Page last updated: 2024-09-04

asenapine and Schizophrenia

asenapine has been researched along with Schizophrenia in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (14.29)29.6817
2010's54 (70.13)24.3611
2020's12 (15.58)2.80

Authors

AuthorsStudies
Shahid, M; Walker, GB; Wong, EH; Zorn, SH1
Hibino, H; Inoue, Y; Matsumoto, H; Mikami, K; Suzuki, H; Takaya, A; Yamamoto, K2
Abdel-Mottaleb, MMA; El-Ghany, EA; El-Tokhy, FS; Geneidi, AS1
Choudhury, H; Dalal, R; Gorain, B; Jacob, S; Mehta, TA; Nair, AB; Shah, H; Shah, J1
Hiraoka, S; Iwama, Y; Iwata, N; Kamei, A; Kishi, T; Sasagawa, Y1
Hiraoka, S; Iwama, Y; Kinoshita, T; Takekita, Y; Tamura, F1
Graff-Guerrero, A; Kurose, S; Masuda, F; Mimura, M; Mimura, Y; Miyazaki, T; Nakajima, S; Nishida, H; Noda, Y; Ogyu, K; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M; Yoshida, K1
Barlow, R; Bertrand, S; Cornett, EM; DeGraw, C; Derakhshanian, S; Hasoon, J; Kaye, AD; Kaye, AM; Menard, A; Rath, A; Urits, I; Viswanath, O; Zhou, M1
Citrome, L; Komaroff, M; Kuriki, M; Park, AS; Starling, BR; Terahara, T; Walling, DP; Zeni, CM1
Chen, JM; Chen, JN; Li, Y; Liu, RH; Meng, FL; Meng, TT; Ning, B; Su, GH; Wang, SY; Wu, HH1
Fujiwara, H; Murai, T; Takao, N1
Luck, M; Shad, MU; Turner, M1
Findling, RL; Grant, B; Stepanova, E1
Augusto, M; Greene, M; Sweeney, SM; Touya, M; Waters, H1
Hibino, H; Inoue, Y; Suzuki, H; Takaya, A1
Mishriky, R; Reyad, AA1
Foute Nelong, T; Manduca, JD; Perreault, ML; Zonneveld, PM1
Rasmussen, KG; Swintak, CC; Vande Voort, JL; Wall, CA1
Bressan, RA; Castle, DJ; Cortese, L; Mosolov, SN1
Amrutheshwar, R; Dkhar, SA; George, M; Kattimani, S; Rajkumar, RP1
Alphs, L; Cazorla, P; Phiri, P; Potkin, SG; Szegedi, A; Zhao, J1
Leucht, S; Zhao, J1
Cazorla, P; Kemp, DE; Landbloom, RP; Mackle, M; Snow-Adami, L; Szegedi, A; Zhao, J1
Beauchemin, C; Beillat, M; Gilbert, D; Lachaine, J; Mathurin, K1
Dhillon, R; Kotasek, F; Tibrewal, P1
Citrome, L4
Castle, DJ; Slott Jensen, JK1
Bastiampillai, T; Chen, L; Dhillon, R; Lim, X; Lin, A; Tibrewal, P1
Mandrioli, R; Mercolini, L; Protti, M1
Braat, S; Findling, RL; Hundt, C; Landbloom, RP; Mackle, M; Mathews, M; Pallozzi, W; Wamboldt, MZ1
Hamer, R; McEvoy, J; Sun, X1
Caballero, J; Harrington, CA; Thomas, JE1
Barr, A; Rodriguez, FV; Schultz, K; Wang, L1
Basra, MK; Byers, A; Dutta, S; Hay, A; Sereno, M1
Anugu, RR; Chandrasekhar, S; Mainkar, PS; Sridhar, B1
Boulanger, L; Chitnis, A; Dixit, S; Sun, SX; Tawah, A; Wang, R1
Bhattacharya, A; Bhuyan, D; Ghosh, S; Praharaj, SK1
Bai, YM; Kim, JH; Kinoshita, T; Miyake, M; Oshima, N1
Hundt, C; Kelly, L; Landbloom, R; Mackle, M; Mathews, M; McIntyre, RS; Snow-Adami, L; Wu, X1
de Greef, R; Friberg, LE; Karlsson, MO; Kerbusch, T1
McCormack, PL; Weber, J1
Traynor, K1
Bockbrader, H; Chapel, S; de Greef, R; Haig, G; Hutmacher, MM; Lalonde, RL; Preskorn, SH1
Dritselis, A; Kirkpatrick, P; Meltzer, HY; Yasothan, U1
Shahid, M; Tarazi, FI1
Emsley, R; Naber, D; Panagides, J; Schoemaker, J; Vrijland, P1
Alphs, L; Cohen, M; Kane, JM; Panagides, J; Zhao, J1
Minassian, A; Young, JW1
Bockbrader, H; Chapel, S; de Greef, R; Hutmacher, MM; Lalonde, RL1
de Greef, R; Maloney, A; Olsson-Gisleskog, P; Panagides, J; Schoemaker, J1
Roman, MW1
Kane, JM; Mackle, M; Panagides, J; Snow-Adami, L; Szegedi, A; Zhao, J1
Howland, RH1
Ambrosi, E; Battuello, M; Giordano, G; Girardi, P; Innamorati, M; Lester, D; Pompili, M; Serafini, G; Telesforo, L; Venturini, P1
de Greef, R; Dubovsky, SL; Frobose, C; Panagides, J; Phiri, P1
Fuller, MA; Henry, JM1
McIntyre, RS; Wong, R1
Alphs, L; Buchanan, RW; Cazorla, P; den Hollander, W; Ha, X; Kouassi, A; Panagides, J; Phiri, P; Schooler, N; Szegedi, A; Zhao, J1
Potkin, SG1
Emsley, R; Naber, D; Panagides, J; Schoemaker, J; Stet, L; Vrijland, P1
Pace, HA; Stoner, SC1
Hopkins, CR1
Stahl, SM; Tarazi, FI1
Correll, CU; De Hert, M; Detraux, J; Sweers, K; van Winkel, R; Yu, W1
Neill, JC; Tarazi, FI1
Bobo, WV1
Cazorla, P; Fennema, H; Mackle, M; Szegedi, A; van Duijnhoven, W; Verweij, P1
Alphs, L; Lancaster, S; Panagides, J1
Frånberg, O; Jardemark, K; Konradsson, A; Marcus, MM; Schilström, B; Shahid, M; Svensson, TH; Wiker, C; Wong, EH1
Cohen, M; Panagides, J; Potkin, SG1

