aspartic acid has been researched along with Autistic Disorder in 34 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The neuropeptide oxytocin may be an effective therapeutic strategy for the currently untreatable social and communication deficits associated with autism." | 9.20 | Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial. ( Abe, O; Aoki, Y; Iwashiro, N; Kasai, K; Kawakubo, Y; Kuwabara, H; Natsubori, T; Takano, Y; Takao, H; Watanabe, T; Yahata, N; Yamasue, H, 2015) |
| "An Australian patient with autism was found to be heterozygous for two mutations in the gene encoding adenylosuccinate lyase (ASL), resulting in the protein mutations E80D and D87E." | 7.72 | Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL. ( Colman, RF; Cowley, D; McGown, I; Patterson, D; Sivendran, S; Spiegel, E, 2004) |
| "The neuropeptide oxytocin may be an effective therapeutic strategy for the currently untreatable social and communication deficits associated with autism." | 5.20 | Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial. ( Abe, O; Aoki, Y; Iwashiro, N; Kasai, K; Kawakubo, Y; Kuwabara, H; Natsubori, T; Takano, Y; Takao, H; Watanabe, T; Yahata, N; Yamasue, H, 2015) |
| "In 22 children with autism, 5 to 16 years old, and 20 age-matched healthy control subjects, (1)H-MRSI assessed levels of N-acetyl compounds (NAA), choline compounds (Cho), and creatine plus phosphocreatine (Cr) at 272 msec echo-time and 1." | 3.72 | Proton magnetic resonance spectroscopic imaging of the brain in childhood autism. ( Alger, JR; Blanton, RE; Fadale, D; Guthrie, D; Levitt, JG; McCracken, JT; O'Neill, J; Smalley, S; Toga, AW, 2003) |
| "An Australian patient with autism was found to be heterozygous for two mutations in the gene encoding adenylosuccinate lyase (ASL), resulting in the protein mutations E80D and D87E." | 3.72 | Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL. ( Colman, RF; Cowley, D; McGown, I; Patterson, D; Sivendran, S; Spiegel, E, 2004) |
| "© 2015 International Society for Autism Research, Wiley Periodicals, Inc." | 1.43 | Biochemistry of the cingulate cortex in autism: An MR spectroscopy study. ( Kana, RK; Lahti, AC; Libero, LE; Reid, MA; Salibi, N; White, DM, 2016) |
| "The diagnosis of autism was established by neurologist, psychiatrist and psychologist in every case." | 1.38 | Metabolite alterations in autistic children: a 1H MR spectroscopy study. ( Kubas, B; Kułak, W; Lebkowska, U; Sobaniec, W; Tarasow, E; Walecki, J, 2012) |
| "Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development." | 1.38 | Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. ( Abe, O; Aoki, Y; Gonoi, W; Inoue, H; Iwashiro, N; Kasai, K; Kato, N; Katsura, M; Kawakubo, Y; Kunimatsu, A; Kuwabara, H; Matsuzaki, H; Murakami, M; Natsubori, T; Nippashi, Y; Sasaki, H; Takano, Y; Takao, H; Tsuchiya, KJ; Yahata, N; Yamasue, H, 2012) |
| "Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder." | 1.35 | 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders. ( Azizian, A; DeVincent, C; Gabis, L; Kesner-Baruch, Y; Pomeroy, J; Roche, P; Tudorica, A, 2008) |
