asparagine has been researched along with Acute Lymphoid Leukemia in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.23) | 18.7374 |
| 1990's | 10 (12.35) | 18.2507 |
| 2000's | 23 (28.40) | 29.6817 |
| 2010's | 29 (35.80) | 24.3611 |
| 2020's | 18 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, WH | 1 |
| Abdel-Fattah, M; Ataya, FS; El-Nikhely, N; Eldoksh, A; Elkewedi, M; Elsawy, E; Hemida, A; Labrou, NN; Nematalla, H; Saeed, H; Shalaby, M | 1 |
| Andreoli, R; Bardelli, D; Bianchi, MG; Biondi, A; Bussolati, O; Carubbi, C; Chiu, M; D'Amico, G; Dander, E; Fallati, A; Galuppo, L; Mirandola, P; Pozzi, G; Rizzari, C; Tardito, S; Taurino, G | 1 |
| Chan, WK; Chiche, J; Grima-Reyes, M; Lorenzi, PL; Marchetti, S; Martinez-Turtos, A; Meola, P; Nemazanyy, I; Nottet, N; Paul, R; Reverso-Meinietti, J; Ricci, JE; Vandenberghe, A | 1 |
| Darvishi, F; Jahanafrooz, Z; Mokhtarzadeh, A | 1 |
| Bakkali, A; Brigitha, LJ; Pieters, R; Struys, EA; van der Sluis, IM | 1 |
| Chan, WK; De Moerloose, B; De Visser, Y; Goossens, S; Lammens, T; Lavie, A; Lee, H; Lorenzi, PL; Mondelaers, V; Nguyen, HA; Peeters, E; Reunes, L; Schalk, AM; Su, Y; Van Trimpont, M; Van Vlierberghe, P; Vandemeulebroecke, K | 1 |
| Beltrán, JF; Castillo, RL; Farías, JG; Herrera Belén, L; Pedroso, A; Pedroso, E; Pessoa, A | 1 |
| Aidarova, S; Lanka, SS; Mutaliyeva, B; Sharipova, A; Suigenbayeva, A; Talluri, VP; Tleuova, A; Ulaganathan, V | 1 |
| Andjelkovic, M; Ramos-Guzmán, CA; Ruiz-Pernía, JJ; Tuñón, I; Zinovjev, K | 1 |
| Akahane, K; Goi, K; Goto, H; Harama, D; Inukai, T; Kagami, K; Kasai, S; Kitahara, S; Miyake, K; Sakaguchi, K; Sunamura, EI; Tamai, M; Watanabe, A; Yamada, Y; Yotani, T | 1 |
| Attarbaschi, A; Boos, J; Gerss, J; Lanvers-Kaminsky, C; Möricke, A; Nath, C; Rizzari, C; Schrappe, M; Smisek, P; Stary, J; Würthwein, G; Zimmermann, M; Zucchetti, M | 1 |
| Afzal, M; Azeem, F; Muneer, F; Muzammil, S; Nadeem, H; Rasul, I; Siddique, MH; Zubair, M | 1 |
| Alcaro, S; Coricello, A; Radadiya, A; Richards, NGJ; Zhu, W | 1 |
| Daley, RJ; Geyer, MB; Kabel, CC; Lavery, JA; Pappacena, JJ; Park, JH; Rajeeve, S; Stump, SE; Tallman, MS | 1 |
| Florindo Guedes, MI; Freire, DA; Lisboa Magalháes, IC; Tramontina Florean, EOP | 1 |
| Almeida, MR; Bento, HBS; Castro, D; de Paiva, GB; Freire, MG; Marques, ASC; Pedrolli, DB; Santos-Ebinuma, VC; Tavares, APM | 1 |
| Bielawski, JP; Cohen, A; Connors, J; Dunn, KA; Forbrigger, Z; Kulkarni, K; Langille, MGI; MacDonald, T; Penny, SL; Rahman, M; Stadnyk, AW; Van Limbergen, J | 1 |
| Bostrom, B; Marini, B; Messinger, Y; Perissinotti, AJ; Salzer, W | 1 |
| Ardalan, N; Khavari-Nejad, RA; Mirzaie, S; Sepahi, AA | 1 |
| Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Shiromizu, S | 1 |
