asparagine and Experimental Leukemia

asparagine has been researched along with Experimental Leukemia in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199036 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
FISCHER, GA; HALEY, EE; WELCH, AD1
MASHBURN, LT; WRISTON, JC1
Cooney, DA; Jayaram, HN; Jones, MT; Milman, HA; Young, DM1
Cable, RG; Cooney, DA; King, VD; Taylor, B; Wodinsky, I1
Chang, PK; Handschumacher, RE; Uren, JR1
Brynes, S; Burckart, GJ; Mokotoff, M1
Applebee, S; Cooney, DA; Milman, HA1
Cooney, DA; Milman, HA; Ward, JM1
Cooney, DA; Long, E; Weetall, HH1
Arkin, H; Holland, JF; Minowada, J; Ohnuma, T1
Hageman, JJ; Koomen, GJ; Pandit, UK; Wanner, MJ1
Akiyama, S; Endo, H; Kuwano, M; Nakashima, T1
Albrecht, AM; Biedler, JL; Hutchison, DJ; Spengler, BA; Stockert, E1
Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG1
Keefer, JF; Moraga, DA; Schuster, SM1
Chou, TC; Handschumacher, RE1
Handschumacher, RE; Summers, WP1
Batra, KV; Dolowy, WC; Holcenberg, JS; Roberts, J; Schrek, R1
Handschumacher, RE; Summers, WP; Uren, JR1
Chang, PK; Handschumacher, RE; Sciarini, LJ1
Benvenisty, DS1
Dolowy, WC; Fitzmaurice, MA; Holcenberg, JS; Riley, V; Roberts, J; Spackman, D1
Boyse, EA; Campbell, HA; Old, LJ1
Horowitz, B; Meister, A1
Meister, A; Ubuka, T1
Fletcher, TL; Namkung, MJ1
Andrews, AT; Bates, CJ; Chang, PK; Fischer, GA; Handschumacher, RE1
Bertino, JR; Capizzi, RL; Summers, WP1
Benvenisti, D; Burchenal, JH; Dollinger, M1
Boyse, EA; Campbell, HA; Mashburn, LT; Old, LJ1
Campbell, WF; Levine, AS1
Adamson, RH; Gallo, RC; Longmore, JL1
Balis, ME; Krakoff, IH; Miller, HK; Salser, JS1
Williams, AO1
Capizzi, RL; Cooney, DA; Handschumacher, RE1
Boyes, EA; Horowitz, B; Madras, BK; Meister, A; Old, LJ; Stockert, E1

Other Studies

36 other study(ies) available for asparagine and Experimental Leukemia

ArticleYear
The requirement for L-asparagine of mouse leukemia cells L5178Y in culture.
    Cancer research, 1961, Volume: 21

    Topics: Animals; Asparagine; Leukemia; Leukemia, Experimental; Mice; Tissue Culture Techniques

1961
TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI.
    Archives of biochemistry and biophysics, 1964, Volume: 105

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacillus; Electrophoresis; Escherichia coli; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma; Sarcoma, Experimental

1964
Regulators of the metabolism of L-asparagine: a search for endogenous inhibitors.
    The International journal of biochemistry, 1980, Volume: 11, Issue:6

    Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Edetic Acid; Egtazic Acid; Kinetics; Leukemia L5178; Leukemia, Experimental; Ligases; Liver; Male; Mice; Organ Specificity; Pancreas; Testis

1980
L-Asparagine synthetase in serum as a marker for neoplasia.
    Cancer research, 1976, Volume: 36, Issue:9 pt.1

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Leukemia, Experimental; Ligases; Lomustine; Metabolic Clearance Rate; Mice; Neoplasm Transplantation; Pancreas; Rats; Time Factors

1976
Effects of asparagine synthetase inhibitors on asparaginase resistant tumors.
    Biochemical pharmacology, 1977, Aug-01, Volume: 26, Issue:15

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Line; Culture Media; Drug Resistance; Erwinia; Escherichia coli; In Vitro Techniques; Kinetics; Leukemia, Experimental; Ligases; Mice

1977
Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogues of L-asparagine.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Carcinoma, Hepatocellular; Hydrazines; In Vitro Techniques; Leukemia, Experimental; Ligases; Liver Neoplasms; Mice; Neoplasms, Experimental; Rats; Structure-Activity Relationship; Sulfonamides

1978
A radiometric method for the measurement of L-asparagine synthetase activity: comparison with available methods.
    The International journal of biochemistry, 1978, Volume: 9, Issue:11

    Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carbon Radioisotopes; Cell Line; Guinea Pigs; Leukemia, Experimental; Ligases; Methods; Tissue Distribution

1978
Inhibition of L-asparagine synthetase by mineral cations.
    Toxicology and applied pharmacology, 1979, Sep-30, Volume: 50, Issue:3

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Cations; Dialysis; Glutamine; Leukemia, Experimental; Ligases; Mice; Mice, Inbred Strains; Pancreas; Sulfhydryl Reagents

1979
Biochemical and pharmacologic properties of L-asparaginase bonded to dacron vascular prostheses.
    Biochemical pharmacology, 1975, Feb-15, Volume: 24, Issue:4

