1 |
| Lim, TS | 1 |
| Hong, YH | 1 |
| Choi, JY | 1 |
| Kim, HS | 1 |
| Moon, SY | 1 |
| Pagonabarraga, J | 1 |
| Gómez-Ansón, B | 1 |
| Rotger, R | 1 |
| Llebaria, G | 1 |
| García-Sánchez, C | 1 |
| Pascual-Sedano, B | 1 |
| Gironell, A | 1 |
| Delfino, M | 1 |
| Ruscalleda, J | 1 |
| Kulisevsky, J | 1 |
| Nie, K | 1 |
| Huang, B | 1 |
| Wang, L | 2 |
| Zhao, J | 1 |
| Huang, Z | 1 |
| Gan, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis[NCT02405182] | 145 participants (Actual) | Observational | 2014-09-30 | Completed | |||
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspartic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Magnetic resonance spectroscopy in mild cognitive impairment: systematic review and meta-analysis.
Topics: Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Humans; Inositol; Magnetic Resonance Spectr | 2013 |
Neurophysiological symptoms and aspartame: What is the connection?
Topics: Affect; Animals; Aspartame; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Models, Animal; Dop | 2018 |
50 other studies available for aspartic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.
Topics: Acoustic Stimulation; Afferent Pathways; Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Cerebra | 2022 |
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice.
Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Cognition; Cognitive Dysfunction; Hippocampus; Mi | 2022 |
Naringenin Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia by Inhibiting Hippocampal Oxidative Stress and Inflammatory Response and Promoting N-Methyl-D-Aspartate Receptor Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Cognitive Dysfunction; Dementia, Vascular; Disease | 2022 |
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition; Cognitive Dysfunction; Creatine; Glutamic Acid; H | 2022 |
Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia.
Topics: Amino Acids; Arginine; Aspartic Acid; Cognitive Dysfunction; Corpus Striatum; Cysteine; Dopamine; Do | 2022 |
Cognitive dysfunction and neurometabolic alternations in major depressive disorder with gastrointestinal symptoms.
Topics: Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Depressive Disorder, Major; Humans; Proton | 2023 |
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P | 2023 |
Brain N-Acetyl Aspartate and associations with cognitive impairment in alcohol dependent patients.
Topics: Adult; Aged; Alcoholism; Aspartic Acid; Brain Chemistry; Cognitive Dysfunction; Female; Humans; Magn | 2020 |
Application of Hydrogen Proton Magnetic Resonance Technology Combined with Brain Neurometabolite Analysis in the Treatment of Cognitive Impairment Caused by Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Aspartic Acid; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Female; Humans; Hydrog | 2020 |
Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Diffusion Tensor I | 2020 |
Frontal lobe metabolic alterations characterizing Parkinson's disease cognitive impairment.
Topics: Aspartic Acid; Brain; Cognitive Dysfunction; Creatine; Frontal Lobe; Gray Matter; Humans; Magnetic R | 2021 |
COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; COVID-19; Glutamic Acid; Humans; Magnetic Resonance Spe | 2021 |
Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.
Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Cognitive Dysfunction; Creatine; Early Diagnosis; | 2021 |
Comprehensive metabolomics profiling reveals common metabolic alterations underlying the four major non-communicable diseases in treated HIV infection.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Atherosclerosis; Cognitive Dysfunction; Female; Glu | 2021 |
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progressio | 2021 |
Study on the clinical application of the MRS in the cognitive assessment after stroke.
Topics: Aspartic Acid; Cognition; Cognition Disorders; Cognitive Dysfunction; Creatine; Hippocampus; Humans; | 2017 |
Comparison of LCModel and SAGE in Analysis of Brain Metabolite Concentrations-A study of Patients with Mild Cognitive Impairment.
Topics: Aspartic Acid; Brain; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Humans; Magnet | 2017 |
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Diseas | 2017 |
Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; C9orf72 Protein; Cognitive Dysfunction; DNA Muta | 2018 |
7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus C | 2019 |
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice.
Topics: Animals; Aspartic Acid; Avoidance Learning; Brain Chemistry; Cognitive Dysfunction; Diet, High-Fat; | 2019 |
Hippocampal metabolites in asthma and their implications for cognitive function.
Topics: Adolescent; Adult; Aspartic Acid; Asthma; Cognition; Cognitive Dysfunction; Creatine; Female; Glutam | 2018 |
White matter damage, neuroinflammation, and neuronal integrity in HAND.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2019 |
Progress of Brain Amyloid Deposition in Familial Alzheimer's Disease with Taiwan D678H APP Mutation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P | 2018 |
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; F | 2020 |
Proxies of cognitive reserve and their effects on neuropsychological performance in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Cognitive Dysfunction; Cognitive Reserv | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
The partial volume effect in the quantification of 1H magnetic resonance spectroscopy in Alzheimer's disease and aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Cogni | 2014 |
Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2014 |
Global N-acetylaspartate in normal subjects, mild cognitive impairment and Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain; Cognitive Dysfunction; | 2015 |
[Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy].
Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; | 2015 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents.
Topics: Adolescent; Aspartic Acid; Australia; Brain; Cell Membrane; Choline; Cognition; Cognition Disorders; | 2016 |
Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase.
Topics: Aged; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Creatine; Female; Hippocampus; Humans; Male; | 2016 |
D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice.
Topics: Animals; Aspartic Acid; Cognitive Dysfunction; Disks Large Homolog 4 Protein; Homer Scaffolding Prot | 2016 |
(1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Dominance, Cerebra | 2016 |
Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users.
Topics: Adolescent; Amphetamine-Related Disorders; Aspartic Acid; Brain; Case-Control Studies; Cognitive Dys | 2018 |
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.
Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Cognitive Dysfunction; Cranial Irradiation; Female; Foll | 2017 |
Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2011 |
Using proton magnetic resonance spectroscopy to identify mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Cognitive Dysfunction; | 2012 |
Alzheimer's disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins.
Topics: Alzheimer Disease; Aspartic Acid; Blood Proteins; Cognitive Dysfunction; Female; Humans; Male; Mass | 2011 |
Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognitive Dysfunction; De | 2011 |
Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; | 2011 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; | 2011 |
Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dys | 2011 |
Longitudinal magnetic resonance spectroscopy as marker of cognitive deterioration in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cognitive Dysfunction; Creatine; F | 2011 |
Functional investigation of bilateral posterior cingulate gyri using multivoxel MR spectroscopy.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dys | 2012 |
Spectroscopic changes associated with mild cognitive impairment and dementia in Parkinson's disease.
Topics: Aged, 80 and over; Aspartic Acid; Brain Chemistry; Cognition; Cognitive Dysfunction; Data Interpreta | 2012 |
Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment.
Topics: Aged; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Choline; Cognitive Dysfunction; Early Diagn | 2013 |