artesunic acid has been researched along with Disease Models, Animal in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.20) | 18.2507 |
| 2000's | 11 (13.25) | 29.6817 |
| 2010's | 51 (61.45) | 24.3611 |
| 2020's | 20 (24.10) | 2.80 |
| Authors | Studies |
|---|---|
| Azambuja, JH; Mancuso, RI; Olalla Saad, ST | 1 |
| Arany, E; Bennett, J; Deane, M; Hill, DJ; Strutt, B; Szlapinski, S | 1 |
| Chen, X; Feng, H; Ge, H; Lei, X; Tan, L; Wan, F; Wang, J; Yang, Y; Zhang, K | 1 |
| Fang, Q; Jiang, JH; Liu, MR; Liu, Y; Ma, CQ; Qin, YR; Wang, DP; Zhang, QQ; Zhao, HR | 1 |
| Deng, C; Guo, W; Guo, X; Huang, X; Li, C; Pan, Z; Song, J; Tang, Y; Wang, Q; Wu, Z; Xu, Q; Yuan, Y; Zhang, H; Zou, Y | 1 |
| Galaj, E; Guo, Y; Huang, S; Liu, K; Luo, Y; Meng, L; Shi, H; Shi, M; Wang, J; Wang, S; Yin, X | 1 |
| Gorgas, K; Groeneweg, F; Kins, S; Kirsch, J; Kiss, E; Kuhse, J; Nawrotzki, R | 1 |
| Chen, X; Hua, L; Huang, Y; Liu, D; Liu, X; Long, S; Ouyang, F; Yuan, Y; Zheng, J; Zhou, H; Zhou, J | 1 |
| Darjatmoko, SR; Farnoodian, M; Inampudi, S; Sheibani, N; Song, YS; Sorenson, CM; Wang, S | 1 |
| Chen, L; Chen, S; Li, J; Li, Z; Liu, T; Nong, X; Rajbanshi, G; Wei, G | 1 |
| Dong, H; Jing, W; Jun, X; Min, M; Runpeng, Z; Shuo, L; Yingru, X | 1 |
| Chen, H; Chiu, K; Gao, Q; Qian, X; Qiu, J; Wu, N; Wu, Y; Yang, Y; Zeng, J; Zhuang, J | 1 |
| Han, X; Li, X; Sun, W; Wu, J; Wu, S; Yang, C | 1 |
| Huang, MZ; Ning, X; Shang, XW; Shen, ZM; Zhang, H; Zhuang, Y | 1 |
| Carvalho, LJM; Nugraha, AB; Sivakumar, T; Tuvshintulga, B; Yokoyama, N | 1 |
| Fujii, G; Hamoya, T; Iizumi, Y; Kishimoto, S; Komiya, M; Kondo, T; Matsuzawa, Y; Miki, K; Mutoh, M; Narita, T; Sakai, T; Toshima, J; Wakabayashi, K; Watanabe, K | 1 |
| Chen, MX; Gao, JH; He, LH; Luo, JJ; Qin, YS; Tang, CK; Wang, ZB; Wen, FJ; Yu, XH; Zhang, DW | 1 |
| Ao, L; Deng, F; Fang, Q; Liao, M; Liu, M; Luo, J; Wang, N; Wang, Q; Wang, Y; Zhang, Y; Zhou, H | 1 |
| Fu, J; Shao, Y; Shi, H; Wang, B; Ye, L; Zhan, T; Zheng, L | 1 |
| Gille, L; Machín, L; Monzote, L; Nápoles, R | 1 |
| Bang, S; Bortsov, AV; Chandra, S; Derbyshire, ER; Donnelly, CR; Ji, RR; Luo, X; Tao, X; Toro-Moreno, M; Wang, Z | 1 |
| Lu, J; Pan, K; Song, Y | 1 |
| Cai, L; Ding, Y; Li, X; Shi, Z; Tang, H; Zhou, M | 1 |
| Ateeq, B; Goel, S; Nunes, JJ; Pandey, SK; Yadav, A | 1 |
| Cao, Y; Chen, G; Cui, L; Du, Y; Yu, C; Zhang, X | 1 |
| Chang, ZW; Claser, C; Rénia, L; Russell, B | 1 |
| Kimani, FT; Kirira, PG; Magoma, GN; Malala, BJ; Muregi, FW; Odhiambo, OC; Wamakima, HN | 1 |
| Besla, R; Davies, M; Elphinstone, RE; Hausladen, A; Husain, M; Kain, KC; Lu, Z; Robbins, CS; Shikatani, EA; Stamler, JS | 1 |
| Feng, FB; Qiu, HY | 1 |
| Chen, J; Collino, M; Decosterd, L; Kapoor, A; Khan, AI; Martin, L; Mercier, T; Rogazzo, M; Thiemermann, C | 1 |
| Feng, Y; Gao, H; Kang, N; Liu, Y; Shen, W; Xu, Q; Yang, S; Yu, D; Zhu, W | 1 |
| Mu, X; Wang, C | 1 |
| Akter, J; Aogo, RA; Cromer, D; Davenport, MP; Elliott, T; Fogg, LG; Haque, A; Khoury, DS; Laohamonthonkul, P; Liligeto, UN; Nair, AS; Pernold, CPS; Romanczuk, AS; Soon, MSF; Thomas, BS | 1 |
