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aspartic acid and Brain Neoplasms

aspartic acid has been researched along with Brain Neoplasms in 312 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

ExcerptRelevanceReference
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."9.13Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."9.12[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."7.77Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."7.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)."7.72Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."5.40Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis."5.29Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994)
"Thirteen patients with recurrent glioblastoma were enrolled in RTOG 0625/ACRIN 6677, a prospective multicenter trial in which bevacizumab was used in combination with either temozolomide or irinotecan."5.17Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. ( Barboriak, DP; Bokstein, F; Boxerman, JL; Gilbert, MR; McKinstry, RC; Ratai, EM; Safriel, Y; Snyder, BS; Sorensen, AG; Zhang, Z, 2013)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."5.13Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."5.12[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
" There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids."4.89Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013)
" This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors."4.85Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009)
" These methods were evaluated for segmentation of volumetric MRSI studies of gliomas using maps of the choline to N-acetylaspartate ratio, and a qualitative comparison of lesion volumes carried out."3.91Lesion segmentation for MR spectroscopic imaging using the convolution difference method. ( Maudsley, AA, 2019)
"Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)."3.85Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017)
"Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy."3.803-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014)
"Peritumoral N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, Cho/NAA and rCBV significantly differentiated glioblastomas from intracranial metastases."3.78Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. ( Fezoulidis, I; Fountas, K; Kapsalaki, E; Kousi, E; Svolos, P; Theodorou, K; Tsougos, I, 2012)
"There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas."3.78Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. ( Shang, HB; Zhang, WF; Zhao, WG, 2012)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."3.77Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
" The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) grade II-III gliomas."3.77Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. ( Blasel, S; Hattingen, E; Jansen, V; Mueller, K; Pfeilschifter, W; Zanella, F, 2011)
"Metabolite maps of N-acetyl aspartate, choline and creatine were generated using (1)H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy."3.76Grid-free interactive and automated data processing for MR chemical shift imaging data. ( Confort-Gouny, S; Cozzone, PJ; Guye, M; Kober, F; Le Fur, Y; Nicoli, F, 2010)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."3.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined."3.73Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006)
"The ratios of choline (Cho) to N-acetylaspartate (NAA) and Cho to creatine (Cr) in those with high-grade astrocytomas (n=4) were significantly higher than in those with low-grade astrocytomas (n=17) (t=2."3.73In vivo research in astrocytoma cell proliferation with 1H-magnetic resonance spectroscopy: correlation with histopathology and immunohistochemistry. ( Chen, J; Chen, XL; Huang, SL; Li, T, 2006)
"In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)."3.73In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005)
"To evaluate an intracranial polymer implant containing bromodeoxyuridine (BrdUrd) and N-(phosphonacetyl)-L-aspartic acid (PALA) in combination with external beam radiotherapy (EBRT) in the treatment of a rat glioma."3.72Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. ( Lehnert, S; Li, Y; Owusu, A, 2004)
"To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)."3.72Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."3.72In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."3.72In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
"Data obtained preoperatively from three-dimensional (3D)/proton magnetic resonance (MR) spectroscopy were compared with the results of histopathological assays of tissue biopsies obtained during surgery to verify the sensitivity and specificity of a choline-containing compound-N-acetylaspartate index (CNI) used to distinguish tumor from nontumorous tissue within T2-hyperintense and contrast-enhancing lesions of patients with untreated gliomas."3.71Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. ( Berger, MS; Dillon, WP; Graves, EE; Lu, Y; McDermott, MW; McKnight, TR; Nelson, SJ; Pirzkall, A; Vigneron, DB; von dem Bussche, MH, 2002)
" MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis."3.71[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002)
" Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA."3.71Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. ( Herminghaus, S; Krings, T; Lanfermann, H; Marquardt, G; Möller-Hartmann, W; Pilatus, U; Zanella, FE, 2002)
"Seven patients responded to tamoxifen therapy (three with glioblastomas multiforme; four with anaplastic astrocytomas), and nine did not (six with glioblastomas multiforme; three with anaplastic astrocytomas)."3.70Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy. ( Arnold, DL; Caramanos, Z; Langleben, A; LeBlanc, R; Preul, MC; Shenouda, G; Villemure, JG, 2000)
" We compared the LR sensitivity, specificity, and receiver operator characteristic (ROC) curve area (Az) with the sensitivity and specificity of blinded and unblinded qualitative MRS interpretations and a choline (Cho)/N-acetylaspartate (NAA) amplitude ratio criterion."3.70Discrimination between neoplastic and nonneoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model. ( Bowen, W; Butzen, J; Chetty, V; Donahue, K; Haughton, V; Kim, T; Krouwer, H; Li, SJ; Mark, L; Meyer, G; Mueller, W; Neppl, R; Prost, R; Rand, S, 2000)
"(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas."3.69Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995)
" All high-grade gliomas (n = 37) showed high choline and low or absent N-acetyl-L-aspartate and creatine along with lipid and/or lactate, whereas low-grade gliomas (n = 23) were characterized by low N-acetyl-aspartate and creatine and high choline and presence of only lactate."3.69Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995)
" The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4."3.69Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. ( Bandou, K; Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1995)
" We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic ("nu/nu") mice."3.69Effects of therapy on the 1H NMR spectrum of a human glioma line. ( Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD, 1994)
"Postradiation treatment necrosis is one of the most serious late sequelae and appears within 6 months."3.01Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis. ( Aseel, A; McCarthy, P; Mohammed, A, 2023)
"Linear regression analyses between seizure duration and NAA/Cr decrease was not significant."2.69Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy. ( Andermann, F; Arnold, DL; Cendes, F; Dubeau, F; Li, LM; Miller, SP; Tasch, E, 2000)
"necrosis in patients with primary brain tumors or brain metastasis."2.53Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis. ( Chen, YC; Chuang, MT; Liu, YS; Tsai, YS; Wang, CK, 2016)
"The choline/NAA ratio was 3."2.40Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. ( Ball, WS; Ballard, E; Dunn, RS; Egnaczyk, GF; Holland, SK; Hwang, JH, 1998)
"Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood."1.62Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas. ( Abe, M; Hirose, Y; Inamasu, J; Kumon, M; Kuwahara, K; Murayama, K; Nakae, S; Ohba, S; Sasaki, H; Yamada, S, 2021)
"Introduction: Brain tumors if timely diagnosed are sure to be treated through shorter processes."1.48The Role of Single Voxel MR Spectroscopy, T2 Relaxation Time and Apparent Diffusion Coefficient in Determining the Cellularity of Brain Tumors by MATLAB Software ( Abdolmohammadi, J; Amiri, J; Arefan, D; Faeghi, F; Haghighatkhah, H; Zali, A, 2018)
"Thirty-five patients with brain metastases underwent baseline single slice multi-voxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20)."1.46Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. ( Bulik, M; Burkon, P; Dobiaskova, M; Hynkova, L; Jancalek, R; Kazda, T; Laack, NN; Pospisil, P; Slampa, P, 2017)
"Glioma is the most common type of the primary CNS tumor."1.43Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. ( Cui, Y; Li, FY; Li, HX; Shi, WQ; Wang, JZ; Xu, YJ; Zeng, QS, 2016)
"Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence - median time to progression was 6."1.43Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. ( Bulik, M; Jancalek, R; Kazda, T; Lakomy, R; Pospisil, P; Slampa, P; Smrcka, M, 2016)
"Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily."1.42Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. ( Bulik, M; Burkon, P; Dobiaskova, M; Hynkova, L; Jancalek, R; Kazda, T; Pospisil, P; Slampa, P, 2015)
"Neurocytomas are tumors or neuronal differentiation, typically located within the supratentorial ventricular system."1.40Primary central neurocytoma of the mesencephalic tectum in a pediatric patient. ( Gordillo, C; Jimenez, JA; Manzanares, R; Navas, M; Shakur, SF; Sola, RG; Torres, CV, 2014)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."1.40Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy."1.38Magnetic resonance imaging of solitary brain metastases: main findings of nonmorphological sequences. ( Colosimo, C; De Waure, C; Di Lella, GM; Gaudino, S; Gualano, MR; Lo Russo, VS; Piludu, F; Quaglio, FR; Russo, R, 2012)