| Acquaviva-Bourdain, C; Audrain, M; Boissel, N; Dombret, H; Huguet, F; Hunault-Berger, M; Ifrah, N; Leguay, T; Lheritier, V; Pagan, C; Paillassa, J; Thomas, X; Vianey-Saban, C | 1 |
| Fang, Y; Shen, Y; Wang, R; Wang, Y; Webster, TJ; Xu, J; Zhang, Y | 1 |
| Almeida, RV; Bon, EPDS; Ferrara, MA; Gregório Alves Fontão, AP; Jurgilas, PB; Lopes, W; Nascimento, HJ; Sampaio, ALF; Santos, BAFD; Torres, FAG | 1 |
| Abrahamsson, J; Albertsen, BK; Frandsen, TL; Grell, K; Heyman, M; Jónsson, ÓG; Lund, B; Schmiegelow, K; Vettenranta, K; Wolthers, BO | 1 |
| Al-Abodi, HR; Al-Marzoqi, AH; Alghanimi, YK; Fattahi, A; Ghasemian, A; Kadhum, SA; Shokouhi Mostafavi, SK | 1 |
| Fukuda, T; Hayase, T; Kashii, Y; Kawahara, Y; Momoi, MY; Morimoto, A | 1 |
| Keating, GM | 1 |
| Hop, WC; Pieters, R; Tong, WH; van der Sluis, IM | 1 |
| Bussolati, O; Chiu, M; D'Amico, G; Dell'Acqua, F; Franchi-Gazzola, R; Rizzari, C | 1 |
| Albertsen, BK; Frandsen, TL; Henriksen, LT; Nersting, J; Raja, RA; Rosthøj, S; Schrøder, H | 1 |
| Jiang, B; Mu, W; Zhang, T; Zuo, S | 1 |
| Asselin, B; Rizzari, C | 1 |
| Béné, MC; Bonmati, C; Bories, P; Boulland, ML; Bouscary, D; Chevallier, P; Deconinck, E; Dombret, H; Escoffre-Barbe, M; Godfrin, Y; Himberlin, C; Huguet, F; Hunault-Berger, M; Ifrah, N; Lafage-Pochitaloff, M; Legrand, O; Leguay, T; Leprêtre, S; Liens, D; Lissandre, S; Ojeda-Uribe, M; Reman, O; Rousselot, P; Sanhes, L; Turlure, P | 1 |
| Banerji, J | 1 |
| Afanetti, M; Boyer, C; Pardes-Chavanes, P; Poirée, M | 1 |
| Carr, D; Dallapozza, L; Earl, JW; Eslick, AE; Misra, A; Nath, CE | 1 |
| Wang, ES; Wetzler, M; Zeidan, A | 1 |
| Cheng, C; Gajjar, A; Hak, LJ; Hijiya, N; Liu, W; Panetta, JC; Pui, CH; Relling, MV | 1 |
| Audrain, M; Bouige, D; Corradini, N; Legrand, A; Mansuy, A; Méchinaud, F; Mohty, M; Orsonneau, JL; Rozé, JC; Strullu, M; Thomare, P; Vermot-Desroches, C | 1 |
| Gu, LJ; He, YY; Jiang, H; Li, BS; Luo, CY | 1 |
| Cannas, G; Chelghoum, Y; Gougounon, A; Thomas, X | 1 |
| Raetz, EA; Salzer, WL | 1 |
| Bussolati, O; Chiarelli, LR; Covini, D; Digilio, R; Pasquetto, MV; Scotti, C; Tardito, S; Valentini, G | 1 |
| Doble, M; Ln, R; Pulicherla, KK; Rekha, VP | 1 |
| Koltin, D; Naqvi, A; Sung, L; Urbach, SL | 1 |
| Attarbaschi, A; Dworzak, MN; Haas, OA; Hochreiter, D; Hutter, C; Kasper, DC; Kornmüller, R; Mann, G; Pichler, H; Pötschger, U; Steiner, M | 1 |
| Ahn, YM; Hegazy, L; Hiratake, J; Ikeuchi, H; Otokawa, T; Richards, NG; Watanabe, B | 1 |
| Boos, J; Hop, WC; Lanvers-Kaminsky, C; Pieters, R; Tong, WH; van der Sluis, IM | 1 |
| Kataria, M; Kumar, K; Verma, N | 1 |
| Boos, J; Lanvers, C; Pinheiro, JP; Würthwein, G | 1 |
| Langebrake, C; Reinhardt, D; Ritter, J | 1 |
| Appel, IM; Boos, J; den Boer, ML; Lanvers, C; Pieters, R; Pinheiro, JP; Reniers, NC | 1 |
| Arnold, R; Boos, J; Gökbuget, N; Hähling, D; Hartmann, F; Hoelzer, D; Ittel, TH; Langer, W; Mück, R; Müller, HJ; Peter, N; Rosen, O; Rothmann, F; Schwartz, S | 1 |
