aspartic acid has been researched along with Benign Neoplasms in 115 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (38.26) | 18.7374 |
1990's | 19 (16.52) | 18.2507 |
2000's | 17 (14.78) | 29.6817 |
2010's | 22 (19.13) | 24.3611 |
2020's | 13 (11.30) | 2.80 |
Authors | Studies |
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Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Barsotti, A; Feng, XJ; Gaffney, J; Kim, JI; Lamarque, C; Liu, KG; Momcilovic, M; Morris, K; Olszewski, K; Patel, JP; Poyurovsky, MV; Rabinowitz, JD; Shackelford, DB; Yu, X | 1 |
Bharti, S; Bhujwalla, Z; Gabrielson, E; Tully, E; Woo, J | 1 |
Chen, W; Deng, X; Hu, H; Li, J; Liu, W; Song, Q; Xing, X; Yang, W; Zhang, Y | 1 |
Brzozowska, E; Deshmukh, S | 1 |
Jayakannan, M; Khuddus, M | 1 |
Allard, B; Allard, D; Bareche, Y; Cousineau, I; Fleury, H; Ma, EH; Stagg, J | 1 |
Chattopadhyay, A; Das, T; Ghosh, P; Sahoo, P | 1 |
Ansara, J; Junqueira, C; Kong, Q; Li, S; Lieberman, J; Liu, X; Meza-Sosa, KF; Mok, TMY; Sengupta, S; Wu, H; Xia, S; Yao, Y; Zhang, Y; Zhang, Z | 1 |
Gubina, N; Leboeuf, D; Piatkov, K; Pyatkov, M | 1 |
Jiao, Y; Li, M; Li, Y; Liang, J; Ma, Y; Wang, X; Zeng, Y; Zhang, Y; Zhu, Q | 1 |
All, A; Duan, R; Jiang, X; Lee, LP; Li, X; Liang, L; Liu, B; Liu, X; Wang, Z; Xing, B; Xu, J; Xu, Y; Zeng, X; Zhang, Z | 1 |
Fu, D; Guo, R; Hou, W; Li, Q; Li, T; Liu, Y; Niu, B; Wang, H; Zhang, J | 1 |
Christofk, HR; Halbrook, CJ; Knott, SRV; Krall, AS; Lyssiotis, CA; Mittelman, SD; Momcilovic, M; Mullen, PJ; Schmid, EW; Shackelford, DB; Surjono, F; Thambundit, A | 1 |
Ding, Q; Han, X; Li, S; Liu, Z; Qi, H; Qiao, X; Song, Y; Zhong, Y; Zhou, G | 1 |
Eoh, H; Gao, SJ; Jung, JU; Lee, JJ; Li, T; Lu, C; Ramos da Silva, S; Zhu, Y | 1 |
Danial, NN; Fu, A | 1 |
Bush, LN; Danai, LV; Diehl, FF; Elmiligy, S; Hosios, AM; Lau, AN; Lewis, CA; Luengo, A; Malstrom, S; Sullivan, LB; Vander Heiden, MG | 1 |
Baudrier, L; Birsoy, K; Fidelin, J; Garcia-Bermudez, J; La, K; Lewis, CA; Molina, H; Papagiannakopoulos, T; Possemato, RL; Snuderl, M; Sviderskiy, VO; Zhu, XG | 1 |
Al-Zoughbi, W; Alkan, HF; Bogner-Strauss, JG; Graier, WF; Hoefler, G; Lau, AN; Lewis, CA; Luengo, A; Madl, T; Madreiter-Sokolowski, CT; Stryeck, S; Thomas, CJ; Vander Heiden, MG; Walter, KE | 1 |
Hay, N; Terry, AR | 1 |
Bian, Y; Hu, Y; Ishimwe, N; Jin, P; Lin, J; Liu, L; Liu, Y; Qian, J; Ren, L; Sha, R; Wen, LP; Yin, S; Zhang, W; Zhang, Y | 1 |
Chen, X; Guo, T; Hu, Y; Li, Y; Li, Z; Liu, Y; Qiu, Y; Song, J; Wang, H; Yang, H | 1 |
Acker, T; Aragonés, J; Böğürcü-Seidel, N; Bouthelier, A; De Bock, K; Elorza, A; Escasany, E; Fendt, SM; Fraga, E; Fuertes, E; Giménez-Bachs, JM; Hernansanz-Agustín, P; Li, QOY; Lorendeau, D; Martínez-Ruiz, A; Meléndez-Rodríguez, F; Mesa-Ciller, C; Ortega Muelas, M; Pérez, B; Rinaldi, G; Roche, O; Salinas-Sánchez, AS; Sánchez Prieto, R; Tello, D; Torres-Capelli, M; Turiel, G; Urrutia, AA | 1 |
Eli, M; Kong, B; Mamtimin, B; Turahun, A; Upur, H | 1 |
Acosta-Yebra, D; Bravo-Oro, A; Grimaldo-Zapata, IP; Reyes-Vaca, G | 1 |
Golzarian, J; Huang, H; Huang, J; Xu, K; Yu, J; Yue, T | 1 |
Adler, L; Agron, S; Brandis, A; Dimmock, D; Erez, A; Helbling, D; Itzkovitz, S; Korman, S; Nagamani, SC; Rabinovich, S; Ruppin, E; Sarver, A; Silberman, A; Stettner, N; Sun, Q; Ulitsky, I; Yizhak, K | 1 |
Allen, EL; Artin, E; Chen, Y; Choe, S; Cianchetta, G; Clasquin, MF; Coco, J; Dorsch, M; Fan, ZP; Huang, L; Jin, S; Mahoney, CE; Murtie, J; Pirman, D; Ren, J; Si, Y; Smolen, GA; Ulanet, DB | 1 |
Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG | 1 |
Agapova, LS; Khromova, NV; Kopnin, BP; Kopnin, PB; Stepanova, EV | 1 |
Chen, S; Lao, T; Liang, D; Meng, M; Sang, N | 1 |
Feng, Z; Geng, X; Huang, J; Li, W; Wu, Y; Wu, Z; Xue, X | 1 |
Beglinger, LJ; Capizzano, AA; Gingrich, R; Magnotta, VA; Mills, JA; Vik, SM; Weckmann, MT; Yager, JR | 1 |
