aspartic acid has been researched along with Carcinoma in 22 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study is to evaluate the relationship between the aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) ratio and local disease control in patients with head and neck squamous cell carcinomas (HNSCC) treated with radiotherapy/chemoradiotherapy." | 8.02 | The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. ( Avilés-Jurado, FX; León, X; Pardo, L; Quer, M; Sansa, A; Terra, X; Valero, C; Venegas, MDP, 2021) |
| "Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA." | 7.66 | Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. ( Ardalan, B; Cooney, DA; Cysyk, RL; Han, N; Hankerson, JG; Harley, C; Jayaram, HN; Johnson, RK; Kensler, TW; Mutter, G; Reck, LJ, 1981) |
| "It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis." | 5.29 | Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994) |
| "The aim of this study is to evaluate the relationship between the aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) ratio and local disease control in patients with head and neck squamous cell carcinomas (HNSCC) treated with radiotherapy/chemoradiotherapy." | 4.02 | The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. ( Avilés-Jurado, FX; León, X; Pardo, L; Quer, M; Sansa, A; Terra, X; Valero, C; Venegas, MDP, 2021) |
| "Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA." | 3.66 | Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. ( Ardalan, B; Cooney, DA; Cysyk, RL; Han, N; Hankerson, JG; Harley, C; Jayaram, HN; Johnson, RK; Kensler, TW; Mutter, G; Reck, LJ, 1981) |
| "Many colorectal cancer (CRC) cells contain mutations in KRAS." | 1.43 | SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. ( Cai, Z; Chen, H; Cheng, KW; Go, MY; Jin, Y; Kang, W; Li, W; Li, X; Ng, SS; Qian, Y; Sung, JJ; To, KF; Tong, JH; Wong, CC; Wu, JL; Xu, J; Yu, J, 2016) |
| "It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis." | 1.29 | Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994) |
| "5-Fluorouracil (FUra) is a clinically useful antineoplastic agent." | 1.27 | Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983) |
| "One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen." | 1.26 | Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982) |
| "It was found that SV40-induced hamster tumors, BHK21/cl 13 cells in culture, certain carcinogen-induced tumors in the Ehrlich ascites tumor, and a number of human carcinomas and adenocarcinomas contained a distinct increase (3- to 20-fold) in the percentage of a late-eluting aspartyl-tRNA over that found in nonmalignant tissues, other animal tumors, and in human melanomas and sarcomas." | 1.25 | The distribution and properties of aspartyl transfer RNA in human and animal tumors. ( Bowen, JM; Briscoe, WT; Griffin, AC; McBride, C, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (54.55) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Sansa, A | 1 |
| Venegas, MDP | 1 |
| Valero, C | 1 |
| Pardo, L | 1 |
| Avilés-Jurado, FX | 1 |
| Terra, X | 1 |
| Quer, M | 1 |
| León, X | 1 |
| Bertero, T | 1 |
| Oldham, WM | 1 |
| Grasset, EM | 1 |
| Bourget, I | 1 |
| Boulter, E | 1 |
| Pisano, S | 1 |
| Hofman, P | 1 |
| Bellvert, F | 1 |
| Meneguzzi, G | 1 |
| Bulavin, DV | 1 |
| Estrach, S | 1 |
| Feral, CC | 1 |
| Chan, SY | 1 |
| Bozec, A | 1 |
| Gaggioli, C | 1 |
| Chen, WS | 1 |
| Li, JJ | 1 |
| Hong, L | 1 |
| Xing, ZB | 1 |
| Wang, F | 1 |
| Li, CQ | 1 |
| Wong, CC | 1 |
| Qian, Y | 1 |
| Li, X | 1 |
| Xu, J | 1 |
| Kang, W | 1 |
| Tong, JH | 1 |
| To, KF | 1 |
| Jin, Y | 1 |
| Li, W | 1 |
| Chen, H | 1 |
| Go, MY | 1 |
| Wu, JL | 1 |
| Cheng, KW | 1 |
| Ng, SS | 1 |
| Sung, JJ | 1 |
| Cai, Z | 1 |
| Yu, J | 1 |
| Zulhabri, O | 1 |
| Rahman, J | 1 |
| Ismail, S | 1 |
| Isa, MR | 1 |
| Wan Zurinah, WN | 1 |
| REITH, WS | 2 |
| CREASEY, WA | 1 |
| MARKIW, ME | 1 |
| Marcel, P | 1 |
| Lăcrămioara, BR | 1 |
| Valeriu, S | 1 |
| Krieger, MD | 1 |
| Panigrahy, A | 1 |
| McComb, JG | 1 |
| Nelson, MD | 1 |
| Liu, X | 1 |
| Gonzalez-Gomez, I | 1 |
| Gilles, F | 1 |
| Bluml, S | 1 |
| Presant, CA | 1 |
| Ardalan, B | 2 |
| Multhauf, P | 1 |
| Chan, C | 1 |
| Staples, R | 1 |
| Green, L | 1 |
| Browning, S | 1 |
| Carr, BI | 1 |
| Chang, FF | 1 |
| Thayer, W | 1 |
| Casper, ES | 1 |
| Vale, K | 1 |
| Williams, LJ | 1 |
| Martin, DS | 1 |
| Young, CW | 1 |
| Yang, LY | 1 |
| Drewinko, B | 1 |
| Weiss, GR | 1 |
| Ervin, TJ | 1 |
| Meshad, MW | 1 |
| Kufe, DW | 1 |
| Kensler, TW | 2 |
| Mutter, G | 1 |
| Hankerson, JG | 1 |
| Reck, LJ | 2 |
| Harley, C | 1 |
| Han, N | 1 |
| Cysyk, RL | 1 |
| Johnson, RK | 2 |
| Jayaram, HN | 1 |
| Cooney, DA | 2 |
| Sijens, PE | 1 |
| van Dijk, P | 1 |
| Oudkerk, M | 1 |
| Chong, VF | 1 |
| Rumpel, H | 1 |
| Fan, YF | 1 |
| Mukherji, SK | 1 |