| Chin, M; Higa, T; Hori, T; Iwai, A; Kuno, T; Maeba, H; Muto, A; Nomura, K; Taga, T; Tsurusawa, M; Yamagata, M | 1 |
| Bodalski, J; Kowalewska-Pietrzak, M; Przybysz, K; Stolarska, M; Zalewska-Szewczyk, B | 1 |
| Bresciani, P; Ferrari, A; Luppi, M; Morselli, M; Potenza, L; Riva, G; Saviola, A; Torelli, G | 1 |
| Avramis, VI; Felgenhauer, JL; Hawkins, DS; Holcenberg, JS; Panosyan, EH; Park, JR; Thomson, BG | 1 |
| Chen, FX; Cui, YQ; Guan, JM; Lai, YH; Lu, CY; Wei, FG; Wu, ZL; Ye, TZ; Zhang, H; Zou, YW | 1 |
| Altman, A; Avramis, VI; Bostrom, B; Breneman, J; Fu, C; Gaynon, PS; Harris, RE; Jarrar, M; Periclou, AP; Steele, D; Stram, D; Trigg, M; Zipf, T | 1 |
| Belevtsev, MV; Buglova, SE; Shman, TV | 1 |
| Kilberg, MS; Richards, NG | 1 |
| Bloomfield, CD; DeOliveira, D; Frankel, SR; Kolitz, JE; Kurtzberg, J; Larson, RA; Powell, BL; Sanford, BL; Wetzler, M | 1 |
| Campana, D; Downing, JR; Iwamoto, S; Mihara, K; Pui, CH | 1 |
| Andrzejewski, W; Bodalski, J; Jedrychowska-Dańska, K; Młynarski, W; Witas, H; Zalewska-Szewczyk, B | 1 |
| Williams, DA | 1 |
| Cohen, MH; Dinndorf, PA; Gootenberg, J; Keegan, P; Pazdur, R | 1 |
| Bode, U; Boos, J; Fleischhack, G; Jürgens, H; Nowak-Göttl, U | 1 |
| Di Cataldo, A; Dibenedetto, SP; Lo Nigro, L; Meli, C; Ragusa, R | 1 |
| Sugimura, K; Sukemori, S | 2 |
| Conter, V; D'Incalci, M; Gentili, D; Masera, G; Zucchetti, M | 1 |
| Boehlein, SK; Dribben, AB; Parr, IB; Richards, NG; Schuster, SM | 1 |
| Ahlke, E; Boos, J; Jürgens, H; Nowak-Göttl, U; Ritter, J; Schulze-Westhoff, P; Verspohl, EJ; Werber, G; Würthwein, G | 1 |
| Boos, J | 1 |
| Ahlke, E; Boos, J; Fleischhack, G; Hempel, G; Lümkemann, K; Mann, G; Müller, HJ; Nowak-Göttl, U; Rath, B; Schrappe, M; Vieira Pinheiro, JP | 1 |
| Gajjar, AJ; Hak, LJ; Harrison, PL; Pui, CH; Relling, MV; Sandlund, JT; Storm, MC; Wang, B; Woo, MH | 1 |
| Aricò, M; Bruno, A; Conter, V; D'Incalci, M; Diomede, L; Gavazzi, L; Lo Nigro, L; Milani, M; Paganini, M; Rizzari, C; Sparano, P; Zucchetti, M | 1 |
| Albertsen, BK; Carlsen, NT; Jakobsen, P; Müller, HJ; Schmiegelow, K; Schrøder, H | 1 |
| Albertsen, BK; Avramis, VI; Carlsen, NT; Ingerslev, J; Jakobsen, P; Müller, HJ; Schmiegelow, K; Schrøder, H | 1 |
| Cheung, RK; Gelfand, EW; Lee, JW; Narasimhan, S; Schachter, H | 1 |
16 review(s) available for asparagine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Microbial L-asparaginase as a promising enzyme for treatment of various cancers.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacteria; Escherichia coli; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
L-Asparaginase delivery systems targeted to minimize its side-effects.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Microbial L-asparaginase: purification, characterization and applications.
