aspartic acid has been researched along with Amyotrophic Lateral Sclerosis in 105 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was conducted to examine the effect of lamotrigine (LTG) in amyotrophic lateral sclerosis (ALS)." | 9.10 | A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters. ( Askmark, H; Persson, LI; Ryberg, H, 2003) |
| "A study was conducted to examine the effect of lamotrigine (LTG) in amyotrophic lateral sclerosis (ALS)." | 5.10 | A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters. ( Askmark, H; Persson, LI; Ryberg, H, 2003) |
| "Riluzole, a glutamate antagonist, has been shown to be efficacious in the treatment of patients with amyotrophic lateral sclerosis (ALS), allowing prolonged survival and time to tracheostomy." | 5.08 | Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. ( Arnold, DL; Cashman, NR; Genge, A; Kalra, S, 1998) |
| "Changes in the distribution of the proton magnetic resonance spectroscopy (MRS) observed metabolites N-acetyl aspartate (NAA), total-choline (Cho), and total-creatine (Cre) in the entire intracranial corticospinal tract (CST) including the primary motor cortex were evaluated in patients with amyotrophic lateral sclerosis (ALS)." | 3.78 | Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. ( Arheart, KL; Govind, V; Maudsley, AA; Saigal, G; Sharma, KR; Sheriff, S, 2012) |
| "The Aspartate-90-Alanine (D90A) mutation on SOD-1 gene, the only known change causing recessive familial amyotrophic lateral sclerosis (FALS), is associated with a uniform phenotype characterized by slowly ascending paresis and long survival." | 3.71 | A screening for superoxide dismutase-1 D90A mutation in Italian patients with sporadic amyotrophic lateral sclerosis. ( Del Corona, A; Filosto, M; Mancuso, M; Murri, L; Naini, A; Rocchi, A; Sartucci, F; Siciliano, G, 2002) |
| "Frontotemporal lobar degeneration is responsible for the cognitive abnormalities seen in patients with ALS." | 2.76 | Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study. ( Camicioli, R; Choi, C; Johnston, W; Kalra, S; Lynch, M; Sekhon, R; Seres, P; Usman, U, 2011) |
| "However, an objective measure of disease progression and therapeutic response is sorely needed." | 2.40 | Biological markers in the diagnosis and treatment of ALS. ( Arnold, DL; Cashman, NR; Kalra, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.95) | 18.7374 |
| 1990's | 30 (28.57) | 18.2507 |
| 2000's | 37 (35.24) | 29.6817 |
| 2010's | 33 (31.43) | 24.3611 |
| 2020's | 4 (3.81) | 2.80 |
| Authors | Studies |
|---|---|
| Natera-de Benito, D | 1 |
| Olival, J | 1 |
| Garcia-Cabau, C | 1 |
| Jou, C | 1 |
| Roldan, M | 1 |
| Codina, A | 1 |
| Expósito-Escudero, J | 1 |
| Batlle, C | 1 |
| Carrera-García, L | 1 |
| Ortez, C | 1 |
| Salvatella, X | 1 |
| Palau, F | 1 |
| Nascimento, A | 1 |
| Hoenicka, J | 1 |
| Blicher, JU | 1 |
| Eskildsen, SF | 1 |
| Stærmose, TG | 1 |
| Møller, AT | 1 |
