asoxime chloride has been researched along with Organophosphate Poisoning in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (23.64) | 18.7374 |
| 1990's | 12 (21.82) | 18.2507 |
| 2000's | 13 (23.64) | 29.6817 |
| 2010's | 14 (25.45) | 24.3611 |
| 2020's | 3 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Cashman, JR; Kalisiak, J; Ralph, EC; Zhang, J | 1 |
| Baati, R; Calas, AG; Coisne, C; Courageux, C; Da Silva, O; Dehouck, MP; Dias, J; Gastellier, AJ; Gosselet, F; Hanak, AS; Jean, L; Landry, C; Nachon, F; Probst, N; Renard, PY; Trancart, M; Warnault, P | 1 |
| Cai, Q; Quan, D; Shen, L; Wang, Y; Yang, J; Zhang, Y | 1 |
| Andrýs, R; Karasová, JŽ; Kassa, J; Klusoňová, A; Lísa, M | 1 |
| Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V | 1 |
| Green, AC; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL | 1 |
| Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M | 1 |
| Aas, P; Myhrer, T | 1 |
| Aas, P; Enger, S; Mariussen, E; Myhrer, T | 1 |
| Kovarik, Z; Maček Hrvat, N; Radić, Z; Taylor, P; Žunec, S | 1 |
| Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Bajgar, J; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S | 1 |
| Aurbek, N; Eyer, F; Eyer, P; Thiermann, H; Worek, F | 1 |
| Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Misik, J; Pavlikova, R | 1 |
| Bajgar, J; Blaha, V; Cabal, J; Fusek, J; Karasova, JZ; Kassa, J; Tesarova, S | 1 |
| Bajgar, J | 1 |
| Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW | 1 |
| Antonijević, B; Bokonjić, D; Stojiljković, MP; Vucinić, S | 1 |
| Armstrong, SJ; Docx, CJ; Green, AC; Mumford, H; Price, ME; Tattersall, JE | 1 |
| Kassa, J; Krejèová, G | 1 |
| Berger, BJ; Davidson, C; Hamilton, MG; Hill, I; Lecavalier, P; Lundy, PM; Vair, C; Weatherby, KL | 1 |
| Bartosová, L; Kuca, K; Kunesová, G | 1 |
| Amitai, G; Lundy, PM; Raveh, L | 1 |
| Jun, D; Kassa, J; Kuca, K | 1 |
| Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Humlicek, V; Kassa, J | 1 |
| Smith, AP; Wolthuis, OL | 1 |
| Benschop, HP; Van Helden, HP; Wolthuis, OL | 1 |
| Smith, AP; Van der Wiel, HJ; Wolthuis, OL | 1 |
| Bosković, B; Cetković, S; Cosić, M; Cvetković, M; Jandrić, D | 1 |
| Bosković, B; Jovanović, D; Kovacević, V | 1 |
| Fonnum, F; Lyngaas, S; Sterri, SH | 1 |
| Clement, JG; Lockwood, PA | 1 |
| Dola, T; Lipp, J | 1 |
| Kleine, A; Szinicz, L; Worek, F | 1 |
| Kirchner, T; Szinicz, L; Worek, F | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Cassel, G; Göransson-Nyberg, A; Jeneskog, T; Karlsson, L; Larsson, R; Lundström, M; Persson, SA | 1 |
| Kassa, J | 1 |
| Bruijnzeel, PL; Busker, RW; Melchers, BP; van Helden, HP | 1 |
| Bajgar, J; Kassa, J | 1 |
| Blanchet, G; Carlsson Bratt, I; Clair, P; Granelli, I; Wiberg, K | 1 |
| Bradamante, V; Domijan, AM; Jukić, I; Lucić, A; Milković-Kraus, S; Peraica, M; Radić, B; Skare, D | 1 |
| Dochterman, LW; Gresham, VC; Kaminskis, A; Koplovitz, I; Stewart, JR | 1 |
| Boulet, CA; Clement, JG; Hansen, AS | 1 |
| Clement, JG | 1 |
| Busker, RW; de Lange, J; Melchers, BP; van Helden, HP | 1 |
| Demerseman, P; Garrigue, H; Godeneche, D; Hulot, T; Madelmont, JC; Maurizis, JC; Morge, X; Nicolas, C; Sentenac-Roumanou, H; Veyre, A | 1 |
| Brzin, M; Dekleva, A; Sket, D; Sketelj, J | 1 |
| Hamilton, MG; Lundy, PM | 1 |
| Clement, JG; Shiloff, JD | 1 |
| Clement, JG; Gennings, C; Shiloff, JD | 1 |
| Pantelić, D | 1 |
5 review(s) available for asoxime chloride and Organophosphate Poisoning
| Article | Year |
|---|---|
Choice of approaches in developing novel medical countermeasures for nerve agent poisoning.
Topics: Animals; Anticonvulsants; Antidotes; Brain; Cholinergic Agents; Humans; Levetiracetam; Organophosphate Poisoning; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Seizures | 2014 |
Optimal choice of acetylcholinesterase reactivators for antidotal treatment of nerve agent intoxication.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Organophosphate Poisoning; Oximes; Pyridinium Compounds | 2010 |
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Humans; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Papio; Poisoning; Pyridinium Compounds | 2006 |
Pharmacological effects of oximes: how relevant are they?
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Organophosphate Poisoning; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Receptors, Cholinergic; Respiration; Soman; Synaptic Transmission | 1996 |
50 other study(ies) available for asoxime chloride and Organophosphate Poisoning
| Article | Year |
|---|---|
Amidine-oximes: reactivators for organophosphate exposure.
Topics: Acetylcholinesterase; Amidines; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Enzyme Reactivators; Female; Humans; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Permeability; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2011 |
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sugars | 2022 |
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning.
