Page last updated: 2024-11-08

aspartic acid and Aging

aspartic acid has been researched along with Aging in 374 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment."7.91Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019)
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."7.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."7.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
" However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment."3.91Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019)
" Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale."3.85Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017)
"The quantification of aspartic acid racemization in the proteins of nonmetabolically active tissues can be used as a measure of chronological aging in humans and other long-lived organisms."3.83Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens. ( Clarke, SG; Goya, RG; Mansilla, E; Warmack, RA, 2016)
" We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)."3.76Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010)
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."3.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects."3.74Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007)
"To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men."3.72Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. ( Breteler, MM; den Heijer, T; Hofman, A; Origgi, D; Oudkerk, M; Sijens, PE; Vermeer, SE, 2003)
"The accumulation of D-isomers of aspartic acid (D-Asp) in proteins during aging has been implicated in the pathogenesis of Alzheimer's disease, cataracts, and arteriosclerosis."3.72Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging. ( Hamamoto, T; Ikeda, M; Ishiura, S; Kagawa, Y; Kawahara, H; Kinouchi, T; Mabuchi, Y; Matsui, H; Nishio, H; Nishiuchi, Y; Suzuki, K; Takada, K; Tomioka, S; Tsunemi, M; Urakami-Manaka, Y; Watanabe, M, 2004)
"Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter."3.72Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004)
"The effect of K and Mg salts of aspartic acid (Cardilan) on the serum concentration of selected proteins and phagocytic activity in aging male Wistar rats was investigated."3.71Effect of K, MG aspartate on some biological parameters of aging rats. ( Ahlers, I; Ahlersová, E; Bacenková, D; Chlebovská, K; Chlebovskỳ, O, 2002)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."3.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
" In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vivo neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE)."3.69Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study. ( Bachevalier, J; Bertolino, A; Frank, JA; Mattay, VS; Saunders, RC; Weinberger, DR, 1997)
"To investigate the role of glutamic (Glu) and aspartic acid (Asp) in migraine, we measured the plasma amino acids in migraine patients with and without aura, between and during attacks, and compared the profiles with the plasma amino acid profiles of tension headache patients and healthy controls."3.68Neuroexcitatory plasma amino acids are elevated in migraine. ( Bos, KD; Bruyn, GW; Ferrari, MD; Malessy, MJ; Odink, J, 1990)
"Twenty-seven patients with cervical spondylosis were evaluated."2.80Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy. ( Ellingson, BM; Hardy, AJ; Holly, LT; Salamon, N, 2015)
"NAA/choline ratios were significantly reduced (P<0."2.71Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. ( Aleman, A; de Haan, EH; de Vries, R; de Winter, CF; Drent, ML; Kenemans, JL; Koppeschaar, HP; Lijffijt, M; van Dam, PS; van der Grond, J, 2005)
"Therefore, effective treatments for aging have not yet been developed, and the establishment of therapeutic strategies has not progressed accordingly."1.72N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice. ( Izuo, N; Kitazawa, A; Miyanishi, H; Muramatsu, SI; Nitta, A, 2022)
"Cataract is the leading cause of visual impairment globally."1.62Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin. ( He, WW; Lu, Y; Qi, J; Zhang, KK; Zhu, XJ, 2021)
"Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development."1.38Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. ( Abe, O; Aoki, Y; Gonoi, W; Inoue, H; Iwashiro, N; Kasai, K; Kato, N; Katsura, M; Kawakubo, Y; Kunimatsu, A; Kuwabara, H; Matsuzaki, H; Murakami, M; Natsubori, T; Nippashi, Y; Sasaki, H; Takano, Y; Takao, H; Tsuchiya, KJ; Yahata, N; Yamasue, H, 2012)
"Twenty-four patients with spastic diplegia and twenty-six healthy children were examined."1.35An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study. ( Kubas, B; Kulak, W; Otapowicz, D; Smigielska-Kuzia, J; Sobaniec, W; Zawada, B, 2009)
"Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects."1.35Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009)
"The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)."1.33Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006)
"Elastin was purified in a multistep procedure designed to remove contaminating proteins and to avoid induced racemization."1.32Aspartic acid racemization: evidence for marked longevity of elastin in human skin. ( Collins, MJ; Laumeier, I; Ritz-Timme, S, 2003)
"We have studied the effect of age as well as the effect of short-term and long-term intake of K and Mg salts of aspartic acid (Cardilan) on haemopoiesis in ICR mice strain."1.31Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis. ( Chlebovský, O; Fedorocko, P; Macková, NO; Sándorcínová, Z; Sedláková-Hoferová, Z; Solár, P, 2000)
"Cadmium treatment of adult animals caused a decrease in glutamine content, as compared to controls."1.31Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats. ( Esquifino, AI; Fenández-Rey, E; Lafuente, A; Pérez-Lorenzo, M; Seara, R, 2001)
"D-Aspartic acid was detected in all the brain tissue samples tested, but at different levels."1.31Determination of free aspartic acid enantiomers in rat brain by capillary electrophoresis with laser-induced fluorescence detection. ( Feng, Y; LeBlanc, MH; Liu, YM; Zhao, S, 2001)
"The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)."1.31Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001)
"Glycine and taurine were present at relatively low concentrations during the prenatal period, then rose significantly by about 4-fold after birth; their levels decreased by the end of the first postnatal week but increased gradually thereafter until reaching adult values by the third week."1.30Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures. ( Benítez-Diaz, PR; Delgado-Saez, MC; Mendoza-Briceño, RV; Miranda-Contreras, L; Palacios-Prü, EL, 1999)
"[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats."1.30Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997)
"The glycine effect was strychnine-insensitive, characteristic of the glycine modulatory site in the N-methyl-D-aspartate receptor."1.29Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice. ( Oja, SS; Saransaari, P, 1994)
"Choline was high at birth and declined thereafter."1.28In vivo 1H and 31P NMR spectroscopy of the developing rat brain. ( Hida, K; Kwee, IL; Nakada, T, 1992)
"1."1.28Anoxia on slow inward currents of immature hippocampal neurons. ( Ben-Ari, Y; Cherubini, E; Krnjević, K, 1989)
" Thus, even very moderate Asp dosing causes marked increases in CVO Asp."1.27Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain. ( Buchsbaum, S; Crow, SE; Lowry, OH; Olney, JW; Price, MT; Pusateri, ME, 1984)
" The implications of these results are that, in slices, cellular uptake is responsible for (i) the dose-response curves to L-glutamate, L- and D-aspartate bearing little or no relationship to the true (or relative) potencies of these amino acids; (ii) the potency of APV towards the actions of transported agonists acting at NMDA receptors being reduced and (iii) a differential sensitivity to APV of responses to L-glutamate and L-aspartate being created, the consequence being that a potent action of L-glutamate on NMDA receptors is disguised."1.27Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices. ( Garthwaite, J, 1985)
" Dose-response curves revealed that adult animals were more than 10-fold less sensitive to NMDA than their younger counterparts."1.27Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat. ( Bell, RD; Cicero, TJ; Meyer, ER, 1988)

Research

Studies (374)

TimeframeStudies, this research(%)All Research%
pre-199092 (24.60)18.7374
1990's102 (27.27)18.2507
2000's89 (23.80)29.6817
2010's76 (20.32)24.3611
2020's15 (4.01)2.80

