asparagine and Disease Models, Animal

asparagine has been researched along with Disease Models, Animal in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19906 (13.64)18.7374
1990's1 (2.27)18.2507
2000's12 (27.27)29.6817
2010's22 (50.00)24.3611
2020's3 (6.82)2.80

Authors

AuthorsStudies
Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X1
Huang, C; Huang, F; Li, B; Lin, D; Wang, S; Xu, C; Zhang, T1
Ahmad, AN; Ahmed, N; Bottino, R; Husain, SZ; Javed, TA; Kilberg, MS; Mukherjee, A; Rose, FT; Wen, L; Xiao, X1
Ahn, EH; Benskey, MJ; Duong, DM; He, L; Iuvone, PM; Jin, L; Kang, SS; Liu, X; Manfredsson, FP; Seyfried, NT; Sun, YE; Wang, JZ; Ye, K; Zhang, Z1
Carey, LA; D'Santos, CS; Dickopf, S; Erard, N; Fish, L; Gable, AL; Goodarzi, H; Hannon, GJ; Harrell, JC; Khan, S; Kim, SY; Knott, SRV; Maceli, AR; Papachristou, EK; Perou, CM; Poulogiannis, G; Soto, M; Turgeon, MO; Wagenblast, E; Wagner, M; Wilkinson, JE1
Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Shiromizu, S1
Ann, DK; Cheng, CT; Chi, KK; Chu, P; Chung, Y; Fu, Y; Kung, HJ; Kuo, CY; Li, CF; Limesand, KH; Lin, HH; Ouyang, C; Sadeghi, M1
de Arruda Campos Brasil de Souza, T; de Castro, E; de Morais, SB; Lancheros Contreras, C; Murakami, MT; Pereira Weiler, AV; Pinge-Filho, P; Souza Morini, F; Yamada-Ogatta, SF1
Chen, J; Jiang, H; Lian, M; Liu, Y; Shan, G; Wu, M; Wu, S; Xu, Y; Zhang, H1
Comuzzie, AG; Cox, LA; Mahaney, MC; Misra, BB; Olivier, M; Puppala, SR; VandeBerg, JL1
Cheng, SH; Gumlaw, N; Jiang, C; Jiang, JL; Karman, J; Lydon, J; Qiu, H; Zhang, J; Zhao, H; Zhou, Q; Zhu, Y1
Jones, JM; Meisler, MH1
Clayton, C; Cordeiro-da-Silva, A; Faria, J; Loureiro, I; Ribeiro, SM; Roy, N; Santarém, N; Tavares, J1
Baruch, M; Belotserkovsky, I; Chen, CY; Cheng, CY; Dov, E; Hanski, E; Hertzog, BB; Le Breton, YS; McIver, KS; Ravins, M; Zhou, Y1
Bottai, D; Brosch, R; Caire-Brandli, I; de Chastellier, C; Dumas, A; Gouzy, A; Guerquin-Kern, JL; Larrouy-Maumus, G; Levillain, F; Neyrolles, O; Poincloux, R; Poquet, Y; Schnappinger, D; Sório de Carvalho, LP; Wallach, JB; Wu, TD1
Ahmer, BM; Ali, MM; Arsenescu, R; Behrman, EJ; Boyaka, PN; Dieye, Y; Dubena, J; Dyszel, JL; González, JF; Krakowka, S; Newsom, DL; Romeo, T; Sabag-Daigle, A; Smith, JN; Stahl, C; Steidley, B; White, P1
Chau, JK; Chung, M; Frank, CB; Hart, DA; Heard, BJ; Mickiewicz, B; Shrive, NG; Vogel, HJ1
