Page last updated: 2024-08-17

aspartic acid and Autoimmune Diabetes

aspartic acid has been researched along with Autoimmune Diabetes in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (9.26)	18.7374
1990's	28 (51.85)	18.2507
2000's	13 (24.07)	29.6817
2010's	6 (11.11)	24.3611
2020's	2 (3.70)	2.80

Authors

Authors	Studies
Alonso, GT; Anderson, AW; Cai, LY; Ghetti, S; Glaser, N; Gwal, K; Jaser, SS; Jones, RS; Jordan, LC; Juvera, J; Kang, H; Landman, BA; Lee, CA; LeStourgeon, LM; Mahon, A; Ozturk, A; Patel, NJ; Pruthi, S; Rewers, A; Rewers, MJ; Taki, I; Tanase, C	1
Crawford, SA; Dang, M; Delong, T; Groegler, J; Haskins, K; Hohenstein, AC; Michel, C; Powell, RL; Reyes, K; Wiles, TA	1
Andersen, CU; Brock, B; Brock, C; Drewes, AM; Frøkjær, JB; Hansen, TM; Jakobsen, PE; Juhl, A; Karmisholt, J; Vorum, H	1
Eberly, LE; Kumar, AF; Mangia, S; Moheet, AA; Roberts, RJ; Seaquist, ER; Tkáč, I	1
Cameron, FJ; Finney, K; Inder, TE; Jennings, J; Koves, I; Mackay, M; Nadebaum, C; Neil, JJ; Northam, EA; Scratch, SE; Wellard, RM	1
Gao, L; Huang, M; Lei, H; Zhang, H	1
Hiraga, K; Ichsan, AM; Ishii, Y; Kato, I; Nakada, S; Okamoto, H; Oya, T; Sasahara, M; Shimada, Y; Suzuki, H; Takasawa, K; Takasawa, S; Tobe, K	1
Buonocore, MH; Caltagirone, RA; Glaser, NS; Kuppermann, N; Wootton-Gorges, SL	1
Choi, IY; Lee, P; Smirnova, IV; Wang, WT; Yeh, HW	1
Feuerbach, S; Fründ, R; Geissler, A; Schölmerich, J; Zietz, B	1
Bierhaus, A; Chavakis, T; Hamann, A; Humpert, PM; Isermann, B; Nawroth, P; Nosikov, VV; Reismann, P; Rudofsky, G; Tafel, J; Witte, S	1
Eisenbarth, GS; Park, MH; Shin, CH; Yang, SW; Yu, J	1
Beck, SR; Bowden, DW; Burdon, KP; Freedman, BI; Langefeld, CD; Liu, Y; Rich, SS; Wagenknecht, LE	1
Akinci, A; Alkan, A; Aslan, M; Baysal, T; Ozcan, C; Sarac, K	1
Caputo, M; Cedola, N; Cerrone, GE; Frechtel, GD; Gonzalez, C; Lopez, AP; Mazza, C; Puchulu, FM; Targovnik, HM	1
Cameron, F; McDonnell, C; Northam, E; Rankins, D; Wellard, RM	1
Kazahari, M; Kikuchi, N; Koike, A; Matsuura, N; Nomoto, K; Ohtsu, S; Takubo, N; Yokota, F	1
Chandler, P; Day, S; Hutchings, PR; Kioussis, D; Lund, T; O'Reilly, L; Ozegbe, P; Picard, J; Quartey-Papafio, R; Simpson, E	1
Dahlquist, G; DeWeese, C; Kockum, I; Landin-Olsson, M; Lernmark, A; Lybrand, TP; Sanjeevi, CB; Stenger, D; Sundkvist, G	1
Chen, KH; Chuang, LM; Hsieh, RP; Hu, CY; Jou, TS; Lee, JS; Lin, BJ; Tai, TY; Tsai, WY; Wu, HP	1