| Chen, LN; Guo, Y; Jiang, XH; Li, K; Li, YJ; Yang, T; Zheng, XJ; Zheng, ZY; Zhu, XX | 1 |
| Dang, WZ; Jiang, B; Li, H; Liu, KF; Liu, LX; Nandakumar, KS; Tan, HJ; Yu, XC; Zhou, C | 1 |
| Amat, A; Cao, L; Ji, B; Li, Y; Ma, H; Mu, W; Ren, J; Wahafu, T; Wuermanbieke, S; Zhang, K | 1 |
| Cai, W; Cheng, R; Gao, G; Gu, X; Li, C; Li, L; Ma, J; Wei, L; Yang, X; Yang, Z; Yao, Y; Zhang, Y | 1 |
| Carvalho, LJ; Clemmer, L; Frangos, JA; Martins, YC; Ong, PK; Orjuela-Sánchez, P; Zanini, GM | 1 |
| Brant, F; Campos, AC; Cisalpino, D; Machado, FS; Miranda, AS; Rachid, MA; Rocha, NP; Rodrigues, DH; Souza, DG; Teixeira, AL | 1 |
| Dai, JR; Ji, Y; Li, HJ; Li, TY; Liang, YS; Qian, YL; Qu, GL; Wang, W | 1 |
| Attama, AA; Chime, SA; Chinaeke, EE; Okore, VC; Onyishi, VI | 1 |
| Amah, DJ; Bello, UM; Gbodi, AT; Kabiru, AY; Makun, HA; Ogbadoyi, EO | 1 |
| Kumar, KK; Prasad, DM; Rajyalakshmi, M; Satish, PV; Sowjanya, M; Sunita, K | 1 |
| Block, KE; Hou, L; Huang, H | 1 |
| Berman, J; Im-Erbsin, R; Li, Q; Obaldia, N; Ohrt, C; Xie, L | 1 |
| Bienvenu, AL; Bonnot, G; Bringer, C; Fourier, A; Gagnieu, MC; Lavoignat, A; Marijon, A; Picot, S | 1 |
| Brant, F; Campos, AC; Machado, FS; Miranda, AS; Teixeira, AL | 1 |
| Hanlin, S; Kexuan, T; Ming, Y; Yuliang, W; Zejian, W | 1 |
| Boivin, G; Canivet, C; Menasria, R; Piret, J; Rhéaume, C | 1 |
| Cao, J; Li, Y; Peng, Y; Wang, W; Xia, A; Xia, J; Zhang, Y | 1 |
| Baro, N; Buckee, C; Childs, LM; Daniels, R; Dow, GS; Duraisingh, MT; Gerena, L; Kyle, D; Mantel, PY; Marti, M; Mukherjee, A; Obaldía, N; Otero, W; Volkman, SK; Wirth, DF | 1 |
| Abiodun, OO; Gbimadee, N; Gbotosho, GO | 1 |
| Brennan, GP; Fairweather, I; Halferty, L; Hanna, RE; Johnston, RC; O'Neill, JF | 1 |
| Alves da Costa, T; de Carvalho, AC; de Oliveira, AL; Fraga-Silva, TF; Ishikawa, LL; Sartori, A; Thomé, R; Verinaud, L | 1 |
| Cabral, L; Cristiano, ML; Lobo, L; Nogueira, F; Sousa, Bd | 1 |
| Huang, G; Mo, B; Wang, C; Wang, Y | 1 |
| Chanarat, N; Gettayacamin, M; Komcharoen, N; Limsalakpeth, A; Rasameesoraj, M; Saunders, DL; Scott Miller, R; Siriyanonda, D; Teja-Isavadharm, P; Weina, PJ | 1 |
| Conroy, AL; Crowley, V; Hawkes, M; Hay, JG; Higgins, SJ; Kain, KC; Liles, WC; Opoka, RO; Purcell, LA; Quaggin, SE; Silver, KL; Thurston, G; Tran, V | 1 |
| Sullivan, DJ; Walker, LA | 1 |
| Huang, L; Lin, XX; Liu, Q; Song, FM; Su, YJ; Wei, CM; Xu, J; Zhao, JM; Zong, SH | 1 |
| Bienvenu, AL; Picot, S | 1 |
| El Zawawy, LA | 1 |
| Alvarez-Doval, A; Angulo-Barturen, I; Gargallo-Viola, D; Garuti, H; Gómez, V; Ibáñez, J; Jiménez-Díaz, MB; Martínez, A; Mulet, T; Shultz, LD; Viera, S | 1 |
| Hong, SJ; Hong, ST; Keiser, J; Kim, TI; Li, S; Yoo, WG | 1 |
| Gu, Z; Jiang, B; Jin, O; Sun, L; Wang, J; Xu, T; Zeng, X; Zhang, H; Zhao, S; Zhou, K | 1 |
| Li, C; Liu, HL; Sun, LK; Tang, Y; Wang, GB; Wang, XQ; Wu, PF; Xie, J; Yan, T | 1 |
| Jiao, PY; Mei, JY; Xiao, SH | 1 |
| Bueno, FG; Cabral, EC; Costa, FT; Eberlin, MN; Foglio, MA; Kayano, AC; Lopes, SC; Mello, JC; Souza-Neiras, WC; Yamauchi, LM | 1 |
