asparagine and Experimental Neoplasms

asparagine has been researched along with Experimental Neoplasms in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-199064 (96.97)18.7374
1990's1 (1.52)18.2507
2000's1 (1.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abeles, RH; Foxman, BM; Stern, AM; Tashjian, AH1
BROOME, JD5
MCCOY, TA; ORR, GR; PATTERSON, MK1
LORINCZ, AB; RYAN, WL1
SCHINDLER, R1
MASHBURN, LT; WRISTON, JC1
Aldrich, CJ; Anthony, TG; Bunpo, P; Durden, DL; Goodwin, LO; McNurlan, MA; Mileva, I; Oberle, LM; Reinert, RB; Wang, XP; Wek, RC; Wek, SA1
Borella, L; Hiramoto, R; Journey, LJ1
Berezov, TT1
Dennis, JW; Schirrmacher, V; Waller, CA1
Chen, KY1
Logue, LW; Mokotoff, M1
Anderson, DR; Grimes, WJ1
Edman, P; Sjöholm, I1
Gabel, CA; Kornfeld, S1
Hageman, JJ; Koomen, GJ; Pandit, UK; Wanner, MJ1
Coleman, PS; Lavietes, BB1
Chakrabarty, SL; Manna, S; Sadhukhan, R; Sinha, A1
Banks, GT; Bascomb, S; Bettelheim, KA; Fleming, A; Skarstedt, MT1
Cooney, DA; Homan, ER; Jayaram, HN; Milman, HA; Rosenbluth, RJ1
Brynes, S; Burckart, GJ; Mokotoff, M1
Davidson, L; Kitto, GB; Mason, M; Smith, G; Thiet, TQ1
Davies, MR; Lambert, LP; Marshall, RD1
Bagaglio, JF; Mokotoff, M; Parikh, BS1
Bagaglio, JF; Brynes, S; Mokotoff, M1
Korus, RA; O'Driscoll, KF; Ohnuma, T; Walczack, IM1
Abuchowski, A; Davis, FF; McCoy, JR; Palczuk, NC; van Es, T1
Chlopkiewicz, B; Koziorowska, J1
Breitman, ML; Dennis, JW; Kerbel, RS; Laferté, S; Waghorne, C1
Arumugham, RG; Hsieh, TC; Laine, RA; Tanzer, ML1
Carver, JP; Dell, A; Dennis, JW; Fukuda, M; Laferté, S1
Alpar, HO; Lewis, DA1
Cooney, D; Hersh, LS; Murphy, GP; Sampson, D1
Cooney, DA; Milman, HA1
Orr, GR; Patterson, MK1
Baliga, BS; Borek, E; Srinivasan, PR; Weinstein, IB1
Abbondanza, A; Bonetti, E; Della Corte, E; Stirpe, F1
Knox, WE; Kupchik, HZ1
Grunberger, D; Morris, HP; Srinivasan, D; Srinivasan, PR; Weinstein, IB1
Chou, TC; Handschumacher, RE1
Summers, WP1
Ryan, WL; Sornson, HC1
Chang, PK; Handschumacher, RE; Sciarini, LJ1
Murthy, MR; Roux, H; Thenot, JP1
Chang, TM1
Cameron, T; Cooney, DA; Homan, E; Schaeppi, U1
Cook, MM; Hilleman, MR; Larson, VM; Shen, TY; Tytell, AA; Wagner, AF1
Bachynsky, N; Prager, MD1
Hayaishi, O; Honjo, T1
Jacobasch, KH1
Dworak, JE; Ryan, WL1
Boyd, JW; Phillips, AW1
Grossowicz, N; Lichtenstein, N; Schlesinger, M1
Chaudhuri, TK; Winchell, HS1
Broome, JD; Reeves, JY; Schwartz, JH1
Dixon, RL; Lee, IP; Woods, JS1
Capizzi, RL; Cooney, DA; Handschumacher, RE1
Gordon, CS; Mashburn, LT1
Dixon, RL; Woods, JS1
Kidd, JG; Sobin, LH1
Wriston, JC; Yellin, TO1
Hempel, K; Männl, HF1

Reviews

4 review(s) available for asparagine and Experimental Neoplasms

ArticleYear
[Asparagine biosynthesis and tumor growth].
    Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:3

