Page last updated: 2024-09-04

asenapine and Bipolar Disorder

asenapine has been researched along with Bipolar Disorder in 81 studies

*Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. [MeSH]

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (9.88)29.6817
2010's69 (85.19)24.3611
2020's4 (4.94)2.80

Authors

AuthorsStudies
Shahid, M; Walker, GB; Wong, EH; Zorn, SH1
Choudhury, H; Dalal, R; Gorain, B; Jacob, S; Mehta, TA; Nair, AB; Shah, H; Shah, J1
Adler, C; Ahmad, SC; El-Mallakh, RS; Gao, D; Gao, Y; Nuss, S; Schrodt, C1
Arnt, J; Bundgaard, C; Cope, ZA; Geyer, MA; Kenton, JA; Martin, MV; Minassian, A; Perry, W; van Enkhuizen, J; Young, JW1
Kotak, V; Patel, M; Patel, R; Tanna, N1
Altamura, AC; Buoli, M; Caldiroli, A; Esposito, CM; Godio, M; Serati, M1
Durgam, S; Landbloom, RP; Mackle, M; Mathews, M; Szegedi, A; Wu, X; Yu, SY1
Collins, N; Sager, J1
Montes, JM; Vieta, E1
Findling, RL; Grant, B; Stepanova, E1
Aguglia, A; Aguglia, E; Mineo, L; Rodolico, A; Signorelli, MS1
Einat, H; Stukalin, Y1
Morrens, M; Morsel, AM; Sabbe, B1
Augusto, M; Greene, M; Sweeney, SM; Touya, M; Waters, H1
Gıll, JS; Sulaıman, AH1
Dell'Osso, L; Falaschi, V; Marazziti, D; Mucci, F1
Mishriky, R; Reyad, AA1
McIntyre, RS; Szegedi, A; Zhao, J1
Altamura, AC; González-Pinto, AM; Millet, B; Wiedemann, K; Young, AH1
Dagan, Y; Katz, G1
Berk, M; McIntyre, RS; Tohen, M; Weiller, E; Zhao, J1
De Peri, L; Sacchetti, E; Siracusano, A; Vita, A1
Pitchot, W1
Guiraud-Diawara, A; Michalak, EE; Sapin, C1
Beauchemin, C; Beillat, M; Gilbert, D; Lachaine, J; Mathurin, K1
Cazorla, P; Kemp, DE; Landbloom, RP; Mackle, M; Snow-Adami, L; Szegedi, A; Zhao, J1
Chennoufi, L; Cheour, M; Ouanes, S1
Azorin, JM; Chang, S; Guiraud-Diawara, A; Hansen, K; Marre, C; Rinciog, C; Sawyer, L1
Citrome, L3
Caresano, C; Di Sciascio, G; Fagiolini, A; Maina, G; Perugi, G; Ripellino, C; Vampini, C1
Altamura, AC; Cattaneo, A; Cremaschi, L; Dell'Osso, B; Grancini, B; Maggi, M; Palazzo, MC; Spagnolin, G1
Athey, M; Cassidy, KA; Clegg, K; Dines, P; Fuentes-Casiano, E; Locala, J; Sajatovic, M; Sams, J; Stagno, S; Tatsuoka, C1
El-Mallakh, RS; Worthington, MA1
Einat, H; Ene, HM; Kara, NZ1
Berk, M; Malhi, GS; Tiller, JW; Weiller, E; Yatham, LN; Zhao, J1
Forcada, I; Grande, I; Hidalgo-Mazzei, D; Mur, M; Nieto, E; Sàez, C; Vieta, E1
Gill, JS; Jambunathan, S; Wong, A; Wong, S1
Boulanger, L; Chitnis, A; Dixit, S; Sun, SX; Tawah, A; Wang, R1
Castelnovo, A; Cavallotti, S; D'Agostino, A; Gambini, O; Guanella, E; Ostinelli, EG1
Hundt, C; Kelly, L; Landbloom, RL; Mackle, M; Mathews, M; McIntyre, RS; Snow-Adami, L; Wu, X1
Pirnie, LF; Puttichanda, SP; Ridout, KK; Ridout, SJ1
Braat, S; Chang, K; Findling, RL; Koppenhaver, J; Landbloom, RL; Mackle, M; Mathews, M; Szegedi, A; Zhu, Q1
Kanagasundram, S; Lim, CH; Mohamed, Z; Zain, SM; Zainal, NZ1
Chang, K; Durgam, S; Findling, RL; Landbloom, RL; Mackle, M; Snow-Adami, L; Wu, X1
Durgam, S; Ketter, TA; Landbloom, R; Mackle, M; Mathews, M; Wu, X1
Ding, X; Fitz, M; Maharaj, V1
McCormack, PL; Weber, J1
Traynor, K1
Alphs, L; Cohen, M; Macek, TA; McIntyre, RS; Panagides, J; Zhao, J4
Dritselis, A; Kirkpatrick, P; Meltzer, HY; Yasothan, U1
Shahid, M; Tarazi, FI1
McIntyre, RS2
Roman, MW1
Chwieduk, CM; Scott, LJ1
Howland, RH1
Mackle, M; Nations, KR; Panagides, J; Szegedi, A; van Willigenburg, A; Zhao, J1
Juckel, G1
Gordon, PJ1
Fuller, MA; Henry, JM1
McIntyre, RS; Wong, R1
Calabrese, JR; Mackle, M; Panagides, J; Stet, L; Szegedi, A; Zhao, J1
Pace, HA; Stoner, SC1
Llorca, PM; Samalin, L; Tixeront, C1
Hopkins, CR1
Stahl, SM; Tarazi, FI1
Azorin, JM; Sapin, C; Weiller, E1
Barak, Y; Baruch, Y; Plopski, I; Tadger, S1
Correll, CU; De Hert, M; Detraux, J; Sweers, K; van Winkel, R; Yu, W1
Neill, JC; Tarazi, FI1
Bossini, L; Casamassima, F; Cuomo, A; Fagiolini, A; Forgione, RN; Goracci, A; Maccari, M; Morana, B; Pellegrini, F1

