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aspartic acid and Akinetic-Rigid Variant of Huntington Disease

aspartic acid has been researched along with Akinetic-Rigid Variant of Huntington Disease in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (19.23)	18.7374
1990's	11 (21.15)	18.2507
2000's	18 (34.62)	29.6817
2010's	13 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Castro, D; Cepeda, C; Estrada-Sánchez, AM; Jang, K; Levine, MS; Nedjat-Haiem, M; Portillo-Ortiz, K	1
Casseb, RF; Castellano, G; Cendes, F; D'Abreu, A; Lopes-Cendes, I; Ruocco, HH	1
Aylward, EH; Conley, KE; Laurino, MY; Padowski, JM; Richards, TL; Samii, A; Weaver, KE	1
Adams, W; Beglinger, LJ; Fiedorowicz, J; Gasparovic, C; Jorge, R; Magnotta, VA; Paulsen, J; Yager, JR	1
Dumas, EM; Kan, HE; Roos, RA; Teeuwisse, WM; van Buchem, MA; van den Bogaard, SJ; van der Grond, J; Webb, A	1
Bechtel, N; Bohlen, S; Carter, K; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Johnson, HJ; Laule, C; Leavitt, BR; Mackay, AL; Milner, RA; Reilmann, R; Sturrock, A; Tabrizi, SJ; Wyper, K	1
Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H	1
Morton, AJ; Sawiak, SJ; Wood, NI	1
Joseph, SA; Mark, LP; Prost, RW; Reynolds, NC	1
Finkbeiner, S; Greiner, ER; Gu, X; Kodali, R; Mishra, R; Osmand, A; Steffan, JS; Thompson, LM; Wetzel, R; Yang, XW	1
Bechtel, N; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Laule, C; Leavitt, BR; Mackay, AL; Reilmann, R; Sturrock, A; Tabrizi, SJ	1
Ceci, E; de Tommaso, M; Franco, G; Livrea, P; Pica, C; Ruggieri, M; Sciruicchio, V; Serpino, C; Trojano, M	1
Barton, SJ; Bunner, KD; Dorner, JL; Gaither, TW; Klein, EL; Miller, BR; Rebec, GV	1
Barker, PB; Bassett, SS; Brandt, J; Carass, A; Edden, RA; Liu, X; Margolis, RL; Oishi, K; Redgrave, GW; Ross, CA; Shanahan, M; Unschuld, PG; van Zijl, PC; Wang, X	1
Chen, S; Degiacomo, F; Ellerby, LM; Fitzpatrick, J; Gafni, J; Holcomb, J; Howland, D; Kudwa, A; Kwak, S; Lehtimäki, KK; Menalled, L; Miller, S; Papanikolaou, T; Park, H; Park, L; Ramboz, S; Tuunanen, PI; Yang, XW	1
Blamire, AM; Manners, DN; Rajagopalan, B; Schapira, AH; Styles, P; Tabrizi, SJ; Warner, TT	2
Cecil, KM; Doescher, J; Jones, BV; Kiefer, AM; Schapiro, M	1
Mark, LP; Prost, RW; Reynolds, NC	1
Auer, DP; Bender, A; Bender, J; Dose, M; Gasser, T; Klopstock, T; Merl, T; Reilmann, R; Saemann, P; Weindl, A; Yassouridis, A	1
Hanstock, CC; Martin, WR; Wieler, M	1
Cendes, F; Li, LM; Lopes-Cendes, I; Ruocco, HH	1
Leenders, KL; Roos, RA; Sijens, PE; van Oostrom, JC	1
Ross, BD	1
Mangano, RM; Schwarcz, R	2
Lange, HW; Reilmann, R; Rolf, LH	1
Beal, MF; Jenkins, BG; Koroshetz, WJ; Rosen, BR	1
Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E	1
Brooks, DJ; Bryant, DJ; Harding, AE; Marcus, CD; Sargentoni, J; Taylor-Robinson, SD; Weeks, RA	1
Harms, L; Ludolph, AC; Meierkord, H; Pfeiffer, L; Timm, G	1
Carter, RE; Coyle, JT; Passani, LA; Vonsattel, JP	1
Blüml, S; Dubowitz, D; Hoang, TQ; Jacques, DB; Kopyov, OV; Lin, A; Ross, BD; Seymour, K; Tan, J	1
Andreassen, OA; Beal, MF; Ferrante, RJ; Jenkins, BG; Klivenyi, P; Kustermann, E; Rosen, BR	1
Andreassen, OA; Beal, MF; Dedeoglu, A; Ferrante, RJ; Hersch, SM; Jenkins, BG; Kaddurah-Daouk, R; Kubilus, JK; Kuemmerle, S	1
Gramsbergen, JB; Kornblit, BT; Storgaard, J; Zimmer, J	1
Blakemore, C; Cordery, P; Dixon, RM; Hannan, AJ; Styles, P; van Dellen, A; Welch, J; York, D	1
Brundin, P; Hansson, O; Haraldsson, B; Nicniocaill, B; O'Connor, WT	1
Andreassen, OA; Beal, MF; Borchelt, DR; Browne, SE; Dedeoglu, A; Ferrante, KL; Ferrante, RJ; Friedlich, A; Hersch, SM; Jenkins, BG; Ross, CA; Schilling, G; Thomas, M	1
Bates, GP; Kerkerian-Le Goff, L; Liévens, JC; Mahal, A; Samuel, D; Spasic-Boscovic, O; Woodman, B	1
Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Storey, E	1
Dunlop, DS; Lajtha, A; Mc Hale, DM	1
Blin, O; Guieu, R; Nieoullon, A; Pouget, J; Samuel, D; Serratrice, G	1
Albin, RL; Anderson, KD; Balfour, R; Handelin, B; Markel, DS; Penney, JB; Reiner, A; Tourtellotte, WW; Young, AB	1
Beal, MF; Bird, ED; Finn, SF; Martin, JB; Swartz, KJ	1
Meldrum, B	1
Gray, PN; May, PC	1
Cross, AJ; Reynolds, GP; Slater, P	1
Choi, DW; Koh, JY; Peters, S	1
Connick, JH; English, M; Hastings, MH; Stone, TW; Winn, P	1
Arrieta, A; Bonilla, E; Prasad, AL	1
Gerstenbrand, F; Gründig, E; Schedl, R; Simanyi, M; Weiss, H	1

