aspartic acid has been researched along with Aging in 374 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment." | 7.91 | Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019) |
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 7.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system." | 7.70 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| " However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment." | 3.91 | Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "The quantification of aspartic acid racemization in the proteins of nonmetabolically active tissues can be used as a measure of chronological aging in humans and other long-lived organisms." | 3.83 | Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens. ( Clarke, SG; Goya, RG; Mansilla, E; Warmack, RA, 2016) |
| " We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)." | 3.76 | Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010) |
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 3.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects." | 3.74 | Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007) |
| "To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men." | 3.72 | Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. ( Breteler, MM; den Heijer, T; Hofman, A; Origgi, D; Oudkerk, M; Sijens, PE; Vermeer, SE, 2003) |
| "The accumulation of D-isomers of aspartic acid (D-Asp) in proteins during aging has been implicated in the pathogenesis of Alzheimer's disease, cataracts, and arteriosclerosis." | 3.72 | Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging. ( Hamamoto, T; Ikeda, M; Ishiura, S; Kagawa, Y; Kawahara, H; Kinouchi, T; Mabuchi, Y; Matsui, H; Nishio, H; Nishiuchi, Y; Suzuki, K; Takada, K; Tomioka, S; Tsunemi, M; Urakami-Manaka, Y; Watanabe, M, 2004) |
| "Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter." | 3.72 | Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004) |
| "The effect of K and Mg salts of aspartic acid (Cardilan) on the serum concentration of selected proteins and phagocytic activity in aging male Wistar rats was investigated." | 3.71 | Effect of K, MG aspartate on some biological parameters of aging rats. ( Ahlers, I; Ahlersová, E; Bacenková, D; Chlebovská, K; Chlebovskỳ, O, 2002) |
| "The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system." | 3.70 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| " In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vivo neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE)." | 3.69 | Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study. ( Bachevalier, J; Bertolino, A; Frank, JA; Mattay, VS; Saunders, RC; Weinberger, DR, 1997) |
| "To investigate the role of glutamic (Glu) and aspartic acid (Asp) in migraine, we measured the plasma amino acids in migraine patients with and without aura, between and during attacks, and compared the profiles with the plasma amino acid profiles of tension headache patients and healthy controls." | 3.68 | Neuroexcitatory plasma amino acids are elevated in migraine. ( Bos, KD; Bruyn, GW; Ferrari, MD; Malessy, MJ; Odink, J, 1990) |
| "Twenty-seven patients with cervical spondylosis were evaluated." | 2.80 | Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy. ( Ellingson, BM; Hardy, AJ; Holly, LT; Salamon, N, 2015) |
| "NAA/choline ratios were significantly reduced (P<0." | 2.71 | Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. ( Aleman, A; de Haan, EH; de Vries, R; de Winter, CF; Drent, ML; Kenemans, JL; Koppeschaar, HP; Lijffijt, M; van Dam, PS; van der Grond, J, 2005) |
| "Therefore, effective treatments for aging have not yet been developed, and the establishment of therapeutic strategies has not progressed accordingly." | 1.72 | N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice. ( Izuo, N; Kitazawa, A; Miyanishi, H; Muramatsu, SI; Nitta, A, 2022) |
| "Cataract is the leading cause of visual impairment globally." | 1.62 | Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin. ( He, WW; Lu, Y; Qi, J; Zhang, KK; Zhu, XJ, 2021) |
| "Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development." | 1.38 | Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. ( Abe, O; Aoki, Y; Gonoi, W; Inoue, H; Iwashiro, N; Kasai, K; Kato, N; Katsura, M; Kawakubo, Y; Kunimatsu, A; Kuwabara, H; Matsuzaki, H; Murakami, M; Natsubori, T; Nippashi, Y; Sasaki, H; Takano, Y; Takao, H; Tsuchiya, KJ; Yahata, N; Yamasue, H, 2012) |
| "Twenty-four patients with spastic diplegia and twenty-six healthy children were examined." | 1.35 | An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study. ( Kubas, B; Kulak, W; Otapowicz, D; Smigielska-Kuzia, J; Sobaniec, W; Zawada, B, 2009) |
| "Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects." | 1.35 | Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009) |
| "The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)." | 1.33 | Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006) |
| "Elastin was purified in a multistep procedure designed to remove contaminating proteins and to avoid induced racemization." | 1.32 | Aspartic acid racemization: evidence for marked longevity of elastin in human skin. ( Collins, MJ; Laumeier, I; Ritz-Timme, S, 2003) |
| "We have studied the effect of age as well as the effect of short-term and long-term intake of K and Mg salts of aspartic acid (Cardilan) on haemopoiesis in ICR mice strain." | 1.31 | Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis. ( Chlebovský, O; Fedorocko, P; Macková, NO; Sándorcínová, Z; Sedláková-Hoferová, Z; Solár, P, 2000) |
| "Cadmium treatment of adult animals caused a decrease in glutamine content, as compared to controls." | 1.31 | Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats. ( Esquifino, AI; Fenández-Rey, E; Lafuente, A; Pérez-Lorenzo, M; Seara, R, 2001) |
| "D-Aspartic acid was detected in all the brain tissue samples tested, but at different levels." | 1.31 | Determination of free aspartic acid enantiomers in rat brain by capillary electrophoresis with laser-induced fluorescence detection. ( Feng, Y; LeBlanc, MH; Liu, YM; Zhao, S, 2001) |
| "The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)." | 1.31 | Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001) |
| "Glycine and taurine were present at relatively low concentrations during the prenatal period, then rose significantly by about 4-fold after birth; their levels decreased by the end of the first postnatal week but increased gradually thereafter until reaching adult values by the third week." | 1.30 | Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures. ( Benítez-Diaz, PR; Delgado-Saez, MC; Mendoza-Briceño, RV; Miranda-Contreras, L; Palacios-Prü, EL, 1999) |
| "[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats." | 1.30 | Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997) |
| "The glycine effect was strychnine-insensitive, characteristic of the glycine modulatory site in the N-methyl-D-aspartate receptor." | 1.29 | Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice. ( Oja, SS; Saransaari, P, 1994) |
| "Choline was high at birth and declined thereafter." | 1.28 | In vivo 1H and 31P NMR spectroscopy of the developing rat brain. ( Hida, K; Kwee, IL; Nakada, T, 1992) |
