Page last updated: 2024-08-17

aspartic acid and Acute Confusional Senile Dementia

aspartic acid has been researched along with Acute Confusional Senile Dementia in 280 studies

Research

Studies (280)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (8.21)	18.7374
1990's	59 (21.07)	18.2507
2000's	93 (33.21)	29.6817
2010's	83 (29.64)	24.3611
2020's	22 (7.86)	2.80

Authors

Authors	Studies
Bohsali, A; Crosson, B; Fleischer, CC; Goldstein, F; Hone-Blanchet, A; John, SE; Krishnamurthy, LC; Lah, J; Levey, A; Lin, Q; Loring, D; Qiu, D; Shahid, S; Zhao, L	1
Cordato, DJ; Shad, KF; Soubra, W	1
Slavov, N; Specht, H	1
Deng, L; Gao, H; Qian, S; Qing, G; Wang, C; Wang, X; Zhang, X; Zhong, M	1
Dacorro, L; Fingerhut, H; Gozdas, E; Gu, M; Hinkley, L; Hosseini, SMH; Hurd, R; Sacchet, MD	1
Futai, E; Hidaka, M; Ogawa, T; Suzuki, R; Takahashi, H; Yoshida, C	1
He, J; He, Y; Li, M; Liu, M; Sun, Z; Yang, J	1
Armstrong, DW; Dhaubhadel, U; Patel, A; Readel, ER	1
Cao, B; Feng, WS; Hao, FX; Jiao, XM; Liang, XW; Zeng, MN; Zheng, XK	1
Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S	1
Aguilar-Pineda, JA; Barazorda-Ccahuana, HL; Gómez, B; Paredes-Rosan, CA; Valencia, DE	1
Armstrong, DW; Du, S; Readel, ER; Wey, M	1
Atiya, S; Bartha, R; Borrie, MJ; Brymer, C; Fogarty, J; Montero-Odasso, M; Pasternak, SH; Wong, D	1
Bie, B; Foss, JF; Naguib, M; Wu, J	1
James, GA; Padala, KP; Padala, PR; Samant, RS	1
Kashiwaya, Y; King, MT; Pawlosky, RJ; Veech, RL	1
Ambasta, RK; Gupta, R; Kumar, P	1
Calabresi, P; Casamassa, A; Errico, F; Eusebi, P; Gaetani, L; Homma, H; Katane, M; Mancini, A; Miroballo, M; Nisticò, R; Nuzzo, T; Parnetti, L; Usiello, A	1
Aguirre, GK; Changolkar, L; Darwich, NF; Gibbons, GS; Grossman, M; He, Z; Irwin, DJ; Kim, B; Lee, EB; Luk, KC; Massimo, L; McMillan, CT; Nasrallah, IM; Nguyen, AT; O'Rourke, CM; Papageorgiou, SG; Papatriantafyllou, JD; Phan, JM; Porta, S; Suh, E; Toro, C; Van Deerlin, VM	1
Altiné-Samey, R; Antier, D; Balageas, AC; Beaufils, E; Chalon, S; Dufour-Rainfray, D; Emond, P; Foucault-Fruchard, L; Mavel, S	1
Mauri, M; Piubelli, L; Pollegioni, L; Princiotta Cariddi, L; Rabattoni, V; Sacchi, S; Versino, M	1
Murtas, G; Piubelli, L; Pollegioni, L; Rabattoni, V	1
Krause, BJ; Kuhla, A; Lindner, T; Müller, L; Power Guerra, N; Rühlmann, C; Stenzel, J; Teipel, S; Vollmar, B	1
Alon, A; Kruse, AC; Martin, SF; Sahn, JJ; Schmidt, HR; Wood, MD	1
Hadlich, S; Krause, BJ; Kuhla, A; Lindner, T; Polei, S; Rühlmann, C; Teipel, SJ; Vollmar, B	1
Dhanabalan, AK; Gunasekaran, K; Kesherwani, M; Velmurugan, D	1
Gong, QY; Gu, GJ; Guo, Y; Liu, JH; Wang, MY; Xu, JR; Zhang, B; Zhang, Q; Zhang, W	1
Moriya, M; Nojo, T; Waragai, M	1
Chen, CS; Huang, MF; Jaw, TS; Kuo, KC; Kuo, YT; Li, CW; Liu, TL; Yang, YH; Yeh, YC	1
Robertson, DS	1
Fujii, N; Ha, S; Isoyama, M; Kim, I; Kinouchi, T; Suzuki, M; Takata, T	1
Evgen'ev, MB; Kechko, OI; Kozin, SA; Makarov, AA; Mitkevich, VA; Rezvykh, AP; Serebryakova, MV; Vinokurov, MG; Yurinskaya, MM; Zatsepina, OG	1
Cao, L; Liang, Y; Liu, Y; Wan, W; Xu, Y; Zhu, C	1
Kulpanovich, A; Tal, A	1
Chang, TY; Hsiao, IT; Huang, CC; Huang, CY; Huang, KL; Lin, KJ; Liu, CH; Weng, YC; Yen, TC	1
Adzhubei, AA; Anashkina, AA; Barykin, EP; Garifulina, AI; Hollmann, M; Kasheverov, IE; Kozin, SA; Kruykova, EV; Makarov, AA; Mitkevich, VA; Shelukhina, IV; Spirova, EN; Tsetlin, VI	1
Boyer, DR; Cascio, D; Clarke, SG; Eisenberg, DS; Gonen, T; Richards, LS; Sawaya, MR; Warmack, RA; Zee, CT	1
Adair, JC; Gasparovic, C; Huisa, B; Prestopnik, J; Rosenberg, GA; Schrader, R; Taheri, S; Thompson, J	1
Kantarci, K	1
Bittner, DM; Heinze, HJ; Kaufmann, J	1
Andrade-Valença, LP; Menezes, TL; Valença, MM	1
Wang, X; Xu, L	1
Derreumaux, P; Li, MS; Ngo, ST; Nguyen, PH; Viet, MH	1
Fuh, JL; Hung, CW; Lirng, JF; Tsai, CF; Wang, SJ	1
Balayssac, S; Déjean, S; Francés, B; Gilard, V; Halley, H; Lalande, J; Lassalle, JM; Malet-Martino, M; Martino, R	1
Cadenas, E; Díaz Brinton, R; Kanamori, K; Patil, I; Ross, BD; Sancheti, H	1
Binder, LI; Garcia-Sierra, F; Jarero-Basulto, JJ; Kristofikova, Z; Luna-Muñoz, J; Mena, R; Perry, G; Ripova, D	1
Chen, CH; Chen, CS; Huang, MF; Kuo, YT; Lee, CC; Li, CW; Liu, GC; Liu, TL; Yeh, YC; Yen, CF	1
Chamberlain, R; Curran, GL; Garwood, M; Jack, CR; Kobayashi, D; Lin, JC; Marjańska, M; Poduslo, JF; Preboske, G; Weigand, SD; Wengenack, TM	1
Sugiki, T; Utsunomiya-Tate, N	1
Boeve, BF; Dickson, DW; Ferman, TJ; Graff-Radford, J; Gunter, J; Jack, CR; Kantarci, K; Knopman, DS; Lesnick, TG; Maroney-Smith, M; Murray, ME; Petersen, RC; Senjem, ML; Smith, GE; Tosakulwong, N	1
Chen, J; Chen, X; Fang, Y; Hou, L; Huang, G; Liu, S; Luo, X; Mu, N; Ning, Y; Shen, Z; Shi, H; Tan, Y; Wu, R; Zhang, H; Zhang, Y; Zheng, D; Zhong, X	1
Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M	1
Kumar, S	1
Alvarez-Linera, J; Frank, A; García-Álvarez, R; Hernández-Tamames, JA; Loureiro, JP; Mato Abad, V; Quirós, A	1
Horiguchi, J; Inagaki, T; Inami, Y; Kawamukai, T; Miyaoka, T; Okazaki, S; Shinno, H; Utani, E	2
Sukying, C; Suriyajakryuththana, W; Teepprasarn, N; Tuntiyatorn, L	1
Amann, M; Babb, JS; Gass, A; Glodzik, L; Gokhale, A; Gonen, O; Hirsch, JG; Monsch, AU; Rusinek, H; Sollberger, M	1
Chen, XG; Lei, XJ; Wang, MJ; Zou, JX	1
Bartha, R; Borrie, MJ; Penner, J; Wells, JL; Woolmore-Goodwin, SM	1
Boeve, BF; Dickson, DW; Gunter, JL; Jack, CR; Kantarci, K; Knopman, DS; Lesnick, TG; Liesinger, AM; Murray, ME; Parisi, JE; Petersen, RC; Przybelski, SA; Spychalla, A; Zhang, B	1
Doert, A; Eckert, GP; Müller, WE; Pilatus, U; Zanella, F	1
Akiguchi, I; Shiino, A; Watanabe, T	3
Calderón-Garcidueñas, L; Jewells, V; Lin, W; Melo-Sánchez, G; Mora-Tiscareño, A; Mukherjee, PS; Rodríguez-Díaz, J; Styner, M; Torres-Jardón, R	1
Chang, XL; Jiang, T; Liu, Y; Tan, L; Wang, H; Wang, HF; Wang, WY; Yin, RH; Yu, JT	1
Cao, Y; Chen, W; Chen, X; Guo, Z; Hou, H; Li, J; Liu, X; Shen, Y; Wei, F; Zhang, J	1
Cheglakov, IB; Kozin, SA; Kukharsky, MS; Kulikova, AA; Makarov, AA; Ovchinnikov, RK	1
Drosos-Ramirez, JC; Gueto-Tettay, C; Pestana-Nobles, R	1
Blennow, K; Hansson, O; Minthon, L; Strandberg, O; Sundgren, PC; Voevodskaya, O; Wahlund, LO; Westman, E; Zetterberg, H	1
Mably, AJ; Rowan, MJ; Walsh, DM; Zhang, D	1
Chen, W; Chen, X; Guo, Z; Hou, H; Liu, X; Shen, Y; Wei, F	1
Blamire, AM; Hayes, L; He, J; O'Brien, JT; Su, L; Watson, R	1
Dong, ZX; Gu, T; Li, NG; Lu, YT; Sun, Y; Wu, WY; Yu, SP; Zhong, Y	1
Archakov, AI; Kozin, SA; Makarov, AA; Nikolaev, EN; Popov, IA; Tsvetkov, PO	1
Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S	1
den Hollander, JA; Griffith, HR; Marson, DC; O'Brien, T; Okonkwo, OC; Watts, RL	1
Cooper, A; Daly, E; Foy, C; Glover, A; Hye, A; Lovestone, S; Murphy, D; Simmons, A; Thambisetty, M	1
Li, K; Wang, Z; Yu, L; Zhao, C; Zhou, W	1
Frölich, L; Kratzsch, T; Lais, C; Lanfermann, H; Maurer, K; Pantel, J; Pilatus, U; Rochmont, Adu M; Zanella, FE	1
Block, W; Ende, G; Frölich, L; Gür, O; Hammen, T; Heun, R; Jahn, H; Jessen, F; Kölsch, H; Kornhuber, J; Kucinski, T; Maier, W; Träber, F; Wiltfang, J	1
Chi, CW; Lee, HC; Lin, KN; Liu, HC; Liu, TY; Ping, YH; Wang, CH; Wang, PN	1
Fung, EY; Yang, H; Zubarev, AR; Zubarev, RA	1
Bredesen, DE; Koo, EH; Park, SA; Shaked, GM	1
Foniok, T; Grieb, P; Jasiński, A; Kirk, D; Labak, M; Rushforth, D; Tomanek, B	1
Bartha, R; Borrie, MJ; Penner, J; Rupsingh, R; Smith, M; Wells, JL	1
Errea, JM; Fayed, N; Modrego, PJ; Pina, MA; Rios, C; Sarasa, M	1
Coppel, Y; Dorlet, P; Faller, P; Guillon, E; Hureau, C; Sabater, L; Sayen, S; Solari, PL	1
Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S	1
Gruner, M; Jennings, G; Klafki, HW; Knölker, HJ; Linning, P; Schieb, H; Schlechtingen, G; Weidlich, S; Wiltfang, J	1
Daly, EM; Foy, CM; Glover, A; Lovestone, S; Murphy, DG; O'Gorman, R; Simmons, A	1
Dolan, PJ; Jin, YN; Johnson, GV; Quintanilla, RA	1
Archer, N; Beacher, F; Daly, E; Foy, CML; Lamar, M; Lovestone, S; Morris, RG; Murphy, DGM; Murphy, KC; Poppe, M; Prasher, V; Simmons, A	1
Chen, K; Ding, B; Fang, Y; Li, X; Ling, H; Wang, T; Xiao, S	1
Lyutvinskiy, Y; Soininen, H; Yang, H; Zubarev, RA	1
Arlt, S; Block, W; Ende, G; Frölich, L; Gür, O; Hammen, T; Jessen, F; Kornhuber, J; Kucinski, T; Lewczuk, P; Maier, W; Peters, O; Popp, J; Träber, F; Wiltfang, J	1
Binder, LI; García-Sierra, F; Jarero-Basulto, JJ; Kristofikova, Z; Majer, E; Ripova, D	1
Aguilar, K; Fayed, N; Modrego, PJ; Rojas-Salinas, G	1
Adamson, M; Ashford, JW; Beale, T; Fairchild, JK; Hernandez, B; La, D; Noda, A; O'Hara, R; Rosen, A; Spielman, D; Yesavage, JA	1
Cuellar-Baena, S; Dahlberg, C; Denisov, V; Hall, H; In't Zandt, R; Kirik, D	1
Barcikowska, M; Ćwikła, JB; Gabryelewicz, T; Walecki, J	1
Forster, DM; James, MF; Williams, SR	1
Andreiuolo, PA; Bottino, CM; de Oliveira-Souza, R; Moll, J; Silveira de Souza, A; Tovar-Moll, F	1
Fayed, N; Modrego, PJ	1
Asano, T; Hasegawa, M; Hata, K; Hisanaga, S; Saito, T; Shahpasand, K; Shibata, K; Toyoshima, Y; Uemura, I	1
Aebischer, P; Cacquevel, M; Cudalbu, C; Gruetter, R; Janssens, S; Lei, H; Mlynárik, V; Schneider, BL; Sun-Reimer, L	1
Choi, JY; Hong, YH; Kim, HS; Lim, TS; Moon, SY	1
Chang, WH; Chang, YJ; Chen, WT; Chen, YR; Cheng, CY; Cheng, IH; Hong, CJ; Hsieh, YF; Huang, HT; Liao, JY; Lin, YT; Liu, HC	1
Choi, JY; Hong, YH; Kim, HS; Lee, HY; Lim, TS; Moon, SY	1
Cai, Q; Chen, SQ; Shen, YY; Teng, GJ; Wang, PJ; Zang, FC; Zhang, W	1
Melø, TM; Nilsen, LH; Saether, O; Sonnewald, U; Witter, MP	1
Algarzae, N; Hebron, M; Miessau, M; Moussa, CE	1
Cai, K; Crescenzi, R; Hariharan, H; Haris, M; Kogan, F; Nath, K; Reddy, R; Singh, A	1
Gao, XL; Li, MH; Li, P; Wang, GL; Wang, PJ; Zhang, W	1
Alia, A; Nabuurs, RJ; Natté, R; van Buchem, MA; van Duijn, S; van Duinen, SG	1
Cynis, H; Güttler, BH; Ludwig, HH; Porzel, A; Schilling, S; Seifert, F	1
Firbank, MJ; Harrison, RM; O'Brien, JT	1
Capell, A; Edbauer, D; Ertl, M; Haass, C; Kaether, C; Lammich, S; Rietdorf, J; Steiner, H	1
Benedetti, C; Catani, M; Cherubini, A; Howard, R; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Senin, U; Tarducci, R	1
Block, W; Flacke, S; Jessen, F; Pohl, C; Schild, H; Träber, F	1
Fukuda, H; Izumiyama, N; Murayama, S; Shimizu, T; Shirasawa, T	1
Cheng, LL; Gonzalez, RG; Hyman, BT; Mallory, AE; Newell, K	1
Catani, M; Cherubini, A; Gobbi, G; Mecocci, P; Pelliccioli, G; Petrillo, SM; Piccirilli, M; Sciarma, T; Senin, U; Tarducci, R	1
Bacher, R; Kemmler, G; Lingg, A; Marksteiner, J; Vonbank, H; Weiss, U	1
Baslow, MH; Berg, MJ; Bhakoo, KK; Duff, K; Gaynor, K; Marks, N; Matsuoka, Y; Saito, M; Suckow, RF	1
Gonen, O	1
Boeve, BF; Edland, SD; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; Petersen, RC; Reynolds, G; Smith, GE; Tangalos, EG	1
Rai, GS; Waldman, AD	1
Abraha, A; Berry, RW; Binder, LI; Chen, F; Cryns, VL; Fu, Y; Gamblin, TC; Garcia-Sierra, F; Guillozet, AL; Lagalwar, S; LaPointe, N; Lu, M; Miller, R; Zambrano, A	1
Amend, DL; Capizzano, AA; Chui, HC; Du, AT; Jagust, WJ; Kramer, JH; Miller, BL; Norman, D; O'Neill, J; Reed, BR; Schuff, N; Weiner, MW; Yaffe, K	1
