Page last updated: 2024-08-17

aspartic acid and ALS - Amyotrophic Lateral Sclerosis

aspartic acid has been researched along with ALS - Amyotrophic Lateral Sclerosis in 105 studies

Research

Studies (105)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.95)	18.7374
1990's	30 (28.57)	18.2507
2000's	37 (35.24)	29.6817
2010's	33 (31.43)	24.3611
2020's	4 (3.81)	2.80

Authors

Authors	Studies
Batlle, C; Carrera-García, L; Codina, A; Expósito-Escudero, J; Garcia-Cabau, C; Hoenicka, J; Jou, C; Nascimento, A; Natera-de Benito, D; Olival, J; Ortez, C; Palau, F; Roldan, M; Salvatella, X	1
Blicher, JU; Eskildsen, SF; Figlewski, K; Møller, AT; Near, J; Stærmose, TG	1
Barberis, M; Brunetti, M; Calvo, A; Cammarosano, S; Canosa, A; Chiò, A; De Marco, G; Grassano, M; Manera, U; Moglia, C; Vasta, R	1
Abe, T; Haji, S; Harada, M; Izumi, Y; Kaji, R; Matsumoto, Y; Murakami, N; Osaki, Y; Sako, W	1
Briemberg, H; Eurich, DT; Frayne, R; Genge, AL; Graham, SJ; Hanstock, C; Ishaque, A; Kalra, S; Korngut, L; Luk, C; Seres, P; Srivastava, O; Ta, D; Zinman, L	1
Atassi, N; Cernasov, P; Keil, B; Lawson, R; Long, CJ; Murphy, A; Paganoni, S; Ratai, EM; Ratti, E; Rosen, B; Salibi, N; Seethamraju, R; Triantafyllou, C; Xu, M	1
Bagnoli, S; Berti, V; Bessi, V; Braccia, A; Del Mastio, M; Matà, S; Nacmias, B; Piaceri, I; Pignone, AM; Polito, C; Pupi, A; Sorbi, S; Tedde, A	1
Cheong, I; Deelchand, DK; Eberly, LE; Guliani, G; Manousakis, G; Marjańska, M; Öz, G; Walk, D	1
Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT	1
D'Angelo, S; Daniele, L; Galletti, P; Monsurrò, MR; Raimo, M; Salvatore, A; Trojsi, F	1
Abdolvahabi, A; Cook, NP; Kohn, T; Marti, AA; Rhodes, NR; Shaw, BF; Shi, Y	1
Brunetti, A; Cervo, A; Cocozza, S; Giorgio, SMDA; Marsili, A; Morra, VB; Palma, V; Quarantelli, M; Saccà, F; Tedeschi, E; Vacca, G	1
Barthelme, D; Jauregui, R; Sauer, RT	1
Abe, T; Harada, M; Izumi, Y; Kaji, R; Sako, W	1
Blanquer, M; García Santos, JM; Gómez Espuch, J; Iniesta, F; Inuggi, A; María Moraleda, J; Martínez, S; Vázquez, C	1
Corsini, S; Nistri, A; Tortora, M	1
Chen, W; Li, X; Lin, H; Luo, J; Sun, G; Wang, Y; Wang, Z; Xu, Y	1
Mali, Y; Zisapels, N	1
Beaulieu, C; Concha, L; Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Wong, JC	1
Ishige, K; Ito, Y; Kosuge, Y; Negi, H; Sekikawa-Nishida, K	1
Fiszman, ML; Latini, A; Ricart, KC; Rodríguez, G; Sica, RE	1
Choi, JK; Dedeoglu, A; Jenkins, BG; Küstermann, E	1
Govind, V; Maudsley, AA; Schuff, N; Sharma, K; Studholme, C; Young, K	1
Bianchi, F; Bongioanni, P; Canapicchi, R; Frijia, F; Hlavata, H; Lombardo, F; Minichilli, F; Montanaro, D; Rossi, B	1
Mali, Y; Zisapel, N	1
Bittšanský, M; Dobrota, D; Grofik, M; Kurča, E; Nosál', V; Poláček, H; Sivák, S; Turčanová-Koprušáková, M	1
Grieb, P; Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A	1
