asbestos--crocidolite and Colonic-Neoplasms

asbestos--crocidolite has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for asbestos--crocidolite and Colonic-Neoplasms

Article	Year
Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). Lung cancer (Amsterdam, Netherlands), 2005, Volume: 48, Issue:1 Malignant pleural mesothelioma (MPM) is a fatal neoplasm with no acceptable curative approaches. We used serial analysis of gene expression (SAGE) to compare the gene expression pattern of a surgically resected MPM to the autologous normal mesothelium. Intelectin gene overexpression (>139-fold) was found in the tumor. Online SAGE datasets revealed intelectin to be consistently present in mesothelioma(s), ovarian cancer, and colon cancer. Intelectin mRNA expression was found by RT-PCR in 4 of 5 resected MPM tumors, and Intelectin protein expression was confirmed by immunohistochemistry in 28 of 53 MPM tumors, and in 4 of 4 mesothelioma cell lines studied by Western blot. A marked induction in intelectin gene expression was observed among human primary mesothelial cells as a consequence of crocidolite asbestos exposure and simian virus 40 infection. Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications. Topics: Asbestos, Crocidolite; Blotting, Western; Case-Control Studies; Colonic Neoplasms; Cytokines; Databases, Genetic; Female; Gene Expression Profiling; GPI-Linked Proteins; Humans; Immunohistochemistry; Lectins; Mesothelioma; Ovarian Neoplasms; Pleural Neoplasms; Polyomavirus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Virus Infections	2005
Asbestos induces aberrant crypt foci in the colon of rats. Cancer letters, 1993, Nov-01, Volume: 74, Issue:3 The carcinogenicity of asbestos to the gut is controversial. The aberrant crypt focus (ACF) assay is proposed as a test for colon carcinogens. We have scored ACF in the colon of rats and mice, one month after per os gavages with suspensions of asbestos fibers. Crocidolite asbestos induced ACF in the colon of rats in two independent experiments (P = 0.02 and P < 0.01 compared to controls given water), and was ten times less effective than the carcinogen azoxymethane. Chrysotile asbestos also induced ACF in rats. Neither crocidolite nor chrysotile induced ACF in mice. The data suggest that ingested asbestos may be carcinogenic to the colon. Topics: Animals; Asbestos, Crocidolite; Asbestos, Serpentine; Azoxymethane; Carcinogenicity Tests; Colonic Neoplasms; Female; Mice; Precancerous Conditions; Rats; Rats, Inbred F344	1993

Article

Year

Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).

Lung cancer (Amsterdam, Netherlands), 2005, Volume: 48, Issue:1

Malignant pleural mesothelioma (MPM) is a fatal neoplasm with no acceptable curative approaches. We used serial analysis of gene expression (SAGE) to compare the gene expression pattern of a surgically resected MPM to the autologous normal mesothelium. Intelectin gene overexpression (>139-fold) was found in the tumor. Online SAGE datasets revealed intelectin to be consistently present in mesothelioma(s), ovarian cancer, and colon cancer. Intelectin mRNA expression was found by RT-PCR in 4 of 5 resected MPM tumors, and Intelectin protein expression was confirmed by immunohistochemistry in 28 of 53 MPM tumors, and in 4 of 4 mesothelioma cell lines studied by Western blot. A marked induction in intelectin gene expression was observed among human primary mesothelial cells as a consequence of crocidolite asbestos exposure and simian virus 40 infection. Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications.

Topics: Asbestos, Crocidolite; Blotting, Western; Case-Control Studies; Colonic Neoplasms; Cytokines; Databases, Genetic; Female; Gene Expression Profiling; GPI-Linked Proteins; Humans; Immunohistochemistry; Lectins; Mesothelioma; Ovarian Neoplasms; Pleural Neoplasms; Polyomavirus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Virus Infections

2005

Asbestos induces aberrant crypt foci in the colon of rats.

Cancer letters, 1993, Nov-01, Volume: 74, Issue:3

The carcinogenicity of asbestos to the gut is controversial. The aberrant crypt focus (ACF) assay is proposed as a test for colon carcinogens. We have scored ACF in the colon of rats and mice, one month after per os gavages with suspensions of asbestos fibers. Crocidolite asbestos induced ACF in the colon of rats in two independent experiments (P = 0.02 and P < 0.01 compared to controls given water), and was ten times less effective than the carcinogen azoxymethane. Chrysotile asbestos also induced ACF in rats. Neither crocidolite nor chrysotile induced ACF in mice. The data suggest that ingested asbestos may be carcinogenic to the colon.

Topics: Animals; Asbestos, Crocidolite; Asbestos, Serpentine; Azoxymethane; Carcinogenicity Tests; Colonic Neoplasms; Female; Mice; Precancerous Conditions; Rats; Rats, Inbred F344

1993