as-1411 and Drug-Related-Side-Effects-and-Adverse-Reactions

Small interfering RNAs (siRNA)/microRNAs (miRNA) have promising therapeutic potential, yet their clinical application has been hampered by the lack of appropriate delivery systems. Herein, we employed extracellular vesicles (EVs) as a targeted delivery system for small RNAs. EVs are cell-derived small vesicles that participate in cell-to-cell communication for protein and RNA delivery. We used the aptamer AS1411-modified EVs for targeted delivery of siRNA/microRNA to breast cancer tissues. Tumor targeting was facilitated via AS1411 binding to nucleolin, which is highly expressed on the surface membrane of breast cancer cells. This delivery vesicle targeted let-7 miRNA delivery to MDA-MB-231 cells

Topics: Animals; Antineoplastic Agents; Aptamers, Nucleotide; Biological Products; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug-Related Side Effects and Adverse Reactions; Extracellular Vesicles; Mice; Nucleolin; Oligodeoxyribonucleotides; Phosphoproteins; RNA-Binding Proteins; RNA, Small Untranslated; Treatment Outcome