Page last updated: 2024-08-17

aspartic acid and Cancer of Colon

aspartic acid has been researched along with Cancer of Colon in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (43.14)	18.7374
1990's	14 (27.45)	18.2507
2000's	6 (11.76)	29.6817
2010's	5 (9.80)	24.3611
2020's	4 (7.84)	2.80

Authors

Authors	Studies
Altinok, O; Bowne, WB; Orynbayeva, Z; Poggio, JL; Shieh, AC; Snyder, NW; Stein, DE	1
Deng, L; Ji, F; Jiang, P; Lan, X; Li, L; Xu, C; Yao, P; Zhao, S	1
Jia, Z; Li, A; Tian, Q; Wu, H; Xie, Y; Yang, Z; Zhang, H; Zhang, X; Zhang, Z	1
Choudhuri, R; Cook, JA; Gamson, J; Gohain, S; Leiker, AJ; Mathias, A; Mitchell, JB; Naz, S; Preston, O; Sowers, AL; Van Waes, C	1
Gao, S; Hu, J; Liang, Z; Wu, X	1
Boer, JM; Boot, A; Dihal, AA; Fariña-Sarasqueta, A; Fiocco, M; Kuppen, PJ; Morreau, H; Schrumpf, M; van Roon, EH; van Wezel, T; Zeestraten, EC	1
Alberts, SR; Berenberg, JL; Chan, E; Goldberg, RM; Gonsalves, WI; Grothey, A; Hubbard, JM; Limburg, PJ; Mahoney, MR; McWilliams, RR; Nair, S; Nelson, GD; Sargent, DJ; Sinicrope, FA; Thibodeau, SN	1
Alberts, SR; Berenberg, JL; Diasio, RB; Goldberg, RM; Lee, AM; Pavey, E; Sargent, DJ; Shi, Q; Sinicrope, FA	1
Barańczyk-Kuźma, A; Chrzanowska, A; Graboń, W; Joniec-Maciejak, I; Mielczarek-Puta, M; Otto-Ślusarczyk, D; Słabik, K	1
Galanko, J; Keku, T; Lawrence, LB; Martin, CF; Rohlfs, EM; Sandler, RS; Shaheen, NJ; Silverman, LM	1
Al-Fageeh, M; Dashwood, RH; Dashwood, WM; Li, Q; Myzak, MC	1
Hanaoka, K; Imai, Y; Kaneko, E; Kataoka, K; Kikuchi, K; Kumagai, M; Nagano, T; Nakamura, T; Sekino, M; Shimokado, K; Ueno, S; Yamasaki, Y	1
Chatterjee, N; Daugherty, SE; Fallin, MD; Hayes, RB; Huang, WY; Isaacs, WB; Platz, EA; Shugart, YY; Welch, R	1
Ardalan, B; Browning, S; Carr, BI; Chan, C; Chang, FF; Green, L; Multhauf, P; Presant, CA; Staples, R; Thayer, W	1
Bedikian, AY	1
Ardalan, B; Jamin, D; Jayaram, HN; Presant, CA	1
Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ	1
Hahn, RG; Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ	1
Gertz, MA; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ	1
Drewinko, B; Yang, LY	1
Chabner, BA; Donehower, RC; Erlichman, C; Klecker, R; Speyer, JL	1
Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR	1
Anderson, LW; Cysyk, RL; Erlichman, C; Karle, JM	1
Cao, S; Durrani, FA; Mayhew, EG; Peters, GJ; Rustum, YM; Van Laar, JA	1
Seitz, JF	1
Buyse, M; Le Bourgeois, JP; Lévy, E; Piedbois, P	1
Canney, PA; Cassidy, J; Jodrell, DI; Kaye, SB; Kerr, DJ; Oster, W; Steward, WP; Yosef, H	1
Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ	1
Kita, Y; Komi, N; Miyake, H; Nishi, M; Okada, A; Takehara, H; Yoshida, K	1
Bajaj, R; Hallam, S; Mao, X; Schwartz, EL; Wadler, S	1
Durrani, FA; Rustum, YM; van Laar, JA	1
Bakker, A; Finkelstein, SD; Sayegh, R; Swalsky, P	1
Christensen, S; Finkelstein, SD; Sayegh, R; Swalsky, PA	1
Cleaveland, ES; Cooney, DA; Ford, H; Kelley, JA; Paull, K; Zaharevitz, DW	1
Heinzlmann, M; Lang, SM; Loeschke, K; Stratakis, DF; Teschauer, W	1
Paranavitana, CM	1
Heath, TD; Kim, JS	1
Hamaguchi, T; Hrushesky, WJ; Kakizoe, T; Kataoka, K; Kawaguchi, T; Matsumura, Y; Mizumura, Y; Moriyasu, F; Nishiyama, N	1
Goldin, A; Houchens, DP; Johnson, RK; Osieka, R	1
Chabner, BA; Cohen, MH; Erlichman, C; Hubbard, SM; Levine, AS; McAvoy, LM; Strong, JM; Wiernik, PH	1
Kwong, LK; Tsuboi, KK	1
Edmunds, NH; Kwong, LK; Tsuboi, KK	1
Bruckner, HW; Motwani, BT	1
Buroker, TR; Cullinan, SA; Everson, LK; Fleming, TR; Klaassen, DJ; Krook, JE; Laurie, JA; Mailliard, JA; Marschke, RF; Moertel, CG	1
Bieri, A; Chiodetti, N; Floersheim, GL	1
Ardalan, B; Silberman, H; Singh, G	1
Camacho, FJ; Engstrom, PF; Green, MD; Greenwald, ES; Kaplan, BH; Muggia, FM; Wernz, JC	1
Chan, TC; Howell, SB; King, ME; Taetle, R; Young, B	1
Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M	1
Bedikian, A; Benvenuto, JA; Bodey, GP; Chiuten, DF; Freireich, EJ; Loo, TL; Miller, A; Valdivieso, M	1
Freeman, A; Holland, JF; Ohnuma, T; Sinks, LF	1

