asparagine and Neoplasms

asparagine has been researched along with Neoplasms in 69 studies

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199033 (47.83)18.7374
1990's2 (2.90)18.2507
2000's11 (15.94)29.6817
2010's16 (23.19)24.3611
2020's7 (10.14)2.80

Authors

AuthorsStudies
Batra, S; Chen, C; Davé, U; Fan, J; Jiang, J; Kapur, R; Liu, Y; Misra, J; Seim, G; Srivastava, S; Staschke, KA; Wek, RC; Zhang, C; Zhang, J; Zhong, M; Zhou, J; Zhou, L1
Hlozkova, K; Safrhansova, L; Starkova, J1
Oda, K; Wlodawer, A1
Adams, CM; Cassel, TA; Chen, X; Fan, TW; Gnanaprakasam, JNR; Higashi, RM; Kang, S; Kushwaha, B; Lane, AN; Li, Z; Liu, L; Scott, DA; Wang, R; Wang, T; Xin, G; Yang, J; Zhang, J1
Cinar, B; Dolgner, T; Fehlhaber, B; Forster, M; Hinze, L; Ibrahim, NK; Loxha, L; Niessen, J; Schreek, S; Stanulla, M; Stasche, AS1
Chang, JH; Mou, CY; Mou, KY1
Jiao, S; Wang, J; Wang, M; Wang, R; Wang, S; Zhang, J; Zhang, M1
Harada, Y; Kizuka, Y; Ohkawa, Y; Taniguchi, N1
Christofk, HR; Halbrook, CJ; Knott, SRV; Krall, AS; Lyssiotis, CA; Mittelman, SD; Momcilovic, M; Mullen, PJ; Schmid, EW; Shackelford, DB; Surjono, F; Thambundit, A1
Bailly, C; Vergoten, G1
Eoh, H; Gao, SJ; Jung, JU; Lee, JJ; Li, T; Lu, C; Ramos da Silva, S; Zhu, Y1
Ho, M; Lemichez, E; Mettouchi, A; Wilson, BA1
Bitencourt-Ferreira, G; de Azevedo, WF; Souto, AA; Volkart, PA1
Hay, N; Terry, AR1
Ann, J; Apfel, V; Barretina, J; Clish, CB; Deik, A; Galli, GG; Garraway, LA; Ghandi, M; Giannakis, M; Gopal, S; Hahn, WC; Hernandez, D; Keskula, P; Kryukov, GV; Li, H; Ning, S; Pagliarini, RA; Pierce, K; Root, DE; Schreiber, SL; Sellers, WR; Shkoza, D; Souza, A; Tsherniak, A; Vazquez, F; Zou, Y1
Balasubramanian, MN; Butterworth, EA; Kilberg, MS1
Chen, CY; Chen, HY; Chen, KB; Chen, KC1
Chen, CY; Chen, HY; Chen, KC; Lee, WY1
Cooper, AJ; Denton, TT; Deryabina, YI; Dorai, T; Isakova, EP; Krasnikov, BF; Pinto, JT; Shurubor, YI1
Kim, HD; Kim, J; Kim, Y; Lee, MS1
Fellinger, K; Gires, O; Hofmann, T; Munz, M; Schmitt, B1
Bogyo, M; Lee, J1
ERRERA, M; GREENSTEIN, JP1
Bussolati, O; Chiarelli, LR; Covini, D; Digilio, R; Pasquetto, MV; Scotti, C; Tardito, S; Valentini, G1
Li, C; Thompson, CB1
Ando, M; Hanioka, N; Jinno, H; Kaniwa, N; Minami, H; Ohtsu, A; Ozawa, S; Saeki, M; Sai, K; Saijo, N; Saito, Y; Sawada, J; Shirao, K; Tanaka-Kagawa, T; Yoshida, T1
MCCOY, TA; NEUMAN, RE1
MCCOY, TA; ORR, GR; PATTERSON, MK1
CHRISTENSEN, HN1
LORINCZ, AB; RYAN, WL1
SCHINDLER, R2
MASHBURN, LT; WRISTON, JC1
CONWAY, E; MCCOY, TA; PATTERSON, MK; WHITTLE, W1
KOEHLER, L; NIEPER, HA1
NIEPER, HA1
Fujii, Y; Fujimoto, Z; Horii, K; Mizuno, H; Morita, T; Okuda, D1
Friedman, M1
Gobel, BH1
Cohen, AD; Duan, F; Engelhorn, ME; Guevara-Patiño, JA; Houghton, AN; Liu, C; Merghoub, T; Rizzuto, G; Turk, MJ; Wolchok, JD1
Bronson, R; Edelmann, W; Fan, K; Kucherlapati, M; Kucherlapati, R; Kuraguchi, M; Lipkin, M; Nguyen, A; Wei, K; Yang, K1
Asahi, M; Lee, SH; Li, W; Miyoshi, E; Osumi, D; Takahashi, M; Taniguchi, N; Yokoe, S1
Coleman, PS; Lavietes, BB1
Berezov, TT1
Arkin, H; Holland, JF; Ohnuma, T1
Riley, V1
Riley, V; Spackman, DH1
Buckhaults, P; Chen, L; Fregien, N; Pierce, M1
Dorr, RT; Fanta, P; Hersh, EM; Salmon, SE; Taylor, CW1
Doi, H; Komatsu, H; Nishihira, T; Satomi, S1
Borella, LD; Camitta, BM; Holcenberg, JS; Ring, BJ1
Qian, JK; Wang, BZ; Wen, XL; Yang, GH; Zhang, RJ1
Dennis, JW; Laferté, S; Vanderelst, I1
Hersh, EM1
Canellos, GP; Cooney, DA; Hardesty, CT; Haskell, CM1
Daill, M; Fink, E; Kronberger, L; Schindler, R1
Oettgen, HF1
Cooney, DA; Handschumacher, RE1
Hayaishi, O; Honjo, T1
Jacobasch, KH1
Freeman, A; Holland, JF; Ohnuma, T; Sinks, LF1
Hersh, EM; Ohno, R1
Chaudhuri, TK; Winchell, HS1
Boyse, EA; Brodey, RS; Campbell, HA; Fidler, J; Old, LJ; Teller, JD1
Balis, ME; Krakoff, IH; Miller, HK; Salser, JS1
Balis, ME; Miller, HK; Salser, JS1
Menkès, G1