Reviews

28 review(s) available for asenapine and Bipolar Disorder

ArticleYear
Determination of Asenapine Maleate in Pharmaceutical and Biological Matrices: A Critical Review of Analytical Techniques over the Past Decade.
    Critical reviews in analytical chemistry, 2022, Volume: 52, Issue:8

    Topics: Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Pharmaceutical Preparations

2022
A Review of Asenapine in the Treatment of Bipolar Disorder.
    Clinical drug investigation, 2018, Volume: 38, Issue:2

    Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Dizziness; Heterocyclic Compounds, 4 or More Rings; Humans; Olanzapine; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome; Weight Gain

2018
Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review.
    Paediatric drugs, 2018, Volume: 20, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Double-Blind Method; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Treatment Outcome

2018
An overview of pharmacotherapy for bipolar I disorder.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:3

    Topics: Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Therapy, Combination; Evidence-Based Practice; Heterocyclic Compounds, 4 or More Rings; Humans; Lithium; Tamoxifen

2018
Asenapine for the treatment of bipolar disorder.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:11

    Topics: Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Dizziness; Half-Life; Heterocyclic Compounds, 4 or More Rings; Humans

2019
Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders.
    Psychiatria Danubina, 2019, Volume: 31, Issue:2

    Topics: Antipsychotic Agents; Bipolar Disorder; Borderline Personality Disorder; Dibenzocycloheptenes; Europe; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; United States

2019
Use of asenapine in clinical practice for the management of bipolar mania.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:4 Suppl

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Randomized Controlled Trials as Topic; Treatment Outcome