Alberton, M; Briel, M; Druyts, E; Mills, EJ; Wu, P | 1 |
Agarwal, MK; Agarwal, ML; Gupta, K; Ruhul Amin, AR; Shin, DM; Thakur, VS; Wald, DN | 1 |
Dewhirst, M; Huang, C; Li, C; Liu, F; Neill, D; Ouyang, R; Yan, B | 1 |
Li, C; Thompson, CB | 1 |
Ando, M; Hanioka, N; Jinno, H; Kaniwa, N; Minami, H; Ohtsu, A; Ozawa, S; Saeki, M; Sai, K; Saijo, N; Saito, Y; Sawada, J; Shirao, K; Tanaka-Kagawa, T; Yoshida, T | 1 |
Bivén, K; Erdal, H; Hägg, M; Linder, S; Lynch, M; Rowley, B; Shoshan, MC; Toi, M; Ueno, T; Wood, J; Zhang, C; Zhou, R | 1 |
IZAKI, K; MIZUSHIMA, S; SAKAGUCHI, KI; TAKAHASHI, H | 1 |
REITH, WS | 1 |
FLIPPIN, RS; MICKELSON, MN | 1 |
FUJII, K; IMADA, R; MATSUURA, K | 1 |
MCCOY, TA; ORR, GR; PATTERSON, MK | 1 |
GENTY, N; MELONI, GA; VENDRELY, R | 1 |
LORINCZ, AB; RYAN, WL | 1 |
CAMBRIA, A; GIUFFRIDA, AM; LOMBARDO, N | 1 |
BENNETT, LL; SMITHERS, D; WARD, CT | 1 |
ANDERSON, EP; MANDEL, HG; SMITH, PK; YEN, CY | 1 |
NIEPER, H | 1 |
ABOOBAKER, VS; APTE, BK; JAYARAMAN, R; SAHASRABUDHE, MB | 1 |
Fujii, Y; Fujimoto, Z; Horii, K; Mizuno, H; Morita, T; Okuda, D | 1 |
Aida, T; Harada, A; Jiang, DL; Kataoka, K; Koyama, H; Nishiyama, N; Zhang, GD | 1 |
NICKELL, LG | 1 |
GREENBERG, DM; KIT, S | 1 |
Briehl, MM; Lutz, NW; Tome, ME | 1 |
Barbet, J; Chatelet, F; Fournié-Zaluski, MC; Gruaz-Guyon, A; Pélaprat, D; Pèlegrin, A; Raguin, O; Romieu, A; Roques, BP | 1 |
Brownlow, N; Dibb, NJ; Domin, J; Taylor, JR | 1 |
Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N | 1 |
Lavasanifar, A; Mahmud, A; Uludağ, H; Xiong, XB | 1 |
Hanaoka, K; Imai, Y; Kaneko, E; Kataoka, K; Kikuchi, K; Kumagai, M; Nagano, T; Nakamura, T; Sekino, M; Shimokado, K; Ueno, S; Yamasaki, Y | 1 |
Beaudoin, B; Bray, K; Chen, G; Degenhardt, K; Jin, S; Karp, CM; Kongara, S; Mathew, R; White, E | 1 |
Albert, PS; Baker, EH; Barnett, AS; Shimoda, KC; Steffen-Smith, EA; Warren, KE; Wolters, PL | 1 |
Coleman, PS; Lavietes, BB | 1 |
Kovacevic, Z; McGivan, JD | 1 |
Pawlicki, M; Zuchowska-Vogelgesang, B | 1 |
Ardalan, B; Jamin, D; Jayaram, HN; Presant, CA | 1 |
Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
Casper, ES; Kemeny, N; Martin, DS; Michaelson, RA; Young, CW | 1 |
Baillon, J; Guichard, M; Hervé, G; Malaise, EP | 1 |
Chabner, BA; Donehower, RC; Erlichman, C; Klecker, R; Speyer, JL | 1 |
Branfman, AR; Bruni, RJ; Chadwick, M; Ervin, TJ; Kufe, DW; Meshad, MW; Schade, D; Weiss, GR | 1 |
Friedman, J; Loo, TL; Marti, JR; Moore, EC; Plunkett, W; Russ, J; Valdivieso, M | 1 |
Appel, H; Lankelma, J; Leyva, A; Pinedo, HM; Smith, P | 1 |
Friedman, J; Loo, TL; Marti, JR; Moore, EC; Stewart, D; Valdivieso, M | 1 |
Branfman, AR; Bruni, RJ; Chadwick, M; Ervin, TJ; Merrill, YN; Strong, JM | 1 |
Casper, ES; Gralla, RJ; Natale, RB; Yagoda, A; Young, CW | 1 |
Busch, H; Henning, D; Le, TV; Valdez, BC | 1 |
Briot, A; Livanos, E; Poulose, B; Roelofs, H; Sage, M; Tlsty, TD; White, A | 1 |
Machover, D | 1 |
Brennan, J; Hageboutros, A; Hudes, GR; LaCreta, FP; McAleer, C; Newman, EM; O'Dwyer, PJ; Ozols, RF; Rogatko, A | 1 |
Briot, A; Hall, I; Jonczyk, P; Livanos, E; Poulose, B; Roelofs, H; Sage, M; Schaefer, D; Tlsty, TD; White, A | 1 |
Bommer, JC; Spikes, JD | 1 |
Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
Brennan, J; Colofiore, J; Green, F; Hageboutros, A; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF | 1 |
Bergljung, C; Bruna, J; Cerwinski, S; Chou, SJ; Fisher, GH; Gruneiro, A; Man, EH; Martin, T; Pappatheodorou, S; Torres, D | 1 |
Capizzi, RL; Case, L; Fernandes, DJ; Fleming, RA; Homesley, H; Loggie, BW; Morris, R; Muss, HB; Richards, F; Russell, GB; Smith, S | 1 |
Brady, F; Brown, G; Harte, RJ; Jones, T; Luthra, SJ; Matthews, JC; O'Reilly, SM; Osman, S; Price, PM; Tilsley, DW | 1 |
Hayashi, T; Kobayashi, M; Kuroki, M; Sakata, I; Tajiri, H | 1 |