| Dai, JR; Li, HJ; Li, YZ; Liang, YS; Qu, GL; Tao, YH; Wang, W; Wei, JY; Xing, YT | 1 |
| Akanbi, OM; Cyril-Olutayo, CM; Fasimoye, RY; Omonkhua, AA | 1 |
| Cheng, C; Goh, FY; Guan, SP; Ho, WE; Kong, LR; Lai, WQ; Leung, BP; Wong, WS | 1 |
| Kennedy, K; Kumar, N; Kyle, DE; LaCrue, AN; Scheel, M | 1 |
| Mo, HY; Wang, LF; Zhang, LH | 1 |
| Joshi, M; Pathak, S; Patil, S; Patravale, V; Sharma, S | 1 |
| Bian, JS; Chan, TK; Cheng, C; Guan, SP; Ho, WE; Koh, AH; Lau, HY; Ng, DS; Wong, WS | 1 |
| Cravo, P; Henriques, G; Rodrigues, L | 1 |
| Wang, NP; Wang, Q; Wu, LM; Zhang, XL; Zhao, Y | 1 |
| Dow, GS; Kyle, DE; Lee, P; Li, QG; Si, YZ; Wong, E; Xie, LH | 1 |
| Albini, A; Anfosso, L; Dell'Eva, R; Efferth, T; Forlani, A; Pfeffer, U; Vené, R | 1 |
| Keiser, J; Shu-Hua, X; Tanner, M; Utzinger, J | 1 |
| Li, Q; Lin, AJ; Skillman, DS; Smith, K; Xie, LH; Zhang, J | 1 |
| Jian, X; Keiser, J; Odermatt, P; Shu-Hua, X; Tanner, M; Tesana, S; Utzinger, J; Zhen-San, C | 1 |
| Brown, AE; Corcoran, KD; Kyle, DE; Maeno, Y; Ngampochjana, M; Ockenhouse, CF; Smith, CD; Tegoshi, T; Toyoshima, T; Webster, HK | 1 |
1 review(s) available for artesunic acid and Disease Models, Animal
| Article | Year |
|---|---|
Artemisinins-a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review.
Topics: Animals; Artemisinins; Artesunate; Disease Models, Animal; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mice | 2018 |
2 trial(s) available for artesunic acid and Disease Models, Animal
| Article | Year |
|---|---|
Efficacy of intranasal administration of artesunate in experimental cerebral malaria.
Topics: Administration, Intranasal; Animals; Antimalarials; Artemisinins; Artesunate; Blood Chemical Analysis; Brain Chemistry; Disease Models, Animal; Female; Malaria, Cerebral; Mice, Inbred CBA; Parasitemia; Placebos; Random Allocation; Single-Blind Method; Survival Analysis; Treatment Outcome | 2014 |
Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.
Topics: Adenoviridae; Angiopoietin-1; Animals; Antimalarials; Artemisinins; Artesunate; Blood-Brain Barrier; Child, Preschool; Disease Models, Animal; Disease Susceptibility; Endothelial Cells; Female; Gene Deletion; Humans; Infant; Kaplan-Meier Estimate; Kinetics; Malaria, Cerebral; Malaria, Falciparum; Male; Mice, Inbred C57BL; Phenotype; Plasmodium falciparum; Receptor, TIE-2; Recombinant Proteins; Survival Analysis; Treatment Outcome; Uganda | 2016 |
80 other study(ies) available for artesunic acid and Disease Models, Animal
| Article | Year |
|---|---|
Artesunate strongly modulates myeloid and regulatory T cells to prevent LPS-induced systemic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Artesunate; Chemokines; Cytokines; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice, Inbred BALB C; Myeloid Cells; Myeloid-Derived Suppressor Cells; Neutrophils; Phenotype; T-Lymphocytes, Regulatory | 2021 |
Acetone Ingestion Mimics a Fasting State to Improve Glucose Tolerance in a Mouse Model of Gestational Hyperglycemia.