Dodd, PR; Scott, HL; Westphalen, RI	1
Charles, HC; Doraiswamy, PM; Ieni, JR; Krishnan, KR; Mintzer, J; Perdomo, C; Rogers, S; Weisler, R; Yu, X	1
Ito, H; Kizu, O; Nishimura, T; Yamada, K	1
Jones, RS; Waldman, AD	1
Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD	1
Ahn, KH; Cohen, BM; Frederick, BD; Kim, MJ; Lyoo, IK; Renshaw, PF; Satlin, A; Yurgelun-Todd, DA	1
Jacobsen, H; Künnecke, B; Loetscher, H; Metzger, F; Ozmen, L; Richards, JG; Steiner, G; von Kienlin, M	1
Berry, RW; Bigio, EH; Binder, LI; Cahill, ME; Fu, Y; Garcia-Sierra, F; Guillozet-Bongaarts, AL; Horowitz, PM; Reynolds, MR; Wang, T	1
Hancu, I; Hurd, RE; Sailasuta, N; Zimmerman, EA	1
Fayed, N; Modrego, PJ; Pina, MA	1
Benedetti, B; Bozzali, M; Comi, G; Falini, A; Filippi, M; Franceschi, M; Gambini, A; Magnani, G; Mossini, R; Pero, G; Scotti, G	1
Ntais, C; Polycarpou, A	1
Campo, P; Fernández, A; Fernández, S; García-Segura, J; Gil-Gregorio, P; Maestú, F; Montoya, J; Ortiz, T; Portera, A; Viaño, J	1
Block, W; Freymann, N; Heun, R; Jessen, F; Maier, W; Schild, HH; Traeber, F	1
Cammisa, G; D'Aniello, A; D'Aniello, E; Fisher, G; Migliaccio, N; Spinelli, P	1
Cavalcanti, JL; Engelhardt, E; Laks, J; Moreira, DM	1
Allinquant, B; Madeira, A; Pommet, JM; Prochiantz, A	1
Kuret, J; Yin, H	1
Azevedo, D; Bazzarella, MC; Bottino, CM; Castro, CC; Hototian, SR; Tatsch, M	2
Abe, K; Hattori, N; Mihara, M; Sakoda, S; Sawada, T	1
Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR	1
Ataie, M; Banwait, S; Bredesen, DE; Carlson, E; Chevallier, N; Galvan, V; Gorostiza, OF; Greenberg, DA; Jin, K; Logvinova, AV; Sagi, SA; Sitaraman, S	1
Bhattacharya, P; Harris, K; Lin, A; Ross, B; Tran, T; Wong, W	1
Boeve, BF; Gunter, J; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Reyes, D; Shiung, M; Smith, GE; Tangalos, EG; Weigand, SD	1
Block, W; Freymann, K; Jessen, F; Maier, W; Schild, HH; Traeber, F	1
Coppel, Y; Damian, L; Faller, P; Guilloreau, L; Mazarguil, H; Winterhalter, M	1
Fox, NC; Garrard, P; Hodges, JR; MacManus, DG; Schott, JM; Waldman, AD	1
Feng, F; Ge, QS; Hu, L; Jin, ZY; Li, ML; You, H; Yue, Y; Zuo, PP	1
Brockington, JC; Buchthal, SD; den Hollander, JA; Evanochko, WT; Griffith, HR; Harrell, LE; Marson, DC; Stewart, CC; Zamrini, EY	1
Karr, JW; Szalai, VA	1
Cheng, YH; Dong, YL; Ge, QS; Hong, X; Hu, L; Jiang, JM; Jin, ZY; Tian, QJ; Yue, Y; Zuo, PP	1
Bosch, B; Gómez-Ansón, B; Molinuevo, JL; Monte, GC; Rami, L; Sánchez-Valle, R; Villar, A	1
Kohara, N; Nakamoto, Y; Okada, T; Sakamoto, S; Senda, M	1
Banwait, S; Bredesen, DE; Galvan, V; Huang, W; Nguyen, TV; Tang, H; Zhang, J	1
Chang, W; Ghosh, AK; Hong, L; Koelsch, G; Kulkarni, S; Kumaragurubaran, N; Miller, HB; Reddy, DS; Tang, J; Turner, R; Weerasena, V; Xu, X	1
Li, S; Ma, X; Tan, S; Wang, B; Wang, J; Xie, YC; Yang, Z; Zheng, C; Zhou, S	1
Bartha, R; Borrie, MJ; Rupsingh, R; Rylett, J; Smith, M; Wells, JL	1
Ataie, M; Banwait, S; Bredesen, DE; Crippen, D; Galvan, V; Gorostiza, OF; Huang, W; Koo, EH; Zhang, J	1
Basurto-Islas, G; Binder, LI; García-Sierra, F; Guillozet-Bongaarts, AL; Luna-Muñoz, J; Mena, R	1
Ataie, M; Banwait, S; Bredesen, DE; Galvan, V; Gorostiza, OF; Huang, W; Tang, H; Zhang, J	1
Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC	1
Atack, JR; Blessed, G; Dodd, PR; Edwardson, JA; Fairbairn, AF; Hardy, JA; Perry, EK; Perry, RH; Tomlinson, BE	1
Blessed, G; Perry, EK; Perry, RH; Tarbit, I; Tomlinson, BE	1
Arias, C; Arrieta, I; Tapia, R	1
Constans, JM; Fein, G; Gerson, J; MacKay, S; Meyerhoff, DJ; Norman, D; Weiner, MW	1
Block, W; Fric, M; Keller, E; Kuhl, CK; Lamerichs, R; Möller, HJ; Rink, H; Schild, HH; Träber, F	1
Ross, BD; Shonk, T	1
Ball, MJ; Budinger, TF; Jagust, WJ; Kaye, JA; Kwo-On-Yuen, PF; Newmark, RD	1
Jaarsma, D; Korf, J; Veenma-van der Duin, L	1
Dodd, PR; Scott, HL; Tannenberg, AE	1
Fowler, AH; Husain, MM; Jolles, PR; Komoroski, RA; Liem, P; Mohanakrishnan, P; Vonsattel, JP	1
Asano, S; Endo, N; Furiya, Y; Ishii, K; Mori, H; Sahara, N; Shirasawa, T; Takio, K; Tomiyama, T	1
Christiansen, P; Henriksen, O; Schlosser, A	1
Dunlop, DS; Kenessey, A; Liu, WK; Yang, XR; Yen, SH	1
Costa, PT; Resnick, SM	1
Gifford, P; Izumi, J; Mandigo, JC; Michaelis, T; Moats, RA; Ross, BD; Shonk, TK	1
Constans, JM; Fein, G; MacKay, S; Meyerhoff, DJ; Norman, D; Van Dyke, C; Weiner, MW	1
Miulli, DE; Norwell, DY; Schwartz, FN	1
Asano, S; Endo, N; Furiya, Y; Mori, H; Shirasawa, T; Tomiyama, T	1
Bowen, DM; Francis, PT; Holmes, C; Procter, AW; Webster, MT	1
Akiguchi, I; Handa, J; Inubushi, T; Matsuda, M; Morikawa, S; Shiino, A	1
Horie, T; Isaki, K; Itoh, S; Kimura, H; Koshino, Y; Murata, I; Murata, T; Nishio, M; Omori, M; Umezawa, Y	1
Ball, MJ; Clarke, S; Cotter, RJ; Heinrikson, RL; Lowenson, JD; Reardon, IM; Roher, AE; Wang, R; Wolkow, C; Zürcher-Neely, HA	1
Ernst, T; Miller, BL; Moats, RA; Ross, BD; Shonk, T; Woolley, S	1
Coyle, JT; Tsai, G	1
Olney, JW; Schmidt, RE; Stewart, GR; Wozniak, DF	1
Chiarini, P; Gobbi, G; Lowenthal, DT; Palumbo, B; Palumbo, R; Parnetti, L; Pelliccioli, GP; Presciutti, O; Senin, U; Tarducci, R	1
Constans, JM; Fein, G; MacKay, S; Meyerhoff, DJ; Norman, D; Weiner, MW	1
Bardgett, ME; Csernansky, JG; Morris, JC; Olney, JW; Sheline, YI	1
Moats, RA; Shonk, T	1
Brooks, WM; Kattapong, VJ; Kodituwakku, PW; Rosenberg, GA; Wesley, MH	1
Aharon-Peretz, J; Chapman, J; Davidson, M; Friedman, E; Goldman, B; Korczyn, AD; Reznik-Wolf, H; St George Hyslop, PH; Treves, TA	1
Cribbs, DH; Poulos, TL; Tenner, AJ; Velazquez, P	1
Fowler, AH; Husain, MM; Jolles, PR; Komoroski, RA; Liem, P; Mohanakrishnan, P; Myers, L; Vonsattel, JP	1
Gawehn, J; Graf-Morgenstern, M; Heun, R; Schlegel, S; Stoeter, P; Tintera, J	1
Chang, L; Ernst, T; Mehringer, CM; Melchor, R	1
Frederick, BB; Renshaw, PF; Satlin, A; Yurgelun-Todd, DA	1
Furuya, S; Ide, M; Naruse, S	1
Carter, RE; Coyle, JT; Passani, LA; Vonsattel, JP	1
Amend, D; Ezekiel, F; Fein, G; Jagust, W; Kramer, JH; Mastrianni, JA; Norman, D; Schuff, N; Steinman, SK; Tanabe, J; Weiner, MW	1
Amend, DL; Fein, G; Meyerhoff, DJ; Norman, D; Schuff, N; Tanabe, JL; Weiner, MW	1
Bayer, S; Hennig, J; Langer, M; Laubenberger, J; Thiel, T	1
D'Aniello, A; Di Fiore, MM; Lee, JM; Petrucelli, L	1
Boyko, OB; Charles, HC; Erickson, R; Krishnan, KR; Lazeyras, F; Tupler, LA	1
Charles, HC; Doraiswamy, PM; Krishnan, KR	1
Ihara, Y; Takio, K; Watanabe, A	1
Akiyama, H; Arai, T; Ikeda, K; Kondo, H; Mori, H	1
Diehl, TS; Kimberly, WT; Ostaszewski, BL; Selkoe, DJ; Wolfe, MS; Xia, W	1
Fukuda, H; Mori, H; Nakajima, M; Shimizu, T; Shirasawa, T	1
Clarke, EE; Gervais, FG; Huang, J; LeBlanc, A; Nicholson, DW; Rigby, M; Robertson, GS; Roy, S; Ruffolo, SC; Shearman, MS; Smith, D; Thornberry, NA; Vaillancourt, JP; Van Der Ploeg, LH; Xanthoudakis, S; Xu, D; Zamboni, RJ; Zheng, H; Zhu, Y	1
Cotman, CW; Fonseca, MI; Head, E; Tenner, AJ; Velazquez, P	1
Clarke, S; Lowenson, JD; Roher, AE	1
Brand, M; Grünberg, J; Haass, C; Leimer, U; Lun, K; Romig, H; Walter, J	1
Benson, MD; Kluve-Beckerman, B; Liepnieks, JJ; Orpiszewski, J; Schormann, N	1
Arthur, JW; Dunbrack, RL; Sauder, JM	1
Adalsteinsson, E; Kleinhans, N; Pfefferbaum, A; Spielman, DM; Sullivan, EV	1
Boeve, BF; Campeau, NG; Ivnik, RJ; Jack, CR; Kantarci, K; Kokmen, E; O'Brien, PC; Petersen, RC; Smith, GE; Tangalos, EG; Xu, YC	1
Abrahám, I; Harkany, T; Kónya, C; Korf, J; Laskay, G; Luiten, PG; Nyakas, C; Penke, B; Sasvári, M; Sebens, JB; Soós, K; Timmerman, W; Tóth, B; Zarándi, M	1
Block, W; Flacke, S; Heun, R; Jessen, F; Keller, E; Lamerichs, R; Papassotiropoulos, A; Schild, HH; Träber, F	1
Mori, H; Ogawara, M; Shimizu, T; Shirasawa, T; Watanabe, A	1
Akahane, A; Hirasawa, H; Isse, K; Kato, N; Kobayashi, S; Kunugi, H; Nabika, T; Nanko, S; Otsuka, M; Ueki, A	1
Barboriak, DP; Charles, HC; Chen, JG; Doraiswamy, PM	1
Arawaka, S; Chen, F; Fraser, P; Haass, C; Holmes, E; Kawarai, T; Milman, P; Nishimura, M; Rogaeva, E; Song, YQ; St George-Hyslop, P; Steiner, H; Supala, A; Tandon, A; Yu, G; Zhang, DM	1
Alvarez-Arcaya, A; Berciano, J; Combarros, O; González-García, J; Llorca, J; Mateo, I; Sánchez-Guerra, M	1
Heindel, W; Heiss, WD; Kessler, J; Kugel, H; Mielke, R; Pietrzyk, U; Schopphoff, HH	1
Kaneko, I; Kubo, T; Morimoto, K	1
Cagiano, R; Cassano, T; Cuomo, V; Kendrick, KM; Pietra, C; Steardo, L; Tattoli, M; Trabace, L	1
Catani, M; Cherubini, A; Gobbi, G; Howard, R; Mecocci, P; Pelliccioli, GP; Piccirilli, M; Senin, U; Tarducci, R	1
Alexander, GE; Chang, L; Huang, W; Krasuski, JS; Rapoport, SI; Schapiro, MB; Shetty, HU	1
Fraser, P; George-Hyslop, PS; Honda, A; Imaizumi, K; Katayama, T; Kudo, T; Mori, K; Rozmahel, R; Takeda, M; Tohyama, M; Yoneda, T	1
Block, W; Flacke, S; Heun, R; Jessen, F; Keller, E; Lamerichs, R; Schild, HH; Träber, F	1
Condron, MM; Kirkitadze, MD; Teplow, DB	1
Blesa, R; Castellví, M; Gendre, J; Lleó, A; Oliva, R; Pastor, P; Queralt, R	1
Engelhardt, E; Laks, J; Marinho, VM; Moreira, DM; Oliveira, AC; Rozenthal, M	1
Iidaka, T; Itoh, H; Kado, H; Kimura, H; Kosaka, H; Murata, T; Omori, M; Wada, Y	1
Amend, DL; Capizzano, AA; Du, AT; Jagust, W; Kramer, J; Miller, B; Norman, D; O'Neill, J; Schuff, N; Weiner, MW; Wolkowitz, OM; Yaffe, K	1
Abe, K; Hattori, N; Sakoda, S; Sawada, T	1
Block, W; Flacke, S; Heun, R; Jessen, F; Keller, E; Lamerichs, R; Manka, C; Schild, H; Träber, F	1
Klunk, WE; McClure, RJ; Moossy, J; Panchalingam, K; Pettegrew, JW	1
Chávez, M; Cusano, GP; D'Aniello, A; Fisher, GH; Petrucelli, L; Vetere, A	1
Chou, SJ; Emory, C; Fisher, GH; Frey, WH; Man, EH; Payan, IL	1
Cerwinski, S; Chou, SJ; Emory, C; Fisher, GH; Frey, WH; Man, EH; Martin, T; Payan, IL	1
Cusano, GP; D'Aniello, A; Fisher, GH; Man, EH; Padula, L; Vetere, A	1
Bonham, JR; Candy, JM; Marshall, E; Perry, EK; Perry, RH; Xuereb, JH	1
Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T	1
Olney, JW	1
Brooks, DN; Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J	1
Cross, AJ; Deakin, JF; Perry, EK; Perry, RH; Royston, C; Simpson, M; Slater, P	1
Cross, AJ; Deakin, JF; Mann, DM; Royston, MC; Simpson, MD; Slater, P	1
Meldrum, B	1
Bowen, DM; Francis, PT; Neary, D; Smith, CC; Snowden, JS	1
De Boni, U; McLachlan, DR	1
Arai, H; Iizuka, R; Kanazawa, I; Kosaka, K; Muramoto, O; Sasaki, H	1
Cotman, CW; Geddes, JW	1
Beal, MF; Bird, ED; Ellison, DW; Martin, JB; Mazurek, MF	1
D'Amato, CJ; Greenamyre, JT; Penney, JB; Young, AB	1
Barton, A; Cowburn, R; Hardy, J; Lofdahl, E; O'Carroll, AM; Reynolds, G; Wester, P; Winblad, B	1
Bowen, DM; Carl, R; Francis, PT; Lowe, SL; Neal, JW; Pearson, A; Powell, TP; Stephens, PH	1
Bowen, DM; Murphy, E; Neary, D; Palmer, AM; Procter, AW	1
Briggs, R; Cowburn, R; Hardy, J; Roberts, P	2
Bowen, DM; Esiri, MM; Francis, PT; Hunt, A; Lowe, SL; Najlerahim, A; Palmer, AM; Patel, AJ; Procter, AW; Stratmann, GC	1
Cotman, CW; Monaghan, DT	1
Austin, GE; Mirra, SS; Shapira, R	1
Bowen, DM; Palmer, AM; Procter, AW; Stratmann, GC	1
Arends, G; Cadilla-Perezrios, R; Chemburkar, R; Fisher, GH; Frey, WH; Garcia, NM; Man, EH; Payan, IL	1