Ishii, M; Kasatani, T; Kasuga, A; Kobayashi, A; Maruyama, T; Ozawa, Y; Shimada, A; Suzuki, Y; Takeda, S; Takei, I	1
Brown, LJ; Forbes, LV; Scott, RS	1
Bell, JI; Lo, YM; Patel, P; Wainscoat, JS	1
Chauffert, M; Chevenne, D; Cisse, A; Michel, S; Parfait, B; Trivin, F	1
Chung, YS; Fugisawa, T; Fujisawa, T; Huh, KB; Ikegami, H; Kim, DH; Kim, KR; Kim, YS; Lee, DS; Lee, EJ; Lee, HC; Lim, SK; Ogihara, T; Park, JO; Park, SW	1
Best, JJ; Deary, IJ; Frier, BM; Perros, P; Sellar, RJ	1
Antoniou, AN; Dyson, PJ; Elliott, J; Rosmarakis, E	1
Boitard, C; Caillat-Zucman, S; Djilali-Saiah, I; Dubois-Laforgue, D; Timsit, J	1
Bowen, J; Maravilla, K; Richards, T	1
Buus, S; Holm, A; Johansen, BH; Paulsen, G; Quarsten, H; Sollid, LM; Thorpe, CJ	1
Bartnes, K; Briand, JP; Hannestad, K; Li, X; Travers, PJ	1
Apostolopoulos, V; Corper, AL; Garcia, KC; Kang, AS; Scott, CA; Stratmann, T; Teyton, L; Wilson, IA	1
Ettinger, RA; Kwok, WW; Liu, AW; Nepom, GT	1
Cheng, H; Fu, Z; Yan, T; Zhang, S; Zhong, G	1
Abramov, N; Arbel, A; Bloch, K; Brautbar, C; Israel, S; Josefsberg, Z; Kwon, OJ; Pinhas-Hamiel, O; Sprecher, E; Vardi, P; Weintrob, N	1
Hamadeh, MJ; Hoffer, LJ	1
Trucco, M	1
Awata, T; Iwamoto, Y; Kanazawa, Y; Kuzuya, T; Matsuda, A	1
Bertera, S; Chantres, MT; Dorman, JS; Gutierrez-Lopez, MD; Serrano-Rios, M; Trucco, M; Vavassori, C	1
Arnaiz-Villena, A; Corell, A; Lledó, G; Martin-Villa, JM; Martinez-Laso, J; Morales, P; Vicario, JL	1
Charron, D; Fauchet, R; Gu, XF; Ju, LY; Krishnamoorty, R; Semana, G; Sun, YP	1
Akerblom, HK; Ilonen, J; Knip, M; Reijonen, H	1
Althoff, P; Boehm, BO; Kühnl, P; Manfras, B; Scherbaum, WA; Schöffling, K; Trucco, M; Usadel, KH	1
Cha, T; Ikegami, H; Noma, Y; Ogihara, T; Shima, K; Tahara, Y; Yamato, E	1
Hammarström, L; Olerup, O; Smith, CI	1
Boehm, BO; Manfras, B; Rosak, C; Schöffling, K; Trucco, M	1
Kikutani, H; Kimoto, M; Kishimoto, T; Miyazaki, J; Miyazaki, T; Nishimoto, H; Uehira, M; Uno, M; Yamamura, K	1
Awata, T; Iwamoto, Y; Juji, T; Kanazawa, Y; Kuzuya, T; Matsuda, A; Okuyama, M	1
Czernichow, P; Elion, J; Krishnamoorthy, R; Lévy-Marchal, C; Tichet, J; Vallet-Colom, I; Zarrouk, D	1
Amemiya, H; Hanafusa, T; Kono, N; Miyagawa, J; Miyazaki, A; Nakajima, H; Noguchi, T; Sada, M; Tanaka, T; Yamagata, K	1
Bao, MZ; Dorman, JS; Trucco, M; Wang, JX	1
Halstensen, TS; Iwe, T; Rønningen, KS; Spurkland, A; Thorsby, E	1
Rusting, R	1
Dorman, JS; McDevitt, HO; Morel, PA; Todd, JA; Trucco, M	1

