aspartic acid has been researched along with Cataract in 42 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have demonstrated that asparagine-143 of gammaS crystallin is preferentially deamidated in human cataractous lenses." | 7.71 | Mechanism of asparagine deamidation during human senile cataractogenesis. ( Boyle, D; Fujii, N; Takemoto, L, 2001) |
| "Previous studies have demonstrated that asparagine-143 of gammaS crystallin is preferentially deamidated in human cataractous lenses." | 3.71 | Mechanism of asparagine deamidation during human senile cataractogenesis. ( Boyle, D; Fujii, N; Takemoto, L, 2001) |
| "Cataract is the leading cause of visual impairment globally." | 1.62 | Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin. ( He, WW; Lu, Y; Qi, J; Zhang, KK; Zhu, XJ, 2021) |
| "Cataracts are caused by clouding of the eye lens and may lead to partial or total loss of vision." | 1.38 | A rapid, comprehensive liquid chromatography-mass spectrometry (LC-MS)-based survey of the Asp isomers in crystallins from human cataract lenses. ( Fujii, N; Sakaue, H; Sasaki, H, 2012) |
| "Congenital cataract is both a clinically and genetically heterogeneous lens disorder." | 1.37 | A novel mutation in the GJA3 (connexin46) gene is associated with autosomal dominant congenital nuclear cataract in a Chinese family. ( Fu, Y; Jia, X; Liu, G; Lu, X; Wang, X; Xing, B; Yang, G; Yu, H; Zhao, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (28.57) | 18.7374 |
| 1990's | 7 (16.67) | 18.2507 |
| 2000's | 6 (14.29) | 29.6817 |
| 2010's | 14 (33.33) | 24.3611 |
| 2020's | 3 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Ha, S | 2 |
| Kinouchi, T | 2 |
| Fujii, N | 17 |
| Magami, K | 1 |
| Hachiya, N | 1 |
| Morikawa, K | 1 |
| Takata, T | 7 |
| Zhu, XJ | 2 |
| Zhang, KK | 2 |
| He, WW | 2 |
| Qi, J | 1 |
| Lu, Y | 3 |
| Remø, SC | 1 |
| Hevrøy, EM | 1 |
| Breck, O | 1 |
| Olsvik, PA | 1 |
| Waagbø, R | 1 |
| Du, Y | 1 |
| Hooi, M | 1 |
| Kim, I | 1 |
| Isoyama, M | 1 |
| Suzuki, M | 1 |
| Matsubara, T | 1 |
| Nakamura-Hirota, T | 1 |
| Jin, H | 1 |
| Zhu, B | 1 |
| Liu, X | 1 |
| Jin, J | 1 |
| Zou, H | 1 |
| Garringer, HJ | 1 |
| Murrell, J | 1 |
| Sammeta, N | 1 |
| Gnezda, A | 1 |
| Ghetti, B | 1 |
| Vidal, R | 1 |
| Wang, H | 1 |
| Zhang, T | 1 |
| Wu, D | 1 |
| Zhang, J | 1 |
| Maeda, H | 1 |
| Sakaue, H | 2 |
| Nirasawa, S | 1 |
| Takahashi, S | 1 |
| Sasaki, H | 2 |
| Aki, K | 1 |
| Yang, G | 1 |
| Xing, B | 1 |
| Liu, G | 1 |
| Lu, X | 2 |
| Jia, X | 1 |
| Wang, X | 1 |
| Yu, H | 1 |
| Fu, Y | 1 |
| Zhao, J | 1 |
| Wang, L | 1 |
| Luo, Y | 1 |
| Wen, W | 1 |
| Zhang, S | 1 |
| Hooi, MY | 1 |
| Raftery, MJ | 1 |
| Truscott, RJ | 1 |
| Takeuchi, N | 1 |
| Tezuka, T | 1 |
| Kuge, K | 1 |
| Kamei, A | 1 |
| Saito, T | 1 |
| Addison, PK | 1 |
| Berry, V | 1 |
| Holden, KR | 1 |
| Espinal, D | 1 |
| Rivera, B | 1 |
| Su, H | 1 |
| Srivastava, AK | 1 |
| Bhattacharya, SS | 1 |
| Pauli, S | 1 |
| Söker, T | 1 |
| Klopp, N | 1 |
| Illig, T | 1 |
| Engel, W | 1 |
| Graw, J | 1 |
| Oishi, M | 1 |
| Fujii, S | 1 |
| Takahashi, K | 1 |
| Masters, PM | 3 |
| Kodama, T | 1 |
| Mizobuchi, M | 1 |
| Takeda, R | 1 |
| Torikai, H | 1 |
| Shinomiya, H | 1 |
| Ohashi, Y | 1 |
| Carter, DA | 1 |
| McFadden, PN | 1 |
| Körkkö, J | 1 |
| Ritvaniemi, P | 1 |
| Haataja, L | 1 |
| Kääriäinen, H | 1 |
| Kivirikko, KI | 1 |
| Prockop, DJ | 1 |
| Ala-Kokko, L | 1 |
| Lee, SM | 1 |
| Lin, SY | 1 |
| Cheng, CL | 1 |
| Liang, RC | 1 |
| Takemoto, LJ | 1 |
| Matsumoto, S | 2 |
| Hiroki, K | 2 |
| Boyle, D | 2 |
| Akaboshi, M | 1 |
| Takemoto, L | 3 |
| Heinitz, M | 1 |
| Bada, JL | 2 |