Lavelle, F | 1 |
Pham, HT; Ruediger, R; Walter, G | 1 |
Nakajima, T; Tanaka, T | 1 |
Chabner, BA; Cohen, MH; Erlichman, C; Hubbard, SM; Levine, AS; McAvoy, LM; Strong, JM; Wiernik, PH | 1 |
Bowen, JM; Briscoe, WT; Griffin, AC; McBride, C | 1 |
Von Hoff, DD | 1 |
Colofiore, J; Comis, RL; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF; Walczak, J | 1 |
Ardalan, B; Benedetto, P; Feun, L; Livingstone, A; Morrell, L; Reddy, R; Richman, S; Savaraj, N; Stridhar, K; Waldman, S | 1 |
Ardalan, B; Benedetto, P; Feun, L; Fodor, M; Livingstone, A; Morrell, L; Richman, S; Savaraj, N; Sridhar, KS; Waldman, S | 1 |
O'Dwyer, PJ | 1 |
Kemeny, NE; Martin, DS; Schneider, A | 1 |
Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
Chan, TC; Cleary, S; Howell, SB; Markman, M | 2 |
Martin, DS; Sawyer, RC; Stolfi, RL; Young, CW | 1 |
Gottschalk, A; Hoffer, PB | 1 |
Bodansky, O; Nisselbaum, JS; Schwartz, MK | 1 |
Briscoe, WT; Duff, R; Griffin, AC; Rapp, F; Taylor, W | 1 |
Daill, M; Fink, E; Kronberger, L; Schindler, R | 1 |
Freeman, A; Holland, JF; Ohnuma, T; Sinks, LF | 1 |
Chaudhuri, TK; Winchell, HS | 1 |
Schmidt, CG | 1 |
Fink, E; Kronberger, L | 1 |
16 review(s) available for aspartic acid and Benign Neoplasms
Article | Year |
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Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment.
Topics: Antigens, Neoplasm; Arginine; Aspartic Acid; Glycine; Humans; Integrin alphaV; Integrins; Neoplasms; Oligopeptides; Transforming Growth Factor beta | 2022 |
Fuelling cancer cells.
Topics: Asparagine; Aspartic Acid; Disease Progression; Female; Humans; Lactic Acid; Male; Neoplasms; Oxygen Consumption; Proteins; Reference Values; Tumor Cells, Cultured; Tumor Microenvironment | 2019 |
[Reversible cortical atrophy secondary to anti-NMDA receptor antibody encephalitis].
Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Anticonvulsants; Aphasia, Broca; Aspartic Acid; Atrophy; Autoantibodies; Cerebral Arteries; Cerebral Cortex; Child; Delayed Diagnosis; Diagnosis, Differential; Electroencephalography; Epilepsies, Partial; Female; Humans; Learning Disabilities; Magnetic Resonance Imaging; Methylprednisolone; Neoplasms; Prednisone; Sleep Disorders, Circadian Rhythm | 2015 |
Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis.
Topics: Adult; Aged; Alanine Transaminase; Aspartic Acid; Cardiovascular Diseases; Creatinine; Diabetes Mellitus; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Neoplasms; Randomized Controlled Trials as Topic; Rhabdomyolysis | 2012 |
Talaporfin: LS 11, LS11, ME 2906, mono-L-aspartyl chlorin e6, NP e6, NPE 6, taporfin sodium.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chemistry, Pharmaceutical; Chlorophyllides; Clinical Trials as Topic; Drugs, Investigational; Humans; Neoplasms; Photosensitizing Agents; Porphyrins; Radiation-Sensitizing Agents | 2003 |
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Membrane Permeability; Cholesterol; Citric Acid Cycle; Electron Spin Resonance Spectroscopy; Glucose; Glutamates; Glutamic Acid; Glutamine; Lipid Bilayers; Liver Neoplasms, Experimental; Membrane Lipids; Mitochondria; Mitochondria, Liver; Models, Biological; Neoplasms; Oxygen Consumption; Phenotype; Purines; Pyrimidines; Pyruvates; Pyruvic Acid; Surface Properties | 1981 |
Mitochondrial metabolism of glutamine and glutamate and its physiological significance.
Topics: Acidosis; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Cells, Cultured; Energy Metabolism; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Intestine, Small; Intracellular Membranes; Kidney; Liver; Mitochondria; Mitochondria, Liver; Muscles; Neoplasms; Organ Specificity; Oxidation-Reduction; Rats | 1983 |
[New antineoplastic agents, their value and use].