| "1." | 1.28 | Anoxia on slow inward currents of immature hippocampal neurons. ( Ben-Ari, Y; Cherubini, E; Krnjević, K, 1989) |
| " Thus, even very moderate Asp dosing causes marked increases in CVO Asp." | 1.27 | Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain. ( Buchsbaum, S; Crow, SE; Lowry, OH; Olney, JW; Price, MT; Pusateri, ME, 1984) |
| " The implications of these results are that, in slices, cellular uptake is responsible for (i) the dose-response curves to L-glutamate, L- and D-aspartate bearing little or no relationship to the true (or relative) potencies of these amino acids; (ii) the potency of APV towards the actions of transported agonists acting at NMDA receptors being reduced and (iii) a differential sensitivity to APV of responses to L-glutamate and L-aspartate being created, the consequence being that a potent action of L-glutamate on NMDA receptors is disguised." | 1.27 | Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices. ( Garthwaite, J, 1985) |
| " Dose-response curves revealed that adult animals were more than 10-fold less sensitive to NMDA than their younger counterparts." | 1.27 | Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat. ( Bell, RD; Cicero, TJ; Meyer, ER, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 92 (24.60) | 18.7374 |
| 1990's | 102 (27.27) | 18.2507 |
| 2000's | 89 (23.80) | 29.6817 |
| 2010's | 76 (20.32) | 24.3611 |
| 2020's | 15 (4.01) | 2.80 |
| Authors | Studies |
|---|---|
| Hone-Blanchet, A | 1 |
| Bohsali, A | 1 |
| Krishnamurthy, LC | 1 |
| Shahid, S | 1 |
| Lin, Q | 1 |
| Zhao, L | 1 |
| Loring, D | 1 |
| Goldstein, F | 1 |
| John, SE | 1 |
| Fleischer, CC | 1 |
| Levey, A | 1 |
| Lah, J | 1 |
| Qiu, D | 1 |
| Crosson, B | 1 |
| Miyanishi, H | 1 |
| Kitazawa, A | 1 |
| Izuo, N | 1 |
| Muramatsu, SI | 1 |
| Nitta, A | 1 |
| Castro, A | 1 |
| Signini, ÉF | 1 |
| De Oliveira, JM | 1 |
| Di Medeiros Leal, MCB | 1 |
| Rehder-Santos, P | 1 |
| Millan-Mattos, JC | 1 |
| Minatel, V | 1 |
| Pantoni, CBF | 1 |
| Oliveira, RV | 1 |
| Catai, AM | 1 |
| Ferreira, AG | 1 |
| Rodríguez-Nieto, G | 1 |
| Levin, O | 2 |
| Hermans, L | 1 |
| Weerasekera, A | 1 |
| Sava, AC | 1 |
| Haghebaert, A | 1 |
| Huybrechts, A | 1 |
| Cuypers, K | 1 |
| Mantini, D | 1 |
| Himmelreich, U | 2 |
| Swinnen, SP | 1 |
| Vints, WAJ | 1 |
| Ziv, G | 1 |
| Katkutė, G | 1 |
| Kušleikienė, S | 1 |
| Valatkevičienė, K | 1 |
| Sheoran, S | 1 |
| Drozdova-Statkevičienė, M | 1 |
| Gleiznienė, R | 1 |
| Pääsuke, M | 1 |
| Dudonienė, V | 1 |
| Česnaitienė, VJ | 1 |
| Masiulis, N | 1 |
| Mahmoudi, N | 1 |
| Dadak, M | 1 |
| Bronzlik, P | 2 |
| Maudsley, AA | 4 |
| Sheriff, S | 2 |
| Lanfermann, H | 2 |
| Ding, XQ | 2 |
| Raspa, M | 1 |
| Paoletti, R | 1 |
| Mahabir, E | 1 |
| Scavizzi, F | 1 |
| Ha, S | 1 |
| Kinouchi, T | 2 |
| Fujii, N | 28 |
| Deelchand, DK | 3 |
| McCarten, JR | 2 |
| Hemmy, LS | 2 |
| Auerbach, EJ | 1 |
| Eberly, LE | 1 |
| Marjańska, M | 3 |
| Luo, HH | 1 |
| Feng, XF | 1 |
| Yang, XL | 1 |
| Hou, RQ | 1 |
| Fang, ZZ | 1 |
| Pigolkin, YI | 1 |
| Selyanina, KP | 1 |
| Velenko, PS | 1 |
| Magami, K | 1 |
| Hachiya, N | 1 |
| Morikawa, K | 1 |
| Takata, T | 8 |
| Davydova, TV | 2 |
| Gruden, MA | 2 |
| Kudrin, VS | 2 |
| Narkevich, VB | 2 |
| Vetrile, LA | 2 |
| Zakharova, IA | 2 |
| Sewell, RDE | 2 |
| Zhu, XJ | 1 |
| Zhang, KK | 1 |
| He, WW | 1 |
| Qi, J | 1 |
| Lu, Y | 1 |
| Hodges, J | 1 |
| Grant, A | 1 |
| Terpstra, M | 2 |
| Godfrey, DA | 1 |
| Chen, K | 1 |
| O'Toole, TR | 1 |
| Mustapha, AIAA | 1 |
| Engeroff, T | 1 |
| Vogt, L | 1 |
| Fleckenstein, J | 1 |
| Füzéki, E | 1 |
| Matura, S | 1 |
| Pilatus, U | 1 |
| Schwarz, S | 1 |
| Deichmann, R | 1 |
| Hellweg, R | 1 |
| Pantel, J | 1 |
| Banzer, W | 1 |
| Aki, K | 3 |
| Sakaue, H | 1 |
| Murakami, K | 1 |
| Toyama, A | 1 |
| Nakamura-Hirota, T | 1 |
| Inoue, R | 1 |
| Morishima, K | 1 |
| Sato, N | 1 |
| Sugiyama, M | 1 |
| Mellen, EJ | 1 |
| Harper, DG | 1 |
| Ravichandran, C | 1 |
| Jensen, E | 1 |
| Silveri, M | 1 |
| Forester, BP | 1 |
| Sporn, L | 1 |
| MacMillan, EL | 1 |
| Ge, R | 1 |
| Greenway, K | 1 |
| Vila-Rodriguez, F | 1 |
| Laule, C | 1 |
| Fried, PJ | 1 |
| Pascual-Leone, A | 1 |
| Bolo, NR | 1 |
| Liu, T | 1 |
| Li, Z | 1 |
| He, J | 1 |
| Yang, N | 1 |
| Han, D | 1 |
| Li, Y | 2 |
| Tian, X | 1 |
| Liu, H | 1 |
| Manyande, A | 1 |
| Xiang, H | 1 |
| Xu, F | 1 |
| Wang, J | 1 |
| Guo, X | 1 |
| Swiatkowski, P | 1 |
| Sesti, F | 1 |
| Hädel, S | 1 |
| Wirth, C | 1 |
| Rapp, M | 1 |
| Gallinat, J | 1 |
| Schubert, F | 1 |
| Menezes, TL | 1 |
| Andrade-Valença, LP | 1 |
| Valença, MM | 1 |
| Profant, O | 1 |
| Balogová, Z | 1 |
| Dezortová, M | 1 |
| Wagnerová, D | 1 |
| Hájek, M | 1 |
| Syka, J | 1 |
| Chiu, PW | 1 |
| Mak, HK | 1 |
| Yau, KK | 1 |
| Chan, Q | 1 |
| Chang, RC | 1 |
| Chu, LW | 1 |
| Aoki, Y | 2 |
| Inokuchi, R | 1 |
| Suwa, H | 1 |
| Aoki, A | 1 |
| De Beaumont, L | 1 |
| Tremblay, S | 1 |
| Henry, LC | 1 |
| Poirier, J | 1 |
| Lassonde, M | 1 |
| Théoret, H | 1 |
| Mori, T | 1 |
| Mori, K | 1 |
| Ito, H | 1 |
| Goji, A | 1 |
| Miyazaki, M | 1 |
| Harada, M | 4 |
| Kurosawa, K | 1 |
| Kagami, S | 1 |
| Emir, UE | 1 |
| Lalande, J | 1 |
| Halley, H | 1 |
| Balayssac, S | 1 |
| Gilard, V | 1 |
| Déjean, S | 1 |
| Martino, R | 1 |
| Francés, B | 1 |
| Lassalle, JM | 1 |
| Malet-Martino, M | 1 |
| Matzenauer, C | 2 |
| Reckert, A | 2 |
| Ritz-Timme, S | 8 |
| Choi, IY | 2 |
| Lee, P | 2 |
| Wang, WT | 1 |
| Hui, D | 1 |
| Wang, X | 2 |
| Brooks, WM | 4 |
| Michaelis, EK | 1 |
| Ono, K | 1 |
| Kitagawa, M | 1 |
| Ito, D | 1 |
| Tanaka, N | 2 |
| Watari, T | 1 |
| Harris, JL | 1 |
| Yeh, HW | 1 |
| Swerdlow, RH | 1 |
| Mato Abad, V | 1 |
| Quirós, A | 1 |
| García-Álvarez, R | 1 |
| Loureiro, JP | 1 |
| Alvarez-Linera, J | 1 |
| Frank, A | 1 |
| Hernández-Tamames, JA | 1 |
| Abdel-Aziz, K | 1 |
| Solanky, BS | 1 |
| Yiannakas, MC | 1 |
| Altmann, DR | 1 |
| Wheeler-Kingshott, CA | 1 |
| Thompson, AJ | 2 |
| Ciccarelli, O | 1 |
| Erickson, KI | 1 |
| Leckie, RL | 1 |
| Weinstein, AM | 1 |
| Radchenkova, P | 1 |
| Sutton, BP | 1 |
| Prakash, RS | 1 |
| Voss, MW | 1 |
| Chaddock-Heyman, L | 1 |
| McAuley, E | 1 |
| Kramer, AF | 1 |
| Mazgaj, R | 1 |
| Tal, A | 1 |
| Goetz, R | 1 |
| Lazar, M | 1 |
| Rothman, K | 1 |
| Messinger, JW | 1 |
| Malaspina, D | 1 |
| Gonen, O | 4 |
| Yang, ZY | 1 |
| Yue, Q | 1 |
| Xing, HY | 1 |
| Tan, QY | 1 |
| Sun, HQ | 1 |
| Gong, QY | 1 |
| Tan, ZJ | 1 |
| Quan, H | 1 |
| Clark-Matott, J | 1 |
| Saleem, A | 1 |
| Dai, Y | 1 |
| Shurubor, Y | 1 |
| Ma, X | 1 |
| Safdar, A | 1 |
| Beal, MF | 3 |
| Tarnopolsky, M | 1 |
| Simon, DK | 1 |
| Klumb, K | 1 |
| Lehmann, K | 1 |
| Ellingson, BM | 1 |
| Salamon, N | 1 |
| Hardy, AJ | 1 |
| Holly, LT | 1 |
| Warmack, RA | 1 |
| Mansilla, E | 1 |
| Goya, RG | 1 |
| Clarke, SG | 1 |
| Hao, P | 1 |
| Adav, SS | 1 |
| Gallart-Palau, X | 1 |
| Sze, SK | 1 |
| Sako, W | 1 |
| Abe, T | 1 |
| Izumi, Y | 1 |
| Kaji, R | 1 |
| Brandt, AS | 1 |
| Unschuld, PG | 2 |
| Pradhan, S | 1 |
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| Churchill, G | 1 |
| Harris, AD | 1 |
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| Ross, CA | 1 |