Reviews

2 review(s) available for aspartic acid and Akinetic-Rigid Variant of Huntington Disease

Article	Year
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clinical science (London, England : 1979), 1985, Volume: 68, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats	1985
Endogenous excitotoxic agents. Ciba Foundation symposium, 1987, Volume: 126 Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Glutamic Acid; Humans; Huntington Disease; Models, Neurological; Neurons; Quinolinic Acid; Quinolinic Acids	1987

Article

Year

Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.

Clinical science (London, England : 1979), 1985, Volume: 68, Issue:2

Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats

1985

Endogenous excitotoxic agents.

Ciba Foundation symposium, 1987, Volume: 126

Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Glutamic Acid; Humans; Huntington Disease; Models, Neurological; Neurons; Quinolinic Acid; Quinolinic Acids

1987

Trials

3 trial(s) available for aspartic acid and Akinetic-Rigid Variant of Huntington Disease

Article	Year
Creatine therapy for Huntington's disease: clinical and MRS findings in a 1-year pilot study. Neurology, 2003, Jul-08, Volume: 61, Issue:1 Topics: Adenosine Triphosphate; Aspartic Acid; Brain; Choline; Creatine; Diarrhea; Dietary Supplements; Dose-Response Relationship, Drug; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Muscle, Skeletal; Nausea; Neuropsychological Tests; Phosphocreatine; Pilot Projects; Reference Values; Safety; Treatment Outcome	2003
Creatine supplementation lowers brain glutamate levels in Huntington's disease. Journal of neurology, 2005, Volume: 252, Issue:1 Topics: Administration, Oral; Adult; Aspartic Acid; Brain; Cerebral Cortex; Creatine; Down-Regulation; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurologic Examination; Neuroprotective Agents; Pilot Projects; Treatment Outcome	2005
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study. Neurology, 2005, May-10, Volume: 64, Issue:9 Topics: Administration, Oral; Aspartic Acid; Body Weight; Brain; Creatine; Creatinine; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Neuropsychological Tests; Patient Compliance; Phosphocreatine; Pilot Projects; Treatment Outcome; Up-Regulation	2005