"The histological diagnosis was anaplastic oligodendroglioma (WHO grade III)."1.37[Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]. ( Akutsu, H; Anno, I; Isobe, T; Masumoto, T; Matsumura, A; Nakai, K; Shiigai, M; Takano, S; Yamamoto, T, 2011)
"Segmental neurofibromatosis 1 (segmental NF-1) is a rare genodermatosis caused by somatic mutations in the NF-1 gene."1.36A clinical and magnetic resonance spectroscopy study of a brain tumor in a patient with segmental neurofibromatosis. ( Ben Yahia, S; Boughammoura-Bouatay, A; Chebel, S; Frih-Ayed, M; Golli, M; Khairallah, M; Salem, R, 2010)
"We report 12 cases of Gliomatosis cerebri (GC), a rare brain neoplasm, to define its semeiologic criteria."1.36Gliomatosis cerebri, imaging findings of 12 cases. ( Cosnard, G; de Coene, B; Desclée, P; Godfraind, C; Hernalsteen, D; Rommel, D, 2010)
"Gliosarcoma is an uncommon variant of glioblastoma multiforme, which is composed of gliomatous and sarcomatous elements."1.35Giant infantile gliosarcoma: magnetic resonance imaging findings. ( Bulakbasi, N; Chen, L; Kocaoglu, M; Onguru, O; Sanal, HT, 2008)
"Eleven patients with primary brain tumors undergoing cranial radiation therapy (RT) were included."1.35Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study. ( Cao, Y; Chenevert, TL; Elias, A; Gomez Hassan, DM; Junck, L; Lawrence, TS; McKeever, P; Nagesh, V; Rogers, L; Sundgren, PC; Tsien, C, 2009)
"Desmoplastic infantile gangliogliomas (DIG) are rare benign intracranial neoplasms of early childhood with involvement of superficial cerebral cortex and leptomeninges."1.35Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. ( Balaji, R; Ramachandran, K, 2009)
"Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury."1.34Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007)
"Gliomatosis cerebri is a rare brain tumor with a short survival time; for this reason, it is difficult to establish the degree of aggressivity in vivo."1.341H MR spectroscopy in the assessment of gliomatosis cerebri. ( Benito, C; Desco, M; García-Barreno, P; Guzmán-de-Villoria, JA; Muñoz, L; Reig, S; Sánchez-González, J, 2007)
"We present a gliomatosis cerebri case in which we made the radiological diagnosis using the MR spectroscopy findings; the diagnosis was confirmed by subsequent biopsy and histopathologic evaluation."1.33Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri. ( Basak, M; Can, M; Erturk, M; Karatag, O; Tanik, C; Uysal, E; Yildirim, H, 2005)
"Six patients with brain metastases, 13 healthy volunteers, and a phantom containing brain metabolites were examined using two clinical MR instruments operating at 1."1.33Clinical 1H magnetic resonance spectroscopy of brain metastases at 1.5T and 3T. ( Gribbestad, IS; Kristoffersen, A; Lundgren, S; Singstad, T; Sjøbakk, TE; Sonnewald, U; Svarliaunet, AJ, 2006)
"One hundred and four metastatic brain tumors were evaluated by long-echo (TR, 2000 ms; TE, 136 ms) single-voxel volume-selected proton MRS."1.33Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile. ( Chernov, MF; Hayashi, M; Hori, T; Izawa, M; Ono, Y, 2006)
"Ten patients with untreated gliomas were examined on a 1."1.32Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. ( Buslei, R; Fahlbusch, R; Ganslandt, O; Gruber, S; Moser, E; Nimsky, C; Stadlbauer, A, 2004)
"Combined treatment of primary brain tumors (surgery + postoperative radiotherapy) causes alteration of brain metabolism, even in regions of the brain far from the postoperative tumor bed and receiving relatively low total doses of radiation."1.321H-MR spectroscopy of normal brain tissue before and after postoperative radiotherapy because of primary brain tumors. ( Maciejewski, B; Rutkowski, T; Sokol, M; Tarnawski, R, 2003)
"The diagnosis and therapy of childhood brain tumors, most of which are low grade, can be complicated because of their frequent adjacent location to crucial structures, which limits diagnostic biopsy."1.32Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. ( Anthony, DC; Astrakas, LG; Black, PM; De Girolami, U; Tarbell, NJ; Tzika, AA; Zarifi, MK; Zurakowski, D, 2004)
"Eighty-five brain metastases in 81 patients were investigated before treatment and 16-18h thereafter."1.32Early metabolic changes in metastatic brain tumors after Gamma Knife radiosurgery: 1H-MRS study. ( Abe, K; Chernov, MF; Hayashi, M; Hori, T; Izawa, M; Kubo, O; Ono, Y; Usukura, M, 2004)
"The differential diagnosis between brain abscesses and necrotic tumors such as glioblastomas is sometimes difficult to establish by conventional computed tomography and magnetic resonance imaging."1.31Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports. ( Harada, M; Kageji, T; Nagahiro, S; Nakaiso, M; Takimoto, O; Uno, M, 2002)
"Choline peak area was increased in tumor, creatine and N-acetyl aspartate were decreased in edema and tumor compared with unaffected brain tissue."1.311H chemical shift imaging characterization of human brain tumor and edema. ( Oudkerk, M; Sijens, PE, 2002)
"High-grade brain tumors are known to have a high rate of glucose (Glc) consumption."1.31High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001)
"The diagnosis of gliomatosis cerebri with MR imaging is known to be difficult."1.31MR spectroscopy in gliomatosis cerebri. ( Bendszus, M; Burger, R; Klein, R; Schichor, C; Solymosi, L; Tonn, JC; Warmuth-Metz, M, 2000)
"Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells."1.31Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000)
"We examined 120 patients with brain tumors using a 1."1.31In vivo proton magnetic resonance spectroscopy of brain tumors. ( Fountas, KN; Gotsis, SD; Johnston, KW; Kapsalaki, EZ; Kapsalakis, JZ; Papadakis, N; Robinson, JS; Smisson , HF, 2000)
"The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods."1.31Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001)
"First, it allows to distinguish brain tumors from abscesses."1.31[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis]. ( Berry, I; Ibarrola, D; Malet-Martino, M; Sabatier, J, 2001)
"Children who have brain tumors are at risk for a variety of treatment-related sequelae, including neuropsychological and cognitive impairment, neurologic deficits, and neuroendocrinologic disturbances."1.30Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site. ( Davis, PC; Morris, R; Padgett, CA; Shapiro, MB; Waldrop, SM, 1998)
"Seventeen brain tumors were measured by 1H-CSI (chemical shift imaging) in a 1."1.30Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. ( Furuya, S; Ide, M; Kizu, O; Maeda, T; Morishita, H; Naruse, S; Ueda, S, 1997)
"Fifteen patients with brain tumors and 10 healthy children underwent MR imaging and MR spectroscopy on a 1."1.30Multivoxel proton MR spectroscopy and hemodynamic MR imaging of childhood brain tumors: preliminary observations. ( Barnes, PD; Tzika, AA; Vajapeyam, S, 1997)
"Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas."1.29Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993)
"We encountered a case of brain abscess that was difficult to differentiate from glioblastoma."1.29Brain abscess observed by localized proton magnetic resonance spectroscopy. ( Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1994)
"Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values."1.29Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996)
"It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis."1.29Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994)
"Thirteen cases of brain cancer treated by radiation therapy were examined by 1H magnetic resonance spectroscopy and gadolinium-enhanced T1-weighted magnetic resonance imaging and reexamined at 2-month intervals."1.29Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human brain cancer. Unexpected inverse correlation between the changes in tumor choline level and post-gadolinium magnetic resonance imaging contrast. ( Levendag, PC; Oudkerk, M; Sijens, PE; van Dijk, P; Vecht, CJ, 1995)
"Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy."1.29Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. ( Calabrese, G; Falini, A; Lipari, S; Losa, M; Origgi, D; Scotti, G; Triulzi, F, 1996)
"Total creatine was decreased in all brain tumors in comparison with normal brain tissues, but was relatively higher in neuroectodermal tumors than in other brain tumors."1.29Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. ( Kajiwara, H; Kinoshita, Y; Koga, Y; Yokota, A, 1994)
"Meningiomas were further characterized by the presence of alanine."1.29Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumours. ( Blackband, SJ; Horsman, A; Lowry, M; Manton, DJ, 1995)
"External radiation therapy for brain tumors exposes healthy areas of brain to considerable doses of radiation."1.29Radiation-induced changes in human brain metabolites as studied by 1H nuclear magnetic resonance spectroscopy in vivo. ( Johansson, R; Kauppinen, R; Soimakallio, S; Tenhunen, M; Usenius, JP; Usenius, T; Vainio, P, 1995)
"Choline values were lower in chronic radiation necrosis than in solid anaplastic tumors (P < ."1.28Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance. ( Alger, JR; Bizzi, A; Di Chiro, G; Dietz, MJ; Dwyer, AJ; Frank, JA; Fulham, MJ; Raman, R; Shih, HH; Sobering, GS, 1992)
"This report examines the safety issues related to the nutritive sweetener aspartame, including possible toxic effects of aspartame's component amino acids, aspartic acid and phenylalanine, and its major decomposition products, methanol and diketopiperazine, and the potential synergistic effect of aspartame and dietary carbohydrate on brain neurochemicals."1.27Aspartame. Review of safety issues. Council on Scientific Affairs. ( , 1985)
"In 58 patients with brain tumors of a different histological structure the authors examined the amino acid content in the CSF (in 30 cases ventricular and in 28--lumbar fluid)."1.26[Amino acid composition of ventricular and lumbar cerebrospinal fluid in brain tumors]. ( Krivopusk, ME, 1977)