| Zigler, JS | 2 |
| Garner, WH | 1 |
| Spector, A | 1 |
| Kosanović, M | 1 |
| Cupak, K | 1 |
| Emmons, T | 1 |
| Granstrom, D | 1 |
| D'Aniello, A | 1 |
| D'Onofrio, G | 1 |
| Pischetola, M | 1 |
| van den Oetelaar, PJ | 1 |
| Hoenders, HJ | 1 |
| Tamanoi, I | 1 |
| Joshima, H | 1 |
| Kashima, M | 1 |
| Harada, K | 1 |
| Baron, WS | 1 |
| Rowe, VD | 1 |
| Zigler, S | 1 |
| Andersen, AE | 1 |
| Sidbury, JB | 1 |
| Guroff, G | 1 |
| Harris, JE | 1 |
| Gruber, L | 1 |
| Maraini, G | 1 |
| Carta, F | 1 |
| Pescatori, A | 1 |
| Prosperi, L | 1 |
1 review available for aspartic acid and Cataract
| Article | Year |
|---|---|
Isomerization of aspartyl residues in crystallins and its influence upon cataract.
Topics: Aging; Amino Acid Sequence; Animals; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens, | 2016 |
41 other studies available for aspartic acid and Cataract
| Article | Year |
|---|---|
Age-related isomerization of Asp in human immunoglobulin G kappa chain.
Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Cataract; Chromatography, Liquid; Humans; Immunoglobu | 2020 |
Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide.
Topics: Aging; Alanine; alpha-Crystallin A Chain; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Asp | 2021 |
Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin.
Topics: Aged; Aging; Aspartic Acid; Cataract; Cell Nucleus; Crystallins; Female; Humans; Isomerism; Lens, Cr | 2021 |
Lens metabolomic profiling as a tool to understand cataractogenesis in Atlantic salmon and rainbow trout reared at optimum and high temperature.
Topics: Amino Acids; Animals; Aspartic Acid; Carbohydrate Metabolism; Cataract; Fish Diseases; Glutathione; | 2017 |
Racemization at the Asp 58 residue in αA-crystallin from the lens of high myopic cataract patients.
Topics: Aged; Aspartic Acid; Cataract; Crystallins; Female; Humans; Lens, Crystalline; Male; Myopia; Stereoi | 2018 |
Identification of ᴅ-amino acid-containing peptides in human serum.
Topics: Adult; Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; Cataract; Chromatography, Liquid; | 2017 |
Negative charge at aspartate 151 is important for human lens αA-crystallin stability and chaperone function.
Topics: Aged; Aged, 80 and over; alpha-Crystallin A Chain; Aspartic Acid; Cataract; Chromatography, High Pre | 2019 |
Metabolic characterization of diabetic retinopathy: An
Topics: Aged; Alanine; Antioxidants; Aqueous Humor; Area Under Curve; Aspartic Acid; Cataract; Diabetic Reti | 2019 |
Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Cataract; Cerebellar Ataxia; Deafness; | 2013 |
A novel beaded filament structural protein 1 (BFSP1) gene mutation associated with autosomal dominant congenital cataract in a Chinese family.
Topics: Adult; Amino Acid Sequence; Amino Acid Substitution; Animals; Asian People; Asparagine; Aspartic Aci | 2013 |
Rapid survey of four Asp isomers in disease-related proteins by LC-MS combined with commercial enzymes.
Topics: Aged, 80 and over; Aspartic Acid; Cataract; Chromatography, Liquid; Crystallins; Humans; Lens, Cryst | 2015 |
Isomerization of Asp residues plays an important role in αA-crystallin dissociation.
Topics: Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract; Chromatogr | 2016 |
A novel mutation in the GJA3 (connexin46) gene is associated with autosomal dominant congenital nuclear cataract in a Chinese family.
Topics: Amino Acid Sequence; Asian People; Asparagine; Aspartic Acid; Base Sequence; Cataract; Chromosomes, | 2011 |
Another evidence for a D47N mutation in GJA8 associated with autosomal dominant congenital cataract.