    Topics: Adenosine Triphosphate; Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Glutamine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Liver Neoplasms, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Rats; Transaminases

1982
Immobilization of enzymes, adsorbents, or both within semipermeable microcapsules (artificial cells) for clinical and experimental treatment of metabolite-related disorders.
    Birth defects original article series, 1973, Volume: 9, Issue:2

    Topics: Acatalasia; Administration, Oral; Animals; Asparaginase; Asparagine; Catalase; Disease Models, Animal; Enzymes; Injections, Intraperitoneal; Kidney Failure, Chronic; Kidneys, Artificial; Lymphoma, Non-Hodgkin; Membranes, Artificial; Metabolic Diseases; Mice; Neoplasms, Experimental; Permeability; Pharmaceutic Aids; Sarcoma, Experimental; Solubility; Urea; Urease; Uremia

1973
[Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1970, Volume: 15, Issue:5

    Topics: Animals; Asparaginase; Asparagine; Escherichia coli; Guinea Pigs; Humans; Leukemia; Mutation; Neoplasms; Neoplasms, Experimental

1970
[Enzyme therapy of malignant tumors].
    Archiv fur Geschwulstforschung, 1969, Volume: 34, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Glutaminase; Guinea Pigs; Humans; Leukemia; Mice; Neoplasms; Neoplasms, Experimental; Rabbits; Rats

1969

Other Studies

62 other study(ies) available for asparagine and Experimental Neoplasms

ArticleYear
DL-threo-beta-Fluoroaspartate and DL-threo-beta-fluoroasparagine: selective cytotoxic agents for mammalian cells in culture.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:5

    Topics: Amino Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Cells, Cultured; Models, Molecular; Neoplasms, Experimental; Rats; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction

1982
Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. II. Lymphoma 6C3HED cells cultured in a medium devoid of L-asparagine lose their susceptibility to the effects of guinea pig serum in vivo.
    The Journal of experimental medicine, 1963, Volume: 118

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Complement System Proteins; Disease Susceptibility; Endopeptidases; Guinea Pigs; Lymphocyte Count; Lymphoma; Mice; Neoplasms, Experimental; Pyrimidines

1963
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
    Analytical biochemistry, 1963, Volume: 6

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; Malates; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Proteins; Research; Sarcoma; Sarcoma, Experimental

1963
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
    The Nebraska state medical journal, 1964, Volume: 49

    Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine

1964
QUANTITATIVE COLONIAL GROWTH OF MAMMALIAN CELLS IN FIBRIN CELLS.
    Experimental cell research, 1964, Volume: 34

    Topics: Asparagine; Fibrin; Folic Acid; Immune Sera; Mast Cells; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Serine; Thrombin; Tissue Culture Techniques

1964
TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI.
    Archives of biochemistry and biophysics, 1964, Volume: 105

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacillus; Electrophoresis; Escherichia coli; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma; Sarcoma, Experimental

1964
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
    The Journal of biological chemistry, 2006, Oct-20, Volume: 281, Issue:42

    Topics: Animals; Asparaginase; Asparagine; Escherichia coli; Female; Glutamine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Protein Serine-Threonine Kinases; Wolinella

2006
In vivo and in vitro effects of the L-asparaginase fraction of guinea pig serum on the 6C3HED ascites lymphosarcoma.
    Cancer research, 1966, Volume: 26, Issue:12

    Topics: Aminohydrolases; Animals; Antineoplastic Agents; Asparagine; Carcinoma, Ehrlich Tumor; Guinea Pigs; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Microscopy, Electron; Microscopy, Fluorescence; Neoplasms, Experimental; Nucleosides; Spleen; Tritium

1966
Identification of asparagine-linked oligosaccharides involved in tumor cell adhesion to laminin and type IV collagen.
    The Journal of cell biology, 1984, Volume: 99, Issue:4 Pt 1

    Topics: Animals; Asparagine; Carbohydrate Conformation; Carbohydrate Sequence; Cell Adhesion; Cell Line; Collagen; Laminin; Lectins; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Oligosaccharides; Receptors, Collagen; Receptors, Immunologic; Receptors, Laminin

1984
Differences in the mode of regulation of ornithine decarboxylase activity in undifferentiated versus differentiated mouse N-18 neuroblastoma cells.
    FEBS letters, 1980, Oct-06, Volume: 119, Issue:2