| " Dosage analysis of PTEN was carried out using multiplex ligation-dependent probe amplification (MLPA)." | 1.34 | Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. ( Anckarsäter, H; Betancur, C; Buxbaum, JD; Cai, G; Chaste, P; Gillberg, C; Goldsmith, J; Hollander, E; Leboyer, M; Nygren, G; Rastam, M; Reichert, J; Silverman, JM; Smith, CJ; Verloes, A, 2007) |
| "Rett syndrome is characterized by disruption of a period of vigorous brain growth with synapse development." | 1.32 | Neurotrophic factors in the pathogenesis of Rett syndrome. ( Riikonen, R, 2003) |
| "A strong association of autism with SNPs within the SLC25A12 gene was demonstrated." | 1.32 | Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. ( Bespalova, IN; Buxbaum, JD; Davis, KL; Ramoz, N; Reichert, JG; Silverman, JM; Smith, CJ, 2004) |
| "Autism is a neuro-developmental syndrome that affects 0." | 1.32 | Disorder-associated mutations lead to functional inactivation of neuroligins. ( Afridi, SK; Chih, B; Clark, L; Scheiffele, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 20 (58.82) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Grechanyi, SV | 1 |
| Suf El-Zhil, LR | 1 |
| Ivanov, DO | 1 |
| Pozdnyakova, OF | 1 |
| Sergeev, AM | 1 |
| Atamanova, EE | 1 |
| Pozdnyakov, AV | 1 |
| Aoki, Y | 2 |
| Watanabe, T | 1 |
| Abe, O | 2 |
| Kuwabara, H | 2 |
| Yahata, N | 2 |
| Takano, Y | 2 |
| Iwashiro, N | 2 |
| Natsubori, T | 2 |
| Takao, H | 2 |
| Kawakubo, Y | 2 |
| Kasai, K | 2 |
| Yamasue, H | 2 |
| Libero, LE | 1 |
| Reid, MA | 1 |
| White, DM | 1 |
| Salibi, N | 1 |
| Lahti, AC | 1 |
| Kana, RK | 1 |
| Hardan, AY | 1 |
| Minshew, NJ | 1 |
| Melhem, NM | 1 |
| Srihari, S | 1 |
| Jo, B | 1 |
| Bansal, R | 1 |
| Keshavan, MS | 1 |
| Stanley, JA | 1 |
| Kleinhans, NM | 2 |
| Richards, T | 1 |
| Weaver, KE | 1 |
| Liang, O | 1 |
| Dawson, G | 3 |
| Aylward, E | 1 |
| Suzuki, K | 1 |
| Nishimura, K | 1 |
| Sugihara, G | 1 |
| Nakamura, K | 1 |
| Tsuchiya, KJ | 2 |
| Matsumoto, K | 1 |
| Takebayashi, K | 1 |
| Isoda, H | 1 |
| Sakahara, H | 1 |
| Sugiyama, T | 1 |
| Tsujii, M | 1 |
| Takei, N | 1 |
| Mori, N | 1 |
| Fujii, E | 1 |
| Mori, K | 5 |
| Miyazaki, M | 2 |
| Hashimoto, T | 3 |
| Harada, M | 6 |
| Kagami, S | 1 |
| Taki, MM | 1 |
| Nose, A | 1 |
| Kubo, H | 1 |
| Nishitani, H | 3 |
| Matsuda, T | 1 |
| Rodríguez-Escudero, I | 1 |
| Oliver, MD | 1 |
| Andrés-Pons, A | 1 |
| Molina, M | 1 |
| Cid, VJ | 1 |
| Pulido, R | 1 |
| Kubas, B | 1 |
| Kułak, W | 1 |
| Sobaniec, W | 1 |
| Tarasow, E | 1 |
| Lebkowska, U | 1 |
| Walecki, J | 1 |
| Inoue, H | 1 |
| Gonoi, W | 1 |
| Sasaki, H | 1 |
| Murakami, M | 1 |
| Katsura, M | 1 |
| Nippashi, Y | 1 |
| Kunimatsu, A | 1 |
| Matsuzaki, H | 1 |
| Kato, N | 1 |
| Perich-Alsina, J | 1 |
| Aduna de Paz, M | 1 |
| Valls, A | 1 |
| Muñoz-Yunta, JA | 1 |
| Friedman, SD | 2 |
| Shaw, DW | 2 |
| Artru, AA | 2 |
| Richards, TL | 1 |
| Gardner, J | 1 |
| Posse, S | 1 |
| Dager, SR | 2 |
| Riikonen, R | 1 |
| Levitt, JG | 1 |
| O'Neill, J | 1 |
| Blanton, RE | 1 |
| Smalley, S | 1 |
| Fadale, D | 1 |
| McCracken, JT | 1 |
| Guthrie, D | 1 |
| Toga, AW | 1 |
| Alger, JR | 1 |
| Ramoz, N | 1 |
| Reichert, JG | 1 |
| Smith, CJ | 2 |
| Silverman, JM | 2 |
| Bespalova, IN | 1 |
| Davis, KL | 1 |
| Buxbaum, JD | 2 |
| Chih, B | 1 |