Topics: Acetone; Animals; Antimalarials; Apelin; Artesunate; Diabetes, Gestational; Disease Models, Animal; Drug Evaluation, Preclinical; Fasting; Female; Intestines; Pancreas; Placenta; Pregnancy; Pregnancy Outcome | 2021 |
Neurogenesis and Proliferation of Neural Stem/Progenitor Cells Conferred by Artesunate via FOXO3a/p27Kip1 Axis in Mouse Stroke Model.
Topics: Animals; Artesunate; Brain Ischemia; Cell Proliferation; Diffusion Tensor Imaging; Disease Models, Animal; Infarction, Middle Cerebral Artery; Mice; Neural Stem Cells; Neurogenesis; Stroke | 2022 |
Artesunate restores mitochondrial fusion-fission dynamics and alleviates neuronal injury in Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Artesunate; Disease Models, Animal; Mice; Mice, Transgenic; Mitochondrial Dynamics; Mitochondrial Proteins; Neurons; Presenilin-1 | 2022 |
RNA-seq-based transcriptome analysis of the anti-inflammatory effect of artesunate in the early treatment of the mouse cerebral malaria model.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Gene Expression Profiling; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-6; Lead; Malaria, Cerebral; Mice; Mice, Inbred C57BL; RNA-Seq; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2022 |
Repurposing antimalarial artesunate for the prophylactic treatment of depression: Evidence from preclinical research.
Topics: Animals; Antimalarials; Antioxidants; Artesunate; Behavior, Animal; Depression; Disease Models, Animal; Inflammation; Lipopolysaccharides; Mice | 2023 |
Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate.
Topics: Alzheimer Disease; Animals; Antimalarials; Artesunate; Disease Models, Animal; Hippocampus; Mice; Receptors, Glycine; Synapses | 2023 |
The effect of artesunate to reverse CLP-induced sepsis immunosuppression mice with secondary infection is tightly related to reducing the apoptosis of T cells via decreasing the inhibiting receptors and activating MAPK/ERK pathway.
Topics: Animals; Apoptosis; Artesunate; CD8-Positive T-Lymphocytes; Coinfection; Cytokines; Disease Models, Animal; Immunosuppression Therapy; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pseudomonas Infections; Punctures; Sepsis | 2023 |
Artesunate mitigates choroidal neovascularization and scar formation.
Topics: Animals; Artesunate; Choroidal Neovascularization; Cicatrix; Disease Models, Animal; Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2023 |
Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear.
Topics: Administration, Cutaneous; Animals; Artesunate; Cicatrix, Hypertrophic; Disease Models, Animal; Dose-Response Relationship, Drug; Ear; Female; Fibroblasts; Gene Expression Regulation; Humans; Rabbits; Skin; Skin Cream; Smad3 Protein; Transforming Growth Factor beta1; Wound Healing | 2019 |
Artesunate promotes sensitivity to sorafenib in hepatocellular carcinoma.
Topics: Animals; Apoptosis; Artesunate; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Liver Neoplasms; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Proto-Oncogene Proteins c-akt; Sorafenib; TOR Serine-Threonine Kinases | 2019 |
Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.
Topics: Animals; Antimalarials; Apoptosis; Artesunate; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Repositioning; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Kruppel-Like Factor 6; Mice; Mitochondria; Rats; Retinoblastoma; Transcriptional Activation | 2019 |
Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L.
Topics: Adaptive Immunity; Animals; Apoptosis; Artemisia annua; Artesunate; Biological Products; Cells, Cultured; Colitis; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Immunologic Factors; Interleukin-12; Intestinal Mucosa; Macrophages; Mice; Mice, Inbred C57BL; THP-1 Cells; Tumor Necrosis Factor-alpha | 2020 |
Artesunate inhibits osteoclastogenesis through the miR-503/RANK axis.
Topics: Animals; Artesunate; Cell Differentiation; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; MAP Kinase Signaling System; Mice; MicroRNAs; Osteoclasts; Osteogenesis; Osteoporosis; RANK Ligand; RAW 264.7 Cells; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Tartrate-Resistant Acid Phosphatase | 2020 |
Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo.
Topics: Aminoquinolines; Animals; Antimalarials; Artesunate; Babesia bovis; Babesia microti; Babesiosis; Disease Models, Animal; Drug Combinations; In Vitro Techniques; Lumefantrine; Mefloquine; Methylene Blue; Mice; Mice, Inbred BALB C | 2020 |
Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling.
Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Artesunate; Carcinogenesis; Cell Line, Tumor; Cell Nucleus; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatocyte Nuclear Factor 1-alpha; Humans; Intestinal Mucosa; Male; Mice; Mice, Transgenic; Mutation; Promoter Regions, Genetic; ran GTP-Binding Protein; T Cell Transcription Factor 1; Transcriptional Activation; Wnt Signaling Pathway | 2021 |
Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway.