Reviews

14 review(s) available for aspartic acid and Acute Confusional Senile Dementia

Article	Year
The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease. Fundamental & clinical pharmacology, 2021, Volume: 35, Issue:3 Topics: Alanine; Alzheimer Disease; Animals; Arginine; Aspartic Acid; Biomarkers; Disease Models, Animal; Glutamic Acid; Humans; Metabolomics; Rats	2021
The Role of D-Amino Acids in Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2021, Volume: 80, Issue:2 Topics: Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Serine	2021
Proton MRS in mild cognitive impairment. Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:4 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; Diagnosis, Differential; Disease Models, Animal; Disease Progression; Energy Metabolism; Humans; Inositol; Magnetic Resonance Spectroscopy; Mice; Translational Research, Biomedical	2013
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD, 2015, Volume: 46, Issue:4 Topics: Alzheimer Disease; Aspartic Acid; Brain; Creatine; Databases, Bibliographic; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Protons	2015
Development and Structural Modification of BACE1 Inhibitors. Molecules (Basel, Switzerland), 2016, Dec-22, Volume: 22, Issue:1 Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Curcumin; Enzyme Inhibitors; Gene Expression; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Peptidomimetics; Piperazines; Structure-Activity Relationship; Terpenes	2016
A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. Dementia and geriatric cognitive disorders, 2002, Volume: 14, Issue:2 Topics: Alzheimer Disease; Aspartic Acid; Brain; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Parkinson Disease; Reference Values; Temporal Lobe	2002
1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurological research, 2004, Volume: 26, Issue:5 Topics: Acetylcholine; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Dementia, Vascular; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Neurons	2004
Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer's disease-- a meta-analysis. Journal of neurology, 2005, Volume: 252, Issue:10 Topics: Alleles; Alzheimer Disease; Asian People; Aspartic Acid; Case-Control Studies; Confidence Intervals; Gene Frequency; Genotype; Glutamic Acid; Homozygote; Humans; Models, Statistical; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Risk Factors; White People	2005
N-acetylaspartate in neuropsychiatric disorders. Progress in neurobiology, 1995, Volume: 46, Issue:5 Topics: Alzheimer Disease; Aspartic Acid; Brain; Neuropsychology	1995
Isoaspartate formation and neurodegeneration in Alzheimer's disease. Archives of biochemistry and biophysics, 2000, Sep-15, Volume: 381, Issue:2 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Aspartic Acid; Blood Vessels; Brain; Cerebrovascular Circulation; Humans; In Vitro Techniques; Isomerism; Mice; Mice, Knockout; Molecular Sequence Data; Nerve Degeneration; Plaque, Amyloid; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; tau Proteins	2000
Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate. Acta neurologica Scandinavica. Supplementum, 2000, Volume: 176 Topics: Aged; Alzheimer Disease; Aspartic Acid; Autopsy; Diagnosis, Differential; Humans; Magnetic Resonance Spectroscopy; Prognosis	2000
[Alzheimer's disease and magnetic resonance spectroscopy of the hippocampus]. Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Reproducibility of Results; Sensitivity and Specificity	2001
Excitotoxin-mediated neuron death in youth and old age. Progress in brain research, 1990, Volume: 86 Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases, Metabolic; Brain Injuries; Calcium Channels; Cell Survival; Central Nervous System; Central Nervous System Diseases; Food; Food Additives; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate	1990
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clinical science (London, England : 1979), 1985, Volume: 68, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats	1985

