asparagine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 81 studies
*Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.23) | 18.7374 |
| 1990's | 10 (12.35) | 18.2507 |
| 2000's | 23 (28.40) | 29.6817 |
| 2010's | 29 (35.80) | 24.3611 |
| 2020's | 18 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, WH | 1 |
| Abdel-Fattah, M; Ataya, FS; El-Nikhely, N; Eldoksh, A; Elkewedi, M; Elsawy, E; Hemida, A; Labrou, NN; Nematalla, H; Saeed, H; Shalaby, M | 1 |
| Andreoli, R; Bardelli, D; Bianchi, MG; Biondi, A; Bussolati, O; Carubbi, C; Chiu, M; D'Amico, G; Dander, E; Fallati, A; Galuppo, L; Mirandola, P; Pozzi, G; Rizzari, C; Tardito, S; Taurino, G | 1 |
| Chan, WK; Chiche, J; Grima-Reyes, M; Lorenzi, PL; Marchetti, S; Martinez-Turtos, A; Meola, P; Nemazanyy, I; Nottet, N; Paul, R; Reverso-Meinietti, J; Ricci, JE; Vandenberghe, A | 1 |
| Darvishi, F; Jahanafrooz, Z; Mokhtarzadeh, A | 1 |
| Bakkali, A; Brigitha, LJ; Pieters, R; Struys, EA; van der Sluis, IM | 1 |
| Chan, WK; De Moerloose, B; De Visser, Y; Goossens, S; Lammens, T; Lavie, A; Lee, H; Lorenzi, PL; Mondelaers, V; Nguyen, HA; Peeters, E; Reunes, L; Schalk, AM; Su, Y; Van Trimpont, M; Van Vlierberghe, P; Vandemeulebroecke, K | 1 |
| Beltrán, JF; Castillo, RL; Farías, JG; Herrera Belén, L; Pedroso, A; Pedroso, E; Pessoa, A | 1 |
| Aidarova, S; Lanka, SS; Mutaliyeva, B; Sharipova, A; Suigenbayeva, A; Talluri, VP; Tleuova, A; Ulaganathan, V | 1 |
| Andjelkovic, M; Ramos-Guzmán, CA; Ruiz-Pernía, JJ; Tuñón, I; Zinovjev, K | 1 |
| Akahane, K; Goi, K; Goto, H; Harama, D; Inukai, T; Kagami, K; Kasai, S; Kitahara, S; Miyake, K; Sakaguchi, K; Sunamura, EI; Tamai, M; Watanabe, A; Yamada, Y; Yotani, T | 1 |
| Attarbaschi, A; Boos, J; Gerss, J; Lanvers-Kaminsky, C; Möricke, A; Nath, C; Rizzari, C; Schrappe, M; Smisek, P; Stary, J; Würthwein, G; Zimmermann, M; Zucchetti, M | 1 |
| Afzal, M; Azeem, F; Muneer, F; Muzammil, S; Nadeem, H; Rasul, I; Siddique, MH; Zubair, M | 1 |
| Alcaro, S; Coricello, A; Radadiya, A; Richards, NGJ; Zhu, W | 1 |
| Daley, RJ; Geyer, MB; Kabel, CC; Lavery, JA; Pappacena, JJ; Park, JH; Rajeeve, S; Stump, SE; Tallman, MS | 1 |
| Florindo Guedes, MI; Freire, DA; Lisboa Magalháes, IC; Tramontina Florean, EOP | 1 |
| Almeida, MR; Bento, HBS; Castro, D; de Paiva, GB; Freire, MG; Marques, ASC; Pedrolli, DB; Santos-Ebinuma, VC; Tavares, APM | 1 |
| Bielawski, JP; Cohen, A; Connors, J; Dunn, KA; Forbrigger, Z; Kulkarni, K; Langille, MGI; MacDonald, T; Penny, SL; Rahman, M; Stadnyk, AW; Van Limbergen, J | 1 |
| Bostrom, B; Marini, B; Messinger, Y; Perissinotti, AJ; Salzer, W | 1 |
| Ardalan, N; Khavari-Nejad, RA; Mirzaie, S; Sepahi, AA | 1 |
| Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Shiromizu, S | 1 |