    Topics: Animals; Asparagine; Bucladesine; Carboxy-Lyases; Cell Differentiation; Cell Line; Culture Media; Enzyme Induction; Mice; Neoplasms, Experimental; Neuroblastoma; Neurons; Ornithine Decarboxylase

1980
Potential inhibitors of L-asparagine biosynthesis. 5. Electrophilic amide analogues of (S)-2,3-diaminopropionic acid.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:5

    Topics: Alanine; Amides; Animals; Asparagine; beta-Alanine; Cells, Cultured; Chemical Phenomena; Chemistry; Depression, Chemical; Neoplasms, Experimental; Rats

1981
Heterogeneity of asparagine-linked oligosaccharides of five glycosylation sites on immunoglobulin M heavy chain from mineral oil plasmacytoma 104E.
    The Journal of biological chemistry, 1982, Dec-25, Volume: 257, Issue:24

    Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Carbohydrates; Cell Line; Glycopeptides; Humans; Immunoglobulin Heavy Chains; Immunoglobulin M; Mice; Mineral Oil; Neoplasms, Experimental; Oligosaccharides; Plasmacytoma; Species Specificity

1982
Acrylic microspheres in vivo VI: antitumor effect of microparticles with immobilized L-asparaginase against 6C3HED lymphoma.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:6

    Topics: Acrylates; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Enzymes, Immobilized; Lymphoma; Mice; Microspheres; Neoplasms, Experimental; Time Factors

1983
L-Asparaginase: discovery and development as a tumor-inhibitory agent.
    Cancer treatment reports, 1981, Volume: 65 Suppl 4

    Topics: Animals; Asparaginase; Asparagine; Cell Line; Escherichia coli; Guinea Pigs; Half-Life; History, 20th Century; Humans; Leukemia; Lymphoma; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Sarcoma, Experimental

1981
Lysosomal enzyme phosphorylation in mouse lymphoma cell lines with altered asparagine-linked oligosaccharides.
    The Journal of biological chemistry, 1982, Sep-25, Volume: 257, Issue:18

    Topics: Animals; Asparagine; Glycoside Hydrolases; Hydrolases; Lymphoma; Lysosomes; Mannosephosphates; Mice; Mutation; Neoplasms, Experimental; Oligosaccharides; Phosphorylation

1982
Potential carcinostatics. 4. Synthesis and biological properties of erythro- and threo-beta-fluoroaspartic acid and erythro-beta-fluoroasparagine.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:1

    Topics: Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Female; Leukemia L5178; Lung Neoplasms; Male; Mice; Models, Molecular; Molecular Conformation; Neoplasms, Experimental

1980
The role of lipid metabolism in neoplastic differentiation.
    Journal of theoretical biology, 1980, Aug-07, Volume: 85, Issue:3

    Topics: Animals; Asparagine; Cell Transformation, Neoplastic; Cholesterol; Citric Acid Cycle; Feedback; Glucose; Glutamine; Humans; Lipids; Models, Biological; Neoplasms, Experimental; Nitrogen; Oxygen Consumption; Polyamines

1980
Purification, characterization and antitumor activity of L-asparaginase isolated from Pseudomonas stutzeri MB-405.
    Current microbiology, 1995, Volume: 30, Issue:5

    Topics: Amino Acids; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Isoelectric Point; Kinetics; Male; Metals; Mice; Molecular Weight; Neoplasms, Experimental; Pseudomonas; Substrate Specificity

1995
The properties and large-scale production of L-asparaginase from citrobacter.
    Journal of general microbiology, 1975, Volume: 91, Issue:1

    Topics: Animals; Asparaginase; Asparagine; Citrobacter; Culture Media; Drug Evaluation, Preclinical; Enterobacteriaceae; Fermentation; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Lymphoma, Non-Hodgkin; Mice; Molecular Weight; Neoplasms, Experimental; Oxygen; Stereoisomerism; Temperature; Zea mays

1975
DON, CONV and DONV-II. Inhibition of L-'asparagine synthetase in vivo.
    Biochemical pharmacology, 1976, Aug-15, Volume: 25, Issue:16

    Topics: Amino Acids; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Azo Compounds; Cells, Cultured; Diazooxonorleucine; DNA; Formates; Glutamine; Levulinic Acids; Ligases; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pancreas

