aspartame and BH4 Deficiency

aspartame has been researched along with BH4 Deficiency in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (68.75)	18.7374
1990's	6 (18.75)	18.2507
2000's	2 (6.25)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (6.25)	2.80

Authors

Authors	Studies
Alili, JM; Goetz, V; Khalil, AE; Labarthe, F; Maillot, F; Maler, V; Meunier, P; Tardieu, M	1
Abeln, D; de Blaauw, P; Heiner-Fokkema, MR; Maatman, RGHJ; Melis, ES; van Dam, E; van Spronsen, FJ; van Vliet, K	1
Barceloux, DG; Rangan, C	1
Bauer-Nehrling, JK; Horwitz, DL	1
Yellowlees, H	1
Waggoner, WF	1
Wenz, E	1
Baker, GL; Blaskovics, ME; Filer, LJ; Koch, R; McDonnell, JE; Stegink, LD	1
Lines, DR	1
Baker, GL; Filer, LJ; McDonnell, JE; Stegink, LD	2
Blau, N; Curtius, HC; Endres, W	1
Benninger, C; Bickel, H; de Sonneville, L; Lanz-Englert, B; Matthis, P; Trefz, F	1
Coelho, JC; Giugliani, R; Jardim, LB; Pires, RF; Silva, LC	1
Carvalho, TS; da Silva, FB; da Silva, LC; Giugliani, R; Pereira, ML; Pires, RF	1
Haber, M; Koch, R; Shaw, KN; Williamson, M	1
Koch, R; Schaeffler, G; Shaw, NF	1
Berlin, CM; Mackey, SA	1
Bell, EF; Brummel, MC; Filer, LJ; Krause, WL; Persoon, TJ; Stegink, LD; Wolf-Novak, LC; Ziegler, EE	1
Bell, EF; Filer, LJ; Krause, WL; Stegink, LD; Tephly, TR; Ziegler, EE	1
Filer, LJ; Stegink, LD	1
Güttler, F; Lou, H	1
Bell, EF; Brummel, MC; Filer, LJ; Krause, WL; Stegink, LD; Wolf-Novak, LC; Ziegler, EE	1
Baker, GL; Bell, EF; Brummel, MC; Filer, LJ; Krause, WL; Stegink, LD; Ziegler, EE	1
Janssen, PJ; van der Heijden, CA	1
Drenth, JP; Kleinjans, JC	1
Freedman, M	1
Dews, PB	1
Bickel, H; Trefz, FK	1
Caballero, B; Levy, HL; Mahon, BE; Rohr, FJ; Wurtman, RJ	1

Reviews

3 review(s) available for aspartame and BH4 Deficiency

Article	Year
Food additives and sensitivities. Disease-a-month : DM, 2009, Volume: 55, Issue:5 Topics: Anti-Bacterial Agents; Antioxidants; Aspartame; Bronchiolitis Obliterans; Coloring Agents; Cyclamates; Diacetyl; Emulsifying Agents; Food Additives; Food Handling; Food Hypersensitivity; Food Microbiology; Food Preservatives; History, 20th Century; Humans; Methemoglobinemia; Nitrates; Nitrites; Phenylketonurias; Saccharin; Sodium Glutamate; Sulfites	2009
Can aspartame meet our expectations? Journal of the American Dietetic Association, 1983, Volume: 83, Issue:2 Topics: Aspartame; Diet, Reducing; Dipeptides; Drug Evaluation; Humans; Phenylketonurias; Structure-Activity Relationship; Sweetening Agents	1983
Aspartame: review of recent experimental and observational data. Toxicology, 1988, Volume: 50, Issue:1 Topics: Animals; Aspartame; Behavior, Animal; Brain Chemistry; Dipeptides; Humans; Phenylalanine; Phenylketonurias	1988