Authors

AuthorsStudies
Hone-Blanchet, A1
Bohsali, A1
Krishnamurthy, LC1
Shahid, S1
Lin, Q1
Zhao, L1
Loring, D1
Goldstein, F1
John, SE1
Fleischer, CC1
Levey, A1
Lah, J1
Qiu, D1
Crosson, B1
Miyanishi, H1
Kitazawa, A1
Izuo, N1
Muramatsu, SI1
Nitta, A1
Castro, A1
Signini, ÉF1
De Oliveira, JM1
Di Medeiros Leal, MCB1
Rehder-Santos, P1
Millan-Mattos, JC1
Minatel, V1
Pantoni, CBF1
Oliveira, RV1
Catai, AM1
Ferreira, AG1
Rodríguez-Nieto, G1
Levin, O2
Hermans, L1
Weerasekera, A1
Sava, AC1
Haghebaert, A1
Huybrechts, A1
Cuypers, K1
Mantini, D1
Himmelreich, U2
Swinnen, SP1
Vints, WAJ1
Ziv, G1
Katkutė, G1
Kušleikienė, S1
Valatkevičienė, K1
Sheoran, S1
Drozdova-Statkevičienė, M1
Gleiznienė, R1
Pääsuke, M1
Dudonienė, V1
Česnaitienė, VJ1
Masiulis, N1
Mahmoudi, N1
Dadak, M1
Bronzlik, P2
Maudsley, AA4
Sheriff, S2
Lanfermann, H2
Ding, XQ2
Raspa, M1
Paoletti, R1
Mahabir, E1
Scavizzi, F1
Ha, S1
Kinouchi, T2
Fujii, N28
Deelchand, DK3
McCarten, JR2
Hemmy, LS2
Auerbach, EJ1
Eberly, LE1
Marjańska, M3
Luo, HH1
Feng, XF1
Yang, XL1
Hou, RQ1
Fang, ZZ1
Pigolkin, YI1
Selyanina, KP1
Velenko, PS1
Magami, K1
Hachiya, N1
Morikawa, K1
Takata, T8
Davydova, TV2
Gruden, MA2
Kudrin, VS2
Narkevich, VB2
Vetrile, LA2
Zakharova, IA2
Sewell, RDE2
Zhu, XJ1
Zhang, KK1
He, WW1
Qi, J1
Lu, Y1
Hodges, J1
Grant, A1
Terpstra, M2
Godfrey, DA1
Chen, K1
O'Toole, TR1
Mustapha, AIAA1
Engeroff, T1
Vogt, L1
Fleckenstein, J1
Füzéki, E1
Matura, S1
Pilatus, U1
Schwarz, S1
Deichmann, R1
Hellweg, R1
Pantel, J1
Banzer, W1
Aki, K3
Sakaue, H1
Murakami, K1
Toyama, A1
Nakamura-Hirota, T1
Inoue, R1
Morishima, K1
Sato, N1
Sugiyama, M1
Mellen, EJ1
Harper, DG1
Ravichandran, C1
Jensen, E1
Silveri, M1
Forester, BP1
Sporn, L1
MacMillan, EL1
Ge, R1
Greenway, K1
Vila-Rodriguez, F1
Laule, C1
Fried, PJ1
Pascual-Leone, A1
Bolo, NR1
Liu, T1
Li, Z1
He, J1
Yang, N1
Han, D1
Li, Y2
Tian, X1
Liu, H1
Manyande, A1
Xiang, H1
Xu, F1
Wang, J1
Guo, X1
Swiatkowski, P1
Sesti, F1
Hädel, S1
Wirth, C1
Rapp, M1
Gallinat, J1
Schubert, F1
Menezes, TL1
Andrade-Valença, LP1
Valença, MM1
Profant, O1
Balogová, Z1
Dezortová, M1
Wagnerová, D1
Hájek, M1
Syka, J1
Chiu, PW1
Mak, HK1
Yau, KK1
Chan, Q1
Chang, RC1
Chu, LW1
Aoki, Y2
Inokuchi, R1
Suwa, H1
Aoki, A1
De Beaumont, L1
Tremblay, S1
Henry, LC1
Poirier, J1
Lassonde, M1
Théoret, H1
Mori, T1
Mori, K1
Ito, H1
Goji, A1
Miyazaki, M1
Harada, M4
Kurosawa, K1
Kagami, S1
Emir, UE1
Lalande, J1
Halley, H1
Balayssac, S1
Gilard, V1
Déjean, S1
Martino, R1
Francés, B1
Lassalle, JM1
Malet-Martino, M1
Matzenauer, C2
Reckert, A2
Ritz-Timme, S8
Choi, IY2
Lee, P2
Wang, WT1
Hui, D1
Wang, X2
Brooks, WM4
Michaelis, EK1
Ono, K1
Kitagawa, M1
Ito, D1
Tanaka, N2
Watari, T1
Harris, JL1
Yeh, HW1
Swerdlow, RH1
Mato Abad, V1
Quirós, A1
García-Álvarez, R1
Loureiro, JP1
Alvarez-Linera, J1
Frank, A1
Hernández-Tamames, JA1
Abdel-Aziz, K1
Solanky, BS1
Yiannakas, MC1
Altmann, DR1
Wheeler-Kingshott, CA1
Thompson, AJ2
Ciccarelli, O1
Erickson, KI1
Leckie, RL1
Weinstein, AM1
Radchenkova, P1
Sutton, BP1
Prakash, RS1
Voss, MW1
Chaddock-Heyman, L1
McAuley, E1
Kramer, AF1
Mazgaj, R1
Tal, A1
Goetz, R1
Lazar, M1
Rothman, K1
Messinger, JW1
Malaspina, D1
Gonen, O4
Yang, ZY1
Yue, Q1
Xing, HY1
Tan, QY1
Sun, HQ1
Gong, QY1
Tan, ZJ1
Quan, H1
Clark-Matott, J1
Saleem, A1
Dai, Y1
Shurubor, Y1
Ma, X1
Safdar, A1
Beal, MF3
Tarnopolsky, M1
Simon, DK1
Klumb, K1
Lehmann, K1
Ellingson, BM1
Salamon, N1
Hardy, AJ1
Holly, LT1
Warmack, RA1
Mansilla, E1
Goya, RG1
Clarke, SG1
Hao, P1
Adav, SS1
Gallart-Palau, X1
Sze, SK1
Sako, W1
Abe, T1
Izumi, Y1
Kaji, R1
Brandt, AS1
Unschuld, PG2
Pradhan, S1
Lim, IA1
Churchill, G1
Harris, AD1
Hua, J1
Barker, PB2
Ross, CA1
van Zijl, PC1
Edden, RA1
Margolis, RL1
Sabati, M1
Schmitz, B1
Schütze, M1
Kahl, KG1
Löbel, U1
Hwang, S1
Edwards, A1
Li, X1
Broniscer, A1
Patay, Z1
Friedrich, MG1
Hancock, SE1
Raftery, MJ2
Truscott, RJ2
Schreiner, SJ1
Kirchner, T1
Wyss, M1
Van Bergen, JMG1
Quevenco, FC1
Steininger, SC1
Griffith, EY1
Meier, I1
Michels, L1
Gietl, AF1
Leh, SE1
Brickman, AM1
Hock, C1
Nitsch, RM1
Pruessmann, KP1
Henning, A1
Taylor, AM1
Hsueh, MF1
Ranganath, LR1
Gallagher, JA1
Dillon, JP1
Huebner, JL1
Catterall, JB1
Kraus, VB1
Kantorová, E1
Poláček, H1
Bittšanský, M3
Baranovičová, E1
Hnilicová, P1
Čierny, D1
Sivák, Š1
Nosáľ, V1
Zeleňák, K1
Kurča, E1
Augustine, EM1
Spielman, DM2
Barnes, PD1
Sutcliffe, TL1
Dermon, JD1
Mirmiran, M1
Clayton, DB1
Ariagno, RL1
Samartsev, VN1
Kozhina, OV1
Miller, SC1
Pan, H1
Wang, D1
Bowman, BM1
Kopecková, P1
Kopecek, J1
Kirov, II2
Fleysher, L1
Fleysher, R1
Patil, V1
Liu, S1
Kulak, W1
Sobaniec, W1
Smigielska-Kuzia, J1
Kubas, B1
Zawada, B1
Otapowicz, D1
Ben Salem, D2
Walker, PM2
Aho, S1
Tavernier, B2
Giroud, M1
Tzourio, C1
Ricolfi, F2
Brunotte, F2
Bejot, Y1
Aho, SL1
Rouaud, O1
Kelly, T1
Kafitz, KW1
Roderigo, C1
Rose, CR1
Horská, A1
Farage, L1
Bibat, G1
Nagae, LM1
Kaufmann, WE1
Naidu, S1
Chen, CS1
Chiang, IC1
Li, CW1
Lin, WC1
Lu, CY1
Hsieh, TJ1
Liu, GC1
Lin, HF1
Kuo, YT1
Oja, SS6
Saransaari, P6
Gybina, AA1
Tkac, I2
Prohaska, JR1
Ronen, I1
Fan, X1
Schettler, S1
Jain, S1
Murray, D1
Kim, DS1
Killiany, R1
Rosene, D1
Boumezbeur, F1
Mason, GF1
de Graaf, RA1
Behar, KL1
Cline, GW1
Shulman, GI1
Rothman, DL1
Petersen, KF1
Nyitrai, G1
Lasztóczi, B1
Kardos, J1
Dobberstein, RC1
Tung, SM1
Babikian, T1
Marion, SD1
Copeland, S1
Alger, JR1
O'Neill, J1
Cazalis, F1
Mink, R1
Giza, CC1
Vu, JA1
Hilleary, SM1
Kernan, CL1
Newman, N1
Asarnow, RF1
Raininko, R1
Mattsson, P1
Thorpe, CT1
Streeter, I1
Pinchbeck, GL1
Goodship, AE1
Clegg, PD1
Birch, HL1
Nakada, T2
Potier, B1
Billard, JM1
Rivière, S1
Sinet, PM1
Denis, I1
Champeil-Potokar, G1
Grintal, B1
Jouvenceau, A1
Kollen, M1
Dutar, P1
Watanabe, T1
Shiino, A1
Akiguchi, I1
Meissner, C1
Xu, W1
Zhan, Y1
Huang, W1
Zhang, S1
Lei, H1
O'Brien, FM1
Page, L1
O'Gorman, RL1
Bolton, P1
Sharma, A1
Baird, G1
Daly, E1
Hallahan, B1
Conroy, RM1
Foy, C1
Curran, S1
Robertson, D1
Murphy, KC1
Murphy, DG1
Lalo, U1
Palygin, O1
North, RA1
Verkhratsky, A1
Pankratov, Y1
Reyngoudt, H1
Claeys, T1
Vlerick, L1
Verleden, S1
Acou, M1
Deblaere, K1
De Deene, Y1
Audenaert, K1
Goethals, I1
Achten, E2
Ruggieri, M1
Tortorella, C1
Ceci, E1
Paolicelli, D1
Solfrizzi, V1
Di Bitonto, G1
Pica, C1
Mastrapasqua, M1
Livrea, P1
Trojano, M1
Schuster, L1
Essig, M1
Schröder, J1
George, IC1
Jayawickrama, N1
Babb, JS2
Perry, NN1
Govind, V1
Arheart, KL1
Yamamoto, T4
Ohtani, S9
Mullins, ME1
Zheng, DD1
Liu, ZH1
Fang, J1
Wang, XY1
Zhang, J1
Wu, WE1
Gass, A1
Glodzik, L1
Hirsch, J1
Sollberger, M1
Achtnichts, L1
Amann, M1
Monsch, AU1
Sivan, SS2
Van El, B1
Merkher, Y1
Schmelzer, CE1
Zuurmond, AM1
Heinz, A1
Wachtel, E2
Varga, PP1
Lazary, A1
Brayda-Bruno, M1
Maroudas, A3
Shimizu, K1
Kita, A1
Miki, K1
Chen, SQ1
Cai, Q1
Shen, YY1
Wang, PJ1
Teng, GJ1
Zhang, W1
Zang, FC1
Li, B1
Hertz, L1
Peng, L1
Abe, O1
Yahata, N1
Kuwabara, H1
Natsubori, T1
Iwashiro, N1
Takano, Y1
Inoue, H1
Kawakubo, Y1
Gonoi, W1
Sasaki, H2
Murakami, M1
Katsura, M1
Nippashi, Y1
Takao, H1
Kunimatsu, A1
Matsuzaki, H1
Tsuchiya, KJ1
Kato, N1
Kasai, K1
Yamasue, H1
Hooi, MY1
Salehi, B1
Preuss, N1
van der Veen, JW1
Shen, J1
Neumeister, A1
Drevets, WC1
Hodgkinson, C1
Goldman, D1
Wendland, JR1
Singleton, A1
Gibbs, JR1
Cookson, MR1
Hasler, G1
Morgan, JJ1
Kleven, GA1
Tulbert, CD1
Olson, J1
Horita, DA1
Ronca, AE1
Bertolino, A2
Roffman, JL1
Lipska, BK1
van Gelderen, P1
Olson, A1
Weinberger, DR2
Sijens, PE2
den Heijer, T1
Origgi, D1
Vermeer, SE1
Breteler, MM2
Hofman, A2
Oudkerk, M2
Laumeier, I2
Collins, M1
Hipkiss, AR1
Valenzuela, MJ2
Jones, M1
Wen, W3
Rae, C1
Graham, S1
Shnier, R2
Sachdev, P1
VERNADAKIS, A1
WOODBURY, DM1
CURATOLO, A1
D ARGANGELO, P1
BRANCATI, A1
CECCHI, L1
WENDER, M1
WALIGORA, Z1
BERL, S1
SMITH, RM1
OSBORNE-WHITE, WS1
RUSSELL, GR1
Rao, R1
Townsend, EL1
Gruetter, R1
Georgieff, MK1
Driscoll, I1
Hamilton, DA1
Petropoulos, H1
Yeo, RA1
Baumgartner, RN1
Sutherland, RJ1
Collins, MJ3
Lanthier, J1
Desrosiers, RR1
Ishiura, S1
Mabuchi, Y1
Urakami-Manaka, Y1
Nishio, H1
Nishiuchi, Y1
Tsunemi, M1
Takada, K1
Watanabe, M1
Ikeda, M1
Matsui, H1
Tomioka, S1
Kawahara, H1
Hamamoto, T1
Suzuki, K2
Kagawa, Y1
Takeuchi, N1
Tezuka, T1
Kuge, K2
Kamei, A1
Saito, T2
Ernst, T1
Chang, L1
Hagopian, K1
Ramsey, JJ1
Weindruch, R1
Miura, Y1
Tajima, S2
Funayama, T1
Ishikawa, K1
Ohtake, Y1
Tanino, T1
Kurosaka, D1
Kimura, I1
Ideta, H1
Nakamoto, K1
Yasuda, N1
Fujimaki, T1
Murakami, A1
Asaoka, R1
Hotta, Y1
Tanihara, H1
Kanamoto, T1
Mishima, H1
Fukuchi, T1
Abe, H1
Iwata, T1
Shimada, N1
Kudoh, J1
Shimizu, N1
Mashima, Y1
Szentkuti, A1
Guderian, S1
Schiltz, K1
Kaufmann, J1
Münte, TF1
Heinze, HJ1
Düzel, E1
Almaguer-Melian, W1
Cruz-Aguado, R1
Riva, Cde L1
Kendrick, KM1
Frey, JU1
Bergado, J1
van Dam, PS1
de Winter, CF1
de Vries, R1
van der Grond, J2
Drent, ML1
Lijffijt, M1
Kenemans, JL1
Aleman, A1
de Haan, EH1
Koppeschaar, HP1
Kaiser, LG1
Schuff, N3
Cashdollar, N1
Weiner, MW4
Moreno-Torres, A1
Pujol, J1
Soriano-Mas, C1
Deus, J1
Iranzo, A1
Santamaria, J1
Pears, MR1
Cooper, JD1
Mitchison, HM1
Mortishire-Smith, RJ1
Pearce, DA1
Griffin, JL1
Girard, N2
Fogliarini, C1
Viola, A2
Confort-Gouny, S1
Fur, YL1
Viout, P2
Chapon, F1
Levrier, O1
Cozzone, P1
Abe, I3
Tsitron, E1
Roughley, PJ1
Sakkee, N1
van der Ham, F1
DeGroot, J1
Roberts, S1
Ross, AJ1
Sachdev, PS2
Brodaty, H2
Guillozet-Bongaarts, AL1
Cahill, ME1
Cryns, VL1
Reynolds, MR1
Berry, RW1
Binder, LI1
Namboodiri, AM1
Peethambaran, A1
Mathew, R1
