aspartic acid has been researched along with Brain Diseases in 134 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 9.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
| " We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 7.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
| "Cerebral cortex tissue was obtained at autopsy from neonatal Poll Hereford calves with clinically confirmed maple syrup urine disease (MSUD), neonatal Holstein-Friesian calves with clinically confirmed citrullinemia, and matched controls." | 7.68 | Glutamate and gamma-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves. ( Dennis, JA; Dodd, PR; Gundlach, AL; Harper, PA; Healy, PJ; Johnston, GA; Williams, SH, 1992) |
| "Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 5.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| " Urine excretion of N-acetylaspartic acid was grossly increased, suggesting Canavan disease." | 3.81 | Leukodystrophy with multiple beaded periventricular cysts: unusual cranial MRI results in Canavan disease. ( Drenckhahn, A; Knierim, E; Schuelke, M, 2015) |
| "Higher triglyceride and lower HDL levels statistically account for the association between BMI and myo-inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity." | 3.79 | Dyslipidemia links obesity to early cerebral neurochemical alterations. ( Gonzales, MM; Haley, AP; Tanaka, H; Tarumi, T, 2013) |
| " We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 3.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
| "Eight patients with advanced breast cancer were entered into a prospective, longitudinal trial that included examination by MR imaging and proton MR spectroscopy before chemotherapy and through 12 months after treatment with carmustine, cyclophosphamide, and cisplatin, combined with autologous hematopoietic progenitor cell support (AHPCS)." | 3.70 | White matter disease induced by high-dose chemotherapy: longitudinal study with MR imaging and proton spectroscopy. ( Brown, MS; Cagnoni, PJ; Jones, RB; Sheeder, JL; Simon, JH; Stears, JC; Stemmer, SM, 1998) |
| "(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas." | 3.69 | Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995) |
| " All high-grade gliomas (n = 37) showed high choline and low or absent N-acetyl-L-aspartate and creatine along with lipid and/or lactate, whereas low-grade gliomas (n = 23) were characterized by low N-acetyl-aspartate and creatine and high choline and presence of only lactate." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
| "Cerebral cortex tissue was obtained at autopsy from neonatal Poll Hereford calves with clinically confirmed maple syrup urine disease (MSUD), neonatal Holstein-Friesian calves with clinically confirmed citrullinemia, and matched controls." | 3.68 | Glutamate and gamma-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves. ( Dennis, JA; Dodd, PR; Gundlach, AL; Harper, PA; Healy, PJ; Johnston, GA; Williams, SH, 1992) |
| "Ornithine and arginine compounds were highly effective in preventing an increase in blood ammonia and in preventing or minimizing encephalopathy after acute subcoma, coma-inducing, or lethal doses of NH4+." | 3.67 | Ammonia toxicity: comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate, and carbamyl glutamate. ( Lyftogt, C; Raphael, D; Zieve, L, 1986) |
| "Most cases of the narcoleptic syndrome are considered to be idiopathic because no structural lesion is detectable, although some cases of secondary narcolepsy are known to be associated with no structural brainstem lesions." | 2.69 | Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion? ( Ellis, CM; Lemmens, G; Parkes, JD; Simmons, A; Williams, SC, 1998) |
| "Lipopolysaccharide (LPS)-induced encephalopathy induces neuroinflammation." | 1.51 | Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. ( Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA, 2019) |