Reviews

1 review(s) available for aspartic acid and Autoimmune Diabetes

Article	Year
To be or not to be Asp 57, that is the question. Diabetes care, 1992, Volume: 15, Issue:5 Topics: Amino Acid Sequence; Aspartic Acid; Child; Diabetes Mellitus, Type 1; Genetic Markers; Haplotypes; Histocompatibility Antigens Class I; HLA-D Antigens; Humans; Major Histocompatibility Complex; Polymorphism, Restriction Fragment Length; Protein Conformation	1992

Trials

2 trial(s) available for aspartic acid and Autoimmune Diabetes

Article	Year
HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan. Diabetes care, 1994, Volume: 17, Issue:8 Topics: Adolescent; Alleles; Aspartic Acid; China; Codon; Diabetes Mellitus, Type 1; Gene Frequency; Genotype; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; Incidence; Reference Values; Regression Analysis; Taiwan	1994
Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea. American journal of physiology. Endocrinology and metabolism, 2001, Volume: 281, Issue:2 Topics: Alanine; Aspartic Acid; Bacterial Proteins; Diabetes Mellitus, Type 1; Diet, Protein-Restricted; Female; Gas Chromatography-Mass Spectrometry; Glutamine; Glycine; Humans; Isoleucine; Leucine; Male; Methionine; Nitrogen Isotopes; Postprandial Period; Spirulina; Urea	2001

Article

Year

HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan.

Diabetes care, 1994, Volume: 17, Issue:8

Topics: Adolescent; Alleles; Aspartic Acid; China; Codon; Diabetes Mellitus, Type 1; Gene Frequency; Genotype; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; Incidence; Reference Values; Regression Analysis; Taiwan

1994

Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea.

American journal of physiology. Endocrinology and metabolism, 2001, Volume: 281, Issue:2

Topics: Alanine; Aspartic Acid; Bacterial Proteins; Diabetes Mellitus, Type 1; Diet, Protein-Restricted; Female; Gas Chromatography-Mass Spectrometry; Glutamine; Glycine; Humans; Isoleucine; Leucine; Male; Methionine; Nitrogen Isotopes; Postprandial Period; Spirulina; Urea