| Acquaviva-Bourdain, C; Audrain, M; Boissel, N; Dombret, H; Huguet, F; Hunault-Berger, M; Ifrah, N; Leguay, T; Lheritier, V; Pagan, C; Paillassa, J; Thomas, X; Vianey-Saban, C | 1 |
| Fang, Y; Shen, Y; Wang, R; Wang, Y; Webster, TJ; Xu, J; Zhang, Y | 1 |
| Almeida, RV; Bon, EPDS; Ferrara, MA; Gregório Alves Fontão, AP; Jurgilas, PB; Lopes, W; Nascimento, HJ; Sampaio, ALF; Santos, BAFD; Torres, FAG | 1 |
| Abrahamsson, J; Albertsen, BK; Frandsen, TL; Grell, K; Heyman, M; Jónsson, ÓG; Lund, B; Schmiegelow, K; Vettenranta, K; Wolthers, BO | 1 |
| Al-Abodi, HR; Al-Marzoqi, AH; Alghanimi, YK; Fattahi, A; Ghasemian, A; Kadhum, SA; Shokouhi Mostafavi, SK | 1 |
| Fukuda, T; Hayase, T; Kashii, Y; Kawahara, Y; Momoi, MY; Morimoto, A | 1 |
| Keating, GM | 1 |
| Hop, WC; Pieters, R; Tong, WH; van der Sluis, IM | 1 |
| Bussolati, O; Chiu, M; D'Amico, G; Dell'Acqua, F; Franchi-Gazzola, R; Rizzari, C | 1 |
| Albertsen, BK; Frandsen, TL; Henriksen, LT; Nersting, J; Raja, RA; Rosthøj, S; Schrøder, H | 1 |
| Jiang, B; Mu, W; Zhang, T; Zuo, S | 1 |
| Asselin, B; Rizzari, C | 1 |
| Béné, MC; Bonmati, C; Bories, P; Boulland, ML; Bouscary, D; Chevallier, P; Deconinck, E; Dombret, H; Escoffre-Barbe, M; Godfrin, Y; Himberlin, C; Huguet, F; Hunault-Berger, M; Ifrah, N; Lafage-Pochitaloff, M; Legrand, O; Leguay, T; Leprêtre, S; Liens, D; Lissandre, S; Ojeda-Uribe, M; Reman, O; Rousselot, P; Sanhes, L; Turlure, P | 1 |
| Banerji, J | 1 |
| Afanetti, M; Boyer, C; Pardes-Chavanes, P; Poirée, M | 1 |
| Carr, D; Dallapozza, L; Earl, JW; Eslick, AE; Misra, A; Nath, CE | 1 |
| Wang, ES; Wetzler, M; Zeidan, A | 1 |
| Cheng, C; Gajjar, A; Hak, LJ; Hijiya, N; Liu, W; Panetta, JC; Pui, CH; Relling, MV | 1 |
| Audrain, M; Bouige, D; Corradini, N; Legrand, A; Mansuy, A; Méchinaud, F; Mohty, M; Orsonneau, JL; Rozé, JC; Strullu, M; Thomare, P; Vermot-Desroches, C | 1 |
| Gu, LJ; He, YY; Jiang, H; Li, BS; Luo, CY | 1 |
| Cannas, G; Chelghoum, Y; Gougounon, A; Thomas, X | 1 |
| Raetz, EA; Salzer, WL | 1 |
| Bussolati, O; Chiarelli, LR; Covini, D; Digilio, R; Pasquetto, MV; Scotti, C; Tardito, S; Valentini, G | 1 |
| Doble, M; Ln, R; Pulicherla, KK; Rekha, VP | 1 |
| Koltin, D; Naqvi, A; Sung, L; Urbach, SL | 1 |
| Attarbaschi, A; Dworzak, MN; Haas, OA; Hochreiter, D; Hutter, C; Kasper, DC; Kornmüller, R; Mann, G; Pichler, H; Pötschger, U; Steiner, M | 1 |
| Ahn, YM; Hegazy, L; Hiratake, J; Ikeuchi, H; Otokawa, T; Richards, NG; Watanabe, B | 1 |
| Boos, J; Hop, WC; Lanvers-Kaminsky, C; Pieters, R; Tong, WH; van der Sluis, IM | 1 |
| Kataria, M; Kumar, K; Verma, N | 1 |
| Boos, J; Lanvers, C; Pinheiro, JP; Würthwein, G | 1 |
| Langebrake, C; Reinhardt, D; Ritter, J | 1 |
| Appel, IM; Boos, J; den Boer, ML; Lanvers, C; Pieters, R; Pinheiro, JP; Reniers, NC | 1 |
| Arnold, R; Boos, J; Gökbuget, N; Hähling, D; Hartmann, F; Hoelzer, D; Ittel, TH; Langer, W; Mück, R; Müller, HJ; Peter, N; Rosen, O; Rothmann, F; Schwartz, S | 1 |