Reviews

28 review(s) available for asenapine and Schizophrenia

ArticleYear
Asenapine Transdermal Patch for the Management of Schizophrenia.
    Psychopharmacology bulletin, 2020, 09-14, Volume: 50, Issue:4

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Quality of Life; Schizophrenia; Transdermal Patch

2020
In brief: An asenapine patch (Secuado) for schizophrenia.
    The Medical letter on drugs and therapeutics, 2021, 01-11, Volume: 63, Issue:1615

    Topics: Antipsychotic Agents; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Schizophrenic Psychology; Transdermal Patch

2021
Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review.
    Paediatric drugs, 2018, Volume: 20, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Double-Blind Method; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Treatment Outcome

2018
Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders.
    Psychiatria Danubina, 2019, Volume: 31, Issue:2

    Topics: Antipsychotic Agents; Bipolar Disorder; Borderline Personality Disorder; Dibenzocycloheptenes; Europe; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; United States

2019
Management of schizophrenia: clinical experience with asenapine.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:4 Suppl

    Topics: Antipsychotic Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia

2013
Newer antipsychotics and upcoming molecules for schizophrenia.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:8

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperazines; Piperidines; Schizophrenia; Thiazoles

2013
Early improvement as a predictor of treatment response and remission in patients with schizophrenia: a pooled, post-hoc analysis from the asenapine development program.
    Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:4

    Topics: Antipsychotic Agents; Benzodiazepines; Dibenzocycloheptenes; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Humans; Olanzapine; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Remission Induction; Risperidone; Schizophrenia; Sensitivity and Specificity; Treatment Outcome

2014
Weight change and metabolic effects of asenapine in patients with schizophrenia and bipolar disorder.
    The Journal of clinical psychiatry, 2014, Volume: 75, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Blood Glucose; Body Mass Index; Body Weight; Cholesterol; Cholesterol, LDL; Controlled Clinical Trials as Topic; Dibenzocycloheptenes; Female; Hematologic Tests; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Schizophrenia; Treatment Outcome; Triglycerides; Weight Gain

2014
Asenapine review, part II: clinical efficacy, safety and tolerability.
    Expert opinion on drug safety, 2014, Volume: 13, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Electrocardiography; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2014
Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism.
    Expert opinion on drug metabolism & toxicology, 2014, Volume: 10, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dibenzocycloheptenes; Drug Interactions; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2014
Novel Atypical Antipsychotics: Metabolism and Therapeutic Drug Monitoring (TDM).
    Current drug metabolism, 2015, Volume: 16, Issue:2