Topics: Animals; Aorta; Artesunate; Atherosclerosis; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Kruppel-Like Transcription Factors; Lipids; Lipoprotein Lipase; Male; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Plaque, Atherosclerotic; Signal Transduction; Transcription Factor 7-Like 2 Protein; Up-Regulation | 2020 |
Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance.
Topics: Animals; Artesunate; Bacteria; Bacterial Load; Cells, Cultured; Cytokines; Disease Models, Animal; Glucocorticoids; Immunoglobulin A, Secretory; Immunologic Factors; Immunosuppression Therapy; Interleukin-6; Leukocytes; Macrophages, Peritoneal; Male; Mice, Inbred BALB C; Spleen; Thymus Gland; Toll-Like Receptor 4; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha | 2021 |
Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling.
Topics: Animals; Artesunate; Autoantibodies; Autoimmunity; B-Cell Activating Factor; B-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Humans; Immunologic Factors; Intracellular Signaling Peptides and Proteins; Lymphocytes; Mice, Inbred ICR; Mice, Inbred NOD; NF-kappa B; Salivary Glands; Signal Transduction; Sjogren's Syndrome | 2021 |
Leishmania amazonensis response to artemisinin and derivatives.
Topics: Animals; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Female; Leishmania mexicana; Mice; Mice, Inbred BALB C; Parasite Load; Trypanocidal Agents | 2021 |
Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
Topics: Adoptive Transfer; Animals; Artesunate; Disease Models, Animal; Docosahexaenoic Acids; Lipopolysaccharides; Listeria monocytogenes; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Pain; Phagocytosis; Plasmodium berghei; Receptors, G-Protein-Coupled; Sepsis | 2021 |
Artesunate ameliorates cigarette smoke-induced airway remodelling via PPAR-γ/TGF-β1/Smad2/3 signalling pathway.
Topics: Airway Remodeling; Animals; Artesunate; Cell Line; Cytokines; Disease Models, Animal; Female; Humans; Inflammation Mediators; Lung; Male; Myocytes, Smooth Muscle; Oxidative Stress; PPAR gamma; Pulmonary Disease, Chronic Obstructive; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Smoke; Tobacco Products; Transforming Growth Factor beta1 | 2021 |
Artesunate Attenuated the Progression of Abdominal Aortic Aneurysm in a Mouse Model.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Artesunate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL | 2021 |
Targeting NF-kappa B Signaling by Artesunate Restores Sensitivity of Castrate-Resistant Prostate Cancer Cells to Antiandrogens.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Caspase 3; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Male; Mice; Neoplasm Metastasis; NF-kappa B; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms, Castration-Resistant; Proteolysis; Signal Transduction; Tumor Burden; Ubiquitin; Xenograft Model Antitumor Assays | 2017 |
Artesunate and erythropoietin synergistically improve the outcome of experimental cerebral malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Brain; Cytokines; Dendritic Cells; Disease Models, Animal; Drug Synergism; Erythropoietin; Female; Intercellular Adhesion Molecule-1; Malaria, Cerebral; Mice, Inbred C57BL; Plasmodium berghei; Spleen; T-Lymphocytes; Vascular Cell Adhesion Molecule-1 | 2017 |
Adaptive immunity is essential in preventing recrudescence of Plasmodium yoelii malaria parasites after artesunate treatment.
Topics: Adaptive Immunity; Animals; Antimalarials; Artemisinins; Artesunate; B-Lymphocytes; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drug Resistance; Female; Malaria; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Plasmodium yoelii; Recurrence | 2017 |
Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood-Brain Barrier; Disease Models, Animal; Drug Evaluation; Heterocyclic Compounds; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Parasitemia; Plasmodium berghei; Quinine; Quinolines; Random Allocation; Safety | 2017 |
Topics: Alcohol Dehydrogenase; Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Female; Malaria, Cerebral; Male; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Plasmodium berghei; Survival Analysis; T-Lymphocytes; Treatment Outcome | 2017 |
Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis.
Topics: Animals; Apoptosis; Artemisinins; Artesunate; Arthritis, Rheumatoid; Autophagy; Cartilage; Cell Cycle Checkpoints; Cell Proliferation; Chondrocytes; Collagen Type II; Disease Models, Animal; Down-Regulation; Inflammation; Liver; Male; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2018 |
The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction.
Topics: Animals; Antimalarials; Artesunate; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; MAP Kinase Signaling System; Myocardial Infarction; Myocardium; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; STAT3 Transcription Factor | 2018 |
Antischistosomal Properties of Hederacolchiside A1 Isolated from
Topics: Animals; Artemisinins; Artesunate; Disease Models, Animal; Female; Mice; Plant Extracts; Praziquantel; Pulsatilla; Saponins; Schistosoma japonicum; Schistosoma mansoni; Schistosomiasis; Schistosomicides | 2018 |
Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice.