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Hodgkin Disease; Humans; Phylogeny; Plants; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
L-asparaginase production review: bioprocess design and biochemical characteristics.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Biotechnology; Dickeya chrysanthemi; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2021 |
Asparaginase activity levels and monitoring in patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Drug Monitoring; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2018 |
Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Escherichia coli; Glutamine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombination, Genetic | 2019 |
Recent research progress on microbial L-asparaginases.
Topics: Acrylamide; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Humans; Hydrolysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Asparaginase pharmacokinetics and implications of therapeutic drug monitoring.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Drug Monitoring; Enzyme Activation; Glutamine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2015 |
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Codon; Gene Expression Regulation; Humans; Peptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Biosynthesis; Ribosomes | 2015 |
Pegasparaginase: where do we stand?
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Drug Hypersensitivity; Drug Resistance, Neoplasm; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
[Therapeutic alternatives to native L-asparaginase in the treatment of adult acute lymphoblastic leukemia].
Topics: Adult; Animals; Antineoplastic Agents; Asparaginase; Asparagine; Clinical Trials as Topic; Dickeya chrysanthemi; Drug Carriers; Drug Interactions; Erythrocytes; Escherichia coli; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Tolerability and efficacy of L-asparaginase therapy in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparagine; Child; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Expanding targets for a metabolic therapy of cancer: L-asparaginase.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Drug Delivery Systems; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Minimising the long-term adverse effects of childhood leukaemia therapy.
Topics: Alkylating Agents; Anthracyclines; Antimetabolites; Antineoplastic Agents; Asparaginase; Asparagine; Cardiovascular Diseases; Child; Clinical Trials as Topic; Glucocorticoids; Gonadal Disorders; Humans; Leukemia; Leukemia, Myeloid, Acute; Osteonecrosis; Podophyllotoxin; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tretinoin; Vinca Alkaloids | 2002 |
Asparagine synthetase chemotherapy.
Topics: Antineoplastic Agents; Asparagine; Aspartate-Ammonia Ligase; Binding Sites; Cell Cycle; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured | 2006 |
12 trial(s) available for asparagine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Infant; Male; Osteonecrosis; Pancreatitis; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Risk; Thromboembolism; Treatment Outcome | 2019 |
A Phase 2 study of L-asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: The GRASPALL/GRAALL-SA2-2008 study.
Topics: Aged; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Drug Carriers; Drug Compounding; Erythrocytes; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Male; Middle Aged; Mycoses; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Analysis | 2015 |
Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia.
Topics: Antibodies; Antineoplastic Agents; Asparaginase; Asparagine; Computer Simulation; Escherichia coli; Humans; Models, Biological; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Recurrence; Treatment Failure | 2009 |
Silent hypersensitivity to Escherichia coli asparaginase in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antibodies, Anti-Idiotypic; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate | 2010 |
No evidence of increased asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
L-Asparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Feasibility Studies; Humans; Immunophenotyping; Middle Aged; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome | 2007 |
FDA drug approval summary: pegaspargase (oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL).
Topics: Antibodies; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Disease-Free Survival; Drug Approval; Female; Humans; Infant; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; United States; United States Food and Drug Administration | 2007 |
Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Erwinia; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors | 1995 |
Pharmacokinetics and drug monitoring of L-asparaginase treatment.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Monitoring; Erwinia; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism | 1997 |
L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Escherichia coli; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2000 |
Monitoring of Erwinia asparaginase therapy in childhood ALL in the Nordic countries.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Infant; Injections, Intramuscular; Injections, Intravenous; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Scandinavian and Nordic Countries | 2001 |
53 other study(ies) available for asparagine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Comment on "Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase".
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
L-asparaginase from
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Dickeya chrysanthemi; Escherichia coli; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats | 2022 |
ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment.
Topics: Asparaginase; Asparagine; Bone Marrow Cells; Humans; Mesenchymal Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Line, Tumor; Glutaminase; Lymphoma, B-Cell; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Microenvironment | 2022 |
Depletion of d- and l-asparagine in cerebrospinal fluid in acute lymphoblastic leukemia during PEGasparaginase therapy.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Glutamine; Humans; Infant; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Topics: Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Glutaminase; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
In Silico Design of a Chimeric Humanized L-asparaginase.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Escherichia coli; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Fusion Proteins | 2023 |
Elucidation of the Active Form and Reaction Mechanism in Human Asparaginase Type III Using Multiscale Simulations.