| Afridi, SK | 1 |
| Clark, L | 1 |
| Scheiffele, P | 1 |
| Sivendran, S | 1 |
| Patterson, D | 1 |
| Spiegel, E | 1 |
| McGown, I | 1 |
| Cowley, D | 1 |
| Colman, RF | 1 |
| Castillo, M | 1 |
| Fayed, N | 1 |
| Modrego, PJ | 1 |
| Petropoulos, H | 1 |
| Correia, C | 1 |
| Coutinho, AM | 1 |
| Diogo, L | 1 |
| Grazina, M | 1 |
| Marques, C | 1 |
| Miguel, T | 1 |
| Ataíde, A | 1 |
| Almeida, J | 1 |
| Borges, L | 1 |
| Oliveira, C | 1 |
| Oliveira, G | 1 |
| Vicente, AM | 1 |
| Cai, G | 1 |
| Chaste, P | 1 |
| Nygren, G | 1 |
| Goldsmith, J | 1 |
| Reichert, J | 1 |
| Anckarsäter, H | 1 |
| Rastam, M | 1 |
| Hollander, E | 1 |
| Leboyer, M | 1 |
| Gillberg, C | 1 |
| Verloes, A | 1 |
| Betancur, C | 1 |
| Schweinsburg, BC | 1 |
| Cohen, DN | 1 |
| Müller, RA | 1 |
| Courchesne, E | 1 |
| Endo, T | 1 |
| Shioiri, T | 1 |
| Kitamura, H | 1 |
| Kimura, T | 1 |
| Endo, S | 2 |
| Masuzawa, N | 1 |
| Someya, T | 1 |
| Vasconcelos, MM | 1 |
| Brito, AR | 1 |
| Domingues, RC | 1 |
| da Cruz, LC | 1 |
| Gasparetto, EL | 1 |
| Werner, J | 1 |
| Gonçalves, JP | 1 |
| Gabis, L | 1 |
| Azizian, A | 1 |
| DeVincent, C | 1 |
| Tudorica, A | 1 |
| Kesner-Baruch, Y | 1 |
| Roche, P | 1 |
| Pomeroy, J | 1 |
| Rolf, LH | 1 |
| Haarmann, FY | 1 |
| Grotemeyer, KH | 1 |
| Kehrer, H | 1 |
| Tayama, M | 1 |
| Yoneda, Y | 2 |
| Yoshimoto, T | 1 |
| Miyoshi, H | 1 |
| Tanouchi, M | 1 |
| Kuroda, Y | 1 |
| Kawano, N | 1 |
| Fukuda, K | 1 |
| Yamaue, T | 1 |
| Miyoshi, K | 1 |
| Chugani, DC | 1 |
| Sundram, BS | 1 |
| Behen, M | 1 |
| Lee, ML | 1 |
| Moore, GJ | 1 |
| Otsuka, H | 1 |
| Hisaoka, S | 2 |
| Bottini, N | 1 |
| De Luca, D | 1 |
| Saccucci, P | 1 |
| Fiumara, A | 1 |
| Elia, M | 1 |
| Porfirio, MC | 1 |
| Lucarelli, P | 1 |
| Curatolo, P | 1 |
2 trials available for aspartic acid and Autistic Disorder
| Article | Year |
|---|---|
Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial.
Topics: Administration, Intranasal; Adult; Aspartic Acid; Autistic Disorder; Double-Blind Method; Female; Hu | 2015 |
Regional brain chemical alterations in young children with autism spectrum disorder.
Topics: Age Distribution; Age Factors; Aspartic Acid; Autistic Disorder; Brain; Cell Count; Child, Preschool | 2003 |
32 other studies available for aspartic acid and Autistic Disorder
| Article | Year |
|---|---|
[Proton magnetic resonance spectroscopy in children with atypical autism comorbid with psychomotor disinhibition syndrome].
Topics: Aspartic Acid; Autistic Disorder; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spect | 2021 |
Biochemistry of the cingulate cortex in autism: An MR spectroscopy study.
Topics: Adult; Aspartic Acid; Autistic Disorder; Choline; Creatine; Female; Gyrus Cinguli; Humans; Magnetic | 2016 |
An MRI and proton spectroscopy study of the thalamus in children with autism.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Child; Choline; Creatine; Dominance, Cerebral; Humans; | 2008 |
Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder.
Topics: Adolescent; Adult; Amygdala; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Brain Mapping; Cas | 2009 |
Metabolite alterations in the hippocampus of high-functioning adult subjects with autism.