Reviews

4 review(s) available for aspartic acid and Cancer of Colon

Article	Year
Regional and systemic chemotherapy for advanced colorectal cancer. A review. Diseases of the colon and rectum, 1983, Volume: 26, Issue:5 Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms; Tegafur	1983
[Chemotherapy in cancers of the colon]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:2 Pt 3 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Interferons; Interleukin-2; Leucovorin; Phosphonoacetic Acid	1993
[Chemotherapy of metastasizing cancers of the colon and rectum]. Annales de chirurgie, 1993, Volume: 47, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Methotrexate; Neoplasm Metastasis; Phosphonoacetic Acid; Rectal Neoplasms	1993
Chemotherapy of advanced cancer of the colon and rectum. Seminars in oncology, 1991, Volume: 18, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms	1991

Trials

6 trial(s) available for aspartic acid and Cancer of Colon

Article	Year
DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147). Journal of the National Cancer Institute, 2014, Volume: 106, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Diarrhea; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genetic Predisposition to Disease; Humans; Leucovorin; Logistic Models; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Polymorphism, Single Nucleotide; Prospective Studies; Severity of Illness Index; Thrombocytopenia; Valine; Vomiting	2014
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:8 Topics: Adenoma; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies; Colonic Neoplasms; Female; Genetic Variation; Genotype; Glutamic Acid; Glycine; Haplotypes; Humans; Ibuprofen; Leucine; Lysine; Male; Methionine; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Racemases and Epimerases; Rectal Neoplasms; Serine; Valine	2007
Clinical trial of PALA and L-Alanosine in advanced colorectal carcinoma. Cancer treatment reports, 1983, Volume: 67, Issue:12 Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Nausea; Phosphonoacetic Acid; Rectal Neoplasms; Stomatitis	1983
A phase I-II study of N-(phosphonacetyl)-L-aspartic acid (PALA) added to 5-fluorouracil and folinic acid in advanced colorectal cancer. European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:7 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms	1994
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:12 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Levamisole; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Random Allocation; Rectal Neoplasms; Semustine; Streptozocin; Thymidine; Vincristine	1985
A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Organophosphorus Compounds; Pancreatic Neoplasms; Phosphonoacetic Acid; Random Allocation; Rectal Neoplasms	1988