| Chin, M; Higa, T; Hori, T; Iwai, A; Kuno, T; Maeba, H; Muto, A; Nomura, K; Taga, T; Tsurusawa, M; Yamagata, M | 1 |
| Bodalski, J; Kowalewska-Pietrzak, M; Przybysz, K; Stolarska, M; Zalewska-Szewczyk, B | 1 |
| Bresciani, P; Ferrari, A; Luppi, M; Morselli, M; Potenza, L; Riva, G; Saviola, A; Torelli, G | 1 |
| Avramis, VI; Felgenhauer, JL; Hawkins, DS; Holcenberg, JS; Panosyan, EH; Park, JR; Thomson, BG | 1 |
| Chen, FX; Cui, YQ; Guan, JM; Lai, YH; Lu, CY; Wei, FG; Wu, ZL; Ye, TZ; Zhang, H; Zou, YW | 1 |
| Altman, A; Avramis, VI; Bostrom, B; Breneman, J; Fu, C; Gaynon, PS; Harris, RE; Jarrar, M; Periclou, AP; Steele, D; Stram, D; Trigg, M; Zipf, T | 1 |
| Belevtsev, MV; Buglova, SE; Shman, TV | 1 |
| Kilberg, MS; Richards, NG | 1 |
| Bloomfield, CD; DeOliveira, D; Frankel, SR; Kolitz, JE; Kurtzberg, J; Larson, RA; Powell, BL; Sanford, BL; Wetzler, M | 1 |
| Campana, D; Downing, JR; Iwamoto, S; Mihara, K; Pui, CH | 1 |
| Andrzejewski, W; Bodalski, J; Jedrychowska-Dańska, K; Młynarski, W; Witas, H; Zalewska-Szewczyk, B | 1 |
| Williams, DA | 1 |
| Cohen, MH; Dinndorf, PA; Gootenberg, J; Keegan, P; Pazdur, R | 1 |
| Bode, U; Boos, J; Fleischhack, G; Jürgens, H; Nowak-Göttl, U | 1 |
| Di Cataldo, A; Dibenedetto, SP; Lo Nigro, L; Meli, C; Ragusa, R | 1 |
| Sugimura, K; Sukemori, S | 2 |
| Conter, V; D'Incalci, M; Gentili, D; Masera, G; Zucchetti, M | 1 |
| Boehlein, SK; Dribben, AB; Parr, IB; Richards, NG; Schuster, SM | 1 |
| Ahlke, E; Boos, J; Jürgens, H; Nowak-Göttl, U; Ritter, J; Schulze-Westhoff, P; Verspohl, EJ; Werber, G; Würthwein, G | 1 |
| Boos, J | 1 |
| Ahlke, E; Boos, J; Fleischhack, G; Hempel, G; Lümkemann, K; Mann, G; Müller, HJ; Nowak-Göttl, U; Rath, B; Schrappe, M; Vieira Pinheiro, JP | 1 |
| Gajjar, AJ; Hak, LJ; Harrison, PL; Pui, CH; Relling, MV; Sandlund, JT; Storm, MC; Wang, B; Woo, MH | 1 |
| Aricò, M; Bruno, A; Conter, V; D'Incalci, M; Diomede, L; Gavazzi, L; Lo Nigro, L; Milani, M; Paganini, M; Rizzari, C; Sparano, P; Zucchetti, M | 1 |
| Albertsen, BK; Carlsen, NT; Jakobsen, P; Müller, HJ; Schmiegelow, K; Schrøder, H | 1 |
| Albertsen, BK; Avramis, VI; Carlsen, NT; Ingerslev, J; Jakobsen, P; Müller, HJ; Schmiegelow, K; Schrøder, H | 1 |
| Cheung, RK; Gelfand, EW; Lee, JW; Narasimhan, S; Schachter, H | 1 |
16 review(s) available for asparagine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Microbial L-asparaginase as a promising enzyme for treatment of various cancers.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacteria; Escherichia coli; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
L-Asparaginase delivery systems targeted to minimize its side-effects.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Microbial L-asparaginase: purification, characterization and applications.