Topics: Adolescent; Adult; Aggression; Aspartic Acid; Autistic Disorder; Cerebellum; Choline; Creatine; Hipp | 2010 |
Function of the frontal lobe in autistic individuals: a proton magnetic resonance spectroscopic study.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Choline; Creatine; Female; Fr | 2010 |
Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument.
Topics: Analysis of Variance; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Corpus Striatum; Fr | 2011 |
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Autistic Disorder; Catalytic Domain; DNA Mutational Ana | 2011 |
Metabolite alterations in autistic children: a 1H MR spectroscopy study.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Child; Choline; Creatine; Female; gamma-Aminobutyric A | 2012 |
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Humans; Magnetic Res | 2012 |
[Thalamic spectroscopy using magnetic resonance in autism].
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Choline; Creatinine; Humans; | 2002 |
Neurotrophic factors in the pathogenesis of Rett syndrome.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Brain-Derived Neurotrophic Factor; Child; Child, Presc | 2003 |
Proton magnetic resonance spectroscopic imaging of the brain in childhood autism.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Brain; Brain Mapping; Case-Control Studies; Child; Chi | 2003 |
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; Chromosomes, Human, Pair 2; DNA Mutational Ana | 2004 |
Disorder-associated mutations lead to functional inactivation of neuroligins.
Topics: Animals; Arginine; Aspartic Acid; Autistic Disorder; Carrier Proteins; Cell Adhesion Molecules, Neur | 2004 |
Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Amino Acid Sequence; Arginine; Aspartic Acid; Autis | 2004 |
Autism and ADHD: common disorders, elusive explanations.
Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain Chemistry; Ce | 2005 |
Comparative study of cerebral white matter in autism and attention-deficit/hyperactivity disorder by means of magnetic resonance spectroscopy.
Topics: Analysis of Variance; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Autistic Disorde | 2005 |
Gray and white matter brain chemistry in young children with autism.
Topics: Aspartic Acid; Autistic Disorder; Brain; Brain Chemistry; Child, Preschool; Choline; Creatine; Cross | 2006 |
Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; DNA Mutational Analysis; DNA Primers; DNA, Mit | 2006 |
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
Topics: Abnormalities, Multiple; Adolescent; Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Autistic | 2007 |
N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activation.
Topics: Adolescent; Adult; Aspartic Acid; Autistic Disorder; Brain; Brain Mapping; Case-Control Studies; Hum | 2007 |
Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders.
Topics: Adolescent; Adult; Amygdala; Aspartic Acid; Autistic Disorder; Brain Mapping; Child; Female; Hippoca | 2007 |
Proton magnetic resonance spectroscopy in school-aged autistic children.
Topics: Analysis of Variance; Aspartic Acid; Autistic Disorder; Brain; Brain Chemistry; Case-Control Studies | 2008 |
1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders.
Topics: Adolescent; Amygdala; Analysis of Variance; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Bio | 2008 |
Serotonin and amino acid content in platelets of autistic children.
Topics: Adolescent; Amino Acids; Aspartic Acid; Autistic Disorder; Biomarkers; Blood Platelets; Child; Chrom | 1993 |
Differences in brain metabolites between patients with autism and mental retardation as detected by in vivo localized proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Autistic Disorder; Brain; Child; Child, Preschool; Choline; Creatine; Female; Humans; | 1997 |
Proton magnetic resonance spectroscopy of the brain in three cases of Rett syndrome: comparison with autism and normal controls.
Topics: Adolescent; Adult; Aspartic Acid; Autistic Disorder; Brain; Child; Child, Preschool; Choline; Creati | 1998 |
Evidence of altered energy metabolism in autistic children.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Brain; Cerebellum; Child; Child, Preschool; Energy Met | 1999 |
Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: an 1H-MR spectroscopy study.
Topics: Adolescent; Amygdala; Aspartic Acid; Autistic Disorder; Brain; Brain Chemistry; Case-Control Studies | 1999 |
Autism: evidence of association with adenosine deaminase genetic polymorphism.
Topics: Adenosine Deaminase; Adolescent; Alleles; Amino Acid Substitution; Asparagine; Aspartic Acid; Autist | 2001 |
Regional magnetic resonance spectroscopy of the brain in autistic individuals.
Topics: Adolescent; Adult; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Female; Humans; Infant | 2001 |