Sambhu, PA1
Hershfield, J1
Moffett, JR1
Madhavarao, CN1
Meyerhoff, DJ2
Mueller, S1
Chao, L1
Sacrey, DT1
Laxer, K1
Gouny, SC1
Le Fur, Y1
Chaumoitre, K1
D'Ercole, C1
Gire, C1
Figarella-Branger, D1
Cozzone, PJ1
Kinoshita, Y1
Yekkala, R1
Meers, C1
Hoogmartens, J1
Lambrichts, I1
Willems, G1
Van Schepdael, A1
Charlton, RA2
McIntyre, DJ2
Howe, FA3
Morris, RG1
Markus, HS2
Riederer, F2
Lehner-Baumgartner, E1
Baumgartner, C1
Mlynárik, V2
Gruber, S2
Moser, E2
Kaya, M1
Serles, W2
Pinker, K1
Chmelík, M1
Stadlbauer, A1
Frey, R1
Bodamer, O1
Yiannoutsos, CT1
Nakas, CT1
Navia, BA1
Soskić, V1
Groebe, K1
Schrattenholz, A1
Zimmerman, ME1
Pan, JW1
Hetherington, HP1
Katz, MJ1
Verghese, J1
Buschke, H1
Derby, CA1
Lipton, RB1
Casey, PA1
McKenna, MC1
Fiskum, G1
Saraswati, M1
Robertson, CL1
Tyce, GM1
Wong, KL1
Rogers, LJ1
Hambley, JW1
Matsumoto, H2
Kikuchi, S1
Ito, M3
Brooksbank, BW1
Atkinson, DJ1
Balázs, R2
Olney, JW3
Price, MT2
Rajeswari, TS1
Radha, E1
Meier, E1
Drejer, J1
Schousboe, A2
Boehm, MF1
Bada, JL6
Pusateri, ME1
Crow, SE1
Buchsbaum, S1
Lowry, OH1
Masters, PM4
Man, EH3
Sandhouse, ME1
Burg, J1
Fisher, GH3
Pautet, F1
Miyake, M2
Kakimoto, Y2
Sorimachi, M2
de Koning-Verest, IF1
Dawson, R2
Patterson, TA1
Eppler, B1
Stegink, LD2
Lindgren, SD1
Brummel, MC1
Stumbo, PJ1
Wolraich, ML1
Strolin Benedetti, M1
Dostert, P1
Marrari, P1
Cini, M1
Paranandi, MV1
Aswad, DW2
Chang, C1
Jang, T1
Martínez, M1
Hernanz, A1
Ferrándiz, ML1
De Juan, E1
Sevila, I1
Martínez, N1
Miquel, J1
Sugimoto, H2
Sugeno, H2
Yamamoto, S1
Yamamoto, K1
Charles, HC1
Lazeyras, F1
Krishnan, KR1
Boyko, OB1
Patterson, LJ1
Doraiswamy, PM1
McDonald, WM1
Satoh, K2
Harada, K7
Ishibashi, Y2
Varga, V1
Janáky, R1
Marnela, KM1
Salceda, R1
Vilchis, MC1
Flavin, HJ1
Seyfried, TN1
Facchinetti, F1
Dall'Olio, R1
Ciani, E1
Sparapani, M1
Virgili, M1
Contestabile, A1
Raza, A2
Milbrandt, JC1
Arneric, SP2
Caspary, DM2
MacKay, S1
Constans, JM1
Norman, D1
Van Dyke, C1
Fein, G1
Kornhuber, ME1
Kornhuber, J1
Retz, W1
Riederer, P1
Fujino, M1
Christiansen, P1
Toft, P1
Larsson, HB1
Stubgaard, M1
Henriksen, O1
Saleh, N1
Deutsch, D1
Gil-Av, E1
Ferraris, RP1
Vinnakota, RR1
Ritz, S2
Schütz, HW3
Hashimoto, A2
Kumashiro, S1
Nishikawa, T1
Oka, T2
Takahashi, K1
Mito, T1
Takashima, S2
Doi, N1
Mizutani, Y1
Yamazaki, T1
Parnetti, L1
Lowenthal, DT1
Presciutti, O1
Pelliccioli, GP2
Palumbo, R1
Gobbi, G2
Chiarini, P1
Palumbo, B1
Tarducci, R2
Senin, U2
Jenkins, BG1
Brouillet, E1
Chen, YC1
Storey, E1
Schulz, JB1
Kirschner, P1
Rosen, BR1
Barb, CR1
Campbell, RM1
Armstrong, JD1
Cox, NM1
Stock, R1
Kaatsch, HJ1
Kato, S1
Millar, ID1
Calvert, DT1
Lomax, MA1
Shennan, DB1
Exposito, I1
Mora, F1
Zisapel, N1
Oaknin, S1
Florian, CL1
Williams, SR1
Bhakoo, KK1
Noble, MD1
Maier, M1
Ron, MA1
Arechaga, G1
Sánchez, B1
Alba, F1
Luna, JD1
Prieto, I1
Martínez, JM1
Ramírez, M1
Lim, KO2
Gallyas, F1
Satoh, J1
Takeuchi, AM1
Konishi, Y1
Kunishita, T1
Tabira, T1
Araki, T3
Kato, H3
Nagaki, S1
Shuto, K2
Fujiwara, T2
Itoyama, Y3
Chen, T1
Liu, XH1
Hiranuma, T1
Murase, K1
Kogure, K1
Pilin, A4
Cabala, R3
Herrmannová, M2
Pudil, F4
Gross, R2
Massieu, L1
Tapia, R1
Fukuzako, H1
Hashiguchi, T1
Sakamoto, Y1
Okamura, H1
Doi, W1
Takenouchi, K1
Takigawa, M1
Ahmed, NA1
Radwan, NM1
al-Zahaby, AS1
Abd el-Salam, MM1
Wesley, MH1
Kodituwakku, PW1
Garry, PJ1
Rosenberg, GA1
Agrawal, AK1
Shapiro, BH1
Fletcher, EL1
Kalloniatis, M1
Momose, Y4
Yamasaki, M1
Yamagaki, T1
Nakanishi, H1
Uemura, T1
Takita, M2
Ishii, N3
Saunders, RC1
Mattay, VS1
Bachevalier, J1
Frank, JA1
Bayliss, MT1
Uchitel-Kaushansky, N1
Schneiderman, R1
Gilav, E1
Herndon, JG1
Constantinidis, I1
Moss, MB1
Matsushima, Y2
Kobayashi, Y2
Kishi, K1
Pfefferbaum, A1
Adalsteinsson, E1
Spielman, D1
Sullivan, EV1
Malisza, KL1
Kozlowski, P1
Ning, G1
Bascaramurty, S1
Tuor, UI1
Corsi, C2
Melani, A2
Bianchi, L2
Pepeu, G1
Pedata, F2
Saunders, DE1
van den Boogaart, A1
Griffiths, JR1
Brown, MM1
Lundbom, N1
Barnett, A1
Bonavita, S1
Patronas, N1
Rajapakse, J1
Di Chiro, G1
Davis, AM1
Ward, SC1
Selmanoff, M1
Herbison, AE1
McCarthy, MM1
Akaboshi, M3
Kodama, M1
Fonseca, MI1
Head, E1
Velazquez, P1
Cotman, CW2
Tenner, AJ1
Pow, DV1
Barnett, NL1
de Leeuw, FE1
de Groot, JC1
Heijboer, R1
Chlebovská, K2
Chlebovský, O3
Miranda-Contreras, L1
Benítez-Diaz, PR1
Mendoza-Briceño, RV1
Delgado-Saez, MC1
Palacios-Prü, EL1
Overstreet, LS1
Kinney, GA1
Liu, YB1
Billups, D1
Slater, NT1
Takemoto, LJ1
Matsumoto, S2
Hiroki, K2
Anderson, KJ1
Mason, KL1
McGraw, TS1
Theophilopoulos, DT1
Sapper, MS1
Burchfield, DJ1
Cloos, PA1
Fledelius, C1
Yao, FS1
Caserta, MT1
Wyrwicz, AM1
Corda, M1
De Rosa, MC1
Pellegrini, MG1
Sanna, MT1
Olianas, A1
Fais, A1
Manca, L1
Masala, B1
Zappacosta, B1
Ficarra, S1
Castagnola, M1
Giardina, B1
Sashima, M1
Satoh, M1
Leary, SM1
Brex, PA1
MacManus, DG1
Parker, GJ1
Barker, GJ1
Miller, DH1
Nishina, M1
Kato, T1
Wolosker, H1
D'Aniello, A1
Snyder, SH1
Buddington, RK1
Malo, C1
Sangild, PT1
Elnif, J1
Fedorocko, P1
Macková, NO1
Sándorcínová, Z1
Sedláková-Hoferová, Z1
Solár, P1
Ooboshi, H1
Ibayashi, S1
Takano, K1
Sadoshima, S1
Kondo, A1
Uchimura, H1
Fujishima, M1
Gillies, D1
Grachev, ID3
Apkarian, AV3
Angelie, E1
Bonmartin, A1
Boudraa, A1
Gonnaud, PM1
Mallet, JJ1
Sappey-Marinier, D1
Kadota, T1
Horinouchi, T1
Kuroda, C1
Okada, M1
Okuma, Y1
Osumi, Y1
Nishihara, M1
Yokotani, K1
Ueno, H1
Swarnkar, A1
Szeverenyi, NM1
Ramachandran, TS1
Ezekiel, F1
Gamst, AC1
Amend, DL1
Capizzano, AA1
Brooks, JC1
Roberts, N1
Kemp, GJ1
Gosney, MA1
Lye, M1
Whitehouse, GH1
Lafuente, A2
Fenández-Rey, E1
Seara, R1
Pérez-Lorenzo, M1
Esquifino, AI3
Bencko, V2
Miyoshi, H1
Otsuka, H1
Nishitani, H1
Uno, M2
Catani, M1
Cherubini, A1
Howard, R1
Piccirilli, M1
Mecocci, P1
Nagahiro, S1
Zhao, S1
Feng, Y1
LeBlanc, MH1
Liu, YM1
Sinakevitch, I1
Farris, SM1
Strausfeld, NJ1
Takemoto, L2
Ikegaya, Y1
Yamada, M1
Fukuda, T1
Kuroyanagi, H1
Shirasawa, T1
Nishiyama, N1
Carbone, S1
Ponzo, O1
Szwarcfarb, B1
Rondina, D1
Reynoso, R1
Scacchi, P1
Alberto Moguilevsky, J1
García Bonacho, M1
Arce, A1
Cutrera, RA1
Cardinali, DP1
Ahlers, I1
Ahlersová, E1
Bacenková, D1
Filippi, CG1
Uluğ, AM1
Deck, MD1
Zimmerman, RD1
Heier, LA1
Gruss, M1
Braun, K1
Ghandour, H1
Lin, BF1
Choi, SW1
Mason, JB1
Selhub, J1
Fujimoto, N1
Shimo-Oka, T1
Tanaka, T1
Nakajima, T1
Jackson, RC1
Morris, HP1
Weber, G1
Huang, YZ1
Knox, EW1
Zigler, JS2
Robinson, AB1
McKerrow, JH1
Sarhan, S1
Seiler, N1
Grove, J1
Bink, G1
Itoh, H1
Kishi, T1
Iwasawa, Y1
Kawashima, K1
Chibata, I1
D'Adamo, AF1
Wertman, E1
Foster, F1
Schneider, H1
DeLong, R1
Poplin, L1
Helfman, PM3
Shou, MY1
Van den Berg, CJ1
Ronda, G1
Tremblay, GC1
Jimenez, U1
Crandall, DE1
Meldrum, MJ1
Glenton, P1
Slater, P2
McConnell, S2
D'Souza, SW2
Barson, AJ2
Simpson, MD1
Gilchrist, AC1
Banay-Schwartz, M2
Lajtha, A3
Palkovits, M2
Sharma, R1
Dey, S1
Verma, R1
Powell, JT1
Vine, N1
Crossman, M1
Cherici, G1
Alesiani, M1
Pellegrini-Giampietro, DE1
Moroni, F1
Nishimura, S1
Morita, Y1
Westergaard, N1
Sonnewald, U1
Petersen, SB1
Hida, K1
Kwee, IL1
Emmons, T1
Burri, R2
Steffen, C1
Herschkowitz, N2
Erdö, SL1
Wolff, JR1
Lawhorn Armour, BA1
Pippin, J1
Ferrari, MD1
Odink, J1
Bos, KD1
Malessy, MJ1
Bruyn, GW1
Bigler, P1
Straehl, P1
Posse, S1
Colombo, JP1
Peñafiel, R1
Galindo, JD1
Cremades, A1
Monserrat, F1
Gaiarsa, JL1
Corradetti, R1
Cherubini, E3
Ben-Ari, Y5
Palmer, E1
Nangel-Taylor, K1
Krause, JD1
Roxas, A1
Ikeda, H1
Robbins, J1
Kay, CD1
van der Knaap, MS1
van Rijen, PC1
Faber, JA1
Valk, J1
Willemse, K1
Bourguignon, JP1
Gerard, A1
Mathieu, J1
Mathieu, A1
Franchimont, P1
Zhao, XH1
Nomura, Y1
Treves, C1
Favilli, F1
Stio, M1
Iantomasi, T1
Vincenzini, MT1
Groenen, PJ1
van den Ijssel, PR1
Voorter, CE1
Bloemendal, H2
de Jong, WW1
Garcia, NM2
Payan, IL2
Cadilla-Perezrios, R2
Sheremata, WA1
May, PC1
Kohama, SG1
Finch, CE1
Mody, I1
Salter, MW1
MacDonald, JF1
Krnjević, K2
Represa, A2
Tremblay, E2
Guiramand, J1
Sassetti, I1
Recasens, M1
Dudek, SM1
Bear, MF1
Muraoka, S3
O'Connor, CM1
Germain, BJ1
Guthrie, KM1
Millette, CF1
Garthwaite, J3
Muramoto, O1
Kanazawa, I1
Arai, H1
Kosaka, K1
Iizuka, R1
Schmidt, W1
Wolf, G1
Ellison, DW1
Mazurek, MF1
Bird, ED1
Martin, JB1
Aprikyan, GV1
Gekchyan, KG1
Angelatou, F1
Mitsacos, A1
Goulas, V1
Kouvelas, ED1
Roisin, MP1
Charriaut-Marlangue, C1
van den Oetelaar, PJ1
Hoenders, HJ1
Garthwaite, G2
McDonald, JW1
Silverstein, FS1
Johnston, MV1
Tsujioka, H1
Wasa, T1
Hamon, B1
Heinemann, U1
Cicero, TJ1
Meyer, ER1
Bell, RD1
Tamanoi, I3
Joshima, H2
Kashima, M2
Yamini, B1
Brady, RJ1
Swann, JW1
Chemburkar, R1
Arends, G1
Frey, WH1
Filer, LJ1
Baker, GL1
Bell, EF1
Herrero, E1
Aragon, MC1
Diez-Guerra, J1
Valdivieso, F1
Gimenez, C1
Cutler, RW1
Dudzinski, DS1
Bodansky, O1
Schwartz, MK1
Nisselbaum, JS1
Manley, G1
Mullinger, RN1
Lloyd, PH1
Greengard, O1
Federman, M1
Knox, WE1
Heller, W1
Higi, M1
Junger, H1
Hausdörfer, J1
Bemiller, JN1
Hoffmann, WE1
Pappelis, AJ1
De Loecker, W1
Stas, ML1
Roach, MK1
Corbin, J1
Pennington, W1
Macaione, S1
Ruggeri, P1
De Luca, F1
Tucci, G1
Patel, AJ1
Michaelson, IA1
Cremer, JE1
Agrawal, HC1
Davis, JM1
Himwich, WA1
Ebel, A1
Mack, G1
Fontaine, R1
Schoenmakers, JG1
Gerding, JJ1
Wen, CP1
Gershoff, SN1
Acharya, PV1
Jackson, DS1
Lerman, S1
Burton, RM1
Buniatian, HCh1
Aprikian, GV1
Mkrtchian, GN1
Navon, S1
Gaitonde, MK1
Richter, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180]70 participants Observational2003-06-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