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| Patay, Z | 1 |
| Friedrich, MG | 1 |
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| Raftery, MJ | 2 |
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| Schreiner, SJ | 1 |
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| Wyss, M | 1 |
| Van Bergen, JMG | 1 |
| Quevenco, FC | 1 |
| Steininger, SC | 1 |
| Griffith, EY | 1 |
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| Brickman, AM | 1 |
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| Pruessmann, KP | 1 |
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| Hsueh, MF | 1 |
| Ranganath, LR | 1 |
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| Huebner, JL | 1 |
| Catterall, JB | 1 |
| Kraus, VB | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 3 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180] | 70 participants | Observational | 2003-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for aspartic acid and Aging
| Article | Year |
|---|---|
D-Amino acids in protein: The mirror of life as a molecular index of aging.
Topics: Aging; Aspartic Acid; Chromatography, Liquid; Humans; Proteins; Stereoisomerism; Tandem Mass Spectro | 2018 |
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis.
Topics: Age Factors; Aging; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Humans; Magnetic R | 2013 |
Isomerization of aspartyl residues in crystallins and its influence upon cataract.
Topics: Aging; Amino Acid Sequence; Animals; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens, | 2016 |
Recent advances in mass spectrometric analysis of protein deamidation.
Topics: Aging; Aspartic Acid; Databases, Protein; Humans; Mass Spectrometry; Neurodegenerative Diseases; Pep | 2017 |
Conversion of brain cytosol profile from fetal to adult type during the perinatal period: taurine-NAA exchange.
Topics: Adult; Aging; Animals; Aspartic Acid; Brain; Cytosol; Fetus; Humans; Magnetic Resonance Spectroscopy | 2010 |
Molecular pathology and age estimation.
Topics: Age Determination by Teeth; Aging; Aspartic Acid; Bone and Bones; Dental Enamel; Dentin; DNA, Mitoch | 2010 |
D-amino acid in elderly tissues.
Topics: Aged; Aging; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Crystallins; | 2005 |
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
Topics: Aging; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Humans; Mice; Mice, Knockout | 2006 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Nonenzymatic posttranslational protein modifications in ageing.
Topics: Aging; Asparagine; Aspartic Acid; Deamination; Glycation End Products, Advanced; Humans; Maillard Re | 2008 |
Trophic actions of GABA on the development of physiologically active GABA receptors.
Topics: Aging; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Hum | 1983 |
[Endogenous free D-aspartate and D-serine in mammals].
Topics: Adrenal Glands; Aging; Animals; Aspartic Acid; Brain; Kidney; Liver; Male; Serine; Testis | 1996 |
The mechanisms of simultaneous stereoinversion, racemization, and isomerization at specific aspartyl residues of aged lens proteins.
Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; Isomerism; | 1999 |
Racemization of aspartic acid in human proteins.
Topics: Aging; Amides; Animals; Aspartic Acid; Humans; Proteins; Stereoisomerism | 2002 |
Molecular clocks, molecular profiles, and optimum diets: three approaches to the problem of aging.
Topics: Adult; Aging; Amides; Amines; Animals; Ascorbic Acid; Aspartic Acid; Biological Clocks; Diet; Humans | 1979 |
Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review.
Topics: Aging; Amides; Amino Acids; Animals; Asparagine; Aspartic Acid; Glutamine; Half-Life; Isomerism; Mod | 1979 |
Excitotoxin-mediated neuron death in youth and old age.
Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases, Metabolic; Brain Inju | 1990 |
Isozymes of aspartate aminotransferase in tissues and blood of man.
Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; B | 1966 |
Maturational changes in amino acids in CNS of different mammalian species.
Topics: Aging; Amino Acids; Amino Alcohols; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Cats; D | 1968 |
Effects of diet and stages of development on intestinal cells and enzymes.
Topics: Aging; Aminohydrolases; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Aspar | 1971 |
8 trials available for aspartic acid and Aging
| Article | Year |
|---|---|
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Choline; Creatinine; Diffusion Tensor Imaging; Female; Gait Disor | 2015 |
The aging hippocampus: cognitive, biochemical and structural findings.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Choline; Cognition; Creatine; Female; Hippocam | 2003 |
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate.
Topics: Adolescent; Adult; Age of Onset; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; C | 2005 |
Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame.
Topics: Aging; Analysis of Variance; Aspartame; Aspartic Acid; Child; Child Behavior; Child, Preschool; Cogn | 1995 |
Proton spectroscopy of human brain: effects of age and sex.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnet | 1994 |
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Respo | 1996 |
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A | 2001 |
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female | 2001 |
346 other studies available for aspartic acid and Aging
| Article | Year |
|---|---|
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Fem | 2022 |
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice.
Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Cognition; Cognitive Dysfunction; Hippocampus; Mi | 2022 |
The Aging Process: A Metabolomics Perspective.
Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Female; Humans; Isoleucine; Leucine; Male; Metabolome | 2022 |
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor | 2023 |
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P | 2023 |
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet | 2023 |
d-aspartate treatment in vitro improves mouse sperm fertility in young B6N mice.
Topics: Acrosome Reaction; Aging; Animals; Aspartic Acid; Cryopreservation; Embryo Transfer; Embryo, Mammali | 2020 |
Age-related isomerization of Asp in human immunoglobulin G kappa chain.
Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Cataract; Chromatography, Liquid; Humans; Immunoglobu | 2020 |
Changes in the intracellular microenvironment in the aging human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M | 2020 |
Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk.
Topics: Adolescent; Adult; Aging; Asian People; Asparagine; Aspartic Acid; China; Diabetes Mellitus, Type 2; | 2020 |
[Comparative assessment of technical approaches to estimating the biological age of a person using chromatographic analysis of dentin].
Topics: Age Determination by Teeth; Aging; Aspartic Acid; Dentin; Humans; Russia | 2021 |
Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide.
Topics: Aging; Alanine; alpha-Crystallin A Chain; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Asp | 2021 |
Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.