2001

Other Studies

51 other study(ies) available for aspartic acid and Autoimmune Diabetes

Article	Year
Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children. AJNR. American journal of neuroradiology, 2023, Volume: 44, Issue:7 Topics: Aspartic Acid; Brain; Child; Choline; Creatine; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Glycated Hemoglobin; Humans; Pilot Projects; White Matter	2023
Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate. The Journal of biological chemistry, 2023, Volume: 299, Issue:11 Topics: Animals; Aspartic Acid; Diabetes Mellitus, Type 1; Humans; In Vitro Techniques; Insulin; Insulin-Secreting Cells; Mass Spectrometry; Mice; Peptides	2023
Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes. Journal of diabetes and its complications, 2019, Volume: 33, Issue:4 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Peripheral Nerves; Polyneuropathies; White Matter	2019
Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:5 Topics: Adult; Aspartic Acid; Brain; Diabetes Mellitus, Type 1; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Occipital Lobe	2013
Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. Diabetes care, 2014, Volume: 37, Issue:6 Topics: Adolescent; Aspartic Acid; Brain; Child; Cognition Disorders; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Humans; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Recall; Prospective Studies	2014
Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:11 Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Corpus Striatum; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glutamic Acid; Hippocampus; Hypoglycemic Agents; Inositol; Insulin; Magnetic Resonance Spectroscopy; Neurons; Proton Magnetic Resonance Spectroscopy; Rats; Taurine; Visual Cortex	2015
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells. Diabetes/metabolism research and reviews, 2008, Volume: 24, Issue:6 Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; DNA Primers; Female; Insulin-Secreting Cells; Mice; Mice, Inbred Strains; Threonine	2008
Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury. AJNR. American journal of neuroradiology, 2010, Volume: 31, Issue:4 Topics: Adolescent; Aspartic Acid; Basal Ganglia; Blood Glucose; Brain; Brain Damage, Chronic; Brain Edema; Creatine; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Dominance, Cerebral; Humans; Magnetic Resonance Spectroscopy; Male	2010
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T. Journal of neurochemistry, 2012, Volume: 121, Issue:3 Topics: Acute Disease; Algorithms; Animals; Aspartic Acid; Biological Transport, Active; Blood Glucose; Blood-Brain Barrier; Brain Chemistry; Cerebral Cortex; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Progression; Glucose; Glutathione; Hippocampus; Hyperglycemia; Kinetics; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley	2012
Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2003, Volume: 111, Issue:7 Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Chlorides; Choline; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Osmolar Concentration; Potassium; Sodium; Statistics, Nonparametric; Urea	2003
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Diabetes care, 2004, Volume: 27, Issue:1 Topics: Amino Acid Substitution; Aspartic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Genotype; Glycine; Humans; Isoleucine; Membrane Glycoproteins; Mutation, Missense; Odds Ratio; Polymorphism, Single Nucleotide; Prevalence; Receptors, Cell Surface; Threonine; Toll-Like Receptor 4; Toll-Like Receptors; White People	2004
Analysis of children with type 1 diabetes in Korea: high prevalence of specific anti-islet autoantibodies, immunogenetic similarities to Western populations with "unique" haplotypes, and lack of discrimination by aspartic acid at position 57 of DQB. Clinical immunology (Orlando, Fla.), 2004, Volume: 113, Issue:3 Topics: Adolescent; Adult; Aspartic Acid; Autoantibodies; Child; Child, Preschool; Diabetes Mellitus, Type 1; Europe; Haplotypes; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Infant; Islets of Langerhans; Korea; Prevalence	2004
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study. Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:4 Topics: Aged; Albuminuria; Aspartic Acid; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Exons; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Homozygote; Humans; Linkage Disequilibrium; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Promoter Regions, Genetic; Threonine	2005
Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus. Neuroradiology, 2005, Volume: 47, Issue:7 Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Child; Choline; Creatinine; Diabetes Mellitus, Type 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Magnetic Resonance Spectroscopy; Pons	2005
[HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA)]. Medicina, 2005, Volume: 65, Issue:3 Topics: Adolescent; Adult; Age of Onset; Argentina; Aspartic Acid; Autoimmune Diseases; Case-Control Studies; Diabetes Mellitus, Type 1; Gene Frequency; Genotype; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Middle Aged; Odds Ratio; Polymorphism, Genetic	2005