    Topics: Animals; Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Drug Design; Drug Monitoring; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; United States; United States Food and Drug Administration

2015
The Incidence of Akathisia in the Treatment of Schizophrenia with Aripiprazole, Asenapine and Lurasidone: A Meta-Analysis.
    Current neuropharmacology, 2015, Volume: 13, Issue:5

    Topics: Akathisia, Drug-Induced; Animals; Antipsychotic Agents; Aripiprazole; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Incidence; Lurasidone Hydrochloride; Schizophrenia

2015
Asenapine versus placebo for schizophrenia.
    The Cochrane database of systematic reviews, 2015, Nov-24, Issue:11

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Psychotic Disorders; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome

2015
Asenapine.
    CNS drugs, 2009, Volume: 23, Issue:9

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2009
Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic.
    International journal of clinical practice, 2009, Volume: 63, Issue:12

    Topics: Administration, Sublingual; Antipsychotic Agents; Bipolar Disorder; Cytochrome P-450 Enzyme System; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome

2009
Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania.
    Drugs of today (Barcelona, Spain : 1998), 2009, Volume: 45, Issue:12

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2009
Asenapine (Saphris) sublingual tablets for schizophrenia and bipolar disorder.
    The Medical letter on drugs and therapeutics, 2010, Feb-08, Volume: 52, Issue:1331

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Controlled Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Weight Gain

2010
Evaluation of the clinical efficacy of asenapine in schizophrenia.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:12

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Dopamine Antagonists; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Serotonin Antagonists; Treatment Outcome

2010
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.
    Postgraduate medicine, 2011, Volume: 123, Issue:2

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles

2011
Unmet treatment needs in schizophrenia patients: is asenapine a potential therapeutic option?
    Expert review of neurotherapeutics, 2011, Volume: 11, Issue:7

    Topics: Antipsychotic Agents; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Medication Adherence; Schizophrenia

2011
Asenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.
    Clinical schizophrenia & related psychoses, 2012, Volume: 5, Issue:4

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Treatment Outcome

2012
Asenapine: a clinical overview.
    The Journal of clinical psychiatry, 2011, Volume: 72 Suppl 1

    Topics: Antipsychotic Agents; Blood Glucose; Dibenzocycloheptenes; Dyslipidemias; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Treatment Outcome; Weight Gain

2011
Asenapine: a clinical review of a second-generation antipsychotic.
    Clinical therapeutics, 2012, Volume: 34, Issue:5

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Psychiatric Status Rating Scales; Schizophrenia; Secondary Prevention

2012
Iloperidone, asenapine and lurasidone: a primer on their current status.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration

2012
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
    CNS drugs, 2012, Sep-01, Volume: 26, Issue:9

    Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain

2012
The preclinical profile of asenapine: clinical relevance for the treatment of schizophrenia and bipolar mania.
    Expert opinion on drug discovery, 2013, Volume: 8, Issue:1

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Humans; Neurotransmitter Agents; Schizophrenia

2013
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.
    Expert review of clinical pharmacology, 2013, Volume: 6, Issue:1

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles

2013
Meta-analyses of the efficacy of asenapine for acute schizophrenia: comparisons with placebo and other antipsychotics.
    The Journal of clinical psychiatry, 2012, Volume: 73, Issue:12

    Topics: Acute Disease; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Psychiatric Status Rating Scales; Psychometrics; Randomized Controlled Trials as Topic; Risk Assessment; Schizophrenia; Schizophrenic Psychology; Treatment Outcome

2012

Trials

19 trial(s) available for asenapine and Schizophrenia

ArticleYear
Asenapine add-on treatment for schizophrenia adults who received antipsychotics: A 52-week, open-label study.
    Psychiatry and clinical neurosciences, 2023, Volume: 77, Issue:6

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Humans; Schizophrenia; Treatment Outcome

2023
Long-term safety and efficacy of sublingual asenapine for the treatment of schizophrenia: A phase III extension study with follow-up for 52 weeks (P06125)-Secondary publication.
    Neuropsychopharmacology reports, 2023, Volume: 43, Issue:3

    Topics: Antipsychotic Agents; Follow-Up Studies; Humans; Schizophrenia

2023
Early improvements of individual symptoms as a predictor of treatment response to asenapine in patients with schizophrenia.
    Neuropsychopharmacology reports, 2020, Volume: 40, Issue:2