20 reviews available for aspartic acid and Aging

ArticleYear
D-Amino acids in protein: The mirror of life as a molecular index of aging.
    Biochimica et biophysica acta. Proteins and proteomics, 2018, Volume: 1866, Issue:7

    Topics: Aging; Aspartic Acid; Chromatography, Liquid; Humans; Proteins; Stereoisomerism; Tandem Mass Spectro

2018
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis.
    Neuroscience and biobehavioral reviews, 2013, Volume: 37, Issue:8

    Topics: Age Factors; Aging; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Humans; Magnetic R

2013
Isomerization of aspartyl residues in crystallins and its influence upon cataract.
    Biochimica et biophysica acta, 2016, Volume: 1860, Issue:1 Pt B

    Topics: Aging; Amino Acid Sequence; Animals; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens,

2016
Recent advances in mass spectrometric analysis of protein deamidation.
    Mass spectrometry reviews, 2017, Volume: 36, Issue:6

    Topics: Aging; Aspartic Acid; Databases, Protein; Humans; Mass Spectrometry; Neurodegenerative Diseases; Pep

2017
Conversion of brain cytosol profile from fetal to adult type during the perinatal period: taurine-NAA exchange.
    Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2010, Volume: 86, Issue:6

    Topics: Adult; Aging; Animals; Aspartic Acid; Brain; Cytosol; Fetus; Humans; Magnetic Resonance Spectroscopy

2010
Molecular pathology and age estimation.
    Forensic science international, 2010, Dec-15, Volume: 203, Issue:1-3

    Topics: Age Determination by Teeth; Aging; Aspartic Acid; Bone and Bones; Dental Enamel; Dentin; DNA, Mitoch

2010
D-amino acid in elderly tissues.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9

    Topics: Aged; Aging; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Crystallins;

2005
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
    Molecular and cellular endocrinology, 2006, Jun-27, Volume: 252, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Humans; Mice; Mice, Knockout

2006
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries;

2006
Nonenzymatic posttranslational protein modifications in ageing.
    Experimental gerontology, 2008, Volume: 43, Issue:4

    Topics: Aging; Asparagine; Aspartic Acid; Deamination; Glycation End Products, Advanced; Humans; Maillard Re

2008
Trophic actions of GABA on the development of physiologically active GABA receptors.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Aging; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Hum

1983
[Endogenous free D-aspartate and D-serine in mammals].
    Seikagaku. The Journal of Japanese Biochemical Society, 1996, Volume: 68, Issue:8

    Topics: Adrenal Glands; Aging; Animals; Aspartic Acid; Brain; Kidney; Liver; Male; Serine; Testis

1996
The mechanisms of simultaneous stereoinversion, racemization, and isomerization at specific aspartyl residues of aged lens proteins.
    Mechanisms of ageing and development, 1999, Mar-15, Volume: 107, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; Isomerism;

1999
Racemization of aspartic acid in human proteins.
    Ageing research reviews, 2002, Volume: 1, Issue:1

    Topics: Aging; Amides; Animals; Aspartic Acid; Humans; Proteins; Stereoisomerism

2002
Molecular clocks, molecular profiles, and optimum diets: three approaches to the problem of aging.
    Mechanisms of ageing and development, 1979, Volume: 9, Issue:3-4

    Topics: Adult; Aging; Amides; Amines; Animals; Ascorbic Acid; Aspartic Acid; Biological Clocks; Diet; Humans

1979
Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review.
    Mechanisms of ageing and development, 1979, Volume: 10, Issue:6

    Topics: Aging; Amides; Amino Acids; Animals; Asparagine; Aspartic Acid; Glutamine; Half-Life; Isomerism; Mod

1979
Excitotoxin-mediated neuron death in youth and old age.
    Progress in brain research, 1990, Volume: 86

    Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases, Metabolic; Brain Inju

1990
Isozymes of aspartate aminotransferase in tissues and blood of man.
    Advances in enzyme regulation, 1966, Volume: 4

    Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; B

1966
Maturational changes in amino acids in CNS of different mammalian species.
    Recent advances in biological psychiatry, 1968, Volume: 10

    Topics: Aging; Amino Acids; Amino Alcohols; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Cats; D

1968
Effects of diet and stages of development on intestinal cells and enzymes.
    Nutrition reviews, 1971, Volume: 29, Issue:5

    Topics: Aging; Aminohydrolases; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Aspar

1971

Trials

8 trials available for aspartic acid and Aging

ArticleYear
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adult; Aged; Aging; Aspartic Acid; Choline; Creatinine; Diffusion Tensor Imaging; Female; Gait Disor

2015
The aging hippocampus: cognitive, biochemical and structural findings.
    Cerebral cortex (New York, N.Y. : 1991), 2003, Volume: 13, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Choline; Cognition; Creatine; Female; Hippocam

2003
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate.
    Psychoneuroendocrinology, 2005, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Age of Onset; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; C

2005
Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame.
    The American journal of clinical nutrition, 1995, Volume: 62, Issue:6

    Topics: Aging; Analysis of Variance; Aspartame; Aspartic Acid; Child; Child Behavior; Child, Preschool; Cogn

1995
Proton spectroscopy of human brain: effects of age and sex.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnet

1994
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
    Domestic animal endocrinology, 1996, Volume: 13, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Respo

1996
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 76, Issue:2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A

2001
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female

2001

Other Studies

346 other studies available for aspartic acid and Aging

ArticleYear
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
    Neurobiology of aging, 2022, Volume: 109

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Fem

2022
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice.
    Neurochemical research, 2022, Volume: 47, Issue:9

    Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Cognition; Cognitive Dysfunction; Hippocampus; Mi

2022
The Aging Process: A Metabolomics Perspective.
    Molecules (Basel, Switzerland), 2022, Dec-07, Volume: 27, Issue:24

    Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Female; Humans; Isoleucine; Leucine; Male; Metabolome

2022
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
    NeuroImage, 2023, 02-01, Volume: 266

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor

2023
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
    NeuroImage. Clinical, 2023, Volume: 37

    Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P

2023
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
    Clinical neuroradiology, 2023, Volume: 33, Issue:4

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet

2023
d-aspartate treatment in vitro improves mouse sperm fertility in young B6N mice.
    Theriogenology, 2020, Volume: 148

    Topics: Acrosome Reaction; Aging; Animals; Aspartic Acid; Cryopreservation; Embryo Transfer; Embryo, Mammali

2020
Age-related isomerization of Asp in human immunoglobulin G kappa chain.
    Biochimica et biophysica acta. Proteins and proteomics, 2020, Volume: 1868, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Cataract; Chromatography, Liquid; Humans; Immunoglobu

2020
Changes in the intracellular microenvironment in the aging human brain.
    Neurobiology of aging, 2020, Volume: 95

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M

2020
Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk.
    Biology of sex differences, 2020, 10-22, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aging; Asian People; Asparagine; Aspartic Acid; China; Diabetes Mellitus, Type 2;

2020
[Comparative assessment of technical approaches to estimating the biological age of a person using chromatographic analysis of dentin].
    Sudebno-meditsinskaia ekspertiza, 2021, Volume: 64, Issue:2

    Topics: Age Determination by Teeth; Aging; Aspartic Acid; Dentin; Humans; Russia

2021
Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide.
    PloS one, 2021, Volume: 16, Issue:4

    Topics: Aging; Alanine; alpha-Crystallin A Chain; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Asp

2021
Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.
    Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL

2021
Racemization in cataractous lens from diabetic and aging individuals: analysis of Asp 58 residue in αA-crystallin.
    Aging, 2021, 06-07, Volume: 13, Issue:11

    Topics: Aged; Aging; Aspartic Acid; Cataract; Cell Nucleus; Crystallins; Female; Humans; Isomerism; Lens, Cr

2021
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using
    Neuroscience, 2017, 06-23, Volume: 354

    Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Creatine; Dipeptides;

2017
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats.
    Hearing research, 2017, Volume: 350

    Topics: Acetylcholine; Age Factors; Aging; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Brain; Ch

2017
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age.
    Aging & mental health, 2019, Volume: 23, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Attention; Brain; Brain-Derived Neurotro

2019
Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens.
    Biochimica et biophysica acta. Proteins and proteomics, 2018, Volume: 1866, Issue:7

    Topics: Aged; Aging; Aspartic Acid; beta-Crystallin B Chain; Chromatography, High Pressure Liquid; Chromatog

2018
Asp 58 modulates lens αA-crystallin oligomer formation and chaperone function.
    The FEBS journal, 2018, Volume: 285, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Animals; Aspartic Acid; beta-Crystallins; Cattl

2018
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
    Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:3

    Topics: Administration, Intranasal; Aging; Animals; Antibodies; Aspartic Acid; Avoidance Learning; Condition

2019
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019, Volume: 27, Issue:8

    Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Cre

2019
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2019, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc

2019
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019, Volume: 130, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose;

2019
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
    Neuroscience bulletin, 2020, Volume: 36, Issue:1

    Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; F

2020
Kinetics of isomerization and inversion of aspartate 58 of αA-crystallin peptide mimics under physiological conditions.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Child; C

2013
Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle.
    Biochemical and biophysical research communications, 2013, Apr-12, Volume: 433, Issue:3

    Topics: Action Potentials; Aging; Animals; Aspartic Acid; Caenorhabditis elegans; Caenorhabditis elegans Pro

2013
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:6

    Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus;

2013
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
    Arquivos de neuro-psiquiatria, 2013, Volume: 71, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di

2013
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.
    Experimental gerontology, 2013, Volume: 48, Issue:8

    Topics: Adult; Aged; Aging; Aspartic Acid; Audiometry, Pure-Tone; Auditory Cortex; Case-Control Studies; Fem

2013
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem

2014
Motor system alterations in retired former athletes: the role of aging and concussion history.
    BMC neurology, 2013, Aug-26, Volume: 13

    Topics: Age Factors; Aged; Aging; Analysis of Variance; Apolipoproteins E; Aspartic Acid; Brain; Brain Concu

2013
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
    Journal of child neurology, 2014, Volume: 29, Issue:2

    Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glu

2014
Faster metabolite (1)H transverse relaxation in the elder human brain.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adolescent; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cellular Microenvironment; Choline; Creat

2013
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebe

2014
Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.
    International journal of legal medicine, 2014, Volume: 128, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Elastin; Epiglottis; Forensic Path

2014
Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.
    Neurochemical research, 2014, Volume: 39, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Glutamate Dehydrogenase; Glutamic Acid; Hippocampus;

2014
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
    American journal of veterinary research, 2014, Volume: 75, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Female; Lactic Acid; Magnetic Resonan

2014
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.
    Neurobiology of aging, 2014, Volume: 35, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Functional Neuroimaging; Glucose; Glutamic Acid; Magn

2014
The partial volume effect in the quantification of 1H magnetic resonance spectroscopy in Alzheimer's disease and aging.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Cogni

2014
Age related changes in metabolite concentrations in the normal spinal cord.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine;

2014
Education mitigates age-related decline in N-Acetylaspartate levels.
    Brain and behavior, 2015, Volume: 5, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Cognitive Reserve; Educational Status; Female; Frontal Lobe; Humans; Mag

2015
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
    Brain imaging and behavior, 2016, Volume: 10, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc

2016
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
    The British journal of radiology, 2015, Volume: 88, Issue:1052

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glu

2015
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
    Neurobiology of aging, 2015, Volume: 36, Issue:11