Trials

13 trial(s) available for aspartic acid and Acute Confusional Senile Dementia

Article	Year
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42. ACS chemical neuroscience, 2013, Nov-20, Volume: 4, Issue:11 Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Multiprotein Complexes; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Up-Regulation	2013
3.0 T MRI arterial spin labeling and magnetic resonance spectroscopy technology in the application of Alzheimer's disease. Experimental gerontology, 2014, Volume: 60 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circulation; Choline; Creatine; Female; Gyrus Cinguli; Humans; Imaging, Three-Dimensional; Magnetic Resonance Angiography; Magnetic Resonance Spectroscopy; Male; Middle Aged; Spin Labels	2014
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Data Collection; Dementia; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests; Protons; Residence Characteristics; Sensitivity and Specificity; Severity of Illness Index	2008
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differential; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Prospective Studies; Protons; Reproducibility of Results; Sensitivity and Specificity	2008
Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease. Progress in neuro-psychopharmacology & biological psychiatry, 2010, Feb-01, Volume: 34, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cholinesterase Inhibitors; Creatine; Female; Galantamine; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Neuropsychological Tests; Regression Analysis	2010
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy. European journal of neurology, 2010, Volume: 17, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Protons; Severity of Illness Index; Treatment Outcome	2010
MR spectroscopy for assessment of memantine treatment in mild to moderate Alzheimer dementia. Journal of Alzheimer's disease : JAD, 2011, Volume: 26 Suppl 3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Creatine; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Memantine; Neuropsychological Tests; Pilot Projects	2011
Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology, 2003, Aug-12, Volume: 61, Issue:3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Dementia, Vascular; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Predictive Value of Tests; Reference Values	2003
Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. The American journal of psychiatry, 2003, Volume: 160, Issue:11 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Neurons; Piperidines; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome	2003
High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease. Progress in neuro-psychopharmacology & biological psychiatry, 2008, Apr-01, Volume: 32, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cholinesterase Inhibitors; Creatine; Donepezil; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Piperidines; Protons	2008
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study. Dementia and geriatric cognitive disorders, 2008, Volume: 25, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Protons; Residence Characteristics	2008
Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology, 1995, Volume: 195, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases, Metabolic; Creatine; Dementia; Diagnosis, Differential; Double-Blind Method; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Sensitivity and Specificity	1995
In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes. Biological psychiatry, 1997, Jul-15, Volume: 42, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Parietal Lobe; Reference Values; Temporal Lobe	1997

Other Studies

253 other study(ies) available for aspartic acid and Acute Confusional Senile Dementia