Other Studies

47 other study(ies) available for aspartic acid and Akinetic-Rigid Variant of Huntington Disease

Article	Year
Complete but not partial inhibition of glutamate transporters exacerbates cortical excitability in the R6/2 mouse model of Huntington's disease. CNS neuroscience & therapeutics, 2019, Volume: 25, Issue:4 Topics: Animals; Aspartic Acid; Benzopyrans; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Female; Huntington Disease; Male; Mice; Mice, Transgenic; Organ Culture Techniques	2019
Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Creatine; Deuterium; Dipeptides; Female; Glycerylphosphorylcholine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Activity; Phosphocreatine; Phosphorylcholine; Thalamic Diseases; Thalamus; Trinucleotide Repeats; Young Adult	2013
Neurochemical correlates of caudate atrophy in Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2014, Volume: 29, Issue:3 Topics: Adult; Aged; Aspartic Acid; Atrophy; Caudate Nucleus; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Mutation; Young Adult	2014
Preliminary study of the association of white-matter metabolite concentrations with disease severity in patients with Huntington's disease. The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1 Topics: Aspartic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Nerve Fibers, Myelinated; Protons; Trinucleotide Repeats	2014
Longitudinal metabolite changes in Huntington's disease during disease onset. Journal of Huntington's disease, 2014, Volume: 3, Issue:4 Topics: Adult; Aspartic Acid; Caudate Nucleus; Creatinine; Female; Follow-Up Studies; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Molecular Imaging; Prefrontal Cortex; Putamen	2014
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers. Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:3 Topics: Adult; Analysis of Variance; Aspartic Acid; Biomarkers; Brain; Cross-Sectional Studies; Female; Humans; Huntington Disease; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Putamen; Statistics as Topic; Time Factors; White Matter	2015
Serine 421 regulates mutant huntingtin toxicity and clearance in mice. The Journal of clinical investigation, 2016, 09-01, Volume: 126, Issue:9 Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Models, Animal; Disease Progression; Female; Gait; Genotype; Humans; Huntingtin Protein; Huntington Disease; Male; Maze Learning; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Phenotype; Phosphorylation; Proteasome Endopeptidase Complex; Serine	2016
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy. Journal of Huntington's disease, 2016, 10-01, Volume: 5, Issue:3 Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats	2016
MR-spectroscopic findings in juvenile-onset Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2008, Oct-15, Volume: 23, Issue:13 Topics: Adolescent; Aspartic Acid; Brain Mapping; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Protons; Putamen; Trinucleotide Repeats; Young Adult	2008
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron, 2009, Dec-24, Volume: 64, Issue:6 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Molecular Weight; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Nuclear Proteins; Phenotype; Protein Structure, Tertiary; Serine; Trinucleotide Repeat Expansion	2009
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease. Neurology, 2010, Nov-09, Volume: 75, Issue:19 Topics: Adult; Aspartic Acid; Biomarkers; Cohort Studies; Early Diagnosis; Female; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies; Putamen	2010
Serum levels of N-acetylaspartate in Huntington's disease: preliminary results. Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:2 Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Female; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged	2012
Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease. Journal of neurochemistry, 2012, Volume: 121, Issue:4 Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Aspartic Acid; Ceftriaxone; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Transporter 2; Extracellular Fluid; Genotype; Huntington Disease; Kainic Acid; Male; Mice; Mice, Transgenic; Microinjections; Transcription, Genetic; Up-Regulation	2012
Brain metabolite alterations and cognitive dysfunction in early Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:7 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Cognition Disorders; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Regression Analysis; Trinucleotide Repeat Expansion	2012
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-30, Volume: 32, Issue:22 Topics: Age Factors; Amino Acids; Animals; Aspartic Acid; Body Weight; Brain; Caspase 6; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; Exploratory Behavior; Female; Gene Expression Regulation; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Motor Activity; Nerve Tissue Proteins; Neurons; Proteolysis; RNA, Small Interfering; Rotarod Performance Test; Trinucleotide Repeat Expansion; Ubiquitination	2012