    Topics: Animals; Antibody Formation; Antibody Specificity; Asparaginase; Asparagine; Azo Compounds; Blood Vessel Prosthesis; Dogs; Escherichia coli; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Leukemia, Experimental; Mice; Mice, Inbred DBA; Osmolar Concentration; Polyethylene Terephthalates; Pronase; Protein Binding; Stereoisomerism; Temperature; Valine

1975
L-asparagine requirements of human T-lymphocytes and B-lymphocytes in culture.
    Journal of the National Cancer Institute, 1977, Volume: 59, Issue:4

    Topics: Animals; Asparaginase; Asparagine; B-Lymphocytes; Cell Division; Cell Line; Humans; Leukemia, Experimental; Leukemia, Lymphoid; T-Lymphocytes

1977
Potential carcinostatics. Synthesis and biological properties of d- and 1-beta,beta-difluoroaspartic acid and beta,beta-difluoroasparagine.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:12

    Topics: Animals; Antineoplastic Agents; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Division; Cells, Cultured; In Vitro Techniques; Leukemia, Experimental; Mice; Rats; Stereoisomerism

1977
Effect of l-asparaginase and asparagine deprivation on RNA metabolism in mouse leukemia L 5178Y cells in suspension culture.
    Cancer research, 1976, Volume: 36, Issue:10

    Topics: Animals; Asparaginase; Asparagine; Cell Line; Leukemia, Experimental; Neoplasm Proteins; Polyribosomes; RNA, Messenger; RNA, Neoplasm; RNA, Ribosomal

1976
Radiation-induced murine leukemia ERLD in cell culture.
    Cancer research, 1976, Volume: 36, Issue:10

    Topics: Animals; Antigens, Neoplasm; Asparagine; Cell Line; Chromosome Aberrations; Culture Media; Glutamine; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Mercaptoethanol; Mice; Mice, Inbred C57BL

1976
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
    Cancer research, 1985, Volume: 45, Issue:1

    Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid

1985
Comparison of glycine metabolism in mouse lymphoma cells either sensitive or resistant to L-asparaginase.
    Biochemical pharmacology, 1985, Feb-15, Volume: 34, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Chromatography, High Pressure Liquid; Drug Resistance; Glycine; Glyoxylates; Leukemia L5178; Leukemia, Experimental; Mice; Serine

1985
Production of L-asparagine by tumor cells and the effect of asparagine analogs.
    Biochemical pharmacology, 1972, Volume: 21, Issue:1

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Azo Compounds; Bromine; Carbon Isotopes; Carcinoma, Hepatocellular; Chlorine; Glutamine; Kinetics; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Mast Cells; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma 180

1972
The rate of mutation of L5178Y asparagine-dependent mouse leukemia cells to asparagine independence and its biological consequences.
    Cancer research, 1973, Volume: 33, Issue:7

    Topics: Animals; Asparagine; Carbon Isotopes; Cell Division; Cell Line; Cytarabine; Disease Models, Animal; Genes; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Mutation; Phenotype; Time Factors

1973
Effect of asparagine and glutamine deficiency on normal and leukemic cells.
    Journal of the National Cancer Institute, 1973, Volume: 51, Issue:4

    Topics: Animals; Asparagine; Carbon Radioisotopes; Cell Count; Cell Line; Cell Survival; Cells, Cultured; Culture Media; Glutamine; Humans; Lectins; Leucine; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Mice; Neoplasm Proteins

1973
Enzymatic and nutritional evidence for two-stage exression of the asparagine synthetase locus in L5178y murine leukemia mutants.
    Cancer research, 1974, Volume: 34, Issue:11

    Topics: Animals; Asparagine; Cell Division; Cell Line; Enzyme Repression; Genes; Half-Life; Leukemia, Experimental; Leukemia, Lymphoid; Ligases; Mice; Mutation; Time Factors

1974
New asparagine analogs.
    Journal of medicinal chemistry, 1973, Volume: 16, Issue:11

    Topics: Amino Acids, Diamino; Animals; Asparaginase; Asparagine; Cells, Cultured; Escherichia coli; Kinetics; Leukemia, Experimental; Lymphoma; Neoplasms, Experimental; Stereoisomerism; Structure-Activity Relationship

1973
[Inhibition of synthesis of protein and nucleic acid in mouse and human leukemia cells by L-asparaginase in vitro].
    Harefuah, 1972, Jan-16, Volume: 82, Issue:2

    Topics: Animals; Asparaginase; Asparagine; DNA, Neoplasm; Humans; In Vitro Techniques; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm

1972
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
    Cancer research, 1974, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamates; Glutaminase; Glutamine; Half-Life; Hydrogen-Ion Concentration; Isoelectric Focusing; L-Lactate Dehydrogenase; Leukemia, Experimental; Mice; Mice, Inbred C57BL; RNA Viruses

1974
L-asparagine and leukemia.
    Scientific American, 1968, Volume: 219, Issue:2

    Topics: Animals; Asparaginase; Asparagine; Dogs; Escherichia coli; Guinea Pigs; Leukemia; Leukemia, Experimental; Mice; Neoplasm Transplantation