Topics: Aminacrine; Antineoplastic Agents; Aspartic Acid; Cisplatin; Etoposide; Humans; Ifosfamide; Interferons; Medroxyprogesterone; Medroxyprogesterone Acetate; Methyltestosterone; Neoplasms; Phosphonoacetic Acid; Razoxane; Tamoxifen; Teniposide; Vinca Alkaloids | 1982 |
Genomic integrity and the genetics of cancer.
Topics: Adenovirus E1A Proteins; Adenoviruses, Human; Antimetabolites; Apoptosis; Aspartic Acid; Cell Cycle; Cells, Cultured; Drug Resistance; Genes, p53; Genome, Human; Germ-Line Mutation; Humans; Li-Fraumeni Syndrome; Neoplasms; Papillomaviridae; Phosphonoacetic Acid | 1994 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
New mechanisms of gene amplification in drug resistance (the episome model).
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); CHO Cells; Cricetinae; Dihydroorotase; DNA, Circular; DNA, Neoplasm; Drug Resistance; Electrophoresis, Gel, Pulsed-Field; Extrachromosomal Inheritance; Gene Amplification; Gene Expression Regulation, Neoplastic; Membrane Glycoproteins; Multienzyme Complexes; Neoplasms; Oncogenes; Phosphonoacetic Acid; Plasmids | 1991 |
The role of low-dose PALA in biochemical modulation.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Neoplasms; Neoplasms, Experimental; Phosphonoacetic Acid; Pyrimidines | 1990 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine | 1987 |
Application of biochemical modulation with a therapeutically inactive modulating agent in clinical trials of cancer chemotherapy.
Topics: Animals; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid | 1985 |
Tumor scanning agents.
Topics: Antibodies, Neoplasm; Aspartic Acid; Bismuth; Bleomycin; Carbon Radioisotopes; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; Cobalt Radioisotopes; Gallium; Hodgkin Disease; Humans; Indium; Iodine Radioisotopes; Liver Neoplasms; Lymphoma; Mediastinal Neoplasms; Melanoma; Methionine; Neoplasms; Radionuclide Imaging; Selenium; Serum Albumin; Tonsillar Neoplasms | 1974 |
Isozymes of aspartate aminotransferase in tissues and blood of man.
Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; Beta-Globulins; Cattle; Choriocarcinoma; Cytoplasm; Dogs; Electrophoresis; Erythrocytes; Female; gamma-Globulins; Gluconeogenesis; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunochemistry; In Vitro Techniques; Isoenzymes; Ketoglutaric Acids; Kinetics; Liver; Methotrexate; Mitochondria; Myocardium; Neoplasms; Organ Specificity; Phenylhydrazines; Pregnancy; Rabbits; Rats; Reticulocytes; Starch | 1966 |
8 trial(s) available for aspartic acid and Benign Neoplasms
Article | Year |
---|---|
Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Child; Child, Preschool; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Neoplasms; Neuropsychological Tests; Neurotoxicity Syndromes; Protons | 2008 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
Phase I study of phosphonacetyl-L-aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Digestive System; Drug Synergism; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Neutropenia; Phosphonoacetic Acid; Proportional Hazards Models; Pyrimidines; Remission Induction; Risk Factors; Thymidylate Synthase | 1995 |
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; RNA, Neoplasm; Thioinosine; Thionucleotides | 1996 |
Phase I study of N-(phosphonacetyl)-L-aspartate with fluorouracil and with or without dipyridamole in patients with advanced cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Dipyridamole; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leukocytes; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine Triphosphate | 1996 |
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine riboside: optimization of 6-methylmercaptopurine riboside dose and schedule through biochemical analysis of sequential tumor biopsy specimens.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1991 |
A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Breast Neoplasms; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Prognosis | 1991 |
Application of biochemical modulation with a therapeutically inactive modulating agent in clinical trials of cancer chemotherapy.
Topics: Animals; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid | 1985 |
93 other study(ies) available for aspartic acid and Benign Neoplasms
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.
Topics: Aspartic Acid; Citric Acid Cycle; Glucose; Humans; Mitochondria; Neoplasms | 2022 |
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells.
Topics: Antineoplastic Agents; Aspartic Acid; Cisplatin; Metformin; NAD; Neoplasms; Pharmaceutical Preparations | 2021 |
Platinum-based nanocomposites loaded with MTH1 inhibitor amplify oxidative damage for cancer therapy.
Topics: Arginine; Aspartic Acid; Catalase; Cell Line, Tumor; Glycine; Humans; Hydrogen Peroxide; Liposomes; Metal Nanoparticles; Nanocomposites; Nanoparticles; Neoplasms; Nucleotides; Oligopeptides; Oxidative Stress; Oxygen; Photochemotherapy; Photosensitizing Agents; Platinum; Reactive Oxygen Species; Silicon Dioxide; Singlet Oxygen | 2022 |
Melt Polycondensation Strategy for Amide-Functionalized l-Aspartic Acid Amphiphilic Polyester Nano-assemblies and Enzyme-Responsive Drug Delivery in Cancer Cells.
Topics: Amides; Animals; Antineoplastic Agents; Aspartic Acid; Doxorubicin; Drug Carriers; Drug Liberation; Fibroblasts; HeLa Cells; Horses; Humans; Mice; Nanoparticles; Neoplasms; Polyesters; Polymers | 2023 |
The CD73 immune checkpoint promotes tumor cell metabolic fitness.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Humans; Mice; Neoplasms | 2023 |
Differential detection of aspartic acid in MCF-7 breast cancer cells.
Topics: Amino Acids; Animals; Aspartic Acid; Humans; Mammals; MCF-7 Cells; Neoplasms | 2023 |
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Topics: Animals; Apoptosis; Aspartic Acid; Cell Line, Tumor; Female; Granzymes; Humans; Loss of Function Mutation; Mice; Neoplasms; Pyroptosis; Receptors, Estrogen; T-Lymphocytes, Cytotoxic | 2020 |
Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets.