Research

Studies (312)

TimeframeStudies, this research(%)All Research%
pre-199011 (3.53)18.7374
1990's68 (21.79)18.2507
2000's116 (37.18)29.6817
2010's103 (33.01)24.3611
2020's14 (4.49)2.80

Authors

AuthorsStudies
Rudnay, M1
Waczulikova, I1
Bullova, A1
Rjaskova, G1
Chorvath, M1
Jezberova, M1
Lehotska, V1
Mekala, JR1
Kurappalli, RK1
Ramalingam, P1
Moparthi, NR1
Farche, MK1
Fachinetti, NO1
da Silva, LR1
Matos, LA1
Appenzeller, S1
Cendes, F2
Reis, F1
Tran, D3
Nguyen, DH3
Nguyen, HK3
Nguyen-Thanh, VA3
Dong-Van, H3
Nguyen, MD3
De Stefano, FA1
Morell, AA1
Smith, G1
Warner, T1
Soldozy, S1
Elarjani, T1
Eichberg, DG1
Luther, E1
Komotar, RJ1
Aseel, A1
McCarthy, P1
Mohammed, A1
Tensaouti, F1
Desmoulin, F1
Gilhodes, J1
Roques, M1
Ken, S2
Lotterie, JA1
Noël, G1
Truc, G1
Sunyach, MP1
Charissoux, M1
Magné, N1
Lubrano, V2
Péran, P1
Cohen-Jonathan Moyal, E2
Laprie, A3
Vidya Shankar, R1
Hu, HH1
Bikkamane Jayadev, N1
Chang, JC1
Kodibagkar, VD2
Zeinali-Rafsanjani, B1
Mosleh-Shirazi, MA1
Faghihi, R1
Saeedi-Moghadam, M1
Lotfi, M1
Jalli, R1
Goryawala, M1
Saraf-Lavi, E1
Nagornaya, N1
Heros, D1
Komotar, R1
Maudsley, AA5
Boban, J1
Thurnher, MM1
Brkic, S1
Lendak, D1
Bugarski Ignjatovic, V1
Todorovic, A1
Kozic, D2
Wang, AP1
Suryavanshi, T1
Marcucci, M1
Fong, C1
Whitton, AC1
Reddy, KKV1
Flores-Alvarez, E1
Anselmo Rios Piedra, E1
Cruz-Priego, GA1
Durand-Muñoz, C1
Moreno-Jimenez, S2
Roldan-Valadez, E2
Zhao, JP1
Cui, CX1
Wang, JC1
Su, HW1
Duan, CF1
Liu, XJ1
Mishkovsky, M1
Gusyatiner, O1
Lanz, B2
Cudalbu, C2
Vassallo, I2
Hamou, MF2
Bloch, J1
Comment, A1
Gruetter, R2
Hegi, ME2
Nakae, S1
Kumon, M1
Murayama, K1
Ohba, S1
Sasaki, H1
Inamasu, J1
Kuwahara, K1
Yamada, S1
Abe, M1
Hirose, Y1
Alirezaei, Z1
Amouheidari, A1
Hassanpour, M1
Davanian, F1
Iraji, S1
Shokrani, P1
Nazem-Zadeh, MR1
Ditter, P1
Hattingen, E2
Gruber, S5
Heckova, E1
Strasser, B1
Považan, M1
Hangel, GJ1
Minarikova, L1
Trattnig, S1
Bogner, W1
Liu, Z1
Zhang, J4
Qiao, L1
Sun, T1
Zheng, X1
Zheng, M1
Xie, Z1
Lai, M1
Poitry-Yamate, C1
Gao, W1
Wang, X1
Li, F2
Shi, W1
Li, H1
Zeng, Q2
Carlin, D1
Babourina-Brooks, B1
Davies, NP1
Wilson, M1
Peet, AC2
Chen, BB1
Lu, YS1
Yu, CW1
Lin, CH1
Chen, TW1
Wei, SY1
Cheng, AL1
Shih, TT1
Pedrosa de Barros, N1
Meier, R1
Pletscher, M1
Stettler, S1
Knecht, U1
Herrmann, E1
Schucht, P1
Reyes, M1
Gralla, J1
Wiest, R1
Slotboom, J1
Abdolmohammadi, J1
Faeghi, F1
Arefan, D1
Zali, A1
Haghighatkhah, H1
Amiri, J1
Gurbani, SS2
Sheriff, S1
Shim, H2
Cooper, LAD1
Choi, C4
Ganji, S1
Hulsey, K1
Madan, A2
Kovacs, Z2
Dimitrov, I1
Zhang, S1
Pichumani, K1
Mendelsohn, D1
Mickey, B1
Malloy, C1
Bachoo, R1
Deberardinis, R1
Maher, E1
Ratai, EM2
Zhang, Z1
Snyder, BS1
Boxerman, JL1
Safriel, Y1
McKinstry, RC1
Bokstein, F2
Gilbert, MR1
Sorensen, AG1
Barboriak, DP1
Lu, SS1
Kim, SJ1
Kim, HS1
Choi, CG1
Lim, YM1
Kim, EJ1
Kim, DY1
Cho, SH1
Navas, M1
Sola, RG1
Torres, CV1
Shakur, SF1
Manzanares, R1
Gordillo, C1
Jimenez, JA1
Balos, DR1
Gavrilović, S1
Lavrnić, S1
Vasić, B1
Macvanski, M1
Damjanović, D1
Opinćal, TS1
Tsen, AR1
Long, PM1
Driscoll, HE1
Davies, MT1
Teasdale, BA1
Penar, PL1
Pendlebury, WW1
Spees, JL1
Lawler, SE1
Viapiano, MS1
Jaworski, DM1
Roder, C1
Skardelly, M1
Ramina, KF1
Beschorner, R1
Honneger, J1
Nägele, T1
Tatagiba, MS1
Ernemann, U1
Bisdas, S2
Mama, N1
Ben Abdallah, A1
Hasni, I1
Kadri, K1
Arifa, N1
Ladib, M1
Tlili-Graiess, K1
Muruganandham, M1
Clerkin, PP1
Smith, BJ1
Anderson, CM1
Morris, A1
Capizzano, AA1
Magnotta, V1
McGuire, SM1
Smith, MC1
Bayouth, JE1
Buatti, JM1
Raschke, F1
Jones, TL1
Barrick, TR1
Howe, FA3
Ganji, SK3
An, Z1
Choe, KS1
Pinho, MC1
Bachoo, RM2
Maher, EM1
Parra, NA1
Gupta, RK2
Ishkanian, F1
Huang, K1
Walker, GR1
Padgett, K1
Roy, B1
Panoff, J1
Markoe, A1
Stoyanova, R1
Saito, K1
Toda, M1
Yoshida, K1
Deviers, A1
Filleron, T1
Rowland, B1
Laruelo, A1
Catalaa, I3
Celsis, P1
Berry, I3
Mogicato, G1
Stadler, KL1
Ober, CP1
Feeney, DA1
Jessen, CR1
Wataya, T1
Ishizaki, R1
Kitagawa, M1
Tashiro, Y1
Yamamoto, T3
Isobe, T2
Akutsu, H2
Masumoto, T2
Ando, H1
Sato, E1
Takada, K1
Anno, I2
Matsumura, A2
Bourdillon, P1
Hlaihel, C1
Guyotat, J1
Guillotton, L1
Honnorat, J1
Ducray, F1
Cotton, F1
Stadlbauer, A6
Pichler, P1
Karl, M1
Brandner, S1
Lerch, C1
Renner, B1
Heinz, G1
Alam, MS1
Ahsan, H1
Sajjad, Z1
Beg, M1
Bhatti, U1
Enam, A1
Wasay, M1
Ranjith, G1
Parvathy, R1
Vikas, V1
Chandrasekharan, K1
Nair, S1
Wang, J1
Yin, H1
Panandikar, A1
Gandhi, V1
Sen, S1
Tang, C1
Guo, J2
Chen, H2
Yao, CJ2
Zhuang, DX2
Wang, Y2
Tang, WJ1
Ren, G2
Yao, Y1
Wu, JS2
Mao, Y1
Zhou, LF1
Ghasemi, K1
Khanmohammadi, M1
Saligheh Rad, H1
Tong, T1
Yang, Z1
Chen, JW1
Zhu, J1
Yao, Z1
Lotumolo, A2
Caivano, R2
Rabasco, P2
Iannelli, G1
Villonio, A2
D' Antuono, F1
Gioioso, M1
Zandolino, A2
Macarini, L2
Guglielmi, G1
Cammarota, A2
Wang, Q1
Zhang, H1
Wu, C1
Zhu, W1
Chen, X1
Xu, B1
Pospisil, P3
Kazda, T3
Bulik, M4
Dobiaskova, M2
Burkon, P2
Hynkova, L2
Slampa, P3
Jancalek, R4
Lin, CP1
Wang, TL1
Qin, ZY1
Chuang, MT1
Liu, YS1
Tsai, YS1
Chen, YC1
Wang, CK1
Jarmusch, AK1
Pirro, V1
Baird, Z1
Hattab, EM1
Cohen-Gadol, AA1
Cooks, RG1
Cordova, JS1
Shu, HK1
Liang, Z1
Cooper, LA1
Holder, CA1
Olson, JJ1
Kairdolf, B1
Schreibmann, E1
Neill, SG1
Hadjipanayis, CG1
Carrera, I1
Richter, H1
Beckmann, K1
Meier, D1
Dennler, M1
Kircher, PR1
Xu, YJ1
Cui, Y1
Li, HX1
Shi, WQ1
Li, FY1
Wang, JZ1
Zeng, QS3
Lakomy, R1
Smrcka, M1
Patriarca, L1
D'Orazio, F1
Di Cesare, E1
Splendiani, A1
Heiland, DH1
Mader, I2
Schlosser, P1
Pfeifer, D1
Carro, MS1
Lange, T1
Schwarzwald, R1
Vasilikos, I1
Urbach, H1
Weyerbrock, A1
Yu, W1
Suliburk, J1
Eberlin, LS1
Gilberto González, R1
Tamrazi, B1
Nelson, MD1
Blüml, S1
Nelson, SJ15
Li, Y3
Lupo, JM1
Olson, M1
Crane, JC1
Molinaro, A1
Roy, R2
Clarke, J1
Butowski, N1
Prados, M1
Cha, S5
Chang, SM5
Rios, C1
Motola-Kuba, D1
Matus-Santos, J1
Villa, AR1
Laack, NN1
Artzi, M1
Liberman, G1
Vaisman, N1
Vitinshtein, F1
Aizenstein, O1
Ben Bashat, D1
Boonzaier, NR1
Larkin, TJ1
Matys, T1
van der Hoorn, A1
Yan, JL1
Price, SJ1
Simões, RV1
Martinez-Aranda, A1
Martín, B1
Cerdán, S2
Sierra, A1
Arús, C2
Sankar, T1
Caramanos, Z3
Assina, R1
Villemure, JG3
Leblanc, R3
Langleben, A2
Arnold, DL5
Preul, MC3
Srinivasan, R1
Ratiney, H1
Lu, Y3
Su, Y1
Thakur, SB1
Karimi, S1
Du, S1
Sajda, P1
Huang, W1
Parra, LC1
Guillevin, R2
Menuel, C2
Sanson, M1
Hoang-Xuan, K2
Chiras, J2
Crawford, FW1
Khayal, IS1
McGue, C1
Saraswathy, S1
Pirzkall, A5
Lamborn, KR2
Berger, MS4
Douis, H1
Jafri, M1
Sherlala, K1
Majós, C1
Aguilera, C1
Alonso, J1
Julià-Sapé, M1
Castañer, S1
Sánchez, JJ1
Samitier, A1
León, A1
Rovira, A1
Balaji, R1
Ramachandran, K1
Smith, EA2
Carlos, RC2
Junck, LR1
Tsien, CI1
Elias, A2
Sundgren, PC4
Nagesh, V1
Tsien, C1
Junck, L2
Gomez Hassan, DM1
Lawrence, TS1
Chenevert, TL1
Rogers, L1
McKeever, P1
Cao, Y1
Kumar, V1
Chakrabarti, S1
Modi, M1
Sahoo, M1
Mazzoni, LN1
Belli, G1
Ginestroni, A1
Pratesi, A1
Agnoloni, S1
Diciotti, S1
Mascalchi, M1
Zierhut, ML1
Ozturk-Isik, E2
Chen, AP1
Park, I1
Vigneron, DB9
Blamek, S2
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van Leeuwen, P1
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Czech, T1
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Yang, XL1
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Boockvar, JA1
Mao, X2
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K Burkhardt, J1
Kesavabhotla, K1
Christos, P1
Riina, H1
Shungu, DC2
Tsiouris, AJ1
Mertens, K1
Acou, M1
Van den Broecke, C1
Nuyts, R1
Van Roost, D1
Achten, E1
Goethals, I1
Yao, C1
Zhuang, D1
Tang, W1
Wu, J1
Huang, F1
Zhou, L1
Gaudino, S1
Di Lella, GM1
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Lo Russo, VS1
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Quaglio, FR1
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Bjelan, M1
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Kvernmo, NA1
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Gulati, S1
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Vanicek, J1
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Mechl, M1
Gmeiner, M1
Sonnberger, M1
Wurm, G1
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Ali, ZS1
Lang, SS1
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D'Antuono, F1
Lancellotti, MI1
Oudkerk, M4
Nakaiso, M1
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Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Study About the Validity of MRS-guided Resection on Prognosis High-grade Gliomas[NCT02795364]50 participants (Anticipated)Interventional2016-06-30Not yet recruiting
Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206]12 participants (Anticipated)Observational2020-12-31Not yet recruiting
Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318]100 participants (Actual)Interventional2012-01-31Completed
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]Phase 1/Phase 20 participants (Actual)Interventional2015-12-31Withdrawn (stopped due to NIH funding resulted in new clinical trial)
Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788]55 participants (Anticipated)Observational2021-09-01Recruiting
Phase II Trial of Conventional Radiotherapy With Stereotactic Radiosurgery to High Risk Tumor Regions as Determined by Functional Imaging in Patients With Glioblastoma Multiforme[NCT00253448]Phase 235 participants (Actual)Interventional2002-12-31Completed
Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458]50 participants (Anticipated)Observational2020-06-01Recruiting
In Vivo Proton MR Spectroscopy of Brain Metastases Obtained at 1,5T and 3T.[NCT00184353]19 participants (Actual)Observational2003-11-30Completed
Ependymomics: Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents[NCT05151718]370 participants (Anticipated)Observational2021-09-30Recruiting
Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725]3,500 participants (Anticipated)Observational2021-10-11Recruiting
A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients With Primary and Metastatic Brain Tumors[NCT00001574]40 participants (Actual)Observational1997-03-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival After Treatment