Trials

6 trial(s) available for aspartame and BH4 Deficiency

Article	Year
Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine). Human genetics, 1994, Volume: 93, Issue:4 Topics: Adolescent; Adult; Aspartame; Electroencephalography; Female; Heterozygote; Humans; Male; Mental Processes; Middle Aged; Neuropsychological Tests; Phenylketonurias	1994
Use of aspartame in phenylketonuric heteroxygous adults. Journal of toxicology and environmental health, 1976, Volume: 2, Issue:2 Topics: Adult; Aspartame; Clinical Trials as Topic; Dipeptides; Female; Heterozygote; Humans; Male; Middle Aged; Phenylalanine; Phenylketonurias; Placebos; Tyrosine	1976
Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients. Clinical pediatrics, 1992, Volume: 31, Issue:7 Topics: Adolescent; Adult; Aspartame; Body Weight; Child; Female; Homozygote; Humans; Male; Phenylalanine; Phenylketonurias; Sweetening Agents; Tyrosine	1992
Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria. Metabolism: clinical and experimental, 1990, Volume: 39, Issue:10 Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Beverages; Female; Heterozygote; Humans; Male; Methanol; Phenylalanine; Phenylketonurias	1990
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria. The Journal of nutrition, 1987, Volume: 117, Issue:11 Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Biological Transport; Dipeptides; Female; Glutamates; Glutamic Acid; Glutamine; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias; Tyrosine	1987
Repeated ingestion of aspartame-sweetened beverage: effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:1 Topics: Adult; Amino Acids; Aspartame; Beverages; Biological Transport; Dipeptides; Dose-Response Relationship, Drug; Female; Heterozygote; Humans; Male; Phenylalanine; Phenylketonurias; Random Allocation	1989