Topics: Animals; Apoptosis; Aspartic Acid; Caspases; Conserved Sequence; Humans; Hydrophobic and Hydrophilic Interactions; Neoplasms; Protein Structure, Secondary; Proteolysis; Proteome; Vertebrates | 2020 |
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Topics: Animals; Aspartic Acid; CDC2 Protein Kinase; Citric Acid Cycle; CRISPR-Cas Systems; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Synergism; Fatty Acids; Gene Knockdown Techniques; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; MCF-7 Cells; Metformin; Mice; Neoplasms; Protein Kinase Inhibitors; TOR Serine-Threonine Kinases | 2020 |
Uncovering the Metabolic Origin of Aspartate for Tumor Growth Using an Integrated Molecular Deactivator.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Proliferation; Glucose; Humans; Neoplasms; Tumor Microenvironment | 2021 |
Poly(aspartic acid)-based pH-responsive targeting co-delivery nanoparticles.
Topics: Aspartic Acid; Curcumin; Doxorubicin; Drug Delivery Systems; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Nanoparticles; Neoplasms; Particle Size; Peptides; Tumor Microenvironment | 2021 |
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Topics: Activating Transcription Factor 4; Animals; Asparagine; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Diet; Electron Transport Chain Complex Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred NOD; Mitochondria; Neoplasms; Nucleotides; Survival Rate | 2021 |
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Molecular Docking Simulation; Neoplasms; Phenylalanine; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2017 |
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides | 2017 |
Grasping for aspartate in tumour metabolism.
Topics: Aspartic Acid; Humans; Neoplasms | 2018 |
Aspartate is an endogenous metabolic limitation for tumour growth.
Topics: Animals; Antineoplastic Agents; Asparaginase; Aspartic Acid; Cell Proliferation; Drug Resistance, Neoplasm; Energy Metabolism; Guinea Pigs; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Male; Metabolomics; Metformin; Mice, Nude; Mice, Transgenic; Neoplasms; Signal Transduction; Time Factors; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Aspartic Acid; Biological Transport; Cell Line, Tumor; Cell Proliferation; Electron Transport Chain Complex Proteins; Energy Metabolism; Excitatory Amino Acid Transporter 1; Humans; Metabolomics; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mitochondria; Neoplasms; Signal Transduction; Time Factors; Tumor Burden; Tumor Hypoxia; Tumor Microenvironment; Xenograft Model Antitumor Assays; Young Adult | 2018 |
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Cell Line; Cell Proliferation; Cell Survival; Citric Acid Cycle; Cytosol; Female; Glutamine; Humans; Mice, Inbred C57BL; Mitochondria; Neoplasms | 2018 |
Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Bacteriophage M13; Biological Transport; Cell Surface Display Techniques; Doxorubicin; Ferritins; Glycine; Humans; Nanoparticles; Neoplasms; Peptide Library; Peptides | 2019 |
A Highly Effective π-π Stacking Strategy To Modify Black Phosphorus with Aromatic Molecules for Cancer Theranostics.
Topics: Arginine; Aspartic Acid; Glycine; Humans; Nanocomposites; Neoplasms; Peptides; Phosphorus; Phototherapy; Theranostic Nanomedicine | 2019 |
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Topics: Adult; Aged; Aged, 80 and over; Aspartate Aminotransferase, Cytoplasmic; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Male; Middle Aged; Mitochondrial Proteins; Neoplasms; Oxidation-Reduction; Tumor Suppressor Proteins; Von Hippel-Lindau Tumor Suppressor Protein | 2019 |
[Plasma amino acid profiling of "same symptom for different disease" in Uyghur medicine based on high-performance liquid chromatography].
Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography, High Pressure Liquid; Cystine; Humans; Isoleucine; Leucine; Medicine, Chinese Traditional; Neoplasms; Serine; Tyrosine; Valine | 2014 |
Fabrication and evaluation of tumor-targeted positive MRI contrast agent based on ultrasmall MnO nanoparticles.
Topics: Animals; Aspartic Acid; Biopolymers; Cell Line, Tumor; Cell Survival; Contrast Media; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manganese Compounds; Mice, Nude; Microscopy, Electron, Transmission; Models, Chemical; Molecular Structure; Nanoparticles; Neoplasms; Oxides; Particle Size; Peptides, Cyclic; Polyethylene Glycols; Radiography; Tissue Distribution; Transplantation, Heterologous | 2015 |
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
Topics: Animals; Argininosuccinate Synthase; Aspartate Carbamoyltransferase; Aspartic Acid; Calcium-Binding Proteins; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line, Tumor; Cell Proliferation; Citrullinemia; Cytosol; Dihydroorotase; Down-Regulation; Enzyme Activation; Humans; Male; Mice; Mice, SCID; Neoplasms; Organic Anion Transporters; Phosphorylation; Pyrimidines; TOR Serine-Threonine Kinases | 2015 |
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Respiration; Citric Acid Cycle; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Ketoglutarate Dehydrogenase Complex; Neoplasms; RNA, Small Interfering | 2016 |
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeostasis; Humans; Metformin; Mice, Nude; Mitochondria; NAD; Neoplasms; Pyruvic Acid; Tumor Microenvironment | 2016 |
p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway.
Topics: Aspartic Acid; Genes, p53; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2009 |
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells.
Topics: Alanine; Ammonia; Aspartic Acid; Carbon; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Glucose; Glutamine; Humans; Ketoglutaric Acids; Metabolism; Mitochondria; Neoplasms; Nitrogen; Nucleic Acids; Stress, Physiological | 2010 |
A novel GAP460 biopolymer for use as a carrier in drug-delivery applications.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Cisplatin; Drug Carriers; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Polyglutamic Acid; Toxicity Tests | 2011 |
Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium.