2013
Efficacy and tolerability of asenapine for acute mania in bipolar I disorder: meta-analyses of randomized-controlled trials.
    International clinical psychopharmacology, 2013, Volume: 28, Issue:5

    Topics: Acute Disease; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic

2013
Weight change and metabolic effects of asenapine in patients with schizophrenia and bipolar disorder.
    The Journal of clinical psychiatry, 2014, Volume: 75, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Blood Glucose; Body Mass Index; Body Weight; Cholesterol; Cholesterol, LDL; Controlled Clinical Trials as Topic; Dibenzocycloheptenes; Female; Hematologic Tests; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Schizophrenia; Treatment Outcome; Triglycerides; Weight Gain

2014
An update on the treatment of mixed bipolar states: what is new in 2013?
    Journal of affective disorders, 2014, Volume: 158

    Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bipolar Disorder; Calcitonin; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Olanzapine; Piperazines; Quinolones; Randomized Controlled Trials as Topic; Thiazoles; Treatment Outcome

2014
Asenapine review, part II: clinical efficacy, safety and tolerability.
    Expert opinion on drug safety, 2014, Volume: 13, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Electrocardiography; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2014
Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism.
    Expert opinion on drug metabolism & toxicology, 2014, Volume: 10, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dibenzocycloheptenes; Drug Interactions; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2014
Use of asenapine as add-on therapy in the treatment of bipolar disorder: a comprehensive review and case series.
    Expert opinion on drug safety, 2014, Volume: 13, Issue:9

    Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Therapy, Combination; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Middle Aged; Randomized Controlled Trials as Topic; Time Factors

2014
Asenapine.
    CNS drugs, 2009, Volume: 23, Issue:9

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2009
Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic.
    International journal of clinical practice, 2009, Volume: 63, Issue:12

    Topics: Administration, Sublingual; Antipsychotic Agents; Bipolar Disorder; Cytochrome P-450 Enzyme System; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome

2009
Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania.
    Drugs of today (Barcelona, Spain : 1998), 2009, Volume: 45, Issue:12

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2009
Asenapine (Saphris) sublingual tablets for schizophrenia and bipolar disorder.
    The Medical letter on drugs and therapeutics, 2010, Feb-08, Volume: 52, Issue:1331

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Controlled Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Weight Gain

2010
Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder.
    Expert review of neurotherapeutics, 2010, Volume: 10, Issue:5

    Topics: Administration, Sublingual; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Evaluation; Heterocyclic Compounds, 4 or More Rings; Humans; PubMed

2010
Asenapine: a review of acute and extension phase data in bipolar disorder.
    CNS neuroscience & therapeutics, 2011, Volume: 17, Issue:6

    Topics: Acute Disease; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Double-Blind Method; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Receptors, Serotonin

2011
Asenapine: a review of its use in the management of mania in adults with bipolar I disorder.
    CNS drugs, 2011, Volume: 25, Issue:3

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Olanzapine; Psychiatric Status Rating Scales

2011
Asenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.
    Clinical schizophrenia & related psychoses, 2012, Volume: 5, Issue:4

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; Treatment Outcome

2012
Asenapine: a clinical review of a second-generation antipsychotic.
    Clinical therapeutics, 2012, Volume: 34, Issue:5

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Psychiatric Status Rating Scales; Schizophrenia; Secondary Prevention

2012
[Asenapine in bipolar disorder: efficacy, safety and place in clinical practice].
    L'Encephale, 2012, Volume: 38, Issue:3

    Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Double-Blind Method; Drug Therapy, Combination; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Olanzapine; Psychiatric Status Rating Scales; Psychometrics; Randomized Controlled Trials as Topic; Treatment Outcome

2012
Iloperidone, asenapine and lurasidone: a primer on their current status.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration

2012
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
    CNS drugs, 2012, Sep-01, Volume: 26, Issue:9

    Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain

2012
The preclinical profile of asenapine: clinical relevance for the treatment of schizophrenia and bipolar mania.
    Expert opinion on drug discovery, 2013, Volume: 8, Issue:1

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Humans; Neurotransmitter Agents; Schizophrenia

2013
Asenapine: a less effective, yet, more dangerous neuroleptic!
    Prescrire international, 2012, Volume: 21, Issue:131

    Topics: Administration, Sublingual; Affect; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Patient Safety; Research Design; Risk Assessment; Risk Factors; Treatment Outcome

2012
Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice.
    Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:4

    Topics: Administration, Sublingual; Antipsychotic Agents; Biological Availability; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Metabolic Clearance Rate; Weight Gain

2013

Trials

16 trial(s) available for asenapine and Bipolar Disorder

ArticleYear
Asenapine in the Treatment of Bipolar Depression.
    Psychopharmacology bulletin, 2020, 03-12, Volume: 50, Issue:1

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Double-Blind Method; Humans; Psychiatric Status Rating Scales; Treatment Outcome

2020
Have antipsychotics a different speed of action in the acute treatment of mania? A single-blind comparative study.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Single-Blind Method; Time Factors; Treatment Outcome

2017
Randomized, Double-Blind, Placebo-Controlled Trial of Asenapine Maintenance Therapy in Adults With an Acute Manic or Mixed Episode Associated With Bipolar I Disorder.
    The American journal of psychiatry, 2018, 01-01, Volume: 175, Issue:1

    Topics: Adult; Affect; Antipsychotic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Kaplan-Meier Estimate; Male; Patient Acuity; Psychiatric Status Rating Scales; Time; Treatment Outcome

2018
Early improvement as a predictor of acute treatment outcome in manic or mixed episodes in bipolar-1 disorder: a pooled, post hoc analysis from the asenapine development program.
    Journal of affective disorders, 2013, Sep-25, Volume: 150, Issue:3

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult

2013
Asenapine treatment and health-related quality of life in patients experiencing bipolar I disorder with mixed episodes: post-hoc analyses of pivotal trials.
    Current medical research and opinion, 2014, Volume: 30, Issue:4

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Quality of Life

2014
Asenapine: Efficacy and safety of 5 and 10mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder.
    Journal of affective disorders, 2016, Jan-15, Volume: 190

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Treatment Outcome; Young Adult

2016
Asenapine for the Acute Treatment of Pediatric Manic or Mixed Episode of Bipolar I Disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2015, Volume: 54, Issue:12

    Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Child; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Logistic Models; Male; Psychiatric Status Rating Scales; Russia; United States

2015
Long-term Safety of Asenapine in Pediatric Patients Diagnosed With Bipolar I Disorder: A 50-Week Open-Label, Flexible-Dose Trial.
    Paediatric drugs, 2016, Volume: 18, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Child; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Psychiatric Status Rating Scales; Russia; United States; United States Food and Drug Administration

2016
Long-term safety and tolerability of asenapine: A double-blind, uncontrolled, long-term extension trial in adults with an acute manic or mixed episode associated with bipolar I disorder.
    Journal of affective disorders, 2017, Jan-01, Volume: 207

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Psychiatric Status Rating Scales; Treatment Outcome

2017
Asenapine versus olanzapine in acute mania: a double-blind extension study.
    Bipolar disorders, 2009, Volume: 11, Issue:8

    Topics: Acute Disease; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Heterocyclic Compounds, 4 or More Rings; Humans; International Cooperation; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult

2009
A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states.
    Bipolar disorders, 2009, Volume: 11, Issue:7

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Body Weight; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Models, Statistical; Olanzapine; Patient Compliance; Psychiatric Status Rating Scales; Single-Blind Method; Time Factors; Treatment Outcome; Young Adult

2009
Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial.
    Journal of affective disorders, 2010, Volume: 122, Issue:1-2

    Topics: Acute Disease; Administration, Sublingual; Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Psychometrics; Young Adult