Bronson, RT; Hahn, WC; Hettmer, S; Parker, CL; Richards, NG; Schinzel, AC; Schneider, M; Tchessalova, D; Wagers, AJ1
Andrews-Polymenis, H; Bogomolnaya, L; Chen, JS; McClelland, M; McLaughlin, PA; Porwollik, S; van der Velden, AWM; Yang, HJ1
Baloh, RH; Fahrner, T; Le, N; Milbrandt, J; Nagarajan, R; Ryu, E; Strickland, A; Yang, M1
Furukawa, Y; Kaneko, K; Kurosawa, M; Matsumoto, G; Nukina, N1
Hoang, PV; Ito, M; Kawaoka, Y; Kiso, M; Le, QM; Muramoto, Y; Ozawa, M; Sakai-Tagawa, Y; Takano, R; Vuong, CD1
Horimoto, T; Imai, H; Kakugawa, S; Kawaoka, Y; Kiso, M; Le, MT; Noda, T; Ozawa, M; Takahashi, K1
Noda, T; Ortiz, V; Shimoda, M; Sirica, AE; Wands, JR1
Branch, DR; Käsermann, F; Katsman, Y; Leontyev, D; Ma, XZ; Miescher, S1
Alagramam, KN; Askew, C; Chen, DH; Furness, DN; Geng, R; Holt, JR; Horwitz, G; Imanishi, Y; Melki, S; Moser, T; Neef, J; Oshima-Takago, T; Tian, G1
Al Husseini, A; Bogaard, HJ; Cool, CD; Farkas, D; Farkas, L; Gomez-Arroyo, J; Kraskauskas, D; Mizuno, S; Nicolls, MR; Voelkel, NF1
Moremen, KW1
Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K1
Albo, F; Bernardi, G; Ferrari, F; Longone, P; Pascucci, T; Puglisi-Allegra, S; Spalloni, A; Zona, C1
Doe, N; Kitamura, Y; Matsuyama, S; Mori, H; Saito, N; Tanaka, C; Taniguchi, T1
Aitchison, L; Baybutt, H; Cancellotti, E; Manson, JC; Monaghan, P; Simpson, J; Tuzi, NL; Wiseman, F1
Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Smith, KJ; Soleil, V; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G1
Duan, W; Jiang, M; Li, Q; Liang, Y; Masuda, N; Peng, Q; Ross, CA; Wang, W; Wang, X; Zhao, M1
Cadet, JL; Duan, W; Ford, E; Ladenheim, B; Masuda, N; Peng, Q; Ross, CA; Tryggestad, E; Wong, J; Zhao, M1
Bouckaert, J; De Greve, H; Garofalo, C; Hernalsteens, JP; Hultgren, S; Nguyen, H; Oscarson, S; Slättegård, R; Van Gerven, N; Wellens, A; Wyns, L1
Chui, D; Freeze, HH; Fukuda, MN; Lal, A; Liao, YF; Marek, KW; Marth, JD; Moremen, KW; Oh-Eda, M; Panneerselvam, K1
Campbell, RM; Dell, A; Ditto, D; Jaeken, J; Le, D; Levinson, SR; Long, JM; Marth, JD; Morris, HR; Panico, M; Schachter, H; Sutton-Smith, M; Tan, J; Varki, NM; Wang, Y; Wynshaw-Boris, A1
Natori, Y; Okada, M; Oshima, M; Shibata, S; Shindo, N1
Bózner, A; Inczinger, F; Lukaciková, E1
Handschumacher, RE; Summers, WP1
Chang, TM1
Dolowy, WC; Fitzmaurice, MA; Holcenberg, JS; Riley, V; Roberts, J; Spackman, D1
Inczinger, F; Kozlovský, J1