Topics: Animals; Asparaginase; Asparagine; Humans; Mammals; Multienzyme Complexes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Subunits | 2023 |
Utility of
Topics: Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA Methylation; Humans; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Inactivation, Metabolic; Infant; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Improving the Treatment of Acute Lymphoblastic Leukemia.
Topics: Adolescent; Asparaginase; Asparagine; Child; Child, Preschool; Glutaminase; Humans; Medical Oncology; Models, Molecular; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Quality Improvement; Young Adult | 2020 |
Tolerability and toxicity of pegaspargase in adults 40 years and older with acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Agents; Asparaginase; Asparagine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Genes, Bacterial; Glutamic Acid; Glutamine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Catalytic Domain; Drug Design; Escherichia coli Proteins; Glutamine; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutation, Missense; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Protein Conformation; Quantum Theory; Substrate Specificity; Thermodynamics | 2018 |
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Drug Chronotherapy; Female; Humans; Infusions, Intravenous; Mice, Inbred BALB C; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
Monitoring of asparagine depletion and anti-L-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial.
Topics: Asparaginase; Asparagine; Child; Clinical Trials, Phase III as Topic; Female; Humans; Isoantibodies; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
Personalized nanomedicine: a rapid, sensitive, and selective UV-vis spectrophotometry method for the quantification of nanostructured PEG-asparaginase activity in children's plasma.
Topics: Asparaginase; Asparagine; Child; Humans; Hydrolysis; Limit of Detection; Nanomedicine; Nanostructures; Polyethylene Glycols; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2018 |
Expression, purification, and characterization of asparaginase II from Saccharomyces cerevisiae in Escherichia coli.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Bacterial Proteins; Cell Line, Tumor; Cloning, Molecular; Escherichia coli; Gene Expression; Glutamine; Humans; Molecular Weight; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Saccharomyces cerevisiae | 2019 |
Monitoring of anti-L-asparaginase antibody and L-asparaginase activity levels in a pediatric patient with acute lymphoblastic leukemia and hypersensitivity to native Escherichia coli L-asparaginase during desensitization courses.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Asparaginase Erwinia chrysanthemi (Erwinaze®): a guide to its use in acute lymphoblastic leukemia in the USA.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Bacterial Proteins; Drug Hypersensitivity; Drug Monitoring; Drugs, Investigational; Enzyme Therapy; Erwinia; Escherichia coli Proteins; Humans; Injections, Intramuscular; Polyethylene Glycols; Practice Guidelines as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States | 2013 |
Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Asparaginase; Asparagine; Bone Marrow; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.
Topics: Asparaginase; Asparagine; Bone Marrow; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Cerebrospinal fluid asparagine depletion during pegylated asparaginase therapy in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; Female; Glutamine; Humans; Infant; Injections, Intramuscular; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Specimen Handling | 2014 |
[Fatal central nervous system hemorrhage during acute lymphoblastic leukemia induction].
Topics: Antineoplastic Agents; Asparagine; Child; Fatal Outcome; Female; Humans; Intracranial Hemorrhages; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Stability; Escherichia coli Proteins; Fluorescence; Glutamic Acid; Glutamine; Homoserine; Humans; Least-Squares Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
[Relationship between the antileukemic activity of L-asparaginase and Asn level around leukemic cells].
Topics: Asparaginase; Asparagine; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Humans; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Topics: Asparaginase; Asparagine; Catalytic Domain; Child; Computer Simulation; Drug Design; Glutaminase; Glutamine; Humans; Ligands; Mutagenesis, Site-Directed; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Engineering | 2011 |
Medication induced diabetes during induction in pediatric acute lymphoblastic leukemia: prevalence, risk factors and characteristics.
Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Asparagine; Child; Child, Preschool; Confidence Intervals; Dexamethasone; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Induction Chemotherapy; Infant; Male; Odds Ratio; Ontario; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Factors; Vincristine | 2012 |
Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during Berlin-Frankfurt-Münster-based induction therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Child; Child, Preschool; Daunorubicin; Drug Administration Schedule; Female; Glutamic Acid; Glutamine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Treatment Outcome; Vincristine | 2012 |
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Topics: Amidohydrolases; Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Imines; Models, Molecular; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sulfur Compounds | 2012 |
Plant asparaginase-based asparagine biosensor for leukemia.