Followed every 3 months for 2 years, every 6 months for 3 years, and annually thereafter for at least 5 years (NCT00253448)
Timeframe: Minimum of 5 years.

Interventionmonths (Median)
Entire CohortRTOG Glioma Recursive Partitioning Class 3 n=4RTOG Glioma Recursive Partitioning Class 4 n=13RTOG Glioma Recursive Partitioning Class 5 n=16RTOG Glioma Recursive Partitioning Class 6 n=2Patients receiving concurrent chemotherapyPatients who were not candidates for chemotherapy
Stereotactic Radiosurgery Plus Conventional Radiotherapy15.82218.712.53.920.811

Reviews

19 reviews available for aspartic acid and Brain Neoplasms

ArticleYear
Unique magnetic resonance spectroscopy profile of intracranial meningiomas compared to gliomas: a systematic review.
    Acta neurologica Belgica, 2023, Volume: 123, Issue:6

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Spectr

2023
Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2023, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr

2023
The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis.
    European radiology, 2016, Volume: 26, Issue:8

    Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Databases, Factual; Glioma; Hum

2016
Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Hum

2016
Vanishing pineal mass in a young patient without therapy: Case report and review of the literature.
    The neuroradiology journal, 2016, Volume: 29, Issue:5

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Choline; Electroencephalography; Female; Glutamic Acid;

2016
Clinical magnetic resonance spectroscopy of the central nervous system.
    Handbook of clinical neurology, 2016, Volume: 135

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Central Nervous System; Choline; Creatine; Glutamic

2016
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2009, Volume: 53, Issue:6

    Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In

2009
[Magnetic resonance spectroscopy for cerebral imaging].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:6

    Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea

2010
The role of MR spectroscopy in neurooncology.
    Prilozi, 2012, Volume: 33, Issue:1

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Inosi

2012
Potential of MR spectroscopy for assessment of glioma grading.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:2

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol

2013
Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Choline; Diagnosis,

2013
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
    The International journal of neuroscience, 2013, Volume: 123, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ

2013
MR spectroscopy of brain tumors.
    Magnetic resonance imaging clinics of North America, 2003, Volume: 11, Issue:3

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Humans; Lipids; Magnetic Resonance Spectro

2003
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
    Seminars in oncology, 2004, Volume: 31, Issue:5

    Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans

2004
Proton MR spectroscopy of the brain at 3 T: an update.
    European radiology, 2007, Volume: 17, Issue:7

    Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Cortex; Choline; Creatine

2007
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma.
    Neurosurgery, 1997, Volume: 40, Issue:2

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine;

1997
[Mapping of cerebral metabolism on cerebral disorders using multi-slice proton magnetic resonance spectroscopic imaging].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:7

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Cerebral Infarction; Choline; Creatinine; Humans; Lactates; M

1997
Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:3

    Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Choline; Humans; Infant; Lacti

1998
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
    Journal of neuro-oncology, 1992, Volume: 13, Issue:2

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates;

1992

Trials

14 trials available for aspartic acid and Brain Neoplasms

ArticleYear
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.
    Neuro-oncology, 2013, Volume: 15, Issue:7

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Be

2013
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
    International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea

2014
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
    Journal of neuro-oncology, 2008, Volume: 90, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis

2008
Phase II trial of radiosurgery to magnetic resonance spectroscopy-defined high-risk tumor volumes in patients with glioblastoma multiforme.
    International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Combined Modality Therapy;

2012
Metabolic response of glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab: a proton MR spectroscopic imaging study.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:11

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Aspartic Acid; Bevacizumab; Brain;

2012
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.
    NMR in biomedicine, 2003, Volume: 16, Issue:1

    Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid

2003
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings.
    Neuroradiology, 2004, Volume: 46, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli

2004
Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas.
    Journal of neurosurgery, 2007, Volume: 106, Issue:4

    Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Pro

2007
[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas].
    Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:2A

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Chol

2007
Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury.
    Journal of neuro-oncology, 2007, Volume: 84, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fema

2007
Evaluation of invasiveness of astrocytoma using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2.
    Neuroradiology, 2007, Volume: 49, Issue:11

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Female; Hum

2007
Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study.
    International journal of radiation oncology, biology, physics, 2008, Mar-01, Volume: 70, Issue:3

    Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Magnetic Resonance Ima

2008
[Quantification of brain metabolites by 1H spectroscopy using cyclohexane as an external reference].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1996, Volume: 56, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Cyclohexanes; Female; Humans;

1996
Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy.
    Neurology, 2000, Apr-11, Volume: 54, Issue:7

    Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain Neoplasms; Child; C

2000

Other Studies

279 other studies available for aspartic acid and Brain Neoplasms

ArticleYear
Magnetic resonance spectroscopy - its added value in brain glioma multiparametric assessment.
    Bratislavske lekarske listy, 2021, Volume: 122, Issue:10

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectro

2021
N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro.
    Life sciences, 2021, Dec-01, Volume: 286

    Topics: Apoptosis; Aspartic Acid; Brain Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression

2021
Revisiting the use of proton magnetic resonance spectroscopy in distinguishing between primary and secondary malignant tumors of the central nervous system.
    The neuroradiology journal, 2022, Volume: 35, Issue:5

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Proton M

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Is pre-radiotherapy metabolic heterogeneity of glioblastoma predictive of progression-free survival?
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023, Volume: 183

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magnetic Resonance Imaging;

2023
2-D magnetic resonance spectroscopic imaging of the pediatric brain using compressed sensing.
    Pediatric radiology, 2019, Volume: 49, Issue:13

    Topics: Adolescent; Age Factors; Aspartic Acid; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Co

2019
A method for cranial target delineation in radiotherapy treatment planning aided by single-voxel magnetic resonance spectroscopy: evaluation using a custom-designed gel-based phantom and simulations.
    The British journal of radiology, 2019, Volume: 92, Issue:1104

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Magnetic Resonance Spect

2019
The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020, Volume: 30, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Isocitrate

2020
Neurometabolic Remodeling in Chronic Hiv Infection: a Five-Year Follow-up Multi-Voxel Mrs Study.
    Scientific reports, 2019, 12-24, Volume: 9, Issue:1

    Topics: Adult; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Brain Neoplasms; Cell Communication; Cell

2019
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:3

    Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err

2020
Correlations between DTI-derived metrics and MRS metabolites in tumour regions of glioblastoma: a pilot study.
    Radiology and oncology, 2020, 09-29, Volume: 54, Issue:4

    Topics: Anisotropy; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Contrast Media; Creatine; Di

2020
Multimodal MR Features of 8 Cases of Epithelioid Glioblastoma.
    BioMed research international, 2020, Volume: 2020

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusi

2020
Hyperpolarized
    Scientific reports, 2021, 03-11, Volume: 11, Issue:1

    Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma

2021
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.
    Scientific reports, 2021, 04-12, Volume: 11, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytes; Brain Neoplasms; Female; Glioma; Glutamic

2021
Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.
    BioMed research international, 2021, Volume: 2021

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Cognitive Dysfunction; Creatine; Early Diagnosis;

2021
[Magnetic resonance spectroscopy of brain tumors].
    Der Radiologe, 2017, Volume: 57, Issue:6

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging

2017
Mapping an Extended Neurochemical Profile at 3 and 7 T Using Accelerated High-Resolution Proton Magnetic Resonance Spectroscopic Imaging.
    Investigative radiology, 2017, Volume: 52, Issue:10

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Female; Humans; Magnetic Resonance Spectroscopy; Male;

2017
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
    The British journal of radiology, 2017, Volume: 90, Issue:1075

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res

2017
Exploring the optimal ratio of d-glucose/l-aspartic acid for targeting carbon dots toward brain tumor cells.
    Materials science & engineering. C, Materials for biological applications, 2018, Apr-01, Volume: 85

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon; Cell Line, Tumor; Flow Cytometry; Glucose; Mice; Ph

2018
In vivo characterization of brain metabolism by
    International journal of cancer, 2018, 07-01, Volume: 143, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Brain; Brain Neoplasms; Cell Line, Tum

2018
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2.
    Acta radiologica (Stockholm, Sweden : 1987), 2019, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Proliferation; Chil

2019
Variation of T
    Journal of magnetic resonance imaging : JMRI, 2019, Volume: 49, Issue:1

    Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Child; Choline; Creatine; Female; Humans; Magnet

2019
Imaging biomarkers from multiparametric magnetic resonance imaging are associated with survival outcomes in patients with brain metastases from breast cancer.
    European radiology, 2018, Volume: 28, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Breast Neopla

2018
On the relation between MR spectroscopy features and the distance to MRI-visible solid tumor in GBM patients.
    Magnetic resonance in medicine, 2018, Volume: 80, Issue:6

    Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Healthy Volunteers; Hu

2018
Lesion segmentation for MR spectroscopic imaging using the convolution difference method.
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:3

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Computer Simulation; Glio

2019
The Role of Single Voxel MR Spectroscopy, T2 Relaxation Time and Apparent Diffusion Coefficient in Determining the Cellularity of Brain Tumors by MATLAB Software
    Asian Pacific journal of cancer prevention : APJCP, 2018, Oct-26, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Creatine; Cross-Sec

2018
Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting.
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:5

    Topics: Algorithms; Artifacts; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Computer Graphics; Cr

2019
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
    NMR in biomedicine, 2013, Volume: 26, Issue:10

    Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Gl

2013
Utility of proton MR spectroscopy for differentiating typical and atypical primary central nervous system lymphomas from tumefactive demyelinating lesions.
    AJNR. American journal of neuroradiology, 2014, Volume: 35, Issue:2

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Demyelinating Diseases; Diagnosis, Differential

2014
Primary central neurocytoma of the mesencephalic tectum in a pediatric patient.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014, Volume: 30, Issue:5

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Humans; Magnetic Resonance Imaging; Magnetic Resonance S

2014
Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions.
    Vojnosanitetski pregled, 2013, Volume: 70, Issue:7

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diffusion

2013
Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.
    International journal of cancer, 2014, Mar-15, Volume: 134, Issue:6

    Topics: Amidohydrolases; Animals; Antifungal Agents; Aspartic Acid; Astrocytes; Brain; Brain Neoplasms; Cell

2014
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection.
    International journal of computer assisted radiology and surgery, 2014, Volume: 9, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Image

2014
MR imaging of intracranial hemangiopericytomas.
    Journal of neuroradiology = Journal de neuroradiologie, 2014, Volume: 41, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatine; Female; Hema

2014
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
    International journal of radiation oncology, biology, physics, 2014, Sep-01, Volume: 90, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C

2014
Delineation of gliomas using radial metabolite indexing.
    NMR in biomedicine, 2014, Volume: 27, Issue:9

    Topics: Algorithms; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Diagnosis, Computer-Assisted

2014
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
    Magnetic resonance in medicine, 2015, Volume: 73, Issue:6

    Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female;

2015
Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes.
    International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Brain Mapping; Brain Neoplasms; Choline; Creatine; F

2014
Pilocytic astrocytoma with anaplastic features presenting good long-term clinical course after surgery alone: a case report.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015, Volume: 31, Issue:1

    Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Humans; Magnetic Resonance Imaging; Magnetic Res

2015
Multivoxel proton magnetic resonance spectroscopy of inflammatory and neoplastic lesions of the canine brain at 3.0 T.
    American journal of veterinary research, 2014, Volume: 75, Issue:11

    Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis,

2014
Germinoma in the bilateral basal ganglia presented with cognitive deterioration.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015, Volume: 31, Issue:6

    Topics: Adolescent; Aspartic Acid; Basal Ganglia; Brain Neoplasms; Cognition Disorders; Creatine; Germinoma;

2015
Influence of echo time in quantitative proton MR spectroscopy using LCModel.
    Magnetic resonance imaging, 2015, Volume: 33, Issue:5

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer

2015
Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status.
    Journal of neuro-oncology, 2015, Volume: 122, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Chromosome Deletion; Chromosomes, Human, Pair

2015
Quantification of serial changes in cerebral blood volume and metabolism in patients with recurrent glioblastoma undergoing antiangiogenic therapy.
    European journal of radiology, 2015, Volume: 84, Issue:6

    Topics: Angiogenesis Inhibitors; Aspartic Acid; Bevacizumab; Blood Volume; Brain; Brain Mapping; Brain Neopl

2015
Magnetic resonance spectroscopy of enhancing cerebral lesions: analysis of 78 histopathology proven cases.
    JPMA. The Journal of the Pakistan Medical Association, 2014, Volume: 64, Issue:10

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine;

2014
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
    The neuroradiology journal, 2015, Volume: 28, Issue:2

    Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre

2015
Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug.
    International journal of oncology, 2015, Volume: 47, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Line, Tumo

2015
Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Codon, Nonsense; DNA

2015
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
    Magnetic resonance in chemistry : MRC, 2016, Volume: 54, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra

2016
Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma.
    Oncotarget, 2015, Oct-13, Volume: 6, Issue:31

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Choline; Diagnosis, Differe

2015
Comparison between magnetic resonance spectroscopy and diffusion weighted imaging in the evaluation of gliomas response after treatment.
    European journal of radiology, 2015, Volume: 84, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Diffusion Magnetic Resonanc

2015
Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences.
    Radiation oncology (London, England), 2015, Oct-17, Volume: 10

    Topics: Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Cognition Disorders; Cranial Irradiation; Female;

2015
Metabolic approach for tumor delineation in glioma surgery: 3D MR spectroscopy image-guided resection.
    Journal of neurosurgery, 2016, Volume: 124, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diffusion Tensor Imaging; Feasibility S

2016
Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Feb-09, Volume: 113, Issue:6

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Cell Differentiation; Glioma; Gray Matter; Humans; Lipid Meta

2016
Whole-brain spectroscopic MRI biomarkers identify infiltrating margins in glioblastoma patients.
    Neuro-oncology, 2016, Volume: 18, Issue:8

    Topics: Aminolevulinic Acid; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Count; Choline; Disease

2016
Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla.
    American journal of veterinary research, 2016, Volume: 77, Issue:5

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Creatine; Dog Diseases; Dogs; Female;

2016
Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro.
    Magnetic resonance imaging, 2016, Volume: 34, Issue:8

    Topics: Aspartic Acid; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Choline; C

2016
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging.
    NeuroImage. Clinical, 2016, Volume: 11

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance I

2016
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme.
    Scientific reports, 2016, 06-28, Volume: 6

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Computational Biology; Creatine; Fem

2016
Will Ambient Ionization Mass Spectrometry Become an Integral Technology in the Operating Room of the Future?
    Clinical chemistry, 2016, Volume: 62, Issue:9

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Clinical Laboratory Techniques; Humans; Operating

2016
MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA.
    Magnetic resonance in medicine, 2017, Volume: 78, Issue:2

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Humans; Inf

2017
Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.
    Journal of neuro-oncology, 2016, Volume: 130, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Chol

2016
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
    The British journal of radiology, 2016, Volume: 89, Issue:1067

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre

2016
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, Volume: 122, Issue:3

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Cognitive Dysfunction; Cranial Irradiation; Female; Foll

2017
Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors:
    Journal of neuro-oncology, 2017, Volume: 132, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Cere

2017
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.
    Radiology, 2017, Volume: 284, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I

2017
Preliminary characterization of an experimental breast cancer cells brain metastasis mouse model by MRI/MRS.
    Magma (New York, N.Y.), 2008, Volume: 21, Issue:4

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Cell Line, Tumor; Choline; Creatine; Female; Humans; Magnet

2008
Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T.
    Journal of magnetic resonance imaging : JMRI, 2008, Volume: 28, Issue:2

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Gliom

2008
Spectrum separation resolves partial-volume effect of MRSI as demonstrated on brain tumor scans.
    NMR in biomedicine, 2008, Volume: 21, Issue:10

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Humans; Image Enhancement; Image Interpretation

2008
[The advantage of photon magnetic resonance spectroscopy in brain tumors].
    Revue neurologique, 2008, Volume: 164 Spec No 3

    Topics: Abnormalities, Radiation-Induced; Aspartic Acid; Brain Neoplasms; Cell Proliferation; Choline; Creat

2008
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.
    Journal of neuro-oncology, 2009, Volume: 91, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti

2009
Bilateral thalamic glioma.
    Archives of neurology, 2008, Volume: 65, Issue:12

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imagin

2008
Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses.
    AJNR. American journal of neuroradiology, 2009, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Diagnosis, Differe