| Figlewski, K | 1 |
| Near, J | 1 |
| Canosa, A | 1 |
| Grassano, M | 1 |
| Barberis, M | 1 |
| Brunetti, M | 1 |
| Manera, U | 1 |
| Vasta, R | 1 |
| Cammarosano, S | 1 |
| De Marco, G | 1 |
| Calvo, A | 1 |
| Chiò, A | 1 |
| Moglia, C | 1 |
| Sako, W | 2 |
| Izumi, Y | 2 |
| Abe, T | 2 |
| Haji, S | 1 |
| Murakami, N | 1 |
| Osaki, Y | 1 |
| Matsumoto, Y | 1 |
| Harada, M | 2 |
| Kaji, R | 2 |
| Ta, D | 1 |
| Ishaque, A | 1 |
| Srivastava, O | 1 |
| Hanstock, C | 3 |
| Seres, P | 2 |
| Eurich, DT | 1 |
| Luk, C | 1 |
| Briemberg, H | 1 |
| Frayne, R | 1 |
| Genge, AL | 1 |
| Graham, SJ | 1 |
| Korngut, L | 1 |
| Zinman, L | 1 |
| Kalra, S | 10 |
| Atassi, N | 1 |
| Xu, M | 1 |
| Triantafyllou, C | 1 |
| Keil, B | 1 |
| Lawson, R | 1 |
| Cernasov, P | 1 |
| Ratti, E | 1 |
| Long, CJ | 1 |
| Paganoni, S | 1 |
| Murphy, A | 1 |
| Salibi, N | 1 |
| Seethamraju, R | 1 |
| Rosen, B | 1 |
| Ratai, EM | 1 |
| Piaceri, I | 1 |
| Bessi, V | 1 |
| Matà, S | 1 |
| Polito, C | 1 |
| Tedde, A | 1 |
| Berti, V | 1 |
| Bagnoli, S | 1 |
| Braccia, A | 1 |
| Del Mastio, M | 1 |
| Pignone, AM | 1 |
| Pupi, A | 1 |
| Sorbi, S | 1 |
| Nacmias, B | 1 |
| Cheong, I | 1 |
| Deelchand, DK | 1 |
| Eberly, LE | 1 |
| Marjańska, M | 1 |
| Manousakis, G | 1 |
| Guliani, G | 1 |
| Walk, D | 1 |
| Öz, G | 1 |
| de Munck, E | 1 |
| Muñoz-Sáez, E | 1 |
| Miguel, BG | 1 |
| Solas, MT | 1 |
| Ojeda, I | 1 |
| Martínez, A | 1 |
| Gil, C | 1 |
| Arahuetes, RM | 1 |
| D'Angelo, S | 1 |
| Trojsi, F | 1 |
| Salvatore, A | 1 |
| Daniele, L | 1 |
| Raimo, M | 1 |
| Galletti, P | 1 |
| Monsurrò, MR | 2 |
| Shi, Y | 1 |
| Rhodes, NR | 1 |
| Abdolvahabi, A | 1 |
| Kohn, T | 1 |
| Cook, NP | 1 |
| Marti, AA | 1 |
| Shaw, BF | 1 |
| Cervo, A | 1 |
| Cocozza, S | 1 |
| Saccà, F | 1 |
| Giorgio, SMDA | 1 |
| Morra, VB | 1 |
| Tedeschi, E | 1 |
| Marsili, A | 1 |
| Vacca, G | 1 |
| Palma, V | 1 |
| Brunetti, A | 1 |
| Quarantelli, M | 1 |
| Barthelme, D | 1 |
| Jauregui, R | 1 |
| Sauer, RT | 1 |
| García Santos, JM | 1 |
| Inuggi, A | 1 |
| Gómez Espuch, J | 1 |
| Vázquez, C | 1 |
| Iniesta, F | 1 |
| Blanquer, M | 1 |
| María Moraleda, J | 1 |
| Martínez, S | 1 |
| Corsini, S | 1 |
| Tortora, M | 1 |
| Nistri, A | 2 |
| Wang, Y | 2 |
| Li, X | 1 |
| Chen, W | 1 |
| Wang, Z | 1 |
| Xu, Y | 1 |
| Luo, J | 1 |
| Lin, H | 1 |
| Sun, G | 1 |
| Mali, Y | 2 |
| Zisapels, N | 1 |
| Pyra, T | 2 |
| Hui, B | 2 |
| Concha, L | 1 |
| Wong, JC | 1 |
| Beaulieu, C | 1 |
| Johnston, W | 3 |
| Kosuge, Y | 1 |
| Sekikawa-Nishida, K | 1 |
| Negi, H | 1 |
| Ishige, K | 1 |
| Ito, Y | 1 |
| Fiszman, ML | 1 |
| Ricart, KC | 1 |
| Latini, A | 1 |
| Rodríguez, G | 1 |
| Sica, RE | 1 |
| Choi, JK | 1 |
| Küstermann, E | 1 |
| Dedeoglu, A | 1 |
| Jenkins, BG | 1 |
| Young, K | 1 |
| Govind, V | 2 |
| Sharma, K | 1 |
| Studholme, C | 1 |
| Maudsley, AA | 6 |
| Schuff, N | 5 |
| Lombardo, F | 1 |
| Frijia, F | 1 |
| Bongioanni, P | 1 |