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes. Diabetes care, 2005, Volume: 28, Issue:11 Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glucose; Glutamic Acid; Glutamine; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Inositol; Insulin; Male; Memory; Memory, Short-Term; Methylamines; Neuropsychological Tests; Nuclear Magnetic Resonance, Biomolecular; Time Factors	2005
Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. Pediatric diabetes, 2005, Volume: 6, Issue:4 Topics: Age of Onset; Arginine; Asian People; Aspartic Acid; Autoantibodies; Case-Control Studies; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Progression; Female; Gene Frequency; Genotype; Haplotypes; Humans; Japan; Male; Phenotype	2005
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. Journal of immunology (Baltimore, Md. : 1950), 1995, May-15, Volume: 154, Issue:10 Topics: Amino Acid Sequence; Animals; Antigen-Presenting Cells; Aspartic Acid; Base Sequence; Cyclophosphamide; Diabetes Mellitus, Type 1; Histocompatibility Antigens Class II; Islets of Langerhans; Mice; Mice, Inbred NOD; Mice, Transgenic; Molecular Sequence Data; RNA, Messenger; Sialadenitis; Structure-Activity Relationship; T-Lymphocytes; Transfection	1995
Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study. Diabetes, 1995, Volume: 44, Issue:1 Topics: Adolescent; Amino Acid Sequence; Amino Acids; Arginine; Aspartic Acid; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Gene Amplification; Genotype; HLA-DQ Antigens; Humans; Incidence; Infant; Leucine; Male; Models, Molecular; Molecular Sequence Data; Polymorphism, Genetic; Sweden	1995
Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay. Diabetes research and clinical practice, 1994, Volume: 23, Issue:2 Topics: Adolescent; Adult; Aged; Alleles; Arginine; Aspartic Acid; Child; Child, Preschool; Diabetes Mellitus, Type 1; DNA; DNA Probes; Female; Histocompatibility Antigens Class II; Histocompatibility Testing; Humans; Infant; Infant, Newborn; Japan; Luminescent Measurements; Male; Middle Aged; Oligonucleotide Probes	1994
HLA-DQ beta typing and non-Asp57 alleles in IDDM and nondiabetic subjects in New Zealand. Diabetes care, 1993, Volume: 16, Issue:8 Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Gene Frequency; Genetic Predisposition to Disease; Histocompatibility Testing; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Incidence; New Zealand; Poisson Distribution; Polymorphism, Restriction Fragment Length; Reference Values; Registries; Risk Factors	1993
Rapid HLA typing by multiplex amplification refractory mutation system. Journal of clinical pathology, 1993, Volume: 46, Issue:12 Topics: Alleles; Arginine; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Disease Susceptibility; DNA Primers; Gene Amplification; Genes, MHC Class II; Histocompatibility Testing; HLA-DR3 Antigen; HLA-DR4 Antigen; Humans; Molecular Sequence Data; Polymerase Chain Reaction	1993
HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of Senegal. Diabetes care, 1995, Volume: 18, Issue:5 Topics: Adolescent; Adult; Alleles; Aspartic Acid; Black People; Child; Diabetes Mellitus, Type 1; Female; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Histocompatibility Testing; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; Male; Native Hawaiian or Other Pacific Islander; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Racial Groups; Reference Values; Risk Factors; Senegal; Valine	1995
Role of HLA class II alleles in Korean patients with IDDM. Diabetes research and clinical practice, 1996, Volume: 31, Issue:1-3 Topics: Adult; Alleles; Arginine; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Genes, MHC Class II; Genetic Variation; HLA-DQ alpha-Chains; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR Antigens; Humans; Korea; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Reference Values	1996
Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia. Diabetes care, 1997, Volume: 20, Issue:6 Topics: Adult; Aspartic Acid; Atrophy; Blood Glucose; Brain; Cerebral Cortex; Choline; Cognition; Cohort Studies; Creatine; Diabetes Mellitus, Type 1; Female; Humans; Hypoglycemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged	1997
MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection. Immunogenetics, 1998, Volume: 47, Issue:3 Topics: Amino Acid Sequence; Animals; Antibodies; Arginine; Aspartic Acid; Cells, Cultured; Diabetes Mellitus, Type 1; Female; Graft Rejection; H-2 Antigens; Haplotypes; Male; Mice; Mice, Inbred CBA; Mice, Inbred NOD; Molecular Sequence Data; Receptors, Antigen, T-Cell; Skin Transplantation; Spleen; T-Lymphocytes	1998
Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects. Human immunology, 1997, Volume: 57, Issue:2 Topics: Adolescent; Adult; Alleles; Aspartic Acid; Autoantibodies; Child; Diabetes Mellitus, Type 1; Haplotypes; HLA-DQ alpha-Chains; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR Antigens; HLA-DR3 Antigen; HLA-DR4 Antigen; HLA-DRB1 Chains; Humans; Islets of Langerhans; Middle Aged	1997
MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:2 Topics: Adult; Amino Acid Substitution; Aspartic Acid; Basal Ganglia; Base Sequence; Brain; Cerebral Cortex; Choline; Creatine; Deafness; Diabetes Mellitus, Type 1; DNA Mutational Analysis; DNA, Mitochondrial; Female; Follow-Up Studies; Genotype; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Mitochondrial Encephalomyopathies; RNA, Transfer, Leu	1998
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules. International immunology, 1998, Volume: 10, Issue:8 Topics: Alanine; Alleles; Aspartic Acid; B-Lymphocytes; Binding Sites; Cell Line; Computer Simulation; Diabetes Mellitus, Type 1; Genes, MHC Class II; Genetic Predisposition to Disease; Histocompatibility Antigens Class II; HLA-DQ Antigens; Humans; Models, Molecular; Mutagenesis, Site-Directed; Peptide Library; Peptides; Protein Engineering; Static Electricity; Transfection	1998
The P9 peptide sidechain specificity of I-Ad. Immunology letters, 1999, Dec-01, Volume: 70, Issue:3 Topics: Animals; Antigen Presentation; Aspartic Acid; Capsid; Capsid Proteins; Cross Reactions; Diabetes Mellitus, Type 1; Epitopes; Genetic Predisposition to Disease; Histocompatibility Antigens Class II; Keratitis, Herpetic; Mice; Oligopeptides; Polymorphism, Genetic; Protein Binding; Structure-Activity Relationship; T-Lymphocytes; Viral Proteins	1999
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science (New York, N.Y.), 2000, Apr-21, Volume: 288, Issue:5465 Topics: Alleles; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspartic Acid; Crystallography, X-Ray; Diabetes Mellitus, Type 1; Drosophila melanogaster; Genes, MHC Class II; Glutamate Decarboxylase; Histocompatibility Antigens Class II; Humans; Hydrogen Bonding; Mice; Mice, Inbred NOD; Models, Molecular; Molecular Sequence Data; Peptide Library; Protein Binding; Protein Conformation; Protein Structure, Secondary; Receptors, Antigen, T-Cell; Recombinant Proteins	2000
Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA10102/DQB10602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus. Journal of immunology (Baltimore, Md. : 1950), 2000, Sep-15, Volume: 165, Issue:6 Topics: Alleles; Amino Acid Substitution; Antigens, Differentiation, B-Lymphocyte; Aspartic Acid; Cell Line, Transformed; Cell-Free System; Diabetes Mellitus, Type 1; Dimerization; Genetic Predisposition to Disease; Histocompatibility Antigens Class II; HLA-DQ alpha-Chains; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Membrane Glycoproteins; Mutagenesis, Site-Directed; Protein Binding; Sodium Dodecyl Sulfate	2000
Contribution of the absence of aspartic acid at position 57 of the HLA-DQ beta chain to predisposition to insulin-dependent diabetes mellitus in a southern Chinese population. Chinese medical journal, 1998, Volume: 111, Issue:8 Topics: Adolescent; Adult; Alleles; Asian People; Aspartic Acid; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Genetic Predisposition to Disease; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Male; Middle Aged; Phenotype	1998
Type 1 diabetes environmental factors and correspondence analysis of HLA class II genes in the Yemenite Jewish community in Israel. Diabetes care, 2001, Volume: 24, Issue:4 Topics: Adult; Aged; Alleles; Animals; Aspartic Acid; Cattle; Diabetes Mellitus, Type 1; Emigration and Immigration; Environment; Ethnicity; Female; Genes, MHC Class II; Genotype; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; Infant; Infant Food; Infections; Israel; Jews; Male; Milk; Odds Ratio; Reference Values; Yemen	2001
Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia, 1992, Volume: 35, Issue:5 Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Gene Frequency; Genes, MHC Class II; Genetic Predisposition to Disease; Genotype; HLA-D Antigens; Humans; Japan; Molecular Sequence Data; Oligonucleotide Probes	1992
Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles. Diabetologia, 1992, Volume: 35, Issue:6 Topics: Alleles; Arginine; Aspartic Acid; Base Sequence; Cells, Cultured; Diabetes Mellitus, Type 1; Disease Susceptibility; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DQ alpha-Chains; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; Lymphocytes; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotide Probes; Polymerase Chain Reaction; Reference Values; Risk Factors; Spain	1992
Exclusive HLA-DQ factors do not explain susceptibility to insulin-dependent diabetes. Human immunology, 1991, Volume: 31, Issue:2 Topics: Alleles; Arginine; Aspartic Acid; Diabetes Mellitus, Type 1; DNA Probes; Histocompatibility Testing; HLA-DQ Antigens; HLA-DR Antigens; Humans; Polymorphism, Restriction Fragment Length; Risk Factors	1991
