asparagine has been researched along with Alzheimer Disease in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Song, M | 1 |
| Elahi, M; Hasegawa, M; Hattori, N; Ishiguro, K; Matsumoto, SE; Motoi, Y; Shimonaka, S | 1 |
| Gaunitz, S; Schedin-Weiss, S; Tjernberg, LO | 1 |
| Kawahara, M; Sadakane, Y | 1 |
| Ebashi, M; Hirokawa, K; Kamei, S; Nakamura, A; Toru, S; Uchihara, T; Yokota, T | 1 |
| Derreumaux, P; Li, MS; Ngo, ST; Nguyen, PH; Viet, MH | 1 |
| Akiyama, H; Arai, T; Dan, A; Hasegawa, M; Hatsuta, H; Kametani, F; Kondo, H; Mann, DM; Masuda-Suzukake, M; Murayama, S; Nonaka, T; Saito, Y; Takahashi, M | 1 |
| Berlau, DJ; Cheema, AK; Federoff, HJ; Fiandaca, MS; Fisher, SG; Haley, JM; Hall, WJ; Kawas, CH; MacArthur, LH; Mapstone, M; Mhyre, TR; Nazar, MD; Peltz, CB; Peterson, DR; Rich, SA; Tan, MT; Zhong, X | 1 |
| Gao, J; Guo, Y; Niu, F; Qiu, C; Sun, Y; Tang, W; Wen, H; Ye, L; Yi, X; Yu, S; Zhang, Z | 1 |
| Cheng, L; Duong, DM; Hu, WT; Kang, SS; Kwon, IS; Levey, AI; Liu, X; Liu, Z; Seyfried, NT; Song, M; Sun, YE; Wang, JZ; Ye, K; Yu, SP; Zhang, Z | 1 |
| Bird, TD; Jayadev, S; Klunk, W; Leverenz, JB; Stahl, J; Steinbart, E; Yu, CE | 1 |
| Fassler, M; Kaether, C; Li, X | 1 |
| Cynis, H; Güttler, BH; Ludwig, HH; Porzel, A; Schilling, S; Seifert, F | 1 |
| Cho, HS; Martin-Rehrmann, MD; Rebeck, GW | 1 |
| Blotta, I; Bruni, AC; Campeggi, LM; Cantafora, A; Confaloni, A; Crestini, A; Di Natale, M; Forloni, G; Franceschi, M; Frigerio, CS; Maletta, R; Marcon, G; Perri, M; Piscopo, P; Terreni, L | 1 |
| Hattori, S; Kowa, H; Nakashima, K; Sakuma, K; Shimoda, M; Urakami, K; Wada, K; Wakutani, Y | 1 |
| Santhoshkumar, P; Sharma, KK | 1 |
| Ihara, Y; Mann, DM; Miyasaka, T; Morishima-Kawashima, M; Murayama, S; Nagashima, K; Ravid, R; Saito, Y; Watanabe, A; Yamazaki, M | 1 |
| Caflisch, A; Gorfe, AA | 1 |
| Doe, N; Kitamura, Y; Matsuyama, S; Mori, H; Saito, N; Tanaka, C; Taniguchi, T | 1 |
| Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Smith, KJ; Soleil, V; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G | 1 |
| De Strooper, B; Umans, L; Van Den Berghe, H; Van Leuven, F | 1 |
| Chung, WY; Feng, L; Francis, A; Hays, A; Hendrie, H; Mayeux, R; Nguyen, L; Sahota, A; Stern, Y; Tang, MX; Tycko, B | 1 |
| Condron, MM; Kirkitadze, MD; Teplow, DB | 1 |
| Berriman, J; Finch, JT; Lesk, A; Perutz, MF | 1 |
| Bowen, DM; Esiri, MM; Francis, PT; Hunt, A; Lowe, SL; Najlerahim, A; Palmer, AM; Patel, AJ; Procter, AW; Stratmann, GC | 1 |
2 review(s) available for asparagine and Alzheimer Disease
| Article | Year |
|---|---|
The Asparaginyl Endopeptidase Legumain: An Emerging Therapeutic Target and Potential Biomarker for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Asparagine; Biomarkers; Brain; Cysteine Endopeptidases; Humans; Mammals; Protein Phosphatase 2; tau Proteins | 2022 |
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Asparagine; Humans; Iron; Lewy Body Disease; Metals; Prion Diseases; Prion Proteins | 2018 |
1 trial(s) available for asparagine and Alzheimer Disease
| Article | Year |
|---|---|
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Multiprotein Complexes; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Up-Regulation | 2013 |
23 other study(ies) available for asparagine and Alzheimer Disease
| Article | Year |
|---|---|
Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
Topics: Alzheimer Disease; Amino Acid Sequence; Asparagine; Cell Line, Tumor; Humans; Protein Aggregation, Pathological; Sequence Deletion; tau Proteins | 2020 |
The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease.
Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Asparagine; Brain Chemistry; Cerebral Cortex; Chromatography, Gel; Chromatography, High Pressure Liquid; Epitopes; Female; Fucose; Galactose; Glycoproteins; Hippocampus; Humans; Male; N-Acetylneuraminic Acid; Polysaccharides; Tandem Mass Spectrometry | 2021 |
Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody.
Topics: Alzheimer Disease; Asparagine; Humans; Protein Isoforms; tau Proteins; Tauopathies | 2019 |
Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.