| Canapicchi, R | 1 |
| Minichilli, F | 1 |
| Bianchi, F | 1 |
| Hlavata, H | 1 |
| Rossi, B | 1 |
| Montanaro, D | 1 |
| Zisapel, N | 1 |
| Sivák, S | 1 |
| Bittšanský, M | 1 |
| Kurča, E | 1 |
| Turčanová-Koprušáková, M | 1 |
| Grofik, M | 1 |
| Nosál', V | 1 |
| Poláček, H | 1 |
| Dobrota, D | 1 |
| Nagańska, E | 1 |
| Taraszewska, A | 1 |
| Matyja, E | 1 |
| Grieb, P | 1 |
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| Georgoulopoulou, E | 1 |
| Gellera, C | 1 |
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| Sola, P | 1 |
| Chiari, A | 1 |
| Bernabei, C | 1 |
| Mandrioli, J | 1 |
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| Caraballo-Miralles, V | 1 |
| Olmos, G | 1 |
| Lladó, J | 1 |
| Sudharshan, N | 1 |
| Cifra, A | 1 |
| Nani, F | 1 |
| Usman, U | 1 |
| Choi, C | 1 |
| Camicioli, R | 1 |
| Lynch, M | 1 |
| Sekhon, R | 1 |
| Del Grande, A | 1 |
| Conte, A | 1 |
| Lattante, S | 1 |
| Luigetti, M | 1 |
| Marangi, G | 1 |
| Zollino, M | 1 |
| Madia, F | 1 |
| Bisogni, G | 1 |
| Sabatelli, M | 1 |
| Carew, JD | 1 |
| Nair, G | 1 |
| Andersen, PM | 2 |
| Wuu, J | 1 |
| Gronka, S | 1 |
| Hu, X | 1 |
| Benatar, M | 1 |
| Simone, IL | 2 |
| Ruggieri, M | 1 |
| Tortelli, R | 1 |
| Ceci, E | 1 |
| D'Errico, E | 1 |
| Leo, A | 1 |
| Zoccolella, S | 1 |
| Mastrapasqua, M | 1 |
| Capozzo, R | 1 |
| Livrea, P | 1 |
| Logroscino, G | 1 |
| Uccelli, A | 1 |
| Milanese, M | 2 |
| Principato, MC | 1 |
| Morando, S | 1 |
| Bonifacino, T | 2 |
| Vergani, L | 1 |
| Giunti, D | 1 |
| Voci, A | 1 |
| Carminati, E | 1 |
| Giribaldi, F | 2 |
| Caponnetto, C | 1 |
| Bonanno, G | 2 |
| Foerster, BR | 1 |
| Callaghan, BC | 1 |
| Petrou, M | 1 |
| Edden, RA | 1 |
| Chenevert, TL | 1 |
| Feldman, EL | 1 |
| Sharma, KR | 1 |
| Arheart, KL | 1 |
| Saigal, G | 1 |
| Sheriff, S | 2 |
| Anna Rossi, PI | 1 |
| Di Prisco, S | 1 |
| Pittaluga, A | 1 |
| Tacchetti, C | 1 |
| Puliti, A | 1 |
| Usai, C | 1 |
| Stagg, CJ | 1 |
| Knight, S | 1 |
| Talbot, K | 1 |
| Jenkinson, M | 1 |
| Turner, MR | 1 |
| Verma, G | 1 |
| Woo, JH | 2 |
| Chawla, S | 1 |
| Wang, S | 2 |
| Elman, LB | 2 |
| McCluskey, LF | 2 |
| Grossman, M | 1 |
| Melhem, ER | 2 |
| Poptani, H | 2 |
| Cashman, NR | 4 |
| Caramanos, Z | 1 |
| Genge, A | 4 |
| Arnold, DL | 6 |
| Mancuso, M | 1 |
| Filosto, M | 1 |
| Naini, A | 2 |
| Rocchi, A | 1 |
| Del Corona, A | 1 |
| Sartucci, F | 1 |
| Siciliano, G | 1 |
| Murri, L | 1 |
| Shigeri, Y | 1 |
| Shimamoto, K | 1 |
| Ryberg, H | 1 |
| Askmark, H | 1 |
| Persson, LI | 1 |
| Sato, T | 1 |
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| Nakanishi, T | 1 |
| Fukada, K | 1 |
| Sugai, F | 1 |
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| Cai, Y | 1 |
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| Guo, X | 1 |
| Rule, RR | 1 |
| Suhy, J | 2 |
| Gelinas, DF | 1 |
| Miller, RG | 3 |
| Weiner, MW | 4 |
| Banci, L | 1 |
| Bertini, I | 1 |
| D'Amelio, N | 1 |