Reviews

19 review(s) available for asparagine and Neoplasms

ArticleYear
Targeting amino acid metabolism in cancer.
    International review of cell and molecular biology, 2022, Volume: 373

    Topics: Amino Acids; Arginine; Asparagine; Cysteine; Humans; Methionine; Neoplasms

2022
Overview of the Properties of Glutamic Peptidases That Are Present in Plant and Bacterial Pathogens and Play a Role in Celiac Disease and Cancer.
    Biochemistry, 2023, 02-07, Volume: 62, Issue:3

    Topics: Asparagine; Bacteria; Celiac Disease; Glutamic Acid; Histidine; Humans; Neoplasms; Peptide Hydrolases

2023
Oligosaccharyltransferase: A Gatekeeper of Health and Tumor Progression.
    International journal of molecular sciences, 2019, Dec-02, Volume: 20, Issue:23

    Topics: Amino Acid Sequence; Asparagine; Disease Progression; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Glycosylation; Hexosyltransferases; Humans; Membrane Proteins; Neoplasms; Polysaccharides; Protein Processing, Post-Translational

2019
CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.
    Pathogens and disease, 2018, 07-01, Volume: 76, Issue:5

    Topics: Amidohydrolases; Asparagine; Bacterial Toxins; Computational Biology; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli Proteins; Glutamine; Immunologic Factors; Neoplasms; rac1 GTP-Binding Protein; Virulence Factors

2018
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.
    Current drug targets, 2019, Volume: 20, Issue:7

    Topics: Asparagine; Binding Sites; Cellular Senescence; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Humans; Leucine; Models, Molecular; Neoplasms; Protein Kinase Inhibitors

2019
Fuelling cancer cells.
    Nature reviews. Endocrinology, 2019, Volume: 15, Issue:2

    Topics: Asparagine; Aspartic Acid; Disease Progression; Female; Humans; Lactic Acid; Male; Neoplasms; Oxygen Consumption; Proteins; Reference Values; Tumor Cells, Cultured; Tumor Microenvironment

2019
Asparagine synthetase: regulation by cell stress and involvement in tumor biology.
    American journal of physiology. Endocrinology and metabolism, 2013, Apr-15, Volume: 304, Issue:8

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Stress, Physiological; Unfolded Protein Response

2013
ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.
    Amino acids, 2016, Volume: 48, Issue:1

