asialo-gm1-ganglioside has been researched along with Lymphoma--T-Cell* in 1 studies
1 other study(ies) available for asialo-gm1-ganglioside and Lymphoma--T-Cell
| Article | Year |
|---|---|
Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody.
To develop an experimental model of adult T-cell leukemia/lymphoma in small animals, severe combined immunodeficiency (SCID) mice treated with anti-asialo GM-1 antibody were inoculated with MT-2 cells, a cell line transformed by the human T-cell leukemia virus (HTLV-I). Three mice injected with 4 x 10(7) cells subcutaneously or intramuscularly developed tumors at or near inoculation sites. Immunofluorescent antibody (IFA) staining for HTLV-I structural protein, p19, revealed the specific antigen in the cytoplasm of most cells from tumors and the DNA signals of HTLV-I proviral DNA were also positive in cellular DNA by polymerase chain reaction assay with HTLV-I tax gene primers, SK43/SK44. The MT-2 cells did not invade in mouse organs. Topics: Animals; Antibodies; Cell Line, Transformed; Cell Transformation, Viral; DNA, Neoplasm; Fluorescent Antibody Technique; G(M1) Ganglioside; Human T-lymphotropic virus 1; Humans; Leukemia, T-Cell; Lymphoma, T-Cell; Mice; Mice, SCID; Neoplasm Transplantation; Polymerase Chain Reaction; T-Lymphocytes; Transplantation, Heterologous | 1992 |