| "Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare neurodegenerative disorder with various clinical presentations." | 1.46 | MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation. ( Abe, T; Fujita, K; Harada, M; Izumi, Y; Kaji, R; Kawarai, T; Matsuda, T; Matsui, N; Sakai, W; Sako, W; Terasawa, Y; Tsukamoto-Miyashiro, A, 2017) |
| "The histological diagnosis was anaplastic oligodendroglioma (WHO grade III)." | 1.37 | [Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]. ( Akutsu, H; Anno, I; Isobe, T; Masumoto, T; Matsumura, A; Nakai, K; Shiigai, M; Takano, S; Yamamoto, T, 2011) |
| "Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a recently described disorder with autosomal recessive mode of inheritance." | 1.35 | Leukoencephalopathy with brain stem and spinal cord involvement and high lactate: a genetically proven case with distinct MRI findings. ( Baskan, O; Gunal, DI; Isak, B; Koseoglu, M; Ozsahin, S; Scheper, GC; Uluc, K; van der Knaap, MS; Yildirim, KA, 2008) |
| "In contrast, postnatal infections and hypotension are associated with an increased risk of white matter injury in the premature newborn." | 1.35 | Effect of chorioamnionitis on brain development and injury in premature newborns. ( Bowen-Roberts, T; Brant, R; Chau, V; McFadden, DE; Miller, SP; Poskitt, KJ; Sargent, MA; Soulikias, W; Synnes, A, 2009) |
| "Diffuse leukoencephalopathy associated with ocular malformations of the Axenfeld-Rieger type was observed in five individuals." | 1.34 | COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke. ( Arveiler, B; Bouchet, JP; Burgelin, I; Calvas, P; Coupry, I; Dousset, V; Goizet, C; Gorry, P; Lacombe, D; Menegon, P; Orgogozo, JM; Orignac, I; Sibon, I, 2007) |
| "Active demyelination or increased myelin turnover might contribute to the hitherto unexplained WMD of this rare disorder." | 1.33 | White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination. ( Anhuf, D; Häusler, M; Möller-Hartmann, W; Ramaekers, VT; Schüler, H; Thron, A; Zerres, K, 2005) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging." | 1.31 | Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome. ( Barker, PB; Beauchamp, NJ; Eichler, FS; Wang, P; Wityk, RJ, 2002) |
| "Also, patients with Wilson disease and portosystemic shunting had lower myo-inositol-creatine ratios than did patients with Wilson disease and no portosystemic shunting (P < ." | 1.30 | Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy. ( Hoogenraad, TU; Mali, WP; Van Den Heuvel, AG; Van der Grond, J; Van Rooij, LG; Van Wassenaer-van Hall, HN, 1997) |
| "The study included 12 patients with progressive supranuclear palsy, 10 with Parkinson's disease, nine with corticobasal degeneration and 11 age-matched normal control subjects." | 1.30 | Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. ( Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G, 1997) |
| "However, migraine in SLE was not associated with increased disease activity or severity, neuropsychiatric manifestations, or end-organ involvement compared to patients without migraine (p > 0." | 1.30 | Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus. ( Brooks, WM; Rozell, CL; Sibbitt, WL, 1998) |
| "Late juvenile neuronal ceroid lipofuscinosis (NCL) is a lysosomal neurodegenerative disorder caused by the accumulation of lipopigment in neurons." | 1.30 | MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis. ( Grodd, W; Klose, U; Nägele, T; Schwab, A; Seeger, U; Seitz, D, 1998) |
| "Choline levels were unchanged in the lesions." | 1.29 | Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions. ( Barker, PB; Bryan, RN; Conturo, TE; Oppenheimer, SM; Preziosi, TJ; Soher, BJ, 1995) |
| "Four grades of demyelination and three grades of cerebral atrophy were distinguished by magnetic resonance imaging criteria." | 1.28 | 1H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders. ( den Hollander, JA; Luyten, PR; Nauta, JJ; Valk, J; van der Grond, J; van der Knaap, MS, 1992) |