    Topics: Amidohydrolases; Animals; Asparagine; Glutamine; Humans; Hyperammonemia; Neoplasms; Nitrogen; Sulfur

2016
Expanding targets for a metabolic therapy of cancer: L-asparaginase.
    Recent patents on anti-cancer drug discovery, 2012, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Drug Delivery Systems; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Chemistry, biochemistry, and safety of acrylamide. A review.
    Journal of agricultural and food chemistry, 2003, Jul-30, Volume: 51, Issue:16

    Topics: Acrylamide; Acrylic Resins; Alkylation; Animals; Asparagine; Environmental Exposure; Food Analysis; Food Handling; Humans; Maillard Reaction; Neoplasms; Nervous System; Reproduction; Risk Factors

2003
Chemotherapy-induced hypersensitivity reactions.
    Oncology nursing forum, 2005, Sep-01, Volume: 32, Issue:5

    Topics: Antineoplastic Agents; Asparagine; Drug Hypersensitivity; Humans; Neoplasms; Oncology Nursing; Platinum Compounds; Podophyllotoxin; Risk Assessment; Risk Factors; Taxoids

2005
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
    CRC critical reviews in biochemistry, 1981, Volume: 11, Issue:4

    Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Membrane Permeability; Cholesterol; Citric Acid Cycle; Electron Spin Resonance Spectroscopy; Glucose; Glutamates; Glutamic Acid; Glutamine; Lipid Bilayers; Liver Neoplasms, Experimental; Membrane Lipids; Mitochondria; Mitochondria, Liver; Models, Biological; Neoplasms; Oxygen Consumption; Phenotype; Purines; Pyrimidines; Pyruvates; Pyruvic Acid; Surface Properties

1981
[Asparagine biosynthesis and tumor growth].
    Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:3

    Topics: Adenosine Triphosphate; Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Glutamine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Liver Neoplasms, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Rats; Transaminases

1982
Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide beta(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential.
    Glycoconjugate journal, 1997, Volume: 14, Issue:5

    Topics: Animals; Asparagine; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Gene Expression Regulation, Enzymologic; Humans; N-Acetylglucosaminyltransferases; Neoplasm Metastasis; Neoplasms; Oligosaccharides; Signal Transduction

1997
[Anti-cancer therapy with amino acid imbalance].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 5

    Topics: Amino Acids; Antimetabolites, Antineoplastic; Arginine; Asparagine; Glutamine; Humans; Isoxazoles; Methionine; Neoplasms; Valine

2001
[L-asparaginase: A new principle in the chemotherapy of malignant neoplasms].
    Blut, 1969, Volume: 19, Issue:6

    Topics: Animals; Antibodies; Asparaginase; Asparagine; Bone Marrow; Escherichia coli; Guinea Pigs; Humans; Leukemia, Lymphoid; Mice; Neoplasms; Serratia marcescens

1969
L-asparaginase and L-asparagine metabolism.
    Annual review of pharmacology, 1970, Volume: 10

    Topics: Animals; Asparaginase; Asparagine; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Humans; Mice; Neoplasms; Rats

1970
[Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1970, Volume: 15, Issue:5

    Topics: Animals; Asparaginase; Asparagine; Escherichia coli; Guinea Pigs; Humans; Leukemia; Mutation; Neoplasms; Neoplasms, Experimental

1970
[Enzyme therapy of malignant tumors].
    Archiv fur Geschwulstforschung, 1969, Volume: 34, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Glutaminase; Guinea Pigs; Humans; Leukemia; Mice; Neoplasms; Neoplasms, Experimental; Rabbits; Rats

1969

Trials

2 trial(s) available for asparagine and Neoplasms

ArticleYear
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:1

    Topics: Adult; Antineoplastic Agents; Asparaginase; Asparagine; Carcinoma, Non-Small-Cell Lung; Drug Screening Assays, Antitumor; Glutaminase; Humans; Lung Neoplasms; Melanoma; Neoplasm Proteins; Neoplasms; Polyethylene Glycols; Skin Neoplasms

2001
Phase I study of succinylated acinetobacter L-glutaminase-L-asparaginase.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Acinetobacter; Adolescent; Alkalosis, Respiratory; Amidohydrolases; Asparagine; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Female; Glutamine; Humans; Hyperglycemia; Leukemia, Lymphoid; Male; Neoplasms