| Gaggelli, E | 1 |
| Libralesso, E | 1 |
| Matecko, I | 1 |
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| Hemptinne, I | 1 |
| Vanhoutte, N | 1 |
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| Maloteaux, JM | 1 |
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| Krejza, J | 1 |
| Conforti, FL | 1 |
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| Ungaro, C | 1 |
| Tessitore, A | 1 |
| Tedeschi, G | 1 |
| Patitucci, A | 1 |
| Magariello, A | 1 |
| Gabriele, A | 1 |
| Labella, V | 1 |
| Majorana, G | 1 |
| Valentino, P | 1 |
| Muglia, M | 1 |
| Quattrone, A | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Vitale, A | 1 |
| Mehrazin, M | 1 |
| Lu, J | 1 |
| Gordon, P | 1 |
| Mitsumoto, H | 4 |
| Huang, H | 1 |
| Tan, K | 1 |
| Chen, L | 1 |
| Xue, Y | 1 |
| Wang, H | 1 |
| Xi, H | 1 |
| Liu, Y | 1 |
| Zhang, F | 1 |
| Zhang, J | 1 |
| Unrath, A | 1 |
| Ludolph, AC | 2 |
| Kassubek, J | 1 |
| Niessen, HG | 1 |
| Debska-Vielhaber, G | 1 |
| Sander, K | 1 |
| Angenstein, F | 1 |
| Hilfert, L | 1 |
| Willker, W | 1 |
| Leibfritz, D | 1 |
| Heinze, HJ | 2 |
| Kunz, WS | 2 |
| Vielhaber, S | 2 |
| Ulug, AM | 1 |
| Pullman, SL | 1 |
| Gooch, CL | 1 |
| Chan, S | 2 |
| Tang, MX | 1 |
| Mao, X | 1 |
| Hays, AP | 1 |
| Floyd, AG | 1 |
| Battista, V | 1 |
| Montes, J | 1 |
| Hayes, S | 1 |
| Dashnaw, S | 1 |
| Kaufmann, P | 1 |
| Gordon, PH | 1 |
| Hirsch, J | 1 |
| Levin, B | 1 |
| Rowland, LP | 2 |
| Shungu, DC | 2 |
| Jones, AP | 2 |
| Gunawardena, WJ | 1 |
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| Gatt, JA | 1 |
| Shaw, IC | 2 |
| Mitchell, JD | 1 |
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| Møller, SE | 1 |
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| Rothstein, JD | 4 |
| Jin, L | 1 |
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| Kuncl, RW | 2 |
| Plaitakis, A | 2 |
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| Giroud, M | 1 |
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| Pioro, EP | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis[NCT02405182] | 145 participants (Actual) | Observational | 2014-09-30 | Completed | |||
| The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism: A Comparison With Risperidone in First Episode Psychosis[NCT05890768] | Phase 4 | 35 participants (Anticipated) | Interventional | 2023-05-11 | Recruiting | ||
| Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics[NCT04649008] | Early Phase 1 | 290 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Muscle Ultrasound: A New Tool for Measuring Progression in ALS[NCT00838617] | 10 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis[NCT00023075] | 55 participants | Observational | 2001-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspartic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
[Excitatory amino acid transporters: development of regulatory molecules for their functional analysis].