MR imaging and spectroscopy in juvenile Huntington disease. Pediatric radiology, 2004, Volume: 34, Issue:8 Topics: Aspartic Acid; Brain; Caudate Nucleus; Child; Creatinine; Genetic Testing; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Putamen	2004
Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease. Brain research, 2005, Jan-07, Volume: 1031, Issue:1 Topics: Adult; Age of Onset; Aged; Aspartic Acid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Putamen	2005
Is brain lactate increased in Huntington's disease? Journal of the neurological sciences, 2007, Dec-15, Volume: 263, Issue:1-2 Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged	2007
Evidence of thalamic dysfunction in Huntington disease by proton magnetic resonance spectroscopy. Movement disorders : official journal of the Movement Disorder Society, 2007, Oct-31, Volume: 22, Issue:14 Topics: Adult; Age of Onset; Aged; Analysis of Variance; Aspartic Acid; Creatine; Female; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Radionuclide Imaging; Thalamus	2007
1H magnetic resonance spectroscopy in preclinical Huntington disease. Brain research, 2007, Sep-07, Volume: 1168 Topics: Adult; Age Factors; Analysis of Variance; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Female; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	2007
Re: Long-term fetal cell transplant in Huntington disease: stayin' alive. Neurology, 2008, Mar-04, Volume: 70, Issue:10 Topics: Aspartic Acid; Cell Differentiation; Corpus Striatum; Fetal Tissue Transplantation; Graft Survival; Growth Cones; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Monitoring, Physiologic; Neural Pathways; Stem Cell Transplantation	2008
Platelet glutamate and aspartate uptake in Huntington's disease. Journal of neurochemistry, 1981, Volume: 37, Issue:4 Topics: Aspartic Acid; Biological Transport; Blood Platelets; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kinetics; Reference Values	1981
Huntington's disease. Glutamate and aspartate metabolism in blood platelets. Journal of the neurological sciences, 1982, Volume: 53, Issue:3 Topics: Adult; Asparagine; Aspartic Acid; Blood Platelets; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Kinetics; Male; Middle Aged	1982
Huntington's disease: the neuroexcitotoxin aspartate is increased in platelets and decreased in plasma. Journal of the neurological sciences, 1994, Dec-01, Volume: 127, Issue:1 Topics: Adult; Aspartic Acid; Blood Platelets; Blood Proteins; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; Phenylalanine; Plasma	1994
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology, 1993, Volume: 43, Issue:12 Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Humans; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Protons; Reference Values	1993
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3 Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase	1996
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory. Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:2 Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission	1996
Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study. Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:1 Topics: Adult; Aged; Aspartic Acid; Choline; Female; Frontal Lobe; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged	1997
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases. Molecular and chemical neuropathology, 1997, Volume: 31, Issue:2 Topics: Alzheimer Disease; Amino Acids; Antigens, Surface; Aspartic Acid; Brain; Case-Control Studies; Cell Count; Dipeptidases; Dipeptides; Glutamate Carboxypeptidase II; Humans; Huntington Disease; Neurons; Neuropeptides; Reference Values	1997
In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR in biomedicine, 1999, Volume: 12, Issue:4 Topics: Adult; Aspartic Acid; Brain; Fetal Tissue Transplantation; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Parkinson Disease	1999
Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. Journal of neurochemistry, 2000, Volume: 74, Issue:5 Topics: Animals; Aspartic Acid; Blood Glucose; Brain; Glucose; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Neurons; Nonlinear Dynamics; Time Factors	2000
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jun-15, Volume: 20, Issue:12 Topics: Animals; Animals, Genetically Modified; Aspartic Acid; Atrophy; Brain; Corpus Striatum; Creatine; Crosses, Genetic; Dietary Supplements; Female; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred Strains; Motor Activity; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nuclear Proteins	2000