1968
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition.
    The Journal of biological chemistry, 1972, Oct-25, Volume: 247, Issue:20

    Topics: Amino Acids; Ammonium Sulfate; Animals; Asparagine; Aspartic Acid; Bromides; Carbon Isotopes; Catalysis; Chemical Precipitation; Chlorides; Chromatography, Gel; Electrophoresis, Disc; Enzyme Activation; Glutamine; Iodides; Keto Acids; Leukemia, Experimental; Ligases; Mice; Phosphorus Isotopes; Protein Binding; Quaternary Ammonium Compounds

1972
Studies on the utilization of asparagine by mouse leukemia cells.
    Journal of the National Cancer Institute, 1971, Volume: 46, Issue:2

    Topics: Amides; Ammonium Chloride; Animals; Asparagine; Carbon Isotopes; Culture Techniques; DNA, Neoplasm; Glutamine; Leukemia, Experimental; Mice; Neoplasm Proteins; Nitrogen Isotopes; Pentosyltransferases; RNA, Neoplasm

1971
Derivatives of fluorene. 34. N 1 -acetyl-N 2 -fluorenylasparagines.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:5

    Topics: Animals; Asparagine; Fluorenes; Leukemia, Experimental; Mice

1971
5-Diazo-4-oxo-L-norvaline: reactive asparagine analog with biological specificity.
    Science (New York, N.Y.), 1968, Jul-05, Volume: 161, Issue:3836

    Topics: Amino Acids; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Carbon Isotopes; Culture Techniques; DNA; Leucine; Leukemia, Experimental; Leukemia, Lymphoid; Protein Biosynthesis; RNA; Spectrum Analysis; Thymidine; Ultraviolet Rays; Valine

1968
L-asparaginase induced alteration of amethopterin (methotrexate) activity in mouse leukemia L5178Y.
    Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186

    Topics: Animals; Asparaginase; Asparagine; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Female; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Time Factors; Tritium

1971
Experimental studies with L-asparaginase in mouse leukemias.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1970, Volume: 33

    Topics: Animals; Antibiotics, Antineoplastic; Asparaginase; Asparagine; Carmustine; Cell Line; Child, Preschool; Cytarabine; Dactinomycin; Drug Resistance; Drug Synergism; Female; Half-Life; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Neoplasm Proteins; Podophyllin; Pyridines; Stereoisomerism; Thioguanine; Thiosemicarbazones; Time Factors; Tritium; Valine

1970
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
    The Journal of experimental medicine, 1967, Jan-01, Volume: 125, Issue:1

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparagine; Azaserine; Blood; Cyclophosphamide; Escherichia coli; Fluorouracil; Guinea Pigs; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mitomycins; Prednisone; Vincristine

1967
Suppression of Rauscher virus-induced leukemia by L-asparaginase.
    Life sciences, 1969, Oct-15, Volume: 8, Issue:20

    Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Blood; Leukemia, Experimental; Mice; Organ Size; Rauscher Virus; Splenomegaly

1969
Asparaginyl-tRNA and resistance of murine leukaemias to L-asparaginase.
    Nature, 1970, Sep-12, Volume: 227, Issue:5263

    Topics: Animals; Asparaginase; Asparagine; Chromatography; Enzyme Repression; Kinetics; Leukemia L1210; Leukemia, Experimental; Ligases; Mice; RNA, Neoplasm; RNA, Transfer; Stereoisomerism

1970
Sensitivity to L-asparaginase and amino acid metabolism.
    Journal of the National Cancer Institute, 1970, Volume: 44, Issue:5

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Carbon Isotopes; Carcinoma 256, Walker; Citrulline; Culture Techniques; Female; Formates; Glutamine; Half-Life; Humans; Leukemia; Leukemia, Experimental; Male; Mice; Neoplasms; Rats; Spleen; Thymidine; Time Factors; Tritium

1970
Ultrastructural changes in murine leukemia cells exposed to l-asparaginase in vitro.
    American journal of clinical pathology, 1970, Volume: 54, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Cell Line; Culture Techniques; Leukemia, Experimental; Lymphocytes; Mice; Microscopy, Electron

1970
Evaluation of L-asparagine metabolism in animals and man.
    Cancer research, 1970, Volume: 30, Issue:4

    Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Dogs; Erythrocytes; Fluorometry; Hepatectomy; Humans; Hypophysectomy; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Methods; Mice; Neoplasms, Experimental; Rats; Renal Dialysis; Spectrophotometry

1970
Asparagine synthetase activity of mouse leukemias.
    Science (New York, N.Y.), 1968, May-03, Volume: 160, Issue:3827

    Topics: Animals; Asparaginase; Asparagine; Benz(a)Anthracenes; Brain; Diethylstilbestrol; Estrogens; Kidney; Leukemia, Experimental; Leukemia, Radiation-Induced; Ligases; Liver; Lymph Nodes; Male; Methylcholanthrene; Mice; Neoplasm Transplantation; Spleen; Testis; Thymus Gland

1968