1979

Other Studies

48 other study(ies) available for asparagine and Neoplasms

ArticleYear
Asparagine bioavailability regulates the translation of MYC oncogene.
    Oncogene, 2022, Volume: 41, Issue:44

    Topics: 3' Untranslated Regions; Amino Acids; Animals; Asparagine; Biological Availability; Genes, myc; Mice; Neoplasms; Proto-Oncogene Proteins c-myc

2022
Asparagine restriction enhances CD8
    Nature metabolism, 2023, Volume: 5, Issue:8

    Topics: Animals; Asparagine; CD8-Positive T-Lymphocytes; Glucose; Neoplasms; NF-E2-Related Factor 2

2023
GSK3α Regulates Temporally Dynamic Changes in Ribosomal Proteins upon Amino Acid Starvation in Cancer Cells.
    International journal of molecular sciences, 2023, Aug-26, Volume: 24, Issue:17

    Topics: Amino Acids; Asparagine; Glycogen Synthase Kinase 3; Humans; Neoplasms; Protein Serine-Threonine Kinases; Ribosomal Proteins

2023
Sleeping Beauty Transposon-Mediated Asparaginase Gene Delivery by a Nanoparticle Platform.
    Scientific reports, 2019, 08-07, Volume: 9, Issue:1

    Topics: A549 Cells; Antineoplastic Agents; Asparaginase; Asparagine; Cell Survival; Cisplatin; Combined Modality Therapy; DNA Transposable Elements; Doxorubicin; Drug Carriers; Gene Transfer Techniques; Genetic Therapy; Humans; Nanoparticles; Neoplasms; Plasmids; Silicon Dioxide; Transfection; Transposases

2019
Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation.
    Communications biology, 2019, Volume: 2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Affinity; Antigen-Antibody Complex; Antineoplastic Agents, Immunological; Asparagine; B7-H1 Antigen; Binding, Competitive; Crystallography, X-Ray; Epitopes; Female; Glycosylation; Humans; Mice; Mice, Inbred C57BL; Models, Molecular; Neoplasms; Nivolumab; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Protein Interaction Domains and Motifs

2019
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
    Cell metabolism, 2021, 05-04, Volume: 33, Issue:5

    Topics: Activating Transcription Factor 4; Animals; Asparagine; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Diet; Electron Transport Chain Complex Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred NOD; Mitochondria; Neoplasms; Nucleotides; Survival Rate

2021
Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach.
    Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:18

    Topics: Asparagine; Child; Chloroquine; Fatty Acids; Humans; Hydroxychloroquine; Membrane Proteins; Neoplasms; Neuronal Ceroid-Lipofuscinoses; Palmitates; Thiolester Hydrolases

2022
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
    mBio, 2017, 08-15, Volume: 8, Issue:4

    Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides

2017
The landscape of cancer cell line metabolism.
    Nature medicine, 2019, Volume: 25, Issue:5

    Topics: Animals; Asparaginase; Asparagine; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cell Line, Tumor; DNA Methylation; Female; Gene Knockdown Techniques; Humans; Kynurenine; Liver Neoplasms; Metabolome; Mice; Mice, Nude; Neoplasms; Stomach Neoplasms

2019
In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers.
    BioMed research international, 2014, Volume: 2014

    Topics: Asparagine; Binding Sites; Carrier Proteins; Chemistry, Pharmaceutical; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Hydrogen Bonding; Ligands; Lysine; Medicine, Chinese Traditional; Membrane Proteins; Mitosis; Molecular Dynamics Simulation; Neoplasms; Protein Conformation; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Tryptophan

2014
In silico investigation of potential TRAF6 inhibitor from traditional Chinese medicine against cancers.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Asparagine; Cattle; Crystallography, X-Ray; Diiodotyrosine; Humans; Hydrogen Bonding; Hypoxia-Inducible Factor 1, alpha Subunit; Ligands; Medicine, Chinese Traditional; Molecular Dynamics Simulation; Neoplasms; Neovascularization, Pathologic; Protein Binding; Protein Structure, Secondary; TNF Receptor-Associated Factor 6; Tryptophan

2014
Asparagine protects tumor cells from glutamine depletion-induced cell death.
    Cancer discovery, 2014, Volume: 4, Issue:11

    Topics: Asparagine; Aspartate-Ammonia Ligase; Cell Death; Glutamine; Humans; Neoplasms; Transcription Factor CHOP