2009
Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009, Volume: 25, Issue:4

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diagnosis, Differential; Gangliogli

2009
Developing a clinical decision model: MR spectroscopy to differentiate between recurrent tumor and radiation change in patients with new contrast-enhancing lesions.
    AJR. American journal of roentgenology, 2009, Volume: 192, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast

2009
Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study.
    Journal of magnetic resonance imaging : JMRI, 2009, Volume: 29, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Magnetic Reso

2009
Late-onset obsessive compulsive disorder associated with possible gliomatosis cerebri.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Aged; Anticonvulsants; Aspartic Acid; Brain Neoplasms; Choline; Corpus Callosum; Dominance, Cerebral

2009
Computation of brain metabolite ratios in single-voxel proton MR spectroscopy: comparison between semiautomatic and automatic software.
    La Radiologia medica, 2010, Volume: 115, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Image Processing, C

2010
(1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques.
    Journal of magnetic resonance imaging : JMRI, 2009, Volume: 30, Issue:3

    Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Contrast Media; Creatine; Echo-Planar

2009
MR spectroscopic evaluation of brain tissue damage after treatment for pediatric brain tumors.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Adolescent; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Ependymoma; Female; Gli

2010
Magnetic resonance spectroscopic evaluation of brain tissue metabolism after irradiation for pediatric brain tumors in long-term survivors: a report of two cases.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Humans; Lactic Acid; Ma

2010
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
    Neuroradiology, 2010, Volume: 52, Issue:4

    Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr

2010
MR spectroscopy for differentiation of recurrent glioma from radiation-induced changes.
    AJR. American journal of roentgenology, 2009, Volume: 193, Issue:6

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast

2009
Spatial spectral modeling for robust MRSI.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2009, Volume: 2009

    Topics: Aspartic Acid; Brain Neoplasms; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imag

2009
Grid-free interactive and automated data processing for MR chemical shift imaging data.
    Magma (New York, N.Y.), 2010, Volume: 23, Issue:1

    Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Elect

2010
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media;

2010
Response to article "Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors".
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc

2010
Response to a letter by Paul E. Sijens.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc

2010
Gliomatosis cerebri, imaging findings of 12 cases.
    Journal of neuroradiology = Journal de neuroradiologie, 2010, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Child; Choline; Creatine

2010
A clinical and magnetic resonance spectroscopy study of a brain tumor in a patient with segmental neurofibromatosis.
    Neuro-Chirurgie, 2010, Volume: 56, Issue:4

    Topics: Adolescent; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Lactates; Ma

2010
Magnetic resonance spectroscopic imaging for visualization of the infiltration zone of glioma.
    Central European neurosurgery, 2011, Volume: 72, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Choline; Data Interpretation, Statistica

2011
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas.
    European journal of radiology, 2011, Volume: 80, Issue:2

    Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im

2011
N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas.
    Magnetic resonance imaging, 2010, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Diagn

2010
Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas.
    Journal of neurology, 2011, Volume: 258, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain Neoplasms; Cerebrovas

2011
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas?
    Investigative radiology, 2010, Volume: 45, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Contras

2010
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy.
    Magnetic resonance imaging, 2011, Volume: 29, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H

2011
Influence of brain tumors on the MR spectra of healthy brain tissue.
    Magnetic resonance in medicine, 2011, Volume: 65, Issue:1

    Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Neoplasms; Female; Humans; Magnetic Resonance

2011
Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement.
    Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; H

2011
[Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma].
    No shinkei geka. Neurological surgery, 2011, Volume: 39, Issue:5

    Topics: Adult; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; F

2011
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.
    Neurochemical research, 2011, Volume: 36, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet,

2011
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.
    British journal of cancer, 2011, Jun-07, Volume: 104, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; D

2011
Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging.
    Neuro-oncology, 2011, Volume: 13, Issue:8

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Brain Stem Neoplasms; Child; Child, Preschool; Ch

2011
Slowly progressive Parkinson syndrome due to thalamic butterfly astrocytoma.
    Neurology, 2011, Jul-26, Volume: 77, Issue:4

    Topics: Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Brain Stem; Choline; Glial Fibrillary Acidic Prot

2011
MR spectroscopy using normalized and non-normalized metabolite ratios for differentiating recurrent brain tumor from radiation injury.
    Academic radiology, 2011, Volume: 18, Issue:9

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Diagn

2011
Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results.
    Journal of neuro-oncology, 2012, Volume: 106, Issue:3

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studie

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
Compressive sensing could accelerate 1H MR metabolic imaging in the clinic.
    Radiology, 2012, Volume: 262, Issue:3

    Topics: Algorithms; Analysis of Variance; Aspartic Acid; Brain Neoplasms; Choline; Citric Acid; Creatine; Da

2012
N-acetyl peak in proton MR spectroscopy of metastatic mucinous adenocarcinoma of brain.
    Clinical neuroradiology, 2013, Volume: 23, Issue:2

    Topics: Adenocarcinoma, Mucinous; Adult; Aspartic Acid; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms;

2013
Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:8

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Fluorodeoxy

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
Magnetic resonance imaging of solitary brain metastases: main findings of nonmorphological sequences.
    La Radiologia medica, 2012, Volume: 117, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Blood Volume; Brain

2012
Multimodal MR imaging findings of a congenital glioblastoma multiforme.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Volume: 28, Issue:11

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Infant; Magnetic Resonance Imag

2012
Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas.
    Turkish neurosurgery, 2012, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Anisotropy; Aspartic Acid; Brain Neoplasms; Cerebral Cortex; Child; Choline

2012
Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T.
    Cancer imaging : the official publication of the International Cancer Imaging Society, 2012, Oct-26, Volume: 12

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, D

2012
Differentiating diffuse World Health Organization grade II and IV astrocytomas with ex vivo magnetic resonance spectroscopy.
    Neurosurgery, 2013, Volume: 72, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Fema

2013
Conservative management of presumed low-grade gliomas in the asymptomatic pediatric population.
    World neurosurgery, 2014, Volume: 81, Issue:2

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Asymptomatic Diseases; Brain Neoplasms; Child; Child, Presch

2014
1H chemical shift imaging characterization of human brain tumor and edema.
    European radiology, 2002, Volume: 12, Issue:8

    Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Choline; Creatine; Humans; Hydrogen; Magnetic Resonance

2002
Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports.
    Neurologia medico-chirurgica, 2002, Volume: 42, Issue:8

    Topics: Acetates; Adult; Amino Acids; Aspartic Acid; Brain Abscess; Brain Neoplasms; Diagnosis, Differential

2002
Proton MR spectroscopy of tumefactive demyelinating lesions.
    AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:8

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Demyelinating Diseases; Diagnosis, Different

2002
The contribution of proton magnetic resonance spectroscopy (1HMRS) to clinical brain tumour diagnosis.
    British journal of neurosurgery, 2002, Volume: 16, Issue:4

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatinine; Humans; Inositol; Magn

2002
Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence.
    Journal of neurosurgery, 2002, Volume: 97, Issue:4

    Topics: Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Spectroscopy; Pr

2002
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2003, Volume: 49, Issue:2

    Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi

2003
High-resolution 3D proton spectroscopic imaging of the human brain at 3 T: SNR issues and application for anatomy-matched voxel sizes.
    Magnetic resonance in medicine, 2003, Volume: 49, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Imaging, Three-Dime

2003
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat

2003
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
    Annales de medecine interne, 2002, Volume: 153, Issue:8

    Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia

2002
1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife.
    European radiology, 2003, Volume: 13, Issue:5

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Fo

2003
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma.
    The American journal of surgical pathology, 2003, Volume: 27, Issue:7

    Topics: Antigens, CD; Antigens, Surface; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Nucleus; Ch

2003
1H-MR spectroscopy of normal brain tissue before and after postoperative radiotherapy because of primary brain tumors.
    International journal of radiation oncology, biology, physics, 2003, Aug-01, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Combined Modality Therapy; Female; Humans;

2003
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
    Journal of Korean medical science, 2003, Volume: 18, Issue:4

    Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain

2003
Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy.
    Neuroradiology, 2004, Volume: 46, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Astrocytoma; Brain Neoplasms;

2004
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
    Analytical chemistry, 2003, Oct-15, Volume: 75, Issue:20

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc

2003
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
    International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyu

2004
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
    Der Radiologe, 2003, Volume: 43, Issue:12

    Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh

2003
Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors.
    Cancer, 2004, Mar-15, Volume: 100, Issue:6

    Topics: Adolescent; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Disea

2004
1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.
    Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:4

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Dose-Response Relationshi

2004
Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume.
    Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Blood Volume; Brain Neoplasms; Choline; Glioblastoma; Humans

2004
Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlCl single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging.
    Journal of neurosurgery, 2004, Volume: 100, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Contrast Media; Fema

2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; C

2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:7

    Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr

2004
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
    Journal of neurosurgery, 2004, Volume: 101, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor

2004
Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2005, Volume: 21, Issue:5

    Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Child, Preschool; Choline; Creatine; Female; Humans; In

2005
Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas.
    NeuroImage, 2004, Volume: 23, Issue:2

    Topics: Adult; Algorithms; Aspartic Acid; Astrocytoma; Automation; Biopsy; Brain Chemistry; Brain Mapping; B

2004
Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Femal

2004
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
    Academic radiology, 2005, Volume: 12, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin

2005
Proton MRS of the peritumoral brain.
    Journal of the neurological sciences, 2005, Feb-15, Volume: 228, Issue:2

    Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Edema; Brain Neoplasms; Epilepsy; Female; Huma

2005
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background.
    Brain tumor pathology, 2004, Volume: 21, Issue:1

    Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona

2004
Early metabolic changes in metastatic brain tumors after Gamma Knife radiosurgery: 1H-MRS study.
    Brain tumor pathology, 2004, Volume: 21, Issue:2