Topics: Asian People; Asparagine; Aspartic Acid; Case-Control Studies; Cataract; Connexin 26; Connexins; DNA | 2011 |
A rapid, comprehensive liquid chromatography-mass spectrometry (LC-MS)-based survey of the Asp isomers in crystallins from human cataract lenses.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Cataract; Chromatography, Liquid; Crystallins; Female; Human | 2012 |
Accelerated aging of Asp 58 in αA crystallin and human cataract formation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract | 2013 |
Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats.
Topics: Aging; alpha-Crystallin A Chain; Animals; Aspartic Acid; Cataract; Disease Models, Animal; Humans; I | 2004 |
A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family.
Topics: Aspartic Acid; Cataract; Chromosome Mapping; Connexins; Female; Genes, Dominant; Genetic Linkage; Gu | 2006 |
Mutation analysis in a German family identified a new cataract-causing allele in the CRYBB2 gene.
Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; beta-Crystallin B Chain; Cataract; Child | 2007 |
[An eye-lotion of aspartate upon senile cataract].
Topics: Adult; Aged; Aspartic Acid; Cataract; Female; Humans; Male; Middle Aged; Ophthalmic Solutions | 1966 |
Senile cataracts and aging changes in human proteins.
Topics: Aged; Aging; Aspartic Acid; Cataract; Crystallins; Humans; In Vitro Techniques; Molecular Weight; Pr | 1983 |
Hampered expression of isoaspartyl protein carboxyl methyltransferase gene in the human cataractous lens.
Topics: Aspartic Acid; Base Sequence; Blotting, Northern; Cataract; Epithelium; Gene Expression; Humans; Len | 1995 |
Determination of beta-isomerized aspartic acid as the corresponding alcohol.
Topics: Aluminum Compounds; Amino Acids; Asparagine; Aspartic Acid; Boranes; Cataract; Chymotrypsin; Crystal | 1994 |
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy)
Topics: Adolescent; Adult; Amino Acid Sequence; Aspartic Acid; Base Sequence; Cataract; Child; Child, Presch | 1993 |
Possible changes in secondary structure and composition of human lens capsules in hereditary congenital cataract.
Topics: Adult; Aspartic Acid; Cataract; Crystallins; Female; Fourier Analysis; Humans; Hydroxylysine; Lens C | 1996 |
Comparison of d-aspartic acid contents in alpha A-crystallin from normal and age-matched cataractous human lenses.
Topics: Amino Acid Sequence; Aspartic Acid; Case-Control Studies; Cataract; Chromatography, High Pressure Li | 2000 |
Mechanism of asparagine deamidation during human senile cataractogenesis.
Topics: Asparagine; Aspartic Acid; Cataract; Chromatography, High Pressure Liquid; Crystallins; Deamination; | 2001 |
Inversion and isomerization of Asp-58 residue in human alphaA-crystallin from normal aged lenses and cataractous lenses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Infant; Isomeri | 2001 |
[Clinical biochemical aspects of the prophylaxis and therapy of senile cataract with zinc aspartate (author's transl)].
Topics: Age Factors; Aged; Aspartic Acid; Cataract; Fructose-Bisphosphate Aldolase; Glucosephosphate Dehydro | 1978 |
Aspartic acid racemization in heavy molecular weight crystallins and water insoluble protein from normal human lenses and cataracts.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Cataract; Child; Child, Preschool; Crystallins; Human | 1978 |
Racemization in human lens: evidence of rapid insolubilization of specific polypeptides in cataract formation.
Topics: Age Factors; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens, Crystalline; Peptides; S | 1978 |
Aspartic acid racemisation in the human lens during ageing and in cataract formation.
Topics: Aging; Aspartic Acid; Cataract; Humans; Lens, Crystalline; Stereoisomerism | 1977 |
Contemporary possibilities of medicamentous prevention of cataract.
Topics: Adult; Aged; Aspartic Acid; Cataract; Drug Combinations; Female; Humans; Indazoles; Inosine Monophos | 1990 |
The sequences of two peptides from cataract lenses suggest they arise by deamidation.
Topics: Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cataract; Cattle; | 1990 |
Total hydrolysis of proteins with strongly reduced racemization of amino acids.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Carboxypeptidases; Cataract; Female; Humans; Hydrolysis; | 1990 |
Racemization of aspartyl residues in proteins from normal and cataractous human lenses: an aging process without involvement in cataract formation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens | 1989 |
D-amino acid in irradiated and aged mouse.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cataract; Crystallins; Male; Mice; Mice, Inbred Strains; | 1986 |
Lenticular and fundus changes induced by the intraocular infusion of sodium aspartate.
Topics: Animals; Aspartic Acid; Cataract; Fundus Oculi; Haplorhini; Injections; Intraocular Pressure; Lens, | 1974 |
Some characteristics of the p-chlorophenylalanine-induced cataract.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Cataract; Chromatography, Gas; Crystallins; Electroph | 1973 |
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cata | 1973 |
Protein metabolism in human senile cataract.
Topics: Adenosine Triphosphate; Aged; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Transport; C | 1971 |