aspartic acid has been researched along with Citrullinemia in 10 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Citrullinemia: A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that ASS1 functions as a tumor suppressor in breast cancer, and the pesticide spinosyn A (SPA) and its derivative LM-2I suppress breast tumor cell proliferation and growth by binding to and activating ASS1." | 4.02 | Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor. ( Cao, D; Chen, C; Chen, L; Chen, X; Hu, X; Kong, F; Li, J; Li, X; Liu, O; Liu, S; Luo, J; Luo, T; Luo, W; Luo, Z; Ma, D; Ming, Z; Peng, K; Wen, M; Xia, L; Xie, Y; Xu, N; Yang, C; Yi, W; Zou, Z, 2021) |
| "Citrullinemia type 1 is an autosomal-recessive urea cycle disorder caused by mutations in the ASS1 gene and characterised by increased plasma citrulline concentrations." | 3.83 | Kinetic mutations in argininosuccinate synthetase deficiency: characterisation and in vitro correction by substrate supplementation. ( Diez-Fernandez, C; Fingerhut, R; Gemperle, C; Häberle, J; Rüfenacht, V; Wellauer, O, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tavoulari, S | 1 |
| Lacabanne, D | 1 |
| Thangaratnarajah, C | 1 |
| Kunji, ERS | 1 |
| Yau, WW | 1 |
| Chen, GB | 1 |
| Zhou, J | 1 |
| Francisco, JC | 1 |
| Thimmukonda, NK | 1 |
| Li, S | 1 |
| Singh, BK | 1 |
| Yen, PM | 1 |
| Zou, Z | 1 |
| Hu, X | 1 |
| Luo, T | 1 |
| Ming, Z | 1 |
| Chen, X | 1 |
| Xia, L | 1 |
| Luo, W | 1 |
| Li, J | 1 |
| Xu, N | 1 |
| Chen, L | 1 |
| Cao, D | 1 |
| Wen, M | 1 |
| Kong, F | 1 |
| Peng, K | 1 |
| Xie, Y | 1 |
| Li, X | 1 |
| Ma, D | 1 |
| Yang, C | 1 |
| Chen, C | 1 |
| Yi, W | 1 |
| Liu, O | 1 |
| Liu, S | 1 |
| Luo, J | 1 |
| Luo, Z | 1 |
| Saheki, T | 4 |
| Moriyama, M | 3 |
| Kuroda, E | 1 |
| Funahashi, A | 1 |
| Yasuda, I | 1 |
| Setogawa, Y | 1 |
| Gao, Q | 1 |
| Ushikai, M | 1 |
| Furuie, S | 1 |
| Yamamura, KI | 1 |
| Takano, K | 1 |
| Nakamura, Y | 2 |
| Eto, K | 1 |
| Kadowaki, T | 1 |
| Sinasac, DS | 3 |
| Furukawa, T | 1 |
| Horiuchi, M | 3 |
| Tai, YH | 1 |
| Rabinovich, S | 1 |
| Adler, L | 1 |
| Yizhak, K | 1 |
| Sarver, A | 1 |
| Silberman, A | 1 |
| Agron, S | 1 |
| Stettner, N | 1 |
| Sun, Q | 1 |
| Brandis, A | 1 |
| Helbling, D | 1 |
| Korman, S | 1 |
| Itzkovitz, S | 1 |
| Dimmock, D | 1 |
| Ulitsky, I | 1 |
| Nagamani, SC | 1 |
| Ruppin, E | 1 |
| Erez, A | 1 |
| Diez-Fernandez, C | 1 |
| Wellauer, O | 1 |
| Gemperle, C | 1 |
| Rüfenacht, V | 1 |
| Fingerhut, R | 1 |
| Häberle, J | 1 |
| Jalil, MA | 1 |
| Begum, L | 1 |
| Li, MX | 2 |
| Iijima, M | 2 |
| Robinson, BH | 1 |
| Kobayashi, K | 3 |
| Tsui, LC | 2 |
| Kannan, Y | 1 |
| Tanaka, M | 1 |
| Fiermonte, G | 1 |
| Soon, D | 1 |
| Chaudhuri, A | 1 |
| Paradies, E | 1 |
| Lee, PJ | 1 |
| Krywawych, S | 1 |
| Palmieri, F | 1 |
| Lachmann, RH | 1 |
2 reviews available for aspartic acid and Citrullinemia
| Article | Year |
|---|---|
Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency.
Topics: Adult; Aspartic Acid; Calcium; Citrullinemia; Glutamates; Humans; Infant, Newborn; Mitochondrial Mem | 2022 |
[Molecular basis of citrin deficiency].
Topics: Aspartic Acid; Calcium; Calcium-Binding Proteins; Cholestasis, Intrahepatic; Chromosome Mapping; Cit | 2004 |
8 other studies available for aspartic acid and Citrullinemia
| Article | Year |
|---|---|
Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency.
Topics: Aspartic Acid; Citrullinemia; Fatty Acids; Glycolysis; Hepatocytes; Humans; Hyperammonemia; Malates; | 2023 |
Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor.
Topics: Adult; Aged; Animals; Argininosuccinate Synthase; Aspartic Acid; Breast; Breast Neoplasms; Cell Line | 2021 |
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.
Topics: Amino Acids; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Citrulline; Citrullinemia; Disease | 2019 |
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
Topics: Animals; Argininosuccinate Synthase; Aspartate Carbamoyltransferase; Aspartic Acid; Calcium-Binding | 2015 |
Kinetic mutations in argininosuccinate synthetase deficiency: characterisation and in vitro correction by substrate supplementation.
Topics: Argininosuccinate Synthase; Aspartic Acid; Catalytic Domain; Citrulline; Citrullinemia; Humans; Kine | 2016 |
Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.
Topics: Amino Acids; Ammonia; Animals; Argininosuccinate Synthase; Aspartic Acid; Base Sequence; Citrullinem | 2004 |
Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice.
Topics: Amino Acids; Ammonia; Animals; Anticoagulants; Aspartic Acid; Calcium-Binding Proteins; Citric Acid; | 2006 |
An adult with type 2 citrullinemia presenting in Europe.
Topics: Adult; Aspartic Acid; Biological Transport, Active; Citrullinemia; Europe; Fatal Outcome; Glutamic A | 2008 |