aspartic acid has been researched along with Angina Pectoris in 7 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zaremba, YK | 1 |
| Zaremba, OV | 1 |
| Fedchyshyn, NR | 1 |
| Tkachenko, VI | 1 |
| Kapustynskyy, OO | 1 |
| Ogimoto, A | 1 |
| Shigematsu, Y | 1 |
| Nakura, J | 1 |
| Hara, Y | 1 |
| Ohtsuka, T | 1 |
| Kohara, K | 1 |
| Hamada, M | 1 |
| Miki, T | 1 |
| Higaki, J | 1 |
| Vanhanen, I | 1 |
| Håkanson, E | 1 |
| Jorfeldt, L | 1 |
| Svedjeholm, R | 1 |
| Cai, H | 1 |
| Wang, X | 1 |
| Colagiuri, S | 1 |
| Wilcken, DE | 1 |
| Khogali, SE | 1 |
| Pringle, SD | 1 |
| Weryk, BV | 1 |
| Rennie, MJ | 1 |
| Krüger, K | 1 |
| Dockweiler, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827] | Phase 3 | 865 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| Oral Glutamine Reduces Myocardial Damage After Coronary Revascularization Under Cardiopulmonary Bypass[NCT02491931] | 28 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 147 |
| Saline Infusion | 152 |
ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay
| Intervention | hours (Median) |
|---|---|
| Intravenous Glutamate | 21 |
| Saline Infusion | 21 |
(NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 31 |
| Saline Infusion | 25 |
Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 4 |
| Saline Infusion | 6 |
Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 1 |
| Saline Infusion | 5 |
maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days
| Intervention | µmol/L (Mean) |
|---|---|
| Intravenous Glutamate | 106 |
| Saline Infusion | 106 |
Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 3 |
| Saline Infusion | 16 |
p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative
| Intervention | µg/L (Median) | |
|---|---|---|
| CK-MB day 1 | Troponin-T day 3 | |
| Intravenous Glutamate | 14 | 0.27 |
| Saline Infusion | 14 | 0.24 |
Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU
| Intervention | percentage of saturated hemoglobin (Mean) | |
|---|---|---|
| SvO2 at weaning from CPB | SvO2 on arrival to ICU | |
| Intravenous Glutamate | 72.0 | 65.0 |
| Saline Infusion | 72.2 | 64.9 |
1 trial available for aspartic acid and Angina Pectoris
| Article | Year |
|---|---|
Is glutamine beneficial in ischemic heart disease?
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aged; Angina Pectoris; Animals; | 2002 |
6 other studies available for aspartic acid and Angina Pectoris
| Article | Year |
|---|---|
THE INCREASE OF EFFICIENCY OF TREATMENT IN PATIENTS WITH NON-STABLE ANGINA PECTORIS WITH USE OF NITROGEN OXIDE DONATOR
Topics: Aged; Angina Pectoris; Arginine; Aspartic Acid; Drug Therapy, Combination; Female; Humans; Male; Mid | 2018 |
Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina.
Topics: Amino Acid Substitution; Angina Pectoris; Aspartic Acid; Cardiomyopathy, Hypertrophic; Female; Gluta | 2005 |
Intravenous aspartate infusion after a coronary operation: effects on myocardial metabolism and hemodynamic state.
Topics: Alanine; Angina Pectoris; Aspartic Acid; Blood Glucose; Cardiac Catheterization; Coronary Artery Byp | 1998 |
A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes.
Topics: Albuminuria; Amino Acid Substitution; Angina Pectoris; Aspartic Acid; Cerebrovascular Disorders; Dia | 1998 |
[Metabolic therapeutic possibilities of ischemic heart disease].
Topics: Angina Pectoris; Aspartic Acid; Coronary Disease; Electrocardiography; Female; Humans; Hypertension; | 1967 |
[Treatment of coronary heart disease from the modern point of view].
Topics: Adult; Angina Pectoris; Animals; Aspartic Acid; Blood Circulation; Coronary Disease; Coronary Vessel | 1968 |