Article	Year
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults. Neurobiology of aging, 2022, Volume: 109 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Peptide Fragments; tau Proteins	2022
The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2022, Volume: 85, Issue:1 Topics: Acoustic Stimulation; Afferent Pathways; Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Cerebral Cortex; Cognitive Dysfunction; Creatine; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status and Dementia Tests; Middle Aged; Temporal Lobe	2022
Beyond Protein Sequence: Protein Isomerization in Alzheimer's Disease. Journal of proteome research, 2022, 02-04, Volume: 21, Issue:2 Topics: Alzheimer Disease; Amino Acid Sequence; Aspartic Acid; Humans; Isomerism	2022
Aspartic Acid-Modified Phospholipids Regulate Cell Response and Rescue Memory Deficits in APP/PS1 Transgenic Mice. ACS chemical neuroscience, 2022, 07-20, Volume: 13, Issue:14 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Disease Models, Animal; Liposomes; Memory Disorders; Mice; Mice, Transgenic; Phospholipids; Plaque, Amyloid; Presenilin-1	2022
NeuroImage. Clinical, 2022, Volume: 36 Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition; Cognitive Dysfunction; Creatine; Glutamic Acid; Humans; Inositol; Proton Magnetic Resonance Spectroscopy	2022
Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production. International journal of molecular sciences, 2023, Feb-16, Volume: 24, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Humans; Mutation; Proline	2023
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2023, Volume: 94, Issue:1 Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; D-Aspartic Acid; Humans; Neurodegenerative Diseases; Phenylalanine; Proline; Tandem Mass Spectrometry	2023
Variable fragmentation and ionization of amyloid-beta epimers and isomers. Analytical and bioanalytical chemistry, 2023, Volume: 415, Issue:27 Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Humans; Isomerism; Peptide Fragments; Tandem Mass Spectrometry	2023
[Effect of aqueous extract of Corni Fructus on Aβ_(25-35)-induced brain injury and neuroinflammation in mice with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:15 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Brain Injuries; Cornus; Cysteine; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Docking Simulation; Neuroinflammatory Diseases; Peptide Hydrolases; Tumor Necrosis Factor-alpha	2023
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase. Biochimica et biophysica acta. General subjects, 2020, Volume: 1864, Issue:3 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothiazoles; Brain; Dioxolanes; Epilepsy; Humans; Isoaspartic Acid; Neurons; PC12 Cells; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Structure-Activity Relationship; Valproic Acid	2020
Amyloid beta oligomers: how pH influences over trimer and pentamer structures? Journal of molecular modeling, 2019, Dec-13, Volume: 26, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Histidine; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Dynamics Simulation; Peptide Fragments; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization	2019
Complete identification of all 20 relevant epimeric peptides in β-amyloid: a new HPLC-MS based analytical strategy for Alzheimer's research. Chemical communications (Cambridge, England), 2020, Feb-04, Volume: 56, Issue:10 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Chromatography, High Pressure Liquid; Humans; Serine; Stereoisomerism; Tandem Mass Spectrometry	2020
Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study. Journal of Alzheimer's disease : JAD, 2020, Volume: 73, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Diffusion Tensor Imaging; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Limbic System; Magnetic Resonance Spectroscopy; Male; Memory, Episodic; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Pilot Projects; White Matter	2020
Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses. Molecular neurobiology, 2020, Volume: 57, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; CA1 Region, Hippocampal; Ceftriaxone; Cognition Disorders; Complement C1q; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Microglia; Morris Water Maze Test; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phagocytosis; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Up-Regulation	2020
Improvement of neuronal integrity with methylphenidate treatment for apathy in Alzheimer's disease. International psychogeriatrics, 2020, Volume: 32, Issue:4 Topics: Affective Symptoms; Aged; Alzheimer Disease; Apathy; Aspartic Acid; Brain; Brain Chemistry; Central Nervous System Stimulants; Humans; Magnetic Resonance Spectroscopy; Male; Methylphenidate; Receptors, Dopamine; Treatment Outcome	2020
A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences, 2020, Feb-04, Volume: 21, Issue:3 Topics: Alzheimer Disease; Animals; Aspartic Acid; Brain; Citric Acid Cycle; Diet; Disease Models, Animal; Esters; Glucose; Glutamic Acid; Hippocampus; Ketone Bodies; Ketones; Ketosis; Male; Mice	2020
Identification of novel class I and class IIb histone deacetylase inhibitor for Alzheimer's disease therapeutics. Life sciences, 2020, Sep-01, Volume: 256 Topics: Alzheimer Disease; Aspartic Acid; Databases, Chemical; Drug Evaluation, Preclinical; Glycine; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Machine Learning; Molecular Docking Simulation; Molecular Structure; Molecular Targeted Therapy; Phenylalanine; Protein Isoforms; Pyrimidines; Thermodynamics; Zinc	2020
Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease. Biochimica et biophysica acta. Proteins and proteomics, 2020, Volume: 1868, Issue:12 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Brain; Female; Humans; Male; Organ Specificity; Postpartum Period; Prognosis; Serine; tau Proteins	2020
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.), 2020, 11-20, Volume: 370, Issue:6519 Topics: Alzheimer Disease; Animals; Aspartic Acid; Gene Knock-In Techniques; Genes, Dominant; Glycine; Humans; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Neurofibrillary Tangles; Phosphorylation; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Valosin Containing Protein	2020
Serum D-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker. Translational psychiatry, 2021, 01-26, Volume: 11, Issue:1 Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; Humans; Receptors, N-Methyl-D-Aspartate; Serine	2021
Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice. Nutrients, 2021, Mar-18, Volume: 13, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Autophagy; Calcium-Binding Proteins; Caloric Restriction; Cerebral Cortex; Creatine; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Hippocampus; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurons; Plaque, Amyloid; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals	2021
Identification of the gene that codes for the σ Proceedings of the National Academy of Sciences of the United States of America, 2017, 07-03, Volume: 114, Issue:27 Topics: Alzheimer Disease; Animals; Aspartic Acid; Carrier Proteins; Cattle; Cholesterol; Endoplasmic Reticulum; Gene Expression Regulation; Humans; Insecta; Intracellular Signaling Peptides and Proteins; Ligands; Liver; MCF-7 Cells; Membrane Glycoproteins; Membrane Proteins; Niemann-Pick C1 Protein; PC12 Cells; Protein Binding; Rats; Receptors, sigma; Recombinant Proteins; RNA, Small Interfering; Schizophrenia	2017
APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study. NeuroImage. Clinical, 2017, Volume: 15 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Creatine; Female; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Presenilin-1	2017
Identification of new BACE1 inhibitors using Pharmacophore and Molecular dynamics simulations approach. Journal of molecular graphics & modelling, 2017, Volume: 76 Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Catalytic Domain; Enzyme Inhibitors; Humans; Molecular Dynamics Simulation	2017
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice. Hippocampus, 2017, Volume: 27, Issue:12 Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Synapses	2017
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study. Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Gyrus Cinguli; Humans; Inositol; Lewy Body Disease; Male; Mental Status and Dementia Tests; Parkinson Disease; Prodromal Symptoms; Proton Magnetic Resonance Spectroscopy; Retrospective Studies; Risk Factors	2017
Association between altered neurochemical metabolites and apathy in patients with Alzheimer's disease. International psychogeriatrics, 2018, Volume: 30, Issue:5 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apathy; Aspartic Acid; Creatine; Female; Gyrus Cinguli; Humans; Linear Models; Male; Proton Magnetic Resonance Spectroscopy	2018
Proposed biochemistry of Parkinson's and Alzheimer's diseases. Medical hypotheses, 2017, Volume: 109 Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine; Lewy Bodies; Models, Biological; Parkinson Disease; Plaque, Amyloid; Pyruvaldehyde; Quinolinic Acid; Treatment Outcome	2017
Identification of ᴅ-amino acid-containing peptides in human serum. PloS one, 2017, Volume: 12, Issue:12 Topics: Adult; Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; Cataract; Chromatography, Liquid; Crystallins; Fibrinogen; Fibrinopeptide B; Humans; Middle Aged; Peptides; Proteomics; Tandem Mass Spectrometry; Young Adult	2017
Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation. Scientific reports, 2018, 02-23, Volume: 8, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Aspartic Acid; Cell Line, Tumor; Cell Survival; Electrophoresis, Gel, Two-Dimensional; Humans; Models, Biological; Neurons; Nuclear Matrix-Associated Proteins; Peptide Fragments; Phosphorylation; Phosphoserine; Protein Isoforms; Protein Processing, Post-Translational; RNA-Binding Proteins; tau Proteins; Tubulin	2018
Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Experimental cell research, 2018, 09-01, Volume: 370, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Caspases; Cell Line, Tumor; Epitopes; Humans; Neurons; Phosphorylation; tau Proteins	2018
The application of magnetic resonance fingerprinting to single voxel proton spectroscopy. NMR in biomedicine, 2018, Volume: 31, Issue:11 Topics: Adult; Alzheimer Disease; Artifacts; Aspartic Acid; Computer Simulation; Female; Gray Matter; Humans; Image Processing, Computer-Assisted; Models, Biological; Monte Carlo Method; Phantoms, Imaging; Proton Magnetic Resonance Spectroscopy; Young Adult	2018
Progress of Brain Amyloid Deposition in Familial Alzheimer's Disease with Taiwan D678H APP Mutation. Journal of Alzheimer's disease : JAD, 2018, Volume: 66, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Progression; Ethylene Glycols; Family Health; Female; Follow-Up Studies; Histidine; Humans; Male; Middle Aged; Positron-Emission Tomography; Taiwan	2018
Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity. Cells, 2019, 07-25, Volume: 8, Issue:8 Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Calcium; Cell Line, Tumor; Isomerism; Mice; Models, Molecular; Molecular Imaging; Neurons; Oocytes; Protein Binding; Structure-Activity Relationship	2019
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nature communications, 2019, 07-26, Volume: 10, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Humans; Isoaspartic Acid; Isomerism; Mutation; Protein Conformation	2019
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment. Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cognition Disorders; Creatine; Data Interpretation, Statistical; Dementia, Vascular; Executive Function; Female; Humans; Leukoaraiosis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Neuropsychological Tests; Regression Analysis	2013
Association of 1H-MR spectroscopy and cerebrospinal fluid biomarkers in Alzheimer's disease: diverging behavior at three different brain regions. Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:1 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Creatine; Female; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Neuroimaging; Parietal Lobe; Peptide Fragments; Sensitivity and Specificity; tau Proteins	2013
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging. Arquivos de neuro-psiquiatria, 2013, Volume: 71, Issue:4 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Diagnosis, Differential; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Male; Mental Status Schedule; Severity of Illness Index	2013
Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11? ACS chemical neuroscience, 2013, Nov-20, Volume: 4, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Glutamic Acid; Humans; Markov Chains; Models, Genetic; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Proteostasis Deficiencies; Structure-Activity Relationship; Zinc	2013
Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan, 2013, Volume: 23, Issue:3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Depression; Female; Gyrus Cinguli; Humans; Inositol; Male; Neuroimaging; Neuropsychological Tests; Prefrontal Cortex; Psychomotor Agitation	2013
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages. Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebellum; Cerebral Cortex; Disease Models, Animal; Genotype; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Metabolome; Mice; Mice, Transgenic; Tissue Extracts	2014
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Mice; Mice, Transgenic; Thioctic Acid; Vitamin B Complex	2014
Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology, 2013, Volume: 72, Issue:12 Topics: Aged, 80 and over; Alzheimer Disease; Amino Acid Chloromethyl Ketones; Aspartic Acid; Brain; Caspase 3; Female; Humans; Male; Microscopy, Electron; Molecular Weight; Neurofibrillary Tangles; Neurofibrils; Neuroprotective Agents; Oligopeptides; tau Proteins	2013
Altered neurochemical metabolites in Alzheimer's disease patients with unawareness of deficits. International psychogeriatrics, 2014, Volume: 26, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Awareness; Creatine; Dominance, Cerebral; Female; Frontal Lobe; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Prognosis; Reference Values	2014
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization. Neuroscience, 2014, Feb-14, Volume: 259 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Humans; Immunization, Passive; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Presenilin-1; Statistics, Nonparametric	2014
Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β. Biochemical and biophysical research communications, 2013, Nov-15, Volume: 441, Issue:2 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aspartic Acid; Cell Survival; Drug Design; Humans; Isomerism; Neurons; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats	2013
Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies. Neurobiology of aging, 2014, Volume: 35, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatine; Diagnosis, Differential; Female; Gyrus Cinguli; Hippocampus; Humans; Lewy Body Disease; Magnetic Resonance Spectroscopy; Male; Occipital Lobe	2014
1H-proton magnetic resonance spectroscopy differentiates dementia with Lewy bodies from Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2014, Volume: 40, Issue:4 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Chi-Square Distribution; Female; Glutamic Acid; Humans; Lewy Body Disease; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; ROC Curve	2014
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; Dementia; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Retrospective Studies; Tritium	2014
Comment re: Journal of the Neurological Sciences 260 (2007) 132-138, PMID 17540407. Journal of the neurological sciences, 2014, Aug-15, Volume: 343, Issue:1-2 Topics: Alzheimer Disease; Aspartic Acid; Female; Gyrus Cinguli; Humans; Inositol; Male	2014
The partial volume effect in the quantification of 1H magnetic resonance spectroscopy in Alzheimer's disease and aging. Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:3 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Cognitive Dysfunction; Female; Functional Laterality; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	2014
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. Journal of the neurological sciences, 2014, Aug-15, Volume: 343, Issue:1-2 Topics: Alzheimer Disease; Aspartic Acid; Female; Gyrus Cinguli; Humans; Inositol; Male	2014
Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Cross-Sectional Studies; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged	2014
Global N-acetylaspartate in normal subjects, mild cognitive impairment and Alzheimer's disease patients. Journal of Alzheimer's disease : JAD, 2015, Volume: 43, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Sensitivity and Specificity	2015
Reduced N-acetylaspartate to creatine ratio in the posterior cingulate correlates with cognition in Alzheimer's disease following four months of rivastigmine treatment. Dementia and geriatric cognitive disorders, 2015, Volume: 39, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cholinesterase Inhibitors; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Phenylcarbamates; Rivastigmine	2015
Early Alzheimer's disease neuropathology detected by proton MR spectroscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Dec-03, Volume: 34, Issue:49 Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Astrocytes; Biomarkers; Case-Control Studies; Early Diagnosis; Female; Functional Neuroimaging; Gray Matter; Gyrus Cinguli; Humans; Inositol; Male; Microglia; Neurofibrillary Tangles; Proton Magnetic Resonance Spectroscopy; Synaptic Vesicles; tau Proteins	2014
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy	2015
[Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy]. Rinsho shinkeigaku = Clinical neurology, 2015, Volume: 55, Issue:10 Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; Forecasting; Hippocampus; Humans; Male; Proton Magnetic Resonance Spectroscopy	2015
A Critical Proton MR Spectroscopy Marker of Alzheimer's Disease Early Neurodegenerative Change: Low Hippocampal NAA/Cr Ratio Impacts APOE ɛ4 Mexico City Children and Their Parents. Journal of Alzheimer's disease : JAD, 2015, Volume: 48, Issue:4 Topics: Adolescent; Adult; Air Pollution; Alzheimer Disease; Apolipoprotein E4; Aspartic Acid; Body Mass Index; Child; Cohort Studies; Creatine; Family; Female; Hippocampus; Humans; Male; Mexico; Prospective Studies; Proton Magnetic Resonance Spectroscopy; tau Proteins; Urban Population	2015
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study. BMC psychiatry, 2015, Dec-02, Volume: 15 Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Depressive Disorder; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy; Quality of Life	2015
Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice. Neurotoxicity research, 2016, Volume: 29, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Plaque, Amyloid; Presenilin-1	2016
Determination of the protonation state for the catalytic dyad in β-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study. Journal of molecular graphics & modelling, 2016, Volume: 66 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Catalysis; Catalytic Domain; Crystallography, X-Ray; Ethylamines; Hydrogen Bonding; Hydrogenation; Ligands; Molecular Dynamics Simulation; Protons	2016
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. Neurology, 2016, May-10, Volume: 86, Issue:19 Topics: Aged; Alzheimer Disease; Amyloidogenic Proteins; Apolipoprotein E4; Aspartic Acid; Brain; Brain Mapping; Choline; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Positron-Emission Tomography; Prodromal Symptoms; Prospective Studies; Sweden; tau Proteins	2016
Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cerebral cortex (New York, N.Y. : 1991), 2017, 07-01, Volume: 27, Issue:7 Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartate Aminotransferase, Cytoplasmic; Aspartic Acid; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Homeostasis; Humans; Injections, Intraperitoneal; Male; Oxaloacetic Acid; Peptide Fragments; Rats; Rats, Wistar; Synapses; Time Factors; Tumor Necrosis Factor-alpha	2017
(1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease. Comprehensive psychiatry, 2016, Volume: 69 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Dominance, Cerebral; Female; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy	2016
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. Translational psychiatry, 2016, 08-30, Volume: 6, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lewy Body Disease; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy	2016
Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide. Chembiochem : a European journal of chemical biology, 2008, Jul-02, Volume: 9, Issue:10 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Humans; Kinetics; Peptide Fragments; Zinc	2008
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2008, Volume: 4, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studies; Choline; Creatine; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Parkinson Disease	2008
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. Journal of neurology, 2008, Volume: 255, Issue:11 Topics: Aged; alpha-Macroglobulins; Alzheimer Disease; Aspartic Acid; Biomarkers; Complement Factor H; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Organ Size	2008
Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer disease. Acta radiologica (Stockholm, Sweden : 1987), 2009, Volume: 50, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Gyrus Cinguli; Hippocampus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged	2009
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy. Psychiatry research, 2009, Jul-15, Volume: 173, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Dementia; Disease Progression; Female; Follow-Up Studies; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Parietal Lobe; Prognosis; Severity of Illness Index	2009
A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. Neurology, 2009, May-19, Volume: 72, Issue:20 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognition Disorders; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Temporal Lobe	2009
Heteroplasmy of mitochondrial D310 mononucleotide repeat region in the blood of patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2009, Volume: 18, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Blood Cells; Cognition Disorders; DNA Mutational Analysis; DNA, Mitochondrial; Female; Humans; Male; Microsatellite Repeats; Middle Aged; Retrospective Studies; Young Adult	2009
Toward proteome-scale identification and quantification of isoaspartyl residues in biological samples. Journal of proteome research, 2009, Volume: 8, Issue:10 Topics: Alzheimer Disease; Aspartic Acid; Cell Line; Fourier Analysis; Humans; Isoaspartic Acid; Isomerism; Peptides; Protein Processing, Post-Translational; Proteins; Proteomics; Tandem Mass Spectrometry	2009
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochemical and biophysical research communications, 2009, Oct-16, Volume: 388, Issue:2 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Aspartic Acid; Cell Line, Tumor; Cytotoxins; Dipeptides; Mice; Molecular Sequence Data; Peptide Fragments; Protein Multimerization; Protein Structure, Tertiary; Rats	2009
Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer's disease. Acta neurochirurgica. Supplement, 2010, Volume: 106 Topics: Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Disease Models, Animal; Electrons; Glucose; Glutathione; Injections, Intraventricular; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Streptozocin	2010
Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH. Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:50 Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Binding Sites; Copper; Dipeptides; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy	2009
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging. Dementia and geriatric cognitive disorders, 2010, Volume: 30, Issue:1 Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Cognition Disorders; Diagnosis, Differential; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Prospective Studies	2010
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons. Journal of neuroscience research, 2010, Nov-01, Volume: 88, Issue:14 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles	2010
Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP. Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Dec-27, Volume: 16, Issue:48 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Cell Membrane; Chickens; Dose-Response Relationship, Drug; Eggs; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sequence Homology, Amino Acid	2010
Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment. Brain topography, 2011, Volume: 24, Issue:3-4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Protons	2011
Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiology of aging, 2012, Volume: 33, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Cell Line, Transformed; Down-Regulation; Humans; Mitochondria; Mitochondrial Diseases; Neurons; Primary Cell Culture; Prosencephalon; Rats; tau Proteins	2012
Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's disease. NeuroImage, 2011, Jul-01, Volume: 57, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Studies; Dementia; Down Syndrome; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged	2011
Using proton magnetic resonance spectroscopy to identify mild cognitive impairment. International psychogeriatrics, 2012, Volume: 24, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Female; Gyrus Cinguli; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Male; Neuroimaging	2012
Alzheimer's disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins. Journal of Alzheimer's disease : JAD, 2011, Volume: 27, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Blood Proteins; Cognitive Dysfunction; Female; Humans; Male; Mass Spectrometry; Sex Factors; Statistics, Nonparametric	2011
Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia. Journal of Alzheimer's disease : JAD, 2011, Volume: 27, Issue:2 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Dementia; Female; Humans; Male; Middle Aged; Mitochondria; Neurons; Peptide Fragments	2011
Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. Brain pathology (Zurich, Switzerland), 2012, Volume: 22, Issue:2 Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Apoptosis; Aspartic Acid; Humans; Mutation; Neurofibrillary Tangles; Peptide Fragments; tau Proteins; Ubiquitin	2012
Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy study. American journal of Alzheimer's disease and other dementias, 2011, Volume: 26, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Severity of Illness Index	2011
Magnetic resonance spectroscopic methods for the assessment of metabolic functions in the diseased brain. Current topics in behavioral neurosciences, 2012, Volume: 11 Topics: Alzheimer Disease; Aspartic Acid; Brain; Humans; Isotopes; Magnetic Resonance Spectroscopy; Parkinson Disease; Protons	2012
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI). Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:12 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe	2011
Effects of Alzheimer's disease transgenes on neurochemical expression in the mouse brain determined by ¹H MRS in vitro. NMR in biomedicine, 2012, Volume: 25, Issue:1 Topics: Alzheimer Disease; Analysis of Variance; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Glycerylphosphorylcholine; Humans; Inositol; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Transgenes	2012
Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease. Dementia and geriatric cognitive disorders, 2011, Volume: 32, Issue:5 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Creatine; Diagnosis, Differential; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Neuropsychological Tests; Parietal Lobe; Predictive Value of Tests; Reference Values; Temporal Lobe	2011
Longitudinal magnetic resonance spectroscopy as marker of cognitive deterioration in mild cognitive impairment. American journal of Alzheimer's disease and other dementias, 2011, Volume: 26, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cognitive Dysfunction; Creatine; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged	2011
Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Feb-15, Volume: 32, Issue:7 Topics: Alanine; Alzheimer Disease; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Chlorocebus aethiops; COS Cells; Female; Humans; Male; Mice; Microtubules; Mitochondria; Mutation; PC12 Cells; Phosphorylation; Protein Binding; Rats; tau Proteins	2012
Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2012, Volume: 31 Suppl 3 Topics: Adenosine Triphosphate; Algorithms; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Chemistry; Creatine Kinase; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphocreatine; Phosphorus; Protons	2012
Functional investigation of bilateral posterior cingulate gyri using multivoxel MR spectroscopy. European neurology, 2012, Volume: 67, Issue:5 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Creatine; Female; Functional Laterality; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Republic of Korea; Retrospective Studies; Statistics as Topic	2012
Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies. PloS one, 2012, Volume: 7, Issue:4 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aspartic Acid; Base Sequence; Cells, Cultured; Copper; Female; HEK293 Cells; Histidine; Humans; Middle Aged; Molecular Sequence Data; Mutation; Peptide Fragments; Polymerization; Taiwan; Zinc	2012
Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy. Dementia and geriatric cognitive disorders, 2012, Volume: 33, Issue:2-3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Disease Progression; Female; Gyrus Cinguli; Humans; Inositol; Intelligence Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Statistics as Topic	2012
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Disease Models, Animal; Functional Neuroimaging; Glutamic Acid; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Protons	2012
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study. Journal of neurochemistry, 2012, Volume: 123, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Female; Frontal Lobe; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Transgenic	2012
Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models. Neuroscience, 2012, Dec-06, Volume: 225 Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Atrophy; Brain; Carbon Isotopes; Carrier Proteins; Cell Cycle Proteins; Disease Models, Animal; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Eukaryotic Initiation Factors; Gene Knock-In Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Presenilin-1; Single-Blind Method; tau Proteins; TOR Serine-Threonine Kinases; Transcription Factors; Ubiquitin-Protein Ligases	2012
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. Journal of neuroscience methods, 2013, Jan-15, Volume: 212, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping; Choline; Creatine; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Neuroimaging; Presenilin-1; Tritium	2013
1H-MRS assessment of the therapeutic effect of bilateral intraventricular BDNF infusion into APP/PS1 double transgenic mice. Journal of molecular neuroscience : MN, 2013, Volume: 50, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Infusions, Intraventricular; Inositol; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Presenilin-1; Receptor, trkB	2013
Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy. Journal of Alzheimer's disease : JAD, 2013, Volume: 34, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Disease Models, Animal; Female; Glutamic Acid; Humans; Iron; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1	2013
A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues. Amino acids, 2013, Volume: 44, Issue:4 Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Isoaspartic Acid; Isomerism; Kinetics; Plaque, Amyloid; Protein Processing, Post-Translational	2013
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. The Journal of cell biology, 2002, Aug-05, Volume: 158, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Cell Compartmentation; Cell Membrane; Cells, Cultured; Endocytosis; Endopeptidases; Eukaryotic Cells; Green Fluorescent Proteins; Humans; Indicators and Reagents; Luminescent Proteins; Macromolecular Substances; Membrane Glycoproteins; Membrane Proteins; Mutagenesis, Site-Directed; Mutation; Presenilin-1; Protein Binding; Protein Transport; Receptors, Notch; Recombinant Fusion Proteins; Transfection	2002
Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. Journal of the American Geriatrics Society, 2002, Volume: 50, Issue:10 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine; Cross-Sectional Studies; Female; Humans; Hypertension; Inositol; Magnetic Resonance Spectroscopy; Male	2002
In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration. Amino acids, 2002, Volume: 23, Issue:1-3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neuron Disease; Protons	2002
Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease. Journal of neuroscience research, 2002, Nov-01, Volume: 70, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Blood Vessels; Brain; Female; Humans; Immunohistochemistry; Isomerism; Male; Microscopy, Electron; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid	2002
Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology. Magnetic resonance imaging, 2002, Volume: 20, Issue:7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studies; Choline; Creatine; Humans; In Vitro Techniques; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Neurons	2002
Axonal injury within language network in primary progressive aphasia. Annals of neurology, 2003, Volume: 53, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aphasia, Primary Progressive; Aspartic Acid; Axons; Creatine; Diagnosis, Differential; Female; Frontal Lobe; Humans; Language; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Temporal Lobe	2003
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy. The Journal of clinical psychiatry, 2003, Volume: 64, Issue:3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creatine; Dementia; Dementia, Vascular; Diagnosis, Differential; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Pick Disease of the Brain; Retrospective Studies; Temporal Lobe	2003
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte. Neuromolecular medicine, 2003, Volume: 3, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Brain Diseases; Cell Survival; Cells, Cultured; Disease Models, Animal; Down-Regulation; Fetus; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neuroglia; Neurons; Organ Culture Techniques; Rats; Synaptophysin; Water-Electrolyte Balance	2003
Higher field strength for proton MR spectroscopy. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Cognition Disorders; Creatinine; Humans; Inositol; Magnetic Resonance Spectroscopy	2003
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Female; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve	2003
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study. Neuroradiology, 2003, Volume: 45, Issue:8 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognition Disorders; Creatinine; Dementia, Vascular; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe	2003
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-19, Volume: 100, Issue:17 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Base Sequence; Binding Sites; Caspases; DNA, Complementary; Humans; In Vitro Techniques; Mice; Neurofibrillary Tangles; Neurons; Recombinant Proteins; Sequence Deletion; tau Proteins	2003
Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:9 Topics: Aged; Alzheimer Disease; Aspartic Acid; Binding Sites; Biological Transport; Cerebral Cortex; Down-Regulation; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Presynaptic Terminals; Radioligand Assay; Synaptic Membranes; Synaptic Vesicles; Tritium	2003
Posterior cingulate metabolic changes in frontotemporal lobar degeneration detected by magnetic resonance spectroscopy. Neuroradiology, 2004, Volume: 46, Issue:4 Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dementia; Diagnosis, Differential; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prognosis; Radiography	2004
1H MR spectroscopy in common dementias. Neurology, 2004, Oct-26, Volume: 63, Issue:8 Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dementia; Dementia, Vascular; Diagnosis, Differential; Down-Regulation; Female; Humans; Inositol; Lewy Body Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurodegenerative Diseases; Protons	2004
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders; Creatine; Dementia; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Mental Status Schedule; Protons; Temporal Lobe	2004
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiology of disease, 2005, Volume: 18, Issue:1 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-2; Spectrum Analysis	2005
Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiology of aging, 2005, Volume: 26, Issue:7 Topics: Alzheimer Disease; Antigens; Aspartic Acid; Blotting, Western; Brain; Fluorescent Antibody Technique; Gene Deletion; Humans; Models, Biological; Neurofibrillary Tangles; Phosphorylation; Postmortem Changes; Protein Processing, Post-Translational; tau Proteins	2005