3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate. Experimental neurology, 2000, Volume: 164, Issue:1 Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glucose; Glutamate Decarboxylase; Glutamic Acid; Huntington Disease; In Vitro Techniques; Mitochondria; Nitro Compounds; Propionates; Rats; Succinate Dehydrogenase; Tetrodotoxin	2000
N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice. Neuroreport, 2000, Nov-27, Volume: 11, Issue:17 Topics: Animals; Aspartic Acid; Biomarkers; Calbindins; Choline; Corpus Striatum; Creatine; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Phosphoproteins; S100 Calcium Binding Protein G	2000
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice. The European journal of neuroscience, 2001, Volume: 13, Issue:1 Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Mice; Mice, Transgenic; Microdialysis; N-Methylaspartate; Neurotransmitter Agents; Potassium Chloride	2001
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of disease, 2001, Volume: 8, Issue:3 Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, Animal; Energy Metabolism; Female; Huntingtin Protein; Huntington Disease; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Organ Size; Survival Rate	2001
Impaired glutamate uptake in the R6 Huntington's disease transgenic mice. Neurobiology of disease, 2001, Volume: 8, Issue:5 Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Biological Transport; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Crosses, Genetic; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glial Fibrillary Acidic Protein; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Models, Neurological; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Phenotype; RNA, Messenger; Symporters	2001
The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex. Annals of neurology, 1992, Volume: 32, Issue:4 Topics: Age Factors; Aged; Animals; Aspartic Acid; Brain Chemistry; Cholecystokinin; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; N-Methylaspartate; Neurochemistry; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P	1992
Decreased brain N-acetylaspartate in Huntington's disease. Brain research, 1992, May-15, Volume: 580, Issue:1-2 Topics: Aspartic Acid; Brain; Female; Humans; Huntington Disease; Male	1992
[Familial amyotrophic lateral sclerosis associated with Huntington chorea with increased aspartate level in the cerebrospinal fluid]. Revue neurologique, 1992, Volume: 148, Issue:2 Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Humans; Huntington Disease; Middle Aged	1992
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease. The New England journal of medicine, 1990, May-03, Volume: 322, Issue:18 Topics: Adult; Aspartic Acid; Corpus Striatum; Female; Heterozygote; Humans; Huntington Disease; Immunohistochemistry; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance P; Suicide	1990
Amino acid and neuropeptide neurotransmitters in Huntington's disease cerebellum. Brain research, 1988, Jun-28, Volume: 454, Issue:1-2 Topics: Aged; Aspartic Acid; Cerebellum; Female; Humans; Huntington Disease; Male; Middle Aged; Neuropeptide Y; Neuropeptides; Somatostatin; Substance P	1988
L-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington's disease and normal skin fibroblasts. Life sciences, 1985, Oct-21, Volume: 37, Issue:16 Topics: Aspartic Acid; Cell Survival; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Homocysteine; Humans; Huntington Disease; In Vitro Techniques; Isomerism; Kainic Acid; Kinetics; N-Methylaspartate; Neurotransmitter Agents; Skin; Time Factors	1985
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease. Neuroscience letters, 1986, Jun-18, Volume: 67, Issue:2 Topics: Aged; Aspartic Acid; Brain; Caudate Nucleus; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Paroxetine; Piperidines; Putamen	1986
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity. Science (New York, N.Y.), 1986, Oct-03, Volume: 234, Issue:4772 Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid	1986
Huntington's disease: studies on brain free amino acids. Life sciences, 1988, Volume: 42, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Histidine; Humans; Huntington Disease; Lysine; Male; Middle Aged; Putamen; Serine; Taurine	1988
[Effect of administration of amino acids, especially of L-DOPA and -methyldopa, on the composition of cerebrospinal fluid in extrapyramidal syndromes. 3. Alterations of cerebrospinal fluid in patients with Huntington's chorea after -methyldopa or L-DOPA Zeitschrift fur Neurologie, 1973, Mar-16, Volume: 204, Issue:1 Topics: Adult; Aged; Alanine Transaminase; Asparagine; Aspartic Acid; Child; Dihydroxyphenylalanine; Female; Glutamates; Glutamine; Glycine; Humans; Huntington Disease; Male; Methyldopa; Middle Aged; Phenylalanine; Pyruvates; Threonine	1973