aspartic acid has been researched along with Chemical Dependence in 22 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Various molecules are involved in drug addiction induced by drugs of abuse." | 2.49 | [The role of a molecule associated with drug dependence, shati/nat8l]. ( Hori, E; Iegaki, N; Miyamoto, Y; Muramatsu, S; Nabeshima, T; Nishijo, H; Nitta, A; Saika, E; Sumi, K; Uno, K, 2013) |
| " Chronic use has been suggested to lead to persistent schizophrenia-like neurobiological changes." | 1.40 | Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users. ( Fam, J; Furby, H; Howes, OD; Hughes, E; Morgan, C; Pepper, F; Stone, JM, 2014) |
| "Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI)." | 1.40 | Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders. ( Acheson, A; Bray, BC; Dougherty, DM; Fox, PT; Gaston, F; Hong, LE; Kochunov, P; Lovallo, WR; Mathias, CW; McGuire, S; Rowland, LM; Wijtenburg, SA; Wright, SN, 2014) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stone, JM | 1 |
| Pepper, F | 1 |
| Fam, J | 1 |
| Furby, H | 1 |
| Hughes, E | 1 |
| Morgan, C | 1 |
| Howes, OD | 1 |
| Howells, FM | 1 |
| Uhlmann, A | 1 |
| Temmingh, H | 1 |
| Sinclair, H | 1 |
| Meintjes, E | 1 |
| Wilson, D | 1 |
| Stein, DJ | 1 |
| Acheson, A | 2 |
| Wijtenburg, SA | 1 |
| Rowland, LM | 2 |
| Bray, BC | 1 |
| Gaston, F | 1 |
| Mathias, CW | 2 |
| Fox, PT | 1 |
| Lovallo, WR | 1 |
| Wright, SN | 2 |
| Hong, LE | 2 |
| McGuire, S | 1 |
| Kochunov, P | 2 |
| Dougherty, DM | 2 |
| Miyamoto, Y | 1 |
| Saika, E | 1 |
| Hori, E | 1 |
| Iegaki, N | 1 |
| Sumi, K | 1 |
| Nabeshima, T | 1 |
| Muramatsu, S | 1 |
| Nishijo, H | 1 |
| Uno, K | 1 |
| Nitta, A | 1 |
| Tagamets, MA | 1 |
| Winkler, A | 1 |
| Cowan, RL | 2 |
| Joers, JM | 1 |
| Dietrich, MS | 1 |
| Licata, SC | 1 |
| Renshaw, PF | 2 |
| Lin, K | 1 |
| Taylor, MJ | 3 |
| Heaton, R | 1 |
| Franklin, D | 1 |
| Jernigan, T | 1 |
| Fennema-Notestine, C | 1 |
| McCutchan, A | 1 |
| Atkinson, JH | 1 |
| Ellis, RJ | 1 |
| McArthur, J | 1 |
| Morgello, S | 1 |
| Simpson, D | 1 |
| Collier, AC | 1 |
| Marra, C | 1 |
| Gelman, B | 1 |
| Clifford, D | 1 |
| Grant, I | 3 |
| Letendre, SL | 1 |
| Schweinsburg, BC | 2 |
| Alhassoon, OM | 2 |
| Brown, GG | 1 |
| Gongvatana, A | 1 |
| Daumann, J | 1 |
| Fischermann, T | 1 |
| Pilatus, U | 1 |
| Thron, A | 1 |
| Moeller-Hartmann, W | 1 |
| Gouzoulis-Mayfrank, E | 1 |
| Arias, A | 1 |
| Feinn, R | 1 |
| Kranzler, HR | 1 |
| Bolo, NR | 1 |
| Dietrich, M | 1 |
| Haga, E | 1 |
| Lukas, SE | 1 |
| Daunderer, M | 1 |
| Chang, L | 1 |
| Ernst, T | 1 |
| Grob, CS | 1 |
| Poland, RE | 1 |
| Videen, JS | 1 |
| Obergriesser, T | 1 |
| Ende, G | 1 |
| Braus, DF | 1 |
| Henn, FA | 1 |
| Reneman, L | 1 |
| Majoie, CB | 1 |
| Flick, H | 1 |
| den Heeten, GJ | 1 |
| Iwata, H | 1 |
| Matsuda, T | 1 |
| Yamagami, S | 1 |
| Hirata, Y | 1 |
| Baba, A | 1 |
| Olbrich, R | 1 |
| Watzl, H | 1 |
| Völter, M | 1 |
| Siedow, H | 1 |
| McCaslin, PP | 2 |
| Morgan, WW | 2 |
| Davies, SN | 1 |
| Martin, D | 1 |
| Millar, JD | 1 |
| Aram, JA | 1 |
| Church, J | 1 |
| Lodge, D | 1 |
3 reviews available for aspartic acid and Chemical Dependence
| Article | Year |
|---|---|
[The role of a molecule associated with drug dependence, shati/nat8l].