Topics: Animals; First Aid; Liposomes; Nerve Agents; Organophosphate Poisoning | 2023 |
Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.
Topics: Acetylcholinesterase; Animals; Area Under Curve; Blood-Brain Barrier; Bridged-Ring Compounds; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Carriers; Enzyme Assays; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Mass Spectrometry; Mice; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Sarin | 2021 |
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime | 2018 |
Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Endpoint Determination; Guinea Pigs; Injections, Intramuscular; Lethal Dose 50; Nicotinic Antagonists; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman; Survival Analysis | 2018 |
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors | 2018 |
Prophylactic potential of memantine against soman poisoning in rats.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; GPI-Linked Proteins; Male; Memantine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Soman; Synaptic Transmission | 2019 |
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman | 2015 |
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.
Topics: Acetylcholinesterase; Animals; Binding Sites; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Male; Mice; Mutagenesis, Site-Directed; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Recombinant Proteins; Survival Rate | 2016 |
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2008 |
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
Topics: Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome | 2009 |
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar | 2009 |
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Topics: Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds | 2009 |
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar | 2010 |
Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo.
Topics: Acetylcholinesterase; Animals; Central Nervous System; Cholinesterase Reactivators; Drug Therapy, Combination; Enzyme Activation; Female; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2010 |
[Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos].
Topics: Animals; Antidotes; Cholinesterase Reactivators; Dichlorvos; Drug Therapy, Combination; Male; Memantine; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman | 2011 |
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Diazepam; Guinea Pigs; Humans; Injections, Intramuscular; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds | 2013 |
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar | 2003 |
The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning.
Topics: Animals; Atropine; Chemical Warfare Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neuroprotective Agents; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman; Swine; Time Factors | 2005 |
Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats.
Topics: Animals; Cholinesterase Reactivators; Female; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats | 2005 |
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
Topics: Animals; Antidotes; Brain; Butanes; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Structure-Activity Relationship | 2007 |
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime | 2008 |
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime | 2008 |
HI6 as an antidote to soman poisoning in rhesus monkey respiratory muscles in-vitro.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Female; Intercostal Muscles; Macaca mulatta; Male; Muscle Contraction; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman | 1983 |
New simulators in the prophylaxis against soman poisoning: structural specificity for the depot site(s).
Topics: Animals; Antidotes; Atropine; Chemical Phenomena; Chemistry, Physical; Male; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Structure-Activity Relationship; Synaptic Transmission | 1984 |
Analysis of oxime-induced neuromuscular recovery in guinea pig, rat and man following soman poisoning in vitro.
Topics: Aged; Animals; Diaphragm; Guinea Pigs; Humans; In Vitro Techniques; Intercostal Muscles; Male; Middle Aged; Neuromuscular Junction; Organ Specificity; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity; Synaptic Transmission; Time Factors | 1981 |
Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat.
Topics: Animals; Atropine; Choline; Cholinesterase Reactivators; Cholinesterases; Female; Guinea Pigs; Heart; Humans; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Organophosphate Poisoning; Organophosphates; Oximes; Phrenic Nerve; Pralidoxime Compounds; Pyridinium Compounds; Rats; Thiocholine | 1984 |
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity | 1984 |
Cholinesterase and carboxylesterase activities in soman poisoned rats treated with bispyridinium mono-oximes HI-6 and HS-6.
Topics: Animals; Antidotes; Carboxylic Ester Hydrolases; Cholinesterases; Male; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Tritolyl Phosphates | 1983 |
HI-6, an oxime which is an effective antidote of soman poisoning: a structure-activity study.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterases; Male; Mice; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Structure-Activity Relationship | 1982 |
comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkey.
Topics: Animals; Atropine; Cholinesterases; Clonazepam; Electroencephalography; Female; Heart Rate; Macaca mulatta; Male; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Respiration; Soman | 1980 |
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration | 1995 |
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Treatment of organophosphate poisoning in pigs: antidote administration by a new binary autoinjector.
Topics: Animals; Antidotes; Atropine; Drug Combinations; Injections, Intramuscular; Injections, Jet; Male; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman; Swine | 1995 |
A comparison of two oximes (HI-6 and obidoxime) for 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterases; Corticosterone; Diaphragm; Liver; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase | 1995 |
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 1996 |
Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning.
Topics: Antidotes; Atropine; Cholinergic Antagonists; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Diazepam; Dipeptides; Drug Combinations; Drug Stability; Organophosphate Poisoning; Oximes; Prodrugs; Pyridinium Compounds | 2000 |
Adamantyl tenocyclidines--adjuvant therapy in poisoning with organophosphorus compounds and carbamates.
Topics: Adamantane; Animals; Antidotes; Atropine; Carbamates; Cholinesterase Reactivators; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred CBA; Organophosphate Poisoning; Oximes; Poisoning; Pyridinium Compounds | 2002 |
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide | 1992 |
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman | 1992 |
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 1992 |
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.
Topics: Animals; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Respiratory Insufficiency; Synaptic Transmission | 1991 |
Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Carbon Radioisotopes; Cartilage; Cholinesterase Reactivators; Feces; Glycosaminoglycans; Half-Life; Imidazoles; Intervertebral Disc; Kidney; Male; Molecular Structure; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Tissue Distribution | 1990 |
Attenuation of soman-induced lesions of skeletal muscle by acetylcholinesterase reactivating and non-reactivating antidotes.
Topics: Acetylcholinesterase; Animals; Antidotes; Male; Muscles; Organophosphate Poisoning; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman | 1989 |
HI-6 therapy of soman and tabun poisoning in primates and rodents.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Respiratory Muscles; Soman | 1989 |
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin | 1987 |
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman | 1987 |
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |