ascorbic-acid-2-o-glucoside and Rhabdomyosarcoma

The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.

Topics: Antiviral Agents; Ascorbic Acid; Carbon; Cell Line, Tumor; Free Radical Scavengers; Herpesvirus 1, Human; Humans; Oxygen; Radiation, Ionizing; Reactive Oxygen Species; Rhabdomyosarcoma