Other Studies

41 other study(ies) available for aspartic acid and Cancer of Colon

Article	Year
Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. Journal of cellular physiology, 2020, Volume: 235, Issue:3 Topics: Aspartic Acid; Colonic Neoplasms; HCT116 Cells; Homeostasis; Humans; Lactic Acid; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Warburg Effect, Oncologic	2020
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature communications, 2020, 04-09, Volume: 11, Issue:1 Topics: AMP-Activated Protein Kinase Kinases; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Homeostasis; Humans; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Protein Serine-Threonine Kinases; RNA Interference; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2020
Integration of transcriptomics and metabolomics reveals anlotinib-induced cytotoxicity in colon cancer cells. Gene, 2021, Jun-20, Volume: 786 Topics: Aspartic Acid; Cell Cycle Proteins; Chondroitin Sulfate Proteoglycans; Chromatography, Liquid; Chromosomal Proteins, Non-Histone; Colonic Neoplasms; DNA Topoisomerases, Type II; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glutamine; Glycogen Phosphorylase; HCT116 Cells; Humans; Indoles; Metabolomics; Poly-ADP-Ribose Binding Proteins; Quinolines; Sequence Analysis, RNA; Tandem Mass Spectrometry	2021
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis. International journal of radiation oncology, biology, physics, 2021, 08-01, Volume: 110, Issue:5 Topics: Animals; Aspartic Acid; Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA Repair; Down-Regulation; G2 Phase Cell Cycle Checkpoints; Head and Neck Neoplasms; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Metabolomics; Mice; Mice, Nude; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Nucleotides; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays	2021
PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108 Topics: 6-Aminonicotinamide; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; beta Catenin; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Humans; Interleukin-6; Macrophages; MAP Kinase Signaling System; Methylthioinosine; STAT3 Transcription Factor; THP-1 Cells; Wnt Signaling Pathway	2018
The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors. PloS one, 2013, Volume: 8, Issue:11 Topics: Aged; Aspartic Acid; Cell Line, Tumor; Colonic Neoplasms; DNA Methylation; DNA Mutational Analysis; Exons; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Middle Aged; Mutation; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Valine	2013
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147. Journal of the National Cancer Institute, 2014, Volume: 106, Issue:7 Topics: Adult; Aged; Aspartic Acid; Clinical Trials, Phase III as Topic; Colonic Neoplasms; DNA Mismatch Repair; Female; Glutamic Acid; Glycine; Humans; Logistic Models; Male; Middle Aged; Molecular Epidemiology; Mutation; Neoplasm Grading; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Surveys and Questionnaires; Valine	2014
Lactate Formation in Primary and Metastatic Colon Cancer Cells at Hypoxia and Normoxia. Cell biochemistry and function, 2016, Volume: 34, Issue:7 Topics: Aspartate Aminotransferases; Aspartic Acid; Cell Count; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Culture Media; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lactic Acid; Models, Biological; Neoplasm Metastasis; Oxygen; RNA, Messenger; Serine	2016
Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. Journal of the National Cancer Institute, 2003, Jan-15, Volume: 95, Issue:2 Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies; Colonic Neoplasms; Cysteine; Feeding Behavior; Female; Hemochromatosis Protein; Heterozygote; Histidine; Histocompatibility Antigens Class I; Humans; Iron Compounds; Male; Meat; Membrane Proteins; Middle Aged; Mutation; North Carolina; Risk Assessment; Risk Factors; Tyrosine	2003
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene, 2004, Jun-17, Volume: 23, Issue:28 Topics: Amino Acid Substitution; Animals; Aspartic Acid; beta Catenin; Binding Sites; Colonic Neoplasms; Cytoskeletal Proteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Phosphorylation; Rats; Serine; Trans-Activators; Ubiquitin	2004
Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging. Colloids and surfaces. B, Biointerfaces, 2007, Apr-15, Volume: 56, Issue:1-2 Topics: Animals; Aspartic Acid; Coated Materials, Biocompatible; Colonic Neoplasms; Contrast Media; Female; Hydrogen-Ion Concentration; Hydroxides; Iron; Magnetic Resonance Imaging; Mice; Mice, Inbred Strains; Nanoparticles; Neoplasm Transplantation; Neoplasms; Particle Size; Polyethylene Glycols; Polymers; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2007