Topics: Aging; Animals; Aspartic Acid; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL | 2021 |
Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin.
Topics: Aged; Aging; Aspartic Acid; Cataract; Cell Nucleus; Crystallins; Female; Humans; Isomerism; Lens, Cr | 2021 |
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using
Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Creatine; Dipeptides; | 2017 |
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats.
Topics: Acetylcholine; Age Factors; Aging; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Brain; Ch | 2017 |
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Attention; Brain; Brain-Derived Neurotro | 2019 |
Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens.
Topics: Aged; Aging; Aspartic Acid; beta-Crystallin B Chain; Chromatography, High Pressure Liquid; Chromatog | 2018 |
Asp 58 modulates lens αA-crystallin oligomer formation and chaperone function.
Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Animals; Aspartic Acid; beta-Crystallins; Cattl | 2018 |
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
Topics: Administration, Intranasal; Aging; Animals; Antibodies; Aspartic Acid; Avoidance Learning; Condition | 2019 |
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Cre | 2019 |
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; | 2019 |
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; F | 2020 |
Kinetics of isomerization and inversion of aspartate 58 of αA-crystallin peptide mimics under physiological conditions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Child; C | 2013 |
Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Caenorhabditis elegans; Caenorhabditis elegans Pro | 2013 |
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Audiometry, Pure-Tone; Auditory Cortex; Case-Control Studies; Fem | 2013 |
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem | 2014 |
Motor system alterations in retired former athletes: the role of aging and concussion history.
Topics: Age Factors; Aged; Aging; Analysis of Variance; Apolipoproteins E; Aspartic Acid; Brain; Brain Concu | 2013 |
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glu | 2014 |
Faster metabolite (1)H transverse relaxation in the elder human brain.
Topics: Adolescent; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cellular Microenvironment; Choline; Creat | 2013 |
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebe | 2014 |
Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Elastin; Epiglottis; Forensic Path | 2014 |
Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Glutamate Dehydrogenase; Glutamic Acid; Hippocampus; | 2014 |
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Female; Lactic Acid; Magnetic Resonan | 2014 |
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.
Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Functional Neuroimaging; Glucose; Glutamic Acid; Magn | 2014 |
The partial volume effect in the quantification of 1H magnetic resonance spectroscopy in Alzheimer's disease and aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Cogni | 2014 |
Age related changes in metabolite concentrations in the normal spinal cord.
Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; | 2014 |
Education mitigates age-related decline in N-Acetylaspartate levels.
Topics: Aged; Aging; Aspartic Acid; Cognitive Reserve; Educational Status; Female; Frontal Lobe; Humans; Mag | 2015 |
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc | 2016 |
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glu | 2015 |
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Aspartic Acid; Brain; Carnitine; DNA Damage; DNA Polyme | 2015 |
Age estimation based on aspartic acid racemization in human sclera.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Chromatography, Gas; Female | 2016 |
Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens.
Topics: Age Factors; Aging; Animals; Aspartic Acid; Biomarkers; Chromatography, High Pressure Liquid; Eye Pr | 2016 |
Isomerization of Asp residues plays an important role in αA-crystallin dissociation.
Topics: Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract; Chromatogr | 2016 |
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional S | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Physiological neuronal decline in healthy aging human brain - An in vivo study with MRI and short echo-time whole-brain (1)H MR spectroscopic imaging.
Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Imaging; Ma | 2016 |
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child, | 2016 |
Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?
Topics: Adult; Aged; Aging; Arginine; Aspartic Acid; Cerebellum; Glutamine; Humans; Isoaspartic Acid; Mass S | 2016 |
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a
Topics: Aged; Aging; Aspartic Acid; Energy Metabolism; Female; Gray Matter; Gyrus Cinguli; Humans; Magnetic | 2016 |
Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alkaptonuria; Aspartic Acid; Biomarkers; Cartilage Oligomeric | 2017 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants?
Topics: Aging; Aspartic Acid; Basal Ganglia; Child Development; Choline; Cohort Studies; Follow-Up Studies; | 2008 |
Oxidative stress as regulatory factor for fatty-acid-induced uncoupling involving liver mitochondrial ADP/ATP and aspartate/glutamate antiporters of old rats.
Topics: Aging; Amino Acid Transport System X-AG; Animals; Antioxidants; Antiporters; Aspartic Acid; Atractyl | 2008 |
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats.
Topics: Aging; Alprostadil; Animals; Aspartic Acid; Drug Delivery Systems; Estrogens; Female; Fluorescein-5- | 2008 |
Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spec | 2008 |
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.
Topics: Adolescent; Aging; Aspartic Acid; Basal Ganglia; Case-Control Studies; Cerebral Palsy; Child; Child, | 2009 |
Brain flexibility and balance and gait performances mark morphological and metabolic abnormalities in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Community Health Planning; Creatine; | 2008 |
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor | 2008 |
Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Biological Transport; Bumetanide; Cells, Cultured; Centra | 2009 |
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschoo | 2009 |
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Copper deficiency alters the neurochemical profile of developing rat brain.
Topics: Aging; Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Cerebellum; Citric Acid; Coppe | 2009 |
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co | 2011 |
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Glucose Tolerance Test; Glutamic | 2010 |
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationsh | 2010 |
Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aorta, Abdominal; Arteriosclerosis; Aspartic Acid | 2010 |
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
Topics: Adolescent; Age Factors; Aging; Anisotropy; Aspartic Acid; Axons; Biomarkers; Brain Injuries; Child; | 2010 |
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe | 2010 |
Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging.
Topics: Aging; Animals; Aspartic Acid; Biomarkers; Collagen Type I; Female; Horses; Male; Tendon Injuries; T | 2010 |
Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.
Topics: Aging; Animals; Aspartic Acid; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporte | 2010 |
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA | 2010 |
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch | 2010 |
Age-dependent remodelling of ionotropic signalling in cortical astroglia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acid Transport System X-AG; Animals; Aspartic Aci | 2011 |
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine; | 2012 |
Age-related changes of serum N-acetyl-aspartate in healthy controls.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Pr | 2011 |
[Normal aging and imaging correlations].
Topics: Aging; Aspartic Acid; Brain; Humans; Magnetic Resonance Imaging; Reference Values; Statistics as Top | 2011 |
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies; | 2012 |
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonan | 2012 |
Estimation of chronological age from the racemization rate of L- and D-aspartic acid: how to completely separate enantiomers from dentin.
Topics: Aging; Animals; Aspartic Acid; Dentin; Humans; Stereoisomerism | 2012 |
Daydreaming about our metaphorical tool belt.
Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male | 2012 |
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu | 2012 |
Whole brain N-acetylaspartate concentration is conserved throughout normal aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Atrophy; Biomarkers; Brain; Brain Chemistry; F | 2012 |
Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Isomerases; Aspartic Acid; Autopsy; Elastin; Femal | 2012 |
Structural features of isomerizable aspartyl residues in human α-crystallins.
Topics: Aging; alpha-Crystallin A Chain; alpha-Crystallin B Chain; Amino Acid Sequence; Aspartic Acid; Cloni | 2012 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senesce | 2012 |
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Humans; Magnetic Res | 2012 |
Accelerated aging of Asp 58 in αA crystallin and human cataract formation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract | 2013 |
Age-modulated association between prefrontal NAA and the BDNF gene.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Brain-Derived Neurotrophic Factor; Depression; Depressive D | 2013 |
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; | 2013 |
Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Aspartic Acid; Female; Hippocampus; Male; Motor Activ | 2002 |
Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Linear Mode | 2003 |
Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Elastin; Forensic Medicine; Human | 2003 |
Age-related apoptotic dysfunction: any role for polypeptide aspartate instability?
Topics: Aging; Apoptosis; Aspartic Acid; Humans; Peptides; Phenotype | 2003 |
Memory training alters hippocampal neurochemistry in healthy elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Cortex; Chol | 2003 |
Electrolyte and amino acid changes in rat brain during maturation.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Chlorides; Glutamates; Glutamine; Nitrogen; Potas | 1962 |
[N-ACETYL-ASPARTIC ACID IN NERVE TISSUE. QUANTITATIVE CHANGES IN THE BRAIN OF GROWING ANIMALS].
