ascorbic-acid-2-o-glucoside and Ascorbic-Acid-Deficiency

ascorbic-acid-2-o-glucoside has been researched along with Ascorbic-Acid-Deficiency* in 1 studies

Other Studies

1 other study(ies) available for ascorbic-acid-2-o-glucoside and Ascorbic-Acid-Deficiency

ArticleYear
Bioavailability of a series of novel acylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as an ascorbic acid supplement in rats and guinea pigs.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:8

    The bioavailability of a series of novel acylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids (6-Acyl-AA-2G), as an ascorbic acid (AA) supplement was investigated in rats and guinea pigs. Oral administration of 6-Acyl-AA-2G to rats resulted in an increase in the plasma AA level. However, the intact form was not detectable in the plasma by high-performance liquid chromatography, indicating its hydrolysis through the process of absorption. After an intravenous injection to rats of 6-Octa-AA-2G as a representative derivative, the intact form rapidly disappeared from the plasma, being followed by a prolonged and marked elevation of the plasma AA level. Various tissue homogenates from guinea pigs were examined for their releasing activity of AA, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G) and 6-O-acyl-AA from 6-Acyl-AA-2G. High activity was observed in the small intestine. These hydrolytic activities to AA and 6-O-acyl-AA were completely inhibited by castanospermine, an alpha-glucosidase inhibitor, and AA-2G was observed as the only resulting hydrolysate, suggesting the participation of alpha-glucosidase and esterase in the in vivo hydrolysis of 6-Acyl-AA-2G. 6-Octa-AA-2G was found to exhibit an obvious therapeutic effect in scorbutic guinea pigs from its repeated oral administration. These results indicate that 6-Acyl-AA-2G is a readily available source of AA activity in vivo, and may be useful as an effective pharmacological agent and as a promising food additive.

    Topics: alpha-Glucosidases; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biological Availability; Brain; Dietary Supplements; Esterases; Guinea Pigs; Hydrolysis; Intestine, Small; Liver; Male; Rats; Rats, Wistar; Scurvy; Skin

2002