Reviews

2 review(s) available for asparagine and Disease Models, Animal

ArticleYear
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
    Biochimica et biophysica acta, 2002, Dec-19, Volume: 1573, Issue:3

    Topics: Anemia, Dyserythropoietic, Congenital; Animals; Asparagine; Carbohydrates; Disease Models, Animal; Golgi Apparatus; Humans; Mammals; Mannosidases; Mice; Oligosaccharides; Vertebrates

2002
Immobilization of enzymes, adsorbents, or both within semipermeable microcapsules (artificial cells) for clinical and experimental treatment of metabolite-related disorders.
    Birth defects original article series, 1973, Volume: 9, Issue:2

    Topics: Acatalasia; Administration, Oral; Animals; Asparaginase; Asparagine; Catalase; Disease Models, Animal; Enzymes; Injections, Intraperitoneal; Kidney Failure, Chronic; Kidneys, Artificial; Lymphoma, Non-Hodgkin; Membranes, Artificial; Metabolic Diseases; Mice; Neoplasms, Experimental; Permeability; Pharmaceutic Aids; Sarcoma, Experimental; Solubility; Urea; Urease; Uremia

1973

Other Studies

42 other study(ies) available for asparagine and Disease Models, Animal

ArticleYear
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
    Metabolic brain disease, 2022, Volume: 37, Issue:7

    Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Animal; Epilepsy; Glucose; Glutamates; Isoleucine; Ketone Bodies; Lactates; Leucine; Pentylenetetrazole; Pyruvates; Rats; Seizures; Succinates; Valine

2022
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
    Journal of ethnopharmacology, 2023, Jan-10, Volume: 300

    Topics: Alanine; Animals; Asparagine; Aspartic Acid; Cytokines; Disease Models, Animal; Glucose; Histidine; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-8; Magnetic Resonance Spectroscopy; Mice; Moxibustion; Psoriasis; Skin; Taurine; Triglycerides; Valine

2023
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
    Cellular and molecular gastroenterology and hepatology, 2020, Volume: 9, Issue:1

    Topics: Acinar Cells; Animals; Asparaginase; Asparagine; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cell Line; Disease Models, Animal; eIF-2 Kinase; Female; Gene Knockdown Techniques; Humans; Mice; Pancreas; Pancreatitis; Primary Cell Culture; Signal Transduction; Up-Regulation

2020
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
    Nature structural & molecular biology, 2017, Volume: 24, Issue:8

    Topics: alpha-Synuclein; Animals; Asparagine; Cysteine Endopeptidases; Disease Models, Animal; Humans; Mice; Parkinson Disease; Protein Aggregation, Pathological; Proteins; Proteolysis

2017
Asparagine bioavailability governs metastasis in a model of breast cancer.
    Nature, 2018, 02-15, Volume: 554, Issue:7692

    Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Male; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; Prostatic Neoplasms; Reproducibility of Results; RNA Interference

2018
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
    Journal of pharmacological sciences, 2018, Volume: 136, Issue:4

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Drug Chronotherapy; Female; Humans; Infusions, Intravenous; Mice, Inbred BALB C; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2018
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.
    Autophagy, 2018, Volume: 14, Issue:9

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Autophagy; Carcinogenesis; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Energy Metabolism; Humans; Metabolomics; Mice, Knockout; Mitochondria; Mitochondrial Dynamics; Neoplasm Invasiveness; Oxygen Consumption; Prognosis; Proto-Oncogene Proteins p21(ras); Salivary Gland Neoplasms; Survival Analysis

2018
In-solution behavior and protective potential of asparagine synthetase A from Trypanosoma cruzi.
    Molecular and biochemical parasitology, 2019, Volume: 230

    Topics: Ammonia; Animals; Asparagine; Aspartate-Ammonia Ligase; Chagas Disease; Chromatography, Liquid; Circular Dichroism; Disease Models, Animal; Dynamic Light Scattering; Glutamine; Mice, Inbred BALB C; Parasitemia; Protein Conformation; Protein Folding; Protozoan Vaccines; Recombinant Proteins; Trypanosoma cruzi; Vaccines, Synthetic

2019
Intravenous injection of l-aspartic acid β-hydroxamate attenuates choroidal neovascularization via anti-VEGF and anti-inflammation.
    Experimental eye research, 2019, Volume: 182

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Asparagine; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation; Injections, Intravenous; Intravitreal Injections; Mice; Mice, Inbred C57BL; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A; Visual Acuity

2019
Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.
    PloS one, 2019, Volume: 14, Issue:4

    Topics: Animals; Aorta; Aorta, Thoracic; Asparagine; Atherosclerosis; Biomarkers; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Female; Gas Chromatography-Mass Spectrometry; Genotype; Iliac Artery; Lactic Acid; Male; Metabolomics; Papio; Principal Component Analysis; Serum

2019
A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Animals; Antigens; Asparagine; Cell Differentiation; Chickens; CTLA-4 Antigen; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Glycosylation; Histocompatibility Antigens Class II; Mice; Mice, Inbred NOD; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory; Time Factors

2013
Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
    Genesis (New York, N.Y. : 2000), 2014, Volume: 52, Issue:2