2010
Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study.
    Journal of affective disorders, 2010, Volume: 126, Issue:3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Long-Term Care; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Psychometrics; Young Adult

2010
Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials.
    BMC psychiatry, 2011, Jun-20, Volume: 11

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Depression; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Olanzapine; Psychiatric Status Rating Scales; Severity of Illness Index

2011
Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:1

    Topics: Acute Disease; Adult; Affect; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Lithium Carbonate; Male; Middle Aged; Psychiatric Status Rating Scales; Valproic Acid; Young Adult

2012
Asenapine for elderly bipolar manic patients.
    Journal of affective disorders, 2013, Feb-15, Volume: 145, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Psychiatric Status Rating Scales

2013

Other Studies

37 other study(ies) available for asenapine and Bipolar Disorder

ArticleYear
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:1

    Topics: Benzodiazepines; Bipolar Disorder; Clinical Trials as Topic; Cloning, Molecular; Clozapine; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Histamine Release; Humans; Inhibitory Concentration 50; Molecular Structure; Olanzapine; Psychotropic Drugs; Radioligand Assay; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Serotonin; Schizophrenia; Substrate Specificity

2009
Development and Optimization of Asenapine Sublingual Film Using QbD Approach.
    AAPS PharmSciTech, 2021, Oct-04, Volume: 22, Issue:7

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2021
Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice.
    Behavioural brain research, 2021, 05-07, Volume: 405

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bipolar Disorder; Dibenzocycloheptenes; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Female; Male; Mania; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Risperidone

2021
Acute Laryngeal Dystonia Associated With Asenapine Use: A Case Report.
    Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Dystonia; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Laryngeal Diseases; Middle Aged

2017
Asenapine in the management of impulsivity and aggressiveness in bipolar disorder and comorbid borderline personality disorder: an open-label uncontrolled study.
    International clinical psychopharmacology, 2018, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Aged; Aggression; Antipsychotic Agents; Bipolar Disorder; Borderline Personality Disorder; Comorbidity; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Hostility; Humans; Impulsive Behavior; Middle Aged; Psychiatric Status Rating Scales; Surveys and Questionnaires; Young Adult

2018
Analyzing test batteries in animal models of psychopathology with multivariate analysis of variance (MANOVA): One possible approach to increase external validity.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 178

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antimanic Agents; Anxiety; Behavior Rating Scale; Behavior, Animal; Bipolar Disorder; Dibenzocycloheptenes; Disease Models, Animal; Female; Heterocyclic Compounds, 4 or More Rings; Lithium; Luria-Nebraska Neuropsychological Battery; Male; Mice; Multivariate Analysis; Psychopathology; Reproducibility of Results; Sex Factors

2019
Budget impact analysis of long-acting injectable aripiprazole once-monthly 400 mg in bipolar I disorder in the USA.
    Journal of comparative effectiveness research, 2018, Volume: 7, Issue:7

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Budgets; Cost-Benefit Analysis; Delayed-Action Preparations; Dibenzocycloheptenes; Drug Administration Schedule; Drug Costs; Health Care Costs; Heterocyclic Compounds, 4 or More Rings; Hospitalization; Humans; Injections, Intramuscular; Injections, Subcutaneous; Medication Adherence; Paliperidone Palmitate; Piperazines; Schizophrenia

2018
QTc Prolongation and Ventricular Trigemini with Asenapine: A Case Report.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2018,Spring, Volume: 29, Issue:1

    Topics: Aged; Antipsychotic Agents; Bipolar Disorder; Diagnosis, Differential; Dibenzocycloheptenes; Electrocardiography; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Long QT Syndrome

2018
A case of atypical antipsychotic-induced somnambulism: a class effect.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:4

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dibenzocycloheptenes; Dibenzothiazepines; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Olanzapine; Quetiapine Fumarate; Somnambulism