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial. Medical and pediatric oncology, 1983, Volume: 11, Issue:3 Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptions; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Rectal Neoplasms; Sarcoma	1983
Phase I study of continuous-infusion PALA and 5-FU. Cancer treatment reports, 1984, Volume: 68, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Drug Eruptions; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid	1984
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasms; Confusion; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine	1984
A phase II study of the combination, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and N-(phosphonacetyl)-L-aspartate (PALA), in patients with advanced large bowel cancer. American journal of clinical oncology, 1984, Volume: 7, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carmustine; Colonic Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Rectal Neoplasms	1984
A method to measure carcinoembryonic antigen neosynthesis by cultured colon carcinoma cells. Journal of the National Cancer Institute, 1980, Volume: 65, Issue:2 Topics: Acetylglucosamine; Aspartic Acid; Carcinoembryonic Antigen; Carcinoma; Cell Line; Chromatography, Affinity; Colonic Neoplasms; Fucose; Humans; Radioimmunoassay	1980
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection. Journal of the National Cancer Institute, 1982, Volume: 68, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Melanoma; Middle Aged; Neoplasms; Organophosphorus Compounds; Ovarian Neoplasms; Pancreatic Neoplasms; Phosphonoacetic Acid; Sarcoma	1982
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. Cancer treatment reports, 1982, Volume: 66, Issue:2 Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Infusions, Parenteral; Injections, Intravenous; Middle Aged; Organophosphorus Compounds; Pancreatic Neoplasms; Phosphonoacetic Acid; Sarcoma	1982
Serum uridine levels in patients receiving N-(phosphonacetyl)-L-aspartate. Cancer research, 1980, Volume: 40, Issue:8 Pt 1 Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Humans; Melanoma; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine	1980
Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-L-aspartate in murine colon carcinoma no. 26. European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Female; Floxuridine; Mice; Mice, Inbred BALB C; Phosphonoacetic Acid; Tumor Cells, Cultured	1995
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. Cancer research, 1994, Aug-15, Volume: 54, Issue:16 Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured	1994
Increased aspartate and glutamate levels in both gastric and colon cancer tissues. The Tokushima journal of experimental medicine, 1993, Volume: 40, Issue:1-2 Topics: Aspartic Acid; Colonic Neoplasms; Gastric Mucosa; Glutamates; Glutamic Acid; Humans; Intestinal Mucosa; Protein Binding; Stomach Neoplasms	1993
N-(phosphonacetyl)-L-aspartate synergistically enhances the cytotoxicity of 5-fluorouracil/interferon-alpha-2a against human colon cancer cell lines. Molecular pharmacology, 1993, Volume: 44, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Base Sequence; Cell Division; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Molecular Sequence Data; Nucleotides; Oligodeoxyribonucleotides; Phosphonoacetic Acid; Recombinant Proteins; RNA, Neoplasm; Tumor Cells, Cultured	1993
Antitumor activity of the weekly intravenous push schedule of 5-fluoro-2'-deoxyuridine +/- N-phosphonacetyl-L-aspartate in mice bearing advanced colon carcinoma 26. Cancer research, 1993, Apr-01, Volume: 53, Issue:7 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Cytidine Triphosphate; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Infusions, Intravenous; Leukemia L1210; Mice; Mice, Inbred BALB C; Phosphonoacetic Acid; Uridine Triphosphate	1993
Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis. Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:5 Topics: Adenocarcinoma; Aspartic Acid; Biomarkers, Tumor; Codon; Colonic Neoplasms; DNA, Neoplasm; Exons; Follow-Up Studies; Genes, ras; Glutamine; Histidine; Humans; Mutation; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Rectal Neoplasms; Retrospective Studies; Survival Rate; Valine	1993
Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. Cancer, 1993, Jun-15, Volume: 71, Issue:12 Topics: Adenine; Adenocarcinoma; Aspartic Acid; Biology; Codon; Colonic Neoplasms; Gene Frequency; Genes, ras; Genotype; Guanine; Humans; Liver Neoplasms; Lymphatic Metastasis; Mutation; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Rectal Neoplasms	1993
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar. Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3 Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lung Neoplasms; Male; Melanoma; Mitochondria; Orotic Acid; Ovarian Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Prostatic Neoplasms; Ribonucleotides; Sodium Bicarbonate; Software; Tumor Cells, Cultured	1996