| "This report examines the safety issues related to the nutritive sweetener aspartame, including possible toxic effects of aspartame's component amino acids, aspartic acid and phenylalanine, and its major decomposition products, methanol and diketopiperazine, and the potential synergistic effect of aspartame and dietary carbohydrate on brain neurochemicals." | 1.27 | Aspartame. Review of safety issues. Council on Scientific Affairs. ( , 1985) |
| "Reversible encephalopathy was observed in 6 (7." | 1.26 | Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate. ( Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG, 1982) |
| "Thiamine-deficient encephalopathy in the rat is characterized by ataxic gait, loss of righting reflex and curvature of the spine." | 1.26 | Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. ( Barbeau, A; Butterworth, RF; Hamel, E; Landreville, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (17.16) | 18.7374 |
| 1990's | 40 (29.85) | 18.2507 |
| 2000's | 46 (34.33) | 29.6817 |
| 2010's | 20 (14.93) | 24.3611 |
| 2020's | 5 (3.73) | 2.80 |
| Authors | Studies |
|---|---|
| Mueller, C | 1 |
| Baird, JF | 1 |
| Motl, RW | 1 |
| Chen, H | 1 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Yi, F | 1 |
| Yang, YS | 1 |
| Smucny, J | 1 |
| Zhang, H | 1 |
| Maddock, RJ | 1 |
| van Karnebeek, CDM | 1 |
| Ramos, RJ | 1 |
| Wen, XY | 1 |
| Tarailo-Graovac, M | 1 |
| Gleeson, JG | 1 |
| Skrypnyk, C | 1 |
| Brand-Arzamendi, K | 1 |
| Karbassi, F | 1 |
| Issa, MY | 1 |
| van der Lee, R | 1 |
| Drögemöller, BI | 1 |
| Koster, J | 1 |
| Rousseau, J | 1 |
| Campeau, PM | 1 |
| Wang, Y | 2 |
| Cao, F | 1 |
| Li, M | 1 |
| Ruiter, J | 1 |
| Ciapaite, J | 1 |
| Kluijtmans, LAJ | 1 |
| Willemsen, MAAP | 1 |
| Jans, JJ | 1 |
| Ross, CJ | 1 |
| Wintjes, LT | 1 |
| Rodenburg, RJ | 1 |
| Huigen, MCDG | 1 |
| Jia, Z | 1 |
| Waterham, HR | 1 |
| Wasserman, WW | 1 |
| Wanders, RJA | 1 |
| Verhoeven-Duif, NM | 2 |
| Zaki, MS | 1 |
| Wevers, RA | 1 |
| Vidya Shankar, R | 1 |
| Hu, HH | 1 |
| Bikkamane Jayadev, N | 1 |
| Chang, JC | 1 |
| Kodibagkar, VD | 1 |
| Towner, RA | 1 |
| Saunders, D | 1 |
| Smith, N | 1 |
| Gulej, R | 1 |
| McKenzie, T | 1 |
| Lawrence, B | 1 |
| Morton, KA | 1 |
| Broeks, MH | 1 |
| Shamseldin, HE | 1 |
| Alhashem, A | 1 |
| Hashem, M | 1 |
| Abdulwahab, F | 1 |
| Alshedi, T | 1 |
| Alobaid, I | 1 |
| Zwartkruis, F | 1 |
| Westland, D | 1 |
| Fuchs, S | 1 |
| Jans, JJM | 1 |
| Alkuraya, FS | 1 |
| Wang, AP | 1 |
| Suryavanshi, T | 1 |
| Marcucci, M | 1 |
| Fong, C | 1 |
| Whitton, AC | 1 |
| Reddy, KKV | 1 |
| Shibasaki, J | 1 |
| Niwa, T | 1 |
| Piedvache, A | 1 |
| Tomiyasu, M | 1 |
| Morisaki, N | 1 |
| Fujii, Y | 2 |
| Toyoshima, K | 1 |
| Aida, N | 1 |
| Hübel, N | 1 |
| Hosseini-Zare, MS | 1 |
| Žiburkus, J | 1 |
| Ullah, G | 1 |
| Haley, AP | 1 |
| Gonzales, MM | 1 |
| Tarumi, T | 1 |
| Tanaka, H | 1 |
| Bladowska, J | 1 |
| Zimny, A | 1 |
| Knysz, B | 1 |
| Małyszczak, K | 1 |
| Kołtowska, A | 1 |
| Szewczyk, P | 1 |
| Gąsiorowski, J | 1 |
| Furdal, M | 1 |
| Sąsiadek, MJ | 1 |
| Hansen, MB | 1 |
| Kondziella, D | 1 |
| Danielsen, ER | 1 |
| Larsen, VA | 1 |
| Jansen, EC | 1 |
| Hyldegaard, O | 1 |
| Drenckhahn, A | 1 |
| Schuelke, M | 1 |
| Knierim, E | 1 |
| Chen, WS | 1 |
| Li, JJ | 1 |
| Hong, L | 1 |
| Xing, ZB | 1 |
| Wang, F | 1 |
| Li, CQ | 1 |
| Martinez, MA | 1 |
| Florenzano, NV | 1 |
| Macchia, EA | 1 |
| Abe, T | 1 |
| Kawarai, T | 1 |
| Fujita, K | 1 |
| Sako, W | 1 |
| Terasawa, Y | 1 |
| Matsuda, T | 2 |
| Sakai, W | 1 |
| Tsukamoto-Miyashiro, A | 1 |
| Matsui, N | 1 |
| Izumi, Y | 1 |
| Kaji, R | 1 |
| Harada, M | 1 |
| Uluc, K | 1 |
| Baskan, O | 1 |
| Yildirim, KA | 1 |
| Ozsahin, S | 1 |
| Koseoglu, M | 1 |
| Isak, B | 1 |
| Scheper, GC | 1 |
| Gunal, DI | 1 |
| van der Knaap, MS | 2 |
| Wood, PB | 1 |
| Ledbetter, CR | 1 |
| Glabus, MF | 1 |
| Broadwell, LK | 1 |
| Patterson, JC | 1 |
| Josey, L | 1 |
| Al Sayyari, A | 1 |
| Buckley, R | 1 |
| Coulthard, A | 1 |
| Majós, C | 1 |
| Aguilera, C | 1 |
| Alonso, J | 1 |
| Julià-Sapé, M | 1 |
| Castañer, S | 1 |
| Sánchez, JJ | 1 |
| Samitier, A | 1 |
| León, A | 1 |
| Rovira, A | 1 |
| Arús, C | 1 |
| de Araújo Filho, GM | 1 |
| Lin, K | 1 |
| Lin, J | 1 |
| Peruchi, MM | 1 |
| Caboclo, LO | 1 |
| Guaranha, MS | 1 |
| Guilhoto, LM | 1 |
| Carrete, H | 1 |
| Yacubian, EM | 1 |
| Chau, V | 1 |
| Poskitt, KJ | 1 |
| McFadden, DE | 1 |
| Bowen-Roberts, T | 1 |
| Synnes, A | 1 |
| Brant, R | 1 |
| Sargent, MA | 1 |
| Soulikias, W | 1 |
| Miller, SP | 1 |
| Lin, YW | 1 |
| Yu, CY | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Wu, SB | 1 |
| Zhou, MQ | 1 |
| Zhou, YP | 1 |
| Wang, KM | 1 |
| Wang, YL | 1 |
| Chen, YN | 1 |
| Cao, J | 1 |
| Sohn, SY | 1 |
| Ko, YJ | 1 |
| Hong, JM | 1 |
| Kim, SH | 1 |
| Kim, HS | 1 |
| Kim, JH | 1 |
| Chi, JG | 1 |
| Moon, SY | 1 |
| Girard, N | 1 |
| Backens, M | 1 |
| Haaxma, CA | 1 |
| Crow, YJ | 1 |
| van Steensel, MA | 1 |
| Lammens, MM | 1 |
| Rice, GI | 1 |
| Verbeek, MM | 1 |
| Willemsen, MA | 1 |
| Reith, W | 1 |
| Isobe, T | 1 |
| Akutsu, H | 1 |
| Yamamoto, T | 1 |
| Shiigai, M | 1 |
| Masumoto, T | 1 |
| Nakai, K | 1 |
| Takano, S | 1 |
| Anno, I | 1 |
| Matsumura, A | 1 |
| Jia, Y | 1 |
| Xu, G | 1 |
| Ling, X | 1 |
| Liu, S | 1 |
| Huang, L | 1 |
| Terek, D | 1 |
| Koroglu, O | 1 |
| Yalaz, M | 1 |
| Gokben, S | 1 |
| Calli, C | 2 |
| Coker, M | 1 |
| Kultursay, N | 1 |
| Gelal, F | 1 |
| Apaydín, M | 1 |
| Erdem, G | 1 |
| Eichler, FS | 2 |
| Itoh, R | 1 |
| Barker, PB | 5 |
| Mori, S | 1 |
| Garrett, ES | 1 |
| van Zijl, PC | 2 |
| Moser, HW | 2 |
| Raymond, GV | 1 |
| Melhem, ER | 1 |
| Smith, JK | 1 |
| Londono, A | 1 |
| Castillo, M | 2 |
| Kwock, L | 2 |
| Baslow, MH | 1 |
| Suckow, RF | 1 |
| Gaynor, K | 1 |
| Bhakoo, KK | 1 |
| Marks, N | 1 |
| Saito, M | 2 |
| Duff, K | 1 |
| Matsuoka, Y | 1 |
| Berg, MJ | 1 |
| Firbank, MJ | 1 |
| Minett, T | 1 |
| O'Brien, JT | 1 |
| Tijssen, MA | 1 |
| Brown, P | 1 |
| MacManus, D | 1 |
| McLean, MA | 1 |
| Davie, C | 1 |
| Bachert, P | 1 |
| Schröder, L | 1 |
| Nagae-Poetscher, LM | 1 |
| Bibat, G | 1 |
| Philippart, M | 1 |
| Rosemberg, S | 1 |
| Fatemi, A | 1 |
| Lacerda, MT | 1 |
| Costa, MO | 1 |
| Kok, F | 1 |
| Costa Leite, C | 1 |
| Horská, A | 1 |
| Naidu, S | 1 |
| Castellino, G | 1 |
| Govoni, M | 1 |
| Padovan, M | 1 |
| Colamussi, P | 1 |
| Borrelli, M | 1 |
| Trotta, F | 1 |
| Häusler, M | 1 |
| Anhuf, D | 1 |
| Schüler, H | 1 |
| Ramaekers, VT | 1 |
| Thron, A | 1 |
| Zerres, K | 1 |
| Möller-Hartmann, W | 1 |
| Chang, L | 2 |
| Ernst, T | 2 |
| Speck, O | 1 |
| Grob, CS | 1 |
| Briellmann, RS | 1 |
| Wellard, RM | 1 |
| Jackson, GD | 1 |
| Hall, NJ | 1 |
| Smith, VV | 1 |
| Harding, B | 1 |
| Pierro, A | 1 |
| Eaton, S | 1 |
| De Stefano, N | 2 |
| Bartolozzi, ML | 1 |
| Guidi, L | 1 |
| Stromillo, ML | 1 |
| Federico, A | 1 |
| Groeschel, S | 1 |
| Brockmann, K | 2 |
| Dechent, P | 3 |
| Wilichowski, E | 1 |
| Frahm, J | 4 |
| Hanefeld, F | 2 |
| Koudijs, SM | 1 |
| van der Grond, J | 3 |
| Hoogendoorn, ML | 1 |
| Hulshoff Pol, HE | 1 |
| Schnack, HG | 1 |
| Witkamp, TD | 1 |
| Gooskens, RH | 1 |
| van Nieuwenhuizen, O | 1 |
| Braun, KP | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Porto, L | 1 |
| Hattingen, E | 1 |
| Pilatus, U | 1 |
| Kieslich, M | 1 |
| Yan, B | 1 |
| Schwabe, D | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Mason, GF | 1 |
| Di Costanzo, A | 2 |
| Trojsi, F | 1 |
| Tosetti, M | 2 |
| Schirmer, T | 1 |
| Lechner, SM | 1 |
| Popolizio, T | 2 |
| Scarabino, T | 2 |
| Giannatempo, GM | 1 |
| d'Alesio, V | 1 |
| Esposito, F | 1 |
| Di Salle, F | 1 |
| Bertolino, A | 2 |
| Maggialetti, A | 1 |
| Salvolini, U | 1 |
| Qiu, SJ | 1 |
| Zhang, XL | 1 |
| Zhang, Y | 1 |
| Jiang, M | 1 |
| Taylor, MJ | 1 |
| Schweinsburg, BC | 1 |
| Alhassoon, OM | 1 |
| Gongvatana, A | 1 |
| Brown, GG | 1 |
| Young-Casey, C | 1 |
| Letendre, SL | 1 |
| Grant, I | 1 |
| Sibon, I | 1 |
| Coupry, I | 1 |
| Menegon, P | 1 |
| Bouchet, JP | 1 |
| Gorry, P | 1 |
| Burgelin, I | 1 |
| Calvas, P | 1 |
| Orignac, I | 1 |
| Dousset, V | 1 |
| Lacombe, D | 1 |
| Orgogozo, JM | 1 |
| Arveiler, B | 1 |
| Goizet, C | 1 |
| Kayabas, U | 1 |
| Alkan, A | 2 |