    Topics: Animals; Asparagine; Aspartic Acid; Disease Models, Animal; Embryo, Mammalian; Endonucleases; Epilepsy; Frameshift Mutation; Gene Targeting; Homologous Recombination; Humans; Mice; Mice, Inbred C57BL; Mutation, Missense; NAV1.6 Voltage-Gated Sodium Channel; Sequence Analysis, DNA

2014
Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:12

    Topics: Adenosine Triphosphate; Ammonia; Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Disease Models, Animal; Gene Knockdown Techniques; Magnesium; Mice; Mice, Inbred BALB C; Parasitemia; Survival Analysis; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African

2013
An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.
    Cell, 2014, Jan-16, Volume: 156, Issue:1-2

    Topics: Animals; Asparagine; Aspartate-Ammonia Ligase; Bacteremia; Disease Models, Animal; Endoplasmic Reticulum Stress; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Quorum Sensing; Streptococcal Infections; Streptococcus; Transcription, Genetic; Virulence Factors

2014
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.
    PLoS pathogens, 2014, Volume: 10, Issue:2

    Topics: Animals; Asparagine; Chromatography, Liquid; Disease Models, Animal; Female; Flow Cytometry; Gene Knockout Techniques; Immunoblotting; Macrophages; Mass Spectrometry; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Immunoelectron; Mycobacterium tuberculosis; Nitrogen; Phagosomes; Stress, Physiological; Tuberculosis

2014
Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
    PLoS pathogens, 2014, Volume: 10, Issue:6

    Topics: Anaerobiosis; Animals; Asparagine; Bacterial Proteins; Biological Transport; Cation Transport Proteins; Disease Models, Animal; Energy Metabolism; Fructose; Humans; Inflammation; Interleukin-10; Intestinal Mucosa; Intestines; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Salmonella Infections; Salmonella Infections, Animal; Salmonella typhimurium

2014
Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015, Volume: 33, Issue:1

    Topics: Animals; Anterior Cruciate Ligament Reconstruction; Asparagine; Biomarkers; Disease Models, Animal; Female; Glucose; Hydroxyproline; Isobutyrates; Knee Joint; Magnetic Resonance Spectroscopy; Metabolome; Osteoarthritis, Knee; Serine; Sheep; Synovial Fluid; Uridine

2015
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.
    eLife, 2015, Oct-24, Volume: 4

    Topics: Animals; Asparagine; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Silencing; Genetic Testing; Humans; Metabolic Networks and Pathways; Mice; Sarcoma

2015
Contribution of Asparagine Catabolism to Salmonella Virulence.
    Infection and immunity, 2017, Volume: 85, Issue:2

    Topics: Animals; Asparaginase; Asparagine; Catalysis; Cysteine; Disease Models, Animal; Enzyme Stability; Female; Lymphocyte Activation; Macrophages; Mice; Mutation; Nitrogen; Salmonella; Salmonella Infections; Salmonella Infections, Animal; Salmonella typhimurium; T-Lymphocytes; Virulence; Virulence Factors

2017
Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Feb-25, Volume: 29, Issue:8

    Topics: Animals; Asparagine; Cell Line, Transformed; Cell Proliferation; Charcot-Marie-Tooth Disease; Cranial Nerve Diseases; Disease Models, Animal; Early Growth Response Protein 2; Humans; Immunoprecipitation; Isoleucine; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Myelin Proteins; Neoplasm Proteins; Neural Conduction; Ranvier's Nodes; Repressor Proteins; Schwann Cells; Sciatic Nerve

2009
Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Apr-22, Volume: 29, Issue:16

    Topics: Animals; Asparagine; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Glutamine; Humans; Huntingtin Protein; Huntington Disease; Intranuclear Inclusion Bodies; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Protein Structure, Tertiary; Protein Transport; RNA-Binding Proteins; Solubility

2009
Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam.
    The Journal of general virology, 2010, Volume: 91, Issue:Pt 10

    Topics: Animals; Asparagine; Cluster Analysis; Disease Models, Animal; Genotype; Humans; Influenza A Virus, H5N1 Subtype; Influenza, Human; Lysine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthomyxoviridae Infections; Phylogeny; RNA-Dependent RNA Polymerase; RNA, Viral; Sequence Analysis, DNA; Sequence Homology; Vietnam; Viral Proteins; Virulence; Virulence Factors

2010
Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus.
    Journal of virology, 2011, Volume: 85, Issue:10