Topics: Acetyltransferases; Animals; Aspartic Acid; Behavior, Animal; Brain; Humans; Methamphetamine; Substa | 2013 |
Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.
Topics: Alcoholism; Animals; Appetite Stimulants; Aspartic Acid; Brain; Choline; Cocaine; Creatine; Glutamic | 2010 |
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.
Topics: Alcoholism; Asparagine; Aspartic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Po | 2006 |
1 trial available for aspartic acid and Chemical Dependence
| Article | Year |
|---|---|
[Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study].
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Brain Damage, Chronic; Double-Blind Method; Huma | 1991 |
18 other studies available for aspartic acid and Chemical Dependence
| Article | Year |
|---|---|
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users.
Topics: Adult; Aspartic Acid; Brain; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance | 2014 |
(1)H-magnetic resonance spectroscopy ((1)H-MRS) in methamphetamine dependence and methamphetamine induced psychosis.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamine; Humans; Inositol; Mag | 2014 |
Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.
Topics: Adolescent; Anisotropy; Aspartic Acid; Brain; Child; Choline; Diffusion Tensor Imaging; Family; Fema | 2014 |
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task.
Topics: Adolescent; Aspartic Acid; Brain Mapping; Child; Corpus Striatum; Executive Function; Family; Female | 2015 |
N-acetylaspartate (NAA) correlates inversely with cannabis use in a frontal language processing region of neocortex in MDMA (Ecstasy) polydrug users: a 3 T magnetic resonance spectroscopy study.
Topics: Amphetamine-Related Disorders; Aspartic Acid; Biomarkers; Brain Chemistry; Female; Hallucinogens; Hu | 2009 |
Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
Topics: Adult; Aspartic Acid; Brain Injuries; Cognition Disorders; Depression; Executive Function; Female; H | 2011 |
Hepatitis C virus infection is associated with reduced white matter N-acetylaspartate in abstinent methamphetamine users.
Topics: Adult; Aspartic Acid; Brain; Female; Hepatitis C; Humans; Magnetic Resonance Imaging; Male; Methamph | 2004 |
Proton magnetic resonance spectroscopy in ecstasy (MDMA) users.
Topics: Adult; Aspartic Acid; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; N-Methyl-3,4-met | 2004 |
Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users.
Topics: Adolescent; Adult; Amphetamines; Analgesics, Opioid; Aspartic Acid; Cannabis; Cocaine; Female; Hallu | 2007 |
[Lithium aspartate in drug dependence].
Topics: Adult; Alcoholism; Aspartic Acid; Bipolar Disorder; Female; Humans; Lithium; Male; Middle Aged; Subs | 1982 |
Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Ha | 1999 |
MR spectroscopy in HIV and stimulant dependence HNRC Group. HIV Neurobehavioral Research Center.
Topics: Adult; Aspartic Acid; Brain; Caudate Nucleus; Female; Gyrus Cinguli; HIV Infections; Humans; Magneti | 2000 |
Hippocampal 1H-MRSI in ecstasy users.
Topics: Adult; Aspartic Acid; Brain Chemistry; Case-Control Studies; Choline; Creatine; Hippocampus; Humans; | 2001 |
Reduced N-acetylaspartate levels in the frontal cortex of 3,4-methylenedioxymethamphetamine (Ecstasy) users: preliminary results.
Topics: Adult; Aspartic Acid; Choline; Creatine; Frontal Lobe; Hallucinogens; Humans; Magnetic Resonance Spe | 2002 |
Changes of taurine content in the brain tissue of barbiturate-dependent rats.
Topics: Animals; Aspartic Acid; Barbiturates; Brain Chemistry; gamma-Aminobutyric Acid; Glutamates; Humans; | 1978 |
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
Topics: Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Dose-Response Relationship, | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniq | 1988 |