    Topics: Aged; Aspartic Acid; Brain Neoplasms; Creatine; Female; Glycerylphosphorylcholine; Humans; Lactic Ac

2004
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Cho

2005
Spectroscopy and navigation.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Image Processing, Comput

2005
Proton magnetic resonance spectroscopic imaging integrated into image-guided surgery: correlation to standard magnetic resonance imaging and tumor cell density.
    Neurosurgery, 2005, Volume: 56, Issue:2 Suppl

    Topics: Algorithms; Aspartic Acid; Biopsy; Brain Neoplasms; Cell Count; Choline; Feasibility Studies; Glioma

2005
Characterization of brain tumors by MRS, DWI and Ki-67 labeling index.
    Journal of neuro-oncology, 2005, Volume: 72, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cell Proliferation; Choline; Creatinine; Diffusion Magn

2005
[A case of high grade astrocytoma arising in the hand area of precentral gyrus].
    No to shinkei = Brain and nerve, 2005, Volume: 57, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Astrocytoma; Brain Neoplasms;

2005
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
    Journal of neuro-oncology, 2006, Volume: 76, Issue:2

    Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv

2006
Can MR spectroscopy ever be simple and effective?
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:9

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Humans; Magnetic Resonance Spectroscopy

2005
Evaluation of treatment-induced cerebral white matter injury by using diffusion-tensor MR imaging: initial experience.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:9

    Topics: Adult; Aged; Anisotropy; Antineoplastic Agents; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplas

2005
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
    European journal of radiology, 2005, Volume: 56, Issue:2

    Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio

2005
Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy.
    AJR. American journal of roentgenology, 2005, Volume: 185, Issue:6

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast Media;

2005
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
    General physiology and biophysics, 2005, Volume: 24, Issue:3

    Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla

2005
Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri.
    Acta radiologica (Stockholm, Sweden : 1987), 2005, Volume: 46, Issue:6

    Topics: Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Magnetic

2005
Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging.
    Radiology, 2006, Volume: 238, Issue:3

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female;

2006
In vivo research in astrocytoma cell proliferation with 1H-magnetic resonance spectroscopy: correlation with histopathology and immunohistochemistry.
    Neuroradiology, 2006, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Choline; Creatine; Fema

2006
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2006, Volume: 178, Issue:6

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined

2006
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
    Neuroradiology, 2006, Volume: 48, Issue:9

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio

2006
Clinical 1H magnetic resonance spectroscopy of brain metastases at 1.5T and 3T.
    Acta radiologica (Stockholm, Sweden : 1987), 2006, Volume: 47, Issue:5

    Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Humans; Magnetic Resonance Spectro

2006
Quantitation of NAA in the brain by magnetic resonance spectroscopy.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Humans; Magnetic Resonance Spectroscopy; Mat

2006
Leukoencephalopathy with bilateral anterior temporal lobe cysts.
    Journal of child neurology, 2006, Volume: 21, Issue:5

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Central Nervous System Cysts; Child; Child, Preschool; F

2006
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma;

2006
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre

2006
Long-term normal-appearing brain tissue monitoring after irradiation using proton magnetic resonance spectroscopy in vivo: statistical analysis of a large group of patients.
    International journal of radiation oncology, biology, physics, 2006, Nov-01, Volume: 66, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Blood-Brain Barrier; Brain; Brain Neoplasms; Choline; Creatine; Female;

2006
Comments and controversies: magnetic resonance spectroscopy and gliomas.
    Cancer imaging : the official publication of the International Cancer Imaging Society, 2006, Sep-07, Volume: 6

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy;

2006
Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile.
    International journal of clinical oncology, 2006, Volume: 11, Issue:5

    Topics: Aged; Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Evalua

2006
Short echo time 1 H magnetic resonance spectroscopy of childhood brain tumours.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:2

    Topics: Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Female; Humans; Hydrogen

2007
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging.
    International journal of radiation oncology, biology, physics, 2007, May-01, Volume: 68, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn

2007
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
    AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases;

2007
3.0-T functional brain imaging: a 5-year experience.
    La Radiologia medica, 2007, Volume: 112, Issue:1

    Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Arteries; Cerebral Cortex

2007
1H MR spectroscopy in the assessment of gliomatosis cerebri.
    AJR. American journal of roentgenology, 2007, Volume: 188, Issue:3

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Magn

2007
Changes in fiber integrity, diffusivity, and metabolism of the pyramidal tract adjacent to gliomas: a quantitative diffusion tensor fiber tracking and MR spectroscopic imaging study.
    AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Creatine; Diffusion Magnetic Resonance Ima

2007
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging.
    Neuroradiology, 2007, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline

2007
3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil.
    Journal of magnetic resonance imaging : JMRI, 2007, Volume: 26, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female; Humans

2007
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
    European neurology, 2007, Volume: 58, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma;

2007
Low-grade glioma: correlation of short echo time 1H-MR spectroscopy with 23Na MR imaging.
    AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Magnetic Resonance Imaging; Ma

2008
Giant infantile gliosarcoma: magnetic resonance imaging findings.
    Journal of child neurology, 2008, Volume: 23, Issue:8

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Child, Preschool; Choline; Creatinine; Female; Gliosarcoma; H

2008
Mimicking the human expert: pattern recognition for an automated assessment of data quality in MR spectroscopic images.
    Magnetic resonance in medicine, 2008, Volume: 59, Issue:6

    Topics: Area Under Curve; Artifacts; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Expert Systems; Huma

2008
Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopy.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2008, Volume: 18, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti

2008
Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and intracerebral tumor.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Aspartic Acid; Brain Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infus

1980
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
    Magnetic resonance in medicine, 1995, Volume: 34, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan

1995
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
    Radiology, 1995, Volume: 197, Issue:2

    Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea

1995
Toxoplasmosis and primary central nervous system lymphoma in HIV infection: diagnosis with MR spectroscopy.
    Radiology, 1995, Volume: 197, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dia

1995
Analysis of brain tumors using 1H magnetic resonance spectroscopy.
    Surgical neurology, 1995, Volume: 44, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magneti

1995
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea

1995
Radiation-induced changes in human brain metabolites as studied by 1H nuclear magnetic resonance spectroscopy in vivo.
    International journal of radiation oncology, biology, physics, 1995, Oct-15, Volume: 33, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Female; Humans; Magnetic Resona

1995
Spectral editing with adiabatic pulses.
    Journal of magnetic resonance. Series B, 1995, Volume: 109, Issue:2

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Choline; Creatine; Feasibility Studies; Gl

1995
1H MR spectroscopy in patients with metastatic brain tumors: a multicenter study.
    Magnetic resonance in medicine, 1995, Volume: 33, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; Humans; Mag

1995
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:3

    Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Ependymoma; Glioma; Humans; Magnetic

1995
Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma.
    Magnetic resonance in medicine, 1994, Volume: 32, Issue:5

    Topics: Adult; Aspartic Acid; Brain Neoplasms; Breast Neoplasms; Carcinoma; Choline; Contrast Media; Creatin

1994
Proton magnetic resonance spectroscopy of brain tumors: an in vitro study.
    Neurosurgery, 1994, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; C

1994
Brain abscess observed by localized proton magnetic resonance spectroscopy.
    Magnetic resonance imaging, 1994, Volume: 12, Issue:8

    Topics: Aspartic Acid; Brain Abscess; Brain Chemistry; Brain Neoplasms; Choline; Contrast Media; Creatine; D

1994
Incorporation of lactate measurement in multi-spin-echo proton spectroscopic imaging.
    Magnetic resonance in medicine, 1995, Volume: 33, Issue:1

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Image Processing,

1995
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di

1995
High-resolution 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro.
    Journal of neurosurgery, 1994, Volume: 81, Issue:3

    Topics: Adolescent; Alanine; Amino Acids; Animals; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cerebellar N

1994
[Clinical suitability of brain tumor patients for single voxel protein MR spectroscopy].
    Rontgenpraxis; Zeitschrift fur radiologische Technik, 1994, Volume: 47, Issue:7

    Topics: Aspartic Acid; Brain Neoplasms; Cell Division; Choline; Creatine; Energy Metabolism; Humans; Lactate

1994
Effects of therapy on the 1H NMR spectrum of a human glioma line.
    Magnetic resonance imaging, 1994, Volume: 12, Issue:6

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spe

1994
Proton MR spectroscopy of experimental brain tumors in vivo.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho

1994
Response of non-Hodgkin lymphoma to radiation therapy: early and long-term assessment with H-1 MR spectroscopic imaging.
    Radiology, 1995, Volume: 194, Issue:1

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studies; Humans; Lipid Metaboli

1995
Localized proton spectroscopy of focal brain pathology in humans: significant effects of edema on spin-spin relaxation time.
    Magnetic resonance in medicine, 1994, Volume: 31, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Edema; Brain Ischemia; Brain Neoplasms; Cerebr

1994
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy.
    Journal of neuro-oncology, 1993, Volume: 17, Issue:1

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I

1993
Quantitative proton spectroscopy and histology of a canine brain tumor model.
    Magnetic resonance in medicine, 1993, Volume: 30, Issue:4

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag

1993
Incorporating lactate/lipid discrimination into a spectroscopic imaging sequence.
    Magnetic resonance in medicine, 1993, Volume: 30, Issue:1

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Cerebrovascular Disorders; Humans; Lactates; Lipids

1993
Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumours.
    NMR in biomedicine, 1995, Volume: 8, Issue:3

    Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellum; Creatine; Humans; Magnetic Resonance

1995
[Spectroscopic imaging of the brain. Examination technique and clinical applications].
    Der Nervenarzt, 1995, Volume: 66, Issue:12

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Energy M

1995
Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy.
    Nature medicine, 1996, Volume: 2, Issue:3