2013
DSM-5 mixed specifier for manic episodes: evaluating the effect of depressive features on severity and treatment outcome using asenapine clinical trial data.
    Journal of affective disorders, 2013, Sep-05, Volume: 150, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Depression; Diagnostic and Statistical Manual of Mental Disorders; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Olanzapine; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome

2013
[Medication of the month. asenapine (Sycrest].
    Revue medicale de Liege, 2013, Volume: 68, Issue:4

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans

2013
Cost-effectiveness of asenapine in the treatment of bipolar disorder in Canada.
    BMC psychiatry, 2014, Jan-22, Volume: 14

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Canada; Cost-Benefit Analysis; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Olanzapine; Quality-Adjusted Life Years; Weight Gain

2014
Cost-effectiveness of asenapine in the treatment of bipolar I disorder patients with mixed episodes.
    Journal of medical economics, 2014, Volume: 17, Issue:7

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clinical Trials as Topic; Cost-Benefit Analysis; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Markov Chains; Models, Economic; Olanzapine; Quality-Adjusted Life Years; State Medicine; United Kingdom; Weight Gain

2014
Cost-effectiveness of asenapine in the treatment of patients with bipolar I disorder with mixed episodes in an Italian context.
    Advances in therapy, 2014, Volume: 31, Issue:8

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Cost-Benefit Analysis; Dibenzocycloheptenes; Health Services; Heterocyclic Compounds, 4 or More Rings; Humans; Italy; Models, Econometric; Olanzapine; Quality of Life; Quality-Adjusted Life Years; Reproducibility of Results

2014
Asenapine in the treatment of older adults with bipolar disorder.
    International journal of geriatric psychiatry, 2015, Volume: 30, Issue:7

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Patient Satisfaction; Prospective Studies; Psychiatric Status Rating Scales

2015
A naturalistic retrospective review of weight gain in bipolar patients treated with second generation antipsychotics.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:2

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Body Weight; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Retrospective Studies; Weight Gain

2015
The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors.
    Behavioural pharmacology, 2015, Volume: 26, Issue:4

    Topics: Akathisia, Drug-Induced; Amphetamine; Anhedonia; Animals; Antimanic Agents; Antipsychotic Agents; Appetitive Behavior; Bipolar Disorder; Central Nervous System Stimulants; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Exploratory Behavior; Food Preferences; Heterocyclic Compounds, 4 or More Rings; Male; Mice; Models, Animal; Motor Activity; Neuropsychological Tests; Saccharin; Social Behavior

2015
Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Depressive Disorder, Major; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Multicenter Studies as Topic; Olanzapine; Randomized Controlled Trials as Topic; Retrospective Studies; Treatment Outcome; Young Adult

2015
Asenapine prescribing patterns in the treatment of manic in- and outpatients: Results from the MANACOR study.
    European psychiatry : the journal of the Association of European Psychiatrists, 2015, Volume: 30, Issue:4

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Depression; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Outpatients; Personality Disorders; Prospective Studies; Psychotic Disorders; Retrospective Studies; Treatment Outcome

2015
Paradoxical pinpoint pupils with asenapine.
    Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2015, Volume: 7, Issue:2

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Miosis; Pupil

2015
Impact of initiation of asenapine on patterns of utilization and cost of healthcare resources associated with the treatment of bipolar I disorder.
    Journal of medical economics, 2015, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Bipolar Disorder; Comorbidity; Dibenzocycloheptenes; Fees, Pharmaceutical; Female; Health Services; Heterocyclic Compounds, 4 or More Rings; Hospitalization; Humans; Insurance Claim Review; Male; Middle Aged; Retrospective Studies; United States; Young Adult

2015
Asenapine in the Treatment of Acute Mania: A Real-World Observational Study With 6 Months Follow-Up.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:5

    Topics: Acute Disease; Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Female; Follow-Up Studies; Heterocyclic Compounds, 4 or More Rings; Hospitalization; Humans; Length of Stay; Male; Middle Aged; Patient Readmission; Psychiatric Status Rating Scales; Psychotic Disorders