Topics: Animals; Antimalarials; Artesunate; Blood; Disease Models, Animal; Fluorescence; Malaria; Mefloquine; Mice; Models, Theoretical; Organisms, Genetically Modified; Parasite Load; Parasitemia; Plasmodium berghei; Staining and Labeling | 2018 |
[Protective effects of artesunate combination on experimental cerebral malaria and nerve injury].
Topics: Animals; Antimalarials; Artesunate; Disease Models, Animal; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Plasmodium berghei | 2018 |
Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2-STAT3 signaling pathway.
Topics: Animals; Antimalarials; Artesunate; Autoantibodies; Cell Differentiation; Cytokines; Disease Models, Animal; Female; Humans; Janus Kinase 2; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphocyte Activation; Male; Mice; Mice, Inbred MRL lpr; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 2019 |
Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.
Topics: Animals; Apoptosis; Artesunate; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cells, Cultured; Chondrocytes; Cytokines; Disease Models, Animal; Disease Progression; Inflammation Mediators; Interleukin-1beta; Mice; NF-kappa B; Osteoarthritis; Signal Transduction | 2019 |
The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.
Topics: Angiogenesis Inhibitors; Animals; Annexin A5; Antimalarials; Apoptosis; Artemisinins; Artesunate; bcl-2-Associated X Protein; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Endothelial Cells; Eye Burns; Female; Flow Cytometry; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium Hydroxide | 2013 |
Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria.
Topics: Administration, Intravenous; Animals; Antihypertensive Agents; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Electrocardiography; Female; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Nimodipine; Plasmodium berghei; Salvage Therapy; Survival Analysis; Treatment Outcome | 2013 |
Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Artesunate; Cytokines; Cytological Techniques; Disease Models, Animal; Female; Frontal Lobe; Gene Expression Profiling; Hippocampus; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Plasmodium berghei; Real-Time Polymerase Chain Reaction; RNA, Messenger; Survival Analysis | 2013 |
Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum.
Topics: Administration, Oral; Animals; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Drug Resistance; Female; Mice; Mice, Inbred ICR; Praziquantel; Schistosoma japonicum; Schistosomiasis japonica; Schistosomicides | 2014 |
Formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Malaria; Mice; Microspheres; Particle Size; Plant Oils; Plasmodium berghei; Scattering, Small Angle; Soybean Oil; X-Ray Diffraction | 2015 |
Evaluation of haematological changes in Plasmodium-berghei-infected mice administered with aqueous extract of Phyllantus amarus.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocyte Count; Female; Hematocrit; Leukocyte Count; Malaria; Male; Mice; Phyllanthus; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Plasmodium berghei; Time Factors | 2013 |
Human malaria in C57BL/6J mice: an in vivo model for chemotherapy studies.
Topics: Animals; Artemisinins; Artesunate; Disease Models, Animal; Drug Resistance, Multiple; Female; Humans; Malaria; Mice; Mice, Inbred C57BL; Parasitemia; Plasmodium falciparum | 2014 |
Artesunate abolishes germinal center B cells and inhibits autoimmune arthritis.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Germinal Center; Lymphocyte Activation; Mice; Mice, Inbred NOD; Mice, Transgenic; Random Allocation; T-Lymphocytes, Helper-Inducer | 2014 |
Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria.
Topics: Administration, Intravenous; Animals; Antimalarials; Aotidae; Artemisinins; Artesunate; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Macaca mulatta; Malaria; Male; Methylene Blue; Plasmodium berghei; Plasmodium cynomolgi; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2014 |
Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria.
Topics: Animals; Antimalarials; Anxiety; Artemisinins; Artesunate; Brain-Derived Neurotrophic Factor; Cannabidiol; Cognition; Disease Models, Animal; Drug Therapy, Combination; Female; Hippocampus; Malaria, Cerebral; Memory Disorders; Mice, Inbred C57BL; Nerve Growth Factor; Neuroprotective Agents; Plasmodium berghei; Prefrontal Cortex; Survival Analysis; Treatment Outcome | 2015 |
The hypolipidemic effect of artesunate and ursolic acid in rats.
