Page last updated: 2024-11-08

aspartic acid and Argininosuccinate Synthase Deficiency Disease

aspartic acid has been researched along with Argininosuccinate Synthase Deficiency Disease in 10 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Research Excerpts

ExcerptRelevanceReference
" Here, we show that ASS1 functions as a tumor suppressor in breast cancer, and the pesticide spinosyn A (SPA) and its derivative LM-2I suppress breast tumor cell proliferation and growth by binding to and activating ASS1."4.02Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor. ( Cao, D; Chen, C; Chen, L; Chen, X; Hu, X; Kong, F; Li, J; Li, X; Liu, O; Liu, S; Luo, J; Luo, T; Luo, W; Luo, Z; Ma, D; Ming, Z; Peng, K; Wen, M; Xia, L; Xie, Y; Xu, N; Yang, C; Yi, W; Zou, Z, 2021)
"Citrullinemia type 1 is an autosomal-recessive urea cycle disorder caused by mutations in the ASS1 gene and characterised by increased plasma citrulline concentrations."3.83Kinetic mutations in argininosuccinate synthetase deficiency: characterisation and in vitro correction by substrate supplementation. ( Diez-Fernandez, C; Fingerhut, R; Gemperle, C; Häberle, J; Rüfenacht, V; Wellauer, O, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's3 (30.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Tavoulari, S1
Lacabanne, D1
Thangaratnarajah, C1
Kunji, ERS1
Yau, WW1
Chen, GB1
Zhou, J1
Francisco, JC1
Thimmukonda, NK1
Li, S1
Singh, BK1
Yen, PM1
Zou, Z1
Hu, X1
Luo, T1
Ming, Z1
Chen, X1
Xia, L1
Luo, W1
Li, J1
Xu, N1
Chen, L1
Cao, D1
Wen, M1
Kong, F1
Peng, K1
Xie, Y1
Li, X1
Ma, D1
Yang, C1
Chen, C1
Yi, W1
Liu, O1
Liu, S1
Luo, J1
Luo, Z1
Saheki, T4
Moriyama, M3
Kuroda, E1
Funahashi, A1
Yasuda, I1
Setogawa, Y1
Gao, Q1
Ushikai, M1
Furuie, S1
Yamamura, KI1
Takano, K1
Nakamura, Y2
Eto, K1
Kadowaki, T1
Sinasac, DS3
Furukawa, T1
Horiuchi, M3
Tai, YH1
Rabinovich, S1
Adler, L1
Yizhak, K1
Sarver, A1
Silberman, A1
Agron, S1
Stettner, N1
Sun, Q1
Brandis, A1
Helbling, D1
Korman, S1
Itzkovitz, S1
Dimmock, D1
Ulitsky, I1
Nagamani, SC1
Ruppin, E1
Erez, A1
Diez-Fernandez, C1
Wellauer, O1
Gemperle, C1
Rüfenacht, V1
Fingerhut, R1
Häberle, J1
Jalil, MA1
Begum, L1
Li, MX2
Iijima, M2
Robinson, BH1
Kobayashi, K3
Tsui, LC2
Kannan, Y1
Tanaka, M1
Fiermonte, G1
Soon, D1
Chaudhuri, A1
Paradies, E1
Lee, PJ1
Krywawych, S1
Palmieri, F1
Lachmann, RH1

Reviews

2 reviews available for aspartic acid and Argininosuccinate Synthase Deficiency Disease

ArticleYear
Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency.
    Trends in endocrinology and metabolism: TEM, 2022, Volume: 33, Issue:8

    Topics: Adult; Aspartic Acid; Calcium; Citrullinemia; Glutamates; Humans; Infant, Newborn; Mitochondrial Mem

2022
[Molecular basis of citrin deficiency].
    Seikagaku. The Journal of Japanese Biochemical Society, 2004, Volume: 76, Issue:12

    Topics: Aspartic Acid; Calcium; Calcium-Binding Proteins; Cholestasis, Intrahepatic; Chromosome Mapping; Cit

2004

Other Studies

8 other studies available for aspartic acid and Argininosuccinate Synthase Deficiency Disease

ArticleYear
Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency.
    Human molecular genetics, 2023, 05-18, Volume: 32, Issue:11

    Topics: Aspartic Acid; Citrullinemia; Fatty Acids; Glycolysis; Hepatocytes; Humans; Hyperammonemia; Malates;

2023
Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor.
    Nature communications, 2021, 04-15, Volume: 12, Issue:1

    Topics: Adult; Aged; Animals; Argininosuccinate Synthase; Aspartic Acid; Breast; Breast Neoplasms; Cell Line

2021
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.
    Scientific reports, 2019, 03-12, Volume: 9, Issue:1

    Topics: Amino Acids; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Citrulline; Citrullinemia; Disease

2019
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
    Nature, 2015, Nov-19, Volume: 527, Issue:7578

    Topics: Animals; Argininosuccinate Synthase; Aspartate Carbamoyltransferase; Aspartic Acid; Calcium-Binding

2015
Kinetic mutations in argininosuccinate synthetase deficiency: characterisation and in vitro correction by substrate supplementation.
    Journal of medical genetics, 2016, Volume: 53, Issue:10

    Topics: Argininosuccinate Synthase; Aspartic Acid; Catalytic Domain; Citrulline; Citrullinemia; Humans; Kine

2016
Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.
    Molecular and cellular biology, 2004, Volume: 24, Issue:2

    Topics: Amino Acids; Ammonia; Animals; Argininosuccinate Synthase; Aspartic Acid; Base Sequence; Citrullinem

2004
Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice.
    Journal of hepatology, 2006, Volume: 44, Issue:5

    Topics: Amino Acids; Ammonia; Animals; Anticoagulants; Aspartic Acid; Calcium-Binding Proteins; Citric Acid;

2006
An adult with type 2 citrullinemia presenting in Europe.
    The New England journal of medicine, 2008, Mar-27, Volume: 358, Issue:13

    Topics: Adult; Aspartic Acid; Biological Transport, Active; Citrullinemia; Europe; Fatal Outcome; Glutamic A

2008
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