    Topics: Acetylcholine; Aging; Animals; Antioxidants; Aspartic Acid; Brain; Carnitine; DNA Damage; DNA Polyme

2015
Age estimation based on aspartic acid racemization in human sclera.
    International journal of legal medicine, 2016, Volume: 130, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Chromatography, Gas; Female

2016
Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens.
    Rejuvenation research, 2016, Volume: 19, Issue:4

    Topics: Age Factors; Aging; Animals; Aspartic Acid; Biomarkers; Chromatography, High Pressure Liquid; Eye Pr

2016
Isomerization of Asp residues plays an important role in αA-crystallin dissociation.
    The FEBS journal, 2016, Volume: 283, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract; Chromatogr

2016
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 27

    Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional S

2016
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin

2016
Physiological neuronal decline in healthy aging human brain - An in vivo study with MRI and short echo-time whole-brain (1)H MR spectroscopic imaging.
    NeuroImage, 2016, Aug-15, Volume: 137

    Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Imaging; Ma

2016
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
    Neuroradiology, 2016, Volume: 58, Issue:10

    Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child,

2016
Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?
    Acta neuropathologica communications, 2016, 08-12, Volume: 4, Issue:1

    Topics: Adult; Aged; Aging; Arginine; Aspartic Acid; Cerebellum; Glutamine; Humans; Isoaspartic Acid; Mass S

2016
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a
    Neurobiology of aging, 2016, Volume: 48

    Topics: Aged; Aging; Aspartic Acid; Energy Metabolism; Female; Gray Matter; Gyrus Cinguli; Humans; Magnetic

2016
Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.
    Rheumatology (Oxford, England), 2017, Volume: 56, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alkaptonuria; Aspartic Acid; Biomarkers; Cartilage Oligomeric

2017
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre

2017
Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants?
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:9

    Topics: Aging; Aspartic Acid; Basal Ganglia; Child Development; Choline; Cohort Studies; Follow-Up Studies;

2008
Oxidative stress as regulatory factor for fatty-acid-induced uncoupling involving liver mitochondrial ADP/ATP and aspartate/glutamate antiporters of old rats.
    Biochemistry. Biokhimiia, 2008, Volume: 73, Issue:7

    Topics: Aging; Amino Acid Transport System X-AG; Animals; Antioxidants; Antiporters; Aspartic Acid; Atractyl

2008
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats.
    Pharmaceutical research, 2008, Volume: 25, Issue:12

    Topics: Aging; Alprostadil; Animals; Aspartic Acid; Drug Delivery Systems; Estrogens; Female; Fluorescein-5-

2008
Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T.
    Magnetic resonance in medicine, 2008, Volume: 60, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spec

2008
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.
    Journal of child neurology, 2009, Volume: 24, Issue:1

    Topics: Adolescent; Aging; Aspartic Acid; Basal Ganglia; Case-Control Studies; Cerebral Palsy; Child; Child,

2009
Brain flexibility and balance and gait performances mark morphological and metabolic abnormalities in the elderly.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2008, Volume: 15, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Community Health Planning; Creatine;

2008
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor

2008
Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity.
    Glia, 2009, Volume: 57, Issue:9

    Topics: Aging; Animals; Aspartic Acid; Astrocytes; Biological Transport; Bumetanide; Cells, Cultured; Centra

2009
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
    Annals of neurology, 2009, Volume: 65, Issue:1

    Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschoo

2009
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
    Psychiatry research, 2009, Jun-30, Volume: 172, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi

2009
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid;

2009
Copper deficiency alters the neurochemical profile of developing rat brain.
    Nutritional neuroscience, 2009, Volume: 12, Issue:3

    Topics: Aging; Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Cerebellum; Citric Acid; Coppe

2009
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
    Neurobiology of aging, 2011, Volume: 32, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co

2011
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:1

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Glucose Tolerance Test; Glutamic

2010
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
    Brain research, 2010, Jan-14, Volume: 1309

    Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationsh

2010
Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.
    International journal of legal medicine, 2010, Volume: 124, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aorta, Abdominal; Arteriosclerosis; Aspartic Acid

2010
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Adolescent; Age Factors; Aging; Anisotropy; Aspartic Acid; Axons; Biomarkers; Brain Injuries; Child;

2010
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe

2010
Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging.
    The Journal of biological chemistry, 2010, May-21, Volume: 285, Issue:21

    Topics: Aging; Animals; Aspartic Acid; Biomarkers; Collagen Type I; Female; Horses; Male; Tendon Injuries; T

2010
Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.
    Aging cell, 2010, Volume: 9, Issue:5

    Topics: Aging; Animals; Aspartic Acid; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporte

2010
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
    Dementia and geriatric cognitive disorders, 2010, Volume: 30, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem

2010
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
    Journal of neuroscience research, 2010, Nov-01, Volume: 88, Issue:14

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA

2010
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
    Psychiatry research, 2010, Nov-30, Volume: 184, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch

2010
Age-dependent remodelling of ionotropic signalling in cortical astroglia.
    Aging cell, 2011, Volume: 10, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acid Transport System X-AG; Animals; Aspartic Aci

2011
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
    European journal of radiology, 2012, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine;

2012
Age-related changes of serum N-acetyl-aspartate in healthy controls.
    Age and ageing, 2011, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Pr

2011
[Normal aging and imaging correlations].
    Der Radiologe, 2011, Volume: 51, Issue:4

    Topics: Aging; Aspartic Acid; Brain; Humans; Magnetic Resonance Imaging; Reference Values; Statistics as Top

2011
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2012, Volume: 67, Issue:1

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies;

2012
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonan

2012
Estimation of chronological age from the racemization rate of L- and D-aspartic acid: how to completely separate enantiomers from dentin.
    Methods in molecular biology (Clifton, N.J.), 2012, Volume: 794

    Topics: Aging; Animals; Aspartic Acid; Dentin; Humans; Stereoisomerism

2012
Daydreaming about our metaphorical tool belt.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male

2012
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu

2012
Whole brain N-acetylaspartate concentration is conserved throughout normal aging.
    Neurobiology of aging, 2012, Volume: 33, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Atrophy; Biomarkers; Brain; Brain Chemistry; F

2012
Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid.
    Biochimica et biophysica acta, 2012, Volume: 1820, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Isomerases; Aspartic Acid; Autopsy; Elastin; Femal

2012
Structural features of isomerizable aspartyl residues in human α-crystallins.
    Molecular vision, 2012, Volume: 18

    Topics: Aging; alpha-Crystallin A Chain; alpha-Crystallin B Chain; Amino Acid Sequence; Aspartic Acid; Cloni

2012
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin

2012
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
    Neurochemistry international, 2012, Volume: 61, Issue:8

    Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senesce

2012
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
    Translational psychiatry, 2012, Oct-23, Volume: 2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Humans; Magnetic Res

2012
Accelerated aging of Asp 58 in αA crystallin and human cataract formation.
    Experimental eye research, 2013, Volume: 106

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; alpha-Crystallin A Chain; Aspartic Acid; Cataract

2013
Age-modulated association between prefrontal NAA and the BDNF gene.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Brain-Derived Neurotrophic Factor; Depression; Depressive D

2013
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
    NMR in biomedicine, 2013, Volume: 26, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy;

2013
Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage.
    Cerebral cortex (New York, N.Y. : 1991), 2002, Volume: 12, Issue:9

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Aspartic Acid; Female; Hippocampus; Male; Motor Activ

2002
Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men.
    Radiology, 2003, Volume: 226, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Linear Mode

2003
Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.
    International journal of legal medicine, 2003, Volume: 117, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Elastin; Forensic Medicine; Human

2003
Age-related apoptotic dysfunction: any role for polypeptide aspartate instability?
    Experimental gerontology, 2003, Volume: 38, Issue:5

    Topics: Aging; Apoptosis; Aspartic Acid; Humans; Peptides; Phenotype

2003
Memory training alters hippocampal neurochemistry in healthy elderly.
    Neuroreport, 2003, Jul-18, Volume: 14, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Cortex; Chol

2003
Electrolyte and amino acid changes in rat brain during maturation.
    The American journal of physiology, 1962, Volume: 203

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Chlorides; Glutamates; Glutamine; Nitrogen; Potas

1962
[N-ACETYL-ASPARTIC ACID IN NERVE TISSUE. QUANTITATIVE CHANGES IN THE BRAIN OF GROWING ANIMALS].
    Bollettino della Societa italiana di biologia sperimentale, 1963, Dec-31, Volume: 39

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Nerve Tissue; Poultry; Rats; Research

1963
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates;

1964
COMPARTMENTATION OF GLUTAMIC ACID METABOLISM IN DEVELOPING CEREBRAL CORTEX.
    The Journal of biological chemistry, 1965, Volume: 240

    Topics: Aging; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartic Acid; Brain Chemistry; Cats;

1965
METABOLISM OF PROPIONATE BY SHEEP LIVER. INTERRELATIONS OF PROPIONATE AND GLUTAMATE IN AGED MITOCHONDRIA.
    The Biochemical journal, 1965, Volume: 95

    Topics: Acyl Coenzyme A; Aging; Amino Acids; Animals; Aspartic Acid; Carbon Dioxide; Citrates; Fatty Acids;

1965
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
    The Journal of nutrition, 2003, Volume: 133, Issue:10

    Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female;

2003
Aspartic acid racemization: evidence for marked longevity of elastin in human skin.
    The British journal of dermatology, 2003, Volume: 149, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Aspartic Acid; Child; Child, Prescho

2003
Protein L-isoaspartyl methyltransferase repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration.
    Experimental cell research, 2004, Feb-01, Volume: 293, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Dros

2004
Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.
    Biochemical and biophysical research communications, 2004, Feb-13, Volume: 314, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Caenorhabditis elegans; Cysteine Endope

2004
Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats.
    Amino acids, 2004, Volume: 26, Issue:2

    Topics: Aging; alpha-Crystallin A Chain; Animals; Aspartic Acid; Cataract; Disease Models, Animal; Humans; I

2004
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
    AIDS (London, England), 2004, Jan-01, Volume: 18 Suppl 1

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal

2004
Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.
    Experimental gerontology, 2004, Volume: 39, Issue:8

    Topics: Aging; Animals; Aspartic Acid; Caloric Restriction; Citric Acid; Citric Acid Cycle; Glutamic Acid; K

2004
Kinetic study of racemization of aspartyl residues in synthetic elastin peptides.
    Amino acids, 2004, Volume: 27, Issue:2

    Topics: Aging; Amino Acids; Aspartic Acid; Elastin; Exons; Humans; Isomerism; Kinetics; Peptides; Skin; Temp

2004
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:12

    Topics: Adult; Aging; Alleles; Asian People; Aspartic Acid; Cell Cycle Proteins; Chromatography, High Pressu

2004
Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging.
    Journal of neurology, 2004, Volume: 251, Issue:11

    Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Attention; Brain Chemistry; Ch

2004
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats.
    Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydrox

2005
Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T.
    Neurobiology of aging, 2005, Volume: 26, Issue:5

    Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Chemistry; Creatine; Female; Glutamic

2005
Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy.
    Neurobiology of aging, 2005, Volume: 26, Issue:7

    Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; H

2005
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal;

2005
MRS of normal and impaired fetal brain development.
    European journal of radiology, 2006, Volume: 57, Issue:2

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric

2006
Novel chiral selectors anchored on polydimethylsiloxane as stationary phases for separation of derivatized amino acid enantiomers by capillary gas chromatography.
    Journal of separation science, 2006, Volume: 29, Issue:2

    Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Chromatography, Gas; Dentin; Dimethylpolysiloxanes;

2006
Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid.
    The Journal of biological chemistry, 2006, May-12, Volume: 281, Issue:19

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Aspartic Acid; Biomarkers; Child; Chil

2006
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution;

2006
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
    Journal of neurochemistry, 2006, Volume: 97, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar

2006
Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2006, Volume: 56, Issue:4

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Brain Chemistry; Female; Fetal Development; Gestational Age

2006
Age-dependent changes in the racemisation ratio of aspartic acid in human alveolar bone.
    Archives of oral biology, 2007, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; D-Aspartic Acid; Female; Femur; Humans; Male;

2007
An improved sample preparation for an LC method used in the age estimation based on aspartic acid racemization from human dentin.
    Journal of separation science, 2007, Volume: 30, Issue:1

    Topics: Age Factors; Aging; Aspartic Acid; Chromatography, Liquid; Dentin; Humans; Isomerism

2007
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
    Brain research, 2007, Aug-20, Volume: 1164

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Cognition; Cognition Disorders; Cross-Sectiona

2007
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
    Brain research, 2007, Nov-07, Volume: 1179

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe

2007
Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy.
    European journal of radiology, 2008, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Imaging, Th

2008
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
    Journal of magnetic resonance imaging : JMRI, 2007, Volume: 26, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema

2007
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
    NeuroImage, 2008, Mar-01, Volume: 40, Issue:1

    Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr

2008
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
    Neurology, 2008, Apr-29, Volume: 70, Issue:18

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Reson

2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
    Journal of neurotrauma, 2008, Volume: 25, Issue:6

    Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C

2008
Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats.
    Experimental gerontology, 1980, Volume: 15, Issue:6

    Topics: Age Factors; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Female; gamma-Aminobutyric Acid; G

1980
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
    Behavioural brain research, 1982, Volume: 4, Issue:1

    Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Gluta

1982
Age-related changes in the glutamate metabolism of cerebral cortical slices from rats.
    Neurochemical research, 1982, Volume: 7, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates;

1982
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
    Journal of neuroscience research, 1982, Volume: 8, Issue:4

    Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lo

1982
Excitotoxic amino acids as neuroendocrine research tools.
    Methods in enzymology, 1983, Volume: 103

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Axons; Blood-Brain Barrier; Brain; Glutamates; Glutamic

1983
Metabolism of the glutamate group of amino acids in rat brain as a function of age.
    Mechanisms of ageing and development, 1984, Volume: 24, Issue:2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Energy Metabolism; Enzymes; gamma-Aminob

1984
Investigations of in vivo methionine racemization in mammalian tissues.
    Biochemistry international, 1984, Volume: 8, Issue:5

    Topics: Aging; Animals; Aspartic Acid; Chromatography, Gas; Dentin; Hydrogen-Ion Concentration; Kinetics; Le

1984
Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain.
    Journal of neurochemistry, 1984, Volume: 42, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Hypothalamus; Kinetics; Mice; Mice, Inbr

1984
Stereochemically altered noncollagenous protein from human dentin.
    Calcified tissue international, 1983, Volume: 35, Issue:1

    Topics: Aging; Aspartic Acid; Dentin; Humans; Kinetics; Protein Conformation; Proteins; Tooth

1983
Accumulation of D-aspartic acid with age in the human brain.
    Science (New York, N.Y.), 1983, Jun-24, Volume: 220, Issue:4604

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Eye Proteins; Humans; Lens Nucleus, Crystalline;

1983
Senile cataracts and aging changes in human proteins.
    Journal of the American Geriatrics Society, 1983, Volume: 31, Issue:7

    Topics: Aged; Aging; Aspartic Acid; Cataract; Crystallins; Humans; In Vitro Techniques; Molecular Weight; Pr

1983
[In vivo amino acid racemization: possible role in the molecular aging of proteins (author's transl)].
    Pathologie-biologie, 1980, Volume: 28, Issue:5

    Topics: Aging; Aspartic Acid; Lens, Crystalline; Proteins; Stereoisomerism; Time Factors; Tooth

1980
A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals.
    Journal of neurochemistry, 1981, Volume: 36, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Carps; Chickens; Chromatography, Gas; Citrates; Colu

1981
Developmental changes of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid in different brain regions and spinal cords of rat and guinea pig.
    Journal of neurochemistry, 1981, Volume: 37, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain; Dipeptides; Glutamates; Guinea Pigs; Organ Specificity; Rats;

1981
Glutamate metabolism in ageing rat brain.
    Mechanisms of ageing and development, 1980, Volume: 13, Issue:1

    Topics: Acetates; Aging; Animals; Aspartic Acid; Brain; Female; Glucose; Glutamates; Glutamine; Rats

1980
Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents.
    Neurochemical research, 1995, Volume: 20, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Excitatory Amino

1995
Effect of ageing on tissue levels of amino acids involved in the nitric oxide pathway in rat brain.
    Journal of neural transmission. General section, 1993, Volume: 94, Issue:1

    Topics: Aging; Amino Acid Oxidoreductases; Amino Acids; Animals; Arginine; Aspartic Acid; Brain Chemistry; C

1993
Studies on age estimation using racemization of aspartic acid in cementum.
    Journal of forensic sciences, 1995, Volume: 40, Issue:5

    Topics: Adult; Age Determination by Teeth; Aged; Aged, 80 and over; Aging; Aspartic Acid; Dental Cementum; D

1995
Spontaneous alterations in the covalent structure of synapsin I during in vitro aging.
    Biochemical and biophysical research communications, 1995, Jul-17, Volume: 212, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Cattle; Cross-Linking Reagents; Disulfides; Electrop

1995
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobut

1995
Glucose deprivation increases aspartic acid release from synaptosomes of aged mice.
    Brain research, 1995, Feb-27, Volume: 673, Issue:1

    Topics: Age Factors; Aging; Animals; Aspartic Acid; Brain; Energy Metabolism; Female; Glucose; Glutamic Acid

1995
Racemization of aspartic acid in human cementum with age.
    Archives of oral biology, 1995, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Age Determination by Teeth; Aged; Aged, 80 and over; Aging; Aspartic Acid; Bicusp

1995
Simultaneous stereoinversion and isomerization at specific aspartic acid residues in alpha A-crystallin from human lens.
    Journal of biochemistry, 1994, Volume: 116, Issue:3

    Topics: Aging; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; Isomerism; Lens, Crystalline; Molecu

1994
Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission.
    Neurochemical research, 1994, Volume: 19, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Brain; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclic

1994
High affinity uptake of glutamate and aspartate in the developing rat retina.
    Current eye research, 1994, Volume: 13, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Retina; Subcellular Fracti

1994
Enhanced aspartate release related to epilepsy in (EL) mice.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca

1994
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
    Neuroscience, 1994, Volume: 60, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Ne

1994
Age-related changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine function.
    Hearing research, 1994, Jun-15, Volume: 77, Issue:1-2

    Topics: 4-Aminobutyrate Transaminase; Acetylcholine; Aging; Animals; Aspartic Acid; Auditory Pathways; Biolo

1994
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
    Annals of neurology, 1994, Volume: 36, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; C

1994
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
    Neuroscience, 1994, Volume: 60, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Femal

1994
L-glutamate and L-aspartate concentrations in the developing and aging human putamen tissue.
    Journal of neural transmission. General section, 1993, Volume: 93, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Female; G

1993
Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.
    Biochimica et biophysica acta, 1994, Feb-16, Volume: 1204, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Amino Acids; Aspartic Acid; Crystallins; Humans

1994
The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium.
    Magnetic resonance imaging, 1993, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Magnetic Res

1993
Racemization of aspartic acid in the extracellular matrix proteins of primary and secondary dentin.
    Calcified tissue international, 1993, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Child; Chromatography, Gas; Dentin; Extracellular Matrix Pr

1993
Regulation of intestinal nutrient transport is impaired in aged mice.
    The Journal of nutrition, 1993, Volume: 123, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Biological Transport; Dietary Carbohydrates; Dietary Pro

1993
Aspartic acid racemization in intervertebral discs as an aid to postmortem estimation of age at death.
    Journal of forensic sciences, 1993, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Humans; Intervertebral Disc

1993
Embryonic development and postnatal changes in free D-aspartate and D-serine in the human prefrontal cortex.
    Journal of neurochemistry, 1993, Volume: 61, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Chromatog

1993
Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain.
    Mechanisms of ageing and development, 1995, Jul-14, Volume: 81, Issue:2-3

    Topics: Aging; Animals; Aspartic Acid; Brain; Female; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Rats

1995
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
    Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud

1996
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease;

1996
Age estimation in biopsy specimens of dentin.
    International journal of legal medicine, 1995, Volume: 108, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Biopsy; Child; Dentin; Forensic Dentistry; Germany; H

1995
Changes in D-aspartic acid in human deciduous teeth with age from 1-20 years.
    Growth, development, and aging : GDA, 1996,Spring, Volume: 60, Issue:1

    Topics: Adolescent; Aging; Aspartic Acid; Child; Child, Preschool; Dentin; Humans; Infant; Stereoisomerism;

1996
Interaction between anionic amino acids and the mammary tissue (Na(+)-glutamate) cotransporter.
    Biochemical Society transactions, 1996, Volume: 24, Issue:2

    Topics: Aging; Amino Acid Transport System X-AG; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Carrier

1996
The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing.
    Neuroreport, 1995, Nov-27, Volume: 6, Issue:17

    Topics: Aging; Amphetamine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; Dopamine

1995
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.
    Neurochemical research, 1996, Volume: 21, Issue:9

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebra

1996
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
    Schizophrenia research, 1996, Oct-18, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali

1996
Developmental changes of soluble and membrane-bound aspartate aminopeptidase activities in rat brain.
    Revista espanola de fisiologia, 1996, Volume: 52, Issue:3

    Topics: Aging; Aminopeptidases; Animals; Aspartic Acid; Brain; Glutamyl Aminopeptidase; Male; Membrane Prote

1996
Estimating NAA in cortical gray matter with applications for measuring changes due to aging.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:3

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Female; Humans; Magnetic Resonance Spectroscopy

1997
Identifying monoaminergic, GABAergic, and cholinergic characteristics in immortalized neuronal cell lines.
    Neurochemical research, 1997, Volume: 22, Issue:5

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Cell Line, Transformed; Cell

1997
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats.
    Mechanisms of ageing and development, 1997, Volume: 95, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpi

1997
Age-related changes of sodium-dependent D-[3H]aspartate and [3H]FK506 binding in rat brain.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Excitatory Amino Acids; Immunosuppressive Age

1997
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat

1997
[Age determination by measurement of the ratio of D- and L- forms of aspartic acid. II. Chiral separation of amino acids from human dentin].
    Soudni lekarstvi, 1997, Volume: 42, Issue:1

    Topics: Age Determination by Teeth; Aging; Aspartic Acid; Chromatography; Dentin; Forensic Medicine; Humans;

1997
[Present possibilities of age determination in forensic medicine with emphasis on the importance of measurement of D- and L- forms of aspartic acid. I. An overview].
    Soudni lekarstvi, 1997, Volume: 42, Issue:1

    Topics: Age Determination by Teeth; Aging; Aspartic Acid; Dentin; Forensic Medicine; Humans; Lens, Crystalli

1997
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hipp

1997
Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects.
    Psychiatry and clinical neurosciences, 1997, Volume: 51, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Mapping; Creatine; Energy Metabolism; Female; Frontal Lobe;

1997
Reserpine effects on neurotransmitters in chick heart during growth.
    Journal of physiology, Paris, 1997, Volume: 91, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Inj

1997
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
    Stroke, 1997, Volume: 28, Issue:10

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Intracranial Arteriosclerosis; Magneti

1997
Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:11

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Blotting, Northern; Blotting, Western; Cytochrome P

1997
Neurochemical development of the degenerating rat retina.
    The Journal of comparative neurology, 1997, Nov-10, Volume: 388, Issue:1

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; gamma-Aminobutyric Acid; Glu

1997
The conformation formed by the domain after alanine-155 induces inversion of aspartic acid-151 in alpha A-crystallin from aged human lenses.
    Biochemical and biophysical research communications, 1997, Oct-29, Volume: 239, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alanine; Amino Acid Sequence; Aspartic Acid; Crystallins; Humans; In

1997
Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study.
    Cerebral cortex (New York, N.Y. : 1991), 1997, Volume: 7, Issue:8

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Choline; Creatine; Entorhinal

1997
Kainate potentiates D-aspartate release from hippocampal slices from developing and ageing mice.
    Proceedings of the Western Pharmacology Society, 1997, Volume: 40

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Excitatory Amino Acid Agonists; Female; Hippocampus

1997
Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age.
    Archives of biochemistry and biophysics, 1998, Feb-01, Volume: 350, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Animals; Aspartic Acid; Cartilage, Articular; Extr

1998
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
    Neurochemical research, 1998, Volume: 23, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippo

1998
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
    Neuroreport, 1998, Jun-22, Volume: 9, Issue:9

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito

1998
Evaluation of aspartic acid racemization ratios in the human femur for age estimation.
    Journal of forensic sciences, 1998, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Age Determination by Skeleton; Aged; Aged, 80 and over; Aging; Aspartic Acid; Chr

1998
In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging.
    Magnetic resonance in medicine, 1999, Volume: 41, Issue:2

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reso

1999
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study.
    NMR in biomedicine, 1999, Volume: 12, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Female;

1999
Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.
    Neuroreport, 1999, Mar-17, Volume: 10, Issue:4

    Topics: Adenosine; Aging; Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Male; Microdialysis; N

1999
Changes in the amount of D-aspartic acid in the human femur with age.
    Growth, development, and aging : GDA, 1998,Winter, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Female; Femur; Humans; Male

1998
Aging of the adult human brain: in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy.
    Journal of magnetic resonance imaging : JMRI, 1999, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Humans; Magnet

1999
MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain.
    Magnetic resonance in medicine, 1999, Volume: 41, Issue:4

    Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Choline; Creatine;

1999
Developmental sex differences in amino acid neurotransmitter levels in hypothalamic and limbic areas of rat brain.
    Neuroscience, 1999, Volume: 90, Issue:4

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; gamma-Aminobutyric Acid; Gluta