| Firat, AK | 2 |
| Karakas, HM | 1 |
| Bayindir, Y | 1 |
| Yetkin, F | 1 |
| Nitkunan, A | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Barrick, TR | 1 |
| Howe, FA | 2 |
| Markus, HS | 1 |
| Güngör, S | 1 |
| Akinci, A | 1 |
| Tabel, Y | 1 |
| Dreha-Kulaczewski, SF | 1 |
| Finsterbusch, J | 1 |
| Gärtner, J | 1 |
| Hanefeld, FA | 1 |
| Dezortova, M | 1 |
| Hajek, M | 2 |
| Emad, Y | 1 |
| Ragab, Y | 1 |
| Zeinhom, F | 1 |
| El-Khouly, G | 1 |
| Abou-Zeid, A | 1 |
| Rasker, JJ | 1 |
| Wiley, RG | 1 |
| Gralla, RJ | 2 |
| Casper, ES | 2 |
| Kemeny, N | 1 |
| Natale, RB | 1 |
| Yagoda, A | 1 |
| Young, CW | 1 |
| Constans, JM | 1 |
| Meyerhoff, DJ | 1 |
| Gerson, J | 1 |
| MacKay, S | 1 |
| Norman, D | 1 |
| Fein, G | 1 |
| Weiner, MW | 2 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
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| Buchthal, S | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
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| Gupta, RK | 1 |
| Roy, R | 1 |
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| Kimura, H | 2 |
| Itoh, S | 1 |
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| Tedeschi, G | 2 |
| Schiffmann, R | 1 |
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| Sanni, LA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for aspartic acid and Brain Diseases
| Article | Year |
|---|---|
Targeting NMDA receptor signaling for therapeutic intervention in brain disorders.
Topics: Aspartic Acid; Brain; Brain Diseases; Humans; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2023 |
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Schizophr | 2023 |
Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
Topics: Aspartic Acid; Brain Diseases; Carcinoma; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy | 2016 |
[Metabolism of N-acetyl-L-aspartate: its diagnostic and prognostic value].
Topics: Animals; Aspartic Acid; Brain Diseases; Humans; Magnetic Resonance Spectroscopy; Prognosis | 2016 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
[Magnetic resonance spectroscopy for cerebral imaging].
Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea | 2010 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis.
Topics: Aspartic Acid; Axons; Brain Diseases; Creatine; Disability Evaluation; Humans; Magnetic Resonance Im | 2005 |
Proton MR spectroscopy of the brain at 3 T: an update.
Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Cortex; Choline; Creatine | 2007 |
(1)H MR spectroscopy in pediatrics.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Choline; Creatine; G | 2008 |
Neurochemical and biophysical assessment of neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Aspartic Acid; Asphyxia Neonatorum; Brain; Brain Diseases; Brain Ischemia; Electrophysiolog | 1994 |
Role of excitotoxins in developmental neuropathology.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain Diseases; Brain Ischemia; Cloning, Molecu | 1993 |
Introduction to hippocampal spectroscopy.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Hippocampus; Humans; Hydrogen; Image Enhancement; | 1997 |
Proton magnetic resonance spectroscopy for the diagnosis and management of cerebral disorders.
Topics: Aspartic Acid; Brain Diseases; Creatine; Humans; Magnetic Resonance Spectroscopy; Neurons; Protons | 1999 |
Proton MR spectroscopy in clinical routine.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Humans; Lactic Acid; Magnetic Resonance Spectrosco | 2001 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
Cerebral hypoxia: some new approaches and unanswered questions.
Topics: Animals; Aspartic Acid; Brain Diseases; Cell Survival; Cerebrovascular Circulation; Excitatory Amino | 1990 |
[Excitatory amino acid and their involvement in pathological processes in the brain].
Topics: Animals; Aspartic Acid; Brain Diseases; gamma-Aminobutyric Acid; Humans; N-Methylaspartate | 1990 |
Role of endogenous excitatory amino acid neurotransmitters in the pathogenesis and evolution of acute brain injury.