Topics: Alzheimer Disease; Antibodies; Asparagine; Brain; Humans; Immunoblotting; Immunohistochemistry; Microtubules; Mutation; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; Supranuclear Palsy, Progressive; tau Proteins | 2013 |
Plasma phospholipids identify antecedent memory impairment in older adults.
Topics: Aged; Alzheimer Disease; Asparagine; Biomarkers; Carnitine; Cognitive Dysfunction; Cohort Studies; Dipeptides; Female; Humans; Longitudinal Studies; Lysophosphatidylcholines; Malates; Male; Memory Disorders; Metabolome; Neuropsychological Tests; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Proline; Prospective Studies; Sensitivity and Specificity; Sphingomyelins; Ursodeoxycholic Acid | 2014 |
Novel mutation in the PSEN2 gene (N141Y) associated with early-onset autosomal dominant Alzheimer's disease in a Chinese Han family.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Asian People; Asparagine; Codon; Female; Genes, Dominant; Genetic Association Studies; Humans; Male; Middle Aged; Mutation, Missense; Pedigree; Phenotype; Presenilin-2; Tyrosine | 2014 |
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amino Acid Sequence; Animals; Asparagine; Brain; Calpain; Caspases; Cognition; Cysteine Endopeptidases; Gene Knockout Techniques; HEK293 Cells; Humans; Memory Disorders; Mice, Transgenic; Molecular Sequence Data; Neurofibrillary Tangles; Neurotoxins; Phosphorylation; Protein Structure, Tertiary; Solubility; Synapses; tau Proteins; Up-Regulation | 2014 |
Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Asparagine; Female; Genetic Carrier Screening; Genotype; Humans; Isoleucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Presenilin-2 | 2010 |
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
Topics: Alzheimer Disease; Amino Acids; Animals; Asparagine; Binding Sites; Glycosylation; HEK293 Cells; Humans; Mice; Mice, Knockout; Mutation; Presenilin-1; Presenilin-2; Protein Binding; Protein Conformation | 2011 |
A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Isoaspartic Acid; Isomerism; Kinetics; Plaque, Amyloid; Protein Processing, Post-Translational | 2013 |
Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Apolipoproteins E; Asparagine; Brain; Brain Chemistry; DNA Mutational Analysis; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Lipoprotein Lipase; Low Density Lipoprotein Receptor-Related Protein-1; Neurons; Plaque, Amyloid; Point Mutation; Polymorphism, Genetic; Serine | 2002 |
Nicastrin gene in familial and sporadic Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoprotein E4; Apolipoproteins E; Asparagine; Case-Control Studies; Female; Genotype; Humans; Male; Membrane Glycoproteins; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2003 |
A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimer's disease with spastic paraparesis.
Topics: Alzheimer Disease; Asparagine; Female; Humans; Male; Membrane Proteins; Middle Aged; Mutation; Paraparesis, Spastic; Pedigree; Presenilin-1; Tyrosine | 2004 |
Inhibition of amyloid fibrillogenesis and toxicity by a peptide chaperone.
Topics: alpha-Crystallins; Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Asparagine; Benzothiazoles; Cell Survival; Fluorescent Dyes; Humans; Molecular Chaperones; Molecular Sequence Data; PC12 Cells; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Thiazoles; Toxicity Tests | 2004 |
Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads.
Topics: Alzheimer Disease; Antibody Specificity; Asparagine; Blotting, Western; Brain; Brain Chemistry; Cell Fractionation; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunohistochemistry; Isomerism; Neurofibrillary Tangles; Neurons; Neuropil Threads; tau Proteins | 2005 |
Functional plasticity in the substrate binding site of beta-secretase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Asparagine; Aspartic Acid Endopeptidases; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Endopeptidases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Oligopeptides; Protein Conformation; Protein Structure, Secondary; Protons; Serine; Substrate Specificity; Temperature; Tyrosine; Water | 2005 |
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation.
Topics: Alzheimer Disease; Animals; Asparagine; Avoidance Learning; Chromosomes, Human, Pair 17; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Lysine; Maze Learning; Mice; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Neurofibrillary Tangles; Phosphorylation; tau Proteins | 2005 |
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Asparagine; Aspartic Acid Endopeptidases; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Disease Models, Animal; Ethylamines; Fluorine; Mice; Molecular Structure; Nanotechnology; Structure-Activity Relationship | 2008 |
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arginine; Asparagine; Aspartic Acid Endopeptidases; Base Sequence; Cell Compartmentation; Cell Line; Endopeptidases; Methylamines; Mice; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1993 |
Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Asparagine; Base Sequence; Black or African American; Black People; Clusterin; Disease Susceptibility; DNA Primers; Ethnicity; Exons; Genetic Variation; Glycoproteins; Glycosylation; Hispanic or Latino; Histidine; Humans; Molecular Chaperones; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; United States; White People | 1996 |
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloidosis; Asparagine; Aspartic Acid; Chromatography, Gel; Circular Dichroism; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary | 2001 |
Amyloid fibers are water-filled nanotubes.
Topics: Alzheimer Disease; Amyloid; Asparagine; Crystallography, X-Ray; Exons; Fourier Analysis; Fungal Proteins; Glutamine; Humans; Huntingtin Protein; Hydrogen Bonding; Microscopy, Electron; Nerve Tissue Proteins; Nuclear Proteins; Peptide Termination Factors; Peptides; Prions; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins | 2002 |
Topographical distribution of neurochemical changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cerebellar Cortex; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutaminase; Glutamine; Humans; Middle Aged; Somatostatin | 1988 |