1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's disease. Magnetic resonance in medicine, 2005, Volume: 53, Issue:4 Topics: Aged; Aged, 80 and over; Algorithms; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Chemistry; Case-Control Studies; Creatine; Diagnosis, Differential; Discriminant Analysis; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve	2005
Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. The American journal of psychiatry, 2005, Volume: 162, Issue:4 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Cohort Studies; Creatine; Female; Follow-Up Studies; Hippocampus; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Probability; Severity of Illness Index	2005
A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. NeuroImage, 2005, Jul-15, Volume: 26, Issue:4 Topics: Aged; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Reference Values	2005
Evidence of biochemical and biomagnetic interactions in Alzheimer's disease: an MEG and MR spectroscopy study. Dementia and geriatric cognitive disorders, 2005, Volume: 20, Issue:2-3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Chemistry; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetoencephalography; Male; Memory, Short-Term; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychomotor Performance	2005
A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease. Dementia and geriatric cognitive disorders, 2005, Volume: 20, Issue:2-3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Temporal Lobe	2005
Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients. Neuroscience letters, 2005, Nov-04, Volume: 388, Issue:1 Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alzheimer Disease; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Cerebrospinal Fluid; Female; Glutamic Acid; Glutamine; Humans; Lateral Ventricles; Male; Middle Aged; Reference Values; Transaminases; Up-Regulation	2005
Alzheimer's disease and proton magnetic resonance spectroscopy of limbic regions: a suggestion of a clinical-spectroscopic staging. Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:2A Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Animals; Aspartic Acid; Case-Control Studies; Creatine; Female; Humans; Limbic System; Magnetic Resonance Spectroscopy; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index	2005
SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:13 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Aspartic Acid; Biological Assay; Brain; Cell Death; Cell Line, Tumor; Cell Survival; Chromosomal Proteins, Non-Histone; Cytoplasm; DNA-Binding Proteins; Down-Regulation; Histone Chaperones; Humans; Immunohistochemistry; Mass Spectrometry; Models, Biological; Neurons; Oligonucleotides, Antisense; Peptides; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Silver Staining; Transcription Factors; Tyrosine	2005
C-terminal truncation modulates both nucleation and extension phases of tau fibrillization. FEBS letters, 2006, Jan-09, Volume: 580, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Caspases; Glutamic Acid; Humans; Membrane Proteins; Multiprotein Complexes; Protein Processing, Post-Translational	2006
[Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study]. Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognition Disorders; Creatine; Educational Status; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Protons	2005
Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia/Pick complex. Neuroreport, 2006, Mar-20, Volume: 17, Issue:4 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Mapping; Cerebral Cortex; Creatine; Dementia; Down-Regulation; Energy Metabolism; Female; Frontal Lobe; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parietal Lobe; Pick Disease of the Brain	2006
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. Journal of neurochemistry, 2006, Volume: 97, Issue:4 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspartic Acid; Binding Sites; Caspase 3; Caspases; Cerebral Cortex; Epitopes; Female; Humans; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Peptide Hydrolases; Phosphorylation; Serine; tau Proteins	2006
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proceedings of the National Academy of Sciences of the United States of America, 2006, May-02, Volume: 103, Issue:18 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Astrocytes; Behavior, Animal; Cell Proliferation; Cognition Disorders; Hippocampus; Humans; Maze Learning; Mice; Mice, Transgenic; Neurons; Point Mutation; Stem Cells	2006
Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Alzheimer Disease; Aspartic Acid; Brain; Canavan Disease; Child; Glutamic Acid; Humans; Magnetic Resonance Imaging; Molecular Structure; Schizophrenia	2006
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging, 2007, Volume: 28, Issue:9 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition Disorders; Creatine; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Retrospective Studies	2007
Treatment monitoring and response prediction with proton MR spectroscopy in AD. Neurology, 2006, Aug-08, Volume: 67, Issue:3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Monitoring, Ambulatory; Protons	2006
Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2006, Volume: 11, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Binding Sites; Copper; Humans; Peptide Fragments; Protein Binding; Spectrum Analysis; Thermodynamics; Tyrosine	2006
Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2006, Volume: 19, Issue:4 Topics: Aged; Alzheimer Disease; Aspartic Acid; Atrophy; Dementia; Diagnosis, Differential; Female; Frontal Lobe; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Middle Aged; Temporal Lobe	2006
Evaluation of neuroprotective effects of long-term low dose hormone replacement therapy on postmenopausal women brain hippocampus using magnetic resonance scanner. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2006, Volume: 21, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E3; Aspartic Acid; Creatine; Dose-Response Relationship, Drug; Estradiol; Estrogen Replacement Therapy; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Postmenopause; Progesterone; Testosterone	2006
Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease. NMR in biomedicine, 2007, Volume: 20, Issue:8 Topics: Aged; Alzheimer Disease; Aspartic Acid; Biopsy; Brain; Cognition Disorders; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Reference Values	2007
Role of aspartate-1 in Cu(II) binding to the amyloid-beta peptide of Alzheimer's disease. Journal of the American Chemical Society, 2007, Apr-04, Volume: 129, Issue:13 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Copper; Electron Spin Resonance Spectroscopy; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Peptide Fragments; Protein Binding; Temperature	2007
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition Disorders; Creatine; Down-Regulation; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mental Disorders; Neurocognitive Disorders; Neuropsychological Tests; Predictive Value of Tests; Up-Regulation	2007
Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes. Acta pharmacologica Sinica, 2007, Volume: 28, Issue:8 Topics: Aged; Alzheimer Disease; Apolipoproteins E; Aspartic Acid; Cognition; Creatinine; Cross-Sectional Studies; Estrogen Replacement Therapy; Genotype; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Postmenopause; Retrospective Studies	2007
Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease. Dementia and geriatric cognitive disorders, 2007, Volume: 24, Issue:4 Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cerebral Cortex; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Memory; Parietal Lobe; Protons; Psychological Tests; Severity of Illness Index; Temporal Lobe	2007
Reproducibility of magnetic resonance spectroscopy in correlation with signal-to-noise ratio. Psychiatry research, 2007, Nov-15, Volume: 156, Issue:2 Topics: Aged; Alzheimer Disease; Artifacts; Aspartic Acid; Choline; Creatine; Female; Gyrus Cinguli; Humans; Image Enhancement; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reproducibility of Results	2007
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. Journal of neurochemistry, 2008, Volume: 104, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Humans; Hydrolysis; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Transgenic; p21-Activated Kinases; Peptide Fragments; Point Mutation; Signal Transduction	2008
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3 Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Cricetinae; Cricetulus; Crystallography, X-Ray; Dipeptides; Drug Design; Female; Humans; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Sulfonamides	2008
Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese. Journal of molecular neuroscience : MN, 2008, Volume: 34, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Asian People; Aspartic Acid; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Nitric Oxide Synthase Type III; Polymorphism, Genetic	2008
C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2008, Volume: 13, Issue:1 Topics: Aged; Aged, 80 and over; Alcohol Oxidoreductases; Alzheimer Disease; Amyloid beta-Protein Precursor; Aspartic Acid; Cleavage Stimulation Factor; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Genes, Switch; Hippocampus; Humans; Male; Signal Transduction	2008
Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E4; Aspartic Acid; Brain; Disease Progression; Female; Genotype; Glutamic Acid; Humans; Immunohistochemistry; Male; Molecular Weight; Neurofibrillary Tangles; Peptide Hydrolases; Predictive Value of Tests; Protein Structure, Tertiary; Proteomics; Severity of Illness Index; tau Proteins	2008
Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behavioural brain research, 2008, Aug-22, Volume: 191, Issue:2 Topics: Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Maze Learning; Mental Disorders; Mice; Mice, Transgenic; Mutation; Reaction Time; Swimming	2008
Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. Brain research, 1983, Mar-28, Volume: 264, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Potassium; Temporal Lobe	1983
Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. Journal of neurochemistry, 1984, Volume: 42, Issue:5 Topics: Acetylcholinesterase; Alzheimer Disease; Aspartic Acid; Butyrylcholinesterase; Cerebral Cortex; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Reference Values	1984
Hippocampal free amino acids in Alzheimer's disease. Journal of neurochemistry, 1980, Volume: 35, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acids; Arginine; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Humans; Middle Aged	1980
beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices. Journal of neuroscience research, 1995, Jul-01, Volume: 41, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Calcium; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Rats; Rats, Wistar	1995
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia. Radiology, 1995, Volume: 197, Issue:2 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebral Ventricles; Choline; Creatine; Dementia; Dementia, Vascular; Female; Humans; Hydrogen; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurologic Examination	1995
[1H-MR spectroscopic imaging in patients with clinically diagnosed Alzheimer's disease]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 163, Issue:3 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Hippocampus; Humans; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Middle Aged; National Institutes of Health (U.S.); Occipital Lobe; Psychiatric Status Rating Scales; Temporal Lobe; United States	1995
Role of increased cerebral myo-inositol in the dementia of Down syndrome. Magnetic resonance in medicine, 1995, Volume: 33, Issue:6 Topics: Adolescent; Adult; Alzheimer Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Dementia; Down Syndrome; Humans; Inositol; Magnetic Resonance Spectroscopy; Middle Aged	1995
Brain N-acetyl-L-aspartic acid in Alzheimer's disease: a proton magnetic resonance spectroscopy study. Brain research, 1994, Dec-26, Volume: 667, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged	1994
N-acetylaspartate and N-acetylaspartylglutamate levels in Alzheimer's disease post-mortem brain tissue. Journal of the neurological sciences, 1994, Dec-20, Volume: 127, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Aspartic Acid; Brain Chemistry; Cerebellar Cortex; Chromatography, High Pressure Liquid; Dipeptides; Female; Hippocampus; Histamine H1 Antagonists; Humans; Male; Middle Aged; Olfactory Bulb; Spectrometry, Fluorescence	1994
Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Cerebral Cortex; Cysteic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Synaptic Membranes; Tissue Distribution; Tritium	1995
An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains. Experimental brain research, 1995, Volume: 102, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatinine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurofibrillary Tangles; Parietal Lobe; Temporal Lobe; Tomography, Emission-Computed, Single-Photon	1995
Racemization: its biological significance on neuropathogenesis of Alzheimer's disease. The Tohoku journal of experimental medicine, 1994, Volume: 174, Issue:3 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Biopolymers; Brain; Humans; Isomerism; Microscopy, Electron; Molecular Sequence Data; Nerve Degeneration; Nerve Tissue Proteins; Peptide Fragments; Protein Binding; Solubility; Spectrometry, Fluorescence; Stereoisomerism	1994
Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease. Magnetic resonance imaging, 1995, Volume: 13, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Phosphocreatine	1995
Detection of D-aspartate in tau proteins associated with Alzheimer paired helical filaments. Brain research, 1995, Mar-27, Volume: 675, Issue:1-2 Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Brain Chemistry; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hydrolysis; Immunoblotting; Neurofibrillary Tangles; Pregnancy; tau Proteins	1995
Comments on use of H-1 MR spectroscopy for diagnosis of probable Alzheimer disease. Radiology, 1995, Volume: 195, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Creatine; Humans; Inositol; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Sensitivity and Specificity	1995
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Annals of neurology, 1994, Volume: 36, Issue:1 Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged	1994
Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. The Journal of the American Osteopathic Association, 1993, Volume: 93, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminobutyrates; Aspartic Acid; Discriminant Analysis; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Humans; Ketoglutaric Acids; Male; Mass Screening; Middle Aged; Pilot Projects; Sensitivity and Specificity	1993
Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues. The Journal of biological chemistry, 1994, Apr-08, Volume: 269, Issue:14 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Humans; Molecular Sequence Data; Peptide Fragments; Stereoisomerism	1994
Relationship between beta-amyloid precursor protein, pyramidal neurones and astrocytes in human neocortex. Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Aspartic Acid; Biological Transport; Dementia; Electrophoresis, Polyacrylamide Gel; Frontal Lobe; Humans; Immunoblotting; Molecular Weight; Temporal Lobe	1993
Proton magnetic resonance spectroscopy with dementia. Surgical neurology, 1993, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatine; Dementia; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Protons; Reference Values	1993
In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome. Biological psychiatry, 1993, Sep-01, Volume: 34, Issue:5 Topics: Adult; Alzheimer Disease; Aspartic Acid; Brain; Cellular Senescence; Choline; Creatinine; Down Syndrome; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Synaptic Membranes	1993
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. The Journal of biological chemistry, 1993, Feb-15, Volume: 268, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Brain; Brain Chemistry; Centrifugation, Density Gradient; Cerebrovascular Circulation; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Humans; Meninges; Molecular Sequence Data; Muscle, Smooth, Vascular; Peptide Fragments; Peptides; Protein Processing, Post-Translational; Ultracentrifugation	1993
Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology, 1993, Volume: 187, Issue:2 Topics: Aged; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Parietal Lobe	1993
Mineralization of the globus pallidus following excitotoxic lesions of the basal forebrain. Brain research, 1995, Oct-09, Volume: 695, Issue:1 Topics: Alzheimer Disease; Animals; Aspartic Acid; Calcinosis; Cholinergic Fibers; Down Syndrome; Globus Pallidus; Male; Neurotoxins; Prosencephalon; Rats; Rats, Sprague-Dawley	1995
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease. Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:2 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Studies; Diagnosis, Differential; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon	1996
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging. Archives of neurology, 1996, Volume: 53, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischemia; Cerebral Cortex; Choline; Creatine; Cross-Sectional Studies; Dementia, Vascular; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Tissue; Phosphocreatine; Protons	1996
CSF excitatory amino acids and severity of illness in Alzheimer's disease. Neurology, 1996, Volume: 46, Issue:6 Topics: Aged; Alzheimer Disease; Aspartic Acid; Glutamine; Humans; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Taurine	1996
Evaluation of automated MR spectroscopy: application in Alzheimer disease. AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:9 Topics: Adult; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male	1995
Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia. Archives of neurology, 1996, Volume: 53, Issue:7 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Dementia, Vascular; Diagnosis, Differential; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	1996
A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis. Human genetics, 1996, Volume: 98, Issue:6 Topics: Alzheimer Disease; Aspartic Acid; Electrophoresis, Polyacrylamide Gel; Exons; Female; Glutamic Acid; Humans; Male; Membrane Proteins; Middle Aged; Pedigree; Presenilin-1; Seizures	1996
Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis. Nature medicine, 1997, Volume: 3, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Aspartic Acid; Binding Sites; Collagen; Humans; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Rats; Sequence Homology, Amino Acid	1997