| Amador, AG | 1 |
| Righi, PD | 1 |
| Radpour, S | 1 |
| Everett, ET | 1 |
| Weisberger, E | 1 |
| Langer, M | 1 |
| Eckert, GJ | 1 |
| Christen, AG | 1 |
| Campbell, S | 1 |
| Summerlin, DJ | 1 |
| Reynolds, N | 1 |
| Hartsfield, JK | 1 |
| Osieka, R | 1 |
| Houchens, DP | 1 |
| Goldin, A | 1 |
| Briscoe, WT | 1 |
| Griffin, AC | 1 |
| McBride, C | 1 |
| Bowen, JM | 1 |
| Daussin, F | 1 |
| Boschetti, E | 1 |
| Delmotte, F | 1 |
| Monsigny, M | 1 |
| Haskell, CM | 1 |
| Canellos, GP | 1 |
1 review available for aspartic acid and Carcinoma
| Article | Year |
|---|---|
Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
Topics: Aspartic Acid; Brain Diseases; Carcinoma; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy | 2016 |
21 other studies available for aspartic acid and Carcinoma
| Article | Year |
|---|---|
The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients.
Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; Biomarkers, Tumor; Carcin | 2021 |
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Breast Neoplasms; Cancer-Associated Fi | 2019 |
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.
Topics: Adenoma; Adult; Aged; Animals; Aspartic Acid; Biomarkers, Tumor; Carcinoma; Cell Line, Tumor; Cell M | 2016 |
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Topics: Adenine; Adenoma; Adult; Aged; Aged, 80 and over; Aspartic Acid; Carcinoma; Codon; Colorectal Neopla | 2012 |
Incorporation of radioactive aspartic acid into the proteins and related fractions in mice bearing the Ehrlich ascites carcinoma.
Topics: Animals; Ascites; Aspartic Acid; Carcinoma; Mice; Neoplasms; Proteins; Radioactivity | 1956 |
Incorporation of radioactive aspartic acid into the proteins and related fractions in mice bearing the Ehrlich ascites carcinoma.
Topics: Animals; Ascites; Aspartic Acid; Carcinoma; Mice; Neoplasms; Proteins; Radioactivity | 1956 |
Incorporation of radioactive aspartic acid into the proteins and related fractions in mice bearing the Ehrlich ascites carcinoma.
Topics: Animals; Ascites; Aspartic Acid; Carcinoma; Mice; Neoplasms; Proteins; Radioactivity | 1956 |
Incorporation of radioactive aspartic acid into the proteins and related fractions in mice bearing the Ehrlich ascites carcinoma.
Topics: Animals; Ascites; Aspartic Acid; Carcinoma; Mice; Neoplasms; Proteins; Radioactivity | 1956 |
BIOCHEMICAL EFFECTS OF THE VINCA ALKALOIDS--I. EFFECTS OF VINBLASTINE ON NUCLEIC ACID SYNTHESIS IN MOUSE TUMOR CELLS.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Me | 1964 |
Immobilization of alpha-[di-(beta-chloroethyl)-amide]-N-(m-nitrobenzoyl)-D,L-asparagic acid on xanthan.
Topics: Administration, Oral; Adsorption; Animals; Aspartic Acid; Carcinoma; Delayed-Action Preparations; Fe | 2003 |
Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Carcinoma; Cell Differentiation; Child; Child, Preschool; Choline; Choroi | 2005 |
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial.
Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptio | 1983 |
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin | 1983 |
A method to measure carcinoembryonic antigen neosynthesis by cultured colon carcinoma cells.
Topics: Acetylglucosamine; Aspartic Acid; Carcinoembryonic Antigen; Carcinoma; Cell Line; Chromatography, Af | 1980 |
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th | 1982 |
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
Topics: Amides; Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carcinoma; Cell Line; Dose-Response | 1981 |
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydr | 1981 |
Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Breast Neoplasms; Carcinoma; Choline; Contrast Media; Creatin | 1994 |
Temporal lobe changes following radiation therapy: imaging and proton MR spectroscopic findings.
Topics: Adult; Aspartic Acid; Carcinoma; Chlorine; Creatinine; Diagnosis, Differential; Female; Humans; Magn | 2001 |
Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Aspartic Acid; Carcinoma; Codon; Epoxide Hydrolases; Female | 2002 |
Chemotherapy of human colon cancer xenografts in athymic nude mice.
Topics: Acridines; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcinoma | 1977 |
The distribution and properties of aspartyl transfer RNA in human and animal tumors.
Topics: Adenocarcinoma; Animals; Aspartic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricet | 1975 |
p-Benzylthiocarbamoyl-aspartyl-daunorubicin-substituted polytrisacryl. A new drug acid-labile arm-carrier conjugate.
Topics: Acrylates; Aspartic Acid; Binding Sites; Carcinoma; Cell Survival; Daunorubicin; Hydrogen-Ion Concen | 1988 |
Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists.
Topics: Amino Acids; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Azaserine; Azo Compounds; Carcinoma; | 1970 |