1999
The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.
    Experimental neurology, 1999, Volume: 157, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antibodies; Aspartic Acid; Autopsy; Biomar

1999
Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Müller cell glutamate transporter GLAST.
    Cell and tissue research, 1999, Volume: 297, Issue:1

    Topics: Aging; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-B

1999
1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
    Magnetic resonance in medicine, 1999, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metab

1999
Favourable effect of K, Mg aspartate on serum proteins in aging rats.
    Mechanisms of ageing and development, 1999, May-03, Volume: 108, Issue:2

    Topics: Aging; Alpha-Globulins; Animals; Aspartic Acid; Blood Protein Electrophoresis; Haptoglobins; Immunoe

1999
Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures.
    Developmental neuroscience, 1999, Volume: 21, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High P

1999
Evaluation of aspartic acid racemization ratios in the human femur for age estimation.
    Journal of forensic sciences, 1999, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Age Determination by Skeleton; Aged; Aged, 80 and over; Aging; Aspartic Acid; Eva

1999
D-amino acid formation induced by a chiral field within a human lens protein during aging.
    Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Crystallins; Humans; Lens, Crystalline; Models, Chemi

1999
Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Nov-01, Volume: 19, Issue:21

    Topics: Aging; Animals; Aspartic Acid; Benzothiadiazines; Cerebellum; Dicarboxylic Acids; Electric Stimulati

1999
Formation of four isomers at the asp-151 residue of aged human alphaA-crystallin by natural aging.
    Biochemical and biophysical research communications, 1999, Nov-30, Volume: 265, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Crystallins; Humans; In Vitro Techniques; Infa

1999
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
    Brain research. Developmental brain research, 1999, Dec-10, Volume: 118, Issue:1-2

    Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic

1999
Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.
    The Biochemical journal, 2000, Feb-01, Volume: 345 Pt 3

    Topics: Adult; Aged; Aging; Animals; Aspartic Acid; Biomarkers; Bone and Bones; Bone Diseases, Metabolic; Bo

2000
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development.
    NMR in biomedicine, 1999, Volume: 12, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chloroform; Creatine; gamma-Aminobutyric Acid

1999
Adult and fetal haemoglobin J-Sardegna [alpha50(CE8)His-->Asp]: functional and molecular modelling studies.
    The Biochemical journal, 2000, Feb-15, Volume: 346 Pt 1

    Topics: 2,3-Diphosphoglycerate; Adult; Aging; Amino Acid Substitution; Arginine; Aspartic Acid; Binding Site

2000
Age-related changes in the D-aspartic acid content of the teeth of the senescence-accelerated mouse.
    Archives of oral biology, 2000, Volume: 45, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Body Temperature; Female; Incisor; Male; Mice; Mice, Inbred Strains;

2000
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
    Magnetic resonance imaging, 2000, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I

2000
In vitro high resolution proton magnetic resonance study of human cerebellar development during the period from the fetus to childhood.
    Physiological chemistry and physics and medical NMR, 1999, Volume: 31, Issue:2

    Topics: Aging; Amino Acids; Aspartic Acid; Cerebellum; Child; Child, Preschool; Creatinine; Dipeptides; Embr

1999
Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats.
    Neuroreport, 2000, Aug-03, Volume: 11, Issue:11

    Topics: Adenosine; Age Factors; Aging; Animals; Aspartic Acid; Glutamic Acid; Male; Neostriatum; Neurons; Ne

2000
D-aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release.
    Neuroscience, 2000, Volume: 100, Issue:1

    Topics: Acetylcholine; Adrenal Glands; Aging; Aminooxyacetic Acid; Animals; Animals, Newborn; Aspartic Acid;

2000
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absor

2000
Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis.
    Mechanisms of ageing and development, 2000, Nov-15, Volume: 119, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Cells, Cultured; Female; Hematopoiesis; Hematopoietic Stem Cells; Mag

2000
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex

2000
Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes.
    NeuroImage, 2000, Volume: 12, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Cognition; Energy Metabolism; Female; Frontal Lobe; H

2000
Chemical mapping of anxiety in the brain of healthy humans: an in vivo 1H-MRS study on the effects of sex, age, and brain region.
    Human brain mapping, 2000, Volume: 11, Issue:4

    Topics: Adult; Aging; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Female; Frontal Lobe; Humans; Magnetic

2000
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectrosco

2001
Development and aging of the cerebrum: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Ch

2001
Neurotransmitter contents in the retina of RCS rat.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:12

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; gamma-

2000
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
    Magnetic resonance in medicine, 2001, Volume: 45, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline;

2001
A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations.
    Cerebral cortex (New York, N.Y. : 1991), 2001, Volume: 11, Issue:7

    Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Choline; Creatinine; Frontal Lobe; Humans; M

2001
Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats.
    Neurochemistry international, 2001, Volume: 39, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cadmium; Corpus Striatum; Glutamic Acid; Glutamine; Hypo

2001
[Determination of the D-and L-forms of aspartic acid in intervertebral disk tissue as an indicator of age].
    Soudni lekarstvi, 2001, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Forensic Medicine; Humans; Interve

2001
[Determination of D- and L- forms of aspartic acid in Achilles tendon tissue as an indicator of age].
    Soudni lekarstvi, 2001, Volume: 46, Issue:2

    Topics: Achilles Tendon; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Forensic Medicine

2001
Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy.
    Neuroradiology, 2001, Volume: 43, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Corpus Striatum; Dementia; Female; Frontal L

2001
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio

2001
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex;

2001
Determination of free aspartic acid enantiomers in rat brain by capillary electrophoresis with laser-induced fluorescence detection.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Oct-05, Volume: 762, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Electrophoresis, Capillary; Lasers; Rats; Sp

2001
Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body.
    The Journal of comparative neurology, 2001, Oct-22, Volume: 439, Issue:3

    Topics: Aging; Animals; Antibody Specificity; Aspartic Acid; Axons; Body Patterning; Brain; Cell Size; Excit

2001
Inversion and isomerization of Asp-58 residue in human alphaA-crystallin from normal aged lenses and cataractous lenses.
    Biochimica et biophysica acta, 2001, Oct-18, Volume: 1549, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Infant; Isomeri

2001
Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice.
    Hippocampus, 2001, Volume: 11, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Cognition; Cognition Disorders; Epilepsy; Isomerism; Long-Term Potent

2001
Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats.
    Brain research. Developmental brain research, 2002, Jan-31, Volume: 133, Issue:1

    Topics: Aging; Aminooxyacetic Acid; Animals; Aspartic Acid; Excitatory Amino Acids; Female; Follicle Stimula

2002
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:5

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorder

2001
Effect of K, MG aspartate on some biological parameters of aging rats.
    Archives italiennes de biologie, 2002, Volume: 140, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Blood Proteins; Complement C3; Gamma Rays; Haptoglobins; Hemopexin; I

2002
Developmental delay in children: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:5

    Topics: Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities;

2002
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
    Neural plasticity, 2001, Volume: 8, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St

2001
Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins.
    The Journal of nutrition, 2002, Volume: 132, Issue:6

    Topics: Age Factors; Aging; Animals; Aspartic Acid; Folic Acid; Folic Acid Deficiency; Isoaspartic Acid; Liv

2002
Possible role of glutamate, aspartate, glutamine, GABA or taurine on cadmium toxicity on the hypothalamic pituitary axis activity in adult male rats.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2002, Volume: 15, Issue:2

    Topics: Administration, Oral; Aging; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cadmium; gamma-Am

2002
The presence of D-beta-aspartic acid-containing peptides in elastic fibers of sun-damaged skin: a potent marker for ultraviolet-induced skin aging.
    Biochemical and biophysical research communications, 2002, Jun-28, Volume: 294, Issue:5

    Topics: Aged; Aging; Aspartic Acid; Biomarkers; Child; D-Aspartic Acid; Elastic Tissue; Face; Humans; Immuno

2002
Isolation and identification of urinary beta-aspartyl dipeptides and their concentrations in human urine.
    Journal of biochemistry, 1978, Volume: 84, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dipeptides; Female; Glutamates; Glycine; Human

1978
Neoplastic transformation-linked alterations in adenylosuccinate synthetase activity.
    Biochemical and biophysical research communications, 1975, Sep-16, Volume: 66, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Inosine N

1975
Glutamine-dependent asparagine synthetase in fetal, adult and neoplastic rat tissues.
    Enzyme, 1975, Volume: 19, Issue:5-6

    Topics: Aging; Animals; Animals, Newborn; Aspartate-Ammonia Ligase; Aspartic Acid; Enzyme Activation; Fetus;

1975
Aspartic acid racemization in heavy molecular weight crystallins and water insoluble protein from normal human lenses and cataracts.
    Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Cataract; Child; Child, Preschool; Crystallins; Human

1978
Rapid method for the assay of 4-aminobutyric acid (GABA), glutamic acid and aspartic acid in brain tissue and subcellular fractions.
    Journal of chromatography, 1979, Apr-11, Volume: 162, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, Ion Exchange; Chromatography,

1979
Plasma aspartate levels in rats following administration of monopotassium aspartate via three routes.
    The Journal of toxicological sciences, 1979, Volume: 4, Issue:4

    Topics: Administration, Oral; Aging; Amino Acids; Animals; Aspartic Acid; Glutamates; Injections, Intraperit

1979
A radiochemical assay for N-acetyl-L-aspartate amidohydrolase (EC 3.5.1.15) and its occurrence in the tissues of the chicken.
    Life sciences, 1978, Aug-28, Volume: 23, Issue:8

    Topics: Aging; Amidohydrolases; Animals; Aspartic Acid; Chickens; Kidney; Male; Nervous System; Tissue Distr

1978
On the etiology of aging.
    Journal of theoretical biology, 1977, Jul-07, Volume: 67, Issue:1

    Topics: Aging; Amino Acids; Aspartic Acid; Half-Life; Humans; Isomerism; Phenylalanine; Proteins; Thermodyna

1977
Aspartic acid racemisation in the human lens during ageing and in cataract formation.
    Nature, 1977, Jul-07, Volume: 268, Issue:5615

    Topics: Aging; Aspartic Acid; Cataract; Humans; Lens, Crystalline; Stereoisomerism

1977
Considerations on the role of aspartic acid racemization in the aging process.
    Gerontology, 1977, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dental Enamel; Dentin; Erythrocytes; Humans; M

1977
Aspartic acid racemisation in dentine as a measure of ageing.
    Nature, 1976, Jul-22, Volume: 262, Issue:5566

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Body Temperature; Child; Dental Enamel; Dentin; Human

1976
Metabolism of glutamate and related amino acids in the 10-day-old mouse brain: experiments with labelled acetate and beta-hydroxybutyrate.
    Journal of neurochemistry, 1976, Volume: 27, Issue:6

    Topics: Acetates; Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon Radioisotopes;

1976
Aspartic acid racemization in tooth enamel from living humans.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:8

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dental Enamel; Humans; Mathematics; Middle Age

1975
Pyrimidine biosynthesis and its regulation in the developing rat brain.
    Journal of neurochemistry, 1976, Volume: 26, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Azauridine; Bicarbonates; Brain; Female; Fetus; Mal

1976
[3H]D-aspartic acid release in brain slices of adult and aged Fischer 344 rates.
    Neurochemical research, 1992, Volume: 17, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Brain; Calcium Channels; Electric Stimulation; Hippocampus; Kainic Ac

1992
Age-related changes in binding to excitatory amino acid uptake site in temporal cortex of human brain.
    Brain research. Developmental brain research, 1992, Feb-21, Volume: 65, Issue:2

    Topics: Aging; Amino Acids; Aspartic Acid; Humans; In Vitro Techniques; Infant; Infant, Newborn; Kinetics; R

1992
Age-related changes in binding to excitatory amino acid uptake sites in human cerebellum.
    Brain research, 1992, May-08, Volume: 579, Issue:2

    Topics: Aged; Aging; Amino Acids; Aspartic Acid; Autoradiography; Cerebellar Cortex; Cerebellum; Child, Pres

1992
Regional distribution of glutamate and aspartate in adult and old human brain.
    Brain research, 1992, Oct-30, Volume: 594, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Hum

1992
Age-specific development of malate-aspartate shuttle in the liver and kidney of mice.
    Biochemistry international, 1992, Volume: 27, Issue:6

    Topics: Aging; Animals; Aspartate Aminotransferases; Aspartic Acid; Kidney; Liver; Malate Dehydrogenase; Mal

1992
On the accumulation of D-aspartate in elastin and other proteins of the ageing aorta.
    Atherosclerosis, 1992, Volume: 97, Issue:2-3

    Topics: Aged; Aging; Amino Acids; Aorta; Aspartic Acid; Collagen; Elastin; Humans; Male; Middle Aged

1992
Ischemia does not induce the release of excitotoxic amino acids from the hippocampus of newborn rats.
    Brain research. Developmental brain research, 1991, Jun-21, Volume: 60, Issue:2