Topics: Acute Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Injuries; Calcium; Calcium | 1989 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor | 1985 |
2 trials available for aspartic acid and Brain Diseases
| Article | Year |
|---|---|
Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Cross-Sectional St | 2003 |
Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion?
Topics: Adolescent; Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Humans; Magnetic Resonance Spect | 1998 |
112 other studies available for aspartic acid and Brain Diseases
| Article | Year |
|---|---|
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
Topics: Alleles; Animals; Aspartic Acid; Brain Diseases; Child; Child, Preschool; Exome Sequencing; Fatty Ac | 2019 |
2-D magnetic resonance spectroscopic imaging of the pediatric brain using compressed sensing.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Co | 2019 |
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex | 2019 |
MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy.
Topics: Age of Onset; Aspartic Acid; Brain Diseases; Child, Preschool; Female; Humans; Malate Dehydrogenase; | 2019 |
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err | 2020 |
Comparison of Predictive Values of Magnetic Resonance Biomarkers Based on Scan Timing in Neonatal Encephalopathy Following Therapeutic Hypothermia.
Topics: Aspartic Acid; Biomarkers; Brain Diseases; Dipeptides; Gray Matter; Humans; Hypothermia, Induced; In | 2021 |
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.
Topics: Animals; Aspartic Acid; Astrocytes; Brain Diseases; Cell Size; Computational Biology; Electrophysiol | 2017 |
Dyslipidemia links obesity to early cerebral neurochemical alterations.
Topics: Adult; Aspartic Acid; Blood Glucose; Blood Pressure; Body Mass Index; Brain; Brain Diseases; Cholest | 2013 |
Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: a pilot study.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Diseases; Case-Control Studies; Cerebrovascular Cir | 2013 |
Cerebral proton magnetic resonance spectroscopy demonstrates reversibility of N-acetylaspartate/creatine in gray matter after delayed encephalopathy due to carbon monoxide intoxication: a case report.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases; Carbon Monoxide Poisoning; Creatine; Female; Humans; Ma | 2014 |
Leukodystrophy with multiple beaded periventricular cysts: unusual cranial MRI results in Canavan disease.
Topics: Amidohydrolases; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Central Nervous System Cysts | 2015 |
MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation.
Topics: Adult; Aged; Aspartic Acid; Brain Diseases; Female; Humans; Leukoencephalopathies; Macrophage Colony | 2017 |
Leukoencephalopathy with brain stem and spinal cord involvement and high lactate: a genetically proven case with distinct MRI findings.
Topics: Adult; Aspartate-tRNA Ligase; Aspartic Acid; Brain Diseases; Brain Stem; Creatine; Humans; Lactic Ac | 2008 |
Hippocampal metabolite abnormalities in fibromyalgia: correlation with clinical features.
Topics: Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Fibromyalgia; Hippocampus; Humans; Magnetic | 2009 |
Usefulness of susceptibility-weighted imaging for voxel placement in MR spectroscopy.
Topics: Artifacts; Aspartic Acid; Brain Diseases; Choline; Creatine; Electromagnetic Fields; Gadolinium; Hum | 2009 |
Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Diagnosis, Differe | 2009 |
Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Frontal Lobe; Glutamic Acid; Glu | 2009 |
Effect of chorioamnionitis on brain development and injury in premature newborns.
Topics: Anisotropy; Aspartic Acid; Brain; Brain Diseases; Choline; Chorioamnionitis; Diffusion Magnetic Reso | 2009 |
Reversible focal splenium lesion--MRS study of a different etiology.
Topics: Adult; Aspartic Acid; Brain Diseases; Brain Mapping; Corpus Callosum; Diffusion Magnetic Resonance I | 2009 |
[Study on the mechanism of electroacupuncture of different acupoint groups in the treatment of cerebrocardiac syndrome in rats].
Topics: Acupuncture Points; Animals; Aspartic Acid; Brain; Brain Diseases; Disease Models, Animal; Electroac | 2009 |
A case of pigmentary orthochromatic leukodystrophy with findings of proton MR spectroscopy and serial brain MRIs.
Topics: Adult; Antigens, CD; Aspartic Acid; Brain; Brain Diseases; Brain Mapping; Creatine; Demyelinating Di | 2010 |
[Basic principles of MR spectroscopy].
Topics: Aspartic Acid; Biomarkers; Brain; Brain Diseases; Creatinine; Humans; Magnetic Resonance Spectroscop | 2010 |
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome.
Topics: Adolescent; Amino Acid Substitution; Asparagine; Aspartic Acid; Brain Diseases; DNA; Exodeoxyribonuc | 2010 |
[Magnetic resonance spectroscopy in the central nervous system].
Topics: Aspartic Acid; Biomarkers; Brain; Brain Diseases; Creatinine; Humans; Magnetic Resonance Spectroscop | 2010 |
[Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma].