    Topics: Amino Acid Substitution; Animals; Antiviral Agents; Asparagine; Disease Models, Animal; Drug Resistance, Viral; Female; Ferrets; Influenza A Virus, H5N1 Subtype; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Point Mutation; Rodent Diseases; Serine; Survival Analysis; Treatment Outcome; Viral Proteins; Virulence; Virulence Factors; Virus Replication; Zanamivir

2011
Immunization with aspartate-β-hydroxylase-loaded dendritic cells produces antitumor effects in a rat model of intrahepatic cholangiocarcinoma.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:1

    Topics: Adoptive Transfer; Animals; Asparagine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cells, Cultured; Cholangiocarcinoma; Dendritic Cells; Disease Models, Animal; Humans; Immunization; Interleukin-12; Male; Rats; Rats, Inbred F344; Recombinant Proteins; Spleen

2012
Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin.
    Transfusion, 2012, Volume: 52, Issue:8

    Topics: Animals; Asparagine; Disease Models, Animal; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunoglobulins, Intravenous; Immunologic Factors; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Plant Lectins; Platelet Count; Polysaccharides; Purpura, Thrombocytopenic, Idiopathic; Receptors, IgG; Ribosome Inactivating Proteins; RNA, Messenger

2012
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jul-11, Volume: 32, Issue:28

    Topics: Acoustic Stimulation; Age Factors; Alcohol Oxidoreductases; Animals; Animals, Newborn; Asparagine; Barium; Biophysical Phenomena; Cadherins; Cell Line, Transformed; Cochlea; Disease Models, Animal; DNA-Binding Proteins; Evoked Potentials, Auditory, Brain Stem; Green Fluorescent Proteins; Hair Cells, Auditory; Humans; Lysine; Mechanoreceptors; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Scanning; Mutation; Nerve Fibers; Organ Culture Techniques; Patch-Clamp Techniques; Physical Stimulation; Psychoacoustics; Pyridinium Compounds; Quaternary Ammonium Compounds; Receptors, AMPA; Synapses; Transfection; Usher Syndromes

2012
Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.
    American journal of respiratory cell and molecular biology, 2012, Volume: 47, Issue:5

    Topics: Animals; Antilymphocyte Serum; Apoptosis; Asparagine; B-Lymphocytes; Caspase Inhibitors; Cell Proliferation; Dexamethasone; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunization; Indoles; Interleukin-6; Lung; Male; Ovalbumin; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A

2012
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Disease Models, Animal; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Prospective Studies; Rabbits; Single-Blind Method; Stroke; Taurine; Time Factors

2003
Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones.
    Neuroreport, 2004, Nov-15, Volume: 15, Issue:16

    Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Asparagine; Calcium Channel Blockers; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Transgenic; Motor Neurons; Neurotoxins; Nifedipine; Phosphopyruvate Hydratase; Sodium Channel Blockers; Spinal Cord; Superoxide Dismutase; Tetrodotoxin; Time Factors

2004
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation.
    FEBS letters, 2005, Oct-24, Volume: 579, Issue:25

    Topics: Alzheimer Disease; Animals; Asparagine; Avoidance Learning; Chromosomes, Human, Pair 17; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Lysine; Maze Learning; Mice; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Neurofibrillary Tangles; Phosphorylation; tau Proteins

2005
Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Aging; Alleles; Animals; Antibodies, Monoclonal; Asparagine; Blotting, Northern; Blotting, Southern; Blotting, Western; Brain; Carbohydrates; Cell Membrane; Cells, Cultured; Detergents; Disease Models, Animal; DNA; Embryo, Mammalian; Endopeptidase K; Endoplasmic Reticulum; Female; Genetic Vectors; Genotype; Glycoproteins; Glycosylation; Golgi Apparatus; Homozygote; Immunohistochemistry; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Genetic; Mutation; Neurons; Phenotype; Polymerase Chain Reaction; Polysaccharides; Prions; Recombination, Genetic; RNA; RNA, Messenger; Scrapie; Solubility; Stem Cells; Threonine; Time Factors; Type C Phospholipases

2005
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
    Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Asparagine; Aspartic Acid Endopeptidases; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Disease Models, Animal; Ethylamines; Fluorine; Mice; Molecular Structure; Nanotechnology; Structure-Activity Relationship