2014
Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Animals; Asparagine; Brefeldin A; Cell Line, Tumor; Cell Movement; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Humans; Mice; Monensin; Neoplasm Invasiveness; Neoplasms; NIH 3T3 Cells; Point Mutation; Protein Processing, Post-Translational; Protein Transport; Ribosomal Proteins; Transfection; Tunicamycin

2016
Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM.
    Frontiers in bioscience : a journal and virtual library, 2008, May-01, Volume: 13

    Topics: 3T3 Cells; Animals; Antigens, Neoplasm; Asparagine; Cell Adhesion Molecules; Cell Line; Epithelial Cell Adhesion Molecule; Glycoside Hydrolases; Glycosylation; Humans; Kidney; Mice; Mutation; Neoplasms

2008
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
    ACS chemical biology, 2010, Feb-19, Volume: 5, Issue:2

    Topics: Animals; Asparagine; Carbocyanines; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epoxy Compounds; Fluorescent Dyes; Humans; Mice; Mice, Inbred Strains; Neoplasms; NIH 3T3 Cells; Spectroscopy, Near-Infrared; Xenograft Model Antitumor Assays

2010
Desamidation of glutamine and asparagine in normal and neoplastic hepatic tissues.
    Journal of the National Cancer Institute, 1947, Volume: 7, Issue:4

    Topics: Amino Acids; Asparagine; Glutamine; Liver Neoplasms; Neoplasms

1947
Cancer. DNA damage, deamidation, and death.
    Science (New York, N.Y.), 2002, Nov-15, Volume: 298, Issue:5597

    Topics: Antineoplastic Agents; Apoptosis; Asparagine; Aspartic Acid; bcl-X Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA, Neoplasm; Genes, p53; Genes, Retinoblastoma; Humans; Models, Biological; Mutation; Neoplasms; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Tumor Suppressor Protein p53

2002
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Camptothecin; COS Cells; Exons; Genetic Variation; Glucuronates; Glucuronic Acid; Glucuronosyltransferase; Humans; Irinotecan; Japan; Mutation; Neoplasms; Polymorphism, Single Nucleotide; Transfection; UDP-Glucuronosyltransferase 1A9

2003
Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine.
    Science (New York, N.Y.), 1956, Jul-20, Volume: 124, Issue:3212

    Topics: Animals; Asparagine; Biochemical Phenomena; Carcinoma 256, Walker; Glutamine; Humans; In Vitro Techniques; Neoplasms

1956
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
    Analytical biochemistry, 1963, Volume: 6

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; Malates; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Proteins; Research; Sarcoma; Sarcoma, Experimental

1963
A TRANSPORT SYSTEM SERVING FOR MONO- AND DIAMINO ACIDS.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51

    Topics: Amino Acids; Aminobutyrates; Aminoisobutyric Acids; Arginine; Asparagine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Glutamine; Glycine; Leucine; Lysine; Neoplasms; Ornithine; Phenylalanine; Proteins; Research

1964
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
    The Nebraska state medical journal, 1964, Volume: 49

    Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine

1964
QUANTITATIVE COLONIAL GROWTH OF MAMMALIAN CELLS IN FIBRIN CELLS.
    Experimental cell research, 1964, Volume: 34

    Topics: Asparagine; Fibrin; Folic Acid; Immune Sera; Mast Cells; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Serine; Thrombin; Tissue Culture Techniques

1964
TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI.
    Archives of biochemistry and biophysics, 1964, Volume: 105

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacillus; Electrophoresis; Escherichia coli; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma; Sarcoma, Experimental

1964
IN VITRO EFFECTS OF GUINEA PIG SERUM ON THE JENSEN, JA-1 AND JA-2 SARCOMAS.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119

    Topics: Amidohydrolases; Animals; Asparagine; Blood; Culture Media; Guinea Pigs; In Vitro Techniques; Metabolism; Neoplasms; Pharmacology; Research; Research Design; Sarcoma; Sarcoma, Experimental; Tissue Culture Techniques

1965
[EXPERIMENTAL STUDIES AND CLINICAL USE OF ELECTROLYTE-CARRIER COMPOUNDS. 6. ORIENTATIONAL RESEARCH ON MAGNESIUM- AND POTASSIUM-NICOTINYL-ASPARAGINATE (MG + K - NA)].
    Arztliche Forschung, 1964, Nov-10, Volume: 18