Topics: Adult; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; F | 2011 |
Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Choline; Creatine; Depressive Dis | 2012 |
Diagnostic tools of early brain disturbances in an asymptomatic neonate with maple syrup urine disease.
Topics: Aspartic Acid; Brain Diseases; Brain Waves; Consanguinity; Developmental Disabilities; Diet; Diet, C | 2013 |
van der Knaap's leukoencephalopathy: report of five new cases with emphasis on diffusion-weighted MRI findings.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child, Preschool; Choline; Creatine; C | 2002 |
Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experience.
Topics: Adolescent; Adrenoleukodystrophy; Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Chil | 2002 |
Proton magnetic resonance spectroscopy of brain-stem lesions.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neoplasms; Choline; Cr | 2002 |
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Brain Diseases; Cell Survival; Cells, | 2003 |
Magnetic resonance spectroscopy of cerebral cortex is normal in hereditary hyperekplexia due to mutations in the GLRA1 gene.
Topics: Adolescent; Adult; Aspartic Acid; Brain Diseases; Brain Stem; Cerebral Cortex; Female; Frontal Lobe; | 2003 |
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh | 2003 |
Leukoencephalopathy, cerebral calcifications, and cysts: new observations.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; C | 2004 |
Proton magnetic resonance spectroscopy may predict future brain lesions in SLE patients: a functional multi-imaging approach and follow up.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Choline; Creatine; Female; | 2005 |
White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
Topics: Aspartic Acid; Brain Diseases; Choline; Chromosome Deletion; Chromosomes, Human, Pair 18; Demyelinat | 2005 |
Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities.
Topics: Adult; Amphetamine-Related Disorders; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; Choline; | 2005 |
Intestinal ischemia-reperfusion injury does not lead to acute central nervous system damage.
Topics: Acute Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Gangrene; Intestinal Mucosa; Intestine | 2005 |
Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces.
Topics: Aspartic Acid; Brain Diseases; Child; Child, Preschool; Choline; Creatine; Dilatation, Pathologic; D | 2006 |
MRI, volumetry, 1H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly.
Topics: Aspartic Acid; Blood Flow Velocity; Brain; Brain Diseases; Case-Control Studies; Cerebrovascular Cir | 2006 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop | 2007 |
Get sober; stay sober.
Topics: Alcoholism; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Magnetic Resonance Spec | 2007 |
3.0-T functional brain imaging: a 5-year experience.
Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Arteries; Cerebral Cortex | 2007 |
Proton magnetic resonance spectroscopy for radiation encephalopathy induced by radiotherapy for nasopharyngeal carcinoma.
Topics: Adult; Aged; Aspartic Acid; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Sp | 2007 |
Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; CD4 Lymphocyte Count; Central Nervous Sy | 2007 |
COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke.
Topics: Adult; Anterior Eye Segment; Aspartic Acid; Autoantigens; Brain Diseases; Child; Collagen Type IV; E | 2007 |
Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis.
Topics: Acute Disease; Adolescent; Adult; Aspartic Acid; Brain Diseases; Brucellosis; Case-Control Studies; | 2008 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
Neuroimaging findings in hyperargininemia.
Topics: Arginine; Aspartic Acid; Atrophy; Basal Ganglia Cerebrovascular Disease; Brain Diseases; Cerebellum; | 2008 |
Early reduction of total N-acetyl-aspartate-compounds in patients with classical vanishing white matter disease. A long-term follow-up MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain Diseases; Cerebrum; Child; Child, Preschool; Creatine | 2008 |
Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Female; Fibromyalgia; | 2008 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models | 1982 |
Phase I trial of PALA.
Topics: Antineoplastic Agents; Aspartic Acid; Brain Diseases; Diarrhea; Dose-Response Relationship, Drug; Ga | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy.
Topics: Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Developmental Disabilities; Humans; Infan | 1995 |
Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination.
Topics: Aspartic Acid; Ataxia; Brain; Brain Diseases; Child, Preschool; Choline; Creatine; Female; Gaucher D | 1995 |
Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Basal Ganglia; Brain Diseases; Choline; Creatine; Diagnosis, Di | 1995 |
Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Cerebrovascular Circulation; Cer | 1995 |
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di | 1995 |
Multislice proton magnetic resonance spectroscopic imaging in X-linked adrenoleukodystrophy.
Topics: Adolescent; Adrenoleukodystrophy; Adult; Aged; Aspartic Acid; Brain Diseases; Child; Child, Preschoo | 1994 |
Proton in vivo spectroscopy of patients with hyperphenylalaninaemia.
Topics: Adult; Aspartic Acid; Biopterins; Brain; Brain Chemistry; Brain Diseases; Child; Choline; Creatine; | 1993 |
Protracted clinical course for patients with Canavan disease.