Regional metabolic alterations in Alzheimer's disease: an in vitro 1H NMR study of the hippocampus and cerebellum. The journals of gerontology. Series A, Biological sciences and medical sciences, 1997, Volume: 52, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cadaver; Cerebellum; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurofibrillary Tangles; Neurons; Osmolar Concentration; Protons; Reference Values	1997
Proton magnetic resonance spectroscopy in dementia of Alzheimer type. International journal of geriatric psychiatry, 1997, Volume: 12, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Reference Values; Reproducibility of Results	1997
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Radiology, 1997, Volume: 203, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe	1997
[1H-MRSI of Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:7 Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	1997
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases. Molecular and chemical neuropathology, 1997, Volume: 31, Issue:2 Topics: Alzheimer Disease; Amino Acids; Antigens, Surface; Aspartic Acid; Brain; Case-Control Studies; Cell Count; Dipeptidases; Dipeptides; Glutamate Carboxypeptidase II; Humans; Huntington Disease; Neurons; Neuropeptides; Reference Values	1997
Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology, 1997, Volume: 49, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	1997
Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain. Radiology, 1998, Volume: 207, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Artifacts; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged	1998
[Clinical uses of proton magnetic resonance spectroscopy of the brain]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1998, Volume: 168, Issue:6 Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Diseases, Metabolic; Child; Choline; Creatine; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Rats	1998
Regional decreases of free D-aspartate levels in Alzheimer's disease. Neuroscience letters, 1998, Jul-03, Volume: 250, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Humans; Receptors, N-Methyl-D-Aspartate	1998
Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy. Psychiatry research, 1998, May-20, Volume: 82, Issue:2 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male	1998
Prediction of cognitive decline in early Alzheimer's disease. Lancet (London, England), 1998, Nov-21, Volume: 352, Issue:9141 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition; Disease Progression; Humans; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Prognosis; Reproducibility of Results	1998
Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. The Journal of biological chemistry, 1999, Mar-12, Volume: 274, Issue:11 Topics: Alzheimer Disease; Amides; Amino Acid Sequence; Aspartic Acid; Blotting, Western; Brain; Humans; Immune Sera; Immunohistochemistry; Mass Spectrometry; Microtubules; Molecular Sequence Data; Neurofilament Proteins; Protein Binding; Protein Isoforms; Protein Processing, Post-Translational; tau Proteins	1999
Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease. Brain research, 1999, Mar-27, Volume: 823, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Cerebral Cortex; Down Syndrome; Humans; Immunohistochemistry; Parkinson Disease; Tissue Distribution	1999
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature, 1999, Apr-08, Volume: 398, Issue:6727 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Cell Line; Cell Membrane; Cell-Free System; CHO Cells; Coenzymes; COS Cells; Cricetinae; Electrochemistry; Endopeptidases; Exons; Humans; Membrane Proteins; Microsomes; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Protein Folding; Recombinant Proteins; Transfection	1999
Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers. Bioorganic & medicinal chemistry letters, 1999, Apr-05, Volume: 9, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Cell Survival; Chromatography, High Pressure Liquid; Isomerism; Microscopy, Electron; Neurons; Peptide Fragments; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	1999
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell, 1999, Apr-30, Volume: 97, Issue:3 Topics: Acute Disease; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Amyloidosis; Animals; Apoptosis; Aspartic Acid; Aspartic Acid Endopeptidases; Brain Diseases; Camptothecin; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Enzyme Precursors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Situ Nick-End Labeling; Kainic Acid; Leukemia, Erythroblastic, Acute; Male; Mice; Mice, Inbred C57BL; Mutation; Neurons; Oligopeptides; Rabbits; Rats; Rats, Wistar; Sweden; Tumor Cells, Cultured	1999
The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Experimental neurology, 1999, Volume: 157, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antibodies; Aspartic Acid; Autopsy; Biomarkers; Brain; Down Syndrome; Entorhinal Cortex; Female; Frontal Lobe; Humans; Immunohistochemistry; Male; Mental Status Schedule; Middle Aged; Organ Specificity; Plaque, Amyloid; Regression Analysis	1999
Chemical modifications of deposited amyloid-beta peptides. Methods in enzymology, 1999, Volume: 309 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Humans; Molecular Sequence Data; Peptide Fragments; Polyglutamic Acid; Protein Isoforms; Sequence Homology, Amino Acid; Serine; Stereoisomerism	1999
Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry, 1999, Oct-12, Volume: 38, Issue:41 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Aspartic Acid; Cell Line; Conserved Sequence; Embryonic and Fetal Development; Female; Humans; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Protein Processing, Post-Translational; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Transfection; Zebrafish	1999
Protein aging hypothesis of Alzheimer disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:9 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Aspartic Acid; Biopolymers; Cyclization; Humans; Isomerism; Models, Biological; Models, Molecular; Molecular Sequence Data; Plaque, Amyloid; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Solubility; Succinimides; Thermodynamics; Time Factors	2000
Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase. Journal of molecular biology, 2000, Jul-07, Volume: 300, Issue:2 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arginine; Aspartic Acid; Aspartic Acid Endopeptidases; Binding Sites; Crystallography, X-Ray; Endopeptidases; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Sequence Alignment; Static Electricity; Substrate Specificity	2000
Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease. Lancet (London, England), 2000, May-13, Volume: 355, Issue:9216 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Prospective Studies; Sensitivity and Specificity	2000
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study. Neurology, 2000, Jul-25, Volume: 55, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorders; Creatine; Disease Progression; Energy Metabolism; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Occipital Lobe; Reference Values; Temporal Lobe	2000
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. The European journal of neuroscience, 2000, Volume: 12, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine	2000
Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD. Neurology, 2000, Sep-12, Volume: 55, Issue:5 Topics: Aged; Alzheimer Disease; Aspartic Acid; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe	2000
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:8-9 Topics: Aged; Alzheimer Disease; Aspartic Acid; Child; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Japan; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide	2000
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta neurologica Scandinavica. Supplementum, 2000, Volume: 176 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Cell Culture Techniques; Cell Membrane; DNA, Complementary; Endopeptidases; Gene Expression Regulation; Humans; Membrane Proteins; Mice; Point Mutation; Presenilin-1; Presenilin-2; Protein Conformation	2000
The Glu298Asp polymorphism in the NOS3 gene is not associated with sporadic Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 70, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Glutamic Acid; Humans; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic	2001
Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease. The International journal of neuroscience, 2001, Volume: 107, Issue:3-4 Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Female; Glucose; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Tomography, Emission-Computed	2001
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments. Neuroscience, 2001, Volume: 104, Issue:4 Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptides; Animals; Aspartic Acid; Chymotrypsin; Coloring Agents; Endopeptidases; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Acid; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; PC12 Cells; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Serine	2001
Effects of ENA713 and CHF2819, two anti-Alzheimer's disease drugs, on rat amino acid levels. Brain research, 2001, Aug-10, Volume: 910, Issue:1-2 Topics: Alzheimer Disease; Animals; Arginine; Aspartic Acid; Carbamates; Cholinesterase Inhibitors; Citrulline; Cyclic N-Oxides; Dose-Response Relationship, Drug; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurons; Phenylcarbamates; Rats; Rats, Wistar; Rivastigmine; Synaptic Transmission; Taurine	2001
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport, 2001, Aug-08, Volume: 12, Issue:11 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognition Disorders; Creatine; Diagnosis, Differential; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Protons	2001
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. Neurology, 2001, Aug-28, Volume: 57, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Dementia; Female; Humans; Hydrogen; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Regression Analysis	2001
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. The Journal of biological chemistry, 2001, Nov-16, Volume: 276, Issue:46 Topics: Alzheimer Disease; Animals; Aspartic Acid; Blotting, Western; Down-Regulation; Endoplasmic Reticulum; Fibroblasts; Genes, Dominant; Humans; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Fluorescence; Mutation; Plasmids; Presenilin-1; Protein Binding; Protein Folding; Signal Transduction; Stress, Physiological; Time Factors; Transduction, Genetic; Transfection; Tumor Cells, Cultured	2001
Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology, 2001, Sep-11, Volume: 57, Issue:5 Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Statistics, Nonparametric; Temporal Lobe	2001
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. Journal of molecular biology, 2001, Oct-05, Volume: 312, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloidosis; Asparagine; Aspartic Acid; Chromatography, Gel; Circular Dichroism; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary	2001
A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease. Neurology, 2001, Nov-27, Volume: 57, Issue:10 Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Aspartic Acid; Genetic Carrier Screening; Humans; Male; Membrane Proteins; Middle Aged; Mutation, Missense; Pedigree; Presenilin-2; Spain	2001
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases. International journal of geriatric psychiatry, 2001, Volume: 16, Issue:12 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Reference Values	2001
Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology, 2002, Mar-26, Volume: 58, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Atrophy; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parietal Lobe; Temporal Lobe	2002
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease. Neuroreport, 2002, Jan-21, Volume: 13, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Reference Values; Tissue Distribution	2002
Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Archives of neurology, 2002, Volume: 59, Issue:5 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Phosphocreatine	2002
N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study. Neurology, 1992, Volume: 42, Issue:8 Topics: Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; Cadaver; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male	1992
Quantification of D-aspartate in normal and Alzheimer brains. Neuroscience letters, 1992, Aug-31, Volume: 143, Issue:1-2 Topics: Alzheimer Disease; Amino Acid Oxidoreductases; Aspartate Aminotransferases; Aspartic Acid; Brain Chemistry; D-Aspartate Oxidase; Humans; Hydrolysis; Malate Dehydrogenase; Stereoisomerism; Substrate Specificity	1992
Altered aspartate in Alzheimer neurofibrillary tangles. Neurochemical research, 1992, Volume: 17, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Female; Humans; Male; Methylation; Middle Aged; Nerve Tissue Proteins; Neurofibrillary Tangles; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases	1992
Racemized D-aspartate in Alzheimer neurofibrillary tangles. Brain research bulletin, 1992, Volume: 28, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Benzothiazoles; Chromatography, Gas; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Neurofibrillary Tangles; Stereoisomerism; Thiazoles	1992
Free D-aspartate and D-alanine in normal and Alzheimer brain. Brain research bulletin, 1991, Volume: 26, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Humans; Isomerism; Middle Aged; Reference Values	1991
Distribution of neurofibrillary tangle formation and [3H]-D-aspartate receptor binding in the thalamus in the normal elderly brain, in Alzheimer's disease and in Parkinson's disease. Neuropathology and applied neurobiology, 1990, Volume: 16, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Humans; Male; Neurons; Parkinson Disease; Receptors, Amino Acid; Receptors, Cell Surface; Reference Values; Thalamus; Tritium	1990
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia. Journal of neurochemistry, 1990, Volume: 54, Issue:2 Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values	1990
Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:4 Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Aspartic Acid; Autoradiography; Cerebral Cortex; Female; Glutamates; Humans; Ibotenic Acid; Kainic Acid; Male; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Tritium	1990
Sodium dependent D-[3H]aspartate binding in cerebral cortex in patients with Alzheimer's and Parkinson's diseases. Neuroscience letters, 1987, Aug-18, Volume: 79, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Choline O-Acetyltransferase; Humans; In Vitro Techniques; Kinetics; Parkinson Disease; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium	1987
Regional changes in [3H]D-aspartate and [3H]TCP binding sites in Alzheimer's disease brains. Brain research, 1988, Oct-11, Volume: 462, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Female; Humans; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1988
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:5 Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents	1985
Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate. Journal of the neurological sciences, 1985, Volume: 68, Issue:2-3 Topics: Alzheimer Disease; Aspartic Acid; Culture Techniques; Cytoskeleton; Fetus; Glutamates; Glutamic Acid; Humans; Microscopy, Electron; Models, Neurological; Neurofibrils; Spinal Cord	1985
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type. Annals of neurology, 1986, Volume: 19, Issue:3 Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Nerve Tissue Proteins; Osmolar Concentration; Postmortem Changes; Tissue Distribution	1986
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease. Neuroscience research, 1986, Volume: 3, Issue:6 Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission	1986
A postmortem study of amino acid neurotransmitters in Alzheimer's disease. Annals of neurology, 1986, Volume: 20, Issue:5 Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Taurine	1986
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding. Journal of neurochemistry, 1987, Volume: 48, Issue:2 Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution	1987
Glutamate deficits in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Middle Aged	1987
Region-specific loss of glutamate innervation in Alzheimer's disease. Neuroscience letters, 1987, Jan-02, Volume: 73, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Hippocampus; Humans; Synaptosomes	1987
The dementia of Alzheimer's disease: an update. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:2 Topics: Afferent Pathways; Alzheimer Disease; Amygdala; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Substantia Innominata	1987
Glutamatergic denervation in Alzheimer's disease--a cautionary note. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:6 Topics: Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration	1987
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease. Neuroscience letters, 1988, Mar-21, Volume: 86, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe	1988
Topographical distribution of neurochemical changes in Alzheimer's disease. Journal of the neurological sciences, 1988, Volume: 84, Issue:2-3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cerebellar Cortex; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutaminase; Glutamine; Humans; Middle Aged; Somatostatin	1988
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease. Brain research, 1988, Jun-14, Volume: 452, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kinetics; Male; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1988
Anatomical organization of excitatory amino acid receptors and their properties. Advances in experimental medicine and biology, 1986, Volume: 203 Topics: Alzheimer Disease; Animals; Aspartic Acid; Autoradiography; Brain; Brain Mapping; Calcium; Glutamates; Humans; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship	1986
Neuritic plaque amyloid in Alzheimer's disease is highly racemized. Journal of neurochemistry, 1988, Volume: 50, Issue:1 Topics: Aged; Alzheimer Disease; Amino Acids; Amyloid; Amyloid beta-Peptides; Aspartic Acid; Brain Chemistry; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hydrolysis; Isomerism; Male; Middle Aged; Molecular Weight; Protein Precursors; Racemases and Epimerases; Serine	1988
Glutamate/aspartate-releasing neurons in Alzheimer's disease. The New England journal of medicine, 1986, Jun-26, Volume: 314, Issue:26 Topics: Alzheimer Disease; Aspartic Acid; Glutamates; Humans; In Vitro Techniques; Neurons; Temporal Lobe	1986
D-aspartate in human brain. Journal of neurochemistry, 1987, Volume: 48, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Child; Child, Preschool; Humans; Infant; Isomerism; Middle Aged; Tissue Distribution	1987