Other Studies

23 other study(ies) available for aspartame and BH4 Deficiency

Article	Year
Aspartame and Phenylketonuria: an analysis of the daily phenylalanine intake of aspartame-containing drugs marketed in France. Orphanet journal of rare diseases, 2023, 06-08, Volume: 18, Issue:1 Topics: Aspartame; France; Humans; Phenylalanine; Phenylketonurias	2023
Aspartame and Phe-Containing Degradation Products in Soft Drinks across Europe. Nutrients, 2020, Jun-24, Volume: 12, Issue:6 Topics: Aspartame; Carbonated Beverages; Chromatography, Liquid; Diketopiperazines; Dipeptides; Europe; Food Safety; Humans; Limit of Detection; Phenylalanine; Phenylketonurias; Reproducibility of Results; Tandem Mass Spectrometry	2020
Aspartame. British medical journal (Clinical research ed.), 1983, Sep-24, Volume: 287, Issue:6396 Topics: Aspartame; Dipeptides; Government Agencies; Humans; Phenylketonurias; United Kingdom	1983
Aspartame--a review. Pediatric dentistry, 1984, Volume: 6, Issue:3 Topics: Animals; Aspartame; Brain Diseases; Brain Neoplasms; Child; Dental Caries; Dipeptides; Humans; Phenylalanine; Phenylketonurias; United States; United States Food and Drug Administration	1984
Aspartame and PKU. Journal of the American Dietetic Association, 1984, Volume: 84, Issue:1 Topics: Adult; Aspartame; Child; Dipeptides; Female; Humans; Phenylketonurias; Pregnancy	1984
Plasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight. Toxicology, 1981, Volume: 20, Issue:1 Topics: Adult; Aspartame; Aspartic Acid; Dipeptides; Female; Heterozygote; Humans; Male; Phenylalanine; Phenylketonurias; Sex Factors; Tyrosine	1981
Aspartame doses for phenylketonuria. The Journal of nutrition, 1981, Volume: 111, Issue:9 Topics: Aspartame; Child; Dipeptides; Dose-Response Relationship, Drug; Female; Fetus; Humans; Phenylketonurias; Pregnancy; Pregnancy Complications	1981
Effect of an abuse dose of aspartame upon plasma and erythrocyte levels of amino acids in phenylketonuric heterozygous and normal adults. The Journal of nutrition, 1980, Volume: 110, Issue:11 Topics: Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Dose-Response Relationship, Drug; Erythrocytes; Female; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias	1980
Effect of high-protein meal plus aspartame ingestion on plasma phenylalanine concentrations in obligate heterozygotes for phenylketonuria. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:4 Topics: Adult; Aspartame; Brain; Dietary Proteins; Female; Heterozygote; Humans; Male; Middle Aged; Phenylalanine; Phenylketonurias	1994
Evaluation of an aspartame loading test for the detection of heterozygotes for classical phenylketonuria. Clinical genetics, 1997, Volume: 51, Issue:4 Topics: Aspartame; Evaluation Studies as Topic; Female; Genetic Carrier Screening; Humans; Male; Phenylketonurias	1997
Aspartame loading test in PKU heterozygous individuals bearing severe and moderate mutations. Clinical genetics, 2000, Volume: 58, Issue:1 Topics: Aspartame; DNA; DNA Mutational Analysis; Heterozygote; Humans; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine	2000
Effect of aspartame loading upon plasma and erythrocyte amino acid levels in phenylketonuric heterozygotes and normal adult subjects. The Journal of nutrition, 1979, Volume: 109, Issue:4 Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Erythrocytes; Female; Heterozygote; Humans; Male; Phenylalanine; Phenylketonurias	1979
Results of loading doses of aspartame by two phenylketonuric (PKU) children compared with two normal children. Journal of toxicology and environmental health, 1976, Volume: 2, Issue:2 Topics: Adolescent; Aspartame; Child; Dipeptides; Female; Glutamine; Humans; Male; Phenylacetates; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Tyrosine	1976
Synthetic sweetners: cyclamates, saccharin, aspartame. The Medical letter on drugs and therapeutics, 1975, Jul-18, Volume: 17, Issue:15 Topics: Animals; Aspartame; Aspartic Acid; Beverages; Cyclamates; Cyclohexylamines; Diet, Reducing; Dipeptides; Female; Fetus; Food; Humans; Maternal-Fetal Exchange; Mice; Phenylketonurias; Piperazines; Placenta; Polyps; Pregnancy; Primates; Rats; Saccharin; United States; United States Food and Drug Administration; Urinary Bladder Neoplasms; Uterine Neoplasms	1975
Aspartame ingestion with and without carbohydrate in phenylketonuric and normal subjects: effect on plasma concentrations of amino acids, glucose, and insulin. Metabolism: clinical and experimental, 1990, Volume: 39, Issue:4 Topics: Adolescent; Amino Acids; Aspartame; Beverages; Blood Glucose; Diet; Dipeptides; Female; Humans; Insulin; Kinetics; Male; Phenylketonurias; Reference Values; Time Factors	1990
Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects. Diabetes care, 1989, Volume: 12, Issue:1 Topics: Adult; Aspartame; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Erythrocytes; Female; Glucagon; Heterozygote; Humans; Insulin; Lipids; Male; Methanol; Phenylalanine; Phenylketonurias; Reference Values	1989
Aspartame may imperil dietary control of phenylketonuria. Lancet (London, England), 1985, Mar-02, Volume: 1, Issue:8427 Topics: Aspartame; Child; Dipeptides; Humans; Phenylalanine; Phenylketonurias	1985
Aspartame. Review of safety issues. Council on Scientific Affairs. JAMA, 1985, Jul-19, Volume: 254, Issue:3 Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Carbonated Beverages; Carcinogens; Child; Dietary Carbohydrates; Diketopiperazines; Dipeptides; Drug Stability; Endocrine System Diseases; Female; Glutamates; Glutamic Acid; Humans; Infant; Intellectual Disability; Methanol; Mice; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Piperazines; Pregnancy; Rats	1985
[Aspartame, a sweet alternative]. Nederlands tijdschrift voor geneeskunde, 1988, Apr-16, Volume: 132, Issue:16 Topics: Adolescent; Adult; Animals; Aspartame; Carcinogens; Child; Child, Preschool; Dipeptides; Energy Intake; Energy Metabolism; Humans; Phenylalanine; Phenylketonurias; Rats	1988
Consumption of aspartame by heterozygotes for phenylketonuria. The Journal of pediatrics, 1987, Volume: 110, Issue:4 Topics: Aspartame; Dipeptides; Female; Fetal Diseases; Heterozygote; Humans; Phenylalanine; Phenylketonurias; Pregnancy	1987
Summary report of an International Aspartame Workshop. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:7 Topics: Animals; Aspartame; Biotransformation; Dipeptides; Female; Humans; Phenylalanine; Phenylketonurias; Pregnancy	1987
[Aspartame: a sweetening agent with a high phenylalanine content]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:7 Topics: Aspartame; Child; Dipeptides; Genetic Carrier Screening; Humans; Phenylalanine; Phenylketonurias; Risk	1986
Plasma amino acid levels after single-dose aspartame consumption in phenylketonuria, mild hyperphenylalaninemia, and heterozygous state for phenylketonuria. The Journal of pediatrics, 1986, Volume: 109, Issue:4 Topics: Amino Acids; Aspartame; Dipeptides; Heterozygote; Humans; Phenylalanine; Phenylketonurias	1986