Aspartic acid at position 57 of the HLA-DQ beta chain in insulin-dependent diabetes mellitus: an association with one DRw9-DQw9 subtype in the Chinese population. Tissue antigens, 1991, Volume: 37, Issue:5 Topics: Alleles; Asian People; Aspartic Acid; Base Sequence; China; Diabetes Mellitus, Type 1; Disease Susceptibility; DNA; Haplotypes; Heterozygote; Histocompatibility Antigens Class II; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR Antigens; HLA-DR Serological Subtypes; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length	1991
HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland. Diabetes, 1991, Volume: 40, Issue:12 Topics: Adolescent; Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Disease Susceptibility; Finland; Genetic Predisposition to Disease; Genotype; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Reference Values	1991
Prevalence of HLA-DQ beta chain non-Asp alleles in type I (insulin-dependent) diabetics with young and older ages of onset. Klinische Wochenschrift, 1991, Oct-02, Volume: 69, Issue:15 Topics: Adolescent; Adult; Alleles; Aspartic Acid; Chi-Square Distribution; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; HLA-DQ Antigens; HLA-DR3 Antigen; HLA-DR4 Antigen; Humans; Male; Middle Aged	1991
Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people. Journal of autoimmunity, 1990, Volume: 3, Issue:2 Topics: Amino Acids; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; HLA-DQ Antigens; Humans; Japan; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length	1990
Different amino acids at position 57 of the HLA-DQ beta chain associated with susceptibility and resistance to IgA deficiency. Nature, 1990, Sep-20, Volume: 347, Issue:6290 Topics: Amino Acid Sequence; Aspartic Acid; Diabetes Mellitus, Type 1; Disease Susceptibility; Genetic Markers; Haplotypes; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; IgA Deficiency; Molecular Sequence Data; Polymorphism, Restriction Fragment Length	1990
Aspartic acid at position 57 of the HLA-DQ beta chain is protective against future development of insulin-dependent (type 1) diabetes mellitus. Klinische Wochenschrift, 1991, Feb-26, Volume: 69, Issue:4 Topics: Adult; Amino Acid Sequence; Aspartic Acid; Autoantibodies; Diabetes Mellitus, Type 1; Female; Genetic Markers; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR Antigens; Humans; Hyperglycemia; Islets of Langerhans; Male; Polymerase Chain Reaction; Risk Factors; Thyroiditis, Autoimmune	1991
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice. Nature, 1990, Jun-21, Volume: 345, Issue:6277 Topics: Animals; Aspartic Acid; Base Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Gene Expression; Histocompatibility Antigens Class II; Islets of Langerhans; Lymphocytes; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oligonucleotide Probes; Protein Conformation; Serine	1990
High frequency of aspartic acid at position 57 of HLA-DQ beta-chain in Japanese IDDM patients and nondiabetic subjects. Diabetes, 1990, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Asian People; Aspartic Acid; Base Sequence; Chromosome Mapping; Diabetes Mellitus, Type 1; DNA; Female; Gene Amplification; Gene Frequency; HLA-DQ Antigens; HLA-DQ beta-Chains; Humans; Immunoblotting; Male; Middle Aged; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotides; Polymerase Chain Reaction	1990
HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children. Diabetologia, 1990, Volume: 33, Issue:3 Topics: Alanine; Alleles; Aspartic Acid; Child; Codon; Diabetes Mellitus, Type 1; France; Gene Frequency; Genetic Predisposition to Disease; HLA-DQ Antigens; HLA-DQ beta-Chains; Homozygote; Humans; RNA, Messenger	1990
Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia, 1989, Volume: 32, Issue:10 Topics: Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Genes, MHC Class II; Genetic Predisposition to Disease; Histocompatibility Antigens Class II; HLA-DQ Antigens; Humans; Immunity, Innate; Japan; Macromolecular Substances; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction	1989
HLA-DQ beta non-ASP-57 allele and incidence of diabetes in China and the USA. Lancet (London, England), 1989, Aug-26, Volume: 2, Issue:8661 Topics: Alleles; Aspartic Acid; China; Chromosome Mapping; Diabetes Mellitus, Type 1; Disease Susceptibility; Heterozygote; HLA-DQ Antigens; Humans; Pennsylvania	1989
The amino acid at position 57 of the HLA-DQ beta chain and susceptibility to develop insulin-dependent diabetes mellitus. Human immunology, 1989, Volume: 26, Issue:3 Topics: Adolescent; Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Diabetes Mellitus, Type 1; Disease Susceptibility; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Genotype; HLA-DQ Antigens; HLA-DR Antigens; Humans; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Random Allocation; Taq Polymerase	1989
The 57th variety. Scientific American, 1988, Volume: 258, Issue:1 Topics: Amino Acid Sequence; Animals; Aspartic Acid; Diabetes Mellitus, Type 1; Genetic Therapy; HLA-DQ Antigens; Humans; Insulin; Mice	1988
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:21 Topics: Aspartic Acid; Base Sequence; Codon; Diabetes Mellitus, Type 1; Disease Susceptibility; Female; Haploidy; HLA-DQ Antigens; Humans; Male; Molecular Sequence Data; Pedigree; Polymorphism, Genetic	1988