Bernabei, C; Bragato, C; Chiari, A; Gellera, C; Georgoulopoulou, E; Mandrioli, J; Sola, P	1
Caraballo-Miralles, V; Lladó, J; Olmos, G; Tolosa, L	1
Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Sudharshan, N	1
Cifra, A; Nani, F; Nistri, A	1
Camicioli, R; Choi, C; Johnston, W; Kalra, S; Lynch, M; Sekhon, R; Seres, P; Usman, U	1
Bisogni, G; Conte, A; Del Grande, A; Lattante, S; Luigetti, M; Madia, F; Marangi, G; Sabatelli, M; Zollino, M	1
Andersen, PM; Benatar, M; Carew, JD; Gronka, S; Hu, X; Nair, G; Wuu, J	1
Capozzo, R; Ceci, E; D'Errico, E; Leo, A; Livrea, P; Logroscino, G; Mastrapasqua, M; Ruggieri, M; Simone, IL; Tortelli, R; Zoccolella, S	1
Bonanno, G; Bonifacino, T; Caponnetto, C; Carminati, E; Giribaldi, F; Giunti, D; Milanese, M; Morando, S; Principato, MC; Uccelli, A; Vergani, L; Voci, A	1
Callaghan, BC; Chenevert, TL; Edden, RA; Feldman, EL; Foerster, BR; Petrou, M	1
Arheart, KL; Govind, V; Maudsley, AA; Saigal, G; Sharma, KR; Sheriff, S	1
Anna Rossi, PI; Bonanno, G; Bonifacino, T; Di Prisco, S; Giribaldi, F; Milanese, M; Pittaluga, A; Puliti, A; Tacchetti, C; Usai, C	1
Jenkinson, M; Knight, S; Maudsley, AA; Stagg, CJ; Talbot, K; Turner, MR	1
Chawla, S; Elman, LB; Grossman, M; Maudsley, AA; McCluskey, LF; Melhem, ER; Poptani, H; Sheriff, S; Verma, G; Wang, S; Woo, JH	1
Arnold, DL; Caramanos, Z; Cashman, NR; Genge, A; Kalra, S	1
Del Corona, A; Filosto, M; Mancuso, M; Murri, L; Naini, A; Rocchi, A; Sartucci, F; Siciliano, G	1
Arnold, DL; Genge, A; Kalra, S	1
Shigeri, Y; Shimamoto, K	1
Askmark, H; Persson, LI; Ryberg, H	1
Fukada, K; Hirata, S; Nagano, S; Nakanishi, T; Okuno, T; Sakoda, S; Sato, T; Shimizu, A; Sugai, F; Yamamoto, Y; Zhou, Z	1
Cai, Y; Gao, Y; Guo, X; Li, D; Liang, Y; Lim, CC; Ma, L; Yin, H	1
Arnold, DL; Kalra, S	1
Gelinas, DF; Miller, RG; Rule, RR; Schuff, N; Suhy, J; Weiner, MW	1
Banci, L; Bertini, I; D'Amelio, N; Gaggelli, E; Libralesso, E; Matecko, I; Turano, P; Valentine, JS	1
Hemptinne, I; Hermans, E; Maloteaux, JM; Tilleux, S; Vanhoutte, N; Vermeiren, C	1
Desiderio, LM; Elman, LB; Krejza, J; McCluskey, LF; Melhem, ER; Poptani, H; Wang, S; Woo, JH	1
Conforti, FL; Gabriele, A; Labella, V; Magariello, A; Majorana, G; Mazzei, R; Monsurrò, MR; Muglia, M; Patitucci, A; Quattrone, A; Simone, IL; Sprovieri, T; Tedeschi, G; Tessitore, A; Ungaro, C; Valentino, P	1
Chao, L; Laxer, K; Meyerhoff, DJ; Mueller, S; Sacrey, DT; Schuff, N; Weiner, MW	1
Arnold, DL; Cashman, NR; Genge, A; Kalra, S; Vitale, A	1
Gordon, P; Lu, J; Mehrazin, M; Mitsumoto, H; Naini, A	1
Chen, L; Huang, H; Liu, Y; Tan, K; Wang, H; Xi, H; Xue, Y; Zhang, F; Zhang, J	1
Kassubek, J; Ludolph, AC; Unrath, A	1
Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W	1
Battista, V; Chan, S; Dashnaw, S; Floyd, AG; Gooch, CL; Gordon, PH; Hayes, S; Hays, AP; Hirsch, J; Kaufmann, P; Levin, B; Mao, X; Mitsumoto, H; Montes, J; Pullman, SL; Rowland, LP; Shungu, DC; Tang, MX; Ulug, AM	1