Detection of Ki-ras mutations by PCR and differential hybridization and of p53 mutations by SSCP analysis in endoscopically obtained lavage solution from patients with long-standing ulcerative colitis. The American journal of gastroenterology, 1997, Volume: 92, Issue:12 Topics: Aspartic Acid; Biopsy; Case-Control Studies; Cell Transformation, Neoplastic; Codon; Colitis, Ulcerative; Colonic Neoplasms; Colonoscopy; Digoxigenin; DNA; Exons; Female; Genes, p53; Genes, ras; Genetic Testing; Glycine; Humans; Immunoblotting; Male; Mutation; Nucleic Acid Hybridization; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Therapeutic Irrigation; Valine	1997
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization. Molecular and cellular probes, 1998, Volume: 12, Issue:5 Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Breast Neoplasms; Codon; Colonic Neoplasms; DNA Mutational Analysis; DNA Primers; Female; Genes, ras; Glycine; Heterozygote; Humans; Lung Neoplasms; Nucleic Acid Hybridization; Oligonucleotide Probes; Point Mutation; Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Cells, Cultured	1998
In vitro cytotoxic effect of N-(phosphonacetyl)-L-aspartic acid in liposome against C-26 murine colon carcinoma. Archives of pharmacal research, 2000, Volume: 23, Issue:2 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Carriers; Liposomes; Mice; Particle Size; Phosphonoacetic Acid; Tumor Cells, Cultured	2000
Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:3 Topics: Animals; Aspartic Acid; Breast Neoplasms; Cell Survival; Cisplatin; Colonic Neoplasms; Drug Carriers; Female; Humans; Kidney; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Micelles; Polyethylene Glycols; Stomach Neoplasms; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Chemotherapy of human colon cancer xenografts in athymic nude mice. Cancer, 1977, Volume: 40, Issue:5 Suppl Topics: Acridines; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcinoma; Cell Line; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Lomustine; Male; Maytansine; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Streptozocin; Transplantation, Heterologous; Triazines	1977
Phase I trial of N-(phosphonacetyl)-L-aspartate. Cancer research, 1979, Volume: 39, Issue:10 Topics: Adolescent; Adult; Aged; Aspartic Acid; Colonic Neoplasms; Diarrhea; Drug Eruptions; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Remission, Spontaneous; Stomatitis	1979
Antiproliferative agents and differential survival between normal and cancer cells. Cancer research, 1978, Volume: 38, Issue:11 Pt 1 Topics: Adenocarcinoma; Aspartic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Thymidine	1978
Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells. Cancer research, 1977, Volume: 37, Issue:9 Topics: Animals; Aspartic Acid; Cell Division; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Humans; Kinetics; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidines; Transplantation, Isogeneic; Uridine	1977
Differential radioprotection of bone marrow and tumour cells by zinc aspartate. The British journal of radiology, 1988, Volume: 61, Issue:726 Topics: Adenocarcinoma; Animals; Aspartic Acid; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Colonic Neoplasms; Female; Gamma Rays; Humans; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Radiation-Protective Agents; Sarcoma, Ewing	1988
Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer. Cancer treatment reports, 1987, Volume: 71, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Pilot Projects; Rectal Neoplasms	1987
Modulation of the activity of PALA by dipyridamole. Cancer treatment reports, 1985, Volume: 69, Issue:4 Topics: Animals; Aspartic Acid; Biological Transport; Cell Line; Colonic Neoplasms; Dipyridamole; Drug Interactions; Humans; In Vitro Techniques; Lethal Dose 50; Leukemia, Myeloid; Melanoma; Mice; Mice, Nude; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidine Nucleosides; Tritium; Uridine	1985
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination. Cancer treatment reports, 1985, Volume: 69, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine	1985
Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study. American journal of clinical oncology, 1985, Volume: 8, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinoma, Bronchogenic; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Half-Life; Humans; Infusions, Parenteral; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine	1985
Biochemical and pharmacological studies with asparaginase in man. Cancer research, 1970, Volume: 30, Issue:9 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colonic Neoplasms; Escherichia coli; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Melanoma; Metabolic Clearance Rate; Middle Aged; Multiple Myeloma; Neoplasms; Neuroblastoma; Osteosarcoma	1970