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Double-Blind Method; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Schizophrenia; Schizophrenic Psychology; Single-Blind Method; Time Factors; Treatment Outcome

2020
Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study.
    The Journal of clinical psychiatry, 2020, 12-15, Volume: 82, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Dibenzocycloheptenes; Double-Blind Method; Female; Humans; Male; Middle Aged; Schizophrenia; Single-Blind Method; Transdermal Patch; Treatment Outcome

2020
Long-term effects of asenapine or olanzapine in patients with persistent negative symptoms of schizophrenia: a pooled analysis.
    Schizophrenia research, 2013, Volume: 150, Issue:2-3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Databases, Factual; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Longitudinal Studies; Male; Middle Aged; Olanzapine; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome; Young Adult

2013
Management of depressive symptoms in schizophrenia.
    Clinical schizophrenia & related psychoses, 2015, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Depressive Disorder, Major; Dibenzocycloheptenes; Double-Blind Method; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Young Adult

2015
Safety and Efficacy from an 8 Week Double-Blind Trial and a 26 Week Open-Label Extension of Asenapine in Adolescents with Schizophrenia.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Child; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome

2015
Asenapine once daily versus twice daily: impact on patient acceptance in a randomized, open-label, 14-day clinical trial.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:7

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Patient Satisfaction; Schizophrenia; Young Adult

2015
Efficacy and safety of asenapine in Asian patients with an acute exacerbation of schizophrenia: a multicentre, randomized, double-blind, 6-week, placebo-controlled study.
    Psychopharmacology, 2016, Volume: 233, Issue:14

    Topics: Adult; Antipsychotic Agents; Asian People; Body Weight; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Japan; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Republic of Korea; Safety; Schizophrenia; Taiwan; Treatment Outcome

2016
Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control.
    CNS spectrums, 2017, Volume: 22, Issue:4

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Dibenzocycloheptenes; Disease Progression; Disorders of Excessive Somnolence; Dizziness; Double-Blind Method; Dysgeusia; Europe; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Hypesthesia; Least-Squares Analysis; Male; Mouth Diseases; Olanzapine; Schizophrenia; Schizophrenic Psychology; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Weight Gain

2017
Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation.
    Journal of clinical pharmacology, 2009, Volume: 49, Issue:11

    Topics: Adult; Antipsychotic Agents; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Linear Models; Long QT Syndrome; Male; Middle Aged; Schizophrenia; Time Factors

2009
Long-term assessment of Asenapine vs. Olanzapine in patients with schizophrenia or schizoaffective disorder.
    Pharmacopsychiatry, 2010, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Heterocyclic Compounds, 4 or More Rings; Humans; Longitudinal Studies; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Treatment Outcome; Young Adult

2010
Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:2

    Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Dibenzocycloheptenes; Double-Blind Method; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Parkinsonian Disorders; Schizophrenia; Treatment Outcome

2010
Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine.
    Clinical pharmacology and therapeutics, 2011, Volume: 89, Issue:1

    Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Bias; Computer Simulation; Data Interpretation, Statistical; Dibenzocycloheptenes; Dibenzothiazepines; Dose-Response Relationship, Drug; False Positive Reactions; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Biological; Pharmacology, Clinical; Practice Guidelines as Topic; Quetiapine Fumarate; Schizophrenia; Toxicity Tests

2011
A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Anxiety; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Secondary Prevention; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Weight Gain; Young Adult

2011
Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis.
    International journal of geriatric psychiatry, 2012, Volume: 27, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Area Under Curve; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Psychotic Disorders; Schizophrenia

2012
Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:1

    Topics: Adult; Affect; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Dibenzocycloheptenes; Double-Blind Method; Drug Resistance; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Interpersonal Relations; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Psychometrics; Psychomotor Performance; Schizophrenia; Schizophrenic Psychology; Social Behavior; Young Adult

2012
Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study.
    Pharmacopsychiatry, 2012, Volume: 45, Issue:5

    Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Comparative Effectiveness Research; Diagnostic and Statistical Manual of Mental Disorders; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Drug Monitoring; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Longitudinal Studies; Male; Middle Aged; Olanzapine; Pharmacovigilance; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Time; Treatment Outcome; Weight Gain

2012
Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:10

    Topics: Acute Disease; Adult; Antipsychotic Agents; Diagnostic and Statistical Manual of Mental Disorders; Dibenzocycloheptenes; Double-Blind Method; Drug Administration Schedule; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Patient Compliance; Risperidone; Schizophrenia; Severity of Illness Index