Topics: Adolescent; Amidohydrolases; Aspartic Acid; Brain Diseases; Child; Child, Preschool; Female; Fibrobl | 1993 |
Advances in proton magnetic resonance spectroscopy of the brain. A report on a workshop held in Oxford, England December 16-18, 1992.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Diseases; England; Humans; Hydrogen; Magnet | 1993 |
Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Diseases; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance | 1996 |
Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases; Brain Edema; Choline; Chronic Disease; Creatine; Demyel | 1996 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Brain Injuries; Child; Choline; Discriminant Analy | 1997 |
Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Diagnosis, Differential; Fem | 1997 |
Effect of perinatal asphyxia on systemic and intracerebral pH and glycolysis metabolism in the rat.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Chemistry; Brain Diseases; Corpus Striatum; Female; | 1997 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Ma | 1997 |
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo | 1997 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxy | 1998 |
White matter disease induced by high-dose chemotherapy: longitudinal study with MR imaging and proton spectroscopy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain; Brain Diseases; B | 1998 |
Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients.
Topics: Acceleration; Accidents, Traffic; Adult; Aged; Aspartic Acid; Axons; Brain Concussion; Brain Disease | 1998 |
Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Cohort Studies; Di | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases; Case-Control Studies; Cerebellum; Cerebral Ventricles; Child; | 1998 |
Neurometabolite markers of cerebral injury in the antiphospholipid antibody syndrome of systemic lupus erythematosus.
Topics: Adult; Antiphospholipid Syndrome; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Diseases; Cerebr | 1998 |
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Topics: Acute Disease; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Pre | 1999 |
Combined measurements of hippocampal N-acetyl-aspartate and T2 relaxation time in the evaluation of mesial temporal lobe epilepsy: correlation with clinical severity and memory performances.
Topics: Adult; Aspartic Acid; Brain Diseases; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippo | 1999 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Fem | 2001 |
Effect of acute alcohol on ischemia-induced glutamate release and brain damage.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Ethanol; Frontal Lobe; Glutamic Acid; | 2000 |
1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Carbon Isotopes; Chi | 2001 |
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; | 2001 |
Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
Topics: Adult; Aspartic Acid; Brain Diseases; Choline; Confusion; Creatine; Female; Headache; Humans; Magnet | 2002 |
Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Friedreich Ataxia; gamma-Aminobutyric Ac | 1979 |
Aspartate-taurine imbalance in dominantly inherited olivopontocerebellar atrophy.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Cerebellar Cortex; Cerebellar Diseases; Female | 1977 |
Letter: L-glutamic and L-aspartic acids--a question of hazard?
Topics: Animals; Aspartic Acid; Brain Diseases; Diet; Glutamates; Humans; Hypothalamus; Infant; Sweetening A | 1975 |
Contents of several amino acids in the cerebellum, brain stem and cerebrum of the 'staggerer', 'weaver' and 'nervous' neurologically mutant mice.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Stem; Cerebellum; Disease | 1976 |
Glutamate and gamma-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves.
Topics: Acute-Phase Reaction; Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Cattle; Cattle Disea | 1992 |
1H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Child; Creatine; Demyelinating Diseases; Human | 1992 |
Macrocephaly: an important indication for organic acid analysis.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Aspartic Acid; Brain Diseases; Child; Child, Pres | 1991 |
Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Glutamates; Glutamic Acid; Keto | 1989 |
HA-966 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Corpus Striatum; N-Methylaspartate; Oxadia | 1989 |
Quantitative assessment of neuroprotection against NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dibenzo | 1989 |
Spongy degeneration of the neuraxis (Canavan-van Bogaert disease) and N-acetylaspartic aciduria.
Topics: Aspartic Acid; Biopsy; Brain Diseases; Diagnosis, Differential; Humans; Infant | 1989 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Aspartame. Review of safety issues. Council on Scientific Affairs.
Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplas | 1985 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypo | 1985 |
Endogenous excitotoxins as possible mediators of ischemic and hypoglycemic brain damage.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Corpus Striatum; Gluta | 1986 |
Ammonia toxicity: comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate, and carbamyl glutamate.
Topics: Ammonia; Ammonium Chloride; Animals; Arginine; Aspartic Acid; Benzoates; Brain Diseases; Coma; Dose- | 1986 |
Distribution of neuropeptide Y immunoreactivity in the rat basal ganglia: effects of excitotoxin lesions to caudate-putamen.
Topics: Animals; Aspartic Acid; Basal Ganglia; Brain Diseases; Caudate Nucleus; Male; N-Methylaspartate; Ner | 1986 |
D-aspartate in human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain; Brain Di | 1987 |
Biosynthesis of free amino acids in the brain of Jimpy mice.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Brain Diseases; Carbon Radioisoto | 1974 |
Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy.
Topics: Adipates; Alanine; Amino Acids, Dicarboxylic; Amino Acids, Sulfur; Animals; Animals, Newborn; Aspart | 1974 |
Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation.
Topics: Acetylcholine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain Diseases; Brain Stem; Cats | 1969 |
[Argininosuccinic aciduria disease of the newborn with lethal course].
Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Anticonvulsants; Aspartic Acid; Brain Diseases; Chromat | 1968 |