    Topics: Asparagine; Biomedical Research; Drug Therapy; Electrolytes; Fatigue; Magnesium; Neoplasms; Pharmacology; Potassium; Rats; Research; Toxicology

1964
[Experimental principles and clinical use of electrolyte carrier compounds. 4. The normalizing effect of potassium and magnesium asparaginate on an atypical substrate balance appearing in cancer patients. The importance of the problem for the host organis
    Arztliche Forschung, 1961, Nov-10, Volume: 15

    Topics: Asparagine; Electrolytes; Humans; Magnesium; Neoplasms; Potassium

1961
Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD.
    Journal of molecular biology, 2003, Oct-03, Volume: 332, Issue:5

    Topics: Amino Acid Motifs; Amino Acid Sequence; Angiogenesis Inhibitors; Antineoplastic Agents; Asparagine; Aspartic Acid; Blood Platelets; Cell Adhesion; Crystallography, X-Ray; Disintegrins; Integrin alphaVbeta3; Integrins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Neoplasms; Oligopeptides; Platelet Aggregation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Snake Venoms; Tryptophan

2003
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:5

    Topics: Animals; Antigen Presentation; Asparagine; Autoantigens; CD8-Positive T-Lymphocytes; Epitopes; Female; Mice; Mice, Inbred C57BL; Models, Biological; Neoplasms; Oxidoreductases; T-Lymphocytes

2006
Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
    Oncogene, 2007, Sep-20, Volume: 26, Issue:43

    Topics: Adenomatous Polyposis Coli Protein; Animals; Asparagine; Disease Progression; Exodeoxyribonucleases; Flap Endonucleases; Genes, APC; Mice; Mice, Transgenic; Mutation; Neoplasms; Survival Rate

2007
N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.
    Biochimica et biophysica acta, 2008, Volume: 1780, Issue:3

    Topics: Animals; Asparagine; Cricetinae; Cricetulus; Dimerization; Humans; Mice; Models, Biological; Mutant Proteins; Neoplasms; Polysaccharides; Protein Structure, Tertiary; Receptor, ErbB-3; Sequence Deletion

2008
Differences in chemotherapeutic susceptibility of human T-, B-, and non-T-/non-B-lymphocytes in culture.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 75

    Topics: Asparaginase; Asparagine; B-Lymphocytes; Cell Line; Cytarabine; Dose-Response Relationship, Drug; Fluorouracil; Humans; Lymphocytes; Neoplasms; T-Lymphocytes

1980
Hemodialysis of amino acids: basic studies in vitro.
    Nutrition and cancer, 1981, Volume: 2, Issue:3

    Topics: Amino Acids; Asparagine; Dialysis; Humans; In Vitro Techniques; Kidneys, Artificial; Molecular Weight; Neoplasms; Renal Dialysis; Time Factors; Ultrafiltration; Urea

1981
Theoretical and practical considerations in the use of hemodialysis for the therapeutic removal of asparagine and other amino acids.
    Nutrition and cancer, 1981, Volume: 2, Issue:3

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Dose-Response Relationship, Drug; Female; Humans; Kidneys, Artificial; Lactate dehydrogenase-elevating virus; Mice; Microchemistry; Neoplasms; Renal Dialysis

1981
Medicinal protection with Chinese herb-compound against radiation damage.
    Aviation, space, and environmental medicine, 1990, Volume: 61, Issue:8

    Topics: Animals; Asparagine; Drugs, Chinese Herbal; Glucosides; Hemostatics; Humans; Incidence; Leukopenia; Mice; Neoplasms; Phenylpropionates; Radiation Injuries, Experimental; Radiotherapy; Sitosterols

1990
Asparagine-linked oligosaccharides in malignant tumour growth.
    Biochemical Society transactions, 1989, Volume: 17, Issue:1

    Topics: Animals; Asparagine; Cell Adhesion; Cell Division; Cell Line; Extracellular Matrix; Humans; Neoplasm Metastasis; Neoplasms; Oligosaccharides; Tumor Cells, Cultured

1989
Immunosuppressive enzymes.
    Transplantation proceedings, 1973, Volume: 5, Issue:3

    Topics: Animals; Antigens; Asparaginase; Asparagine; Encephalomyelitis, Autoimmune, Experimental; Erythrocytes; Glutamine; Graft vs Host Reaction; Hemocyanins; Hemolytic Plaque Technique; Humans; Hypersensitivity, Delayed; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Mice; Mitogens; Neoplasms; Sheep; Skin Tests; Skin Transplantation; Transplantation Immunology; Transplantation, Homologous

