aspartic acid has been researched along with Alcohol Drinking in 15 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex." | 7.11 | Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022) |
| "Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex." | 3.11 | Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022) |
| "Alcohol use disorder is one of the leading causes of disability worldwide." | 2.80 | Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial. ( Berrettini, W; Gordon, AJ; Leong, SH; Lynch, KG; O'Brien, CP; Oslin, DW; Rukstalis, M, 2015) |
| "Recent studies demonstrated that alcohol dependence and excessive alcohol consumption are associated with increased rates of obesity." | 1.36 | Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study. ( Durazzo, TC; Gazdzinski, S; Meyerhoff, DJ; Mon, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Grodin, EN | 1 |
| Nieto, SJ | 1 |
| Meredith, LR | 1 |
| Burnette, E | 1 |
| O'Neill, J | 1 |
| Alger, J | 1 |
| London, ED | 1 |
| Miotto, K | 1 |
| Evans, CJ | 1 |
| Irwin, MR | 1 |
| Ray, LA | 2 |
| Prisciandaro, JJ | 2 |
| Schacht, JP | 2 |
| Prescot, AP | 2 |
| Renshaw, PF | 2 |
| Brown, TR | 2 |
| Anton, RF | 2 |
| Griffin, WC | 1 |
| Haun, HL | 1 |
| Hazelbaker, CL | 1 |
| Ramachandra, VS | 1 |
| Becker, HC | 1 |
| Oslin, DW | 1 |
| Leong, SH | 1 |
| Lynch, KG | 1 |
| Berrettini, W | 1 |
| O'Brien, CP | 1 |
| Gordon, AJ | 1 |
| Rukstalis, M | 1 |
| Zahr, NM | 1 |
| Carr, RA | 1 |
| Rohlfing, T | 1 |
| Mayer, D | 1 |
| Sullivan, EV | 1 |
| Colrain, IM | 1 |
| Pfefferbaum, A | 1 |
| Durazzo, TC | 2 |
| Pathak, V | 1 |
| Gazdzinski, S | 2 |
| Mon, A | 2 |
| Meyerhoff, DJ | 3 |
| Hutchison, KE | 1 |
| Ashenhurst, JR | 1 |
| Morrow, AL | 1 |
| Weiner, MW | 1 |
| Neylan, TC | 1 |
| Hlavin, J | 1 |
| Ramage, ER | 1 |
| McCoy, D | 1 |
| Studholme, C | 1 |
| Cardenas, V | 1 |
| Marmar, C | 1 |
| Truran, D | 1 |
| Chu, PW | 1 |
| Kornak, J | 1 |
| Furlong, CE | 1 |
| McCarthy, C | 1 |
| Hermann, D | 1 |
| Sartorius, A | 1 |
| Welzel, H | 1 |
| Walter, S | 1 |
| Skopp, G | 1 |
| Ende, G | 1 |
| Mann, K | 1 |
| Singh, AK | 1 |
| Gupta, S | 1 |
| Jiang, Y | 1 |
| Sepúlveda, C | 1 |
| Bustos, G | 1 |
| Gysling, K | 1 |
| Seguel, M | 1 |
| Labarca, R | 1 |
| Braunová, Z | 1 |
| Kasparová, S | 1 |
| Mlynárik, V | 1 |
| Mierisová, S | 1 |
| Liptaj, T | 1 |
| Tkác, I | 1 |
| Gvozdjáková, A | 1 |
| Olbrich, R | 1 |
| Watzl, H | 1 |
| Völter, M | 1 |
| Siedow, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenetic Response to Naltrexone for Alcohol Dependence[NCT00831272] | Phase 4 | 221 participants (Actual) | Interventional | 2009-01-05 | Completed | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Effects of Cannabidiol (CBD) on the Brain[NCT04831294] | 15 participants (Actual) | Interventional | 2021-07-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00831272)
Timeframe: 12 weeks
| Intervention | percentage of heavy drinking days (Mean) |
|---|---|
| Naltrexone Group ASP 40 Group | 18.9 |
| Placebo Group ASP 40 Group | 17.9 |
| Naltrexone Group ASN 40 Group | 14.5 |
| Placebo Group ASN 40 Group | 21.7 |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
4 trials available for aspartic acid and Alcohol Drinking
| Article | Year |
|---|---|
Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.
Topics: Alcohol Drinking; Alcoholism; Animals; Aspartic Acid; C-Reactive Protein; Choline; Creatine; Humans; | 2022 |
Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Asparagine; Aspartic Acid; Double-Blind Method; Drug A | 2015 |
Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Amino Acid Substitution; Aspartic Acid; Double-Blind M | 2010 |
[Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study].
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Brain Damage, Chronic; Double-Blind Method; Huma | 1991 |
11 other studies available for aspartic acid and Alcohol Drinking
| Article | Year |
|---|---|
Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Case-Control Studies; Female; gamma-Aminobutyric | 2019 |
Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice.
Topics: Alcohol Drinking; Alcoholism; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Bridged Bic | 2014 |
Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Biomarkers; Female; Glutamic Acid; Gyrus Cinguli | 2016 |
Brain metabolite levels in recently sober individuals with alcohol use disorder: Relation to drinking variables and relapse.
Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Aspartic Acid; Brain; Choline; Chronic Dise | 2016 |
Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Brain; Creatine; Female; Follow-Up Studies; Huma | 2010 |
Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Aspartic Acid; Body Mass Index; Brain; Choline; Creatine; | 2010 |
The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder.
Topics: Adult; Alcohol Drinking; Aspartic Acid; Basal Ganglia; Comorbidity; Female; Humans; Magnetic Resonan | 2011 |
Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users.
Topics: Adult; Alcohol Drinking; Aspartic Acid; Attention; Creatine; Globus Pallidus; Gyrus Cinguli; Hair; H | 2007 |
Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Aspartic Acid; Brain; Central Nervous System Depressants; D | 2008 |
Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus.
Topics: Alcohol Drinking; Animals; Aspartic Acid; Ethanol; Glutamic Acid; Hippocampus; In Vitro Techniques; | 1995 |
Metabolic changes in rat brain after prolonged ethanol consumption measured by 1H and 31P MRS experiments.
Topics: Adenosine Triphosphate; Alcohol Drinking; Alcoholism; Animals; Aspartic Acid; Astrocytes; Brain; Cho | 2000 |