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Hodgkin Disease; Humans; Phylogeny; Plants; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
L-asparaginase production review: bioprocess design and biochemical characteristics.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Biotechnology; Dickeya chrysanthemi; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2021 |
Asparaginase activity levels and monitoring in patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Drug Monitoring; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2018 |
Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Escherichia coli; Glutamine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombination, Genetic | 2019 |
Recent research progress on microbial L-asparaginases.
Topics: Acrylamide; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Humans; Hydrolysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Asparaginase pharmacokinetics and implications of therapeutic drug monitoring.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Drug Monitoring; Enzyme Activation; Glutamine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2015 |
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Codon; Gene Expression Regulation; Humans; Peptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Biosynthesis; Ribosomes | 2015 |
Pegasparaginase: where do we stand?
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Drug Hypersensitivity; Drug Resistance, Neoplasm; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
[Therapeutic alternatives to native L-asparaginase in the treatment of adult acute lymphoblastic leukemia].
Topics: Adult; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Dickeya chrysanthemi; Drug Carriers; Drug Interactions; Erythrocytes; Escherichia coli; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Tolerability and efficacy of L-asparaginase therapy in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparagine; Child; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Expanding targets for a metabolic therapy of cancer: L-asparaginase.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Drug Delivery Systems; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Minimising the long-term adverse effects of childhood leukaemia therapy.
Topics: Alkylating Agents; Anthracyclines; Antimetabolites; Antineoplastic Agents; Asparaginase; Asparagine; Cardiovascular Diseases; Child; Clinical Trials as Topic; Glucocorticoids; Gonadal Disorders; Humans; Leukemia; Leukemia, Myeloid, Acute; Osteonecrosis; Podophyllotoxin; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tretinoin; Vinca Alkaloids | 2002 |
Asparagine synthetase chemotherapy.
Topics: Antineoplastic Agents; Asparagine; Aspartate-Ammonia Ligase; Binding Sites; Cell Cycle; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured | 2006 |
12 trial(s) available for asparagine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Infant; Male; Osteonecrosis; Pancreatitis; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Risk; Thromboembolism; Treatment Outcome | 2019 |
A Phase 2 study of L-asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: The GRASPALL/GRAALL-SA2-2008 study.
Topics: Aged; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Drug Carriers; Drug Compounding; Erythrocytes; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Male; Middle Aged; Mycoses; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Analysis | 2015 |
Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia.
Topics: Antibodies; Antineoplastic Agents; Asparaginase; Asparagine; Computer Simulation; Escherichia coli; Humans; Models, Biological; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Recurrence; Treatment Failure | 2009 |
Silent hypersensitivity to Escherichia coli asparaginase in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antibodies, Anti-Idiotypic; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate | 2010 |
No evidence of increased asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
L-Asparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Feasibility Studies; Humans; Immunophenotyping; Middle Aged; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome | 2007 |
FDA drug approval summary: pegaspargase (oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL).
Topics: Antibodies; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Disease-Free Survival; Drug Approval; Female; Humans; Infant; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; United States; United States Food and Drug Administration | 2007 |
Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Erwinia; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors | 1995 |
Pharmacokinetics and drug monitoring of L-asparaginase treatment.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Monitoring; Erwinia; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism | 1997 |
L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Escherichia coli; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2000 |
Monitoring of Erwinia asparaginase therapy in childhood ALL in the Nordic countries.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Infant; Injections, Intramuscular; Injections, Intravenous; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Scandinavian and Nordic Countries | 2001 |
53 other study(ies) available for asparagine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Comment on "Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase".
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
L-asparaginase from
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Dickeya chrysanthemi; Escherichia coli; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats | 2022 |
ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment.