1973
Pharmacologic studies in man with crystallized L-asparaginase (NSC-109229).
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:5

    Topics: Amidohydrolases; Asparaginase; Asparagine; Crystallization; Escherichia coli; Humans; Hydrolysis; Kinetics; Neoplasms; Time Factors

1972
[Urinary excretion of asparagne and aspartate in control subjects and patients with cancer before and after treatment with K-Mg-aspartate].
    Wiener klinische Wochenschrift, 1972, Nov-10, Volume: 84, Issue:45

    Topics: Adolescent; Adult; Aged; Asparagine; Aspartic Acid; Breast Neoplasms; Cholecystitis; Female; Humans; Magnesium; Male; Middle Aged; Neoplasms; Potassium; Stomach Neoplasms

1972
[Molecular and cellular bases of cytostatic therapy].
    Schweizerische medizinische Wochenschrift, 1974, Feb-23, Volume: 104, Issue:8

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Asparaginase; Asparagine; Cell Division; Cell Line; Cells; DNA; DNA, Neoplasm; Humans; Methotrexate; Neoplasms; Nitrogen; Protein Biosynthesis; RNA; RNA, Neoplasm

1974
Biochemical and pharmacological studies with asparaginase in man.
    Cancer research, 1970, Volume: 30, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colonic Neoplasms; Escherichia coli; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Melanoma; Metabolic Clearance Rate; Middle Aged; Multiple Myeloma; Neoplasms; Neuroblastoma; Osteosarcoma

1970
[To what extent L-asparaginase affects the tumor cells? Press information of the Sektion Onkologie der Paul-Ehrlich-Gesellschaft für Chemotherapie].
    Munchener medizinische Wochenschrift (1950), 1969, Sep-12, Volume: 111, Issue:37

    Topics: Adult; Age Factors; Antineoplastic Agents; Asparaginase; Asparagine; Child; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Neoplasms

1969
Immunosuppressive effects of L-asparaginase.
    Cancer research, 1970, Volume: 30, Issue:6

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Alanine; Antibody Formation; Antigens; Asparaginase; Asparagine; Breast Neoplasms; Carcinoma; Child, Preschool; Female; Glutamates; Hemocyanins; Humans; Hypersensitivity, Delayed; Immunoglobulins; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Lysine; Male; Middle Aged; Neoplasms; Osteosarcoma; Tyrosine

1970
Diminished oxidation of 14C-UL-L-asparagine to 14CO2 in mice and humans with tumors: a possible means for assessing efficacy of therapy?
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1970, Volume: 11, Issue:10

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Humans; Injections, Intravenous; Leukemia, Lymphoid; Male; Mice; Multiple Myeloma; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction

1970
Treatment of lymphosarcoma in the dog with L-asparaginase.
    Cancer, 1967, Volume: 20, Issue:7

    Topics: Amidohydrolases; Animals; Asparagine; Dogs; Escherichia coli; Guinea Pigs; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Ouabain

1967
Sensitivity to L-asparaginase and amino acid metabolism.
    Journal of the National Cancer Institute, 1970, Volume: 44, Issue:5

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Carbon Isotopes; Carcinoma 256, Walker; Citrulline; Culture Techniques; Female; Formates; Glutamine; Half-Life; Humans; Leukemia; Leukemia, Experimental; Male; Mice; Neoplasms; Rats; Spleen; Thymidine; Time Factors; Tritium

1970
Amino acid levels following L-asparagine amidohydrolase (EC.3.5.1.1) therapy.
    Cancer research, 1969, Volume: 29, Issue:1

    Topics: Amidohydrolases; Amino Acids; Asparaginase; Asparagine; Female; Glutamates; Glutamine; Humans; Male; Neoplasms

1969
[The "reequilibration" test and its use in the treatment of certain forms of cancer and other afflictions].
    Journal of chromatography, 1966, Volume: 25, Issue:1

    Topics: Adenosine Triphosphate; Asparagine; Betaine; Choline; Creatine; Cysteine; Deficiency Diseases; Electrophoresis; Elements; Glutamates; Histidine; Humans; Metabolic Diseases; Methionine; Neoplasms; Quaternary Ammonium Compounds

1966