Topics: Adult; Aged; Aspartic Acid; Bone Marrow Transplantation; Choline; Delirium; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Protons; Retrospective Studies; Spectrum Analysis | 2011 |
N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Bcl-2-Like Protein 11; Cells, Cultured; DNA-Binding Proteins; Drug Evaluation, Preclinical; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Neoplasms; Nuclear Proteins; Phosphonoacetic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation | 2013 |
Heat induces gene amplification in cancer cells.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Aspartate Carbamoyltransferase; Aspartic Acid; Dihydroorotase; DNA Breaks, Double-Stranded; Gene Amplification; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hot Temperature; Humans; Hyperthermia, Induced; Neoplasms; Phosphonoacetic Acid | 2012 |
Cancer. DNA damage, deamidation, and death.
Topics: Antineoplastic Agents; Apoptosis; Asparagine; Aspartic Acid; bcl-X Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA, Neoplasm; Genes, p53; Genes, Retinoblastoma; Humans; Models, Biological; Mutation; Neoplasms; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2002 |
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Camptothecin; COS Cells; Exons; Genetic Variation; Glucuronates; Glucuronic Acid; Glucuronosyltransferase; Humans; Irinotecan; Japan; Mutation; Neoplasms; Polymorphism, Single Nucleotide; Transfection; UDP-Glucuronosyltransferase 1A9 | 2003 |
A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Aspartic Acid; Caspases; Cell Line, Tumor; Cytochromes c; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Keratins; Membrane Potentials; Mitochondria; Neoplasm Recurrence, Local; Neoplasms; Peptide Fragments; Predictive Value of Tests; Reproducibility of Results; Treatment Outcome | 2003 |
The determination of D-glutamic and D-aspartic acids content of malignant tumors and normal tissues by means of new oxidase.
Topics: Aspartic Acid; D-Aspartic Acid; Glutamates; Humans; Neoplasms; Oxidoreductases | 1956 |
Incorporation of radioactive aspartic acid into the proteins and related fractions in mice bearing the Ehrlich ascites carcinoma.
Topics: Animals; Ascites; Aspartic Acid; Carcinoma; Mice; Neoplasms; Proteins; Radioactivity | 1956 |
Effects of certain amino acid derivatives on microorganisms and sarcoma 180.
Topics: Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Lactobacillus; Neoplasms; Sarcoma 180 | 1958 |
[L-ASPARTIC ACID K,MG SALTS FOR RADIATION SICKNESS].
Topics: Animals; Aspartic Acid; Female; Japan; Lung Neoplasms; Magnesium; Mice; Neoplasms; Potassium; Radiation Injuries; Research; Salts; Statistics as Topic; Uterine Neoplasms | 1963 |
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; Malates; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Proteins; Research; Sarcoma; Sarcoma, Experimental | 1963 |
[CONTRIBUTION TO THE STUDY OF RIBONUCLEOPROTEINS OF NORMAL AND NEOPLASTIC TISSUES].
Topics: Alanine; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Glycine; Isoleucine; Leucine; Liver; Lysine; Mice; Neoplasm Proteins; Neoplasms; Nucleoproteins; Phenylalanine; Rats; Research; Ribonucleoproteins; RNA; RNA, Neoplasm; Serine; Threonine; Tyrosine; Valine | 1963 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
[INCORPORATION OF FORMATE-C14 IN THE BASES OF THE NUCLEIC ACIDS OF STICKER'S TUMOR IN VIVO AND IN VITRO].
Topics: Adenine; Aspartic Acid; Carbon Isotopes; DNA; DNA, Neoplasm; Dogs; Formates; Glucose; Glutamine; In Vitro Techniques; Metabolism; Neoplasms; Neoplasms, Experimental; Nucleic Acids; Pharmacology; Research; RNA; RNA, Neoplasm; Thymine | 1963 |
INHIBITION OF DNA SYNTHESIS IN MAMMALIAN CELLS BY ACTIDIONE.
Topics: Adenine; Adenine Nucleotides; Anti-Bacterial Agents; Aspartic Acid; Carbon Isotopes; Carcinoma, Squamous Cell; Cycloheximide; Cytosine Nucleotides; DNA; DNA Replication; DNA, Neoplasm; Formates; Glycine; Guanine Nucleotides; Leucine; Metabolism; Neoplasms; Nucleosides; Nucleotides; Nucleotidyltransferases; Orotic Acid; Pharmacology; Research; RNA; RNA, Neoplasm; Thymidine; Tissue Culture Techniques; Tritium | 1964 |
Ureidosuccinic acid as a precursor of nucleic acid pyrimidines in normal and tumor-bearing mice.
Topics: Animals; Aspartic Acid; Mice; Neoplasms; Nucleic Acids; Pyrimidines | 1955 |
[Bases of experimentation and clinical applications of ion transporting agents. The normalizing action of the aspartates of K and Mg on the level of atypical substrates observed in cancer patients, and its significance in the problem of the condition of t
Topics: Aspartic Acid; Ion Transport; Magnesium; Neoplasms; Nutrition Therapy; Potassium; Research Design | 1961 |
Partial deletion of aspartic acid from DNA-proteins during butter yellow carcinogenesis.
Topics: Aspartic Acid; Carcinogenesis; Carcinogens; DNA; Liver; Liver Neoplasms; Neoplasms; Nucleoproteins; p-Dimethylaminoazobenzene | 1962 |
Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD.