Topics: Animals; Artemisinins; Artesunate; Atorvastatin; Cholesterol; Disease Models, Animal; Heptanoic Acids; Hyperlipidemias; Hypolipidemic Agents; Pyrroles; Rats; Triglycerides; Triterpenes; Ursolic Acid | 2015 |
Valacyclovir combined with artesunate or rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Artemisinins; Artesunate; Brain; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Encephalitis, Herpes Simplex; Female; Immunologic Factors; Injections, Intraperitoneal; Mice, Inbred BALB C; Sirolimus; Survival Analysis; Treatment Outcome; Valacyclovir; Valine; Viral Load | 2015 |
Artesunate attenuates unilateral ureteral obstruction-induced renal fibrosis by regulating the expressions of bone morphogenetic protein-7 and uterine sensitization-associated gene-1 in rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Artemisinins; Artesunate; Bone Morphogenetic Protein 7; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Male; Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Ureteral Obstruction | 2016 |
Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.
Topics: Adaptation, Biological; Animals; Antimalarials; Aotidae; Artemisinins; Artesunate; Disease Models, Animal; Drug Resistance; Host-Pathogen Interactions; Malaria, Falciparum; Parasitic Sensitivity Tests; Phenotype; Plasmodium falciparum; Primates; Quantitative Trait Loci; Treatment Failure | 2016 |
Lopinavir/ritonavir enhanced the antimalarial activity of amodiaquine and artesunate in a mouse model of Plasmodium berghei.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; HIV Protease Inhibitors; Lopinavir; Malaria; Mice; Plasmodium berghei; Ritonavir | 2016 |
Disruption of spermatogenesis in the liver fluke, Fasciola hepatica by two artemisinin derivatives, artemether and artesunate.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Apoptosis; Artemether; Artemisinins; Artesunate; Cell Count; Cell Survival; Disease Models, Animal; Fasciola hepatica; Fascioliasis; Histocytochemistry; Male; Microscopy, Electron, Transmission; Mitochondria; Rats; Spermatogenesis; Spermatozoa; Time Factors | 2017 |
Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Artemisinins; Artesunate; Brefeldin A; Cell Movement; Central Nervous System; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Flow Cytometry; Gene Expression Regulation; Ionomycin; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Phorbol Esters | 2016 |
Highly active ozonides selected against drug resistant malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Female; Humans; Malaria, Falciparum; Mefloquine; Mice; Parasitemia; Plasmodium falciparum | 2016 |
Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats.
Topics: Animals; Artemisinins; Artesunate; Collagen Type IV; Disease Models, Animal; Extracellular Matrix; Gene Expression Regulation; Humans; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pulmonary Fibrosis; Rats; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2016 |
Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Macaca mulatta; Malaria; Splenectomy; Treatment Outcome; United States | 2016 |
Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model.
Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Female; Malaria; Mice; Mice, Inbred BALB C; Quinolines | 2017 |
Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo.
Topics: Animals; Artemisinins; Artesunate; Bone Resorption; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; I-kappa B Proteins; Lipopolysaccharides; Male; Mice, Inbred C57BL; Osteoclasts; Osteogenesis; Osteolysis; Phosphorylation; Proteolysis; RANK Ligand; Signal Transduction; Time Factors; Transcription Factor RelA; X-Ray Microtomography | 2018 |
Statins alone are ineffective in cerebral malaria but potentiate artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atorvastatin; Disease Models, Animal; Drug Synergism; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Malaria, Cerebral; Malaria, Falciparum; Mice; Neuroprotective Agents; Pravastatin; Pyrroles; Simvastatin | 2008 |
Effect of artesunate on Toxoplasma gondii: in vitro and in vivo studies.
Topics: Animals; Antiprotozoal Agents; Artemisinins; Artesunate; Disease Models, Animal; Humans; Mice; Microscopy, Electron, Scanning; Parasite Egg Count; Random Allocation; Toxoplasma; Toxoplasmosis; Treatment Outcome | 2008 |
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Erythrocytes; Humans; Interleukin Receptor Common gamma Subunit; Kinetics; Malaria, Falciparum; Mice; Mice, Inbred NOD; Mice, SCID; Pyridones; Pyrimethamine | 2009 |
Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits.
Topics: Administration, Oral; Animals; Anthelmintics; Artemether; Artemisinins; Artesunate; Bile Ducts; Clonorchiasis; Clonorchis sinensis; Disease Models, Animal; Praziquantel; Rabbits | 2009 |
A pilot study of the therapeutic efficacy and mechanism of artesunate in the MRL/lpr murine model of systemic lupus erythematosus.
Topics: Animals; Antibodies, Antinuclear; Artemisinins; Artesunate; B-Cell Activating Factor; Body Weight; Chemokine CCL2; Disease Models, Animal; Female; Gene Expression Regulation; Leukocytes; Lupus Erythematosus, Systemic; Mice; Pilot Projects; Proteinuria | 2009 |
Effect of artesunate on endotoxin-induced uveitis in rats.
Topics: Animals; Aqueous Humor; Artemisinins; Artesunate; Chemokine CCL2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Eye Proteins; Immunosuppressive Agents; Injections, Intravenous; Lipopolysaccharides; Male; Nitric Oxide; Rats; Rats, Long-Evans; Salmonella typhimurium; Tumor Necrosis Factor-alpha; Uveitis, Anterior | 2011 |
Effect of mefloquine administered orally at single, multiple, or combined with artemether, artesunate, or praziquantel in treatment of mice infected with Schistosoma japonicum.