Topics: Asparaginase; Asparagine; Bone Marrow Cells; Humans; Mesenchymal Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Line, Tumor; Glutaminase; Lymphoma, B-Cell; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Microenvironment | 2022 |
Depletion of d- and l-asparagine in cerebrospinal fluid in acute lymphoblastic leukemia during PEGasparaginase therapy.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Glutamine; Humans; Infant; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Topics: Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Glutaminase; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
In Silico Design of a Chimeric Humanized L-asparaginase.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Fusion Proteins | 2023 |
Elucidation of the Active Form and Reaction Mechanism in Human Asparaginase Type III Using Multiscale Simulations.
Topics: Animals; Asparaginase; Asparagine; Humans; Mammals; Multienzyme Complexes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Subunits | 2023 |
Utility of
Topics: Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA Methylation; Humans; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Inactivation, Metabolic; Infant; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Improving the Treatment of Acute Lymphoblastic Leukemia.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Glutaminase; Humans; Medical Oncology; Models, Molecular; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Quality Improvement; Young Adult | 2020 |
Tolerability and toxicity of pegaspargase in adults 40 years and older with acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Agents; Asparaginase; Asparagine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Genes, Bacterial; Glutamic Acid; Glutamine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Catalytic Domain; Drug Design; Escherichia coli Proteins; Glutamine; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutation, Missense; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Protein Conformation; Quantum Theory; Substrate Specificity; Thermodynamics | 2018 |
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Drug Chronotherapy; Female; Humans; Infusions, Intravenous; Mice, Inbred BALB C; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
Monitoring of asparagine depletion and anti-L-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial.
Topics: Asparaginase; Asparagine; Child; Clinical Trials, Phase III as Topic; Female; Humans; Isoantibodies; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
Personalized nanomedicine: a rapid, sensitive, and selective UV-vis spectrophotometry method for the quantification of nanostructured PEG-asparaginase activity in children's plasma.
Topics: Asparaginase; Asparagine; Child; Humans; Hydrolysis; Limit of Detection; Nanomedicine; Nanostructures; Polyethylene Glycols; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2018 |
Expression, purification, and characterization of asparaginase II from Saccharomyces cerevisiae in Escherichia coli.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Bacterial Proteins; Cell Line, Tumor; Cloning, Molecular; Escherichia coli; Gene Expression; Glutamine; Humans; Molecular Weight; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Saccharomyces cerevisiae | 2019 |
Monitoring of anti-L-asparaginase antibody and L-asparaginase activity levels in a pediatric patient with acute lymphoblastic leukemia and hypersensitivity to native Escherichia coli L-asparaginase during desensitization courses.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Asparaginase Erwinia chrysanthemi (Erwinaze®): a guide to its use in acute lymphoblastic leukemia in the USA.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Bacterial Proteins; Drug Hypersensitivity; Drug Monitoring; Drugs, Investigational; Enzyme Therapy; Erwinia; Escherichia coli Proteins; Humans; Injections, Intramuscular; Polyethylene Glycols; Practice Guidelines as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States | 2013 |
Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Asparaginase; Asparagine; Bone Marrow; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Asparaginase; Asparagine; Bone Marrow; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Cerebrospinal fluid asparagine depletion during pegylated asparaginase therapy in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; Female; Glutamine; Humans; Infant; Injections, Intramuscular; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Specimen Handling | 2014 |
[Fatal central nervous system hemorrhage during acute lymphoblastic leukemia induction].
Topics: Antineoplastic Agents; Asparagine; Child; Fatal Outcome; Female; Humans; Intracranial Hemorrhages; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Stability; Escherichia coli Proteins; Fluorescence; Glutamic Acid; Glutamine; Homoserine; Humans; Least-Squares Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
[Relationship between the antileukemic activity of L-asparaginase and Asn level around leukemic cells].
Topics: Asparaginase; Asparagine; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Humans; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Topics: Asparaginase; Asparagine; Catalytic Domain; Child; Computer Simulation; Drug Design; Glutaminase; Glutamine; Humans; Ligands; Mutagenesis, Site-Directed; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Engineering | 2011 |
Medication induced diabetes during induction in pediatric acute lymphoblastic leukemia: prevalence, risk factors and characteristics.
Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Asparagine; Child; Child, Preschool; Confidence Intervals; Dexamethasone; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Induction Chemotherapy; Infant; Male; Odds Ratio; Ontario; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Factors; Vincristine | 2012 |
Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during Berlin-Frankfurt-Münster-based induction therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Child; Child, Preschool; Daunorubicin; Drug Administration Schedule; Female; Glutamic Acid; Glutamine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Treatment Outcome; Vincristine | 2012 |
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Topics: Amidohydrolases; Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Imines; Models, Molecular; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sulfur Compounds | 2012 |
Plant asparaginase-based asparagine biosensor for leukemia.