    Topics: Aging; Allopurinol; Animals; Animals, Newborn; Aspartic Acid; Brain Ischemia; Free Radicals; Glutama

1991
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
    Neuroscience letters, 1991, Oct-28, Volume: 132, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;

1991
Characterization of microcarrier cultures of neurons and astrocytes from cerebral cortex and cerebellum.
    Neurochemical research, 1991, Volume: 16, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cerebellum; Cerebral Cortex; Culture Te

1991
In vivo 1H and 31P NMR spectroscopy of the developing rat brain.
    Magnetic resonance in medicine, 1992, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Hy

1992
Age-dependent deamidation of the major intrinsic polypeptide from lens membranes.
    Current eye research, 1991, Volume: 10, Issue:9

    Topics: Aging; Amino Acid Sequence; Animals; Aquaporins; Asparagine; Aspartic Acid; Cattle; Chromatography,

1991
N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development.
    Developmental neuroscience, 1991, Volume: 13, Issue:6

    Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Injections, Intraventricu

1991
Postnatal development of the excitatory amino acid system in visual cortex of the rat. Changes in uptake and levels of aspartate and glutamate.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Visual C

1990
Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:7

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic

1990
Neuroexcitatory plasma amino acids are elevated in migraine.
    Neurology, 1990, Volume: 40, Issue:10

    Topics: Adult; Aging; Aspartic Acid; Female; Glutamates; Glutamic Acid; Headache; Humans; Male; Middle Aged;

1990
Brain development: 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods.
    Neurochemical research, 1990, Volume: 15, Issue:10

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Li

1990
Glycine administration decreases hepatic taurine content in mice.
    Biochemistry international, 1990, Volume: 22, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Glycine; Liver; Male; Mice; Myocardium; Taurine; Ti

1990
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:1

    Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co

1990
Changes in excitatory amino acid modulation of phosphoinositide metabolism during development.
    Brain research. Developmental brain research, 1990, Jan-01, Volume: 51, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Brain; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Phosphati

1990
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
    Brain research. Developmental brain research, 1990, Jan-01, Volume: 51, Issue:1

    Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles;

1990
Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.
    Radiology, 1990, Volume: 176, Issue:2

    Topics: Adenosine Triphosphate; Adolescent; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; F

1990
Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors.
    Endocrinology, 1990, Volume: 127, Issue:2

    Topics: Aging; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Gonadotro

1990
Age-related changes in uptake and release on L-[3H]noradrenaline in brain slices of senescence accelerated mouse.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; In Vitro Techniques; Male; Mice; Mice, I

1990
Changes in metabolite transport by small intestine and kidney of young and old rats.
    Mechanisms of ageing and development, 1990, Mar-15, Volume: 52, Issue:2-3

    Topics: Aging; Animals; Aspartic Acid; Citrates; Citric Acid; Glucose; In Vitro Techniques; Intestine, Small

1990
Site-specific racemization in aging alpha A-crystallin.
    FEBS letters, 1990, Aug-20, Volume: 269, Issue:1

    Topics: Aging; Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Cr

1990
D-aspartic acid in purified myelin and myelin basic protein.
    Biochemical and biophysical research communications, 1986, Mar-13, Volume: 135, Issue:2

    Topics: Adult; Aged; Aging; Animals; Aspartic Acid; Brain Chemistry; Cattle; Humans; Infant; Middle Aged; Mu

1986
N-methyl-aspartic acid lesions of the arcuate nucleus in adult C57BL/6J mice: a new model for age-related lengthening of the estrous cycle.
    Neuroendocrinology, 1989, Volume: 50, Issue:5

    Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Biogenic Monoamines; Body Weight; Es

1989
Whole-cell voltage-clamp recordings in granule cells acutely isolated from hippocampal slices of adult or aged rats.
    Neuroscience letters, 1989, Jan-02, Volume: 96, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Calcium; Cell Separation; Cells, Cultured; Electric Stimulation; Hipp

1989
Anoxia on slow inward currents of immature hippocampal neurons.
    Journal of neurophysiology, 1989, Volume: 62, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium Channels; Electric Conductivity; Hippocampu

1989
Transient increase of NMDA-binding sites in human hippocampus during development.
    Neuroscience letters, 1989, Apr-24, Volume: 99, Issue:1-2

    Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant,

1989
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1989, Volume: 7, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol

1989
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
    Science (New York, N.Y.), 1989, Nov-03, Volume: 246, Issue:4930

    Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methyl

1989
Purification and characterization of a protein containing D-aspartic acid in bovine lens.
    Biochimica et biophysica acta, 1989, Dec-21, Volume: 999, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Cattle; Chromatography; Crystallins; Electrophoresis, Polyacrylamide

1989
Protein carboxyl methyltransferase activity specific for age-modified aspartyl residues in mouse testes and ovaries: evidence for translation during spermiogenesis.
    Gamete research, 1989, Volume: 22, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Female; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Ovary

1989
Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids.
    Neurochemical research, 1989, Volume: 14, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Brain Stem; Cerebellar Cortex; Cerebral Cortex;

1989
Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices.
    British journal of pharmacology, 1985, Volume: 85, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cyclic GMP; Diffusion; Female; Glutamate

1985
Aspartate metabolism in rats during aging.
    Experimental gerontology, 1985, Volume: 20, Issue:3-4

    Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glut

1985
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type.
    Annals of neurology, 1986, Volume: 19, Issue:3

    Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic

1986
[Aspartate aminotransferase activity high affinity (3H) glutamate/(3H) aspartate uptake in rat nervous tissue in postnatal development].
    Acta histochemica. Supplementband, 1986, Volume: 33

    Topics: Aging; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspartic Acid; Autoradiography; Gangl

1986
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
    Annals of neurology, 1986, Volume: 20, Issue:5

    Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid;

1986
Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging.
    Gerontology, 1988, Volume: 34, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; gamma-Aminobutyric Acid; Glutamates; Glu

1988
L-aspartate and L-glutamate binding sites in developing normal and 'nervous' mutant mouse cerebellum.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:5-6

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cerebellum; Female; Glutamates; Gl

1987
Transient increased density of NMDA binding sites in the developing rat hippocampus.
    Brain research, 1988, Oct-04, Volume: 461, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hip

1988
Racemization of aspartyl residues in proteins from normal and cataractous human lenses: an aging process without involvement in cataract formation.
    Experimental eye research, 1989, Volume: 48, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cataract; Crystallins; Humans; Isomerism; Lens

1989
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
    Neuroscience, 1986, Volume: 17, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methyla

1986
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.
    Brain research, 1988, Aug-30, Volume: 459, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Hippocampus; Microinjections; N-Methylaspartate; Neu

1988
Changes in voltage dependence of NMDA currents during development.
    Neuroscience letters, 1988, Nov-22, Volume: 94, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Electric Conductivity; Hippocampus; In Vitro Techniques; Membrane Pot

1988
Solvent extraction clean-up for pre-treatment in amino acid analysis by gas chromatography. Application to age estimation from the D/L ratio of aspartic acid in human dentine.
    Journal of chromatography, 1988, Sep-30, Volume: 449, Issue:1

    Topics: Adult; Aging; Amino Acids; Aspartic Acid; Chromatography, Gas; Chromatography, Ion Exchange; Dentin;

1988
Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus.
    Brain research, 1988, Feb-01, Volume: 466, Issue:2

    Topics: Action Potentials; Aging; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techni

1988
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
    Life sciences, 1988, Volume: 42, Issue:18

    Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing

1988
D-aspartic acid in aged mouse skin and lens.
    Journal of radiation research, 1987, Volume: 28, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Lens, Crystalline; Mice; Skin; Whole-Body Irradiation

1987
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
    Brain research, 1987, Dec-01, Volume: 433, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane P

1987
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
    Neuroscience letters, 1986, Aug-29, Volume: 69, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Pot

1986
D-amino acid in irradiated and aged mouse.
    Journal of radiation research, 1986, Volume: 27, Issue:2

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cataract; Crystallins; Male; Mice; Mice, Inbred Strains;

1986
Characterization of a protein containing D-aspartic acid in aged mouse lens.
    Biochemical and biophysical research communications, 1987, Aug-14, Volume: 146, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Crystallins; Lens, Crystalline; Male; Mice; Mice, Inbred

1987
D-aspartate in human brain.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain; Brain Di

1987
Plasma glutamate concentrations in 1-year-old infants and adults ingesting monosodium L-glutamate in consommé.
    Pediatric research, 1986, Volume: 20, Issue:1

    Topics: Administration, Oral; Adult; Aging; Aspartic Acid; Erythrocytes; Female; Glutamates; Humans; Infant;

1986
Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: effect of thyroid hormones.
    Neurochemical research, 1985, Volume: 10, Issue:5

    Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cell Membrane; Kinetics; Osmolar Concent

1985
Regional changes in amino acid content in developing rat brain.
    Journal of neurochemistry, 1974, Volume: 23, Issue:5

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Ch

1974
Properties of heparan sulphate and chondroitin sulphate from young and old human aortae.
    The Biochemical journal, 1969, Volume: 114, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Aorta, Thoracic; Aspartic Acid; Chondroitin; Chromatogr

1969
Cytomorphometry of developing rat liver and its application to enzymic differentiation.
    The Journal of cell biology, 1972, Volume: 52, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Cell Count; Female; Glucagon; Glucokinase; Glucosyltransferases; Glyc

1972
Proceedings: Age-dependent interaction of potassium magnesium aspartate during general anesthesia. A contribution to lactate-pyruvate- and ATP-metabolism.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1974, Volume: 355, Issue:10

    Topics: Adenosine Triphosphate; Adult; Aging; Anesthesia, General; Aspartic Acid; Drug Interactions; Female;

1974
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
    Mechanisms of ageing and development, 1973, Volume: 1, Issue:5

    Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomyci

1973
Effect of cortisol treatment on free amino acid levels in rats.
    The Journal of endocrinology, 1973, Volume: 59, Issue:1

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Glycine; Hydrocortisone; Liver; Male; Muscle Pr

1973
Effect of undernutrition on amino acid compartimentation in the developing rat brain.
    Journal of neurochemistry, 1974, Volume: 22, Issue:4

    Topics: Aging; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Body Weight; Brain; Carbon Radioisotopes

1974
Free amino acids in developing rat retina.
    Journal of neurochemistry, 1974, Volume: 22, Issue:6

    Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Di

1974
The metabolism of (14C) glucose by the brains of suckling rats intoxicated with inorganic lead.
    Journal of neurochemistry, 1974, Volume: 22, Issue:4

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Body Weight; Brain; Carbon Radioisotopes;

1974
[Aortic elastin and its variations during senescence and arteriosclerosis].
    Pathologie-biologie, 1970, Volume: 18, Issue:1

    Topics: Aging; Amino Acids; Animals; Aorta; Arginine; Arteriosclerosis; Aspartic Acid; Cattle; Elastin; Glut

1970
The subunit structure of alpha-crystallin. Isolation and characterization of the S-carboxymethylated acidic subunits from adult and embryonic origin.
    European journal of biochemistry, 1969, Volume: 11, Issue:3

    Topics: Aging; Alkylation; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Chromatography, Ion

1969
Effects of dietary vitamin B 6 on the utilization of monosodium glutamate by rats.
    The Journal of nutrition, 1972, Volume: 102, Issue:7

    Topics: Aging; Alanine; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspart

1972
The isolation and partial characterization of age-correlated oligo-deoxyribo-ribonucleotides with covalently linked aspartyl-glutamyl polypeptides.
    Johns Hopkins medical journal. Supplement, 1972, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel;

1972
Biosynthesis of collagen fibres.
    Clinical science, 1970, Volume: 38, Issue:2

    Topics: Aging; Aspartic Acid; Collagen; Galactose; Glucose; Glutamates; Glycoproteins; Lysine; Proline

1970
Composition and formation of the insoluble protein fraction in the ocular lens.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1970, Volume: 5, Issue:2

    Topics: Aging; Albumins; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Crystallins; Electrophoresis; Huma

1970
Factors affecting incorporation of precursors into body constituents: a review of common sense considerations with glycolipids as examples.
    Lipids, 1970, Volume: 5, Issue:5

    Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebrosides; Galactose; Gangliosides; Glucos

1970
[Nitrogen metabolism in albino rat brain mitochondria during aging].
    Voprosy biokhimii mozga, 1970, Volume: 6

    Topics: Adenosine Diphosphate; Aging; Ammonia; Animals; Aspartic Acid; Brain; Glutamates; Malonates; Mitocho

1970
The uptake of amino acids by particulate fractions from brain.
    Biochimica et biophysica acta, 1969, Volume: 173, Issue:3

    Topics: Aging; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartic Acid; Biological Transport,

1969
Changes with age in the utilization of glucose carbon in liver and brain.
    Journal of neurochemistry, 1966, Volume: 13, Issue:12

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon; Carbon Isotopes; Centri

1966