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Drug Design; Excitatory Amino Acid Antagonist | 2003 |
ALS surrogate markers. MRS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; Humans; Longitudinal Studies; Ma | 2004 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Biological markers in the diagnosis and treatment of ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Progression; Elec | 1999 |
[Proton MR spectroscopy studies of the brain in ALS patients].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Disease Progression; Female; Front | 2001 |
9 trials available for aspartic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Choli | 2015 |
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusio | 2009 |
Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar | 2011 |
A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain Chemistry; Brain-Derived Neur | 2003 |
A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Over S | 2003 |
Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis).
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnet | 1995 |
Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Excitatory Amino Acid Antagonists; Female | 1998 |
Motor unit hyperexcitability in amyotrophic lateral sclerosis vs amino acids acting as neurotransmitters.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressur | 2002 |
Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressur | 2002 |
91 other studies available for aspartic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Common pathophysiology for ANXA11 disorders caused by aspartate 40 variants.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Humans; Motor Neurons; Muscular Diseases; Mutation | 2023 |
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; | 2019 |
A familial amyotrophic lateral sclerosis pedigree discordant for a novel p.Glu46Asp heterozygous OPTN variant and the p.Ala5Val heterozygous SOD1 missense mutation.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Cycle Proteins; Female; Genetic Testing; | 2020 |
MR spectroscopy and imaging-derived measurements in the supplementary motor area for biomarkers of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Humans; Magnetic Resonance Imaging; Magnet | 2021 |
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progressio | 2021 |
Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; | 2017 |
Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; C9orf72 Protein; Cognitive Dysfunction; DNA Muta | 2018 |
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression | 2019 |
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Cre | 2013 |
Accumulation of altered aspartyl residues in erythrocyte membrane proteins from patients with sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Erythrocyte Membrane; Female; Humans; Mal | 2013 |
Deamidation of asparagine to aspartate destabilizes Cu, Zn superoxide dismutase, accelerates fibrillization, and mirrors ALS-linked mutations.
Topics: Amyotrophic Lateral Sclerosis; Asparagine; Aspartic Acid; Humans; Models, Molecular; Molecular Struc | 2013 |
An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication.
Topics: Adenosine Triphosphatases; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Cycle Proteins; Humans | 2015 |
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional S | 2016 |
Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: Magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell- and Tissue-Based Therapy; Creatine; Femal | 2016 |
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Brain Stem; Endoplasmic Re | 2016 |
Detecting neuronal dysfunction of hand motor cortex in ALS: A MRSI study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Creatine; Female; F | 2017 |
Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Line; Cytosol; Humans; Malate Dehydrogen | 2008 |
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease P | 2010 |
Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 12; Cell Death; Cell Survival; Diseas | 2009 |
In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; | 2010 |
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, | 2009 |
Multivariate statistical mapping of spectroscopic imaging data.
Topics: Adult; Algorithms; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Choline; Creatin | 2010 |
VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.
Topics: Aminooxyacetic Acid; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Carbon Dioxide; Cell Lin | 2010 |
Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatinine; Female; Humans; Magneti | 2010 |
Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Membrane; Cytoplasm; Endoplasmic Reticul | 2010 |
A novel SOD1 mutation in a young amyotrophic lateral sclerosis patient with a very slowly progressive clinical course.
Topics: Adult; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Disease Progr | 2010 |
TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Death; Excitatory Amino Acid Transporter | 2011 |
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; M | 2011 |
Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Astrocytes; Bicuculline; B | 2011 |
D11Y SOD1 mutation and benign ALS: a consistent genotype-phenotype correlation.
Topics: Aged; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Genetic Associa | 2011 |
Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross- | 2011 |
Serum N-acetylaspartate level in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; | 2011 |
Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Movement; Central Nervous System; Diseas | 2012 |
Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Sect | 2012 |
Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Choline; Creatine; Humans; Hydrogen; Mag | 2012 |
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Anima | 2013 |
Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS.
Topics: Aged; Amyotrophic Lateral Sclerosis; Anisotropy; Aspartic Acid; Brain; Case-Control Studies; Creatin | 2013 |
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline | 2013 |
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline | 2013 |
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline | 2013 |
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline | 2013 |
Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy.
