arugomycin has been researched along with Sarcoma-180* in 2 studies
2 other study(ies) available for arugomycin and Sarcoma-180
| Article | Year |
|---|---|
Arugomycin, a new anthracycline antibiotic. III. Biological activities of arugomycin and its analogues obtained by chemical degradation and modification.
Biological activities of arugomycin and its analogues obtained by chemical degradation and modification were evaluated. Differences in the sugar moieties affected their biological activities including induction of differentiation of mouse Friend erythroleukemia cells and mouse myeloid leukemia cells, antitumor activities against sarcoma S-180, Ehrlich ascites carcinoma and P388 leukemia, and cytotoxicity against murine leukemia cells. Some relationships were found between the sugar moieties and biological activities. Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry, Physical; Leukemia L5178; Leukemia P388; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid, Acute; Magnetic Resonance Spectroscopy; Mice; Naphthacenes; Sarcoma 180 | 1987 |
Arugomycin, a new anthracycline antibiotic. I. Taxonomy, fermentation, isolation and physico-chemical properties.
Arugomycin (AGM) is a new anthracycline antibiotic produced by strain No. 1098-AV2 which was identified as Streptomyces violaceochromogenes. AGM was isolated by solvent extraction, silicic acid chromatography and Sephadex LH-20 column chromatography. Acid treatment of AGM gave the chromophore, named arugorol, which was identified as 4'-epi-nogalarol, and sugar moieties. AGM inhibited the growth of Gram-positive bacteria and showed antitumor activity against sarcoma S-180 and Ehrlich ascites tumors. Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry, Physical; Gram-Positive Bacteria; Lethal Dose 50; Magnetic Resonance Spectroscopy; Mice; Naphthacenes; Sarcoma 180; Streptomyces | 1987 |