2015
Sudden-onset dystonia in a patient taking asenapine: interaction between ciprofloxacin and asenapine metabolism.
    The American journal of psychiatry, 2015, Nov-01, Volume: 172, Issue:11

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Ciprofloxacin; Cytochrome P-450 CYP1A2 Inhibitors; Dibenzocycloheptenes; Drug Interactions; Dystonia; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Urinary Tract Infections

2015
Preliminary examination of microRNA expression profiling in bipolar disorder I patients during antipsychotic treatment.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016, Volume: 171, Issue:6

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Female; Gene Expression Profiling; Heterocyclic Compounds, 4 or More Rings; Humans; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Risperidone; Transcriptome

2016
Drug-Induced Liver Injury in the Setting of Glycogenic Hepatopathy.
    Journal of general internal medicine, 2017, Volume: 32, Issue:6

    Topics: Abdominal Pain; Antipsychotic Agents; Biopsy; Bipolar Disorder; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Diagnosis, Differential; Dibenzocycloheptenes; Female; Glycogen; Hepatomegaly; Heterocyclic Compounds, 4 or More Rings; Humans; Liver; Magnetic Resonance Imaging; Young Adult

2017
Asenapine approved for treatment of schizophrenia, bipolar disorder.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Sep-15, Volume: 66, Issue:18

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia; United States; United States Food and Drug Administration

2009
Asenapine.
    Nature reviews. Drug discovery, 2009, Volume: 8, Issue:11

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia; United States; United States Food and Drug Administration

2009
New drug information. Saphris.
    JAAPA : official journal of the American Academy of Physician Assistants, 2010, Volume: 23, Issue:3

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Interactions; Heterocyclic Compounds, 4 or More Rings; Humans; Schizophrenia

2010
Atypical antipsychotics: the two new arrivals.
    Issues in mental health nursing, 2011, Volume: 32, Issue:1

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Piperidines; Safety; Schizophrenia; Treatment Outcome; United States; United States Food and Drug Administration

2011
Update on newer antipsychotic drugs.
    Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome

2011
[Antipsychotic medications for bipolar I disorders. New atypical neuroleptic drug asenapine approved].
    Der Nervenarzt, 2012, Volume: 83, Issue:3

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Germany; Heterocyclic Compounds, 4 or More Rings; Humans

2012
System for disclosing hospitality should be transparent.
    BMJ (Clinical research ed.), 2011, Nov-15, Volume: 343

    Topics: Advertising; Antipsychotic Agents; Bipolar Disorder; Congresses as Topic; Dibenzocycloheptenes; Drug Industry; Education, Medical, Continuing; Heterocyclic Compounds, 4 or More Rings; Humans

2011
Asenapine: a new antipsychotic option.
    Journal of pharmacy practice, 2011, Volume: 24, Issue:5

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Randomized Controlled Trials as Topic; Schizophrenia

2011
▼Asenapine for bipolar I disorder?
    Drug and therapeutics bulletin, 2012, Volume: 50, Issue:6

    Topics: Administration, Sublingual; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Drug Interactions; Drug Overdose; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Meta-Analysis as Topic; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Treatment Outcome

2012
ACS chemical neuroscience molecule spotlight on Saphris.
    ACS chemical neuroscience, 2010, Apr-21, Volume: 1, Issue:4

    Topics: Administration, Sublingual; Akathisia, Drug-Induced; Antipsychotic Agents; Biological Availability; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Receptors, Neurotransmitter; Schizophrenia

2010
Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses.
    Journal of affective disorders, 2013, Feb-15, Volume: 145, Issue:1

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dibenzocycloheptenes; Double-Blind Method; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic

2013
Common sense.
    Prescrire international, 2012, Volume: 21, Issue:131

    Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans

2012