1976
Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogues of L-asparagine.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Carcinoma, Hepatocellular; Hydrazines; In Vitro Techniques; Leukemia, Experimental; Ligases; Liver Neoplasms; Mice; Neoplasms, Experimental; Rats; Structure-Activity Relationship; Sulfonamides

1978
Tumor inhibitory and non-tumor inhibitory L-asparaginases from Pseudomonas geniculata.
    Journal of bacteriology, 1979, Volume: 137, Issue:1

    Topics: Animals; Antigens, Bacterial; Asparaginase; Asparagine; Cross Reactions; Glutamine; Hydrogen-Ion Concentration; Mice; Molecular Weight; Neoplasms, Experimental; Pseudomonas; Substrate Specificity

1979
L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED.
    Clinical science (London, England : 1979), 1979, Volume: 56, Issue:6

    Topics: Amino Acyl-tRNA Synthetases; Animals; Antineoplastic Agents; Ascitic Fluid; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Transformation, Neoplastic; Cells, Cultured; Horses; Ligases; Lymphoma; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Time Factors

1979
Potential inhibitors of L-asparagine biosynthesis. 2. Chemistry and biological activity of beta-hydroxyaspartic acid and its derivatives.
    Journal of medicinal chemistry, 1975, Volume: 18, Issue:4

    Topics: Animals; Asparagine; Aspartic Acid; Carcinoma, Hepatocellular; Depression, Chemical; Glutamine; Hydroxy Acids; Ligases; Liver Neoplasms; Male; Molecular Conformation; Neoplasms, Experimental; Rats; Stereoisomerism; Structure-Activity Relationship

1975
Potential inhibitors of L-asparagine biosynthesis. 3. Aromatic sulfonyl fluoride analogs of L-asparagine and L-glutamine.
    Journal of medicinal chemistry, 1975, Volume: 18, Issue:9

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Carcinoma, Hepatocellular; Depression, Chemical; Glutamine; Liver Neoplasms; Neoplasms, Experimental; Rats; Sarcoma, Experimental; Sulfones

1975
Gel entrapped L-asparaginase: kinetic behavior and antitumor activity.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 195, Issue:2

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Drug Stability; Escherichia coli; Gels; Hydrogen-Ion Concentration; Kinetics; Lymphoma; Mice; Neoplasms, Experimental; Particle Size

1975
Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Amidohydrolases; Animals; Antibody Formation; Asparaginase; Asparagine; Drug Therapy, Combination; Glutaminase; Glutamine; Metabolic Clearance Rate; Mice; Neoplasms, Experimental; Polyethylene Glycols

1979
Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.
    Cancer research, 1975, Volume: 35, Issue:6

    Topics: Animals; Asparaginase; Asparagine; Autoradiography; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Haplorhini; L Cells; Leukemia L1210; Methotrexate; Neoplasms, Experimental

1975
Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.
    Science (New York, N.Y.), 1987, May-01, Volume: 236, Issue:4801

    Topics: Animals; Asparagine; Carbohydrate Conformation; Cell Line; Cell Transformation, Neoplastic; Glucosyltransferases; Glycosylation; Lysosomal Membrane Proteins; Membrane Glycoproteins; Membrane Proteins; Mice; Mutation; N-Acetylglucosaminyltransferases; Neoplasm Metastasis; Neoplasms, Experimental; Oligosaccharides; Structure-Activity Relationship

1987
Structures of the asparagine-linked sugar chains of laminin.
    Biochimica et biophysica acta, 1986, Aug-06, Volume: 883, Issue:1

    Topics: Animals; Asparagine; Basement Membrane; Carbohydrate Conformation; Chromatography, Affinity; Chromatography, Gel; Galactose; Glucosamine; Glycopeptides; Laminin; Mice; Molecular Weight; Neoplasms, Experimental; Oligosaccharides

1986
Asn-linked oligosaccharides in lectin-resistant tumor-cell mutants with varying metastatic potential.
    European journal of biochemistry, 1986, Dec-01, Volume: 161, Issue:2

    Topics: Asparagine; Cell Line; Chromatography, Affinity; Chromatography, High Pressure Liquid; Concanavalin A; Lectins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Mutation; Neoplasms, Experimental; Oligosaccharides; Phenotype