2008
Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.
    Neurobiology of disease, 2008, Volume: 30, Issue:3

    Topics: Animals; Arginine; Asparagine; Disease Models, Animal; Female; Glutamine; Huntington Disease; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Neurologic Mutants; Mice, Transgenic; Neuroprotective Agents; Nipecotic Acids; PC12 Cells; Rats; Tiagabine

2008
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease.
    Neurobiology of disease, 2008, Volume: 30, Issue:3

    Topics: Animals; Asparagine; Cell Differentiation; Cell Movement; Disease Models, Animal; Disease Progression; Glutamine; Huntington Disease; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Sertraline

2008
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.
    PloS one, 2008, Apr-30, Volume: 3, Issue:4

    Topics: Adhesins, Escherichia coli; Animals; Anti-Bacterial Agents; Asparagine; Bacterial Adhesion; Biofilms; Cell Line; Crystallography, X-Ray; Cystitis; Disaccharides; Disease Models, Animal; Escherichia coli; Fimbriae Proteins; Fimbriae, Bacterial; Glycosylation; Humans; Intracellular Space; Mannosides; Mice; Oligosaccharides; Protein Structure, Tertiary; Receptors, Cell Surface; Substrate Specificity; Urinary Tract Infections

2008
Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis.
    Cell, 1997, Jul-11, Volume: 90, Issue:1

    Topics: Alleles; Anemia, Dyserythropoietic, Congenital; Animals; Asparagine; Carbohydrate Sequence; Disease Models, Animal; Erythrocyte Membrane; Exons; Frameshift Mutation; Gene Library; Glycolipids; Hematopoietic Stem Cells; Humans; Mannosidases; Mice; Mice, Knockout; Molecular Sequence Data; Oligosaccharides; Phenotype

1997
Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.
    Glycobiology, 2001, Volume: 11, Issue:12

    Topics: Abnormalities, Multiple; Animals; Asparagine; Bone Diseases, Metabolic; Congenital Disorders of Glycosylation; Disease Models, Animal; Glomerulonephritis; Glycosylation; Humans; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Mutation; N-Acetylglucosaminyltransferases; Polysaccharides; Species Specificity; Testis; Tissue Distribution

2001
Nephritogenic glycoprotein. XII. Focal glomerulonephritis with myeloid bodies produced in rats by synthetic analogues of the glycopeptide, nephritogenoside.
    Nephron, 1987, Volume: 47, Issue:2

    Topics: Animals; Asparagine; Cells, Cultured; Disease Models, Animal; Fluorescent Antibody Technique; Glomerulonephritis; Glutamine; Glycopeptides; Humans; Inclusion Bodies; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Rats; Rats, Inbred Strains; Trisaccharides

1987
[Dynamic follow-up study of the influence of K and Mg asparaginate (Cardilan Spofa) on the development of isoprenaline-induced myocardial necroses in the electron microscopy picture].
    Ceskoslovenska patologie, 1974, Volume: 10, Issue:4

    Topics: Animals; Asparagine; Cardiomyopathies; Disease Models, Animal; Heart; Isoproterenol; Magnesium; Microscopy, Electron; Necrosis; Potassium; Rabbits

1974
The rate of mutation of L5178Y asparagine-dependent mouse leukemia cells to asparagine independence and its biological consequences.
    Cancer research, 1973, Volume: 33, Issue:7

    Topics: Animals; Asparagine; Carbon Isotopes; Cell Division; Cell Line; Cytarabine; Disease Models, Animal; Genes; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Mutation; Phenotype; Time Factors

1973
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
    Cancer research, 1974, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamates; Glutaminase; Glutamine; Half-Life; Hydrogen-Ion Concentration; Isoelectric Focusing; L-Lactate Dehydrogenase; Leukemia, Experimental; Mice; Mice, Inbred C57BL; RNA Viruses

1974
[Effect of Cardilan infusion on the arrhythmic and lethal dose of g-strophantin in a model of experimental isoprenaline necrosis].
    Ceskoslovenska farmacie, 1972, Volume: 21, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Asparagine; Disease Models, Animal; Heart; Heart Rate; Injections, Intravenous; Isoproterenol; Necrosis; Ouabain; Rabbits

1972