Topics: Agar; Alginates; Asparaginase; Asparagine; Biosensing Techniques; Color; Gelatin; Glucuronic Acid; Hexuronic Acids; Humans; Immobilized Proteins; Limit of Detection; Plant Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sepharose; Time Factors | 2013 |
Pharmacology of PEG-asparaginase in childhood acute lymphoblastic leukemia (ALL).
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Escherichia coli; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recombinant Proteins | 2002 |
Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Humans; Injections, Intravenous; Metabolic Clearance Rate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2003 |
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Blood Coagulation; Drug Administration Schedule; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2003 |
[Iatrogenic hyperlipidemia after l-asparaginase and glucocorticoid treatment in two children with acute lymphoblastic leukemia].
Topics: Adolescent; Anti-Inflammatory Agents; Asparagine; Female; Humans; Hyperlipidemias; Iatrogenic Disease; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2003 |
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Daunorubicin; Echocardiography; Humans; Male; Myocardial Ischemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vincristine | 2004 |
Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Delayed-Action Preparations; Female; Glutamine; Humans; Immunophenotyping; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2004 |
[Research on the pharmacokinetics and pharmacodynamics of L-asparaginase during its treatment of childhood acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2005 |
Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941).
Topics: Antibody Formation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Female; Glutamic Acid; Humans; Injections, Intramuscular; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Statistics, Nonparametric | 2006 |
[Drug sensitivity of tumor cells in varieties of acute childhood leukemia].
Topics: Antigens, CD34; Antineoplastic Agents; Apoptosis; Asparagine; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tumor Cells, Cultured; Vincristine | 2005 |
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Bone Marrow Cells; Cell Division; Child; Gene Expression Profiling; Humans; Mesenchymal Stem Cells; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
The anti-asparagines antibodies correlate with L-asparagines activity and may affect clinical outcome of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antibodies; Asparagine; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Immunoglobulin G; Immunoglobulin M; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Treatment Outcome | 2007 |
A new mechanism of leukemia drug resistance?
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Bone Marrow Cells; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Mesenchymal Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Loss of activity of Erwinia asparaginase on repeat applications.
Topics: Asparaginase; Asparagine; Child; Erwinia; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
Inhibition of cultured leukemia cell growth by enhanced adriamycin cytotoxicity with reduction of glutamine or asparagine level in medium.
Topics: Animals; Asparagine; Cell Division; Culture Media; Doxorubicin; Glutamine; Humans; Leukemia P388; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Tumor Cells, Cultured | 1994 |
Determination of L-asparagine in biological samples in the presence of L-asparaginase.
Topics: Asparaginase; Asparagine; Benzenesulfonates; Chromatography, High Pressure Liquid; Drug Stability; Erwinia; Erythrocytes; Freezing; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Salicylates; Sensitivity and Specificity | 1994 |
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Topics: Alkylation; Antineoplastic Agents; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Bacterial Proteins; Binding Sites; Drug Design; Enzyme Inhibitors; Escherichia coli; Glutamine; Humans; Isoenzymes; Kinetics; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1996 |
Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Pharmacokinetic dose adjustment of Erwinia asparaginase in protocol II of the paediatric ALL/NHL-BFM treatment protocols.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Erwinia; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Female; Humans; Infant; Injections, Intramuscular; Likelihood Functions; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1999 |
Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system.
Topics: Absorption; Antibodies; Asparaginase; Asparagine; Bacterial Proteins; Biological Availability; Blood Coagulation; Child; Dose-Response Relationship, Drug; Erwinia; Escherichia coli; Humans; Injections, Intramuscular; Liver; Liver Function Tests; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Remission Induction | 2001 |
Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III activity in human B and T lymphocyte lines and in tonsillar B and T lymphocytes.
Topics: Acetylglucosamine; Asparagine; B-Lymphocytes; Cell Line, Transformed; Glucosyltransferases; Herpesvirus 4, Human; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mannose; Methylation; N-Acetylglucosaminyltransferases; Oligosaccharides; Palatine Tonsil; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes; Tumor Cells, Cultured | 1988 |