    Topics: Adult; Alanine; Aspartic Acid; Astrocytoma; Biomarkers; Brain; Brain Neoplasms; Choline; Creatine; D

1996
Single-voxel proton brain spectroscopy exam (PROBE/SV) in patients with primary brain tumors.
    AJR. American journal of roentgenology, 1996, Volume: 167, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Crea

1996
Reproducibility of metabolite peak areas in 1H MRS of brain.
    Magnetic resonance imaging, 1996, Volume: 14, Issue:3

    Topics: Adult; Analysis of Variance; Artifacts; Aspartic Acid; Brain; Brain Neoplasms; Cerebrovascular Disor

1996
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 1996, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal

1996
Intracranial tumors in children: small single-voxel proton MR spectroscopy using short- and long-echo sequences.
    Neuroradiology, 1996, Volume: 38, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatinine; Female; Gl

1996
Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human brain cancer. Unexpected inverse correlation between the changes in tumor choline level and post-gadolinium magnetic resonance imaging contrast.
    Investigative radiology, 1995, Volume: 30, Issue:12

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Follow-Up Studies; Four

1995
Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives.
    Journal of neurology, 1996, Volume: 243, Issue:10

    Topics: Adenoma; Aspartic Acid; Brain Neoplasms; Choline; Craniopharyngioma; Creatinine; Glioma; Humans; Lym

1996
1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:2

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Fourier Analysis; Gadolini

1997
Multivoxel proton MR spectroscopy and hemodynamic MR imaging of childhood brain tumors: preliminary observations.
    AJNR. American journal of neuroradiology, 1997, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Femal

1997
Brain tumors: localized H-1 MR spectroscopy at 0.5 T.
    Radiology, 1997, Volume: 204, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Case-Control Studi

1997
Early changes in peritumorous oedema and contralateral white matter after dexamethasone: a study using proton magnetic resonance spectroscopy.
    Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Aspartic Acid; Brain; Brain Edema; Brain Neoplasms; Choline; Creati

1997
[Metabolic imaging of human brain tumors: H-1 chemical shift imaging and PET].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:7

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Humans; Lactates; Magnetic Resonance Spectroscopy; P

1997
Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method.
    NMR in biomedicine, 1997, Volume: 10, Issue:1

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Evaluation Studies as Topic; Glioma; Humans; Imag

1997
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
    Journal of neurosurgery, 1997, Volume: 87, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas

1997
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
    Journal of neurosurgery, 1997, Volume: 87, Issue:4

    Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro

1997
Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy.
    AJNR. American journal of neuroradiology, 1997, Volume: 18, Issue:9

    Topics: Adult; Animals; Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Cranial Irradiation;

1997
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
    Acta radiologica (Stockholm, Sweden : 1987), 1997, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo

1997
Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy.
    International journal of radiation oncology, biology, physics, 1998, Jan-15, Volume: 40, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactic Acid; Magnet

1998
Application of proton chemical shift imaging in monitoring of gamma knife radiosurgery on brain tumors.
    Magnetic resonance imaging, 1998, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Humans; Lipids; Magnet

1998
Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Aspartic Acid; Brain; Brain Neoplasms; Child; Child, Presc

1998
In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1998, Volume: 133, Issue:2

    Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactic Acid; Lip

1998
Pediatric low-grade gliomas: prognosis with proton magnetic resonance spectroscopic imaging.
    Neurosurgery, 1998, Volume: 43, Issue:4

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Division; Child; Child, Prescho

1998
Intraoperative microdialysis and tissue-pO2 measurement in human glioma.
    Acta neurochirurgica. Supplement, 1998, Volume: 71

    Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Cell Death; Female; Frontal Lobe; Glioblastoma; Glutami

1998
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
    AJNR. American journal of neuroradiology, 1999, Volume: 20, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms;

1999
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla

1999
Three-dimensional multivoxel proton MR spectroscopy of the brain in children with neurofibromatosis type 1.
    AJNR. American journal of neuroradiology, 1999, Volume: 20, Issue:7

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine;

1999
Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS.
    Pediatric research, 1999, Volume: 46, Issue:4

    Topics: Adolescent; Age Factors; Aspartic Acid; Basal Ganglia; Brain; Brain Neoplasms; Cerebellum; Child; Ch

1999
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels.
    Neuroradiology, 1999, Volume: 41, Issue:9

    Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Glycine; Humans; Inositol; Magnetic Resonance

1999
Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy.
    Neurosurgery, 2000, Volume: 46, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Astro

2000
Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Fema

2000
MR spectroscopy in gliomatosis cerebri.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Choline; Creatine; Di

2000
Effect of voxel position on single-voxel MR spectroscopy findings.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio

2000
Discrimination between neoplastic and nonneoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosi

2000
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
    Pediatric neurology, 2000, Volume: 23, Issue:1

    Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms;

2000
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil

2000
An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma.
    Journal of magnetic resonance imaging : JMRI, 2001, Volume: 13, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Female; Glioma; Humans; Imaging, Three-Dimens

2001
In vivo proton magnetic resonance spectroscopy of brain tumors.
    Stereotactic and functional neurosurgery, 2000, Volume: 74, Issue:2

    Topics: Adult; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Brain; Brain Abscess; Brain Neoplasms; Choline

2000
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:4

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies;

2001
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
    Acta neurochirurgica, 2001, Volume: 143, Issue:1

    Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene

2001
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
    Journal of magnetic resonance imaging : JMRI, 2001, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop

2001
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
    Cancer research, 2001, Jul-15, Volume: 61, Issue:14

    Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma;

2001
Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors.
    Magnetic resonance in medicine, 2001, Volume: 46, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Computer Simulation; Creatine; Humans; Image Pr

2001
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
    European radiology, 2001, Volume: 11, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil

2001
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
    Cancer research, 2001, Sep-01, Volume: 61, Issue:17

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S

2001
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
    Neurosurgery, 2001, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr

2001
[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis].
    Revue neurologique, 2001, Volume: 157, Issue:8-9 Pt 1

    Topics: Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Energy Metabolism;

2001
Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor.
    NMR in biomedicine, 2002, Volume: 15, Issue:1

    Topics: Adult; Aspartic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Creatine; Diffusion; Fem

2002
High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging.
    Radiology, 2002, Volume: 222, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Bra

2002
Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions.
    Neuroradiology, 2002, Volume: 44, Issue:5

    Topics: Aspartic Acid; Brain Abscess; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Diagnosis, Di

2002
Effects of amino acids on calcium uptake by glial and neuroblastoma cells.
    Journal of neurobiology, 1979, Volume: 10, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Neoplasms; Calcimycin; Calcium; Clone Cells; Cricetinae;

1979
[Amino acid composition of ventricular and lumbar cerebrospinal fluid in brain tumors].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:6

    Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Glutamates;

1977
Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
    Cancer, 1992, May-01, Volume: 69, Issue:9

    Topics: Aspartic Acid; Base Sequence; Brain Neoplasms; Child; Child, Preschool; Codon; Female; Gene Expressi

1992
Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance.
    Radiology, 1992, Volume: 185, Issue:3

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glucose;

1992
Proton magnetic resonance spectroscopy of pediatric brain tumors.
    Neurosurgery, 1992, Volume: 31, Issue:2

    Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; Choline; Cre

1992
Human brain tumors: spectral patterns detected with localized H-1 MR spectroscopy.
    Radiology, 1992, Volume: 183, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Humans; Magnetic Resonance Spectroscopy; Midd

1992
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
    Annals of neurology, 1992, Volume: 31, Issue:3

    Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De

1992
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma.
    Magnetic resonance in medicine, 1992, Volume: 23, Issue:1

    Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic

1992
[The clinical application of multi-voxel 1H-CSI (chemical shift imaging) in brain tumors].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1991, Jul-25, Volume: 51, Issue:7

    Topics: Aspartic Acid; Brain Neoplasms; Humans; Lactates; Magnetic Resonance Spectroscopy

1991
In vivo 1H-spectroscopy of human intracranial tumors at 1.5 tesla. Preliminary experience at a clinical installation.
    Acta radiologica (Stockholm, Sweden : 1987), 1991, Volume: 32, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactate

1991
Noninvasive differentiation of tumors with use of localized H-1 spectroscopy in vivo: initial experience in patients with cerebral tumors.
    Investigative radiology, 1990, Volume: 25, Issue:9

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Diagnosis, Differential; Humans; Lactates; Magnetic Resonance

1990
Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1H NMR spectroscopic imaging.
    Magnetic resonance in medicine, 1990, Volume: 13, Issue:1

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resona

1990
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
    Radiology, 1989, Volume: 172, Issue:2

    Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts;

1989
Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:10

    Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Brain; Brain Neoplasms; Cytarabine; Cytidine Deaminas

1987
Aspartame. Review of safety issues. Council on Scientific Affairs.
    JAMA, 1985, Jul-19, Volume: 254, Issue:3

    Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplas

1985
Some biochemical characteristics of neuroglia as deduced by glial tumor biochemical analysis.
    Journal of neurosurgery, 1971, Volume: 34, Issue:3

    Topics: Aminobutyrates; Aspartic Acid; Astrocytoma; Brain; Brain Chemistry; Brain Neoplasms; Carboxy-Lyases;

1971
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.
    Journal of neurochemistry, 1972, Volume: 19, Issue:2

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Cattle; Cerebral Cortex; Craniopharyngioma; Glioblastoma; G

1972
[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1972, Volume: 115, Issue:1

    Topics: Adenoma; Aspartate Aminotransferases; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Craniopha

1972
Amino acid uptake into human brain tumors.
    Brain research, 1974, Aug-09, Volume: 76, Issue:1

    Topics: Absorption; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Astrocytoma; Autoradiography; Brain

1974
[Various low-molecular nitrogen compounds in experimental brain tumors in white mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1970, Volume: 69, Issue:5

    Topics: Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain; Brain Neoplasms; Glutamates; Mice; Neoplasms

1970