Page last updated: 2024-08-17

aspartic acid and Ache

aspartic acid has been researched along with Ache in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199010 (26.32)18.7374
1990's3 (7.89)18.2507
2000's17 (44.74)29.6817
2010's8 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrés, E; Fayed, N; Garcia-Campayo, J; Modrego, PJ; Viguera, L1
De Lange, FP; Geurts, DEM; Knoop, H; Roelofs, K; Schmits, IC; Toni, I; van der Meer, JWM; van der Schaaf, ME1
Clemente, FR; Somers, DL1
Geisslinger, G; Kettner, M; Lötsch, J; Oertel, BG; Renné, C; Roskam, B; Schmidt, PH; Scholich, K1
Hernández, L; Páez, X; Quiñones, B; Silva, E1
Radhakrishnan, R; Sluka, KA1
Erdtel, M; Gussew, A; Kaiser, WA; Mentzel, HJ; Reichenbach, JR; Rzanny, R; Scholle, HC1
Andres, E; Andrés-Bergareche, H; Beltrán, J; Fayed, N; Garcia-Campayo, J; Luciano, JV; Magallón, R1
Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X1
Binkert, CA; Brügger, M; Ettlin, DA; Froehlich, JM; Graf, N; Gutzeit, A; Meier, D; Meier, ML; von Weymarn, C1
Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M1
Constandil, L; Hernández, A; Laurido, C; Pelissier, T1
Bai, ZT; Chen, B; Ji, YH; Shen, J; Zhang, JW; Zhang, XY1
Apkarian, AV; Fredrickson, BE; Grachev, ID1
Chang, YC; Cherng, CH; Tao, PL; Wang, JJ; Wen, ZH; Wong, CS1
Dmitrieva, N; Hernández, L; Pérez, J; Rodríguez-Malaver, AJ1
Binns, BC; Chu, Y; Johns, RA; Liaw, WJ; Rothstein, JD; Sepkuty, JP; Stephens, RL; Tao, YX1
Fujita, T; Jin, YH; Nishioka, H; Wakabayashi, K; Yonehara, N1
Hernández, L; Silva, E1
Siddall, PJ; Sorensen, L; Trenell, MI; Yue, DK1
Malmberg, AB; Yaksh, TL1
Ekblom, A; Ekman-Ordeberg, G; Irestedt, L; Nyberg, F; Olofsson, C; Ungerstedt, U; Wiklund, P1
Cheng, JK; Lin, CR; Marsala, M; Tsai, PS; Wen, GH; Yang, LC1
Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K1
Apkarian, AV; Fredickson, BE; Grachev, ID1
Freund, N; Gonzalez, LE; Hernandez, L; Quiñones, B; Silva, E1
Grachev, ID; Ramachandran, TS; Thomas, PS1
Hodkewitsch, E; Saurugg, D1
Argyropoulos, G; Clarici, G; Heppner, F1
Gebhart, GF; Sherman, AD1
Larson, AA; Skilling, SR; Smullin, DH1
DeLander, GE; Wahl, JJ1
Aanonsen, LM; Wilcox, GL1
Jacquet, YF1
Elekes, I; Láng, T; Palkovits, M; Patthy, A1
Raigorodsky, G; Urca, G1
Caudle, RM; Isaac, L1
Krüger, K1

Trials

3 trial(s) available for aspartic acid and Ache

ArticleYear
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:1

    Topics: Adult; Analgesia; Aspartic Acid; Brain; Chronic Disease; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Pain Management; Pancreatitis, Chronic; Radionuclide Imaging; Severity of Illness Index; Somatosensory Cortex; Transcranial Magnetic Stimulation; Treatment Outcome

2011
Brain chemistry reflects dual states of pain and anxiety in chronic low back pain.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:10

    Topics: Adult; Anxiety; Aspartic Acid; Biomarkers; Brain Chemistry; Female; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Low Back Pain; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Pain Measurement; Thalamus

2002
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
    Wiener medizinische Wochenschrift (1946), 1977, Aug-15, Volume: 127, Issue:15

    Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; Migraine Disorders; Nervous System Diseases; Pain; Pyridoxine; Reflex Sympathetic Dystrophy; Solutions

1977

Other Studies

35 other study(ies) available for aspartic acid and Ache

ArticleYear
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
    Academic radiology, 2014, Volume: 21, Issue:9

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Prospective Studies

2014
Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.
    Biological psychiatry, 2017, 02-15, Volume: 81, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Creatine; Fatigue Syndrome, Chronic; Female; Glutamates; Gray Matter; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Pain; Prefrontal Cortex; Severity of Illness Index; Young Adult

2017
Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats.
    The journal of pain, 2009, Volume: 10, Issue:2

    Topics: Acupuncture Points; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurotransmitter Agents; Pain; Pain Management; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Transcutaneous Electric Nerve Stimulation

2009
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
    The Journal of biological chemistry, 2009, Mar-06, Volume: 284, Issue:10

    Topics: Alleles; Amino Acid Substitution; Analgesics, Opioid; Asparagine; Aspartic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation; Homozygote; Humans; Pain; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Receptors, Opioid, mu; Somatosensory Cortex; Thalamus

2009
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
    Investigacion clinica, 2008, Volume: 49, Issue:4

    Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; Disinfectants; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Pain; Rats; Rats, Wistar

2008
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
    Neuroscience letters, 2009, Jul-03, Volume: 457, Issue:3

    Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutamic Acid; Glycine; Male; Medulla Oblongata; Microdialysis; Muscle, Skeletal; Pain; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Chloride

2009
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
    NeuroImage, 2010, Jan-15, Volume: 49, Issue:2

    Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperature; Humans; Magnetic Resonance Spectroscopy; Male; Pain; Periodicity; Physical Stimulation; Protons; Time Factors

2010
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
    Arthritis research & therapy, 2010, Volume: 12, Issue:4

    Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; Fibromyalgia; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Male; Middle Aged; Motor Cortex; Nuclear Magnetic Resonance, Biomolecular; Pain; Protons; Somatosensory Cortex

2010
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
    European radiology, 2011, Volume: 21, Issue:4

    Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Anatomic; Neurotransmitter Agents; Pain; Prospective Studies; Protons; Tooth Diseases; Trigeminal Nerve

2011
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Inflammation; Kainic Acid; Male; Nicotinic Acids; Pain; Phosphoserine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord

2011
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Epimerases; Rats; Serine

2012
Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch.
    Brain research bulletin, 2002, Volume: 58, Issue:1

    Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurotransmitter Agents; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Scorpion Venoms

2002
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
    Brain research, 2004, Jan-09, Volume: 995, Issue:2

    Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors

2004
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Aminobutyric Acid; Glutamic Acid; Inflammation; Male; Microdialysis; Neurotransmitter Agents; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Wistar; Reaction Time; Synaptic Transmission; Up-Regulation

2004
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.
    Pain, 2005, Volume: 115, Issue:1-2

    Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission

2005
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
    Neuroscience, 2006, Volume: 138, Issue:4

    Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction

2006
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
    Investigacion clinica, 2007, Volume: 48, Issue:2

    Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar

2007
Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy.
    Diabetes care, 2008, Volume: 31, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diabetic Neuropathies; Female; Frontal Lobe; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Reference Values; Sensory Thresholds; Thalamus

2008
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4

    Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid; Hindlimb; Ibuprofen; Injections, Spinal; Male; Microdialysis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors

1995
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
    Neuroreport, 1997, Mar-03, Volume: 8, Issue:4

    Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Metalloendopeptidases; Middle Aged; Nitric Oxide; Pain; Postmenopause; Pregnancy; Reference Values; Substance P

1997
Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats.
    Neuroscience letters, 2001, Mar-30, Volume: 301, Issue:2

    Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Magnesium Sulfate; Male; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Taurine

2001
Characterization of the glutamatergic system for induction and maintenance of allodynia.
    Brain research, 2001, Mar-23, Volume: 895, Issue:1-2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch

2001
Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain.
    Molecular psychiatry, 2001, Volume: 6, Issue:3

    Topics: Anxiety; Aspartic Acid; Brain Chemistry; Brain Mapping; Chronic Disease; Humans; Neurons; Pain

2001
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
    Brain research, 2001, Dec-27, Volume: 923, Issue:1-2

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glutamic Acid; Male; Microdialysis; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Synaptic Transmission; Ventral Thalamic Nuclei

2001
Decreased levels of N-acetylaspartate in dorsolateral prefrontal cortex in a case of intractable severe sympathetically mediated chronic pain (complex regional pain syndrome, type I).
    Brain and cognition, 2002, Volume: 49, Issue:1

    Topics: Adult; Anxiety Disorders; Aspartic Acid; Chronic Disease; Depressive Disorder, Major; Female; Humans; Magnetic Resonance Imaging; Pain; Pain Measurement; Prefrontal Cortex

2002
[Infusion therapy of pain in a series of neurological-neurosurgical patients].
    Wiener medizinische Wochenschrift (1946), 1976, Jun-11, Volume: 126, Issue:24

    Topics: Analgesics; Aspartic Acid; Dipyrone; Drug Combinations; Female; Humans; Magnesium; Male; Orphenadrine; Pain; Postoperative Complications; Potassium

1976
Morphine and pain: effects on aspartate, GABA and glutamate in four discrete areas of mouse brain.
    Brain research, 1976, Jul-09, Volume: 110, Issue:2

    Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Hypothalamus; Male; Mice; Morphine; Naloxone; Pain; Reticular Formation; Stress, Physiological

1976
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
    Pain, 1990, Volume: 42, Issue:1

    Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine

1990
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2

    Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P

1988
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Narcotics; Nociceptors; Oxadiazoles; Pain; Phencyclidine; Phentolamine; Quisqualic Acid; Receptors, Opioid; Receptors, sigma; Spinal Cord

1987
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter

1988
Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.
    Brain research, 1986, May-14, Volume: 373, Issue:1-2

    Topics: Animals; Aspartic Acid; Brain Chemistry; Dextroamphetamine; Glutamates; Glutamic Acid; Male; Pain; Rats; Stress, Physiological

1986
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
    Brain research, 1987, Sep-29, Volume: 422, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain; Rats; Valine

1987
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
    Brain research, 1988, Mar-08, Volume: 443, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dipeptides; Dynorphins; Hot Temperature; Kinetics; Male; N-Methylaspartate; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine

1988
[Metabolic therapeutic possibilities of ischemic heart disease].
    Medizinische Klinik, 1967, Oct-20, Volume: 62, Issue:42

    Topics: Angina Pectoris; Aspartic Acid; Coronary Disease; Electrocardiography; Female; Humans; Hypertension; Magnesium; Male; Middle Aged; Myocardium; Nitroglycerin; Pain; Potassium; Prenylamine

1967