2007

Other Studies

30 other study(ies) available for asenapine and Schizophrenia

ArticleYear
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:1

    Topics: Benzodiazepines; Bipolar Disorder; Clinical Trials as Topic; Cloning, Molecular; Clozapine; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Histamine Release; Humans; Inhibitory Concentration 50; Molecular Structure; Olanzapine; Psychotropic Drugs; Radioligand Assay; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Serotonin; Schizophrenia; Substrate Specificity

2009
Continuation rate for asenapine and brexpiprazole treatment in elderly patients with schizophrenia.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2021, Volume: 21, Issue:6

    Topics: Aged; Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Schizophrenia; Thiophenes

2021
Design of long acting invasomal nanovesicles for improved transdermal permeation and bioavailability of asenapine maleate for the chronic treatment of schizophrenia.
    International journal of pharmaceutics, 2021, Oct-25, Volume: 608

    Topics: Administration, Cutaneous; Animals; Biological Availability; Dibenzocycloheptenes; Drug Delivery Systems; Female; Particle Size; Rats; Rats, Wistar; Schizophrenia; Skin

2021
Development and Optimization of Asenapine Sublingual Film Using QbD Approach.
    AAPS PharmSciTech, 2021, Oct-04, Volume: 22, Issue:7

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2021
Continuation rate for asenapine and brexpiprazole treatment in patients with schizophrenia.
    Brain and behavior, 2021, Volume: 11, Issue:5

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Retrospective Studies; Schizophrenia; Thiophenes; Treatment Outcome

2021
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
    Biochemical and biophysical research communications, 2021, 05-14, Volume: 553

    Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Dibenzocycloheptenes; Fibroblasts; Fibrosis; MAP Kinase Signaling System; Myocardium; Rats; Rats, Wistar; Reactive Oxygen Species; Schizophrenia; Transforming Growth Factor beta1

2021
Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine.
    BMJ case reports, 2021, Apr-13, Volume: 14, Issue:4

    Topics: Animals; Antipsychotic Agents; Dibenzocycloheptenes; Dopamine; Heterocyclic Compounds, 4 or More Rings; Humans; Psychotic Disorders; Retrospective Studies; Schizophrenia

2021
Effectiveness of genetically-guided treatment in first-episode schizophrenia.
    Schizophrenia research, 2018, Volume: 193

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Pharmacogenetics; Schizophrenia; Young Adult

2018
Budget impact analysis of long-acting injectable aripiprazole once-monthly 400 mg in bipolar I disorder in the USA.
    Journal of comparative effectiveness research, 2018, Volume: 7, Issue:7

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Budgets; Cost-Benefit Analysis; Delayed-Action Preparations; Dibenzocycloheptenes; Drug Administration Schedule; Drug Costs; Health Care Costs; Heterocyclic Compounds, 4 or More Rings; Hospitalization; Humans; Injections, Intramuscular; Injections, Subcutaneous; Medication Adherence; Paliperidone Palmitate; Piperazines; Schizophrenia

2018
Mortality rate is associated with aripiprazole once-monthly and oral asenapine administration.
    Asian journal of psychiatry, 2019, Volume: 39

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Delayed-Action Preparations; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Japan; Male; Middle Aged; Retrospective Studies; Schizophrenia; Suicide

2019
Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia.
    Neuroscience letters, 2019, 10-15, Volume: 711

    Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Delta Rhythm; Dibenzocycloheptenes; Disease Models, Animal; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Rats; Rats, Sprague-Dawley; Schizophrenia

2019
Methohexital-induced seizures during electroconvulsive therapy.
    The journal of ECT, 2013, Volume: 29, Issue:1

    Topics: Adolescent; Anesthesia; Anesthetics, Intravenous; Antipsychotic Agents; Depressive Disorder, Major; Dibenzocycloheptenes; Electroconvulsive Therapy; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Methohexital; Schizophrenia; Seizures; Social Behavior

2013
Cost-effectiveness of asenapine in the treatment of schizophrenia in Canada.
    Journal of medical economics, 2014, Volume: 17, Issue:4

    Topics: Antipsychotic Agents; Canada; Cost-Benefit Analysis; Decision Trees; Dibenzocycloheptenes; Health Services; Heterocyclic Compounds, 4 or More Rings; Humans; Markov Chains; Models, Economic; Schizophrenia

2014
QTc prolongation with asenapine.
    The Australian and New Zealand journal of psychiatry, 2014, Volume: 48, Issue:10

