Compounds > aspartic acid
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aspartic acid and BH4 Deficiency

aspartic acid has been researched along with BH4 Deficiency in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199014 (66.67)18.7374
1990's5 (23.81)18.2507
2000's2 (9.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
TSUKADA, Y2
de Valk, HW; Leenders, KL; Oudkerk, M; Reijngoud, DJ; Sijens, PE; van Spronsen, FJ1
Baker, GL; Blaskovics, ME; Filer, LJ; Koch, R; McDonnell, JE; Stegink, LD1
Baker, GL; Filer, LJ; McDonnell, JE; Stegink, LD2
Baert, AL; Breysem, L; François, B; Jaeken, J; Johannik, K; Marchal, G; Smet, MH; Van Hecke, P; Wilms, G1
Hájek, M; Hejcmanová, L; Prádný, J1
Apold, J; Bruland, O; Eiken, HG; Flatmark, T; Knappskog, PM; Martínez, A1
Hewson, AS; Knappskog, PM; Martinez, A; Parniak, MA; Scriver, CR; Treacy, EP; Waters, PI1
Bonafé, L; Burlina, AB; Burlina, AP; Ferrari, V; Suppiej, A; Zacchello, F1
Bhagavan, NV1
Koch, R1
Bell, EF; Filer, LJ; Krause, WL; Stegink, LD; Tephly, TR; Ziegler, EE1
Filer, LJ; Stegink, LD1
Bell, EF; Brummel, MC; Filer, LJ; Krause, WL; Stegink, LD; Wolf-Novak, LC; Ziegler, EE1
Galewicz, A; Gorska, D; Rodo, M; Zaremba, J1
Jenner, FA1
Barkin, E; Levy, HL1

Trials

2 trial(s) available for aspartic acid and BH4 Deficiency

ArticleYear
Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:10

    Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Beverages; Female; Heterozygote; Humans; Male; Methanol; Phenylalanine; Phenylketonurias

1990
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria.
    The Journal of nutrition, 1987, Volume: 117, Issue:11

    Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Biological Transport; Dipeptides; Female; Glutamates; Glutamic Acid; Glutamine; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias; Tyrosine

1987

Other Studies

19 other study(ies) available for aspartic acid and BH4 Deficiency

ArticleYear
[AMINO ACID METABOLISM IN THE BRAIN AND BEHAVIORAL CHANGES].
    No to shinkei = Brain and nerve, 1964, Volume: 16

    Topics: Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Behavior, Animal; Brain; Carbon Isotopes; Conditioning, Classical; Glutamates; Glutamine; Guinea Pigs; Phenylketonurias; Proteins; Rats; Reflex; Research

1964
[BIOCHEMICAL STUDIES ON EXPERIMENTAL PHENYLKETONURIA].
    No to shinkei = Brain and nerve, 1964, Volume: 16

    Topics: Amino Acids; Animals; Aspartic Acid; Diet; Discrimination Learning; Glutamine; Haplorhini; Phenylalanine; Phenylketonurias; Pyruvates; Rabbits; Rats; Research; Tyrosine

1964
1H MR chemical shift imaging detection of phenylalanine in patients suffering from phenylketonuria (PKU).
    European radiology, 2004, Volume: 14, Issue:10

    Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Cerebral Ventricles; Choline; Creatine; Female; Humans; Hydrogen; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Phenylalanine; Phenylketonurias

2004
Plasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight.
    Toxicology, 1981, Volume: 20, Issue:1

    Topics: Adult; Aspartame; Aspartic Acid; Dipeptides; Female; Heterozygote; Humans; Male; Phenylalanine; Phenylketonurias; Sex Factors; Tyrosine

1981
Effect of an abuse dose of aspartame upon plasma and erythrocyte levels of amino acids in phenylketonuric heterozygous and normal adults.
    The Journal of nutrition, 1980, Volume: 110, Issue:11

    Topics: Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Dose-Response Relationship, Drug; Erythrocytes; Female; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias

1980
Localized brain proton NMR spectroscopy in young adult phenylketonuria patients.
    Magnetic resonance in medicine, 1994, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phenylketonurias

1994
Proton in vivo spectroscopy of patients with hyperphenylalaninaemia.
    Neuropediatrics, 1993, Volume: 24, Issue:2

    Topics: Adult; Aspartic Acid; Biopterins; Brain; Brain Chemistry; Brain Diseases; Child; Choline; Creatine; Demyelinating Diseases; Female; Humans; Magnetic Resonance Imaging; Male; Phenylalanine; Phenylketonurias

1993
PKU mutation (D143G) associated with an apparent high residual enzyme activity: expression of a kinetic variant form of phenylalanine hydroxylase in three different systems.
    Human mutation, 1996, Volume: 8, Issue:3

    Topics: Aspartic Acid; Cell Line; Cloning, Molecular; Escherichia coli; Exons; Genetic Variation; Glycine; Humans; Kidney; Kinetics; Mutagenesis, Site-Directed; Phenylalanine Hydroxylase; Phenylketonurias; Polymerase Chain Reaction; Recombinant Fusion Proteins

1996
Comparative analysis of phenylalanine hydroxylase A104D mutant, associated with variant phenylketonuria, and wild-type enzyme.
    Biochemical Society transactions, 1997, Volume: 25, Issue:2

    Topics: Alanine; Aspartic Acid; Chromatography, Affinity; Chromatography, Gel; Humans; Kinetics; Phenylalanine Hydroxylase; Phenylketonurias; Point Mutation; Recombinant Fusion Proteins

1997
Measurement of neurotransmitter metabolites in the cerebrospinal fluid of phenylketonuric patients under dietary treatment.
    Journal of inherited metabolic disease, 2000, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Child; Dipeptides; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Magnetic Resonance Imaging; Male; Phenylketonurias; Radiography; Serotonin

2000
Effect of aspartame loading upon plasma and erythrocyte amino acid levels in phenylketonuric heterozygotes and normal adult subjects.
    The Journal of nutrition, 1979, Volume: 109, Issue:4

    Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Erythrocytes; Female; Heterozygote; Humans; Male; Phenylalanine; Phenylketonurias

1979
Letter: Hazards in indiscriminate use of sweeteners containing phenylalanine.
    The New England journal of medicine, 1975, Jan-02, Volume: 292, Issue:1

    Topics: Aspartic Acid; Diet; Dipeptides; Female; Fetus; Heterozygote; Homozygote; Humans; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Sweetening Agents

1975
Letter: Safety of aspartame as a sweetener.
    The New England journal of medicine, 1975, Mar-13, Volume: 292, Issue:11

    Topics: Aspartic Acid; Dipeptides; Female; Humans; Phenylalanine; Phenylketonurias; Pregnancy; Sweetening Agents

1975
Synthetic sweetners: cyclamates, saccharin, aspartame.
    The Medical letter on drugs and therapeutics, 1975, Jul-18, Volume: 17, Issue:15

    Topics: Animals; Aspartame; Aspartic Acid; Beverages; Cyclamates; Cyclohexylamines; Diet, Reducing; Dipeptides; Female; Fetus; Food; Humans; Maternal-Fetal Exchange; Mice; Phenylketonurias; Piperazines; Placenta; Polyps; Pregnancy; Primates; Rats; Saccharin; United States; United States Food and Drug Administration; Urinary Bladder Neoplasms; Uterine Neoplasms

1975
Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects.
    Diabetes care, 1989, Volume: 12, Issue:1

    Topics: Adult; Aspartame; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Erythrocytes; Female; Glucagon; Heterozygote; Humans; Insulin; Lipids; Male; Methanol; Phenylalanine; Phenylketonurias; Reference Values

1989
Aspartame. Review of safety issues. Council on Scientific Affairs.
    JAMA, 1985, Jul-19, Volume: 254, Issue:3

    Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Carbonated Beverages; Carcinogens; Child; Dietary Carbohydrates; Diketopiperazines; Dipeptides; Drug Stability; Endocrine System Diseases; Female; Glutamates; Glutamic Acid; Humans; Infant; Intellectual Disability; Methanol; Mice; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Piperazines; Pregnancy; Rats

1985
A search for aspartylglycosaminuria in Poland.
    Journal of mental deficiency research, 1974, Volume: 18, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Child, Institutionalized; Chromatography, Paper; Glycosuria; Humans; Intellectual Disability; Phenylketonurias; Poland

1974
Medical research council unit for metabolic studies in psychiatry, Sheffield.
    Psychological medicine, 1973, Volume: 3, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Bipolar Disorder; Catatonia; Circadian Rhythm; Cysteine; Humans; Intellectual Disability; Lithium; Mass Spectrometry; Mental Disorders; Metabolism, Inborn Errors; Periodicity; Phenylketonurias; Sleep; Vasopressins

1973
Comparison of amino acid concentrations between plasma and erythrocytes. Studies in normal human subjects and those with metabolic disorders.
    The Journal of laboratory and clinical medicine, 1971, Volume: 78, Issue:4

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Aspartic Acid; Biological Transport; Child; Chromatography, Ion Exchange; Cystine; Erythrocytes; Glutamates; Glutathione; Glycine; Histidine; Homocystine; Homocystinuria; Humans; Infant; Maple Syrup Urine Disease; Methionine; Ornithine; Phenylketonurias; Plasma; Renal Tubular Transport, Inborn Errors; Serine; Spectrophotometry; Threonine; Tyrosine

1971