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Nerve Tissue; Poultry; Rats; Research | 1963 |
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; | 1964 |
COMPARTMENTATION OF GLUTAMIC ACID METABOLISM IN DEVELOPING CEREBRAL CORTEX.
Topics: Aging; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartic Acid; Brain Chemistry; Cats; | 1965 |
METABOLISM OF PROPIONATE BY SHEEP LIVER. INTERRELATIONS OF PROPIONATE AND GLUTAMATE IN AGED MITOCHONDRIA.
Topics: Acyl Coenzyme A; Aging; Amino Acids; Animals; Aspartic Acid; Carbon Dioxide; Citrates; Fatty Acids; | 1965 |
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female; | 2003 |
Aspartic acid racemization: evidence for marked longevity of elastin in human skin.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Aspartic Acid; Child; Child, Prescho | 2003 |
Protein L-isoaspartyl methyltransferase repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration.
Topics: Aging; Animals; Aspartic Acid; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Dros | 2004 |
Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.
Topics: Aging; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Caenorhabditis elegans; Cysteine Endope | 2004 |
Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats.
Topics: Aging; alpha-Crystallin A Chain; Animals; Aspartic Acid; Cataract; Disease Models, Animal; Humans; I | 2004 |
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal | 2004 |
Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.
Topics: Aging; Animals; Aspartic Acid; Caloric Restriction; Citric Acid; Citric Acid Cycle; Glutamic Acid; K | 2004 |
Kinetic study of racemization of aspartyl residues in synthetic elastin peptides.
Topics: Aging; Amino Acids; Aspartic Acid; Elastin; Exons; Humans; Isomerism; Kinetics; Peptides; Skin; Temp | 2004 |
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
Topics: Adult; Aging; Alleles; Asian People; Aspartic Acid; Cell Cycle Proteins; Chromatography, High Pressu | 2004 |
Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Attention; Brain Chemistry; Ch | 2004 |
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydrox | 2005 |
Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T.
Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Chemistry; Creatine; Female; Glutamic | 2005 |
Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy.
Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; H | 2005 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; | 2005 |
MRS of normal and impaired fetal brain development.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric | 2006 |
Novel chiral selectors anchored on polydimethylsiloxane as stationary phases for separation of derivatized amino acid enantiomers by capillary gas chromatography.
Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Chromatography, Gas; Dentin; Dimethylpolysiloxanes; | 2006 |
Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Aspartic Acid; Biomarkers; Child; Chil | 2006 |
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution; | 2006 |
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar | 2006 |
Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy.
Topics: Aging; Algorithms; Aspartic Acid; Brain; Brain Chemistry; Female; Fetal Development; Gestational Age | 2006 |
Age-dependent changes in the racemisation ratio of aspartic acid in human alveolar bone.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; D-Aspartic Acid; Female; Femur; Humans; Male; | 2007 |
An improved sample preparation for an LC method used in the age estimation based on aspartic acid racemization from human dentin.
Topics: Age Factors; Aging; Aspartic Acid; Chromatography, Liquid; Dentin; Humans; Isomerism | 2007 |
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Cognition; Cognition Disorders; Cross-Sectiona | 2007 |
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe | 2007 |
Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Imaging, Th | 2008 |
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema | 2007 |
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr | 2008 |
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Reson | 2008 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats.
Topics: Age Factors; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Female; gamma-Aminobutyric Acid; G | 1980 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Gluta | 1982 |
Age-related changes in the glutamate metabolism of cerebral cortical slices from rats.
Topics: Aging; Animals; Aspartic Acid; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; | 1982 |
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lo | 1982 |
Excitotoxic amino acids as neuroendocrine research tools.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Axons; Blood-Brain Barrier; Brain; Glutamates; Glutamic | 1983 |
Metabolism of the glutamate group of amino acids in rat brain as a function of age.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Energy Metabolism; Enzymes; gamma-Aminob | 1984 |
Investigations of in vivo methionine racemization in mammalian tissues.
Topics: Aging; Animals; Aspartic Acid; Chromatography, Gas; Dentin; Hydrogen-Ion Concentration; Kinetics; Le | 1984 |
Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Hypothalamus; Kinetics; Mice; Mice, Inbr | 1984 |
Stereochemically altered noncollagenous protein from human dentin.
Topics: Aging; Aspartic Acid; Dentin; Humans; Kinetics; Protein Conformation; Proteins; Tooth | 1983 |
Accumulation of D-aspartic acid with age in the human brain.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Eye Proteins; Humans; Lens Nucleus, Crystalline; | 1983 |
Senile cataracts and aging changes in human proteins.
Topics: Aged; Aging; Aspartic Acid; Cataract; Crystallins; Humans; In Vitro Techniques; Molecular Weight; Pr | 1983 |
[In vivo amino acid racemization: possible role in the molecular aging of proteins (author's transl)].
Topics: Aging; Aspartic Acid; Lens, Crystalline; Proteins; Stereoisomerism; Time Factors; Tooth | 1980 |
A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals.
Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Carps; Chickens; Chromatography, Gas; Citrates; Colu | 1981 |
Developmental changes of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid in different brain regions and spinal cords of rat and guinea pig.
Topics: Aging; Animals; Aspartic Acid; Brain; Dipeptides; Glutamates; Guinea Pigs; Organ Specificity; Rats; | 1981 |
Glutamate metabolism in ageing rat brain.
Topics: Acetates; Aging; Animals; Aspartic Acid; Brain; Female; Glucose; Glutamates; Glutamine; Rats | 1980 |
Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Excitatory Amino | 1995 |
Effect of ageing on tissue levels of amino acids involved in the nitric oxide pathway in rat brain.
Topics: Aging; Amino Acid Oxidoreductases; Amino Acids; Animals; Arginine; Aspartic Acid; Brain Chemistry; C | 1993 |
Studies on age estimation using racemization of aspartic acid in cementum.
Topics: Adult; Age Determination by Teeth; Aged; Aged, 80 and over; Aging; Aspartic Acid; Dental Cementum; D | 1995 |
Spontaneous alterations in the covalent structure of synapsin I during in vitro aging.
Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Cattle; Cross-Linking Reagents; Disulfides; Electrop | 1995 |
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies.
Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobut | 1995 |
Glucose deprivation increases aspartic acid release from synaptosomes of aged mice.
Topics: Age Factors; Aging; Animals; Aspartic Acid; Brain; Energy Metabolism; Female; Glucose; Glutamic Acid | 1995 |
Racemization of aspartic acid in human cementum with age.
Topics: Adolescent; Adult; Age Determination by Teeth; Aged; Aged, 80 and over; Aging; Aspartic Acid; Bicusp | 1995 |
Simultaneous stereoinversion and isomerization at specific aspartic acid residues in alpha A-crystallin from human lens.
Topics: Aging; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; Isomerism; Lens, Crystalline; Molecu | 1994 |
Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission.
Topics: Aging; Animals; Aspartic Acid; Brain; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclic | 1994 |
High affinity uptake of glutamate and aspartate in the developing rat retina.
Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Retina; Subcellular Fracti | 1994 |
Enhanced aspartate release related to epilepsy in (EL) mice.
Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca | 1994 |
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Ne | 1994 |
Age-related changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine function.
Topics: 4-Aminobutyrate Transaminase; Acetylcholine; Aging; Animals; Aspartic Acid; Auditory Pathways; Biolo | 1994 |
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; C | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Femal | 1994 |
L-glutamate and L-aspartate concentrations in the developing and aging human putamen tissue.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Female; G | 1993 |
Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.
Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Amino Acids; Aspartic Acid; Crystallins; Humans | 1994 |
The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Magnetic Res | 1993 |
Racemization of aspartic acid in the extracellular matrix proteins of primary and secondary dentin.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Child; Chromatography, Gas; Dentin; Extracellular Matrix Pr | 1993 |
Regulation of intestinal nutrient transport is impaired in aged mice.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Biological Transport; Dietary Carbohydrates; Dietary Pro | 1993 |
Aspartic acid racemization in intervertebral discs as an aid to postmortem estimation of age at death.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Humans; Intervertebral Disc | 1993 |
Embryonic development and postnatal changes in free D-aspartate and D-serine in the human prefrontal cortex.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Chromatog | 1993 |
Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain.
Topics: Aging; Animals; Aspartic Acid; Brain; Female; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Rats | 1995 |
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud | 1996 |
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; | 1996 |
Age estimation in biopsy specimens of dentin.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Biopsy; Child; Dentin; Forensic Dentistry; Germany; H | 1995 |
Changes in D-aspartic acid in human deciduous teeth with age from 1-20 years.
Topics: Adolescent; Aging; Aspartic Acid; Child; Child, Preschool; Dentin; Humans; Infant; Stereoisomerism; | 1996 |
Interaction between anionic amino acids and the mammary tissue (Na(+)-glutamate) cotransporter.
Topics: Aging; Amino Acid Transport System X-AG; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Carrier | 1996 |
The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing.
Topics: Aging; Amphetamine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; Dopamine | 1995 |
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebra | 1996 |
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali | 1996 |
Developmental changes of soluble and membrane-bound aspartate aminopeptidase activities in rat brain.
Topics: Aging; Aminopeptidases; Animals; Aspartic Acid; Brain; Glutamyl Aminopeptidase; Male; Membrane Prote | 1996 |
Estimating NAA in cortical gray matter with applications for measuring changes due to aging.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Female; Humans; Magnetic Resonance Spectroscopy | 1997 |
Identifying monoaminergic, GABAergic, and cholinergic characteristics in immortalized neuronal cell lines.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Cell Line, Transformed; Cell | 1997 |
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpi | 1997 |
Age-related changes of sodium-dependent D-[3H]aspartate and [3H]FK506 binding in rat brain.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Excitatory Amino Acids; Immunosuppressive Age | 1997 |
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat | 1997 |
[Age determination by measurement of the ratio of D- and L- forms of aspartic acid. II. Chiral separation of amino acids from human dentin].
Topics: Age Determination by Teeth; Aging; Aspartic Acid; Chromatography; Dentin; Forensic Medicine; Humans; | 1997 |
[Present possibilities of age determination in forensic medicine with emphasis on the importance of measurement of D- and L- forms of aspartic acid. I. An overview].
Topics: Age Determination by Teeth; Aging; Aspartic Acid; Dentin; Forensic Medicine; Humans; Lens, Crystalli | 1997 |
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hipp | 1997 |
Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain Mapping; Creatine; Energy Metabolism; Female; Frontal Lobe; | 1997 |
Reserpine effects on neurotransmitters in chick heart during growth.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Inj | 1997 |
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Intracranial Arteriosclerosis; Magneti | 1997 |
Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Blotting, Northern; Blotting, Western; Cytochrome P | 1997 |
Neurochemical development of the degenerating rat retina.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; gamma-Aminobutyric Acid; Glu | 1997 |
The conformation formed by the domain after alanine-155 induces inversion of aspartic acid-151 in alpha A-crystallin from aged human lenses.
Topics: Aged; Aged, 80 and over; Aging; Alanine; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; In | 1997 |
Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study.
Topics: Aging; Amygdala; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Choline; Creatine; Entorhinal | 1997 |
Kainate potentiates D-aspartate release from hippocampal slices from developing and ageing mice.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Excitatory Amino Acid Agonists; Female; Hippocampus | 1997 |
Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age.
Topics: Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Animals; Aspartic Acid; Cartilage, Articular; Extr | 1998 |
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippo | 1998 |
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito | 1998 |
Evaluation of aspartic acid racemization ratios in the human femur for age estimation.
Topics: Adolescent; Adult; Age Determination by Skeleton; Aged; Aged, 80 and over; Aging; Aspartic Acid; Chr | 1998 |
In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reso | 1999 |
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Female; | 1999 |
Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.
Topics: Adenosine; Aging; Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Male; Microdialysis; N | 1999 |
Changes in the amount of D-aspartic acid in the human femur with age.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Female; Femur; Humans; Male | 1998 |
Aging of the adult human brain: in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Humans; Magnet | 1999 |
MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain.
Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Choline; Creatine; | 1999 |
Developmental sex differences in amino acid neurotransmitter levels in hypothalamic and limbic areas of rat brain.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; gamma-Aminobutyric Acid; Gluta | 1999 |
The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antibodies; Aspartic Acid; Autopsy; Biomar | 1999 |
Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Müller cell glutamate transporter GLAST.
Topics: Aging; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-B | 1999 |
1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metab | 1999 |
Favourable effect of K, Mg aspartate on serum proteins in aging rats.
Topics: Aging; Alpha-Globulins; Animals; Aspartic Acid; Blood Protein Electrophoresis; Haptoglobins; Immunoe | 1999 |
Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High P | 1999 |
Evaluation of aspartic acid racemization ratios in the human femur for age estimation.
Topics: Adolescent; Adult; Age Determination by Skeleton; Aged; Aged, 80 and over; Aging; Aspartic Acid; Eva | 1999 |
D-amino acid formation induced by a chiral field within a human lens protein during aging.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Crystallins; Humans; Lens, Crystalline; Models, Chemi | 1999 |
Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells.
Topics: Aging; Animals; Aspartic Acid; Benzothiadiazines; Cerebellum; Dicarboxylic Acids; Electric Stimulati | 1999 |
Formation of four isomers at the asp-151 residue of aged human alphaA-crystallin by natural aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Crystallins; Humans; In Vitro Techniques; Infa | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic | 1999 |
Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.
Topics: Adult; Aged; Aging; Animals; Aspartic Acid; Biomarkers; Bone and Bones; Bone Diseases, Metabolic; Bo | 2000 |
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chloroform; Creatine; gamma-Aminobutyric Acid | 1999 |
Adult and fetal haemoglobin J-Sardegna [alpha50(CE8)His-->Asp]: functional and molecular modelling studies.
Topics: 2,3-Diphosphoglycerate; Adult; Aging; Amino Acid Substitution; Arginine; Aspartic Acid; Binding Site | 2000 |
Age-related changes in the D-aspartic acid content of the teeth of the senescence-accelerated mouse.
Topics: Aging; Animals; Aspartic Acid; Body Temperature; Female; Incisor; Male; Mice; Mice, Inbred Strains; | 2000 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
In vitro high resolution proton magnetic resonance study of human cerebellar development during the period from the fetus to childhood.
Topics: Aging; Amino Acids; Aspartic Acid; Cerebellum; Child; Child, Preschool; Creatinine; Dipeptides; Embr | 1999 |
Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats.
Topics: Adenosine; Age Factors; Aging; Animals; Aspartic Acid; Glutamic Acid; Male; Neostriatum; Neurons; Ne | 2000 |
D-aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release.
Topics: Acetylcholine; Adrenal Glands; Aging; Aminooxyacetic Acid; Animals; Animals, Newborn; Aspartic Acid; | 2000 |
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absor | 2000 |
Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis.
Topics: Aging; Animals; Aspartic Acid; Cells, Cultured; Female; Hematopoiesis; Hematopoietic Stem Cells; Mag | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Cognition; Energy Metabolism; Female; Frontal Lobe; H | 2000 |
Chemical mapping of anxiety in the brain of healthy humans: an in vivo 1H-MRS study on the effects of sex, age, and brain region.
Topics: Adult; Aging; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Female; Frontal Lobe; Humans; Magnetic | 2000 |
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
Topics: Adult; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectrosco | 2001 |
Development and aging of the cerebrum: assessment with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Ch | 2001 |
Neurotransmitter contents in the retina of RCS rat.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; gamma- | 2000 |
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; | 2001 |
A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations.
Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Choline; Creatinine; Frontal Lobe; Humans; M | 2001 |
Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cadmium; Corpus Striatum; Glutamic Acid; Glutamine; Hypo | 2001 |
[Determination of the D-and L-forms of aspartic acid in intervertebral disk tissue as an indicator of age].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Forensic Medicine; Humans; Interve | 2001 |
[Determination of D- and L- forms of aspartic acid in Achilles tendon tissue as an indicator of age].
Topics: Achilles Tendon; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Forensic Medicine | 2001 |
Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Corpus Striatum; Dementia; Female; Frontal L | 2001 |
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio | 2001 |
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex; | 2001 |
Determination of free aspartic acid enantiomers in rat brain by capillary electrophoresis with laser-induced fluorescence detection.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Electrophoresis, Capillary; Lasers; Rats; Sp | 2001 |
Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body.
Topics: Aging; Animals; Antibody Specificity; Aspartic Acid; Axons; Body Patterning; Brain; Cell Size; Excit | 2001 |
Inversion and isomerization of Asp-58 residue in human alphaA-crystallin from normal aged lenses and cataractous lenses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Infant; Isomeri | 2001 |
Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice.
Topics: Aging; Animals; Aspartic Acid; Cognition; Cognition Disorders; Epilepsy; Isomerism; Long-Term Potent | 2001 |
Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats.
Topics: Aging; Aminooxyacetic Acid; Animals; Aspartic Acid; Excitatory Amino Acids; Female; Follicle Stimula | 2002 |
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorder | 2001 |
Effect of K, MG aspartate on some biological parameters of aging rats.
Topics: Aging; Animals; Aspartic Acid; Blood Proteins; Complement C3; Gamma Rays; Haptoglobins; Hemopexin; I | 2002 |
Developmental delay in children: assessment with proton MR spectroscopy.
Topics: Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities; | 2002 |
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St | 2001 |
Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins.
Topics: Age Factors; Aging; Animals; Aspartic Acid; Folic Acid; Folic Acid Deficiency; Isoaspartic Acid; Liv | 2002 |
Possible role of glutamate, aspartate, glutamine, GABA or taurine on cadmium toxicity on the hypothalamic pituitary axis activity in adult male rats.
Topics: Administration, Oral; Aging; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cadmium; gamma-Am | 2002 |
The presence of D-beta-aspartic acid-containing peptides in elastic fibers of sun-damaged skin: a potent marker for ultraviolet-induced skin aging.
Topics: Aged; Aging; Aspartic Acid; Biomarkers; Child; D-Aspartic Acid; Elastic Tissue; Face; Humans; Immuno | 2002 |
Isolation and identification of urinary beta-aspartyl dipeptides and their concentrations in human urine.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dipeptides; Female; Glutamates; Glycine; Human | 1978 |
Neoplastic transformation-linked alterations in adenylosuccinate synthetase activity.
Topics: Aging; Animals; Aspartic Acid; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Inosine N | 1975 |
Glutamine-dependent asparagine synthetase in fetal, adult and neoplastic rat tissues.
Topics: Aging; Animals; Animals, Newborn; Aspartate-Ammonia Ligase; Aspartic Acid; Enzyme Activation; Fetus; | 1975 |
Aspartic acid racemization in heavy molecular weight crystallins and water insoluble protein from normal human lenses and cataracts.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Cataract; Child; Child, Preschool; Crystallins; Human | 1978 |
Rapid method for the assay of 4-aminobutyric acid (GABA), glutamic acid and aspartic acid in brain tissue and subcellular fractions.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, Ion Exchange; Chromatography, | 1979 |
Plasma aspartate levels in rats following administration of monopotassium aspartate via three routes.
Topics: Administration, Oral; Aging; Amino Acids; Animals; Aspartic Acid; Glutamates; Injections, Intraperit | 1979 |
A radiochemical assay for N-acetyl-L-aspartate amidohydrolase (EC 3.5.1.15) and its occurrence in the tissues of the chicken.
Topics: Aging; Amidohydrolases; Animals; Aspartic Acid; Chickens; Kidney; Male; Nervous System; Tissue Distr | 1978 |
On the etiology of aging.
Topics: Aging; Amino Acids; Aspartic Acid; Half-Life; Humans; Isomerism; Phenylalanine; Proteins; Thermodyna | 1977 |
Aspartic acid racemisation in the human lens during ageing and in cataract formation.
Topics: Aging; Aspartic Acid; Cataract; Humans; Lens, Crystalline; Stereoisomerism | 1977 |
Considerations on the role of aspartic acid racemization in the aging process.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dental Enamel; Dentin; Erythrocytes; Humans; M | 1977 |
Aspartic acid racemisation in dentine as a measure of ageing.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Body Temperature; Child; Dental Enamel; Dentin; Human | 1976 |
Metabolism of glutamate and related amino acids in the 10-day-old mouse brain: experiments with labelled acetate and beta-hydroxybutyrate.
Topics: Acetates; Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon Radioisotopes; | 1976 |
Aspartic acid racemization in tooth enamel from living humans.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dental Enamel; Humans; Mathematics; Middle Age | 1975 |
Pyrimidine biosynthesis and its regulation in the developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Azauridine; Bicarbonates; Brain; Female; Fetus; Mal | 1976 |
[3H]D-aspartic acid release in brain slices of adult and aged Fischer 344 rates.
Topics: Aging; Animals; Aspartic Acid; Brain; Calcium Channels; Electric Stimulation; Hippocampus; Kainic Ac | 1992 |
Age-related changes in binding to excitatory amino acid uptake site in temporal cortex of human brain.
Topics: Aging; Amino Acids; Aspartic Acid; Humans; In Vitro Techniques; Infant; Infant, Newborn; Kinetics; R | 1992 |
Age-related changes in binding to excitatory amino acid uptake sites in human cerebellum.
Topics: Aged; Aging; Amino Acids; Aspartic Acid; Autoradiography; Cerebellar Cortex; Cerebellum; Child, Pres | 1992 |
Regional distribution of glutamate and aspartate in adult and old human brain.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Hum | 1992 |
Age-specific development of malate-aspartate shuttle in the liver and kidney of mice.
Topics: Aging; Animals; Aspartate Aminotransferases; Aspartic Acid; Kidney; Liver; Malate Dehydrogenase; Mal | 1992 |
On the accumulation of D-aspartate in elastin and other proteins of the ageing aorta.
Topics: Aged; Aging; Amino Acids; Aorta; Aspartic Acid; Collagen; Elastin; Humans; Male; Middle Aged | 1992 |
Ischemia does not induce the release of excitotoxic amino acids from the hippocampus of newborn rats.
Topics: Aging; Allopurinol; Animals; Animals, Newborn; Aspartic Acid; Brain Ischemia; Free Radicals; Glutama | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; | 1991 |
Characterization of microcarrier cultures of neurons and astrocytes from cerebral cortex and cerebellum.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cerebellum; Cerebral Cortex; Culture Te | 1991 |
In vivo 1H and 31P NMR spectroscopy of the developing rat brain.
Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Hy | 1992 |
Age-dependent deamidation of the major intrinsic polypeptide from lens membranes.
Topics: Aging; Amino Acid Sequence; Animals; Aquaporins; Asparagine; Aspartic Acid; Cattle; Chromatography, | 1991 |
N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development.
Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Injections, Intraventricu | 1991 |
Postnatal development of the excitatory amino acid system in visual cortex of the rat. Changes in uptake and levels of aspartate and glutamate.
Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Visual C | 1990 |
Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1990 |
Neuroexcitatory plasma amino acids are elevated in migraine.
Topics: Adult; Aging; Aspartic Acid; Female; Glutamates; Glutamic Acid; Headache; Humans; Male; Middle Aged; | 1990 |
Brain development: 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Li | 1990 |
Glycine administration decreases hepatic taurine content in mice.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Glycine; Liver; Male; Mice; Myocardium; Taurine; Ti | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co | 1990 |
Changes in excitatory amino acid modulation of phosphoinositide metabolism during development.