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Long QT Syndrome; Male; Middle Aged; Schizophrenia

2014
Can asenapine cause myocarditis?
    Asian journal of psychiatry, 2015, Volume: 14

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Edema; Female; Gastrointestinal Diseases; Heterocyclic Compounds, 4 or More Rings; Humans; Middle Aged; Myocarditis; Schizophrenia

2015
A case of pseudo-Stauffer's syndrome related to asenapine use.
    Schizophrenia research, 2015, Volume: 169, Issue:1-3

    Topics: Alkaline Phosphatase; Antipsychotic Agents; Dibenzocycloheptenes; gamma-Glutamyltransferase; Heterocyclic Compounds, 4 or More Rings; Humans; Liver Diseases; Male; Middle Aged; Paraneoplastic Syndromes; Schizophrenia

2015
The Ireland-Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine.
    Organic & biomolecular chemistry, 2016, Jan-28, Volume: 14, Issue:4

    Topics: Antipsychotic Agents; Crystallography, X-Ray; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Molecular; Molecular Structure; Schizophrenia; Stereoisomerism

2016
Changes in Patterns of Utilization and Cost of Health Care Services Associated With Initiation of Asenapine for the Treatment of Schizophrenia in Adults.
    Managed care (Langhorne, Pa.), 2015, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Databases, Factual; Dibenzocycloheptenes; Female; Health Services; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Retrospective Studies; Schizophrenia; Young Adult

2015
Asenapine-Induced Acute Dystonia in an Adolescent Male.
    Journal of child and adolescent psychopharmacology, 2016, Volume: 26, Issue:10

    Topics: Acute Disease; Administration, Sublingual; Adolescent; Antipsychotic Agents; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Dystonia; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Schizophrenia

2016
Modeling and simulation of the time course of asenapine exposure response and dropout patterns in acute schizophrenia.
    Clinical pharmacology and therapeutics, 2009, Volume: 86, Issue:1

    Topics: Acute Disease; Computer Simulation; Controlled Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Biological; Patient Dropouts; Schizophrenia; Schizophrenic Psychology; Time Factors

2009
Asenapine approved for treatment of schizophrenia, bipolar disorder.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Sep-15, Volume: 66, Issue:18

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; United States; United States Food and Drug Administration

2009
Asenapine.
    Nature reviews. Drug discovery, 2009, Volume: 8, Issue:11

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia; United States; United States Food and Drug Administration

2009
New drug information. Saphris.
    JAAPA : official journal of the American Academy of Physician Assistants, 2010, Volume: 23, Issue:3

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Interactions; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2010
Dopamine D2 occupancy as a biomarker for antipsychotics: quantifying the relationship with efficacy and extrapyramidal symptoms.
    The AAPS journal, 2011, Volume: 13, Issue:1

    Topics: Algorithms; Antipsychotic Agents; Basal Ganglia Diseases; Biological Availability; Biomarkers; Computer Simulation; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Endpoint Determination; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Statistical; Positron-Emission Tomography; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Tomography, Emission-Computed, Single-Photon

2011
Atypical antipsychotics: the two new arrivals.
    Issues in mental health nursing, 2011, Volume: 32, Issue:1

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Piperidines; Safety; Schizophrenia; Treatment Outcome; United States; United States Food and Drug Administration

2011
Update on newer antipsychotic drugs.
    Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome

2011
Asenapine: a new antipsychotic option.
    Journal of pharmacy practice, 2011, Volume: 24, Issue:5

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia

2011
ACS chemical neuroscience molecule spotlight on Saphris.
    ACS chemical neuroscience, 2010, Apr-21, Volume: 1, Issue:4

    Topics: Administration, Sublingual; Akathisia, Drug-Induced; Antipsychotic Agents; Biological Availability; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Receptors, Neurotransmitter; Schizophrenia

2010
Asenapine in the treatment of negative symptoms of schizophrenia: clinical trial design and rationale.
    Psychopharmacology bulletin, 2007, Volume: 40, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clinical Trials, Phase III as Topic; Depressive Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Endpoint Determination; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Multicenter Studies as Topic; Neurologic Examination; Olanzapine; Patient Selection; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Research Design; Schizophrenia; Schizophrenic Psychology; Treatment Outcome

2007
Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia.
    Psychopharmacology, 2008, Volume: 196, Issue:3

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Conditioning, Classical; Dibenzocycloheptenes; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Heterocyclic Compounds, 4 or More Rings; Injections, Subcutaneous; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia

2008