Topics: Acetates; Aged; Amines; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Survival; Creatine; Cyclo | 2003 |
A screening for superoxide dismutase-1 D90A mutation in Italian patients with sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; DNA Pri | 2002 |
Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, Liquid; DNA Mutational A | 2004 |
Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Mapping; Case-Control Studies; Creatine; | 2004 |
Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Cross-S | 2004 |
Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Binding Sites; Circular Dichroism; Copper; Crystalliza | 2005 |
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Aspartic Acid; Astrocytes; Bl | 2006 |
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T.
Topics: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion | 2006 |
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Aci | 2006 |
Cerebral degeneration predicts survival in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Female; Humans; Magnetic R | 2006 |
Identification of a novel D109Y mutation in Cu/Zn superoxide dismutase (sod1) gene associated with amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Catalytic Doma | 2007 |
MR spectroscopy evaluation and short-term outcome of olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Transplantation; Creatine; Female; | 2007 |
Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Aspartic Acid; Choline; Creatine; | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Mo | 2007 |
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; | 2007 |
Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis.
Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic A | 1995 |
[3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Autoradiography; Femal | 1994 |
[Free amino acid contents in the spinal cord of amyotrophic lateral sclerosis].
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Glutamic Acid; | 1993 |
Changes in CSF amino acid concentrations during the evolution of amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Humans; | 1994 |
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biological Transport, Active; Choline O-Acety | 1993 |
Altered metabolism of excitatory amino acids, N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Dipeptides; Humans; Middle Aged; S | 1993 |
Reduced brain N-acetyl-aspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Death; Female; Frontal Lobe; Humans; Magnet | 1996 |
Identification of brain metabolites by magnetic resonance spectroscopy in MND/ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Chemistry; Creatine; gamma-Aminobutyric A | 1996 |
Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebellum; Choline; Creatine; Female; Hu | 1997 |
Increased CSF glutamate following injection of ALS immunoglobulins.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Glutamic Acid; Immunoglobulins; Injections, I | 1997 |
CuZn-superoxide dismutase, extracellular superoxide dismutase, and glutathione peroxidase in blood from individuals homozygous for Asp90Ala CuZu-superoxide dismutase mutation.
Topics: Alanine; Alleles; Amyotrophic Lateral Sclerosis; Aspartic Acid; Erythrocytes; Genetic Carrier Screen | 1998 |
Quantification of brain metabolites in ALS by localized proton magnetic spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Humans; Magnetic Resonan | 1998 |
Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Humans; Magnetic Resonance Imagin | 1998 |
Expression, purification, and characterization of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chelating Agents; Co | 1998 |
A proton magnetic resonance spectroscopic study in ALS: correlation with clinical findings.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatinine; Humans; Magnetic Res | 1998 |
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Mod | 1998 |
The free radical-generating function of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Free Radicals; Human | 1998 |
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Gluta | 1999 |
Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS).
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Death; Chromatography, High P | 1999 |
Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resona | 1999 |
1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Chemistry; Creatine; Humans; Magnet | 1999 |
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Ani | 2000 |
[Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Electromyography; Female; Glutamic | 2000 |
CuZn-superoxide dismutase gene in sporadic amyotrophic lateral sclerosis patients from Russia: Asp90Ala (D90A) mutation and novel rare polymorphism IVS3+35 A>C.
Topics: Adult; Aged; Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Asian People; Aspartic | 2000 |
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; | 2001 |
1H spectroscopy in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Case-Control Studies; Choline; Cre | 2001 |
Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Fr | 2001 |
Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Electric Stimulation; Female; Hu | 2001 |
Effect of creatine supplementation on metabolite levels in ALS motor cortices.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnet | 2001 |
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans | 2002 |
Reduction in metabolite transverse relaxation times in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Stem; Choline; Creatine; Humans; Magnetic Resona | 2002 |
Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biopsy; Collagen; Female; Glutamate | 1992 |
[Familial amyotrophic lateral sclerosis associated with Huntington chorea with increased aspartate level in the cerebrospinal fluid].
Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Fem | 1992 |
Excitatory amino acids in amyotrophic lateral sclerosis: an update.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Glut | 1991 |
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.
Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Di | 1991 |
Excitatory amino acids in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Huma | 1991 |
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Dipeptides; Female; Glutamat | 1990 |
The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cerebellar Cortex; Cerebral | 1988 |