Topics: Amino Acid Motifs; Amino Acid Sequence; Angiogenesis Inhibitors; Antineoplastic Agents; Asparagine; Aspartic Acid; Blood Platelets; Cell Adhesion; Crystallography, X-Ray; Disintegrins; Integrin alphaVbeta3; Integrins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Neoplasms; Oligopeptides; Platelet Aggregation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Snake Venoms; Tryptophan | 2003 |
Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer.
Topics: Animals; Aspartic Acid; Carcinoma, Lewis Lung; Drug Carriers; Forecasting; Macromolecular Substances; Metalloporphyrins; Micelles; Nanotechnology; Neoplasms; Phenyl Ethers; Photochemotherapy; Photosensitizing Agents; Phototherapy; Polyethylene Glycols; Polymers; Porphyrins; Proteins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2003 |
Effect of aspartic acid on growth of plant-virus tumour tissue.
Topics: Aspartic Acid; Neoplasms; Physiological Phenomena | 1950 |
Tracer studies on the metabolism of the Gardner lymphosarcoma. IV. The conversion of lactate-2-C14 to alanine, glutamate, and aspartate by tumor and spleen cells.
Topics: Alanine; Aspartic Acid; Glutamates; Glutamic Acid; Lactic Acid; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Spleen | 1951 |
Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Antioxidants; Aspartic Acid; Cell Line, Tumor; Glycolysis; Glycosylation; Hexokinase; Mice; Neoplasms; Taurine | 2005 |
A labeled neutral endopeptidase inhibitor as a potential tool for tumor diagnosis and prognosis.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cell Line, Tumor; Humans; Mice; Mice, Inbred BALB C; Models, Biological; Molecular Structure; Neoplasms; Neprilysin; Phosphinic Acids; Prognosis; Protease Inhibitors | 2005 |
FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Benzamides; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Inflammation; Inhibitory Concentration 50; Macrophage Colony-Stimulating Factor; Mice; Mutation; Neoplasms; Oncogene Protein v-cbl; Phosphorylation; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-kit; Pyrimidines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; Time Factors; Valine | 2006 |
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Glioblastoma; Glioma; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Neoplasms; Phosphocreatine; Spectrophotometry | 2005 |
Conjugation of arginine-glycine-aspartic acid peptides to poly(ethylene oxide)-b-poly(epsilon-caprolactone) micelles for enhanced intracellular drug delivery to metastatic tumor cells.
Topics: Aldehydes; Arginine; Aspartic Acid; Cell Line, Tumor; Drug Delivery Systems; Glycine; Humans; Lactones; Micelles; Microscopy, Confocal; Microscopy, Fluorescence; Models, Chemical; Neoplasm Metastasis; Neoplasms; Peptides; Polyethylene Glycols | 2007 |
Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging.
Topics: Animals; Aspartic Acid; Coated Materials, Biocompatible; Colonic Neoplasms; Contrast Media; Female; Hydrogen-Ion Concentration; Hydroxides; Iron; Magnetic Resonance Imaging; Mice; Mice, Inbred Strains; Nanoparticles; Neoplasm Transplantation; Neoplasms; Particle Size; Polyethylene Glycols; Polymers; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2007 |
Autophagy suppresses tumor progression by limiting chromosomal instability.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Autophagy; Autophagy-Related Protein 5; Beclin-1; Blotting, Western; Cells, Cultured; Centrosome; Chromosomal Instability; Chromosome Aberrations; Disease Progression; DNA Damage; Epithelial Cells; Fluorescent Antibody Technique; Kidney; Loss of Heterozygosity; Metabolism; Mice; Mice, Knockout; Microtubule-Associated Proteins; Neoplasms; Phosphonoacetic Acid; Ploidies; Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Signal Transduction | 2007 |
Phase I study of continuous-infusion PALA and 5-FU.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Drug Eruptions; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid | 1984 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Phase I evaluation of a biochemically designed combination: PALA, thymidine, and 5-FU.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Fluorouracil; Humans; Neoplasms; Nervous System; Phosphonoacetic Acid; Thymidine | 1984 |
Kinetic parameters of aspartate transcarbamylase in human normal and tumoral cell lines.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Cell Count; Cell Extracts; Cell Line; Cell-Free System; Humans; Kinetics; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Time Factors | 1983 |
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Melanoma; Middle Aged; Neoplasms; Organophosphorus Compounds; Ovarian Neoplasms; Pancreatic Neoplasms; Phosphonoacetic Acid; Sarcoma | 1982 |
A phase I trial of combination therapy with continuous-infusion PALA and continuous-infusion 5-FU.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Bone Marrow; Digestive System; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid | 1982 |
Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate.
Topics: Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Drug Evaluation; Humans; Kinetics; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Proteins; Pyrimidine Nucleotides; Uridine Triphosphate | 1982 |
Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Cell Division; Cell Line; Humans; Leukemia; Melanoma; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid | 1981 |
Pharmacological disposition of N-(phosphonacetyl)-L-aspartate in humans.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Creatinine; Drug Evaluation; Humans; Metabolic Clearance Rate; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Tissue Distribution | 1980 |
Quantitation of the antitumor agent N-(phosphonacetyl)-L-aspartic acid in human plasma and urine by gas chromatography-mass spectrometry-selected ion monitoring.
Topics: Antineoplastic Agents; Aspartic Acid; Gas Chromatography-Mass Spectrometry; Humans; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid | 1980 |
Phase I trial of PALA.
Topics: Antineoplastic Agents; Aspartic Acid; Brain Diseases; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Humans; Leukocyte Count; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Platelet Count; Seizures; Skin Diseases | 1980 |
Specific aspartic acid-rich sequences are responsible for silver staining of nucleolar proteins.
