asialo-gm1-ganglioside has been researched along with Uveitis* in 1 studies
1 other study(ies) available for asialo-gm1-ganglioside and Uveitis
| Article | Year |
|---|---|
In vivo expression of perforin by natural killer cells during a viral infection. Studies on uveitis produced by herpes simplex virus type I.
A potent cytolytic pore-forming protein (PFP, perforin, or cytolysin) is associated with the cytoplasmic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. The role of PFP/perforin in cytolytic reactions carried out in vivo is still unclear. Here, the authors performed immunohistochemical analysis using antibodies monospecific for perforin and made use of a murine uveitis model produced by intracameral inoculation of herpes simplex virus I (HSV-I). The main cell infiltrate found in the anterior segment of virus-inoculated eyes consisted of Thy-1+/asialo GM1+/CD8-/CD4- cells, presumably representing NK cells. Perforin staining was detected mainly in cells bearing this phenotype. Perforin was only detected in cells displaying the large granular lymphocyte morphology. A small number of perforin-positive cells (less than 5%) colabeled as CD8+, indicating that these cells could have belonged to the CTL lineage. These observations show for the first time the presence of perforin-containing NK cells in tissues of animals undergoing acute viral infections. Topics: Animals; Antibody Specificity; Fluorescent Antibody Technique; G(M1) Ganglioside; Glycosphingolipids; Herpes Simplex; Immune Sera; Killer Cells, Natural; Lymphocytes; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred BALB C; Perforin; Pore Forming Cytotoxic Proteins; T-Lymphocytes, Cytotoxic; Uveitis; Virus Diseases | 1990 |