1986
Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes.
    Biochemical pharmacology, 1985, Jan-15, Volume: 34, Issue:2

    Topics: Animals; Asparaginase; Asparagine; Erythrocytes; Female; Glutamine; Lymphoma; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Rats; Rats, Inbred Strains

1985
A new technique employing extracorporeal chemotherapy.
    Transactions - American Society for Artificial Internal Organs, 1972, Volume: 18, Issue:0

    Topics: Animals; Asparaginase; Asparagine; Chemotherapy, Cancer, Regional Perfusion; Dogs; Haplorhini; Immunosuppression Therapy; Lymphocytes; Methylmethacrylates; Mitogens; Neoplasms, Experimental; Papio; Thymidine; Tritium

1972
The distribution of L-asparagine synthetase in the principal organs of several mammalian and avian species.
    The Biochemical journal, 1974, Volume: 142, Issue:1

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Autoanalysis; Brain; Carbon Radioisotopes; Cats; Cattle; Chickens; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Kidney; Leukemia; Ligases; Liver; Lung; Male; Mice; Neoplasms, Experimental; Ovary; Pancreas; Rabbits; Rats; Sheep; Spleen; Swine; Temperature; Testis; Turkeys

1974
Asparagine biosynthesis by the Novikoff Hepatoma isolation, purification, property, and mechanism studies of the enzyme system.
    The Journal of biological chemistry, 1968, Jan-25, Volume: 243, Issue:2

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Ammonium Chloride; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Carcinoma, Hepatocellular; Diphosphates; Female; Glutamine; Hydrogen-Ion Concentration; Hydroxamic Acids; Hydroxylamines; Liver Neoplasms; Magnesium; Manganese; Neoplasms, Experimental; Potassium; Rats

1968
Differences in the transfer RNA's of normal liver and Novikoff hepatoma.
    Proceedings of the National Academy of Sciences of the United States of America, 1969, Volume: 62, Issue:3

    Topics: Amino Acids; Animals; Asparagine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Histidine; Ligases; Liver; Liver Neoplasms; Methods; Neoplasms, Experimental; Rats; RNA, Transfer; Tritium; Tyrosine

1969
The regulation of L-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes.
    The Biochemical journal, 1969, Volume: 115, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Asparaginase; Asparagine; Carcinoma, Hepatocellular; Castration; Diet; Dietary Proteins; Estradiol; Female; Liver; Liver Neoplasms; Liver Regeneration; Male; Mice; Neoplasms, Experimental; Rats; Sex Factors; Starvation

1969
Assays of glutamine and its aminotransferase with the enol-borate of phenylpyruvate.
    Archives of biochemistry and biophysics, 1970, Volume: 136, Issue:1

    Topics: Age Factors; Animals; Asparagine; Boric Acids; Carcinoma, Hepatocellular; Cold Temperature; Drug Stability; Female; Fetus; Glutamates; Glutamine; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver Neoplasms; Liver Regeneration; Male; Mammary Neoplasms, Experimental; Mathematics; Methods; Neoplasms, Experimental; Organ Specificity; Phenylpyruvic Acids; Rats; Sex Factors; Solubility; Spectrophotometry; Time Factors; Transaminases; Ultraviolet Rays

1970
Alterations in specific transfer ribonucleic acids in a spectrum of hepatomas.
    Biochemistry, 1971, May-25, Volume: 10, Issue:11

    Topics: Animals; Asparagine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Diploidy; Escherichia coli; Genetic Code; Hindlimb; Histidine; Ligases; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Phenylalanine; Polynucleotides; Polyploidy; Rats; Ribosomes; RNA, Transfer; Tritium; Tyrosine; Ultracentrifugation

1971
Production of L-asparagine by tumor cells and the effect of asparagine analogs.
    Biochemical pharmacology, 1972, Volume: 21, Issue:1

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Azo Compounds; Bromine; Carbon Isotopes; Carcinoma, Hepatocellular; Chlorine; Glutamine; Kinetics; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Mast Cells; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma 180

1972
Chemically induced mutation of L-5178Y mouse leukemia cells from asparagine-dependence to asparagine-independence.
    Mutation research, 1973, Volume: 20, Issue:3

    Topics: Acridines; Animals; Asparagine; Cell Division; Cell Line; Cell Survival; Clone Cells; Gene Frequency; Leukemia, Lymphoid; Mesylates; Mice; Mutagens; Mutation; Neoplasms, Experimental; Nitrosoguanidines; Time Factors

1973
Enhancement of asparaginase-induced regression of the 6C3HED lymphosarcoma by protein-free diet.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Diet Therapy; Dietary Proteins; Escherichia coli; Female; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred C3H; Neoplasms, Experimental

1973
New asparagine analogs.
    Journal of medicinal chemistry, 1973, Volume: 16, Issue:11

    Topics: Amino Acids, Diamino; Animals; Asparaginase; Asparagine; Cells, Cultured; Escherichia coli; Kinetics; Leukemia, Experimental; Lymphoma; Neoplasms, Experimental; Stereoisomerism; Structure-Activity Relationship

1973
Isoacceptor tRNAs for glutamate, glutamine, aspartate and asparagine in calf brain.
    Journal of neurochemistry, 1974, Volume: 22, Issue:1

    Topics: Animals; Asparagine; Aspartic Acid; Brain; Carbon Radioisotopes; Cattle; Chromatography; Chromatography, Gel; Escherichia coli; Glutamates; Glutamine; Humans; Liver; Liver Regeneration; Lymphocytes; Male; Mice; Neoplasms, Experimental; Organ Specificity; Plasmacytoma; Rats; RNA, Transfer; Species Specificity; Spectrophotometry, Ultraviolet

1974
The measurement of 4-( 14 C)-L-asparagine in body fluids and tissues: methodology and application.
    The Journal of laboratory and clinical medicine, 1973, Volume: 81, Issue:3

    Topics: Amination; Animals; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Carbon Isotopes; Cyclophosphamide; Decarboxylation; Diet; Dogs; Female; Hydrolysis; Ketoglutaric Acids; Lymphoma; Lymphoma, Non-Hodgkin; Malate Dehydrogenase; Methods; Neoplasms, Experimental; Pronase; Proteins; Zinc

1973
Failure of Shier's chemical vaccine to protect BALB-c mice against transplant and chemically induced tumors.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 145, Issue:2

    Topics: Age Factors; Animals; Asparagine; Cell Line; Female; Glycopeptides; Hemagglutination; Lectins; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Multiple Myeloma; Neoplasm Transplantation; Neoplasms, Experimental; Vaccination; Vaccines

1974
Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and -resis
    The Journal of experimental medicine, 1968, Jun-01, Volume: 127, Issue:6

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Cell-Free System; Culture Techniques; Escherichia coli; Female; Glutamine; Leucine; Lymphoma; Male; Mice; Neoplasm Proteins; Neoplasms, Experimental; Rabbits; Rats

1968
Factors which may influence the effectiveness of L-asparaginases as tumor inhibitors.
    British journal of cancer, 1968, Volume: 22, Issue:3

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Escherichia coli; Kinetics; Liver; Lymphoma; Metabolic Clearance Rate; Mice; Neoplasms, Experimental; Rodentia; Spleen

1968
Asparagine synthetase in normal and malignant tissues: correlation with tumor sensitivity to asparaginase.
    Archives of biochemistry and biophysics, 1968, Sep-20, Volume: 127, Issue:1

    Topics: Adenosine Triphosphate; Animals; Asparaginase; Asparagine; Cell Nucleus; Enzyme Repression; Escherichia coli; Feedback; Glutamine; Guinea Pigs; Hydrogen-Ion Concentration; Kidney; Leukemia; Ligases; Liver; Lymphoid Tissue; Lymphoma; Lymphoma, Non-Hodgkin; Lysosomes; Mice; Microsomes; Mitochondria, Liver; Neoplasms, Experimental; Puromycin; Spleen; Stimulation, Chemical

1968
Amino acids of the 6C3HED lymphosarcoma following treatment with asparaginase.
    Cancer research, 1970, Volume: 30, Issue:4

    Topics: Amino Acids; Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Female; Glutamates; Glutamine; Glycine; Liver; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Spleen

1970
Purification and properties of L-asparaginase from Serratia marcescens.
    Journal of bacteriology, 1971, Volume: 106, Issue:2

    Topics: Acrylates; Ammonia; Animals; Asparaginase; Asparagine; Chromatography, DEAE-Cellulose; Cross Reactions; Culture Media; Electrophoresis, Disc; Escherichia coli; Female; Gels; Hydrogen-Ion Concentration; Hydroxyapatites; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Injections, Intraperitoneal; Lymphoma, Non-Hodgkin; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Rabbits; Sarcoma, Experimental; Serratia marcescens; Species Specificity; Spectrophotometry; Ultracentrifugation

1971
Inhibition of murine tumors by carbobenzoxy derivatives of amino acids.
    Israel journal of medical sciences, 1971, Volume: 7, Issue:4

    Topics: Amino Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Benzyl Compounds; Carcinoma, Ehrlich Tumor; Cysteine; Formates; Lymphoma, Non-Hodgkin; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Phenylalanine

1971
Diminished oxidation of 14C-UL-L-asparagine to 14CO2 in mice and humans with tumors: a possible means for assessing efficacy of therapy?
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1970, Volume: 11, Issue:10

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Humans; Injections, Intravenous; Leukemia, Lymphoid; Male; Mice; Multiple Myeloma; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction

1970
Two L-asparaginases from E. coli and their action against tumors.
    Proceedings of the National Academy of Sciences of the United States of America, 1966, Volume: 56, Issue:5

    Topics: Amidohydrolases; Animals; Asparagine; Escherichia coli; Lymphoma; Mice; Neoplasms, Experimental

1966
L-asparaginase: early findings and current studies on the metabolism of L-asparagine in lymphoma cells.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1970, Volume: 33

    Topics: Amino Acyl-tRNA Synthetases; Asparaginase; Asparagine; Aspartic Acid; Cell Line; Chromatography, DEAE-Cellulose; Drug Resistance; Kinetics; Leucine; Lymphoma; Neoplasm Proteins; Neoplasms, Experimental; RNA, Transfer

1970
Asparagine incorporation into the DNA of hepatic and 6C3HED murine lymphosarcoma cells.
    Cancer research, 1970, Volume: 30, Issue:4

    Topics: Amino Acids; Aminohydrolases; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; DNA; DNA, Neoplasm; Liver; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasms, Experimental

1970
Evaluation of L-asparagine metabolism in animals and man.
    Cancer research, 1970, Volume: 30, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Dogs; Erythrocytes; Fluorometry; Hepatectomy; Humans; Hypophysectomy; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Methods; Mice; Neoplasms, Experimental; Rats; Renal Dialysis; Spectrophotometry

1970
The effects of L-asparaginase on the amino acid incorporation of mouse lymphoid tumors.
    Cancer research, 1968, Volume: 28, Issue:5

    Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Leucine; Lymphoma; Mice; Neoplasms, Experimental; Tritium

1968
Uptake of asparagine C-14 into the pyrimidine synthesis pathway of guinea pig serum sensitive 6C3HED lymphosarcoma cells.
    Proceedings of the Western Pharmacology Society, 1968, Volume: 11

    Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Culture Techniques; DNA, Neoplasm; Guinea Pigs; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasms, Experimental; Pyrimidines

1968
The incorporation of l-asparagine-14C by lymphoma 6C3HED cells: its inhibition by guinea pig serum.
    Cancer research, 1966, Volume: 26, Issue:2

    Topics: Animals; Asparagine; Blood; Carbon Isotopes; Guinea Pigs; Lymphoma; Neoplasms, Experimental; Radionuclide Imaging

1966
Antagonism of purified asparaginase from guinea pig serum toward lymphoma.
    Science (New York, N.Y.), 1966, Feb-25, Volume: 151, Issue:3713

    Topics: Amidohydrolases; Animals; Asparagine; Electrophoresis; Guinea Pigs; Immunization, Passive; In Vitro Techniques; Lymphoma, Non-Hodgkin; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Ultracentrifugation

1966
The conversion of [3H]tyrosine to [3H]DOPA in mouse melanoma in vivo.
    Biochimica et biophysica acta, 1966, Jul-27, Volume: 124, Issue:1

    Topics: Animals; Asparagine; Aspartic Acid; Chromatography, Paper; Dihydroxyphenylalanine; Electrophoresis; Glutamates; Glutamine; Melanoma; Mice; Neoplasms, Experimental; Tyrosine

1966