Topics: Administration, Oral; Animals; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Mefloquine; Mice; Mice, Inbred Strains; Parasitic Diseases, Animal; Parasitic Sensitivity Tests; Praziquantel; Schistosoma japonicum; Schistosomiasis japonica; Schistosomicides; Treatment Outcome | 2011 |
In vitro and in vivo assessment of the anti-malarial activity of Caesalpinia pluviosa.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Brazil; Caesalpinia; Cell Line; Cell Survival; Disease Models, Animal; Drug Synergism; Humans; Malaria; Mice; Mice, Inbred C57BL; Plant Bark; Plant Extracts; Plants, Medicinal; Plasmodium chabaudi; Plasmodium falciparum; Quercetin; Rodent Diseases | 2011 |
Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Female; Mice; Rodent Diseases; Schistosoma japonicum; Schistosomiasis japonica; Treatment Outcome | 2011 |
The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood Chemical Analysis; Combretaceae; Disease Models, Animal; Lipids; Liver; Malaria; Mice; Oxidative Stress; Parasitemia; Plant Bark; Plant Extracts; Plasmodium berghei; Superoxide Dismutase; Treatment Outcome | 2012 |
Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Artesunate; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Female; Gene Expression Regulation; Humans; Hypersensitivity; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyroglyphidae; Signal Transduction; Th2 Cells | 2011 |
Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Malaria; Mice; Plasmodium | 2011 |
[Effects of artesunate on tumor necrosis factor alpha and chemotactic factors in the serum and the synoviocyte culture supernate of collagen-induced arthritis rats].
Topics: Animals; Artemisinins; Artesunate; Arthritis, Experimental; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Disease Models, Animal; Male; Rats; Rats, Wistar; Synovial Fluid; Tumor Necrosis Factor-alpha | 2012 |
Intravenous β-artemether formulation (ARM NLC) as a superior alternative to commercial artesunate formulation.
Topics: Administration, Intravenous; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Treatment Outcome | 2012 |
Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antimalarials; Artemisinins; Artesunate; Asthma; Cell Degranulation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Immunity, Cellular; Immunoblotting; Immunoglobulin E; In Vitro Techniques; Mast Cells; Mice; Random Allocation | 2013 |
MDR1-associated resistance to artesunate+mefloquine does not impair blood-stage parasite fitness in a rodent malaria model.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Drug Resistance; Host-Pathogen Interactions; Male; Mice; Multidrug Resistance-Associated Proteins; Parasitemia; Plasmodium chabaudi; Protozoan Proteins | 2013 |
[The anticancer effect of artesunate and its mechanism].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Artemisinins; Artesunate; bcl-2-Associated X Protein; Disease Models, Animal; Female; Gene Expression; Hepatocytes; Liver Neoplasms, Experimental; Male; Mice; Neoplasm Transplantation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Sesquiterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Efficacy comparison of intravenous artelinate and artesunate in Plasmodium berghei-infected Sprague-Dawley rats.
Topics: Animals; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Malaria; Male; Parasitemia; Plant Extracts; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Time Factors | 2003 |
Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate.
Topics: Angiogenesis Inhibitors; Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Collagen; Disease Models, Animal; Drug Combinations; Laminin; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Neovascularization, Physiologic; Proteoglycans; Sarcoma, Kaposi; Sesquiterpenes; Xenograft Model Antitumor Assays | 2004 |
Artesunate and artemether are effective fasciolicides in the rat model and in vitro.
Topics: Animals; Antiplatyhelmintic Agents; Artemether; Artemisinins; Artesunate; Bile Ducts; Disease Models, Animal; Fasciola hepatica; Fascioliasis; Female; Microscopy, Electron, Scanning; Rats; Rats, Wistar; Sesquiterpenes | 2006 |
New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Malaria; Maximum Tolerated Dose; Parasitemia; Plasmodium berghei; Prodrugs; Pyrroles; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Therapeutic Equivalency | 2006 |
Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models.
Topics: Animals; Artemether; Artemisinins; Artesunate; Clonorchis sinensis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Opisthorchis; Rats; Sesquiterpenes | 2006 |
A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi.
Topics: Animals; Artemisinins; Artesunate; Brain; Cell Adhesion; Cell Adhesion Molecules; Complement C3; Disease Models, Animal; E-Selectin; Erythrocytes; Fluorescent Antibody Technique; Immunoglobulin G; Intercellular Adhesion Molecule-1; Macaca mulatta; Malaria, Cerebral; Microcirculation; Microscopy, Electron; Plasmodium; Sesquiterpenes | 1993 |