aspartic acid has been researched along with Acidosis, Lactic in 6 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 7.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| " Mutation carriers included 45 patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); 11 participants who would develop the MELAS syndrome during follow-up (converters); and 79 participants who would not develop the MELAS syndrome during follow-up (nonconverters)." | 3.80 | Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers. ( De Vivo, D; DiMauro, S; Engelstad, KM; Hinton, V; Kaufmann, P; Mao, X; Shungu, D; Weiduschat, N, 2014) |
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 3.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| " Within 5-15 min after the onset of reperfusion, the Lac/NAA peak ratio increased further in all rats; however, only in extremely hyperglycemic rats (serum glucose greater than 960 mg/dl) did the lactic acidosis progress rather than recover later during reperfusion." | 3.68 | Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. ( Abiko, H; Faden, AI; James, TL; Weinstein, PR; Widmer, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weiduschat, N | 1 |
| Kaufmann, P | 1 |
| Mao, X | 1 |
| Engelstad, KM | 1 |
| Hinton, V | 1 |
| DiMauro, S | 1 |
| De Vivo, D | 1 |
| Shungu, D | 1 |
| van Baalen, A | 1 |
| Stephani, U | 1 |
| Rohr, A | 1 |
| Cross, JH | 1 |
| Gadian, DG | 1 |
| Connelly, A | 1 |
| Leonard, JV | 1 |
| Sappey-Marinier, D | 1 |
| Chileuitt, L | 1 |
| Weiner, MW | 1 |
| Faden, AI | 2 |
| Weinstein, PR | 2 |
| Widmer, H | 1 |
| Abiko, H | 1 |
| James, TL | 1 |
| Jacquin, T | 1 |
| Fortin, G | 1 |
| Pasquier, C | 1 |
| Gillet, B | 1 |
| Béloeil, JC | 1 |
| Champagnat, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitochondrial Encephalomyopathies and Mental Retardation: Investigations of Clinical Syndromes Associated With MtDNA Point Mutations[NCT01532791] | 300 participants (Anticipated) | Observational | 2004-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for aspartic acid and Acidosis, Lactic
| Article | Year |
|---|---|
Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers.
Topics: Acidosis, Lactic; Adult; Aged; Aspartic Acid; Cerebral Cortex; Choline; Creatine; DNA, Mitochondrial | 2014 |
Increased brain lactate during stroke-like episode in a patient with congenital disorder of glycosylation type Ia.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Carbohydrate Metabolism, Inborn Errors; Child; Female; Fever | 2009 |
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Female; Humans; | 1993 |
Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Energy Metabolism; Hydrogen | 1995 |
Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Energy Metabolism; Fatty | 1992 |
Metabolic acidosis induced by N-methyl-D-aspartate in brain slices of the neonatal rat: 31P- and 1H-magnetic resonance spectroscopy.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Frontal Lobe; Glucose; Hydrogen; Hydrogen-Ion Concentratio | 1988 |