asialo-gm1-ganglioside and Cerebellar-Ataxia

asialo-gm1-ganglioside has been researched along with Cerebellar-Ataxia* in 1 studies

Other Studies

1 other study(ies) available for asialo-gm1-ganglioside and Cerebellar-Ataxia

Article	Year
Cerebellar ataxia and polyneuropathy in a patient with IgM M-protein specific to the Gal(beta 1-3)GalNAc epitope. Journal of the neurological sciences, 1994, Volume: 126, Issue:2 A 79-year-old man with sensory dominant polyneuropathy, cerebellar ataxia, and palatal myoclonus had serum IgM M-protein that specifically bound to GM1, GD1b, and asialo-GM1. IgM with the same specificity was detected in his cerebrospinal fluid. Results of immunohistochemical studies showed specific binding of this monoclonal IgM to the cerebellar granular layer, dentate nucleus, inferior olive, and gray matter of the cerebrum and spinal cord. Monoclonal antibody GGR12, monospecific to GD1b, had an immunostaining distribution similar to that of the patient's IgM M-protein. The binding of M-protein may be associated with the development of cerebellar ataxia and palatal myoclonus in this patient. Topics: Aged; Antigens, Tumor-Associated, Carbohydrate; Cerebellar Ataxia; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Epitopes; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin M; Immunohistochemistry; Male; Myelin Proteins; Peripheral Nervous System Diseases	1994

Article

Year

Cerebellar ataxia and polyneuropathy in a patient with IgM M-protein specific to the Gal(beta 1-3)GalNAc epitope.

Journal of the neurological sciences, 1994, Volume: 126, Issue:2

A 79-year-old man with sensory dominant polyneuropathy, cerebellar ataxia, and palatal myoclonus had serum IgM M-protein that specifically bound to GM1, GD1b, and asialo-GM1. IgM with the same specificity was detected in his cerebrospinal fluid. Results of immunohistochemical studies showed specific binding of this monoclonal IgM to the cerebellar granular layer, dentate nucleus, inferior olive, and gray matter of the cerebrum and spinal cord. Monoclonal antibody GGR12, monospecific to GD1b, had an immunostaining distribution similar to that of the patient's IgM M-protein. The binding of M-protein may be associated with the development of cerebellar ataxia and palatal myoclonus in this patient.

Topics: Aged; Antigens, Tumor-Associated, Carbohydrate; Cerebellar Ataxia; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Epitopes; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin M; Immunohistochemistry; Male; Myelin Proteins; Peripheral Nervous System Diseases

1994