Coutinho, CM; Gatt, JA; Gunawardena, WJ; Jones, AP; Mitchell, JD; Shaw, IC	1
Gredal, O; Møller, SE	1
Chinnery, RM; Ince, PG; Shaw, PJ	1
Fujita, K; Honda, M; Nagata, Y	1
Blin, O; Nieoullon, A; Samuel, D; Serratice, G	1
Dykes-Hoberg, M; Jin, L; Kuncl, RW; Rothstein, JD	1
Constantakakis, E; Plaitakis, A	1
Baudouin, N; Bernard, D; Brunotte, F; Dumas, R; Giroud, M; Lemesle, M; Martin, D; Walker, P	1
Jones, AP; Knight, JM; Redmond, JP; Shaw, IC	1
Gredal, O; Karlsborg, M; Rosenbaum, S; Strange, P; Topp, S; Werdelin, L	1
Appel, SH; Goodman, JC; La Bella, V	1
Andersen, PM; Forsgren, L; Marklund, SL; Nilsson, P	1
Fujii, H; Ichijo, M; Ikeda, K; Irimajiri, S; Iwasaki, Y; Kinoshita, M; Matsuoka, Y	1
Gelinas, D; Maudsley, AA; Miller, RG; Rooney, WD; Schuff, N; Weiner, MW	1
Arnold, DL; Cashman, NR; Genge, A; Kalra, S	1
Eum, WS; Kang, JH; Kim, SM	1
Andrews, C; Dawson, JM; Ellis, CM; Leigh, PN; Simmons, A; Williams, SC	1
Klinkosz, B; Mitsumoto, H; Moore, JK; Ng, TC; Pioro, EP; Trapp, BD; Wang, Y	1
Eum, WS; Kang, JH; Kim, SM; Kwon, OB	1
Majors, AW; Mitsumoto, H; Nelson, DR; Ng, TC; Pioro, EP	1
Janik, P; Niebroj-Dobosz, I	1
Arnold, DL; Cashman, NR; Kalra, S	1
Chan, S; Douglas-Akinwande, A; Lange, DJ; Rowland, LP; Shungu, DC	1
Bowen, BC; Bradley, WG; Pattany, PM; Rotta, F	1
Alexander, GM; Deitch, JS; Del Valle, L; Heiman-Patterson, TD; Seeburger, JL	1
Aĭrapetian, KV; Barkhatova, VP; Nikitin, SS; Zavalishin, IA	1
Kondratyeva, EA; Levitsky, GN; Limborska, SA; Shadrina, MI; Skvortsova, VI; Slominsky, PA; Tupitsina, TV	1
Block, W; Grothe, C; Karitzky, J; Klockgether, T; Lamerichs, R; Pohl, C; Schild, H; Schmidt, S; Träber, F	1
Hahn, D; Kenn, W; Ochs, G; Pabst, TA	1
Abe, K; Fujita, N; Hirabuki, N; Takanashi, M; Tanaka, H; Watanabe, Y; Yanagihara, T	1
Block, W; Grothe, C; Klockgether, T; Pels, H; Pohl, C; Schild, HH; Schmidt, S; Träber, F	1
Elger, CE; Feistner, H; Heinze, HJ; Kanowski, M; Kaufmann, J; Kunz, WS; Sailer, M; Tempelmann, C; Vielhaber, S	1
Bak, MI; Domzał-Stryga, A; Królicki, L; Kwieciński, H	1
Dronsky, V; Gelinas, D; Licht, J; Maudsley, AA; Miller, RG; Rule, R; Schuff, N; Suhy, J; Weiner, MW	1
Cwik, VA; Hanstock, CC; Martin, WR	1
Emeryk-Szajewska, B; Karwańska, A; Kostera-Pruszczyk, A; Niebroj-Dobosz, I; Rowińska-Marcińska, K	1
Janik, P; Kwieciński, H; Niebroj-Dobosz, I	1
Ono, S; Yamauchi, M	1
Blin, O; Guieu, R; Nieoullon, A; Pouget, J; Samuel, D; Serratrice, G	1
Chaudhry, V; Clawson, L; Cornblath, DR; Coyle, JT; Drachman, DB; Kuncl, R; Rothstein, JD	1
Coyle, JT; Hedreen, JC; Kuncl, R; Rothstein, JD; Sim, L; Stauch-Slusher, B; Tsai, GC	1
Martin, DL; Spink, DC	1
Clawson, L; Cornblath, DR; Coyle, JT; Drachman, DB; Kuncl, RW; Pestronk, A; Rothstein, JD; Stauch, BL; Tsai, G	1
Constantakakis, E; Plaitakis, A; Smith, J	1

Reviews

5 review(s) available for aspartic acid and ALS - Amyotrophic Lateral Sclerosis

Article	Year
[Excitatory amino acid transporters: development of regulatory molecules for their functional analysis]. Seikagaku. The Journal of Japanese Biochemical Society, 2003, Volume: 75, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate	2003
ALS surrogate markers. MRS. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004, Volume: 5 Suppl 1 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Motor Cortex	2004
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Cocaine; Creatine; Epilepsy; Ethanol; HIV Infections; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseases; Neurons; Stress Disorders, Post-Traumatic	2006
Biological markers in the diagnosis and treatment of ALS. Journal of the neurological sciences, 1999, Volume: 165 Suppl 1 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Progression; Electromyography; Humans; Magnetic Resonance Imaging; Monitoring, Physiologic; Neuroprotective Agents; Riluzole; Tomography, Emission-Computed	1999
[Proton MR spectroscopy studies of the brain in ALS patients]. Neurologia i neurochirurgia polska, 2001, Volume: 35, Issue:1 Suppl Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Disease Progression; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Motor Cortex; Protons; Severity of Illness Index	2001

Trials

9 trial(s) available for aspartic acid and ALS - Amyotrophic Lateral Sclerosis

Article	Year
The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis. European journal of radiology, 2015, Volume: 84, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multimodal Imaging; Pyramidal Tracts; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity	2015
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis. Archives italiennes de biologie, 2009, Volume: 147, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Disease Progression; Female; Humans; Male; Middle Aged; Phosphocreatine; Pyramidal Tracts; Reproducibility of Results; Sensitivity and Specificity	2009
Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar Degeneration; Gliosis; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Prefrontal Cortex; Protons	2011
A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain Chemistry; Brain-Derived Neurotrophic Factor; Feasibility Studies; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons; Placebos; Prospective Studies; Sensitivity and Specificity; Treatment Outcome	2003
A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters. Acta neurologica Scandinavica, 2003, Volume: 108, Issue:1 Topics: Adult; Aged; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Outcome Assessment, Health Care; Triazines	2003
Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis). Journal of the neurological sciences, 1995, Volume: 129 Suppl Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged	1995
Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport, 1998, Jun-01, Volume: 9, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Excitatory Amino Acid Antagonists; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Motor Neurons; Riluzole	1998
Motor unit hyperexcitability in amyotrophic lateral sclerosis vs amino acids acting as neurotransmitters. Acta neurologica Scandinavica, 2002, Volume: 106, Issue:1 Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons; Muscle, Skeletal; Neurotransmitter Agents; Reference Values	2002
Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis. Acta neurologica Scandinavica, 2002, Volume: 106, Issue:1 Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Reference Values; Riluzole; Time	2002

Other Studies

91 other study(ies) available for aspartic acid and ALS - Amyotrophic Lateral Sclerosis

Article	Year
Common pathophysiology for ANXA11 disorders caused by aspartate 40 variants. Annals of clinical and translational neurology, 2023, Volume: 10, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Humans; Motor Neurons; Muscular Diseases; Mutation	2023
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T. Scientific reports, 2019, 11-26, Volume: 9, Issue:1 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gray Matter; Hand Strength; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Occipital Lobe; Pilot Projects; Severity of Illness Index; Single-Blind Method	2019
A familial amyotrophic lateral sclerosis pedigree discordant for a novel p.Glu46Asp heterozygous OPTN variant and the p.Ala5Val heterozygous SOD1 missense mutation. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2020, Volume: 75 Topics: Alanine; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Cycle Proteins; Female; Genetic Testing; Genetic Variation; Glutamine; Heterozygote; High-Throughput Nucleotide Sequencing; Humans; Male; Membrane Transport Proteins; Middle Aged; Mutation, Missense; Pedigree; Superoxide Dismutase-1; Valine	2020
MR spectroscopy and imaging-derived measurements in the supplementary motor area for biomarkers of amyotrophic lateral sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021, Volume: 42, Issue:10 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motor Cortex	2021
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study. Neurology, 2021, 08-24, Volume: 97, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Prefrontal Cortex; Severity of Illness Index	2021
Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis. PloS one, 2017, Volume: 12, Issue:5 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons	2017
Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline. Journal of Alzheimer's disease : JAD, 2018, Volume: 61, Issue:1 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; C9orf72 Protein; Cognitive Dysfunction; DNA Mutational Analysis; Female; Fluorodeoxyglucose F18; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Italy; Male; Mental Status and Dementia Tests; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Protein Serine-Threonine Kinases; Tyrosine	2018
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry, 2019, Volume: 90, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Motor Cortex; Motor Neurons; Pons; Prognosis; Proton Magnetic Resonance Spectroscopy; Upper Extremity	2019
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS. Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors	2013
Accumulation of altered aspartyl residues in erythrocyte membrane proteins from patients with sporadic amyotrophic lateral sclerosis. Neurochemistry international, 2013, Volume: 63, Issue:6 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Erythrocyte Membrane; Female; Humans; Male; Membrane Proteins; Methionine; Methionine Adenosyltransferase; Middle Aged; Oxidation-Reduction; Oxidative Stress; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Reactive Oxygen Species; S-Adenosylhomocysteine	2013
Deamidation of asparagine to aspartate destabilizes Cu, Zn superoxide dismutase, accelerates fibrillization, and mirrors ALS-linked mutations. Journal of the American Chemical Society, 2013, Oct-23, Volume: 135, Issue:42 Topics: Amyotrophic Lateral Sclerosis; Asparagine; Aspartic Acid; Humans; Models, Molecular; Molecular Structure; Mutation, Missense; Protein Stability; Superoxide Dismutase; Superoxide Dismutase-1; Temperature	2013
An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication. Protein science : a publication of the Protein Society, 2015, Volume: 24, Issue:9 Topics: Adenosine Triphosphatases; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Cycle Proteins; Humans; Hydrolysis; Models, Molecular; Proteasome Endopeptidase Complex; Protein Binding; Protein Transport; Protein Unfolding; Proteolysis; Valosin Containing Protein	2015
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 27 Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neurons	2016
Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: Magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus. Cytotherapy, 2016, Volume: 18, Issue:6 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell- and Tissue-Based Therapy; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neurons; Pilot Projects; Spinal Cord; Stem Cell Transplantation; Stem Cells	2016
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons. The Journal of physiology, 2016, 11-15, Volume: 594, Issue:22 Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Brain Stem; Endoplasmic Reticulum Stress; Glucosyltransferases; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neurodegenerative Diseases; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic	2016
Detecting neuronal dysfunction of hand motor cortex in ALS: A MRSI study. Somatosensory & motor research, 2017, Volume: 34, Issue:1 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Creatine; Female; Functional Laterality; Hand; Humans; Image Processing, Computer-Assisted; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Statistics, Nonparametric	2017
Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase. Neurobiology of disease, 2008, Volume: 32, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Line; Cytosol; Humans; Malate Dehydrogenase; Malates; Mice; Mice, Inbred C57BL; Neurons; Superoxide Dismutase	2008
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease Progression; Female; Humans; Internal Capsule; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Pyramidal Tracts; ROC Curve; Sensitivity and Specificity	2010
Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice. Neuroscience letters, 2009, Apr-24, Volume: 454, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 12; Cell Death; Cell Survival; Disease Models, Animal; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Organ Culture Techniques; Spinal Cord; Superoxide Dismutase	2009
In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses. Acta neurologica Scandinavica, 2010, Volume: 121, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Cerebrospinal Fluid; Female; Glutamic Acid; Humans; Male; Mice; Middle Aged; Neurons; Time Factors	2010
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. The European journal of neuroscience, 2009, Volume: 30, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, Animal; Glutamic Acid; Glutamine; In Vitro Techniques; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Protons; Spectrum Analysis; Superoxide Dismutase	2009
Multivariate statistical mapping of spectroscopic imaging data. Magnetic resonance in medicine, 2010, Volume: 63, Issue:1 Topics: Adult; Algorithms; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Choline; Creatinine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Reproducibility of Results; Sensitivity and Specificity	2010
VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition. Neurobiology of disease, 2010, Volume: 37, Issue:3 Topics: Aminooxyacetic Acid; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Carbon Dioxide; Cell Line, Transformed; Enzyme Inhibitors; Green Fluorescent Proteins; Hybridomas; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Malates; Metabolic Networks and Pathways; Mice; Recombinant Fusion Proteins; Superoxide Dismutase; Up-Regulation; Vascular Endothelial Growth Factor A	2010
Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis. Neuroradiology, 2010, Volume: 52, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatinine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reproducibility of Results; Sensitivity and Specificity	2010
Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study. Folia neuropathologica, 2010, Volume: 48, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Membrane; Cytoplasm; Endoplasmic Reticulum; Erythropoietin; Nerve Degeneration; Neurons; Neuropil; Neuroprotective Agents; Organ Culture Techniques; Rats; Spinal Cord; Vacuoles	2010
A novel SOD1 mutation in a young amyotrophic lateral sclerosis patient with a very slowly progressive clinical course. Muscle & nerve, 2010, Volume: 42, Issue:4 Topics: Adult; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Disease Progression; Electromyography; Humans; Leg; Male; Muscle Weakness; Muscle, Skeletal; Mutation; Peripheral Nerves; Phenotype; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Tyrosine	2010
TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB. Molecular and cellular neurosciences, 2011, Volume: 46, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Death; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Inflammation; Motor Neurons; NF-kappa B; Organ Culture Techniques; Oxidative Stress; Rats; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha	2011
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Neural Pathways; Thalamus	2011
Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block. The European journal of neuroscience, 2011, Volume: 33, Issue:5 Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Astrocytes; Bicuculline; Biomarkers; Convulsants; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Riluzole; Strychnine	2011
D11Y SOD1 mutation and benign ALS: a consistent genotype-phenotype correlation. Journal of the neurological sciences, 2011, Oct-15, Volume: 309, Issue:1-2 Topics: Aged; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Genetic Association Studies; Humans; Middle Aged; Mutation; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine	2011
Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS. Neurology, 2011, Oct-04, Volume: 77, Issue:14 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Family Health; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mutation; Risk Factors; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tritium	2011
Serum N-acetylaspartate level in amyotrophic lateral sclerosis. Archives of neurology, 2011, Volume: 68, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Chromatography, Liquid; Female; Humans; Italy; Logistic Models; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Middle Aged; Protons	2011
Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. Molecular medicine (Cambridge, Mass.), 2012, Jul-18, Volume: 18 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Movement; Central Nervous System; Disease Progression; Female; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Motor Activity; Oxidative Stress; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1	2012
Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis. Neurology, 2012, May-15, Volume: 78, Issue:20 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Protons; Radionuclide Imaging; Young Adult	2012
Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. PloS one, 2012, Volume: 7, Issue:4 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Choline; Creatine; Humans; Hydrogen; Magnetic Resonance Imaging; Male; Middle Aged; Pyramidal Tracts; Severity of Illness Index	2012
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis. Neuropharmacology, 2013, Volume: 66 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glutamic Acid; Glycine; Humans; Inositol Phosphates; Lumbar Vertebrae; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes	2013
Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. Neurology, 2013, Feb-12, Volume: 80, Issue:7 Topics: Aged; Amyotrophic Lateral Sclerosis; Anisotropy; Aspartic Acid; Brain; Case-Control Studies; Creatine; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Disabled Persons; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged	2013
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging. Radiology, 2013, Volume: 267, Issue:3 Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Echo-Planar Imaging; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Retrospective Studies	2013
Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:3 Topics: Acetates; Aged; Amines; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Survival; Creatine; Cyclohexanecarboxylic Acids; Energy Metabolism; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Parietal Lobe; Reference Values; Treatment Outcome	2003
A screening for superoxide dismutase-1 D90A mutation in Italian patients with sporadic amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2002, Volume: 3, Issue:4 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; DNA Primers; Female; Genetic Testing; Humans; Italy; Male; Middle Aged; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Superoxide Dismutase; Superoxide Dismutase-1	2002
Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses. Journal of the neurological sciences, 2004, Mar-15, Volume: 218, Issue:1-2 Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, Liquid; DNA Mutational Analysis; Erythrocytes; Exons; Family Health; Female; Glutamic Acid; Glycine; Histidine; Humans; Male; Molecular Biology; Molecular Sequence Data; Mutation; Precipitin Tests; Spectrometry, Mass, Electrospray Ionization; Superoxide Dismutase	2004
Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis. Journal of neurology, 2004, Volume: 251, Issue:10 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Mapping; Case-Control Studies; Creatine; Diffusion Magnetic Resonance Imaging; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pyramidal Tracts; Spinocerebellar Degenerations	2004
Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004, Volume: 5, Issue:3 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Cross-Sectional Studies; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Reference Values; Tritium	2004
Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution. The Journal of biological chemistry, 2005, Oct-28, Volume: 280, Issue:43 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Binding Sites; Circular Dichroism; Copper; Crystallization; Crystallography, X-Ray; Cysteine; Disulfides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Bonding; Ions; Magnetic Resonance Spectroscopy; Models, Molecular; Movement; Mutagenesis; Mutation; Polymerase Chain Reaction; Proteins; Spectrophotometry; Superoxide Dismutase; Zinc	2005
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. Journal of neurochemistry, 2006, Volume: 96, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Aspartic Acid; Astrocytes; Blotting, Northern; Calcium; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Immunohistochemistry; Male; Methoxyhydroxyphenylglycol; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Superoxide Dismutase; Tritium	2006
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T. Radiology, 2006, Volume: 239, Issue:3 Topics: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Forecasting; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Internal Capsule; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neuron Disease; Phosphocreatine; Prospective Studies; Pyramidal Tracts	2006
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy. Journal of negative results in biomedicine, 2006, May-29, Volume: 5 Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Case-Control Studies; Exons; Female; Gene Frequency; Genetic Variation; Glutamic Acid; Humans; Introns; Italy; Male; Middle Aged; Mutation; Vesicular Transport Proteins	2006
Cerebral degeneration predicts survival in amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry, 2006, Volume: 77, Issue:11 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival	2006
Identification of a novel D109Y mutation in Cu/Zn superoxide dismutase (sod1) gene associated with amyotrophic lateral sclerosis. Journal of the neurological sciences, 2007, Mar-15, Volume: 254, Issue:1-2 Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Catalytic Domain; Central Nervous System; Codon; Disease Progression; DNA Mutational Analysis; Fatal Outcome; Female; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Mutation, Missense; Superoxide Dismutase; Tyrosine	2007
MR spectroscopy evaluation and short-term outcome of olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2007, Volume: 21, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Transplantation; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Olfactory Bulb; Prospective Studies; Protons; Recovery of Function	2007
Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study. Journal of neurology, 2007, Volume: 254, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Aspartic Acid; Choline; Creatine; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Statistics, Nonparametric; Time Factors	2007
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience, 2007, Volume: 25, Issue:6 Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors	2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology, 2007, Apr-24, Volume: 68, Issue:17 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neuron Disease; Motor Neurons; Muscular Atrophy, Spinal; Neural Conduction; Prospective Studies; Transcranial Magnetic Stimulation	2007
Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis. Journal of the neurological sciences, 1995, Volume: 129, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Humans; Male; Middle Aged	1995
[3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. Brain research, 1994, Aug-29, Volume: 655, Issue:1-2 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Autoradiography; Female; Humans; Male; Middle Aged; Motor Neuron Disease; Motor Neurons; Muscular Atrophy, Spinal; Receptors, Amino Acid; Spinal Cord	1994
[Free amino acid contents in the spinal cord of amyotrophic lateral sclerosis]. Rinsho shinkeigaku = Clinical neurology, 1993, Volume: 33, Issue:9 Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Spinal Cord	1993
Changes in CSF amino acid concentrations during the evolution of amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry, 1994, Volume: 57, Issue:1 Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Humans; Male; Middle Aged; Severity of Illness Index	1994
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biological Transport, Active; Choline O-Acetyltransferase; Disease Models, Animal; Glutamates; Lumbosacral Region; Motor Neurons; Organ Culture Techniques; Pyrrolidonecarboxylic Acid; Rats; Receptors, Glutamate; Spinal Cord; Synaptic Transmission	1993
Altered metabolism of excitatory amino acids, N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis. Brain research bulletin, 1993, Volume: 30, Issue:3-4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Dipeptides; Humans; Middle Aged; Spinal Cord	1993
Reduced brain N-acetyl-aspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis. Neurological research, 1996, Volume: 18, Issue:3 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Death; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Male; Middle Aged	1996
Identification of brain metabolites by magnetic resonance spectroscopy in MND/ALS. Journal of the neurological sciences, 1996, Volume: 139 Suppl Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Chemistry; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy	1996
Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy. Neurology, 1997, Volume: 48, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebellum; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Muscular Atrophy, Spinal; Protons; Reference Values	1997
Increased CSF glutamate following injection of ALS immunoglobulins. Neurology, 1997, Volume: 48, Issue:5 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Glutamic Acid; Immunoglobulins; Injections, Intraperitoneal; Rats; Reference Values; Time Factors	1997
CuZn-superoxide dismutase, extracellular superoxide dismutase, and glutathione peroxidase in blood from individuals homozygous for Asp90Ala CuZu-superoxide dismutase mutation. Journal of neurochemistry, 1998, Volume: 70, Issue:2 Topics: Alanine; Alleles; Amyotrophic Lateral Sclerosis; Aspartic Acid; Erythrocytes; Genetic Carrier Screening; Genotype; Glutathione Peroxidase; Homozygote; Humans; Point Mutation; Superoxide Dismutase	1998
Quantification of brain metabolites in ALS by localized proton magnetic spectroscopy. Neurology, 1998, Volume: 50, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Motor Cortex; Organ Specificity; Reference Values	1998
Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology, 1998, Volume: 50, Issue:6 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Pyramidal Tracts; Reference Values; Tissue Distribution	1998
Expression, purification, and characterization of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant. Molecules and cells, 1998, Aug-31, Volume: 8, Issue:4 Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chelating Agents; Copper; Free Radicals; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Recombinant Fusion Proteins; Superoxide Dismutase	1998
A proton magnetic resonance spectroscopic study in ALS: correlation with clinical findings. Neurology, 1998, Volume: 51, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatinine; Humans; Magnetic Resonance Imaging; Middle Aged; Motor Cortex; Occipital Lobe; Parietal Lobe; Phosphocreatine; Protons	1998
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry. Neuroreport, 1998, Sep-14, Volume: 9, Issue:13 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Models, Animal; Hippocampus; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Neocortex; Neurofilament Proteins; Neurons; Phosphocreatine; Putamen; Thalamus; Ubiquitins	1998
The free radical-generating function of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant. Biochemistry and molecular biology international, 1998, Volume: 46, Issue:6 Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Free Radicals; Humans; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Superoxide Dismutase; Sweden	1998
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology, 1999, Jul-13, Volume: 53, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values	1999
Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS). Acta neurologica Scandinavica, 1999, Volume: 100, Issue:1 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Death; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glycine; Humans; Male; Middle Aged; Neurons; Neurotransmitter Agents; Severity of Illness Index	1999
Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology, 1999, Volume: 212, Issue:3 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neuron Disease; Motor Neurons; Pyramidal Tracts; Sensitivity and Specificity	1999
1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Journal of the neurological sciences, 1999, Oct-31, Volume: 169, Issue:1-2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Chemistry; Creatine; Humans; Magnetic Resonance Spectroscopy; Middle Aged	1999
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. Journal of neurochemistry, 2000, Volume: 74, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Cerebral Cortex; Extracellular Space; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydroxyindoleacetic Acid; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microdialysis; Phenotype; Superoxide Dismutase	2000
[Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2000, Volume: 100, Issue:7 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Electromyography; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons	2000
CuZn-superoxide dismutase gene in sporadic amyotrophic lateral sclerosis patients from Russia: Asp90Ala (D90A) mutation and novel rare polymorphism IVS3+35 A>C. Human mutation, 2000, Volume: 16, Issue:3 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Asian People; Aspartic Acid; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Polymorphism, Genetic; Russia; Superoxide Dismutase; Superoxide Dismutase-1	2000
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis. Archives of neurology, 2001, Volume: 58, Issue:5 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Phosphocreatine; Reference Values; Severity of Illness Index	2001
1H spectroscopy in patients with amyotrophic lateral sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2001, Volume: 11, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Statistics, Nonparametric	2001
Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis. Neuroradiology, 2001, Volume: 43, Issue:7 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neurons	2001
Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients. Journal of the neurological sciences, 2001, Sep-15, Volume: 190, Issue:1-2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Electric Stimulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons; Neural Conduction; Peripheral Nerves; Predictive Value of Tests; Pyramidal Cells; Transcranial Magnetic Stimulation	2001
Effect of creatine supplementation on metabolite levels in ALS motor cortices. Experimental neurology, 2001, Volume: 172, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria, Muscle; Motor Cortex; Reference Values	2001
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology, 2002, Mar-12, Volume: 58, Issue:5 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Reproducibility of Results	2002
Reduction in metabolite transverse relaxation times in amyotrophic lateral sclerosis. Journal of the neurological sciences, 2002, Jun-15, Volume: 198, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Stem; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Osmolar Concentration; Reference Values	2002
Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis. Acta neurologica Scandinavica, 1992, Volume: 86, Issue:5 Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biopsy; Collagen; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Reference Values; Skin	1992
[Familial amyotrophic lateral sclerosis associated with Huntington chorea with increased aspartate level in the cerebrospinal fluid]. Revue neurologique, 1992, Volume: 148, Issue:2 Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Humans; Huntington Disease; Middle Aged	1992
Excitatory amino acids in amyotrophic lateral sclerosis: an update. Annals of neurology, 1991, Volume: 30, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Humans; Prospective Studies	1991
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain research, 1991, Aug-09, Volume: 556, Issue:1 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Humans; Motor Cortex; Reference Values; Spinal Cord	1991
Excitatory amino acids in amyotrophic lateral sclerosis. Annals of neurology, 1991, Volume: 29, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Humans	1991
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of neurology, 1990, Volume: 28, Issue:1 Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Dipeptides; Female; Glutamates; Humans; Male; Middle Aged; Spinal Cord	1990
The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis. Annals of neurology, 1988, Volume: 24, Issue:3 Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cerebellar Cortex; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; Middle Aged; Neurotoxins; Reference Values; Spinal Cord	1988