Topics: Agar; Alginates; Asparaginase; Asparagine; Biosensing Techniques; Color; Gelatin; Glucuronic Acid; Hexuronic Acids; Humans; Immobilized Proteins; Limit of Detection; Plant Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sepharose; Time Factors | 2013 |
Pharmacology of PEG-asparaginase in childhood acute lymphoblastic leukemia (ALL).
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Escherichia coli; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recombinant Proteins | 2002 |
Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Humans; Injections, Intravenous; Metabolic Clearance Rate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2003 |
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Blood Coagulation; Drug Administration Schedule; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2003 |
[Iatrogenic hyperlipidemia after l-asparaginase and glucocorticoid treatment in two children with acute lymphoblastic leukemia].
Topics: Adolescent; Anti-Inflammatory Agents; Asparagine; Female; Humans; Hyperlipidemias; Iatrogenic Disease; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2003 |
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Daunorubicin; Echocardiography; Humans; Male; Myocardial Ischemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vincristine | 2004 |
Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Delayed-Action Preparations; Female; Glutamine; Humans; Immunophenotyping; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2004 |
[Research on the pharmacokinetics and pharmacodynamics of L-asparaginase during its treatment of childhood acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2005 |
Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941).
Topics: Antibody Formation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Child; Female; Glutamic Acid; Humans; Injections, Intramuscular; Male; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Statistics, Nonparametric | 2006 |
[Drug sensitivity of tumor cells in varieties of acute childhood leukemia].
Topics: Antigens, CD34; Antineoplastic Agents; Apoptosis; Asparagine; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tumor Cells, Cultured; Vincristine | 2005 |
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Bone Marrow Cells; Cell Division; Child; Gene Expression Profiling; Humans; Mesenchymal Stem Cells; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
The anti-asparagines antibodies correlate with L-asparagines activity and may affect clinical outcome of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antibodies; Asparagine; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Immunoglobulin G; Immunoglobulin M; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Treatment Outcome | 2007 |
A new mechanism of leukemia drug resistance?
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Bone Marrow Cells; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Mesenchymal Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Loss of activity of Erwinia asparaginase on repeat applications.
Topics: Asparaginase; Asparagine; Child; Erwinia; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
Inhibition of cultured leukemia cell growth by enhanced adriamycin cytotoxicity with reduction of glutamine or asparagine level in medium.
Topics: Animals; Asparagine; Cell Division; Culture Media; Doxorubicin; Glutamine; Humans; Leukemia P388; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Tumor Cells, Cultured | 1994 |
Determination of L-asparagine in biological samples in the presence of L-asparaginase.
Topics: Asparaginase; Asparagine; Benzenesulfonates; Chromatography, High Pressure Liquid; Drug Stability; Erwinia; Erythrocytes; Freezing; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Salicylates; Sensitivity and Specificity | 1994 |
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Topics: Alkylation; Antineoplastic Agents; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Bacterial Proteins; Binding Sites; Drug Design; Enzyme Inhibitors; Escherichia coli; Glutamine; Humans; Isoenzymes; Kinetics; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1996 |
Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Pharmacokinetic dose adjustment of Erwinia asparaginase in protocol II of the paediatric ALL/NHL-BFM treatment protocols.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Erwinia; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Child; Child, Preschool; Female; Humans; Infant; Injections, Intramuscular; Likelihood Functions; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1999 |
Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system.
Topics: Absorption; Antibodies; Asparaginase; Asparagine; Bacterial Proteins; Biological Availability; Blood Coagulation; Child; Dose-Response Relationship, Drug; Erwinia; Escherichia coli; Humans; Injections, Intramuscular; Liver; Liver Function Tests; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Remission Induction | 2001 |
Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III activity in human B and T lymphocyte lines and in tonsillar B and T lymphocytes.
Topics: Acetylglucosamine; Asparagine; B-Lymphocytes; Cell Line, Transformed; Glucosyltransferases; Herpesvirus 4, Human; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mannose; Methylation; N-Acetylglucosaminyltransferases; Oligosaccharides; Palatine Tonsil; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes; Tumor Cells, Cultured | 1988 |