Topics: Amino Acid Sequence; Aspartic Acid; Cell Nucleolus; Cloning, Molecular; Diagnosis, Differential; Escherichia coli; Glutathione Transferase; HeLa Cells; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neoplasms; Nuclear Proteins; Nucleolus Organizer Region; Recombinant Fusion Proteins; Sequence Deletion; Silver; Staining and Labeling | 1995 |
Loss of chromosomal integrity in neoplasia.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Chromosome Aberrations; Dihydroorotase; Drug Resistance; Gene Amplification; Humans; Models, Genetic; Multienzyme Complexes; Neoplasms; Oncogenes; Phosphonoacetic Acid; Tumor Cells, Cultured | 1993 |
Photobleaching of mono-L-aspartyl chlorin e6 (NPe6): a candidate sensitizer for the photodynamic therapy of tumors.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Azides; Deuterium; Humans; Mannitol; Metronidazole; Molecular Structure; Neoplasms; Paraquat; Photochemistry; Photochemotherapy; Photosensitizing Agents; Porphyrins; Solvents | 1993 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Presence of D-aspartate and D-glutamate in tumor proteins.
Topics: Aspartic Acid; Glutamic Acid; Humans; Neoplasm Proteins; Neoplasms; Stereoisomerism | 1995 |
Tumor, normal tissue, and plasma pharmacokinetic studies of fluorouracil biomodulation with N-phosphonacetyl-L-aspartate, folinic acid, and interferon alfa.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Area Under Curve; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Regional Blood Flow; Stomach Neoplasms; Tomography, Emission-Computed | 1999 |
Tumor-enhancement effect of a Mn3+ metalloporphyrin derivative (ATN-4T) in magnetic resonance imaging.
Topics: Animals; Aspartic Acid; Carcinoma, Squamous Cell; Contrast Media; Deuteroporphyrins; Image Enhancement; Magnetic Resonance Imaging; Neoplasm Transplantation; Neoplasms; Rabbits | 1999 |
[Telomerases: transformation trial!].
Topics: Alanine; Antineoplastic Agents; Aspartic Acid; Catalytic Domain; Cell Division; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Isoleucine; Neoplasms; RNA; Telomerase; Transformation, Genetic; Tumor Cells, Cultured; Valine | 1999 |
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Breast Neoplasms; Female; Glutamic Acid; Glycine; Humans; Lung Neoplasms; Melanoma; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phosphoprotein Phosphatases; Point Mutation; Protein Binding; Protein Phosphatase 2; Protein Structure, Secondary; Tryptophan | 2001 |
Isolation and identification of urinary beta-aspartyl dipeptides and their concentrations in human urine.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dipeptides; Female; Glutamates; Glycine; Humans; Hydrogen-Ion Concentration; Male; Methionine; Middle Aged; Neoplasms; Parenteral Nutrition, Total; Sex Factors; Threonine; Uremia | 1978 |
Phase I trial of N-(phosphonacetyl)-L-aspartate.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Colonic Neoplasms; Diarrhea; Drug Eruptions; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Remission, Spontaneous; Stomatitis | 1979 |
The distribution and properties of aspartyl transfer RNA in human and animal tumors.
Topics: Adenocarcinoma; Animals; Aspartic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Female; Genetic Code; Humans; Male; Melanoma; Mice; Neoplasms; Neoplasms, Experimental; Rats; Ribosomes; RNA, Neoplasm; RNA, Transfer; Sarcoma; Simian virus 40 | 1975 |
Phase I study of high dose 5-fluorouracil and high dose Leucovorin with low dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid | 1992 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1985 |
Plasma uridine changes in cancer patients treated with the combination of dipyridamole and N-phosphonacetyl-L-aspartate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyridamole; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1986 |
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyridamole; Drug Evaluation; Drug Synergism; Female; Gastrointestinal Diseases; Headache; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1987 |
Aspartyl transfer RNA profiles in normal and cancer cells.
Topics: Animals; Ascites; Aspartic Acid; Breast Neoplasms; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Cell Transformation, Neoplastic; Chromatography; Chromatography, DEAE-Cellulose; Cricetinae; Humans; Liver; Liver Neoplasms; Methods; Neoplasms; Neoplasms, Experimental; Rats; Rats, Inbred Strains; RNA, Transfer; Simian virus 40; Tritium | 1972 |
[Urinary excretion of asparagne and aspartate in control subjects and patients with cancer before and after treatment with K-Mg-aspartate].
Topics: Adolescent; Adult; Aged; Asparagine; Aspartic Acid; Breast Neoplasms; Cholecystitis; Female; Humans; Magnesium; Male; Middle Aged; Neoplasms; Potassium; Stomach Neoplasms | 1972 |
Biochemical and pharmacological studies with asparaginase in man.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colonic Neoplasms; Escherichia coli; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Melanoma; Metabolic Clearance Rate; Middle Aged; Multiple Myeloma; Neoplasms; Neuroblastoma; Osteosarcoma | 1970 |
Diminished oxidation of 14C-UL-L-asparagine to 14CO2 in mice and humans with tumors: a possible means for assessing efficacy of therapy?
Topics: Animals; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Humans; Injections, Intravenous; Leukemia, Lymphoid; Male; Mice; Multiple Myeloma; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction | 1970 |
[Stimulation of the growth of neoplasms by administration of aspartic acid].
Topics: Asparaginase; Aspartic Acid; Neoplasms | 1970 |
[Change in the concentration of alpha-ketoglutaric acid in carcinoma patients by potassium-magnessium aspartate. 2].
Topics: Adult; Aged; Aspartic Acid; Female; Humans; Ketoglutaric Acids; Magnesium; Male; Methods; Middle Aged; Neoplasms; Potassium | 1968 |