Topics: Aging; Animals; Aspartic Acid; Brain; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Phosphati | 1990 |
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; | 1990 |
Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.
Topics: Adenosine Triphosphate; Adolescent; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; F | 1990 |
Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Gonadotro | 1990 |
Age-related changes in uptake and release on L-[3H]noradrenaline in brain slices of senescence accelerated mouse.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; In Vitro Techniques; Male; Mice; Mice, I | 1990 |
Changes in metabolite transport by small intestine and kidney of young and old rats.
Topics: Aging; Animals; Aspartic Acid; Citrates; Citric Acid; Glucose; In Vitro Techniques; Intestine, Small | 1990 |
Site-specific racemization in aging alpha A-crystallin.
Topics: Aging; Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Cr | 1990 |
D-aspartic acid in purified myelin and myelin basic protein.
Topics: Adult; Aged; Aging; Animals; Aspartic Acid; Brain Chemistry; Cattle; Humans; Infant; Middle Aged; Mu | 1986 |
N-methyl-aspartic acid lesions of the arcuate nucleus in adult C57BL/6J mice: a new model for age-related lengthening of the estrous cycle.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Biogenic Monoamines; Body Weight; Es | 1989 |
Whole-cell voltage-clamp recordings in granule cells acutely isolated from hippocampal slices of adult or aged rats.
Topics: Aging; Animals; Aspartic Acid; Calcium; Cell Separation; Cells, Cultured; Electric Stimulation; Hipp | 1989 |
Anoxia on slow inward currents of immature hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium Channels; Electric Conductivity; Hippocampu | 1989 |
Transient increase of NMDA-binding sites in human hippocampus during development.
Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant, | 1989 |
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol | 1989 |
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methyl | 1989 |
Purification and characterization of a protein containing D-aspartic acid in bovine lens.
Topics: Aging; Animals; Aspartic Acid; Cattle; Chromatography; Crystallins; Electrophoresis, Polyacrylamide | 1989 |
Protein carboxyl methyltransferase activity specific for age-modified aspartyl residues in mouse testes and ovaries: evidence for translation during spermiogenesis.
Topics: Aging; Animals; Aspartic Acid; Female; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Ovary | 1989 |
Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Brain Stem; Cerebellar Cortex; Cerebral Cortex; | 1989 |
Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cyclic GMP; Diffusion; Female; Glutamate | 1985 |
Aspartate metabolism in rats during aging.
Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glut | 1985 |
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type.
Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1986 |
[Aspartate aminotransferase activity high affinity (3H) glutamate/(3H) aspartate uptake in rat nervous tissue in postnatal development].
Topics: Aging; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspartic Acid; Autoradiography; Gangl | 1986 |
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid; | 1986 |
Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; gamma-Aminobutyric Acid; Glutamates; Glu | 1988 |
L-aspartate and L-glutamate binding sites in developing normal and 'nervous' mutant mouse cerebellum.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cerebellum; Female; Glutamates; Gl | 1987 |
Transient increased density of NMDA binding sites in the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hip | 1988 |
Racemization of aspartyl residues in proteins from normal and cataractous human lenses: an aging process without involvement in cataract formation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens | 1989 |
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methyla | 1986 |
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Hippocampus; Microinjections; N-Methylaspartate; Neu | 1988 |
Changes in voltage dependence of NMDA currents during development.
Topics: Aging; Animals; Aspartic Acid; Electric Conductivity; Hippocampus; In Vitro Techniques; Membrane Pot | 1988 |
Solvent extraction clean-up for pre-treatment in amino acid analysis by gas chromatography. Application to age estimation from the D/L ratio of aspartic acid in human dentine.
Topics: Adult; Aging; Amino Acids; Aspartic Acid; Chromatography, Gas; Chromatography, Ion Exchange; Dentin; | 1988 |
Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techni | 1988 |
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing | 1988 |
D-aspartic acid in aged mouse skin and lens.
Topics: Aging; Animals; Aspartic Acid; Lens, Crystalline; Mice; Skin; Whole-Body Irradiation | 1987 |
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane P | 1987 |
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Pot | 1986 |
D-amino acid in irradiated and aged mouse.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cataract; Crystallins; Male; Mice; Mice, Inbred Strains; | 1986 |
Characterization of a protein containing D-aspartic acid in aged mouse lens.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Crystallins; Lens, Crystalline; Male; Mice; Mice, Inbred | 1987 |
D-aspartate in human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain; Brain Di | 1987 |
Plasma glutamate concentrations in 1-year-old infants and adults ingesting monosodium L-glutamate in consommé.
Topics: Administration, Oral; Adult; Aging; Aspartic Acid; Erythrocytes; Female; Glutamates; Humans; Infant; | 1986 |
Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: effect of thyroid hormones.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cell Membrane; Kinetics; Osmolar Concent | 1985 |
Regional changes in amino acid content in developing rat brain.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Ch | 1974 |
Properties of heparan sulphate and chondroitin sulphate from young and old human aortae.
Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Aorta, Thoracic; Aspartic Acid; Chondroitin; Chromatogr | 1969 |
Cytomorphometry of developing rat liver and its application to enzymic differentiation.
Topics: Aging; Animals; Aspartic Acid; Cell Count; Female; Glucagon; Glucokinase; Glucosyltransferases; Glyc | 1972 |
Proceedings: Age-dependent interaction of potassium magnesium aspartate during general anesthesia. A contribution to lactate-pyruvate- and ATP-metabolism.
Topics: Adenosine Triphosphate; Adult; Aging; Anesthesia, General; Aspartic Acid; Drug Interactions; Female; | 1974 |
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomyci | 1973 |
Effect of cortisol treatment on free amino acid levels in rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Glycine; Hydrocortisone; Liver; Male; Muscle Pr | 1973 |
Effect of undernutrition on amino acid compartimentation in the developing rat brain.
Topics: Aging; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Body Weight; Brain; Carbon Radioisotopes | 1974 |
Free amino acids in developing rat retina.
Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Di | 1974 |
The metabolism of (14C) glucose by the brains of suckling rats intoxicated with inorganic lead.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Body Weight; Brain; Carbon Radioisotopes; | 1974 |
[Aortic elastin and its variations during senescence and arteriosclerosis].
Topics: Aging; Amino Acids; Animals; Aorta; Arginine; Arteriosclerosis; Aspartic Acid; Cattle; Elastin; Glut | 1970 |
The subunit structure of alpha-crystallin. Isolation and characterization of the S-carboxymethylated acidic subunits from adult and embryonic origin.
Topics: Aging; Alkylation; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Chromatography, Ion | 1969 |
Effects of dietary vitamin B 6 on the utilization of monosodium glutamate by rats.
Topics: Aging; Alanine; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspart | 1972 |
The isolation and partial characterization of age-correlated oligo-deoxyribo-ribonucleotides with covalently linked aspartyl-glutamyl polypeptides.
Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; | 1972 |
Biosynthesis of collagen fibres.
Topics: Aging; Aspartic Acid; Collagen; Galactose; Glucose; Glutamates; Glycoproteins; Lysine; Proline | 1970 |
Composition and formation of the insoluble protein fraction in the ocular lens.
Topics: Aging; Albumins; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Crystallins; Electrophoresis; Huma | 1970 |
Factors affecting incorporation of precursors into body constituents: a review of common sense considerations with glycolipids as examples.
Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebrosides; Galactose; Gangliosides; Glucos | 1970 |
[Nitrogen metabolism in albino rat brain mitochondria during aging].
Topics: Adenosine Diphosphate; Aging; Ammonia; Animals; Aspartic Acid; Brain; Glutamates; Malonates; Mitocho | 1970 |
The uptake of amino acids by particulate fractions from brain.
Topics: Aging; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartic Acid; Biological Transport, | 1969 |
Changes with age in the utilization of glucose carbon in liver and brain.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon; Carbon Isotopes; Centri | 1966 |